| Budget Amount *help |
¥68,380,000 (Direct Cost: ¥52,600,000、Indirect Cost: ¥15,780,000)
Fiscal Year 2019: ¥9,230,000 (Direct Cost: ¥7,100,000、Indirect Cost: ¥2,130,000)
Fiscal Year 2018: ¥13,910,000 (Direct Cost: ¥10,700,000、Indirect Cost: ¥3,210,000)
Fiscal Year 2017: ¥9,230,000 (Direct Cost: ¥7,100,000、Indirect Cost: ¥2,130,000)
Fiscal Year 2016: ¥13,910,000 (Direct Cost: ¥10,700,000、Indirect Cost: ¥3,210,000)
Fiscal Year 2015: ¥22,100,000 (Direct Cost: ¥17,000,000、Indirect Cost: ¥5,100,000)
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| Outline of Final Research Achievements |
In this study, we aimed to understand the mechanism of the harmony of chromosome functions (Chromosome Orchestration System: Chromosome OS) through the reconstruction of three-dimensional structure of chromosomes and the acquisition of four-dimensional information. The knowledge obtained in this area has been integrated into a chromosome OS information platform, compiled into a database, and made available to the public. It is expected to contribute to the further development of life science as a whole, not only in the fields of epigenetics and chromosome biology, but also in the fields of drug discovery, clinical practice, etc. Model chromosomes, which were constructed through biochemical efforts in this field, have also caused a stir in the current genomics-oriented chromosomal field, and have laid the groundwork for biochemical approaches to delving deeper into the conundrum of chromosome structure control.
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