Synthesis of 5,6,11-Trideoxytetrodotoxin

  • Adachi Masaatsu
    Laboratory of Organic Chemistry, Graduate School of Bioagricultural Sciences, Nagoya University
  • Sakakibara Ryo
    Laboratory of Organic Chemistry, Graduate School of Bioagricultural Sciences, Nagoya University
  • Satake Yoshiki
    Laboratory of Organic Chemistry, Graduate School of Bioagricultural Sciences, Nagoya University
  • Isobe Minoru
    Laboratory of Organic Chemistry, Graduate School of Bioagricultural Sciences, Nagoya University
  • Nishikawa Toshio
    Laboratory of Organic Chemistry, Graduate School of Bioagricultural Sciences, Nagoya University

Abstract

5,6,11-Trideoxytetrodotoxin, a naturally occurring analog of tetrodotoxin, was synthesized from a synthetic intermediate of 5-deoxytetrodotoxin by continuous radical deoxygenation of two hydroxy groups at the C-6 and C-11 positions.

Journal

  • Chemistry Letters

    Chemistry Letters 43 (11), 1719-1721, 2014

    The Chemical Society of Japan

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