Letter to the EditorMechanism of phosphatidylserine inhibition of IgE/FcεRI-dependent anaphylactic human basophil degranulation via CD300a
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Cited by (18)
Antibody-mediated regulation of basophils: emerging views and clinical implications
2023, Trends in ImmunologyThe secretome of irradiated peripheral blood mononuclear cells attenuates activation of mast cells and basophils
2022, eBioMedicineCitation Excerpt :An inhibitory effect of CD300a has been demonstrated previously by Sabato and colleagues who showed that apoptotic cells prevented Bet v 1-induced CD63 upregulation in basophils of individuals allergic to birch pollens.51 Mechanistically, the authors reported that binding of the apoptosis-related signal molecule phosphatidylserine (PS) to CD300a inhibited IgE/FcεRI-dependent basophil degranulation.46,51 Previously, we successfully employed PBMCsec in a mouse model for DNFB-induced contact hypersensitivity and identified the lipid fraction as the major active ingredients to mediate the pharmacological effect.26
CD300c costimulates IgE-mediated basophil activation, and its expression is increased in patients with cow's milk allergy
2019, Journal of Allergy and Clinical ImmunologyCitation Excerpt :However, less is known about the role of human CD300 molecules in controlling activation status of basophils, eosinophils, and mast cells during allergic responses. Specifically for basophils, only the ability of the CD300a inhibitory receptor to downregulate IgE-mediated activation of these cells has been described.33-35 Here, for the first time, we show that basophils express not only the CD300a inhibitory receptor but also CD300f and the CD300c activating receptor at lower levels.
Polyfunctional HIV-1 specific response by CD8+ T lymphocytes expressing high levels of CD300a
2020, Scientific ReportsThe expression and function of CD300 molecules in the main players of allergic responses: Mast cells, basophils and eosinophils
2020, International Journal of Molecular Sciences
This research was funded by the Research Foundation Flanders/Fonds Wetenschappelijk Onderzoek (FWO). V.S. is a clinical researcher of the Research Foundation Flanders/Fonds Wetenschappelijk Onderzoek (FWO: 1700614N). D.G.E. is a senior clinical researcher of the Research Foundation Flanders/Fonds Wetenschappelijk Onderzoek (FWO: 1800614N). M.B. received a grant from the European Academy of Allergology and Clinical Immunology (EAACI Fellowship Award 2012). We also acknowledge the BMBS COST Action BM1007 “Mast Cells and Basophils – Targets for Innovative Therapies,” which facilitated their collaboration on this study and provided funds for an Short-Term Scientific Mission (STSM) for S.S.
Disclosure of potential conflict of interest: V. Sabato has received research support from Fonds Wetenschappelijk Onderzoek and has received payment for lectures from Stallergenes. C. H. Bridts has patents with BD Biosciences and has received travel support from ThermoFisher Scientific. A. Shibuya has received research support from CREST/JST. D. G. Ebo has received research support from Fonds Wetenschappelijk Onderzoek, has received payment for lectures from Stallergenes and Thermofisher, and has patents with BD Bioscience. The rest of the authors declare that they have no relevant conflicts of interest.