システム癌新次元国際連携支援

• Project Area: Conquering cancer through neo-dimensional systems understanding
• Project/Area Number: 15K21741
• Research Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
• Allocation Type: Multi-year Fund
• Review Section: Complex systems
• Research Institution: Tokyo Medical and Dental University (2020); The University of Tokyo (2015-2019)
• Principal Investigator: 宮野 悟 東京医科歯科大学, M&Dデータ科学センター, 特任教授 (50128104)
• Project Period (FY): 2015-11-06 – 2022-03-31
• Project Status: Granted (Fiscal Year 2020)
• Budget Amount: ¥62,140,000 (Direct Cost: ¥47,800,000、Indirect Cost: ¥14,340,000); Fiscal Year 2019: ¥14,820,000 (Direct Cost: ¥11,400,000、Indirect Cost: ¥3,420,000); Fiscal Year 2018: ¥14,820,000 (Direct Cost: ¥11,400,000、Indirect Cost: ¥3,420,000); Fiscal Year 2017: ¥14,820,000 (Direct Cost: ¥11,400,000、Indirect Cost: ¥3,420,000); Fiscal Year 2016: ¥14,820,000 (Direct Cost: ¥11,400,000、Indirect Cost: ¥3,420,000); Fiscal Year 2015: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
• Keywords: がん / システム生物学 / ゲノム科学 / バイオインフォマティクス / 人工知能

Outline of Annual Research Achievements

COVID-19が想定外に収束せず、フェイス・ツー・フェイスの交流はできなかったが、小川誠司等のカロリンスカ研究所との交流は、データ解析を通じてほぼ順調に行われた。また、台湾、ドイツがん研究コンソーシアム、German Cancer Research Center、ヘルシンキ大学、米国Memorial Sloan Kettering Cancer Center等、共同研究の成果に到達できた。データ解析は、東京大学医科学研究所ヒトゲノム解析センターのスーパーコンピュータSHIROKANEこれまでと同様に活用した。また、これまでに構築したオンライン形式でのコミュニケーション設備等は有効にはたらき、その総合的研究成果を国際会議Recomb2020 Computational Molecular Biology Conference　(2020年6月22日 – 2020年6月25日)では、基調講演として発表した（Miyano S: Cancer Big Data Challenges from Genomes to Networks）。

Current Status of Research Progress

3: Progress in research has been slightly delayed.

Reason

2020年度に延期予定であったネットワーク構築のための国際会議等が最終的に中止にせざるを得なくなる中、これまでの活動で構築した研究者ネットワークはよりしっかりとしたものになった。特に、国際がんゲノムコンソーシアム関係者は、その研究成果の発表とともに強くつながった。

Strategy for Future Research Activity

これまでに構築した研究者ネットワークを若い世代へと継承していく。

Research Products

• [Int'l Joint Research] カロリンスカ研究所(スウェーデン)
• [Int'l Joint Research] Sanger Institute(英国)
• [Int'l Joint Research] Icahn School of Medicine at Mount Sinai/Harvard Medical School(米国)
• [Int'l Joint Research] フンボルト大学(ドイツ)
• [Int'l Joint Research] Seoul National University/National Cancer Center(韓国)
• [Int'l Joint Research] Sanger Institute(英国)
• [Int'l Joint Research] Icahn School of Medicine at Mount Sinai/Harvard Medical School(米国)
• [Int'l Joint Research] カロリンスカ研究所(スウェーデン)
• [Int'l Joint Research] フンボルト大学(ドイツ)
• [Int'l Joint Research] Seoul National University/National Cancer Center(韓国)
• [Int'l Joint Research]
• [Int'l Joint Research] ミシガン大学(米国)
• [Int'l Joint Research] ヘルシンキ大学/カロリンスカ研究所(スウェーデン)
• [Int'l Joint Research] Sanger Institute(英国)
• [Int'l Joint Research] チュラロンコン大学(タイ)
• [Int'l Joint Research] The University of Hong Kong/The Chinese University of Hong Kong/City University of Honk Kong(中国)
• [Int'l Joint Research]
• [Int'l Joint Research] シカゴ大学/Harvard Medical School/Ichahn School of Medicine at Mount Sinai(米国)
• [Int'l Joint Research] カロリンスカ研究所(スウェーデン)
• [Int'l Joint Research] チュラロンコン大学(タイ)
• [Int'l Joint Research] The Wellcome Trust Sanger Institute(英国)
• [Int'l Joint Research] University of Ulsan College of Medicine/Seoul National University(韓国)
• [Int'l Joint Research] Chulalongkorn University(タイ)
• [Int'l Joint Research] The University of Chicago/Oklahoma University/Cleveland Clinic(米国)
• [Int'l Joint Research] Seoul National University(韓国)
• [Int'l Joint Research] Ontario Institute for Cancer Research(カナダ)
• [Int'l Joint Research] The Sanger Institute(英国)
• [Int'l Joint Research] The University of Chicago/IBM/Oklahoma University(米国)
• [Int'l Joint Research] Chinese Academy of Sciences(China)
• [Int'l Joint Research] Thammasat University(Thailand)
• [Int'l Joint Research] The University of Tampa(Finland)
• [Int'l Joint Research] Seoul National University(韓国)
• [Journal Article] Clonal evolution and clinical implications of genetic abnormalities in blastic transformation of chronic myeloid leukaemia (2021)
  • Author(s): Ochi Y, Yoshida K, Huang YJ, Kuo MC, Nannya Y, Sasaki K, Mitani K, Hosoya N, Hiramoto N, Ishikawa T, Ohyashiki K, Takahashi N, Takaku T, Tsuchiya S, Kanemura N, Nakamura N, Ueda Y, Yoshihara S, Watatani Y, Okuda R, Makishima H, Shiraishi Y, Chiba K, Tanaka H, Sanada M, Takaori-Kondo A, Miyano S, Ogawa S, Shih LY
  • Journal Title: Nat Commun Volume: 12(1) Pages: 2833-2833
  • DOI: 10.1038/s41467-021-23097-w
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Somatic mutations in lymphocytes in patients with immune-mediated aplastic anemia (2021)
  • Author(s): Lundgren S, Kankainen M, Huuhtanen J, Walldin G, Kerr CM, Clemente M, Ebeling F, Rajala H, Brück O, Lähdesmäki H, Hannula S, Hannunen T, Ellonen P, Young NS, Ogawa S, Maciejewski JP, Hellström-Lindberg E, Mustjoki S
  • Journal Title: Leukemia Volume: 35(5) Pages: 1365-1379
  • DOI: 10.1038/s41375-021-01231-3
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] A genetically defined signature of responsiveness to erlotinib in early-stage pancreatic cancer patients: Results from the CONKO-005 trial (2021)
  • Author(s): Hoyer K, Hablesreiter R, Inoue Y, Yoshida K, Briest F, Christen F, Kakiuchi N, Yoshizato T, Shiozawa Y, Shiraishi Y, Striefler JK, Bischoff S, Lohneis P, Putter H, Blau O, Keilholz U, Bullinger L, Pelzer U, Hummel M, Riess H, Ogawa S, Sinn M, Damm F
  • Journal Title: EBioMedicine Volume: 66 Pages: 103327-103327
  • DOI: 10.1016/j.ebiom.2021.103327
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Discovery of Functional Alternatively Spliced PKM Transcripts in Human Cancers (2021)
  • Author(s): Li X, Kim W, Arif M, Gao C, Hober A, Kotol D, Strandberg L, Forsström B, Sivertsson Å, Oksvold P, Turkez H, Grøtli M, Sato Y, Kume H, Ogawa S, Boren J, Nielsen J, Uhlen M, Zhang C, Mardinoglu A
  • Journal Title: Cancers Volume: 13(2) Pages: 348-348
  • DOI: 10.3390/cancers13020348
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Frequent mutations in HLA and related genes in extranodal NK/T cell lymphomas. Leuk Lymphoma (2021)
  • Author(s): Polprasert C, Takeuchi Y, Makishima H, Wudhikarn K, Kakiuchi N, Tangnuntachai N, Assanasen T, Sitthi W, Muhamad H, Lawasut P, Kongkiatkamon S, Bunworasate U, Izutsu K, Shiraishi Y, Chiba K, Tanaka H, Miyano S, Ogawa S, Yoshida K, Rojnuckarin P
  • Journal Title: Leukemia & Lymphoma Volume: 62(1) Pages: 95-103
  • DOI: 10.1080/10428194.2020.1821011
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Co-mutation pattern, clonal hierarchy, and clone size concur to determine disease phenotype of SRSF2P95-mutated neoplasms (2020)
  • Author(s): Todisco G, Creignou M, Guglielmelli P, Rumi E, Roncador M, Rizzo E, Nannya Y, Pietra D, Elena C, Bono E, Molteni E, Rosti V, Catricalá S, Sarchi M, Dimitriou M, Ungerstedt J, Vannucchi AM, Hellström-Lindberg E, Ogawa S, Cazzola M, Malcovati L
  • Journal Title: Leukemia Volume: ??
  • DOI: 10.1038/s41375-020-01106-z
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Two aldehyde clearance systems are essential to prevent lethal formaldehyde accumulation in mice and humans. (2020)
  • Author(s): Dingler FA†, Wang M†, Mu A† (Co-first), ....Takata M, Patel KJ.
  • Journal Title: Molecular Cell Volume: 80 Pages: 996-1012
  • DOI: 10.1016/j.molcel.2020.10.012
  • NAID: 120006951779
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Implications of TP53 allelic state for genome stability, clinical presentation and outcomes in myelodysplastic syndromes (2020)
  • Author(s): Bernard E, Nannya Y, Hasserjian RP, Ogawa S, Papaemmanuil E
  • Journal Title: Nature Medicine Volume: 26(10) Pages: 1549-1556
  • DOI: 10.1038/s41591-020-1008-z
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Presentation] AIで支援する臨床ゲノム解析 (2021)
  • Author(s): 宮野 悟
  • Organizer: 日本がん分子標的治療学会TRワークショップ
  • Invited
• [Presentation] がん研究・医療とAIに関わる進捗と課題 (2021)
  • Author(s): 宮野 悟
  • Organizer: 第17回日本婦人科がん会議
  • Invited
• [Presentation] Digesting Cancer Big Networks by Explainable AI and Supercomputers (2021)
  • Author(s): Satoru Miyano
  • Organizer: The 3rd R-CCS International Symposium
  • Int'l Joint Research / Invited
• [Presentation] AIでがんのゲノム医療はどこまで的確にかつ効率的になるのか (2021)
  • Author(s): 宮野 悟
  • Organizer: 第85回日本循環器学会_第三回医療AIコンテスト
  • Invited
• [Presentation] Cancer Big Data Challenges from Genomes to Networks (2020)
  • Author(s): Satoru Miyano
  • Organizer: The 24th International Conference on Research in Computational Molecular Biology
  • Int'l Joint Research / Invited
• [Presentation] がん研究・医療のための自然言語処理と説明可能 AI (2020)
  • Author(s): 宮野 悟
  • Organizer: 第79回日本癌学会学術集会
  • Int'l Joint Research / Invited
• [Presentation] On the origin of cancer (2020)
  • Author(s): Seishi Ogawa
  • Organizer: International Conference on Cancer Systems Biology Beyond
  • Int'l Joint Research / Invited
• [Presentation] Lung cancer biology: from genomes to function (2020)
  • Author(s): Matthew Meyerson
  • Organizer: International Conference on Cancer Systems Biology Beyond
  • Int'l Joint Research / Invited
• [Presentation] Divergent lncRNA MYMLR regulates MYC by eliciting DNA looping and promoter-enhancer interaction (2020)
  • Author(s): Takashi Takahashi
  • Organizer: International Conference on Cancer Systems Biology Beyond
  • Int'l Joint Research / Invited
• [Presentation] Mathematical modeling of metabolism in cancer and physical constraints for cell growth (2020)
  • Author(s): Edda Klipp
  • Organizer: International Conference on Cancer Systems Biology Beyond
  • Int'l Joint Research / Invited
• [Presentation] Deep Hidden Physics Modeling of Cell Signaling Networks (2020)
  • Author(s): Rune Linding
  • Organizer: International Conference on Cancer Systems Biology Beyond
  • Int'l Joint Research / Invited
• [Presentation] Exploring the genetics of population diversity to study hematological trait variation and diseases (2020)
  • Author(s): Guillaume Lettre
  • Organizer: International Conference on Cancer Systems Biology Beyond
  • Int'l Joint Research / Invited
• [Presentation] Statistical genetics, disease biology, and drug discovery (2020)
  • Author(s): Yukinori Okada
  • Organizer: International Conference on Cancer Systems Biology Beyond
  • Int'l Joint Research / Invited
• [Presentation] Systems Precision Medicine for Tailoring Treatments to Patients with Acute Myeloid Leukemia (2020)
  • Author(s): Olli Kallioniemi
  • Organizer: International Conference on Cancer Systems Biology Beyond
  • Int'l Joint Research / Invited
• [Presentation] MicroRNA Therapeutics in Precision Cancer Medicine (PCM) (2020)
  • Author(s): Johji Inazawa
  • Organizer: International Conference on Cancer Systems Biology Beyond
  • Int'l Joint Research / Invited
• [Presentation] Ethics of Cancer Genomics and Discrimination in East Asia: South Korean Experience and Beyond (2020)
  • Author(s): Ock-Joo Kim, Yoon-Jung Chang
  • Organizer: International Conference on Cancer Systems Biology Beyond
  • Int'l Joint Research / Invited
• [Presentation] What Public Concerns Exist Regarding Cancer Genomic Medicine? The Japanese Experience and Beyond (2020)
  • Author(s): Kaori Muto, Akiko Nagai
  • Organizer: International Conference on Cancer Systems Biology Beyond
  • Int'l Joint Research / Invited
• [Presentation] Integrative Nutriomics Approach for understanding Cancer and Metabolism (2020)
  • Author(s): Tsuyoshi Osawa
  • Organizer: International Conference on Cancer Systems Biology Beyond
  • Int'l Joint Research / Invited
• [Presentation] Cancer Big Data Challenges by Supercomputers and Artificial Intelligence (2020)
  • Author(s): Satoru Miyano
  • Organizer: International Conference on Cancer Systems Biology Beyond
  • Int'l Joint Research / Invited
• [Presentation] Cancer Big Data Analysis with Supercomputers (2019)
  • Author(s): Satoru Miyano
  • Organizer: The 2nd Workshop “PRACTICES IN BIOINFORMATICS AND SYSTEMS BIOLOGY”
  • Int'l Joint Research / Invited
• [Presentation] Genomon: A cancer genome mutation detection pipeline (2019)
  • Author(s): Kotoe Katayama
  • Organizer: The 2nd Workshop “PRACTICES IN BIOINFORMATICS AND SYSTEMS BIOLOGY”
  • Int'l Joint Research / Invited
• [Presentation] Computational Prediction of Gene Networks for Drug Target Discovery (2019)
  • Author(s): Seiya Imoto
  • Organizer: The 2nd Workshop “PRACTICES IN BIOINFORMATICS AND SYSTEMS BIOLOGY”
  • Int'l Joint Research / Invited
• [Presentation] Nanopore sequencing: from basecalling to structural variant detection (2019)
  • Author(s): Yaozhong Zhang
  • Organizer: The 2nd Workshop “PRACTICES IN BIOINFORMATICS AND SYSTEMS BIOLOGY”
  • Int'l Joint Research / Invited
• [Presentation] Flexible Bayesian Modeling for Accurate Mutation Calling from Multi-Regional Tumors (2019)
  • Author(s): Takuya Moriyama
  • Organizer: The 2nd Workshop “PRACTICES IN BIOINFORMATICS AND SYSTEMS BIOLOGY”
  • Int'l Joint Research / Invited
• [Presentation] Accelerating Cancer Clinical Sequence by Artificial Intelligence and Supercomputer (2018)
  • Author(s): 宮野 悟
  • Organizer: Seminar Precision Medicine in the 21st Century in Mexico
  • Int'l Joint Research / Invited
• [Remarks] システム癌新次元ホームページ
  • URL: http://neosystemscancer.hgc.jp/
• [Remarks] システム癌新次元ホームページ
  • URL: http://neosystemscancer.hgc.jp/csbbeyond
• [Remarks] 国際会議"Cancer Systems Biology Beyond"ホームページ
  • URL: http://neosystemscancer.hgc.jp/csbbeyond
• [Remarks] 国際会議"ISPCM2020"ホームページ
  • URL: https://www2.aeplan.co.jp/ispcm2020/index.html
• [Remarks]
  • URL: http://neosystemscancer.hgc.jp/home
• [Remarks] 新学術領域「システム癌新次元」
  • URL: http://neosystemscancer.hgc.jp/
• [Funded Workshop] International Conference on Cancer Systems Biology Beyond (2020)
• [Funded Workshop] II WORKSHOP “PRACTICES IN BIOINFORMATICS AND SYSTEMS BIOLOGY” (2019)
• [Funded Workshop] Joint Hong Kong-Japan Bioinformatics and Systems Biology Workshop (2018)
• [Funded Workshop] The Workshop on Bioinformatics at the Supercomputing Facility of Cinvestav (2018)
• [Funded Workshop] Precision Medicine in the 21st Century, El Colegio Nacional Mexico (2018)