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「個性」創発脳システムの統合的理解を拓く国際的データシェアプラットフォームの構築

International

Project AreaIntegrative research toward elucidation of generative brain systems for individuality
Project/Area Number 16K21734
Research Category

Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

Allocation TypeMulti-year Fund
Review Section Complex systems
Research InstitutionTohoku University

Principal Investigator

大隅 典子  東北大学, 医学系研究科, 教授 (00220343)

Co-Investigator(Kenkyū-buntansha) 保前 文高  首都大学東京, 人文科学研究科, 准教授 (20533417)
若林 明雄  千葉大学, 大学院人文科学研究院, 教授 (30175062)
中島 欽一  九州大学, 医学研究院, 教授 (80302892)
星野 幹雄  国立研究開発法人国立精神・神経医療研究センター, 神経研究所 病態生化学研究部, 部長 (70301273)
今吉 格  京都大学, 生命科学研究科, 特定准教授 (60543296)
郷 康広  大学共同利用機関法人自然科学研究機構(新分野創成センター), 新分野創成センター, 特任准教授 (50377123)
冨永 貴志  徳島文理大学, 神経科学研究所, 准教授 (20344046)
駒木 文保  東京大学, 大学院情報理工学系研究科, 教授 (70242039)
柴田 智広  九州工業大学, 大学院生命体工学研究科, 教授 (40359873)
Project Period (FY) 2016-06-30 – 2021-03-31
Project Status Granted (Fiscal Year 2017)
Budget Amount *help
¥65,650,000 (Direct Cost: ¥50,500,000、Indirect Cost: ¥15,150,000)
Fiscal Year 2020: ¥13,130,000 (Direct Cost: ¥10,100,000、Indirect Cost: ¥3,030,000)
Fiscal Year 2019: ¥13,130,000 (Direct Cost: ¥10,100,000、Indirect Cost: ¥3,030,000)
Fiscal Year 2018: ¥13,130,000 (Direct Cost: ¥10,100,000、Indirect Cost: ¥3,030,000)
Fiscal Year 2017: ¥13,130,000 (Direct Cost: ¥10,100,000、Indirect Cost: ¥3,030,000)
Fiscal Year 2016: ¥13,130,000 (Direct Cost: ¥10,100,000、Indirect Cost: ¥3,030,000)
Keywords脳科学 / 基盤・社会脳科学 / 脳計測科学 / 個性 / 神経基盤
Outline of Annual Research Achievements

1. 研究者招聘・派遣:6/23日に連携先のAlbert Einstein医学校の 廣井昇教授を新分野創成センターに招聘した。9/7-9日の第60回日本神経化学大会において、領域支援によりエラスムス大学のY. Elgersma博士による特別講演を開催し続くシンポジウムにおいて「個性」の一つの現れと見なすこともできる発達障害の発症・病態メカニズムに関する情報交換を行った。同シンポジウムには建国大学のY.S. Chan博士、ベイラー医科大学のR.C.Samaco博士を招聘した。10/21-22日に開催された第9回光操作研究会@東北大学ににコロンビア大学のE. Hillman博士、フライブルグ大学のF. Schneider博士を招聘し最先端の神経科学ツールに関する講演を伺った。ConBio2017のシンポジウムにカロリンスカ研究所のC.B.Goncalo博士, Imperial College LondonのT. Knopfel博士を招聘した。12/2日の第13回成体脳のニューロン新生懇談会(九州大学)にUT SouthwesternのJ. Hsieh博士を招聘した。派遣では駒木班の松田孟留特任助教がA. Hyvarinen博士(Univ. College London)のもとに派遣され機械学習や画像処理に関するスキルの習得や関連分野研究者との意見交換を行った。今吉班の鈴木裕輔特任助教を共同研究先のD. Eilam教授(テルアビブ大学)の元に派遣した。2. 国際シンポジウム:2018年7月に京都大学にて領域会議に引き続き開催することを決定し、今吉が世話人として会場準備等に当たっている。3. データシェアリングプラットフォーム構築:柴田(A03)が分担研究者の理化学研究所バイオリソースセンターの桝屋とともにマウス行動解析の国際的なデータシェアリング構築について情報交換を行った。

Current Status of Research Progress
Current Status of Research Progress

2: Research has progressed on the whole more than it was originally planned.

Reason

1. 研究者招聘・派遣:2018年度における若手海外派遣として、8月末に東北大学の吉川貴子助教を米国コロンビア大学に、駒木班の松田孟留特任助教をUniversity College London(英国)に、今吉班の山田真弓特任助教と他1名を国立台湾大学(NTU)に派遣が予定されている。若林班では7月にA.Neubauer博士(University of Graz)とE. Jauk博士(Dresden Tech Univ.)を千葉大学に招聘し共同研究を加速させる。2. 国際シンポジウム:2018年7月24~25日に京都大学において領域会議に引き続き開催する国際シンポジウムの海外講演者について招聘の準備を進めている。その他の学会シンポジウム等における外国人招聘者についても、予算執行状況に合わせ随時進める予定である。3. データシェアリングプラットフォーム構築:柴田が分担研究者である理化学研究所バイオリソースセンターの桝屋とともに、マウス行動解析の国際的なデータシェアリング構築について進めている。

Strategy for Future Research Activity

1. 研究者招聘・派遣:2018年9月~10月に、マレーシアの医学研究所よりElda Nurafnie Ibnu Rasid研究官を東北大学に受入れ、大隅研において哺乳類全胚培養技術の習得について指導する予定である。2018年度後半には、翌2019年度の若手派遣・外国人研究者招聘の募集を行う。2018年度後半の国内開催学会において、国際支援班参画研究者がオーガナイズするシンポジウムに外国人研究者を招聘し、領域内研究者との共同研究等についての打合せを行う。2. 国際シンポジウム:2018年7月24~25日に開催する国際シンポジウムにおいて、海外よりAljoscha Neubauer博士(University of Graz)、大石健一博士(Johns Hopkins Medicine)、Thomas Bourgeron博士(Paster Institute)、David Eilam博士(Tel-Aviv University)、Kate L.Laskowski博士(Leibniz-Institute)、Erich D. Jarvis博士(The Rockefeller University)、Ryan Remedios博士(California Institute of Technology)らを招聘し、「個性」の科学的研究についての国際的な推進を図る。3. データシェアリングプラットフォーム構築:2018年4月末に行う第1回USVミーティングの折に、柴田、菅野、大隅によりデータシェアリング構築の進め方についての詳細を打合せる。

Report

(2 results)
  • 2017 Research-status Report
  • 2016 Research-status Report

Research Products

(74 results)

All 2018 2017 2016 Other

All Journal Article Presentation Remarks

  • [Journal Article] Explicit Performance in Girls and Implicit Processing in Boys: A Simultaneous fNIRS?ERP Study on Second Language Syntactic Learning in Young Adolescents2018

    • Author(s)
      Sugiura L, Hata M, Matsuba Kurita H, Uga M, Tsuzuki D, Dan I, Hagiwara H and Homae
    • Journal Title

      Frontiers in Human Neuroscience

      Volume: 12 Pages: 1-12

    • DOI
      10.3389/fnhum.2018.00062
    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Therapeutic time window of anti-high mobility group box-1 antibody administration in mouse model of spinal cord injury2018

    • Author(s)
      Nakashima H, Tsujimura K, Irie K, Ishizu M, Pan M, Kameda T, Nakashima K:
    • Journal Title

      Neuroscience Research

      Volume: -

    • DOI
      10.1016/j.neures.2018.03.004
    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Ectopic neurogenesis induced by prenatal antiepileptic drug exposure augments seizure susceptibility in adult mice2018

    • Author(s)
      Sakai A, Matsuda T, Doi H, Nagaishi Y, Kato K, Nakashima K
    • Journal Title

      Proc Natl Acad Sci USA

      Volume: - Pages: 4270-4275

    • DOI
      10.1073/pnas.1716479115
    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Prior Treatment with Anti-High Mobility Group Box-1 Antibody Boosts Human Neural Stem Cell Transplantation-Mediated Functional Recovery After Spinal Cord Injury2018

    • Author(s)
      Uezono N, Zhu Y, Y, Matsuda T,Nakajo M, Abematsu M, Setoguchi T, Mori S, Takahashi HK, Komiya S, Nishibori M, Nakashima K:
    • Journal Title

      Stem Cells.

      Volume: - Pages: 0-0

    • DOI
      10.1002/stem.2802
    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] HMGB2 expression is associated with transition from a quiescent to an activated state of adult neural stem cells2018

    • Author(s)
      Kimura A, Matsuda T, Sakai A, Murao N, Nakashima K
    • Journal Title

      Dev Dyn

      Volume: 247

    • DOI
      10.1002/dvdy.24559
    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Neural stem cell therapy aiming at better functional recovery after spinal cord injury.2018

    • Author(s)
      Zhu Y, Uezono N, Yasui T, Nakashima K
    • Journal Title

      Dev Dyn

      Volume: 247

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Meis1 coordinates cerebellar granule cell development by regulating Pax6 transcription, BMP signaling and Atoh1 degradation.2018

    • Author(s)
      Owa Tomoo、Taya Shinichiro、Miyashita Satoshi、Yamashita Mariko、Adachi Toma、Yamada Koyo、Yokoyama Miwa、Aida Shogo、Nishioka Tomoki、Inoue Yukiko U.、Goitsuka Ryo、Nakamura Takuro、Inoue Takayoshi、Kaibuchi Kozo、Hoshino Mikio
    • Journal Title

      J Neurosci.

      Volume: 38 Pages: 1277-1294

    • DOI
      10.1523/jneurosci.1545-17.2017
    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Generation of Pax6-IRES-EGFP knock-in mouse via the cloning-free CRISPR/Cas9 system to reliably visualize neurodevelopmental dynamics.2018

    • Author(s)
      Inoue Yukiko U.、Morimoto Yuki、Hoshino Mikio、Inoue Takayoshi
    • Journal Title

      Neuroscience Research

      Volume: in press

    • DOI
      10.1016/j.neures.2018.01.007
    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Entrainment of the Circadian Clock in Neural Stem Cells by Epidermal Growth Factor is Closely Associated with ERK1/2-mediated Induction of Multiple Clock-related Genes.2018

    • Author(s)
      Mogi A, Yomoda R, Kimura S, Tsushima C, Takouda J, Sawauchi M, Maekawa T, Ohta H, Nishino S, Kurita M, Mano N, Osumi N, Moriya T
    • Journal Title

      Neuroscience

      Volume: 379 Pages: 45-66

    • DOI
      10.1016/j.neuroscience.2018.02.045
    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] The role of Pax6 in brain development and its impact on pathogenesis of autism spectrum disorder.2018

    • Author(s)
      Kikkawa Takako、Casingal Cristine R.、Chun Seung Hee、Shinohara Hiroshi、Hiraoka Kotaro、Osumi Noriko
    • Journal Title

      Brain Res

      Volume: - Pages: 30111-2

    • DOI
      10.1016/j.brainres.2018.02.041
    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Adult-born neurons facilitate olfactory bulb pattern separation during task engagement2018

    • Author(s)
      Li W, Chu MW, Wu A, Suzuki Y, Imayoshi I and Komiyama T
    • Journal Title

      eLife

      Volume: 7

    • DOI
      10.7554/elife.33006
    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] The effects of actual situations and the facial expressions of another person when experiencing pain on observers' understanding of the pain and sense of unpleasantness2017

    • Author(s)
      河村康佑、若林明雄
    • Journal Title

      NINCHISHINRIGAKUKENKYU

      Volume: 15 Issue: 1 Pages: 13-19

    • DOI
      10.5265/jcogpsy.15.13
    • NAID
      130006251026
    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Synergistic induction of astrocytic differentiation by factors secreted from meninges in the mouse developing brain2017

    • Author(s)
      Kawamura Y, Katada S, Noguchi H, Yamamoto H, Sanosaka T, Iihara K, Nakashima K
    • Journal Title

      FEBS Letters

      Volume: 59 Pages: 3709-3720

    • DOI
      10.1002/1873-3468.12881
    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] DNA methylome analysis identifies transcription factor-based epigenomic signatures of multilineage competence in neural stem/progenitor cells.2017

    • Author(s)
      Sanosaka T, Imamura T, Hamazaki N, Chai M, Igarashi K, Ideta-Otsuka M, Miura F, Ito T, Fujii N, Ikeo K, Nakashima K.
    • Journal Title

      Cell Reports

      Volume: 20 Pages: 2992-2992

    • DOI
      10.1016/j.celrep.2017.08.086
    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] NEUROD1 instructs neuronal conversion in non-reactive astrocytes2017

    • Author(s)
      Brulet R, Matsuda T, Zhang L, Miranda C, Giacca M, Kaspar BK, Nakashima K, Hsieh J
    • Journal Title

      Stem Cell Reports

      Volume: 8 Pages: 1506-1515

    • DOI
      10.1016/j.stemcr.2017.04.013
    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Emerging mechanisms underlying astrogenesis in the developing mammalian brain2017

    • Author(s)
      Takouda J, Katada S, Nakashima K
    • Journal Title

      Proc. Jpn. Acad., Ser. B

      Volume: 93 Issue: 6 Pages: 386-398

    • DOI
      10.2183/pjab.93.024
    • NAID
      130005696812
    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Hypoxia Epigenetically Confers Astrocytic Differentiation Potential on Human Pluripotent Cell-Derived Neural Precursor Cells2017

    • Author(s)
      Yasui T, Uezono N, Nakashima H Noguchi H, Matsuda T, Noda-Andoh T, Okano H, Nakashima K:
    • Journal Title

      Stem Cell Reports

      Volume: 8 Pages: 1743-1756

    • DOI
      10.1016/j.stemcr.2017.05.001
    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Dynamics of the cell division orientation of granule cell precursors during cerebellar development2017

    • Author(s)
      Miyashita S, Adachi T, Yamashita M, Sota T, Hoshino M:
    • Journal Title

      Mech Dev

      Volume: 147 Pages: 1-7

    • DOI
      10.1016/j.mod.2017.06.002
    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Pathologic Active mTOR Mutation in Brain Malformation with Intractable Epilepsy Leads to Cell-Autonomous Migration Delay2017

    • Author(s)
      Hanai S, Sukigara S, Dai H, Owa T, Horike SI, Otsuki T, Saito T, Nakagawa E, Ikegaya N, Kaido T, Sato N, Takahashi A, Sugai K, Saito Y, Sasaki M, Hoshino M, Goto YI, Koizumi S, Itoh M
    • Journal Title

      Am J Pathol

      Volume: 187 Pages: 1177-1185

    • DOI
      10.1016/j.ajpath.2017.01.015
    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Neuronal Migration and AUTS2 Syndrome.2017

    • Author(s)
      Kei Hori、Mikio Hoshino
    • Journal Title

      Brain Sci

      Volume: 7 Pages: 54-54

    • DOI
      10.3390/brainsci7050054
    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Organizing activity of Fgf8 on the anterior telencephalon2017

    • Author(s)
      Sato T, Kikkawa T, Saito T, Itoi K, Osumi N
    • Journal Title

      Development Growth and Differentiation

      Volume: 59 Pages: 701-712

    • DOI
      10.1111/dgd.12411
    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Early postnatal vocalizations predict sociability and spatial memory in C57BL/6J mice: Individual differences in behavioral traits emerge early in development.2017

    • Author(s)
      Yoshizaki Kaichi, Koike Kohei, Kimura Ryuichi, Osumi Noriko
    • Journal Title

      PLoS ONE

      Volume: -

    • DOI
      10.1371/journal.pone.0186798
    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Direct estimation of de novo mutation rates in a chimpanzee parent-offspring trio by ultra-deep whole genome sequencing2017

    • Author(s)
      Tatsumoto S, Go Y, Fukuta K, Noguchi H, Hayakawa T, Tomonaga M, Hirai H, Matsuzawa T, Agata K, Fujiyama A
    • Journal Title

      Scientific Reports

      Volume: 7 Pages: 13561-13561

    • DOI
      10.1038/s41598-017-13919-7
    • NAID
      120006358802
    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] The Effects of International Trade on Water Use2017

    • Author(s)
      Kagohashi, K., T. Tsurumi, and S. Managi.
    • Journal Title

      PLoS One.

      Volume: 10(1) Issue: 7 Pages: 1-11

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Firing rate estimation using infinite mixture models and its application to neural decoding2017

    • Author(s)
      Shibue R, Komaki F:
    • Journal Title

      Journal of Neurophysiology

      Volume: 118 Pages: 2902-2913

    • DOI
      10.1152/jn.00818.2016
    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Multivariate time series decomposition into oscillation components2017

    • Author(s)
      Matsuda T, Komaki F:
    • Journal Title

      Neural Computation

      Volume: 29 Pages: 2055-2075

    • DOI
      10.1162/neco_a_00981
    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Electroporation in the rodent embryonic brain using whole embryo culture system.2017

    • Author(s)
      Kikkawa T, Takahashi M, Osumi N
    • Journal Title

      Current Protocols in Neuroscience

      Volume: 78 Pages: 1-16

    • DOI
      10.1002/cpns.21
    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] NeuroD1 instructs neuronal conversion 1 in non-reactive astrocytes2017

    • Author(s)
      Brulet R, Matsuda T, Zhang L, Miranda C, Giacca M, Kaspar BK, Nakashima K Hsieh J.
    • Journal Title

      Stem Cell Rep.

      Volume: 印刷中

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Manipulation of promoter-associated noncoding RNAs in mouse early embryos for controlling sequence-specific epigenetic status2017

    • Author(s)
      Hamazaki N, Nakashima K, Imamura T.
    • Journal Title

      Methods in Molecular Biology

      Volume: 1543 Pages: 271-271

    • DOI
      10.1007/978-1-4939-6716-2_16
    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] A point process modeling approach for investigating the effect of online brainactivity on perceptual switching2017

    • Author(s)
      Matsuda, T., Kitajo, K., Yamaguchi, Y., and Komaki, F.
    • Journal Title

      NeuroImage

      Volume: 152 Pages: 50-59

    • DOI
      10.1016/j.neuroimage.2017.02.068
    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Time series decomposition into oscillation components and phase estimation2017

    • Author(s)
      Matsuda, T. and Komaki, F.
    • Journal Title

      Neural Computation

      Volume: 29 Pages: 332-367

    • DOI
      10.1162/neco_a_00916
    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Individual Differences and the Effect of Face Configuration Contexts in the McGurk Effect2017

    • Author(s)
      Ujiie, Y., Asai, Y., Wakabayashi, A.
    • Journal Title

      Experimental Brain Research

      Volume: 印刷中

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Paternal aging affects behaviors in Pax6 mutant mice: a gene/environmental interaction in understanding neurodevelopmental disorders.2016

    • Author(s)
      Yoshizaki K, Furuse, T, Kimura R, Tucci V, Kaneda H, Wakana S and Osumi N
    • Journal Title

      PLoS ONE.

      Volume: 11

    • DOI
      10.1371/journal.pone.0166665
    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Mechanisms of DHA transport to the brain and potential therapy to neurodegenerative diseases2016

    • Author(s)
      Lo Van A, Sakayori N, Hachem M, Belkouch M, Picq M, Lagarde M, Osumi N, Bernoud-Hubac N.
    • Journal Title

      Biochimie.

      Volume: 130 Pages: 163-167

    • DOI
      10.1016/j.biochi.2016.07.011
    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Maternal Nutritional Imbalance between Linoleic Acid and Alpha-Linolenic Acid Increases Offspring’s Anxious Behavior with a Sex-Dependent Manner in Mice2016

    • Author(s)
      Sakayori, N., Tokuda, H., Yoshizaki, K., Kawashima, H., Innis, SM., Shibata, H. and Osumi, N
    • Journal Title

      The Tohoku Journal of Experimental Medicine

      Volume: 240 Issue: 1 Pages: 31-37

    • DOI
      10.1620/tjem.240.31
    • NAID
      130005406204
    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Single-neuron and genetic correlates of autistic behavior in macaque.2016

    • Author(s)
      K. Yoshida, Y. Go, I. Kushima, A. Toyoda, A. Fujiyama, H. Imai, N. Saito, A. Iriki, N. Ozaki, M. Isoda
    • Journal Title

      Sci Adv

      Volume: 2

    • DOI
      10.1126/sciadv.1600558
    • NAID
      120006222007
    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Identification of Protein Kinase Substrates by the Kinase-Interacting Substrate Screening (KISS) Approach.2016

    • Author(s)
      Amano, M., Nishioka, T., Yura, Y., and Kaibuchi, K.
    • Journal Title

      Curr Protoc Cell Biol.

      Volume: 72 Pages: 1-12

    • DOI
      10.1002/cpcb.8
    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Brain enhancer activities at the gene-poor 5p14.1 autism-associated locus2016

    • Author(s)
      Inoue YU, Inoue T
    • Journal Title

      Scientific Reports

      Volume: 9 Pages: 31227-31227

    • DOI
      10.1038/srep31227
    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] Analysis of Autism Susceptibility Candidate 2 (AUTS2) gene during development2018

    • Author(s)
      Hoshino M, Hori K
    • Organizer
      第8回 新潟大学脳研究所共同研究拠点国際シンポジウム
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] The role of AUTS2 in synaptic formation and the cognitive brain functions2018

    • Author(s)
      Hori K, Nagai T, Shan W, Yamada M, Shiraishi R, Sakamoto A, Kanno K, Abe M, Yamada K, Sakimura K, Hoshino M
    • Organizer
      第8回新潟大学脳研究所共同研究拠点国際シンポジウム
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Visualization and humanization of oxytocin receptor expressions in mice; towards the clinical application of oxytocin to autism spectrum disorders2018

    • Author(s)
      Inoue YU, Morimoto Y, Inoue T
    • Organizer
      第9回 武田科学振興財団薬科学シンポジウム Genome Editing Towards Medicinal Applications
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Insights into Rett Syndrome using Neural Stem Cells,2017

    • Author(s)
      Nakashima K.
    • Organizer
      Keystone Symposium
    • Place of Presentation
      Olympic Valley, USA
    • Year and Date
      2017-01-08
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Pre-existing reduced functional connectivity between cognitive control network and salience network enhances PTSD symptoms after a disaster: evidence from a longitudinal2017

    • Author(s)
      Sekiguchi A, Kotozaki Y, Sugiura M, Nakagawa S, Nouchi R, Miyauchi CM, Takeuchi H, Taki Y, Kawashima R
    • Organizer
      Society for Neuroscience 2017
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Uniqueness of the gaze cue in spatial anisotropy of visual attention.2017

    • Author(s)
      Eito H, Wakabayashi A
    • Organizer
      Fechner Day 2017 The 33rd Annual meeting
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] DNA methylomes identifiy transcription factor-based epigenomic signatures for timed acquisition of differentiation competence in neural stem/progenitor cells towards neuronal and glia lineages2017

    • Author(s)
      今村拓也、佐野坂司、浜崎伸彦、Chai Muh Chyi、五十嵐勝秀、大塚まき、三浦史仁、伊藤隆司、藤井信之、池尾一穂、中島欽一
    • Organizer
      4th World Congress of Reproductive Biology
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Hypoxia epigenetically confers astrocytic differentiation potential on human pluripotent cell-derived neural precursor cells2017

    • Author(s)
      中島 欽一
    • Organizer
      The 72nd Fujihara Seminar Molecular Mechanism of Molding and Disruption of the Epigenomes Underlying Cellular Community
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Regulation of non-coding RNA contributes to the complete cessation of cell proliferation of neuron-like cells2017

    • Author(s)
      今村拓也、山本直樹、阿形清和、中島欽一
    • Organizer
      第43回内藤コンファレンス
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Neurogenesis: Specification of Cerebellar Progenitors2017

    • Author(s)
      Hoshino M
    • Organizer
      the 8th International Symposium of The Society for Research on the Cerebellum and Ataxia
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Generation of Pax6-IRES-EGFP knock-in mouse via cloning-free CRISPR/Cas9 system for neurodevelopmental researches2017

    • Author(s)
      Inoue YU, Hoshino M, Inoue T
    • Organizer
      Society for Neuroscience 2017
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Paternal aging-induced differential DNA methylation in sperm: possible effects on gene expression and behavior in offspring2017

    • Author(s)
      Osumi N, Kimura R, Yoshizaki K, Koike T, Oki S, Mochizuki K, Kikkawa T, Inada H, Matsui Y, Kono T
    • Organizer
      Society for Neuroscience 2017
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Paternal aging model of autism: a possible epigenetic mechanism2017

    • Author(s)
      Osumi N
    • Organizer
      Albert Einstein College of Medicine 廣井研究室セミナー
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Trans-generational transmission of ASD-like phenotypes possibly via sperm epigenetic alteration caused by paternal age2017

    • Author(s)
      Kimura R, Yoshizaki K, Koike T, Oki S, Aoki N, Mochizuki K, Kobayashi H, Kikkawa T, Inada H, Matsui Y, Kono T, Osumi N
    • Organizer
      国際自閉症カンファレンス東京2017
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Paternal aging affects offspring's behavior possibly via an epigenetic mechanism involving a transcriptional repressor REST2017

    • Author(s)
      Osumi N
    • Organizer
      Link_ping University-JSPS Meeting
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Voltage-sensitive dye imaging study of the input-dependent GABAergic control of the paired burst facilitation (PBF) in area CA1 of the hippocampus2017

    • Author(s)
      Tominaga T and Tominaga Y
    • Organizer
      Society for Neuroscience
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Voltage-sesitive dye signal analysis of inhibitory components in mouse perirhinal-entorrhinal cortical slices2017

    • Author(s)
      Wakayama Y, Kamada S, Yamada Y, Tominaga T, Kajiwara R
    • Organizer
      Society for Neuroscience
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Information Geometry of predictive densities and its application to Poisson regression2017

    • Author(s)
      Komaki F
    • Organizer
      Lilac International Conference of Application on Statistics (LICAS 2017)
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Shrinkage Priors for Poisson-Based Models and Their Applications2017

    • Author(s)
      Komaki F
    • Organizer
      Joint Statistical Meetings 2017(JSM2017)
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Neural decoding based on an infinite mixture model2017

    • Author(s)
      Shibue R and Komaki F
    • Organizer
      The 1st International Conference on Econometrics and Statistics (EcoSta 2017)
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] A predictive approach to statistical problems with multiplicity2017

    • Author(s)
      Komaki F
    • Organizer
      CMStatistics 2017
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] The hippocampal beta rhythm and the computational model of it2017

    • Author(s)
      Kageyama I, Natsume K
    • Organizer
      NOLTA2017 Special Sessions
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] A Novel Practical Approach to Prosthetic Control of Continuous Multi-Fingered Kinematics with a Low-Cost Wearable sEMG Device2017

    • Author(s)
      Shibata T, Shibata T
    • Organizer
      39th Annual International Conference of the IEEE Engineering in Medicine and Biology Society
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] A Study on Automatic OWAS Classification of the Working Postures of a Caregiver2017

    • Author(s)
      Omure Y, Izumi H, Shibata T
    • Organizer
      39th Annual International Conference of the IEEE Engineering in Medicine and Biology Society
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Spatiotemporal brain transcriptome architecture in the common marmoset2016

    • Author(s)
      Go Y.
    • Organizer
      The 6th annual conference of Japan Society for Marmoset Research, Brain/MINDS international symposium
    • Place of Presentation
      東京(東京大学弥生講堂)
    • Year and Date
      2016-12-14
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Shrinkage priors for a class of Poisson regression models2016

    • Author(s)
      Komaki F.
    • Organizer
      Computational and Methodological Statistics (CMStatistics 2016)
    • Place of Presentation
      Seville, Spain
    • Year and Date
      2016-12-10
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Role of Meis1 in the cerebellar development2016

    • Author(s)
      Owa T, Taya S, Miyashita S, Nishioka T, Kaibuchi K, Hoshino M:
    • Organizer
      Neuroscience2016
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2016-11-14
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Network plasticity facilitating the neural excitation propagation between the perirhinal and entorhinal cortices as revealed by voltage-sensitive dye imaging2016

    • Author(s)
      R. Kajiwara, Y. Wakayama, Y. Tominaga, T. Tominaga
    • Organizer
      Neuroscience 2016
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2016-11-14
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Activation of GABAA-receptors by high-frequency stimuli causes paired burst facilitations in area CA1 of the hippocampal slice2016

    • Author(s)
      Tominaga T and Tominaga Y.
    • Organizer
      Neuroscience 2016
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2016-11-14
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] aternal aging-induced differential DNA methylation in sperm: possible transgenerational effects on gene expression and behavior in offspring,2016

    • Author(s)
      Kimura R., Yoshizaki K., Koike T., Koike K., Kikkawa T., Inada H., Matsui Y., Kono T. and Osumi N.
    • Organizer
      Neuroscience 2016
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2016-11-13
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] The characteristics of the cortical functional networks in individual infants2016

    • Author(s)
      Homae, F., Watanabe, H., & Taga, G.
    • Organizer
      The Society for Functional Near Infrared Spectroscopy 2016 Biennial Meeting
    • Place of Presentation
      Paris, France
    • Year and Date
      2016-10-16
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Spatiotemporal gene expression trajectory in the human and non-human ape brains2016

    • Author(s)
      Go Y.
    • Organizer
      The 6th Joint CIN-NIPS International Symposium
    • Place of Presentation
      Tubingen, Germany
    • Year and Date
      2016-10-11
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Paternal aging-induced differential DNA methylation in sperm: possible transgenerational effects on gene expression and behavior.2016

    • Author(s)
      Osumi N.
    • Organizer
      Genome Imprinting Epigenetics and Physiologizal Functions
    • Place of Presentation
      Erice, Italy
    • Year and Date
      2016-10-06
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Paternal aging affects offspring’s behavior: its significance and possible underlying transgenerational epigenetics.2016

    • Author(s)
      Osumi N.
    • Organizer
      The 19th KSBNS Annual Meeting
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      2016-09-28
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research / Invited
  • [Remarks] 多様な「個性」を創発する脳システムの統合的理解 【領域略称「個性」創発脳】

    • URL
      http://www.koseisouhatsu.jp/index.html
    • Related Report
      2017 Research-status Report
  • [Remarks] 平成28年度採択新学術領域 「個性」創発脳

    • URL
      http://www.koseisouhatsu.jp
    • Related Report
      2016 Research-status Report

URL: 

Published: 2016-07-04   Modified: 2018-12-17  

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