Virtual laboratory to accelerate international collaboration on 3D morphological logic

• Project Area: Discovery of the logic that establishes the 3D structure of organisms
• Project/Area Number: 15K21726
• Research Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
• Allocation Type: Multi-year Fund
• Review Section: Biological Sciences
• Research Institution: Osaka University
• Principal Investigator: 近藤 滋 大阪大学, 生命機能研究科, 教授 (10252503)
• Co-Investigator(Kenkyū-buntansha): 武田 洋幸 東京大学, 大学院理学系研究科(理学部), 教授 (80179647) ; 上野 直人 基礎生物学研究所, 形態形成研究部門, 教授 (40221105) ; 松野 健治 大阪大学, 理学研究科, 教授 (60318227) ; 松本 健郎 名古屋大学, 工学研究科, 教授 (30209639) ; 芳賀 永 北海道大学, 先端生命科学研究院, 教授 (00292045) ; 井上 康博 京都大学, 工学研究科, 教授 (80442929) ; 秋山 正和 明治大学, 先端数理科学インスティテュート, 特任准教授 (10583908) ; 大澤 志津江 名古屋大学, 理学研究科, 教授 (80515065)
• Project Period (FY): 2015-11-06 – 2021-03-31
• Project Status: Completed (Fiscal Year 2020)
• Budget Amount: ¥81,120,000 (Direct Cost: ¥62,400,000、Indirect Cost: ¥18,720,000); Fiscal Year 2019: ¥16,380,000 (Direct Cost: ¥12,600,000、Indirect Cost: ¥3,780,000); Fiscal Year 2018: ¥16,380,000 (Direct Cost: ¥12,600,000、Indirect Cost: ¥3,780,000); Fiscal Year 2017: ¥16,380,000 (Direct Cost: ¥12,600,000、Indirect Cost: ¥3,780,000); Fiscal Year 2016: ¥16,380,000 (Direct Cost: ¥12,600,000、Indirect Cost: ¥3,780,000); Fiscal Year 2015: ¥15,600,000 (Direct Cost: ¥12,000,000、Indirect Cost: ¥3,600,000)
• Keywords: 3D形態形成 / シミュレ―ション / 折り畳み / 回転 / クチクラ / 培養細胞の回転 / 形態形成 / 昆虫 / 体節 / 外骨格 / シミュレーション / ３次元 / 数理モデル / 物理計測 / 三次元 / 発生 / 力学 / ３Ｄ形態 / メカノバイオロジー / システムバイオロジー

Outline of Annual Research Achievements

2年目より、毎年一回のシンポジウムを、海外の３Ｄ形態形成研究で著名な研究所と共同で行った。2017年（米国ＵＣアーバイン）、2018年（オーストリアCTI）、2019年（トロント大学医学部）。最終年度は2019年10月にバルセロナのEMBLで国際会議を開くことを準備していた。事前準備として、領域代表の近藤が9月にＥＭＢＬを訪問し、セミナーを行うなど、現地の研究者と交流した。しかし、直前になり、バルセロナでカタルーニャ州の独立を求めるゼネストが起き、空港が群衆に占拠された、先方より「安全を保障できないため、会議は中止にする」という連絡が入り、会議は開催されず、リモートでの意見交換にとどまった。
CTIには、2016年から4年間、ポスドク1名を派遣し、現地で開発された技術の日本への紹介と、日本側の研究の普及に役立てている。
コスタリカ大学との共同研究は、3回のサンプル採取を現地で行い、継続中である。現地研究室（Paul Hanson教授）とは、2019年に現地でジョイントセミナーを開催し、多数の参加者を集めた。共同研究論文も、2020年に出版されている。生物サンプルを海外において採取し、それを基に研究することは、現地政府の規制が強くなり、年々難しくなっている。特に熱帯生物の宝庫であるコスタリカは棋聖が厳格であるため、現地研究者の協力なしには研究が行えない。Hanson教授とのパイプは、その点で大いに貴重であり、本領域以外の研究者にも活用してもらいたいと考えている。
海外との共同研究は、領域全体（公募を含む）で述べ62件。本領域の研究者が主催した海外での学会などのワークショップとシンポは、2018年度までで156件。国際学会のおける招待講演50回。ネットニュースを含む海外での一般報道が17回、となっている。

Research Products

• [Int'l Joint Research] National center for Biological Sciences(インド)
• [Int'l Joint Research] The WCMB(英国)
• [Int'l Joint Research] Mechanobiology Institute(シンガポール)
• [Int'l Joint Research] ベイラー医科大学（Baylor College of Medicine）(米国)
• [Int'l Joint Research] The University of Manchester(英国)
• [Int'l Joint Research]
• [Int'l Joint Research] University of Costa Rica(コスタリカ)
• [Int'l Joint Research] Harvard Medical School(米国)
• [Int'l Joint Research] Purdue University/Louisiana State University(米国)
• [Int'l Joint Research] Heiderberg University(ドイツ)
• [Int'l Joint Research] Harvard Medeical School(アメリカ)
• [Int'l Joint Research] Heidelberg University(ドイツ)
• [Int'l Joint Research] National Centre for Biological Science(インド)
• [Int'l Joint Research] University of Costa Rica(コスタリカ)
• [Int'l Joint Research] Mechanobiology Institute(シンガポール)
• [Int'l Joint Research] University of Costa Rica(コスタリカ)
• [Int'l Joint Research] Harvard University(アメリカ)
• [Journal Article] Mechanical Stress Regulates Epithelial Tissue Integrity and Stiffness through the FGFR/Erk2 Signaling Pathway during Embryogenesis (2020)
  • Author(s): Kinoshita Noriyuki、Hashimoto Yutaka、Yasue Naoko、Suzuki Makoto、Cristea Ileana M.、Ueno Naoto
  • Journal Title: Cell Rep. Volume: 30 Pages: 3875-3888
  • DOI: 10.1016/j.celrep.2020.02.074
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Structure and development of the complex helmet of treehoppers (Insecta: Hemiptera: Membracidae) (2020)
  • Author(s): Adachi Haruhiko、Matsuda Keisuke、Nishida Kenji、Hanson Paul、Kondo Shigeru、Gotoh Hiroki
  • Journal Title: Zoological Letters Volume: 6
  • DOI: 10.1186/s40851-020-00155-7
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Intrauterine pressures adjusted by Reichert’s membrane are crucial for early mouse morphogenesis. (2020)
  • Author(s): Yoko Ueda, Chiharu Kimura-Yoshida, Kyoko Mochida, Mami Tsume, Yoshitaka Kameo, Taiji Adachi, Olivier Lefebvre, Ryuji Hiramatsu and Isao Matsuo
  • Journal Title: Cell Reports Volume: 31 Pages: 107637-107637
  • DOI: 10.1016/j.celrep.2020.107637
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] A chordate species lacking Nodal utilizes calcium oscillation and Bmp for left-right patterning. (2020)
  • Author(s): Onuma, T.A., Hayashi, M., Gyoja, F., Kishi, K., Wang, K., Nishida, H.
  • Journal Title: Proc. Natl. Acad. Sci. USA Volume: 117 Pages: 4188-4198
  • DOI: 10.1073/pnas.1916858117
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Combined deletions of IHH and NHEJ1 cause chondrodystrophy and embryonic lethality in the Creeper chicken (2020)
  • Author(s): Kinoshita Keiji、Suzuki Takayuki、Koike Manabu、Nishida Chizuko、Koike Aki、Nunome Mitsuo、Uemura Takeo、Ichiyanagi Kenji、Matsuda Yoichi
  • Journal Title: Communications Biology Volume: 3 Pages: 144-144
  • DOI: 10.1038/s42003-020-0870-z
  • Peer Reviewed / Open Access
• [Journal Article] Regrowth of zebrafish caudal fin regeneration is determined by the amputated length (2020)
  • Author(s): Uemoto Toshiaki、Abe Gembu、Tamura Koji
  • Journal Title: Scientific Reports Volume: 10
  • DOI: 10.1038/s41598-020-57533-6
  • Peer Reviewed / Open Access
• [Journal Article] Maternal almondex, a neurogenic gene, is required for proper subcellular Notch distribution in early Drosophila embryogenesis. (2020)
  • Author(s): Das, P., Salazar, J. L., Li-Kroeger, D., Yamamoto, S., Nakamura, M., Sasamura, T., Inaki, M., Masuda, W., Kitagawa, M., Yamakawa, M., and Matsuno, K.
  • Journal Title: Dev. Grow. & Diff. Volume: 62 Pages: 80-93
  • DOI: 10.1111/dgd.12639
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Mesenchymal actomyosin contractility is required for androgen-driven urethral masculinization in mice. (2019)
  • Author(s): Acebedo AR, Suzuki K, Hino S, Alcantara MC, Sato Y, Haga H, Matsumoto KI, Nakao M, Shimamura K, Takeo T, Nakagata N, Miyagawa S, Nishinakamura R, Adelstein RS, Yamada G.
  • Journal Title: Commun Biol. Volume: eCollection Pages: 95-95
  • DOI: 10.1038/s42003-019-0336-3
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Differential contributions of nonmuscle myosin IIA and IIB to cytokinesis in human immortalized fibroblasts (2019)
  • Author(s): Yamamoto K., Otomo K., Nemoto T., Ishihara S., Haga H., Nagasaki A., Murakami Y., Takahashi M.
  • Journal Title: Experimental Cell Research Volume: 376 Pages: 67-76
  • DOI: 10.1016/j.yexcr.2019.01.020
  • Peer Reviewed
• [Journal Article] Modulation and characterization of the double network hydrogel surface-bulk transition. (2019)
  • Author(s): Frauenlob M, King DR, Guo H, Ishihara S, Tsuda M, Kurokawa T, Haga H, Tanaka S, Gong JP.
  • Journal Title: Macromolecules Volume: 52 Pages: 6704-6713
  • DOI: 10.1021/acs.macromol.9b01399
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Analysis of Heterogeneous Deformation in the Wall of Rabbit Thoracic Aorta at Microscopic Level (2019)
  • Author(s): Fan Y, Wang JF, Maeda E, Murase K, Matsumoto T
  • Journal Title: ABE Volume: 8 Issue: 0 Pages: 17-13
  • DOI: 10.14326/abe.8.7
  • NAID: 130007552693
  • ISSN: 2187-5219
  • Peer Reviewed / Open Access
• [Journal Article] A novel FRET analysis method for tension dynamics in a single actin stress fiber: Application to MC3T3-E1 cells during movement on a substrate (2019)
  • Author(s): Wang Junfeng、Sugita Shukei、Michiue Tatsuo、Tsuboi Takashi、Kitaguchi Tetsuya、Matsumoto Takeo
  • Journal Title: J Biorheol Volume: 33 Issue: 1 Pages: 21-26
  • DOI: 10.17106/jbr.33.21
  • NAID: 130007674886
  • ISSN: 1867-0466, 1867-0474
  • Peer Reviewed / Open Access
• [Journal Article] Shape-dependent regulation of differentiation lineages of bone marrow-derived cells under cyclic stretch (2019)
  • Author(s): Maeda Eijiro、Atsumi Yoshinori、Ishiguro Mai、Nagayama Kazuaki、Matsumoto Takeo
  • Journal Title: Journal of Biomechanics Volume: 96 Pages: 109371-109371
  • DOI: 10.1016/j.jbiomech.2019.109371
  • Peer Reviewed
• [Journal Article] Cells with broken left-right symmetry : roles of intrinsic cell chirality in left-right asymmetric epithelial morphogenesis. (2019)
  • Author(s): Utsunomiya, S., Sakamura, S., Sasamura, T., Ishibashi, T., Maeda, C., Inaki, M., and Matsuno K.
  • Journal Title: Symmetry Volume: 11 (4) Pages: 505-505
  • DOI: 10.3390/sym11040505
  • Peer Reviewed / Open Access
• [Journal Article] E and ID proteins regulate cell chirality and left-right asymmetric development in Drosophila. (2019)
  • Author(s): Ishibashi, T., Hatori, R., Maeda, R., Nakamura, M., Matsuyama, Y., and Matsuno, K.
  • Journal Title: Genes to Cells Volume: 24 (3) Pages: 214-230
  • DOI: 10.1111/gtc.12669
  • Peer Reviewed
• [Journal Article] Proper direction of male genitalia is prerequisite for copulation in Drosophila, implying cooperative evolution between genitalia rotation and mating behavior. (2019)
  • Author(s): Inatomi, M., Shin, D., Lai, Y. -T., and Matsuno, K.
  • Journal Title: Sci. Rep. Volume: 9 (1) Pages: 210-210
  • DOI: 10.1038/s41598-018-36301-7
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Horizontal Boundary Cells, a Special Group of Somitic Cells, Play Crucial Roles in the Formation of Dorsoventral Compartments in Teleost Somite (2019)
  • Author(s): Kota Abe,Atsuko Shimada,Sayaka Tayama,Hotaka Nishikawa,Takuya Kaneko, Sachiko Tsuda,Akari Karaiwa,Takaaki Matsui,Tohru Ishitani,Hiroyuki Takeda
  • Journal Title: Cell Reports Volume: 27 Pages: 928-939
  • DOI: 10.1016/j.celrep.2019.03.068
  • Peer Reviewed / Open Access
• [Journal Article] PCP-dependent transcellular regulation of actomyosin oscillation facilitates convergent extension of vertebrate tissue (2019)
  • Author(s): Shindo Asako、Inoue Yasuhiro、Kinoshita Makoto、Wallingford John B.
  • Journal Title: Developmental Biology Volume: 446 Pages: 159-167
  • DOI: 10.1016/j.ydbio.2018.12.017
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Epithelial tissue folding pattern in confined geometry (2019)
  • Author(s): Inoue Yasuhiro、Tateo Itsuki、Adachi Taiji
  • Journal Title: Biomechanics and modeling in mechanobiology Volume: 19 Pages: 815-822
  • DOI: 10.1007/s10237-019-01249-8
  • Peer Reviewed / Open Access
• [Journal Article] JNK-mediated Slit-Robo signaling facilitates epithelial wound repair by extruding dying cells. (2019)
  • Author(s): Iida C, Ohsawa S, Taniguchi K, Yamamoto M, Morata G, Igaki T
  • Journal Title: Scientific Reports Volume: 9 Pages: 19549-19549
  • DOI: 10.1038/s41598-019-56137-z
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Elimination of oncogenic cells that regulate epithelial homeostasis in Drosophila (2019)
  • Author(s): Ohsawa S
  • Journal Title: Development, Growth & Differentiation Volume: 61 Pages: 337-342
  • DOI: 10.1111/dgd.12604
  • NAID: 120006712295
  • Peer Reviewed
• [Journal Article] Drosophila flies high over the Asia-Pacific: report on the Fourth Asia-Pacific Drosophila Research Conference. (2018)
  • Author(s): Lai, Y.-T., Maeda, C., and Matsuno, K.
  • Journal Title: Genes to Cells Volume: 23 (7) Pages: 512-516
  • DOI: 10.1111/gtc.12601
  • Peer Reviewed
• [Journal Article] Local distribution of collagen fibers determines crack initiation site and its propagation direction during aortic rupture (2018)
  • Author(s): Sugita Shukei、Matsumoto Takeo
  • Journal Title: Biomechanics and Modeling in Mechanobiology Volume: 17 Pages: 577-587
  • DOI: 10.1007/s10237-017-0979-2
  • Peer Reviewed
• [Journal Article] Ex-vivo observation of calcification process in chick tibia slice: Augmented calcification along collagen fiber orientation in specimens subjected to static stretch (2018)
  • Author(s): Maeda E, Ichikawa K, Murase K, Nagayama K, Matsumoto T
  • Journal Title: Journal of Biomechanics Volume: 78 Pages: 94-101
  • DOI: 10.1016/j.jbiomech.2018.07.024
  • Peer Reviewed
• [Journal Article] Direct application of mechanical stimulation to cell adhesion sites using a novel magnetic-driven micropillar substrate (2018)
  • Author(s): Nagayama K, Inoue T, Hamada Y, Sugita S, Matsumoto T
  • Journal Title: Biomedical Microdevices Volume: 20 Pages: 85-85
  • DOI: 10.1007/s10544-018-0328-y
  • Peer Reviewed
• [Journal Article] Anisotropic Multi-channel Collagen Gel (MCCG) Guides the Growth Direction of the Neurite-like Processes of PC12 Cells (2018)
  • Author(s): Koh Isabel、Furusawa Kazuya、Haga Hisashi
  • Journal Title: Scientific Reports Volume: 8
  • DOI: 10.1038/s41598-018-32156-0
  • Peer Reviewed / Open Access
• [Journal Article] Long-term Culture of Human iPS Cell-derived Telencephalic Neuron Aggregates on Collagen Gel (2018)
  • Author(s): Oyama Hiroshi、Takahashi Koji、Tanaka Yoshikazu、Takemoto Hiroshi、Haga Hisashi
  • Journal Title: Cell Struct. Funct. Volume: 43 Issue: 1 Pages: 85-94
  • DOI: 10.1247/csf.18002
  • NAID: 130006742880
  • ISSN: 0386-7196, 1347-3700
  • Peer Reviewed / Open Access
• [Journal Article] Collective Movement and 3D Morphogenesis of Epithelial Cells Induced by Softness of the Extracellular Matrix (2018)
  • Author(s): 芳賀 永
  • Journal Title: Biophysics Volume: 58 Issue: 4 Pages: 196-199
  • DOI: 10.2142/biophys.58.196
  • NAID: 130007420830
  • ISSN: 0582-4052, 1347-4219
  • Peer Reviewed / Open Access
• [Journal Article] Competition for Space Is Controlled by Apoptosis-Induced Change of Local Epithelial Topology (2018)
  • Author(s): Tsuboi Alice、Ohsawa Shizue、Umetsu Daiki、Sando Yukari、Kuranaga Erina、Igaki Tatsushi、Fujimoto Koichi
  • Journal Title: Current Biology Volume: 28 Pages: 2115-2115
  • DOI: 10.1016/j.cub.2018.05.029
  • NAID: 120006491713
  • Peer Reviewed / Open Access
• [Journal Article] Serpin Facilitates Tumor-Suppressive Cell Competition by Blocking Toll-Mediated Yki Activation in Drosophila (2018)
  • Author(s): Katsukawa M, Ohsawa S, Zhang L, Yan Y, Igaki T
  • Journal Title: Current Biology Volume: 28 Pages: 1756-1767
  • DOI: 10.1016/j.cub.2018.04.022
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] JNK and Yorkie drive tumor progression by generating polyploid giant cells in Drosophila (2018)
  • Author(s): Cong Bojie、Ohsawa Shizue、Igaki Tatsushi
  • Journal Title: Oncogene Volume: 0 Pages: 0-0
  • DOI: 10.1038/s41388-018-0201-8
  • Peer Reviewed
• [Journal Article] Intracellular calcium signal at the leading edge regulates mesodermal sheet migration during Xenopus gastrulation. (2018)
  • Author(s): Hayashi, K., Yamamoto, T. S, and Ueno, N.
  • Journal Title: Scientific Reports Volume: 8 Pages: 2433-2433
  • DOI: 10.1038/s41598-018-20747-w
  • Peer Reviewed / Open Access
• [Journal Article] Complex furrows in a 2D epithelial sheet code the 3D structure of a beetle horn (2017)
  • Author(s): Matsuda Keisuke、Gotoh Hiroki、Tajika Yuki、Sushida Takamichi、Aonuma Hitoshi、Niimi Teruyuki、Akiyama Masakazu、Inoue Yasuhiro、Kondo Shigeru
  • Journal Title: Sci. Rep. Volume: 7 Pages: 13939-13939
  • DOI: 10.1038/s41598-017-14170-w
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Distinct intracellular Ca2+ dynamics regulate apical constriction and differentially contribute to neural tube closure. (2017)
  • Author(s): Suzuki, M., Sato, M., Koyama, H., Hara, Y., Hayashi, K., Yasue, N., Imamura H., Fujimori, T., Nagai, T. Camphbell, R. E. and Ueno, N.
  • Journal Title: Development Volume: 144 Pages: 1307-1316
  • DOI: 10.1242/dev.141952
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Genes coding for cyclin-dependent kinase inhibitors are fragile in Xenopus. (2017)
  • Author(s): Tanaka, T., Ochi, H., Takahashi, S., Ueno, N., and Taira, M.
  • Journal Title: Dev. Biol. Volume: 印刷中 Issue: 2 Pages: 30055-0
  • DOI: 10.1016/j.ydbio.2016.06.019
  • NAID: 120006605591
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Measurement of surface topography and stiffness distribution on cross-section of Xenopus laevis tailbud for estimation of mechanical environment in embryo (2017)
  • Author(s): Murakami Fumiaki、Ando Yoriko、Miyagi Asuka、Sugita Shukei、Ueno Naoto、Matsumoto Takeo
  • Journal Title: Development, Growth & Differentiation Volume: 59 Pages: 434-443
  • DOI: 10.1111/dgd.12372
  • NAID: 120006331850
  • Peer Reviewed
• [Journal Article] A novel patterned magnetic micropillar array substrate for analysis of cellular mechanical responses (2017)
  • Author(s): Nagayama Kazuaki、Inoue Takuya、Hamada Yasuhiro、Matsumoto Takeo
  • Journal Title: J Biomechanics Volume: 65 Pages: 194-202
  • DOI: 10.1016/j.jbiomech.2017.10.017
  • Peer Reviewed
• [Journal Article] Mathematical Model of Collective Cell Migrations Based on Cell Polarity (2017)
  • Author(s): M. Akiyama, T. Sushida, S. Ishida, H. Haga
  • Journal Title: Development, Growth & Differentiation Volume: 59 Pages: 471-490
  • DOI: 10.1111/dgd.12381
  • Peer Reviewed / Open Access
• [Journal Article] Left-right asymmetric morphogenesis in Drosophila and other invertebrates: the discovery of intrinsic cell chirality and its functions (2017)
  • Author(s): Inaki, M., Yang L. J., and Matsuno K.
  • Journal Title: Reviews in Cell Biology and Molecular Medicine Volume: -
  • Peer Reviewed / Open Access
• [Journal Article] The ligand Sas and its receptor PTP10D drive tumour-suppressive cell competition. (2017)
  • Author(s): Masatoshi Yamamoto (#), Shizue Ohsawa (#), Kei Kunimasa, Tatsushi Igaki (#equal contribution)
  • Journal Title: Nature Volume: 542 Pages: 246-250
  • DOI: 10.1038/nature21033
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] An updated kernel-based Turing model for studying the mechanisms of biological pattern formation (2016)
  • Author(s): Shigeru Kondo
  • Journal Title: Journal of Theoretical Biology Volume: 10；414 Pages: 120-127
  • DOI: 10.1016/j.jtbi.2016.11.003
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Tracking dynamics of histone H3 lysine 9 acetylation in Xenopus laevis tail regeneration (2016)
  • Author(s): Suzuki M, Takagi C, Miura S, Sakane Y, Sakuma T, Sakamoto N, Endo T, Kamei Y, Kimura H, Yamamoto T, Ueno N, Suzuki K
  • Journal Title: Genes Cells Volume: Vol.21 (4) Pages: 358-369
  • DOI: 10.1111/gtc.12349
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Physical association between a novel plasma-membrane structure and centrosome orients cell division. (2016)
  • Author(s): Negishi, T., Miyazaki, N., Murata, K., Yasuo, H. and Ueno, N.
  • Journal Title: Elife Volume: e16550
  • DOI: 10.7554/elife.16550
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Cell chirality: its origin and roles in left-right asymmetric development. (2016)
  • Author(s): Inaki, M., Yang L. J., and Matsuno K.
  • Journal Title: Philosophical Transaction of The Royal Society B Volume: 371 Pages: 20150403-12
  • DOI: 10.1098/rstb.2015.0403
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Dual roles of O-glucose glycans redundant with monosaccharide O-fucose on Notch in Notch Trafficking. (2016)
  • Author(s): Matsumoto, K., Ayukawa, T., Ishio, A., Sasamura, T., Yamakawa, T. and Matsuno, K.
  • Journal Title: J Biol Chem. Volume: 291 Pages: 13743-13752
  • DOI: 10.1074/jbc.m115.710483
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Effect of loading rate on viscoelastic properties and local mechanical heterogeneity of freshly isolated muscle fiber bundles subjected to uniaxial stretching (2016)
  • Author(s): Tamura A, Hayashi S, Matsumoto T
  • Journal Title: Journal of Mechanics in Medicine and Biology Volume: 16 Pages: 1650086-1650086
  • DOI: 10.1142/s021951941650086x
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Dynamics of actin filaments of MC3T3-E1 cells during adhesion process to substrate (2016)
  • Author(s): J Wang, S Sugita, K Nagayama, T Matsumoto
  • Journal Title: JBSE Volume: 3 Issue: 2 Pages: 15-00637
  • DOI: 10.1299/jbse.15-00637
  • NAID: 130005158997
  • ISSN: 1880-9863
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Differences in the Mechanical Properties of the Developing Cerebral Cortical Proliferative Zone between Mice and Ferrets at both the Tissue and Single-Cell Levels. (2016)
  • Author(s): Nagasaka, A., Shinoda, T., Kawaue, T., Suzuki, M., Nagayama, K., Matsumoto, T., Ueno, N., Kawaguchi, A. and Miyata, T.
  • Journal Title: Front. Cell Dev. Biol Volume: 25 Pages: 139-139
  • DOI: 10.3389/fcell.2016.00139
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Observations of intracellular tension dynamics of MC3T3-E1 cells during substrate adhesion using a FRET-based actinin tension sensor (2016)
  • Author(s): Wang J, Ito M, Zhong W, Sugita S, Michiue T, Tsuboi T, Kitaguchi T, Matsumoto T
  • Journal Title: JBSE Volume: 11 Issue: 4 Pages: 16-00504
  • DOI: 10.1299/jbse.16-00504
  • NAID: 130005251141
  • ISSN: 1880-9863
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Data set for comparison of cellular dynamics between human AAVS1 locus-modified and wild-type cells (2016)
  • Author(s): Takeomi Mizutani, Hisashi Haga, Kazushige Kawabata
  • Journal Title: Data in Brief Volume: 6 Pages: 793-798
  • DOI: 10.1016/j.dib.2015.12.053
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Conformational Plasticity of JRAB/MICAL-L2 Provides 'Law and Order' (2016)
  • Author(s): A. Sakane, S. Yoshizawa, M. Nishimura, Y. Tsuchiya, N. Matsushita, K. Miyake, K. Horikawa, I. Imoto, C. Mizuguchi, H. Saito, T. Ueno, S. Matsushita, H. Haga, S. Deguchi, K. Mizuguchi, H.
  • Journal Title: Mol. Biol. Cell Volume: 27 Pages: 3095-3108
  • DOI: 10.1091/mbc.e16-05-0332
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Predator-prey interactions at the interface between two groups of cells in monolayer tissue. (2016)
  • Author(s): Seiya Nishikawa,Atsuko Takamatsu, Shizue Ohsawa, Tatsushi Igaki
  • Journal Title: Journal of Theoretical Biology Volume: 404 Pages: 40-50
  • DOI: 10.1016/j.jtbi.2016.05.031
  • Peer Reviewed / Acknowledgement Compliant
• [Presentation] Turing's Reaction-Diffusion System 2 (2021)
  • Author(s): 近藤 滋
  • Organizer: THIRSTING FOR THEORETICAL BIOLOGY (ONLINE)
  • Int'l Joint Research / Invited
• [Presentation] Cell Chrality is the like between molecular and body chiralty (2020)
  • Author(s): Kenji matsuno
  • Organizer: 5th Asia pacific Drosophila research conference
  • Int'l Joint Research / Invited
• [Presentation] How is the shape of the beetle horn determined? (2019)
  • Author(s): 近藤 滋
  • Organizer: 第52回日本発生生物学会大会
• [Presentation] 貝の形態は、貝の意志が決めるというお話 (2019)
  • Author(s): 近藤 滋
  • Organizer: 第42回日本分子生物学会年会
• [Presentation] ICMMA 2019 international Conference on "Spatio-temporal patterns on various levels of the hierarchy of life" 「生命の諸階層に現れる時空間パターン」 (2019)
  • Author(s): 近藤 滋
  • Organizer: ICMMA 2019
• [Presentation] 2D Pattern by Turing Mechanism and 3D Shapes by Reversed-Origami-Method (2019)
  • Author(s): 近藤 滋
  • Organizer: 15th Biomat2019 Workshop
  • Int'l Joint Research
• [Presentation] Shape representation of cells and phase field method (2019)
  • Author(s): M. Akiyama，T. Sushida, Y.Tong, H. Kametani, A. Shimada, H. Takeda
  • Organizer: ICIAM2019 (The 9th International Congress on Industrial and Applied Mathematics)
  • Int'l Joint Research / Invited
• [Presentation] Clearing of Xenopus laevis Tailbud Embryos and Quantification of their 3D-tissue Structure toward Finite Element Analysis (2019)
  • Author(s): Ando Y, Hayashi K, Maeda E, Tsunoda R, Tanaka H, Murase K, Ueno N, Matsumoto T
  • Organizer: The 10th Asian-Pacific Conference on Biomechanics
  • Int'l Joint Research
• [Presentation] 押込試験によるアフリカツメガエル尾芽胚切断面かたさの多点計測装置の開発 (2019)
  • Author(s): 角田涼，安藤頼子，前田英次郎，上野直人，松本健郎
  • Organizer: 日本機械学会第32回バイオエンジニアリング講演会
• [Presentation] Mechanical stress regulates epithelial tissue integrity during Xenopus embryogenesis (2019)
  • Author(s): Naoto Ueno
  • Organizer: EMBO/EMBL Symposium:Mechanical Forces in Biology
  • Int'l Joint Research / Invited
• [Presentation] Three-demensional simulation of epithelial tube revealed distinctive chiral cellular behaviors that may accunt for the directinal tissue rotation (2019)
  • Author(s): Mikiko Inaki, Taishi Takigawa, Akino Okubi, Takamich Sushida, Masakazu Akiyama, Yasuhiro Inoue, Kenji Matsuno
  • Organizer: 第４２階日本分子生物学会年会
• [Presentation] A novel 3D morphologic change, cell twisting, may drive left-right directional tissue rotation (2019)
  • Author(s): Mikiko Inaki, Taishi Takigawa, Akino Okubi, Takamich Sushida, Masakazu Akiyama, Yasuhiro Inoue, Kenji Matsuno
  • Organizer: 52nd annual meeting of the Japanese societey of developmental biology
• [Presentation] Coordinated growth of midline tissues in the zebrafish axis elongation (2019)
  • Author(s): Kawanishi T
  • Organizer: 52nd Annual Meeting of the Japanese Society of Developmental Biology
  • Int'l Joint Research
• [Presentation] 発生過程の組織変形における細胞集団運動の数理モデル (2019)
  • Author(s): 齋梧 等, 井上 康博, 安達 泰治
  • Organizer: 日本機械学会第31回バイオエンジニアリング講演会
• [Presentation] Mathematical modeling of epithelial folding with cell proliferation depending on the curvature of the tissue (2019)
  • Author(s): Kentaro Morikawa, Yasuhiro Inoue
  • Organizer: 5th Computational Chemistry Symposium
  • Int'l Joint Research
• [Presentation] 組織スケールのミオシン収縮ケーブルによる上皮陥入シミュレーション (2019)
  • Author(s): 渡辺章太郎, 井上康博
  • Organizer: 日本機械学会第32回バイオエンジニアリング講演会
• [Presentation] 浸透圧勾配が引き起こす上皮細胞シートのドーム形成 (2019)
  • Author(s): 石原（石田）すみれ、秋山正和、須志田隆道、古澤和也、名黒功、立野浩輝、石原誠一郎、芳賀永
  • Organizer: 日本生物物理学会北海道支部会例会
• [Presentation] Modelling the force-dependent morphogenesis of fish vertebra with topology optimization (2018)
  • Author(s): Misaki Sakashita
  • Organizer: 2018 Annual Meeting of the Society for Mathematical Biology & the Japanese Society for Mathematical Biology
  • Int'l Joint Research
• [Presentation] 2D pattern formation by Turing mechanism and 3D shape formation by folding of cell sheet (2018)
  • Author(s): Shigeru Kondo
  • Organizer: Differential Equations arising from Organising Principles in Biology
  • Int'l Joint Research / Invited
• [Presentation] Turing mechanism for 2D pattern formation, and a proposal of another principle for 3D shape formation (2018)
  • Author(s): Shigeru Kondo
  • Organizer: Mathematical Biology
  • Int'l Joint Research / Invited
• [Presentation] 2D pattern formation by Turing mechanism and 3D shape formation by folding of cell sheet (2018)
  • Author(s): Shigeru Kondo
  • Organizer: Mittwochskolloquium (MoKo/MiKo)
  • Int'l Joint Research / Invited
• [Presentation] Pattern formation in a growing tissue (2018)
  • Author(s): Shigeru Kondo
  • Organizer: 119th International Titisee Conference on “Tissue formation and regeneration: from molecules to models”
  • Int'l Joint Research / Invited
• [Presentation] Macroscopic and microscopic heterogeneities in the aortic wall: Close correlation between biomechanical environment and protein expression (2018)
  • Author(s): Matsumoto T
  • Organizer: 21st International Conference on Mechanics in Medicine and Biology
  • Int'l Joint Research / Invited
• [Presentation] アフリカツメガエル新鮮原腸胚内部の構造観察と力学環境の推定 (2018)
  • Author(s): 丹下祥之，安東頼子，前田英次郎，村瀬晃平，上野直人，松本健郎
  • Organizer: 第41回日本バイオレオロジー学会年会
• [Presentation] 粒子散布法によるアフリカツメガエル尾芽胚のかたさ計測 (2018)
  • Author(s): 角田 涼，安東頼子，前田英次郎，村瀬晃平，上野直人，松本健郎
  • Organizer: 第41回日本バイオレオロジー学会年会
• [Presentation] 刺入法によるアフリカツメガエル新鮮胚内部の力学環境の推定 (2018)
  • Author(s): 丹下祥之，安東頼子，前田英次郎，村瀬晃平，上野直人，松本健郎
  • Organizer: 日本機械学会第31回バイオエンジニアリング講演会
• [Presentation] 多細胞系のメカノバイオロジー (2018)
  • Author(s): 芳賀 永
  • Organizer: CSJ化学フェスタ
  • Invited
• [Presentation] A Mathematical Model of Planar Cell Polarity (2018)
  • Author(s): M. Akiyama, T. Ayukawa, M. Yamazaki,
  • Organizer: SMB2018 (2018 Annual Meeting of the Society for Mathematical Biology & the Japanese Society for Mathematical Biology
  • Int'l Joint Research / Invited
• [Presentation] A mathematical model of collective cell migrations based on cell polarity (2018)
  • Author(s): Masakazu Akiyama,Takamaichi （Hokkaido University）,Hitomi Mori（Hokkaido University）,Sumire （Hokkaido University）,Hisashi Haga（Hokkaido University）
  • Organizer: 11th European Conference on Mathematical and Theoretical Biology
  • Int'l Joint Research
• [Presentation] The role of transcription factors zic1 and zic4 in dorsal somite patterning (2018)
  • Author(s): Hiroyuki Takeda
  • Organizer: 4th strategic Meeting for medaka Reserch & 3rd Regional Fish Meeting
  • Int'l Joint Research
• [Presentation] アフリカツメガエル胚内部の３次元応力分布の推定 (2017)
  • Author(s): 松本 健郎
  • Organizer: 日本機械学会第29回バイオエンジニアリング講演会
  • Place of Presentation: ウインクあいち（愛知県名古屋市）
  • Year and Date: 2017-01-19
• [Presentation] How to ｐresent an unbelievable experimental result (2017)
  • Author(s): Shigeru Kondo
  • Organizer: Gordon Research Conference-Visualization in Science & Education
  • Int'l Joint Research / Invited
• [Presentation] A Novel Membrane Invagination Controls Oriented Cell Division in Ascidian Embryo (2017)
  • Author(s): Naoto Ueno
  • Organizer: 18th International Congress of Developmental Biology
  • Int'l Joint Research / Invited
• [Presentation] Estimation of flow-induced deformation of glycocalyx layer on vascular endothelial cells: Comparison of three methods (2017)
  • Author(s): Matsumoto T, Takahashi Y, Owaki Y, Nagayama K
  • Organizer: 5th Switzerland-Japan Workshop on Biomechanics
  • Int'l Joint Research / Invited
• [Presentation] Estimation of shear deformation of glycocalyx layer on vascular endothelial cells in response to fluid flow (2017)
  • Author(s): Matsumoto T, Takahashi Y, Owaki Y, Nagayama K
  • Organizer: The Third International Symposium on Mechanobiology
  • Int'l Joint Research / Invited
• [Presentation] シマウマの模様をヒョウ柄に変える方法 (2017)
  • Author(s): 近藤 滋
  • Organizer: 第29回バイオエンジニアリング講演会
  • Place of Presentation: ウインクあいち（愛知県名古屋市）
  • Invited
• [Presentation] A unique membrane structure that determines the orientation of cell division (2017)
  • Author(s): Naoto Unoe
  • Organizer: Joint Meeting of the German and Japanese Societies of Developomental Biologists
  • Place of Presentation: University of Kiel Zoological Institute Kiel, Germany
  • Int'l Joint Research / Invited
• [Presentation] 動物発生のバイオメカニクス (2017)
  • Author(s): 上野直人、鈴木誠、根岸剛文
  • Organizer: 日本機械学会 第29回バイオエンジニアリング講演会
  • Place of Presentation: ウインクあいち（愛知県名古屋市）
• [Presentation] Estimation of endothelial glycocalyx layer deformation in response to fluid shear stress (2016)
  • Author(s): Matsumoto T, Takahashi Y, Owaki Y, Nagayama K
  • Organizer: The 16th International Conference on Biomedical Engineering
  • Place of Presentation: Singapore, Singapore
  • Year and Date: 2016-12-07
  • Int'l Joint Research
• [Presentation] Tetragonal versus hexagonal tiling of the Drosophila eye (2016)
  • Author(s): 林貴史、秋山正和、佐藤純
  • Organizer: 12th Japanese Drosophila Research Conference
  • Place of Presentation: 立教大学（東京都豊島区）
  • Year and Date: 2016-09-09
• [Presentation] A Mathematical Model of Planar Cell Polarity (2016)
  • Author(s): M. Akiyama、T. Ayukawa、M. Yamazaki
  • Organizer: International Conference:Patterns and Waves 2016
  • Place of Presentation: 北海道大学（北海道札幌市）
  • Year and Date: 2016-08-01
  • Int'l Joint Research
• [Presentation] A Mathematical Model of Planar Cell Polarity (2016)
  • Author(s): M. Akiyama、T. Ayukawa、M. Yamazaki
  • Organizer: E.C.M.T.B.2016
  • Place of Presentation: Nottingham, UK
  • Year and Date: 2016-07-11
  • Int'l Joint Research
• [Presentation] 胸大動脈の背腹差について：マルチスケール力学解析とマイクロアレイ解析による検討 (2016)
  • Author(s): 松本健郎，杉田修啓，城野貴洋，飯島慎太郎，長山和亮，松本明郎
  • Organizer: 第55回日本生体医工学会大会
  • Place of Presentation: 富山県民会館（富山県富山市）
  • Year and Date: 2016-04-26
• [Presentation] The mechanism of Turing pattern formation in the zebrafish skin (2016)
  • Author(s): Shigeru Kondo
  • Organizer: NYUAD-CGSB Symposium
  • Place of Presentation: Abu Dhabi (United Arab Emirates)
  • Year and Date: 2016-02-24
  • Int'l Joint Research / Invited
• [Presentation] 胚断面高さおよびかたさ分布計測によるアフリカツメガエル脊索形成時の力学場の推定 (2016)
  • Author(s): 村上史哲，宮城明日香，杉田修啓，上野直人，松本健郎
  • Organizer: 日本機械学会第28回バイオエンジニアリング講演会
  • Place of Presentation: 東京工業大学（東京都）
  • Year and Date: 2016-01-09
• [Presentation] モデルなしのモデリング (2016)
  • Author(s): 近藤 滋
  • Organizer: 第26回非線形反応と共同現象研究会
  • Place of Presentation: 明治大学（東京都中野区）
  • Invited
• [Presentation] The detailed mechanism of Turing pattern formation in the skin of zebrafish (2016)
  • Author(s): Shigeru Kondo
  • Organizer: Combined ASBMB, ASPS and ANZSCDB Annual Meetings
  • Place of Presentation: Brisbane, Australia
  • Int'l Joint Research / Invited
• [Presentation] Simpler modelling of the biological pattern formation (2016)
  • Author(s): 近藤 滋
  • Organizer: 2016年日本数理生物学会年会
  • Place of Presentation: 九州大学（福岡県福岡市）
  • Invited
• [Presentation] 「シマウマは、縞模様を得たウマ、ではなく、均一中間色を失ったウマ、である」というお話し。 (2016)
  • Author(s): 近藤 滋
  • Organizer: 日本進化学会第18回大会
  • Place of Presentation: 東京工業大学（東京都目黒区）
  • Invited
• [Presentation] Measurement of force field during the collective cell migration of Xenopus embryonic cells (2016)
  • Author(s): Naoto Ueno
  • Organizer: 16th International Xenopus Conference
  • Place of Presentation: Orthodox Academy of Crete (OAC), Chania, Greece
  • Int'l Joint Research / Invited
• [Presentation] Discovery of cell chirality, a novel cell polarity, and its functions (2016)
  • Author(s): Kenji Matsuno
  • Organizer: 第３９回日本分子生物学会年会
  • Place of Presentation: パシフィコ横浜（神奈川県横浜市）
• [Presentation] Cell chirality my be an evolutionarily conserved mechanisms that drives twisting of alimentary canal (2016)
  • Author(s): Kenji Matsuno
  • Organizer: The 22nd International Congress of Zoology
  • Place of Presentation: 沖縄コンベンションセンター（沖縄県那覇市）
• [Presentation] Cell chirality is a novel and evolutionarily conserved cell polarity that drives left-right asymmetric morphogenesis (2016)
  • Author(s): Kenji Matsuno
  • Organizer: 57th annual Drosophila research conference
  • Place of Presentation: Orlando, USA
  • Int'l Joint Research
• [Presentation] 細胞外基質の粘弾性に応答する上皮細胞の集団運動と3次元形態形成 (2016)
  • Author(s): 芳賀 永
  • Organizer: 第54回日本生物物理学会年会シンポジウム
  • Place of Presentation: つくば国際会議場（茨城県つくば市）
  • Invited
• [Presentation] 3D morphogenesis of Drosophila leg from folded epithelial sheets during development (2016)
  • Author(s): Shizue Ohsawa, Megumi Nakayama, Tatsushi Igaki
  • Organizer: Joint meeting of the 22nd International Congress of Zoology (ICZ) & the 87th meeting of the ZSJ
  • Place of Presentation: 沖縄科学技術大学院大学（沖縄県国頭郡恩納村）
  • Invited
• [Book] 遺伝子発現制御機構 (2017)
  • Author(s): 稲木美紀子, 山川智子, 笹村剛司, 松野健治
  • Total Pages: 7
  • Publisher: 東京化学同人
• [Book] Vascular Engineering (Tanishita K and Yamamoto K, eds) (2016)
  • Author(s): Tanishita K, Yamamoto K, Sugihara-Seki M, Yamada H, Aoki T, Tada S, Tarbell JM, Kaunas R, Deguchi S, Ohashi T, Matsumoto T, Sugita S, Nagayama K, Kataoka N, Butler PJ, Kudo S, Goto S et al
  • Total Pages: 401
  • Publisher: Springer
• [Remarks] 3Dmorphologic 生命の３Ｄ形態を構築するロジック
  • URL: http://www.3d-logic.jp/
• [Remarks] パターン形成研究ＨＰ
  • URL: https://www.fbs-osaka-kondolabo.net/
• [Remarks] 「生物の３D形態を構築するロジック」ホームページ
  • URL: http://www.3d-logic.jp/index2.html
• [Remarks] ３D MORPHOLOGIC
  • URL: http://www.3d-logic.jp/en/
• [Remarks] 生物の３D形態を構築するロジック
  • URL: http://www.3d-logic.jp/index.html
• [Remarks] 3D MORPHOLOGIC
  • URL: http://www.3d-logic.jp/en/index.html
• [Remarks] 3D MORPHOLOGIC
  • URL: http://www.3d-logic.jp/en/
• [Remarks] Mechanobiology Institute
  • URL: http://mbi.nus.edu.sg/yusuke-toyama/
• [Remarks] Harvard University
  • URL: https://wiki.med.harvard.edu/SysBio/Megason/
• [Remarks] Kenji NIshida
  • URL: http://natgeo.nikkeibp.co.jp/nng/article/20110512/269654/
• [Patent(Industrial Property Rights)] ゲルの製造方法及びコラーゲンゲル (2018)
  • Inventor(s): 古澤 和也、芳賀 永、立花 真美
  • Industrial Property Rights Holder: 古澤 和也、芳賀 永、立花 真美
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2018-007402
  • Filing Date: 2018
• [Funded Workshop] Japan-Toronto Morphogenesis Symposium (2018)
• [Funded Workshop] JAPAN-UCI 3D Morphogenesis Meeting (2017)
• [Funded Workshop] The 4th Asia-Pacific Drosophila Research Conference (2017)
• [Funded Workshop] How does physics solve the biological questions? (2016)
  • Place of Presentation: 基礎生物学研究所
  • Year and Date: 2016-01-05