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Integrative understanding of biological phenomena with temperature as a key theme

Administrative Group

Project AreaIntegrative understanding of biological phenomena with temperature as a key theme
Project/Area Number 15H05927
Research Category

Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

Allocation TypeSingle-year Grants
Review Section Biological Sciences
Research InstitutionCenter for Novel Science Initatives, National Institutes of Natural Sciences (2018-2019)
Okazaki Research Facilities, National Institutes of Natural Sciences (2015-2017)

Principal Investigator

TOMINAGA Makoto  大学共同利用機関法人自然科学研究機構(新分野創成センター、アストロバイオロジーセンター、生命創成探究, 生命創成探究センター, 教授 (90260041)

Project Period (FY) 2015-06-29 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥71,500,000 (Direct Cost: ¥55,000,000、Indirect Cost: ¥16,500,000)
Fiscal Year 2019: ¥15,470,000 (Direct Cost: ¥11,900,000、Indirect Cost: ¥3,570,000)
Fiscal Year 2018: ¥15,600,000 (Direct Cost: ¥12,000,000、Indirect Cost: ¥3,600,000)
Fiscal Year 2017: ¥15,600,000 (Direct Cost: ¥12,000,000、Indirect Cost: ¥3,600,000)
Fiscal Year 2016: ¥15,600,000 (Direct Cost: ¥12,000,000、Indirect Cost: ¥3,600,000)
Fiscal Year 2015: ¥9,230,000 (Direct Cost: ¥7,100,000、Indirect Cost: ¥2,130,000)
Keywords温度生物学 / 生理学 / 神経科学
Outline of Final Research Achievements

This research project concerns two subgroups, ‘temperature sensing’ and ‘temperature-responding systems’, and sought to integrate our understanding of temperature-dependent biological phenomena with the development of techniques that detect and regulate local temperatures in cells and organs. In this project we clarified: 1) How temperature-sensing mechanisms in the plasma membrane and in cells work together to allow precise temperature detection; 2) How temperature is sensed and integrated in temperature-dependent physiological responses that include regulation of body temperature, metabolism, circadian clock and animal behavior; and 3) What are the mechanisms and physiological functions of spatiotemporal non-homogeneity of temperature distribution and detection. A general team organized directed research group activities to facilitate the fruitful collaboration and made effective outreach activities for the people who are normally not involved in science.

Academic Significance and Societal Importance of the Research Achievements

以下の目的を達成したことが学術的意義であり、その成果をHPや公開シンポジウム等の様々な方法で社会に発信し続けたことが社会的意義である。1)「温度センシング」では、細胞膜と細胞内の温度センシング機構が協働して、細胞が温度を感知し機能発現にいたるメカニズムを明らかにする。2)「温度応答システム」では、感知された温度情報が統合され、個体レベルでの体温・代謝調節、生体リズム調節、行動制御などの生理現象にいたる生体メカニズムを明らかにする。3) 温度分布と温度感知の空間的不均一性と時間的変動の発生機序と生理的役割を明らかにする。

Report

(6 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Annual Research Report
  • 2017 Annual Research Report
  • 2016 Annual Research Report
  • 2015 Annual Research Report
  • Research Products

    (6 results)

All 2019 2017 2016 Other

All Int'l Joint Research (1 results) Presentation (1 results) Remarks (2 results) Funded Workshop (2 results)

  • [Int'l Joint Research] フリンダース大学(オーストラリア)

    • Related Report
      2015 Annual Research Report
  • [Presentation] 温度感受性TRPチャネルの生理機能2016

    • Author(s)
      富永 真琴
    • Organizer
      第93回日本生理学会
    • Place of Presentation
      札幌コンベンションセンター(北海道・札幌市)
    • Year and Date
      2016-03-24
    • Related Report
      2015 Annual Research Report
  • [Remarks] 科学研究費補助金 新学術領域研究「温度生物学」ホームページ

    • URL

      https://www.nips.ac.jp/thermalbio/

    • Related Report
      2019 Annual Research Report
  • [Remarks] 科学研究費補助金 新学術領域研究「温度生物学」ホームページ

    • URL

      http://www.nips.ac.jp/thermalbio/

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report 2016 Annual Research Report 2015 Annual Research Report
  • [Funded Workshop] FAOPS2019(Federation of the Asian and Oceanian Physiological Societies) Whole day Symposium:Thermal biology2019

    • Related Report
      2018 Annual Research Report
  • [Funded Workshop] 2017年「温度生物学」公開国際シンポジウム2017

    • Related Report
      2017 Annual Research Report

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Published: 2015-07-02   Modified: 2022-11-04  

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