Cell Host & Microbe
Volume 15, Issue 1, 15 January 2014, Pages 95-102
Journal home page for Cell Host & Microbe

Short Article
Gut Dysbiosis Promotes M2 Macrophage Polarization and Allergic Airway Inflammation via Fungi-Induced PGE2

https://doi.org/10.1016/j.chom.2013.12.010Get rights and content
Under an Elsevier user license
open archive

Highlights

  • Antibiotic treatment induced gut fungal overgrowth

  • Gut fungal overgrowth promoted allergic airway inflammation

  • Gut fungal overgrowth elevated plasma PGE2 that promoted M2 macrophage polarization

  • M2 macrophage was involved in allergic airway inflammation

Summary

Although imbalances in gut microbiota composition, or “dysbiosis,” are associated with many diseases, the effects of gut dysbiosis on host systemic physiology are less well characterized. We report that gut dysbiosis induced by antibiotic (Abx) treatment promotes allergic airway inflammation by shifting macrophage polarization in the lung toward the alternatively activated M2 phenotype. Adoptive transfer of alveolar macrophages derived from Abx-treated mice was sufficient to increase allergic airway inflammation. Abx treatment resulted in the overgrowth of a commensal fungal Candida species in the gut and increased plasma concentrations of prostaglandin E2 (PGE2), which induced M2 macrophage polarization in the lung. Suppression of PGE2 synthesis by the cyclooxygenase inhibitors aspirin and celecoxib suppressed M2 macrophage polarization and decreased allergic airway inflammatory cell infiltration in Abx-treated mice. Thus, Abx treatment can cause overgrowth of particular fungal species in the gut and promote M2 macrophage activation at distant sites to influence systemic responses including allergic inflammation.

Cited by (0)