システム癌新次元国際連携支援

• Project Area: Conquering cancer through neo-dimensional systems understanding
• Project/Area Number: 15K21741
• Research Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
• Allocation Type: Multi-year Fund
• Review Section: Complex systems
• Research Institution: The University of Tokyo
• Principal Investigator: 宮野 悟 東京大学, 医科学研究所, 教授 (50128104)
• Project Period (FY): 2015-11-06 – 2021-03-31
• Project Status: Granted (Fiscal Year 2019)
• Budget Amount: ¥62,140,000 (Direct Cost: ¥47,800,000、Indirect Cost: ¥14,340,000); Fiscal Year 2019: ¥14,820,000 (Direct Cost: ¥11,400,000、Indirect Cost: ¥3,420,000); Fiscal Year 2018: ¥14,820,000 (Direct Cost: ¥11,400,000、Indirect Cost: ¥3,420,000); Fiscal Year 2017: ¥14,820,000 (Direct Cost: ¥11,400,000、Indirect Cost: ¥3,420,000); Fiscal Year 2016: ¥14,820,000 (Direct Cost: ¥11,400,000、Indirect Cost: ¥3,420,000); Fiscal Year 2015: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
• Keywords: がん / システム生物学 / ゲノム科学 / バイオインフォマティクス / 人工知能

Outline of Annual Research Achievements

相互派遣企画委員会(小川誠司)、国際共同研究推進委員会(稲澤譲治)において、議論を行い、海外研究機関からの研究者の招へいおよび海外研究機関への研究者の派遣を行うことにより、これまでに形成してきた国際共同研究拠点での研究活動の推進と深化、新たな国際共同研究ネットワーク形成を行った。
平成31年度は、6月～8月に大阪大学の大学院生を米国Icahn School of Medicine at Mount Sinaiに派遣し、疾患ゲノムデータ解析の国際共同研究とその拠点構築に当たった。9月には英国Sanger Instituteより研究者一名を招聘し、京都大学においてがんゲノミクスの共同研究打ち合わせを行った。10月には東京大学医科学研究所より5名をメキシコのCenter for Research & Advanced Studies (CRAS)に派遣し、すでに形成されているシステムズバイオロジーとがん研究に関する国際共同研究拠点での共同研究、並びにCRASからの要請によりバイオインフォマティクス・ハンズオン支援活動"Practices in Bioinformatics and Systems Biology"をメキシコ側参加者約30人を対象に実施した。2020年1月29日に、Sheraton Miyako Hotel Tokyoで国際会議International Conference on Cancer Systems Biology Beyondを開催し、米国・韓国カナダ・ドイツ・スウェーデンから、がん、システムズバイオロジー、ゲノム科学、ELSIの研究者7名を招聘した。数十名の国内の研究者も参加し、国際共同研究の推進を図った。この国際会議の前後において研究交流を実施した。

Current Status of Research Progress

3: Progress in research has been slightly delayed.

Reason

2020年になって当初予期していなかった新型コロナウイルス感染症パンデミックの懸念が発生し、国際共同研究支援活動を物理的に停止し、その活動を2020年度に延期せざるを得なくなったため。

Strategy for Future Research Activity

新型コロナウイルスパンデミックの国内外の状況をみながら、中断せざるを得なかった活動、並びにこれまでの企画の継続と更新を行い、海外の研究グループとの共同研究支援活動を行う。本年度は、3月に企画していた国際共同研究とアウトリーチのための国際会議が新型コロナウイルス感染症拡大防止のために延期となったため、来年度の開催に向けて準備を進める。また、新型コロナウィルスの影響で、そのほかの国際共同研究の交流が物理的にストップしてしまったため、来年度改めて推進・深化を図る。環境が許せば、必要に応じて若手研究者の海外への長期派遣や受け入れ、人工知能技術の調査と生命科学研究への導入も行う。

Research Products

• [Int'l Joint Research] Sanger Institute(英国)
• [Int'l Joint Research] Icahn School of Medicine at Mount Sinai/Harvard Medical School(米国)
• [Int'l Joint Research] カロリンスカ研究所(スウェーデン)
• [Int'l Joint Research] フンボルト大学(ドイツ)
• [Int'l Joint Research] Seoul National University/National Cancer Center(韓国)
• [Int'l Joint Research]
• [Int'l Joint Research] ミシガン大学(米国)
• [Int'l Joint Research] ヘルシンキ大学/カロリンスカ研究所(スウェーデン)
• [Int'l Joint Research] Sanger Institute(英国)
• [Int'l Joint Research] チュラロンコン大学(タイ)
• [Int'l Joint Research] The University of Hong Kong/The Chinese University of Hong Kong/City University of Honk Kong(中国)
• [Int'l Joint Research]
• [Int'l Joint Research] シカゴ大学/Harvard Medical School/Ichahn School of Medicine at Mount Sinai(米国)
• [Int'l Joint Research] カロリンスカ研究所(スウェーデン)
• [Int'l Joint Research] チュラロンコン大学(タイ)
• [Int'l Joint Research] The Wellcome Trust Sanger Institute(英国)
• [Int'l Joint Research] University of Ulsan College of Medicine/Seoul National University(韓国)
• [Int'l Joint Research] Chulalongkorn University(タイ)
• [Int'l Joint Research] The University of Chicago/Oklahoma University/Cleveland Clinic(米国)
• [Int'l Joint Research] Seoul National University(韓国)
• [Int'l Joint Research] Ontario Institute for Cancer Research(カナダ)
• [Int'l Joint Research] The Sanger Institute(英国)
• [Int'l Joint Research] The University of Chicago/IBM/Oklahoma University(USA)
• [Int'l Joint Research] Chinese Academy of Sciences(China)
• [Int'l Joint Research] Thammasat University(Thailand)
• [Int'l Joint Research] The University of Tampa(Finland)
• [Int'l Joint Research] Seoul National University(South Korea)
• [Presentation] On the origin of cancer (2020)
  • Author(s): Seishi Ogawa
  • Organizer: International Conference on Cancer Systems Biology Beyond
  • Int'l Joint Research / Invited
• [Presentation] Lung cancer biology: from genomes to function (2020)
  • Author(s): Matthew Meyerson
  • Organizer: International Conference on Cancer Systems Biology Beyond
  • Int'l Joint Research / Invited
• [Presentation] Divergent lncRNA MYMLR regulates MYC by eliciting DNA looping and promoter-enhancer interaction (2020)
  • Author(s): Takashi Takahashi
  • Organizer: International Conference on Cancer Systems Biology Beyond
  • Int'l Joint Research / Invited
• [Presentation] Mathematical modeling of metabolism in cancer and physical constraints for cell growth (2020)
  • Author(s): Edda Klipp
  • Organizer: International Conference on Cancer Systems Biology Beyond
  • Int'l Joint Research / Invited
• [Presentation] Deep Hidden Physics Modeling of Cell Signaling Networks (2020)
  • Author(s): Rune Linding
  • Organizer: International Conference on Cancer Systems Biology Beyond
  • Int'l Joint Research / Invited
• [Presentation] Exploring the genetics of population diversity to study hematological trait variation and diseases (2020)
  • Author(s): Guillaume Lettre
  • Organizer: International Conference on Cancer Systems Biology Beyond
  • Int'l Joint Research / Invited
• [Presentation] Statistical genetics, disease biology, and drug discovery (2020)
  • Author(s): Yukinori Okada
  • Organizer: International Conference on Cancer Systems Biology Beyond
  • Int'l Joint Research / Invited
• [Presentation] Systems Precision Medicine for Tailoring Treatments to Patients with Acute Myeloid Leukemia (2020)
  • Author(s): Olli Kallioniemi
  • Organizer: International Conference on Cancer Systems Biology Beyond
  • Int'l Joint Research / Invited
• [Presentation] MicroRNA Therapeutics in Precision Cancer Medicine (PCM) (2020)
  • Author(s): Johji Inazawa
  • Organizer: International Conference on Cancer Systems Biology Beyond
  • Int'l Joint Research / Invited
• [Presentation] Ethics of Cancer Genomics and Discrimination in East Asia: South Korean Experience and Beyond (2020)
  • Author(s): Ock-Joo Kim, Yoon-Jung Chang
  • Organizer: International Conference on Cancer Systems Biology Beyond
  • Int'l Joint Research / Invited
• [Presentation] What Public Concerns Exist Regarding Cancer Genomic Medicine? The Japanese Experience and Beyond (2020)
  • Author(s): Kaori Muto, Akiko Nagai
  • Organizer: International Conference on Cancer Systems Biology Beyond
  • Int'l Joint Research / Invited
• [Presentation] Integrative Nutriomics Approach for understanding Cancer and Metabolism (2020)
  • Author(s): Tsuyoshi Osawa
  • Organizer: International Conference on Cancer Systems Biology Beyond
  • Int'l Joint Research / Invited
• [Presentation] Cancer Big Data Challenges by Supercomputers and Artificial Intelligence (2020)
  • Author(s): Satoru Miyano
  • Organizer: International Conference on Cancer Systems Biology Beyond
  • Int'l Joint Research / Invited
• [Presentation] Cancer Big Data Analysis with Supercomputers (2019)
  • Author(s): Satoru Miyano
  • Organizer: The 2nd Workshop “PRACTICES IN BIOINFORMATICS AND SYSTEMS BIOLOGY”
  • Int'l Joint Research / Invited
• [Presentation] Genomon: A cancer genome mutation detection pipeline (2019)
  • Author(s): Kotoe Katayama
  • Organizer: The 2nd Workshop “PRACTICES IN BIOINFORMATICS AND SYSTEMS BIOLOGY”
  • Int'l Joint Research / Invited
• [Presentation] Computational Prediction of Gene Networks for Drug Target Discovery (2019)
  • Author(s): Seiya Imoto
  • Organizer: The 2nd Workshop “PRACTICES IN BIOINFORMATICS AND SYSTEMS BIOLOGY”
  • Int'l Joint Research / Invited
• [Presentation] Nanopore sequencing: from basecalling to structural variant detection (2019)
  • Author(s): Yaozhong Zhang
  • Organizer: The 2nd Workshop “PRACTICES IN BIOINFORMATICS AND SYSTEMS BIOLOGY”
  • Int'l Joint Research / Invited
• [Presentation] Flexible Bayesian Modeling for Accurate Mutation Calling from Multi-Regional Tumors (2019)
  • Author(s): Takuya Moriyama
  • Organizer: The 2nd Workshop “PRACTICES IN BIOINFORMATICS AND SYSTEMS BIOLOGY”
  • Int'l Joint Research / Invited
• [Presentation] Accelerating Cancer Clinical Sequence by Artificial Intelligence and Supercomputer (2018)
  • Author(s): 宮野 悟
  • Organizer: Seminar Precision Medicine in the 21st Century in Mexico
  • Int'l Joint Research / Invited
• [Remarks] システム癌新次元ホームページ
  • URL: http://neosystemscancer.hgc.jp/csbbeyond
• [Remarks] 国際会議"Cancer Systems Biology Beyond"ホームページ
  • URL: http://neosystemscancer.hgc.jp/csbbeyond
• [Remarks] 国際会議"ISPCM2020"ホームページ
  • URL: https://www2.aeplan.co.jp/ispcm2020/index.html
• [Remarks]
  • URL: http://neosystemscancer.hgc.jp/home
• [Remarks] 新学術領域「システム癌新次元」
  • URL: http://neosystemscancer.hgc.jp/
• [Remarks] システム癌新次元ホームページ
  • URL: http://neosystemscancer.hgc.jp/
• [Funded Workshop] International Conference on Cancer Systems Biology Beyond (2020)
• [Funded Workshop] II WORKSHOP “PRACTICES IN BIOINFORMATICS AND SYSTEMS BIOLOGY” (2019)
• [Funded Workshop] Joint Hong Kong-Japan Bioinformatics and Systems Biology Workshop (2018)
• [Funded Workshop] The Workshop on Bioinformatics at the Supercomputing Facility of Cinvestav (2018)
• [Funded Workshop] Precision Medicine in the 21st Century, El Colegio Nacional Mexico (2018)