International Activities Support for Autophagy Research

• Project Area: Multidisciplinary research on autophagy: from molecular mechanisms to disease states
• Project/Area Number: 15K21749
• Research Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
• Allocation Type: Multi-year Fund
• Review Section: Biological Sciences
• Research Institution: The University of Tokyo
• Principal Investigator: Mizushima Noboru 東京大学, 大学院医学系研究科(医学部), 教授 (10353434)
• Co-Investigator(Kenkyū-buntansha): 吉森 保 大阪大学, 生命機能研究科, 教授 (60191649) ; 小松 雅明 新潟大学, 医歯学系, 教授 (90356254) ; 中戸川 仁 東京工業大学, 生命理工学院, 准教授 (90414010) ; 野田 展生 公益財団法人微生物化学研究会, 微生物化学研究所, 部長 (40396297) ; 斉木 臣二 順天堂大学, 医学部, 准教授 (00339996)
• Project Period (FY): 2015-11-06 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥49,140,000 (Direct Cost: ¥37,800,000、Indirect Cost: ¥11,340,000); Fiscal Year 2017: ¥16,380,000 (Direct Cost: ¥12,600,000、Indirect Cost: ¥3,780,000); Fiscal Year 2016: ¥16,380,000 (Direct Cost: ¥12,600,000、Indirect Cost: ¥3,780,000); Fiscal Year 2015: ¥16,380,000 (Direct Cost: ¥12,600,000、Indirect Cost: ¥3,780,000)
• Keywords: オートファジー / 細胞内分解 / リソソーム

Outline of Final Research Achievements

This Grant-in-Aid for Scientific Research on Innovative Areas was established to promote multidisciplinary research on autophagy by coordinating in vitro reconstitution biology, structural biology, cell biology, genetics of model organisms, and human pathophysiology. This "International Activities Supporting Group" set up Researcher Exchange Program Committee and Collaboration Promoting Committee. Aiming to promote bilateral joint research or international collaboration, our focus was on placing Japanese researchers overseas and on inviting or employing foreign researchers

Research Products

• [Int'l Joint Research] マックスプランク研究所/デュッセルドルフ大学(ドイツ)
• [Int'l Joint Research] 中国科学アカデミー/中国農業科学院ハルビン獣医学研究所/精華大学(中国)
• [Int'l Joint Research] シンシナティ大学/ワシントン大学/アルバート・アインシュタイン大学(米国)
• [Int'l Joint Research] ハンガリー科学アカデミー(ハンガリー)
• [Int'l Joint Research] バブラハム研究所/Beatson研究所/フランシス・クリック研究所(英国)
• [Int'l Joint Research]
• [Int'l Joint Research] マックスプランク研究所/ミュンスター大学/ゲーテ大学(ドイツ)
• [Int'l Joint Research] 中国科学アカデミー/ハルピン大学/清華大学(中国)
• [Int'l Joint Research] シンシナティ大学/ワシントン大学/アルバート・アインシュタイン大学(米国)
• [Int'l Joint Research] ヘルシンキ大学(フィンランド)
• [Int'l Joint Research] TIGM(イタリア)
• [Int'l Joint Research] デュッセルドルフ大学(ドイツ)
• [Int'l Joint Research] 中国アカデミー Institute of Biophysics(中国)
• [Int'l Joint Research] シンシナティ大学(米国)
• [Int'l Joint Research] Telethon Inst. of Genetics & Medicine(イタリア)
• [Journal Article] Systematic analysis of ATG13 domain requirements for autophagy induction (2018)
  • Author(s): Wallot-Hieke Nora、Verma Neha、Schluetermann David、Berleth Niklas、Deitersen Jana、Boehler Philip、Stuhldreier Fabian、Wu Wenxian、Seggewiss Sabine、Peter Christoph、Gohlke Holger、Mizushima Noboru、Stork Bjoern
  • Journal Title: Autophagy Volume: 21 Issue: 5 Pages: 1-21
  • DOI: 10.1080/15548627.2017.1387342
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Biallelic UFM1 and UFC1 mutations expand the essential role of ufmylation in brain development. (2018)
  • Author(s): Nahorski, MS, et al.
  • Journal Title: Brain Volume: 印刷中
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Fusion and scission of membranes: Ubiquitous topological transformations in cells (2017)
  • Author(s): Knorr Roland L.、Mizushima Noboru、Dimova Rumiana
  • Journal Title: Traffic Volume: 18 Issue: 11 Pages: 758-761
  • DOI: 10.1111/tra.12509
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Molecular definitions of autophagy and related processes. (2017)
  • Author(s): Galluzzi, L. et al.
  • Journal Title: EMBO J. Volume: 36 Issue: 13 Pages: 1811-1836
  • DOI: 10.15252/embj.201796697
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Small differences make a big impact: Structural insights into the differential function of the 2 Atg8 homologs in C. elegans. (2016)
  • Author(s): Wu, F., Wang, P., Shen, Y., Noda, N. N., Zhang, H.
  • Journal Title: Autophagy Volume: 12 Issue: 3 Pages: 606-607
  • DOI: 10.1080/15548627.2015.1137413
  • Int'l Joint Research
• [Presentation] Physiological roles and molecular mechanisms of autophagy (2018)
  • Author(s): Noboru Mizushima
  • Organizer: The 1st JCS Council Forum on Basic CadioVascular Research
  • Int'l Joint Research
• [Presentation] The life of the autophagosome: Formation and maturation (2018)
  • Author(s): Noboru Mizushima
  • Organizer: The 6th Bioscience and Biotechnology International Symposium
  • Int'l Joint Research / Invited
• [Presentation] Autophagy: From Yeast to Nobel Prize (2018)
  • Author(s): Noboru Mizushima
  • Organizer: Gordon Research Seminar,Autophagy in Stress, Development & Disease
  • Int'l Joint Research
• [Presentation] Novel Roles of Autophagy in Vertebrate Development (2018)
  • Author(s): Noboru Mizushima
  • Organizer: Gordon Research Conference, Autophagy in Stress, Development & Disease
  • Int'l Joint Research / Invited
• [Presentation] Novel Methods for Monitoring Autophagosome Maturation and Autophagic Flux (2017)
  • Author(s): Noboru Mizushima
  • Organizer: Keystone Symposium: Autophagy Network Integration in Health and Disease
  • Place of Presentation: Copper Mountain (USA)
  • Year and Date: 2017-02-12
  • Int'l Joint Research / Invited
• [Presentation] Autophagy in intracellular quality control (2017)
  • Author(s): Noboru Mizushima
  • Organizer: Keystone Symposia on Aging and Mechanisms of Aging-Related Disease
  • Int'l Joint Research / Invited
• [Presentation] Physiological roles and molecular mechanisms of autophagy (2017)
  • Author(s): Noboru Mizushima
  • Organizer: The 14th Bone Biology Forum
  • Int'l Joint Research
• [Presentation] Maturation of the autophagosome (2017)
  • Author(s): Noboru Mizushima
  • Organizer: EMBO Conference "Autophagy - from molecular principles to human diseases"
  • Int'l Joint Research / Invited
• [Presentation] Autophagosomal closure is mediated by the ESCRT machinery (2017)
  • Author(s): Keigo Morita, Ikuko Koyama-Honda, Yoshihiro Yamashita, Toshihide Ueno, Eiji Morita, Hiroyuki Mano, Noboru Mizushima
  • Organizer: The American Society of Cell Biology 57th Annual Meeting
  • Int'l Joint Research
• [Presentation] Autophagy research: recent progresses and future directions (2017)
  • Author(s): Noboru Mizushima
  • Organizer: The 42nd Annual Meeting of the Japan Society for Investigative Dermatology
  • Int'l Joint Research / Invited
• [Presentation] Identification of helical AIMs as a novel type of Atg8-interacting motif (2017)
  • Author(s): Akinori Yamasaki, Xiao-Man Liu, Li-Lin Du, Nobuo N. Noda
  • Organizer: The 8th International Symposium on Autophagy
  • Int'l Joint Research
• [Presentation] 脂質化に依存しないAtg8の機能および新規ヘリックス様Atg8結合モチーフの解析 (2017)
  • Author(s): 山崎章徳, Xiao-Man Liu, Li-Lin Du, 野田展生
  • Organizer: 2017年度生命科学系学会合同年次大会
• [Presentation] Live imaging and molecular dissection of organelle degradation in the lens (2016)
  • Author(s): Noboru Mizushima
  • Organizer: The XXII Biennial Meeting of the International Society for Eye Research
  • Place of Presentation: 京王プラザホテル（東京都・新宿区）
  • Year and Date: 2016-09-28
  • Int'l Joint Research / Invited
• [Presentation] Physiological functions and molecular mechanisms of autophagy (2016)
  • Author(s): Noboru Mizushima
  • Organizer: Tigem Seminar
  • Place of Presentation: Naples (Italy)
  • Year and Date: 2016-07-20
  • Int'l Joint Research / Invited
• [Presentation] The Life of the Autophagosome (2016)
  • Author(s): Noboru Mizushima
  • Organizer: Keystone Symposia Autophagy: Molecular and Physiological Mechanisms
  • Place of Presentation: Whistler (Canada)
  • Year and Date: 2016-06-06
  • Int'l Joint Research / Invited
• [Presentation] The ATG conjugation systems in malaria parasites (2016)
  • Author(s): Joe Kimanthi Mutungi, Mayurbhai Himatbhai Sahani, Noboru Mizushima
  • Organizer: Yonung Investigator Conference on Autophagy (A3)
  • Place of Presentation: 新潟大学（新潟県新潟市）
  • Year and Date: 2016-02-18
  • Int'l Joint Research
• [Remarks] 領域ホームページ
  • URL: http://www.proteolysis.jp/autophagy/
• [Remarks] 東京大学大学院医学系研究科分子生物学分野ホームページ
  • URL: http://square.umin.ac.jp/molbiol/
• [Remarks] 東京大学医学系研究科分子生物学分野ホームページ
  • URL: http://www.cellcycle.m.u-tokyo.ac.jp/
• [Funded Workshop] 第8回オートファジーに関する国際会議（ISA） (2017)