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システム癌新次元国際連携支援

International

Project AreaConquering cancer through neo-dimensional systems understanding
Project/Area Number 15K21741
Research Category

Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

Allocation TypeMulti-year Fund
Review Section Complex systems
Research InstitutionTokyo Medical and Dental University (2020)
The University of Tokyo (2015-2019)

Principal Investigator

宮野 悟  東京医科歯科大学, M&Dデータ科学センター, 特任教授 (50128104)

Project Period (FY) 2015-11-06 – 2022-03-31
Project Status Granted (Fiscal Year 2020)
Budget Amount *help
¥62,140,000 (Direct Cost: ¥47,800,000、Indirect Cost: ¥14,340,000)
Fiscal Year 2019: ¥14,820,000 (Direct Cost: ¥11,400,000、Indirect Cost: ¥3,420,000)
Fiscal Year 2018: ¥14,820,000 (Direct Cost: ¥11,400,000、Indirect Cost: ¥3,420,000)
Fiscal Year 2017: ¥14,820,000 (Direct Cost: ¥11,400,000、Indirect Cost: ¥3,420,000)
Fiscal Year 2016: ¥14,820,000 (Direct Cost: ¥11,400,000、Indirect Cost: ¥3,420,000)
Fiscal Year 2015: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Keywordsがん / システム生物学 / ゲノム科学 / バイオインフォマティクス / 人工知能
Outline of Annual Research Achievements

COVID-19が想定外に収束せず、フェイス・ツー・フェイスの交流はできなかったが、小川誠司等のカロリンスカ研究所との交流は、データ解析を通じてほぼ順調に行われた。また、台湾、ドイツがん研究コンソーシアム、German Cancer Research Center、ヘルシンキ大学、米国Memorial Sloan Kettering Cancer Center等、共同研究の成果に到達できた。データ解析は、東京大学医科学研究所ヒトゲノム解析センターのスーパーコンピュータSHIROKANEこれまでと同様に活用した。また、これまでに構築したオンライン形式でのコミュニケーション設備等は有効にはたらき、その総合的研究成果を国際会議Recomb2020 Computational Molecular Biology Conference (2020年6月22日 – 2020年6月25日)では、基調講演として発表した(Miyano S: Cancer Big Data Challenges from Genomes to Networks)。

Current Status of Research Progress
Current Status of Research Progress

3: Progress in research has been slightly delayed.

Reason

2020年度に延期予定であったネットワーク構築のための国際会議等が最終的に中止にせざるを得なくなる中、これまでの活動で構築した研究者ネットワークはよりしっかりとしたものになった。特に、国際がんゲノムコンソーシアム関係者は、その研究成果の発表とともに強くつながった。

Strategy for Future Research Activity

これまでに構築した研究者ネットワークを若い世代へと継承していく。

Report

(6 results)
  • 2020 Research-status Report
  • 2019 Research-status Report
  • 2018 Research-status Report
  • 2017 Research-status Report
  • 2016 Research-status Report
  • 2015 Research-status Report

Research Products

(76 results)

All 2021 2020 2019 2018 Other

All Int'l Joint Research (32 results) Journal Article (8 results) (of which Int'l Joint Research: 8 results,  Peer Reviewed: 8 results,  Open Access: 4 results) Presentation (25 results) (of which Int'l Joint Research: 22 results,  Invited: 25 results) Remarks (6 results) Funded Workshop (5 results)

  • [Int'l Joint Research] カロリンスカ研究所(スウェーデン)

    • Related Report
      2020 Research-status Report
  • [Int'l Joint Research] Sanger Institute(英国)

    • Related Report
      2020 Research-status Report
  • [Int'l Joint Research] Icahn School of Medicine at Mount Sinai/Harvard Medical School(米国)

    • Related Report
      2020 Research-status Report
  • [Int'l Joint Research] フンボルト大学(ドイツ)

    • Related Report
      2020 Research-status Report
  • [Int'l Joint Research] Seoul National University/National Cancer Center(韓国)

    • Related Report
      2020 Research-status Report
  • [Int'l Joint Research] Sanger Institute(英国)

    • Related Report
      2019 Research-status Report
  • [Int'l Joint Research] Icahn School of Medicine at Mount Sinai/Harvard Medical School(米国)

    • Related Report
      2019 Research-status Report
  • [Int'l Joint Research] カロリンスカ研究所(スウェーデン)

    • Related Report
      2019 Research-status Report
  • [Int'l Joint Research] フンボルト大学(ドイツ)

    • Related Report
      2019 Research-status Report
  • [Int'l Joint Research] Seoul National University/National Cancer Center(韓国)

    • Related Report
      2019 Research-status Report
  • [Int'l Joint Research]

    • Related Report
      2019 Research-status Report
  • [Int'l Joint Research] ミシガン大学(米国)

    • Related Report
      2018 Research-status Report
  • [Int'l Joint Research] ヘルシンキ大学/カロリンスカ研究所(スウェーデン)

    • Related Report
      2018 Research-status Report
  • [Int'l Joint Research] Sanger Institute(英国)

    • Related Report
      2018 Research-status Report
  • [Int'l Joint Research] チュラロンコン大学(タイ)

    • Related Report
      2018 Research-status Report
  • [Int'l Joint Research] The University of Hong Kong/The Chinese University of Hong Kong/City University of Honk Kong(中国)

    • Related Report
      2018 Research-status Report
  • [Int'l Joint Research]

    • Related Report
      2018 Research-status Report
  • [Int'l Joint Research] シカゴ大学/Harvard Medical School/Ichahn School of Medicine at Mount Sinai(米国)

    • Related Report
      2017 Research-status Report
  • [Int'l Joint Research] カロリンスカ研究所(スウェーデン)

    • Related Report
      2017 Research-status Report
  • [Int'l Joint Research] チュラロンコン大学(タイ)

    • Related Report
      2017 Research-status Report
  • [Int'l Joint Research] The Wellcome Trust Sanger Institute(英国)

    • Related Report
      2017 Research-status Report
  • [Int'l Joint Research] University of Ulsan College of Medicine/Seoul National University(韓国)

    • Related Report
      2017 Research-status Report
  • [Int'l Joint Research] Chulalongkorn University(タイ)

    • Related Report
      2016 Research-status Report
  • [Int'l Joint Research] The University of Chicago/Oklahoma University/Cleveland Clinic(米国)

    • Related Report
      2016 Research-status Report
  • [Int'l Joint Research] Seoul National University(韓国)

    • Related Report
      2016 Research-status Report
  • [Int'l Joint Research] Ontario Institute for Cancer Research(カナダ)

    • Related Report
      2016 Research-status Report
  • [Int'l Joint Research] The Sanger Institute(英国)

    • Related Report
      2016 Research-status Report
  • [Int'l Joint Research] The University of Chicago/IBM/Oklahoma University(米国)

    • Related Report
      2015 Research-status Report
  • [Int'l Joint Research] Chinese Academy of Sciences(China)

    • Related Report
      2015 Research-status Report
  • [Int'l Joint Research] Thammasat University(Thailand)

    • Related Report
      2015 Research-status Report
  • [Int'l Joint Research] The University of Tampa(Finland)

    • Related Report
      2015 Research-status Report
  • [Int'l Joint Research] Seoul National University(韓国)

    • Related Report
      2015 Research-status Report
  • [Journal Article] Clonal evolution and clinical implications of genetic abnormalities in blastic transformation of chronic myeloid leukaemia2021

    • Author(s)
      Ochi Y, Yoshida K, Huang YJ, Kuo MC, Nannya Y, Sasaki K, Mitani K, Hosoya N, Hiramoto N, Ishikawa T, Ohyashiki K, Takahashi N, Takaku T, Tsuchiya S, Kanemura N, Nakamura N, Ueda Y, Yoshihara S, Watatani Y, Okuda R, Makishima H, Shiraishi Y, Chiba K, Tanaka H, Sanada M, Takaori-Kondo A, Miyano S, Ogawa S, Shih LY
    • Journal Title

      Nat Commun

      Volume: 12(1) Pages: 2833-2833

    • DOI

      10.1038/s41467-021-23097-w

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Somatic mutations in lymphocytes in patients with immune-mediated aplastic anemia2021

    • Author(s)
      Lundgren S, Kankainen M, Huuhtanen J, Walldin G, Kerr CM, Clemente M, Ebeling F, Rajala H, Brück O, Lähdesmäki H, Hannula S, Hannunen T, Ellonen P, Young NS, Ogawa S, Maciejewski JP, Hellström-Lindberg E, Mustjoki S
    • Journal Title

      Leukemia

      Volume: 35(5) Pages: 1365-1379

    • DOI

      10.1038/s41375-021-01231-3

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] A genetically defined signature of responsiveness to erlotinib in early-stage pancreatic cancer patients: Results from the CONKO-005 trial2021

    • Author(s)
      Hoyer K, Hablesreiter R, Inoue Y, Yoshida K, Briest F, Christen F, Kakiuchi N, Yoshizato T, Shiozawa Y, Shiraishi Y, Striefler JK, Bischoff S, Lohneis P, Putter H, Blau O, Keilholz U, Bullinger L, Pelzer U, Hummel M, Riess H, Ogawa S, Sinn M, Damm F
    • Journal Title

      EBioMedicine

      Volume: 66 Pages: 103327-103327

    • DOI

      10.1016/j.ebiom.2021.103327

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Discovery of Functional Alternatively Spliced PKM Transcripts in Human Cancers2021

    • Author(s)
      Li X, Kim W, Arif M, Gao C, Hober A, Kotol D, Strandberg L, Forsström B, Sivertsson Å, Oksvold P, Turkez H, Grøtli M, Sato Y, Kume H, Ogawa S, Boren J, Nielsen J, Uhlen M, Zhang C, Mardinoglu A
    • Journal Title

      Cancers

      Volume: 13(2) Pages: 348-348

    • DOI

      10.3390/cancers13020348

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Frequent mutations in HLA and related genes in extranodal NK/T cell lymphomas. Leuk Lymphoma2021

    • Author(s)
      Polprasert C, Takeuchi Y, Makishima H, Wudhikarn K, Kakiuchi N, Tangnuntachai N, Assanasen T, Sitthi W, Muhamad H, Lawasut P, Kongkiatkamon S, Bunworasate U, Izutsu K, Shiraishi Y, Chiba K, Tanaka H, Miyano S, Ogawa S, Yoshida K, Rojnuckarin P
    • Journal Title

      Leukemia & Lymphoma

      Volume: 62(1) Pages: 95-103

    • DOI

      10.1080/10428194.2020.1821011

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Co-mutation pattern, clonal hierarchy, and clone size concur to determine disease phenotype of SRSF2P95-mutated neoplasms2020

    • Author(s)
      Todisco G, Creignou M, Guglielmelli P, Rumi E, Roncador M, Rizzo E, Nannya Y, Pietra D, Elena C, Bono E, Molteni E, Rosti V, Catricalá S, Sarchi M, Dimitriou M, Ungerstedt J, Vannucchi AM, Hellström-Lindberg E, Ogawa S, Cazzola M, Malcovati L
    • Journal Title

      Leukemia

      Volume: ??

    • DOI

      10.1038/s41375-020-01106-z

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Two aldehyde clearance systems are essential to prevent lethal formaldehyde accumulation in mice and humans.2020

    • Author(s)
      Dingler FA†, Wang M†, Mu A† (Co-first), ....Takata M, Patel KJ.
    • Journal Title

      Molecular Cell

      Volume: 80 Pages: 996-1012

    • DOI

      10.1016/j.molcel.2020.10.012

    • NAID

      120006951779

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Implications of TP53 allelic state for genome stability, clinical presentation and outcomes in myelodysplastic syndromes2020

    • Author(s)
      Bernard E, Nannya Y, Hasserjian RP, Ogawa S, Papaemmanuil E
    • Journal Title

      Nature Medicine

      Volume: 26(10) Pages: 1549-1556

    • DOI

      10.1038/s41591-020-1008-z

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] AIで支援する臨床ゲノム解析2021

    • Author(s)
      宮野 悟
    • Organizer
      日本がん分子標的治療学会TRワークショップ
    • Related Report
      2020 Research-status Report
    • Invited
  • [Presentation] がん研究・医療とAIに関わる進捗と課題2021

    • Author(s)
      宮野 悟
    • Organizer
      第17回日本婦人科がん会議
    • Related Report
      2020 Research-status Report
    • Invited
  • [Presentation] Digesting Cancer Big Networks by Explainable AI and Supercomputers2021

    • Author(s)
      Satoru Miyano
    • Organizer
      The 3rd R-CCS International Symposium
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] AIでがんのゲノム医療はどこまで的確にかつ効率的になるのか2021

    • Author(s)
      宮野 悟
    • Organizer
      第85回日本循環器学会_第三回医療AIコンテスト
    • Related Report
      2020 Research-status Report
    • Invited
  • [Presentation] Cancer Big Data Challenges from Genomes to Networks2020

    • Author(s)
      Satoru Miyano
    • Organizer
      The 24th International Conference on Research in Computational Molecular Biology
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] がん研究・医療のための自然言語処理と説明可能 AI2020

    • Author(s)
      宮野 悟
    • Organizer
      第79回日本癌学会学術集会
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] On the origin of cancer2020

    • Author(s)
      Seishi Ogawa
    • Organizer
      International Conference on Cancer Systems Biology Beyond
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Lung cancer biology: from genomes to function2020

    • Author(s)
      Matthew Meyerson
    • Organizer
      International Conference on Cancer Systems Biology Beyond
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Divergent lncRNA MYMLR regulates MYC by eliciting DNA looping and promoter-enhancer interaction2020

    • Author(s)
      Takashi Takahashi
    • Organizer
      International Conference on Cancer Systems Biology Beyond
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Mathematical modeling of metabolism in cancer and physical constraints for cell growth2020

    • Author(s)
      Edda Klipp
    • Organizer
      International Conference on Cancer Systems Biology Beyond
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Deep Hidden Physics Modeling of Cell Signaling Networks2020

    • Author(s)
      Rune Linding
    • Organizer
      International Conference on Cancer Systems Biology Beyond
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Exploring the genetics of population diversity to study hematological trait variation and diseases2020

    • Author(s)
      Guillaume Lettre
    • Organizer
      International Conference on Cancer Systems Biology Beyond
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Statistical genetics, disease biology, and drug discovery2020

    • Author(s)
      Yukinori Okada
    • Organizer
      International Conference on Cancer Systems Biology Beyond
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Systems Precision Medicine for Tailoring Treatments to Patients with Acute Myeloid Leukemia2020

    • Author(s)
      Olli Kallioniemi
    • Organizer
      International Conference on Cancer Systems Biology Beyond
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] MicroRNA Therapeutics in Precision Cancer Medicine (PCM)2020

    • Author(s)
      Johji Inazawa
    • Organizer
      International Conference on Cancer Systems Biology Beyond
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Ethics of Cancer Genomics and Discrimination in East Asia: South Korean Experience and Beyond2020

    • Author(s)
      Ock-Joo Kim, Yoon-Jung Chang
    • Organizer
      International Conference on Cancer Systems Biology Beyond
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] What Public Concerns Exist Regarding Cancer Genomic Medicine? The Japanese Experience and Beyond2020

    • Author(s)
      Kaori Muto, Akiko Nagai
    • Organizer
      International Conference on Cancer Systems Biology Beyond
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Integrative Nutriomics Approach for understanding Cancer and Metabolism2020

    • Author(s)
      Tsuyoshi Osawa
    • Organizer
      International Conference on Cancer Systems Biology Beyond
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Cancer Big Data Challenges by Supercomputers and Artificial Intelligence2020

    • Author(s)
      Satoru Miyano
    • Organizer
      International Conference on Cancer Systems Biology Beyond
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Cancer Big Data Analysis with Supercomputers2019

    • Author(s)
      Satoru Miyano
    • Organizer
      The 2nd Workshop “PRACTICES IN BIOINFORMATICS AND SYSTEMS BIOLOGY”
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Genomon: A cancer genome mutation detection pipeline2019

    • Author(s)
      Kotoe Katayama
    • Organizer
      The 2nd Workshop “PRACTICES IN BIOINFORMATICS AND SYSTEMS BIOLOGY”
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Computational Prediction of Gene Networks for Drug Target Discovery2019

    • Author(s)
      Seiya Imoto
    • Organizer
      The 2nd Workshop “PRACTICES IN BIOINFORMATICS AND SYSTEMS BIOLOGY”
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Nanopore sequencing: from basecalling to structural variant detection2019

    • Author(s)
      Yaozhong Zhang
    • Organizer
      The 2nd Workshop “PRACTICES IN BIOINFORMATICS AND SYSTEMS BIOLOGY”
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Flexible Bayesian Modeling for Accurate Mutation Calling from Multi-Regional Tumors2019

    • Author(s)
      Takuya Moriyama
    • Organizer
      The 2nd Workshop “PRACTICES IN BIOINFORMATICS AND SYSTEMS BIOLOGY”
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Accelerating Cancer Clinical Sequence by Artificial Intelligence and Supercomputer2018

    • Author(s)
      宮野 悟
    • Organizer
      Seminar Precision Medicine in the 21st Century in Mexico
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research / Invited
  • [Remarks] システム癌新次元ホームページ

    • URL

      http://neosystemscancer.hgc.jp/

    • Related Report
      2020 Research-status Report
  • [Remarks] システム癌新次元ホームページ

    • URL

      http://neosystemscancer.hgc.jp/csbbeyond

    • Related Report
      2019 Research-status Report
  • [Remarks] 国際会議"Cancer Systems Biology Beyond"ホームページ

    • URL

      http://neosystemscancer.hgc.jp/csbbeyond

    • Related Report
      2019 Research-status Report
  • [Remarks] 国際会議"ISPCM2020"ホームページ

    • URL

      https://www2.aeplan.co.jp/ispcm2020/index.html

    • Related Report
      2019 Research-status Report
  • [Remarks]

    • URL

      http://neosystemscancer.hgc.jp/home

    • Related Report
      2018 Research-status Report
  • [Remarks] 新学術領域「システム癌新次元」

    • URL

      http://neosystemscancer.hgc.jp/

    • Related Report
      2017 Research-status Report
  • [Funded Workshop] International Conference on Cancer Systems Biology Beyond2020

    • Related Report
      2019 Research-status Report
  • [Funded Workshop] II WORKSHOP “PRACTICES IN BIOINFORMATICS AND SYSTEMS BIOLOGY”2019

    • Related Report
      2019 Research-status Report
  • [Funded Workshop] Joint Hong Kong-Japan Bioinformatics and Systems Biology Workshop2018

    • Related Report
      2018 Research-status Report
  • [Funded Workshop] The Workshop on Bioinformatics at the Supercomputing Facility of Cinvestav2018

    • Related Report
      2018 Research-status Report
  • [Funded Workshop] Precision Medicine in the 21st Century, El Colegio Nacional Mexico2018

    • Related Report
      2018 Research-status Report

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Published: 2015-11-10   Modified: 2022-02-07  

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