Chromosome Orchestration System

• Project Area: Chromosome Orchestration System
• Project/Area Number: 15H05970
• Research Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: The University of Tokyo
• Principal Investigator: 白髭 克彦 東京大学, 定量生命科学研究所, 教授 (90273854)
• Co-Investigator(Kenkyū-buntansha): 伊藤 武彦 東京工業大学, 生命理工学研究科, 教授 (90501106)
• Project Period (FY): 2015-06-29 – 2020-03-31
• Project Status: Granted (Fiscal Year 2019)
• Budget Amount: ¥68,380,000 (Direct Cost: ¥52,600,000、Indirect Cost: ¥15,780,000); Fiscal Year 2019: ¥9,230,000 (Direct Cost: ¥7,100,000、Indirect Cost: ¥2,130,000); Fiscal Year 2018: ¥13,910,000 (Direct Cost: ¥10,700,000、Indirect Cost: ¥3,210,000); Fiscal Year 2017: ¥9,230,000 (Direct Cost: ¥7,100,000、Indirect Cost: ¥2,130,000); Fiscal Year 2016: ¥13,910,000 (Direct Cost: ¥10,700,000、Indirect Cost: ¥3,210,000); Fiscal Year 2015: ¥22,100,000 (Direct Cost: ¥17,000,000、Indirect Cost: ¥5,100,000)
• Keywords: ゲノム / 発現制御 / 生態生命情報学 / 染色体構造 / 染色体動態 / 染色体高次構造 / 染色体構築原理 / 生体生命情報学

Outline of Annual Research Achievements

班全体の活動としては、５/30-6/1の日程で国際班会議をストックホルムにて、また、班会議を1/28-29の日程で赤湯にて開催し、領域内での情報交換と研究の評価活性化の機会とした。また、11/12-11/16まで金沢にて3R-3C国際シンポジウムを、1/23-25は染色体ワークショップを宝塚にて共催し、多くの班員および、海外の第一線で活躍している研究者が参加した。6/21、3/26にはサイエンスカフェ、9/30、10/28にサイエンススクールを東京にて主催し、基礎研究および研究倫理等の科学を取り巻く問題の情報発信を行うと共に、遺伝子とは何か、モデル生物とは何かについて子供向けの講演会を行った。
領域内連携も活発であり、平野ー境によるコンデンシン動態のモデリング、広田ー伊藤によるキナーゼ動態の定量的モデル化、深川ー伊藤によるキネトコア高次構造の解析、鐘巻ー白髭によるコヒーシンアセチル化酵素の動態解析、高橋ー小布施による新しいミスマッチ修復機構の発見など枚挙にいとまがない。その他、西山の一分子観察系や平野の染色体再構成系を用いた多くの共同研究が現在も進行中であり、また論文としても発表されている。
領域の大きな目標であるモデル染色体の構築と染色体OS情報プラットフォームについては、前者については平野の染色体再構成系が組換型タンパクにて置き換えられた、より洗練されたものになりつつあり深川、白髭、岡田、広田、岩崎、らとの共同研究が進められている。後者については新たに班員データを登録し、充実化を図ったと共に、2017年度まで公募研究として加わっていた東大・中井グループが開発したOpen Looperデータベースとの連携強化を図り、ChIP-seq, Hi-Cなど他グループが研究した成果との対比を容易にできる機能面の充実を実施した。

Current Status of Research Progress

2: Research has progressed on the whole more than it was originally planned.

Reason

当初の計画通りに成果を上げつつ順調に進んでいる。
理由としては、連携研究や海外との共同研究が数多く進んでいることと、順調に研究成果が報告されていること、情報発信が順調になされていることが挙げられる。

Strategy for Future Research Activity

今年度は最終年度であるため、業績公開を推進すると共に、モデル染色体と染色体情報プラットフォームの公開に注力していく。最終年度の国際班会議、また、領域が共催する国際会議が二件計画されており（Gordon reserch conferenceとEMBO workshop）、これらの場を通じて、情報発信、学術交流を推進していきたい。

Research Products

• [Int'l Joint Research] Univ. Copenhagen(デンマーク)
• [Int'l Joint Research] オックスフォード大学/Crick研究所/エジンバラ大学(英国)
• [Int'l Joint Research] FMI(スイス)
• [Int'l Joint Research] EMBL(ドイツ)
• [Int'l Joint Research] カロリンスカ研究所(スウェーデン)
• [Int'l Joint Research]
• [Int'l Joint Research] クリック研究所/アバディーン大学/オックスフォード大学(イギリス)
• [Int'l Joint Research] ペンシルバニア大学(アメリカ合衆国)
• [Int'l Joint Research] カロリンスカ研究所(スウェーデン)
• [Int'l Joint Research] EMBL(ドイツ)
• [Int'l Joint Research] ニュージャージ医科大学/フィラデルフィア小児病院(アメリカ)
• [Int'l Joint Research] オックスフォード大学/アバディーン大学/The Francis Crick Institute(イギリス)
• [Int'l Joint Research] カロリンスカ研究所(スウェーデン)
• [Int'l Joint Research] Seoul National大学/Chung-Ang大学(韓国)
• [Int'l Joint Research] MFPL/IMP(オーストリア)
• [Int'l Joint Research]
• [Int'l Joint Research] ニュージャージー医科大学/フィラデルフィア小児病院(アメリカ)
• [Int'l Joint Research] オックスフォード大学/アバディーン大学/The Francis Crick Institute(イギリス)
• [Int'l Joint Research] Karolinska Institutet(スウェーデン)
• [Int'l Joint Research] Seoul National 大学/Chung-Ang 大学(韓国)
• [Int'l Joint Research] MFPL/IMPIMP(オーストリア)
• [Int'l Joint Research]
• [Journal Article] Pulmonary phagocyte-derived NPY controls the pathology of severe influenza virus infection (2019)
  • Author(s): Fujiwara S., Hoshizaki M., Ichida Y., Lex D., Kuroda E., Ishii KJ., Magi S., Okada M., Takao H., Gando M., Imai H., Hara R., Herzog H., Yoshimura A., Okamura H., Penninger JM., Slutsky AS., Uhlig S., Kuba K., and Imai Y.
  • Journal Title: Nat Microbiol. Volume: 4(2) Pages: 258-268
  • DOI: 10.1038/s41564-018-0289-1
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Human RAD51 paralogue, SWSAP1, fosters RAD51 filament by regulating the anti-recombinase, FIGNL1 AAA+ ATPase. (2019)
  • Author(s): Matsuzaki Kenichiro、Kondo Shizuka、Ishikawa Tatsuya、Shinohara Akira
  • Journal Title: Nature Communications Volume: 10 Pages: 1407-1407
  • DOI: 10.1038/s41467-019-09190-1
  • Peer Reviewed / Open Access
• [Journal Article] Platanus-allee is a de novo haplotype assembler enabling a comprehensive access to divergent heterozygous regions. (2019)
  • Author(s): Kajitani R, Yoshimura D, Okuno M, Minakuchi Y, Kagoshima H, Fujiyama A, Kubokawa K, Kohara Y, Toyoda A, Itoh T
  • Journal Title: Nature Communications Volume: - Issue: 1 Pages: 1702-1702
  • DOI: 10.1038/s41467-019-09575-2
  • Peer Reviewed / Open Access
• [Journal Article] A chromatin integration labelling method enables epigenomic profiling with lower input. (2019)
  • Author(s): Harada Akihito、Maehara Kazumitsu、Handa Tetsuya、Arimura Yasuhiro、Nogami Jumpei、Hayashi-Takanaka Yoko、Shirahige Katsuhiko、Kurumizaka Hitoshi、Kimura Hiroshi、Ohkawa Yasuyuki
  • Journal Title: Nat Cell Biol Volume: 21 Pages: 287-296
  • DOI: 10.1038/s41556-018-0248-3
  • Peer Reviewed / Open Access
• [Journal Article] Multiple phosphorylations control recruitment of the KMN network onto kinetochores (2018)
  • Author(s): Hara M, Ariyoshi M, Okumura EI, Hori T, Fukagawa T.
  • Journal Title: Nature Cell Biology Volume: 20 Pages: 1378-1388
  • DOI: 10.1038/s41556-018-0230-0
  • Peer Reviewed / Open Access
• [Journal Article] Nucleosomes around a mismatched base pair are excluded via an Msh2-dependent reaction with the aid of SNF2 family ATPase Smarcad1 (2018)
  • Author(s): Terui R, Nagao K, Kawasoe Y, Taki K, Higashi TL, Tanaka S, Nakagawa T, Obuse C, Masukata H, Takahashi TS
  • Journal Title: Genes & Development Volume: 32(11-12) Pages: 806-821
  • DOI: 10.1101/gad.310995.117
  • Peer Reviewed / Open Access
• [Journal Article] DNA polymerase ε-dependent modulation of the pausing property of the CMG helicase at the barrier (2018)
  • Author(s): Hizume, K., Endo, S., Muramatsu, S., Kobayashi, T. and Araki, H.
  • Journal Title: Genes & Development Volume: 32 Pages: 1315-1320
  • DOI: 10.1101/gad.317073.118
  • Peer Reviewed / Open Access
• [Journal Article] Re-evaluating the Localization of Sperm-Retained Histones Revealed the Modification-Dependent Accumulation in Specific Genome Regions (2018)
  • Author(s): Yamaguchi K, Hada M, Fukuda Y, Inoue E, Makino Y, Katou Y, Shirahige K, Okada Y.
  • Journal Title: Cell Reports Volume: 23(13) Pages: 3920-3932
  • DOI: 10.1016/j.celrep.2018.05.094
  • Peer Reviewed / Open Access
• [Journal Article] Temporal Regulation of ESCO2 Degradation by the MCM Complex, the CUL4-DDB1-VPRBP Complex, and the Anaphase-Promoting Complex (2018)
  • Author(s): Minamino M, Tei S, Negishi L, Kanemaki MT, Yoshimura A, Sutani T, Bando M, Shirahige K.
  • Journal Title: Current Biology Volume: 28(16) Pages: 2665-2672
  • DOI: 10.1016/j.cub.2018.06.037
  • Peer Reviewed / Open Access
• [Journal Article] Two three-strand intermediates are processed during Rad51-driven DNA strand exchange (2018)
  • Author(s): Ito K, Murayama Y, Takahashi M, Iwasaki H.
  • Journal Title: Nature Structural & Molecular Biology Volume: 25 Pages: 29-36
  • DOI: 10.1038/s41594-017-0002-8
  • Peer Reviewed
• [Journal Article] Mitotic chromosome assembly despite nucleosome depletion in Xenopus egg extracts (2017)
  • Author(s): Shintomi K, Inoue F, Watanabe H, Ohsumi K, Ohsugi M, Hirano T.
  • Journal Title: Science Volume: 356 Pages: 1284-1287
  • DOI: 10.1126/science.aam9702
  • Peer Reviewed
• [Journal Article] Association of M18BP1/KNL2 with CENP-A Nucleosome Is Essential for Centromere Formation in Non-mammalian Vertebrates. (2017)
  • Author(s): Hori T, Shang WH, Hara M, Ariyoshi M, Arimura Y, Fujita R, Kurumizaka H, Fukagawa T.
  • Journal Title: Dev Cell Volume: 42 Pages: 181-189
  • DOI: 10.1016/j.devcel.2017.06.019
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Pre‐initiation complex assembly functions as a molecular switch that splits the Mcm2‐7 double hexamer (2017)
  • Author(s): Miyazawa-Onami, M., Araki, H. and Tanaka, S
  • Journal Title: EMBO Rep. Volume: 18 Pages: 1752-1761
  • DOI: 10.15252/embr.201744206
  • Peer Reviewed
• [Journal Article] Decreased cohesin in the brain leads to defective synapse devclopmont and anxicty-related behavior. (2017)
  • Author(s): Fujita Y, Masuda K, Bando M, Nakato R, Katou Y, Tanaka T, Nakayama M, Takao K, Miyakawa T, Tanaka T, Ago Y, Hashimoto H, Shirahige K, Yamashita T
  • Journal Title: The Journal of Experiment Medicine Volume: 印刷中 Issue: 5 Pages: 1431-1452
  • DOI: 10.1084/jem.20161517
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Identification of a variant-specific phosphorylation of TH2A during spermiogenesis. (2017)
  • Author(s): Hada M, Masuda K, Yamaguchi K, Shirahige K, Okada Y.
  • Journal Title: Sci Rep. Volume: 7 Pages: 46228-46228
  • DOI: 10.1038/srep46228
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] ChIP-seq Analysis of Condensin Complex in Cultured Mammalian Cells. (2017)
  • Author(s): Sakata T, Shirahige K, Sutani T.
  • Journal Title: Methods Mol Biol. Volume: 1515 Pages: 257-271
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Recent advances in ChIP-seq analysis: from quality management to whole-genome annotation (2017)
  • Author(s): Nakato R, Shirahige K.
  • Journal Title: Briefings in Bioinformatics Volume: 12 Pages: 1-12
  • DOI: 10.1093/bib/bbw023
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Chromatin determinants of the inner-centromere rely on replication factors with functions that impart cohesion. (2016)
  • Author(s): Abe T, Kawasumi, R. Arakawa, H. Hori, T. Shirahige, K. Losada, A. Fukagawa, T. Branzei, D.
  • Journal Title: Oncotarget. Volume: 7 Pages: 67934-67947
  • DOI: 10.18632/oncotarget.11982
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Attaching Accessory Devices to the Replisome. (2016)
  • Author(s): Sutani T, Shirahige K.
  • Journal Title: Mol Cell. Volume: 63(3) Pages: 347-8
  • DOI: 10.1016/j.molcel.2016.07.017
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Physical Association of Saccharomyces cerevisiae Polo-like Kinase Cdc5 with Chromosomal Cohesin Facilitates DNA Damage Response. (2016)
  • Author(s): Pakchuen S, Ishibashi M, Takakusagi E, Shirahige K, Sutani T.
  • Journal Title: J Biol Chem. Volume: 291(33) Pages: 17228-46
  • DOI: 10.1074/jbc.m116.727438
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] DNMT3A R882 mutant interacts with polycomb proteins to block hematopoietic stem and leukemic cell differentiation. (2016)
  • Author(s): Koya J, Kataoka K, Sato T, Bando M, Kato Y, Tsuruta-Kishino T, Kobayashi H, Narukawa K, Miyoshi H, Shirahige K, Kurokawa M.
  • Journal Title: Nature Communications Volume: 7 Pages: 10924-10924
  • DOI: 10.1038/ncomms10924
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Microarray expression analysis of genes involved in innate immune memory in peritoneal macrophages. (2015)
  • Author(s): Yoshida K, Renard-Guillet C, Inoue K, Shirahige K, Okada-Hatakeyama M, Ishii S.
  • Journal Title: Genomics Data Volume: 7 Pages: 90-1
  • DOI: 10.1016/j.gdata.2015.11.028
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Condensin Relocalization from Centromeres to Chromosome Arms Promotes Top2 Recruitment during Anaphase. (2015)
  • Author(s): Leonard J, Sen N, Torres R, Sutani T, Jarmuz A, Shirahige K, Aragon L.
  • Journal Title: Cell Rep. Volume: 13(11) Pages: 2336-44
  • DOI: 10.1016/j.celrep.2015.11.041
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] The transcription factor ATF7 mediates lipopolysaccharide-induced epigenetic changes in macrophages involved in innate immunological memory (2015)
  • Author(s): Yoshida K, Maekawa T, Zhu Y, Renard-Guillet C, Ishibashi K,Chatton B, Inoue K, Uchiyama T, Yamada T, Ohno N, Shirahige K, Okada-Hatakeyama M, Ishii S.
  • Journal Title: Nat. Immunol. Volume: 16(10) Pages: 1034-1043
  • DOI: 10.1038/ni.3257
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Replication-Coupled PCNA Unloading by the Elg1 Complex Occurs Genome-wide and Requires Okazaki Fragment Ligation. (2015)
  • Author(s): Takashi Kubota, Yuki Katou, Ryuichiro Nakato, Katsuhiko Shirahige, Anne D. Donaldson
  • Journal Title: Cell Rep. Volume: 12 Pages: 774-787
  • DOI: 10.1016/j.celrep.2015.06.066
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Condensin targets and reduces unwound DNA structures associated with transcription in mitotic chromosome condensation. (2015)
  • Author(s): Takashi Sutani, Toyonori Sakata, Ryuichiro Nakato, Koji Masuda, Mai Ishibashi, Daisuke Yamashita, Yutaka Suzuki, Tatsuya Hirano, Masashige Bando, Katsuhiko Shirahige
  • Journal Title: Nat Commun Volume: 6 Pages: 10924-10924
  • DOI: 10.1038/ncomms8815
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] The Deubiquitinating Enzyme USP7 Regulates Androgen Receptor Activity by Modulating Its Binding to Chromatin. (2015)
  • Author(s): Shu-Ting Chen, Maiko Okada, Ryuichiro Nakato, Kosuke Izumi, Masashige Bando and Katsuhiko Shirahige
  • Journal Title: J Biol Chem. Volume: 290 Pages: 21713-21723
  • DOI: 10.1074/jbc.m114.628255
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Assembly of Slx4 signaling complexes behind DNA replication forks. (2015)
  • Author(s): Attila Balint, TaeHyung Kim, David Gallo, Jose Renato Cussiol, Francisco M Bastos de Oliveira, Askar Yimit, Jiongwen Ou, Ryuichiro Nakato, Alexey Gurevich, Katsuhiko Shirahige, Marcus B Smolka, Zhaolei Zhang, Grant W Brown
  • Journal Title: EMBO J. Volume: 34 Pages: 2182-2197
  • DOI: 10.15252/embj.201591190
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Esco1 acetylates cohesin via a mechanism different from that of Esco2 (2015)
  • Author(s): Masashi Minamino, Mai Ishibashi, Ryuichiro Nakato, Kazuhiro Akiyama, Hiroshi Tanaka, Yuki Kato, Lumi Negishi, Toru Hirota, Takashi Sutani, Masashige Bando, Katsuhiko Shirahige
  • Journal Title: Curr Biol Volume: 25 Pages: 1694-1706
  • DOI: 10.1016/j.cub.2015.05.017
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Presentation] Formation, progression and stalling of bidirectional replication forks in budding yeast (2018)
  • Author(s): Araki, H
  • Organizer: EMBO/EMBL symposium: DNA replication: From basic biology to disease
  • Int'l Joint Research / Invited
• [Presentation] Rapid protein depletion in human cells by the auxin-inducible degron (AID) technology (2018)
  • Author(s): Kanemaki M
  • Organizer: Hong Kong University
  • Invited
• [Presentation] Centromere Dynamics During Mitotic progression (2018)
  • Author(s): Fukagawa T
  • Organizer: Gordon Research Conference on Centromere Biology
  • Int'l Joint Research / Invited
• [Presentation] Assembling mitotic chromosomes in vitro (2018)
  • Author(s): Hirano T
  • Organizer: The 11th 3R&3C Symposium
  • Int'l Joint Research / Invited
• [Presentation] De novo establishment and epigenetic maintenance of centromere chromatin on alpha-satellite DNA (2018)
  • Author(s): Masumoto H
  • Organizer: The 2018 "Centromere Biology" Gordon Research Conference
  • Int'l Joint Research / Invited
• [Presentation] Meiotic prophase pathway of cleavage-independent removal of cohesin from chromosomes during late prophase I (2018)
  • Author(s): Shinohara A
  • Organizer: Gordon Research Conference on Meiosis
  • Int'l Joint Research
• [Presentation] Regulation of Transcription by Cohesin and its loader (2018)
  • Author(s): Shirahige K
  • Organizer: Principles of Chromosome Structure and Function
  • Int'l Joint Research
• [Presentation] Transcriptional regulation by cohesin and its loader (2017)
  • Author(s): katsuhiko Shirahige
  • Organizer: 第9回NAGOYAグローバルリトリート
  • Place of Presentation: 愛知健康プラザ、愛知県大府市
  • Year and Date: 2017-02-10
  • Int'l Joint Research / Invited
• [Presentation] Condensin-based chromosome organization (2017)
  • Author(s): Tatsuya Hirano
  • Organizer: Keystone Symposium on “Genomic Instability and DNA Repair/DNA Replication and Recombination”
  • Int'l Joint Research / Invited
• [Presentation] Condensin-based chromosome organization (2017)
  • Author(s): Tatsuya Hirano
  • Organizer: Gordon Research Conference “Chromosome Dynamics”
  • Int'l Joint Research / Invited
• [Presentation] Control of Rad51/Dmc1 assembly by Rad51 mediators (2017)
  • Author(s): Akira Shinohara
  • Organizer: FASEB meeting on recombination & genome rearrangement,
  • Int'l Joint Research / Invited
• [Presentation] Analysis of human chromosome organization mediated by cohesin complex (2017)
  • Author(s): Toyonori Sakata, Katsuhiko Shirahige
  • Organizer: Genetic Networks (GN) Workshop
  • Int'l Joint Research / Invited
• [Presentation] Organization of 3D genome structure mediated by cohesin and CTCF (2017)
  • Author(s): Toyonori Sakata, Katsuhiko Shirahige
  • Organizer: EMBO Workshop “Evolution in the Time of Genome Architecture”
  • Int'l Joint Research / Invited
• [Presentation] DNA 複製の過去・現在・未来 - ゲノム複製からエピゲノム複製へ (2016)
  • Author(s): 白髭克彦
  • Organizer: 岡崎フラグメント50周年シンポジウム
  • Place of Presentation: 名古屋大学、愛知県名古屋市
  • Year and Date: 2016-12-21
  • Invited
• [Presentation] Transcriptional regulation by cohesin and its loader (2016)
  • Author(s): katsuhiko Shirahige
  • Organizer: CdLS symposium
  • Place of Presentation: アメリカ、フロリダ
  • Year and Date: 2016-09-06
  • Int'l Joint Research / Invited
• [Presentation] How cohesin and its loader regulate transcription? Clues from newly identi ed disease andin vitro reconstitution system (2016)
  • Author(s): katsuhiko Shirahige
  • Organizer: トロント大学のセミナー
  • Place of Presentation: カナダ、トロント
  • Invited
• [Presentation] 希少疾患と癌、その共通の分子病態から学ぶ転写伸長因子コヒーシンの役割 (2016)
  • Author(s): 白髭克彦
  • Organizer: 愛知県がんセンター セミナー
  • Place of Presentation: 愛知県がんセンター、愛知県名古屋市
  • Invited
• [Presentation] Transcriptional regulation by Cohesin and its loader (2015)
  • Author(s): Katsuhiko Shirahige
  • Organizer: International conference of the Korean Society for molecular and cellular biology
  • Place of Presentation: Soul、Korea
  • Year and Date: 2015-09-22
  • Int'l Joint Research / Invited
• [Presentation] The crude Lysate system to analyze transcriptional regulation by cohesin loader (2015)
  • Author(s): Katsuhiko Shirahige
  • Organizer: CSH Mechanisms of Eukaryotic Transcription
  • Place of Presentation: NY, USA
  • Year and Date: 2015-08-25
  • Int'l Joint Research
• [Remarks] 東大、遺伝情報を次の世代に正確に伝える仕組みを発見
  • URL: https://www.nikkei.com/article/DGXLRSP487269_X00C18A8000000/
• [Remarks] 遺伝子の入れ替えをコントロールするメカニズムを解明－ゲノム編集や不妊治療への応用に期待ー
  • URL: http://www.protein.osaka-u.ac.jp/achievement/pressrelease190404
• [Remarks] 定説を覆す！染色体の分配のしくみに、鍵となる新たな分子の働きを発見
  • URL: https://resou.osaka-u.ac.jp/ja/research/2018/20181113_1
• [Remarks] 相同組換えのDNA鎖交換反応開始の分子機構を解明 Swi5-Sfr1によるRad51のDNA結合制御
  • URL: https://www.titech.ac.jp/news/2018/042607.html
• [Remarks] 邪魔者をどかせると見えてきた、精子ヒストンの局在と規則性；新技術で精子ヒストンマップを作成
  • URL: http://www.iam.u-tokyo.ac.jp/press_release/180627-2/
• [Remarks] 平野・大杉班がScience誌に論文を発表しました
  • URL: http://www.chromosomeos.com/news/577
• [Remarks] 染色体オーケストレーションシステム
  • URL: http://www.chromosomeos.com/
• [Patent(Industrial Property Rights)] 遺伝性乳癌卵巣癌症候群の治療薬のスクリーニング方法 (2018)
  • Inventor(s): 岩﨑博史、坪内英生、伊藤武彦，梶谷嶺，リハッティマルダン、韓龍雲
  • Industrial Property Rights Holder: 東京工業大学
  • Industrial Property Rights Type: 特許
  • Filing Date: 2018
• [Patent(Industrial Property Rights)] 微生物由来カルボキシペプチダーゼの高血圧改善、心不全改善、急性呼吸窮迫症候群改善作用 (2018)
  • Inventor(s): 今井由美子
  • Industrial Property Rights Holder: 今井由美子
  • Industrial Property Rights Type: 特許
  • Filing Date: 2018
• [Patent(Industrial Property Rights)] 神経ペプチドNPYとその受容体の抗インフルエンザ作用 (2018)
  • Inventor(s): 今井由美子
  • Industrial Property Rights Holder: 今井由美子
  • Industrial Property Rights Type: 特許
  • Filing Date: 2018
• [Patent(Industrial Property Rights)] 遺伝性乳癌卵巣癌症候群の治療薬のスクリーニング方法 (2017)
  • Inventor(s): 岩崎博史,伊藤武彦
  • Industrial Property Rights Holder: 岩崎博史,伊藤武彦
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2018-077857
  • Filing Date: 2017
• [Funded Workshop] 染色体ワークショップ (2019)
• [Funded Workshop] 3R-3C国際シンポジウム (2018)
• [Funded Workshop] ストックホルム国際班会議 (2018)
• [Funded Workshop] The 4th Meeting on GRANT-IN-AID FOR SCIENTIFIC RESEARCH ON INNOVATIVE AREAS “CHROMOSOME ORCHESTRATION SYSTEM (CHROMOSOME OS)” (2017)
  • Place of Presentation: イギリス、ロンドン
  • Year and Date: 2017-02-20
• [Funded Workshop] the 2nd meeting on SMC proteins (2017)
• [Funded Workshop] The 10th 3R Symposium (2016)
  • Place of Presentation: ホテル一畑、島根県松江市
  • Year and Date: 2016-11-13
• [Funded Workshop] International Symposium on “Chromosome Orchestration System” (2016)
  • Place of Presentation: 淡路夢舞台国際会議場(兵庫県淡路市)
  • Year and Date: 2016-03-01