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Integrative understanding of biological signaling networks based on mathematical science

Administrative Group

Project AreaIntegrative understanding of biological signaling networks based on mathematical science
Project/Area Number 16H06573
Research Category

Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

Allocation TypeSingle-year Grants
Review Section Complex systems
Research InstitutionThe University of Tokyo

Principal Investigator

Takekawa Mutsuhiro  東京大学, 医科学研究所, 教授 (30322332)

Co-Investigator(Kenkyū-buntansha) 鈴木 貴  大阪大学, 数理・データ科学教育研究センター, 特任教授(常勤) (40114516)
井上 純一郎  東京大学, 医科学研究所, 特任研究員 (70176428)
Project Period (FY) 2016-06-30 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥27,820,000 (Direct Cost: ¥21,400,000、Indirect Cost: ¥6,420,000)
Fiscal Year 2020: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2019: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2018: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2017: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2016: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Keywordsシグナル伝達 / 数理科学 / 分子生物学 / プロテオミクス / ケミカルバイオロジー / 構造生物学 / 病態医科学 / 情報科学 / オミクス解析 / タンパク質 / システムズバイオロジー / 応用数学 / プロテオーム / オミクス / シミュレーション / 生体分子 / 数理解析 / 細胞内シグナル伝達 / 生命情報学 / 数理生物学
Outline of Final Research Achievements

In this project, we have elucidated the basic principles underlying the regulation of intracellular signaling networks and the resulting biological outcomes, and their failure in human diseases, through interdisciplinary collaborations between mathematical scientists and biomedical researchers. Our group also aimed to develop novel mathematical theories to accurately predict biological responses, critical biomarkers, and therapeutic targets for human diseases. To facilitate such interdisciplinary collaborations, we have held the steering committee meetings, annual meetings, domestic and international symposia, young researchers workshops and poster sessions, and other meetings. We have also released the web site and news letters to disclose information.

Academic Significance and Societal Importance of the Research Achievements

本領域研究では、数理科学研究者と生命科学研究者の異分野連携により、未知のシグナル伝達制御機構とその破綻がもたらす疾患発症機構を解明すると共に、疾患の克服に向けた応用研究へ発展させる事を目標に研究を進めた。また、生体応答を予測し、生命機能制御や疾患治療の鍵となる重要な分子や経路を抽出する新たな技術・理論の確立も目指した。その結果、新規シグナル伝達制御機構を多数同定する事に成功すると共に、生体応答の作動原理を抽出し、その理解を深化させる新たな基盤技術や理論を創出する事が出来た。また癌、感染症、神経変性疾患などに対する新規診断/治療法開発に繋がる成果が得られ、その一部は臨床試験にまで発展した。

Report

(6 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Annual Research Report
  • 2018 Annual Research Report
  • 2017 Annual Research Report
  • 2016 Annual Research Report
  • Research Products

    (174 results)

All 2021 2020 2019 2018 2017 2016 Other

All Int'l Joint Research (16 results) Journal Article (26 results) (of which Int'l Joint Research: 6 results,  Peer Reviewed: 25 results,  Open Access: 16 results,  Acknowledgement Compliant: 2 results) Presentation (127 results) (of which Int'l Joint Research: 21 results,  Invited: 32 results) Remarks (4 results) Funded Workshop (1 results)

  • [Int'l Joint Research] German Cancer Research Center(ドイツ)

    • Related Report
      2020 Annual Research Report
  • [Int'l Joint Research] Johns Hopkins School of Medicine/MD Anderson Cancer Center/Vanderbilt University(米国)

    • Related Report
      2020 Annual Research Report
  • [Int'l Joint Research] セントアンドリューズ大学(英国)

    • Related Report
      2020 Annual Research Report
  • [Int'l Joint Research] INRIAボルドー南西研究センター(フランス)

    • Related Report
      2020 Annual Research Report
  • [Int'l Joint Research] German Cancer Research Center(ドイツ)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] Johns Hopkins School of Medicine/MD Anderson Cancer Center/Vanderbilt University(米国)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] セントアンドリューズ大学(英国)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] INRIAボルドー南西研究センター(フランス)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] German Cancer Research Center(ドイツ)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] Johns Hopkins School of Medicine/MD Anderson Cancer Center/Vanderbilt University(米国)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] セントアンドリューズ大学(英国)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] INRIAボルドー南西研究センター(フランス)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] University Clinic Munster(Germany)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] MD Anderson Cancer Center/NCI, NIH/Johns Hopkins University(米国)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] National Cancer Institute, NIH/Johns Hopkins University(米国)

    • Related Report
      2016 Annual Research Report
  • [Int'l Joint Research] Jawaharlal Nehru University,(インド)

    • Related Report
      2016 Annual Research Report
  • [Journal Article] Stress-responsive MTK1 SAPKKK serves as a redox sensor that mediates delayed and sustained activation of SAPKs by oxidative stress2020

    • Author(s)
      Matsushita Moe、Nakamura Takanori、Moriizumi Hisashi、Miki Hiroaki、Takekawa Mutsuhiro
    • Journal Title

      Science Advances

      Volume: 6 Issue: 26 Pages: 1-1

    • DOI

      10.1126/sciadv.aay9778

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Prohibitin-1 Contributes to Cell-to-Cell Transmission of Herpes Simplex Virus 1 via the MAPK/ERK Signaling Pathway2020

    • Author(s)
      Watanabe Mizuki、Arii Jun、Takeshima Kosuke、Fukui Ayano、Shimojima Masayuki、Kozuka-Hata Hiroko、Oyama Masaaki、Minamitani Takeharu、Yasui Teruhito、Kubota Yuji、Takekawa Mutsuhiro、Kosugi Isao、Maruzuru Yuhei、Koyanagi Naoto、Kato Akihisa、Mori Yasuko、Kawaguchi Yasushi
    • Journal Title

      Journal of Virology

      Volume: 95 Issue: 3

    • DOI

      10.1128/jvi.01413-20

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Small Molecule Inhibitors of Middle East Respiratory Syndrome Coronavirus Fusion by Targeting Cavities on Heptad Repeat Trimers2020

    • Author(s)
      Kandeel Mahmoud、Yamamoto Mizuki、Al-Taher Abdulla、Watanabe Aya、Oh-hashi Kentaro、Park Byoung Kwon、Kwon Hyung-Joo、Inoue Jun-ichiro、Al-Nazawi Mohammed
    • Journal Title

      Biomolecules & Therapeutics

      Volume: Online first Issue: 4 Pages: 311-319

    • DOI

      10.4062/biomolther.2019.202

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Structural analysis of TIFA: Insight into TIFA-dependent signal transduction in innate immunity2020

    • Author(s)
      Nakamura Teruya、Hashikawa Chie、Okabe Kohtaro、Yokote Yuya、Chirifu Mami、Toma-Fukai Sachiko、Nakamura Narushi、Matsuo Mihoko、Kamikariya Miho、Okamoto Yoshinari、Gohda Jin、Akiyama Taishin、Semba Kentaro、Ikemizu Shinji、Otsuka Masami、Inoue Jun-ichiro、Yamagata Yuriko
    • Journal Title

      Scientific Reports

      Volume: 10 Issue: 1 Pages: 5152-5152

    • DOI

      10.1038/s41598-020-61972-6

    • Related Report
      2020 Annual Research Report 2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] System-Wide Analysis of Protein Acetylation and Ubiquitination Reveals a Diversified Regulation in Human Cancer Cells2020

    • Author(s)
      Kozuka-Hata Hiroko、Kitamura Aya、Hiroki Tomoko、Aizawa Aiko、Tsumoto Kouhei、Inoue Jun-ichiro、Oyama Masaaki
    • Journal Title

      Biomolecules

      Volume: 10 Issue: 3 Pages: 411-411

    • DOI

      10.3390/biom10030411

    • Related Report
      2020 Annual Research Report 2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] TIFAB Regulates USP15-Mediated p53 Signaling during Stressed and Malignant Hematopoiesis2020

    • Author(s)
      Niederkorn Madeline、Hueneman Kathleen、Choi Kwangmin、Varney Melinda E.、Romano Laurel、Pujato Mario A.、Greis Kenneth D.、Inoue Jun-ichiro、Meetei Ruhikanta、Starczynowski Daniel T.
    • Journal Title

      Cell Reports

      Volume: 30 Issue: 8 Pages: 2776-2790.e6

    • DOI

      10.1016/j.celrep.2020.01.093

    • Related Report
      2020 Annual Research Report 2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] EXOSC9 depletion attenuates P-body formation, stress resistance, and tumorigenicity of cancer cells.2020

    • Author(s)
      Yoshino S, Matsui Y, Fukui Y, Seki M, Yamaguchi K, Kanamori A, Saitoh Y, Shimamura T, Suzuki Y, Furukawa Y, Kaneko S, Seiki M, Murakami Y, Inoue JI, Sakamoto T.
    • Journal Title

      Sci Rep

      Volume: 10 Issue: 1 Pages: 9275-9275

    • DOI

      10.1038/s41598-020-66455-2

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The Anticoagulant Nafamostat Potently Inhibits SARS-CoV-2 S Protein-Mediated Fusion in a Cell Fusion Assay System and Viral Infection In Vitro in a Cell-Type-Dependent Manner2020

    • Author(s)
      Yamamoto Mizuki、Kiso Maki、Sakai-Tagawa Yuko、Iwatsuki-Horimoto Kiyoko、Imai Masaki、Takeda Makoto、Kinoshita Noriko、Ohmagari Norio、Gohda Jin、Semba Kentaro、Matsuda Zene、Kawaguchi Yasushi、Kawaoka Yoshihiro、Inoue Jun-ichiro
    • Journal Title

      Viruses

      Volume: 12 Issue: 6 Pages: 629-629

    • DOI

      10.3390/v12060629

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Stress-responsive MTK1 SAPKKK serves as a redox sensor that mediates delayed and sustained activation of SAPKs by oxidative stress.2020

    • Author(s)
      Matsushita M, Nakamura T, Moriizumi H, Miki H, and Takekawa M.
    • Journal Title

      Science Advances

      Volume: in press

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] MCRIP1 promotes the expression of lung-surfactant proteins in mice by disrupting CtBP-mediated epigenetic gene silencing2019

    • Author(s)
      Weng Jane S.、Nakamura Takanori、Moriizumi Hisashi、Takano Hiroshi、Yao Ryoji、Takekawa Mutsuhiro
    • Journal Title

      Communications Biology

      Volume: 2 Issue: 1 Pages: 227-227

    • DOI

      10.1038/s42003-019-0478-3

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] O-GlcNAc化蛋白質の検出と定量的解析を可能にするレクチン親和性ゲル電気泳動法の開発と応用.2019

    • Author(s)
      久保田裕二、藤岡興、武川睦寛
    • Journal Title

      生物物理化学-電気泳動-

      Volume: 63 Pages: 41-45

    • NAID

      130007669321

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Impact of spaceflight on the murine thymus and mitigation by exposure to artificial gravity during spaceflight2019

    • Author(s)
      Horie Kenta、Kato Tamotsu、Kudo Takashi、Sasanuma Hiroki、Miyauchi Maki、Akiyama Nobuko、Miyao Takahisa、Seki Takao、Ishikawa Tatsuya、Takakura Yuki、Shirakawa Masaki、Shiba Dai、Hamada Michito、Jeon Hyojung、Yoshida Nobuaki、Inoue Jun-ichiro、Muratani Masafumi、Takahashi Satoru、Ohno Hiroshi、Akiyama Taishin
    • Journal Title

      Scientific Reports

      Volume: 9 Issue: 1 Pages: 19866-19866

    • DOI

      10.1038/s41598-019-56432-9

    • NAID

      120007132915

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] TRAF6 maintains mammary stem cells and promotes pregnancy-induced mammary epithelial cell expansion2019

    • Author(s)
      Yamamoto Mizuki、Abe Chiho、Wakinaga Sakura、Sakane Kota、Yumiketa Yo、Taguchi Yuu、Matsumura Takayuki、Ishikawa Kosuke、Fujimoto Jiro、Semba Kentaro、Miyauchi Maki、Akiyama Taishin、Inoue Jun-ichiro
    • Journal Title

      Communications Biology

      Volume: 2 Issue: 1 Pages: 292-292

    • DOI

      10.1038/s42003-019-0547-7

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Minimum structural requirements for inhibitors of the zinc finger protein TRAF62019

    • Author(s)
      Radwan Mohamed O.、Koga Ryoko、Hida Tomohiro、Ejima Tomohiko、Kanemaru Yosuke、Tateishi Hiroshi、Okamoto Yoshinari、Inoue Jun-ichiro、Fujita Mikako、Otsuka Masami
    • Journal Title

      Bioorganic & Medicinal Chemistry Letters

      Volume: 29 Issue: 16 Pages: 2162-2167

    • DOI

      10.1016/j.bmcl.2019.06.050

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] O-GlcNAc化蛋白質の検出と定量的解析を可能にするレクチン親和性ゲル電気泳動法の開発と応用2019

    • Author(s)
      久保田 裕二、藤岡 興、武川 睦寛
    • Journal Title

      生物物理化学

      Volume: in press

    • NAID

      130007669321

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Critical roles of IκBα and RelA phosphorylation in transitional oscillation in NF-κB signaling module2019

    • Author(s)
      Hatanaka Naoya、Seki Takao、Inoue Jun-ichiro、Tero Atsushi、Suzuki Takashi
    • Journal Title

      Journal of Theoretical Biology

      Volume: 462 Pages: 479-489

    • DOI

      10.1016/j.jtbi.2018.11.023

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Wheat Germ Agglutinin (WGA)-SDS-PAGE: A Novel Method for the Detection of O-GlcNAc-modified Proteins by Lectin Affinity Gel Electrophoresis2018

    • Author(s)
      Fujioka Ko、Kubota Yuji、Takekawa Mutsuhiro
    • Journal Title

      BIO-PROTOCOL

      Volume: 8 Issue: 23

    • DOI

      10.21769/bioprotoc.3098

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A guanine derivative as a new MEK inhibitor produced by Streptomyces sp. MK63-43F2.2018

    • Author(s)
      M. Iijima, Yuji Kubota, R. Sawa, Yumiko Kubota, M. Hatano, M. Igarashi, M. Kawada, I. Momose, M. Takekawa, M. Shibasaki.
    • Journal Title

      J. Antibiot.

      Volume: 71 Issue: 1 Pages: 135-138

    • DOI

      10.1038/ja.2017.100

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Downregulation of dual-specificity phosphatase 4 enhances cell proliferation and invasiveness in colorectal carcinomas2017

    • Author(s)
      Ichimanda Michihiro、Hijiya Naoki、Tsukamoto Yoshiyuki、Uchida Tomohisa、Nakada Chisato、Akagi Tomonori、Etoh Tsuyoshi、Iha Hidekatsu、Inomata Masafumi、Takekawa Mutsuhiro、Moriyama Masatsugu
    • Journal Title

      Cancer Sci

      Volume: 109 Issue: 1 Pages: 250-258

    • DOI

      10.1111/cas.13444

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] WGA-based lectin affinity gel electrophoresis: A novel method for the detection of O-GlcNAc-modified proteins2017

    • Author(s)
      Kubota Yuji、Fujioka Ko、Takekawa Mutsuhiro
    • Journal Title

      PLOS ONE

      Volume: 12 Issue: 7 Pages: e0180714-e0180714

    • DOI

      10.1371/journal.pone.0180714

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] TIA1 oxidation inhibits stress granule assembly and sensitizes cells to stress-induced apoptosis.2016

    • Author(s)
      Arimoto-Matsuzaki K, Saito H and Takekawa M.
    • Journal Title

      Nature Commun.

      Volume: 7 Issue: 1

    • DOI

      10.1038/ncomms10252

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Genomic loss of DUSP4 contributes to the progression of intraepithelial neoplasm of pancreas to invasive carcinoma.2016

    • Author(s)
      Hijiya N, Tsukamoto Y, Nakada C, Tung NL, Kai T, Matsuura K, Shibata K, Inomata M, Uchida T, Tokunaga A, Amada K, Shirao K, Yamada Y, Mori H, Takeuchi I, Seto M, Aoki M, Takekawa M, Moriyama M.
    • Journal Title

      Cancer Res.

      Volume: 76 Issue: 9 Pages: 2612-2625

    • DOI

      10.1158/0008-5472.can-15-1846

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] A Phos-tag SDS-PAGE method that effectively uses phosphoproteomic data for profiling the phosphorylation dynamics of MEK1.2016

    • Author(s)
      Kinoshita E, Kinoshita-Kikuta E, Kubota Y, Takekawa M and Koike T.
    • Journal Title

      Proteomics

      Volume: 16 Issue: 13 Pages: 1825-1836

    • DOI

      10.1002/pmic.201500494

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Detection and functional analysis of SUMO-modified MEK.2016

    • Author(s)
      Kubota Y and Takekawa M.
    • Journal Title

      Methods in Molecular Biology

      Volume: 1487 Pages: 99-111

    • DOI

      10.1007/978-1-4939-6424-6_7

    • ISBN
      9781493964222, 9781493964246
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] MAPキナーゼ情報伝達経路の活性制御機構と疾患発症機構の解明2016

    • Author(s)
      武川睦寛
    • Journal Title

      生物物理化学 電気泳動

      Volume: 60 Pages: 7-10

    • NAID

      130005249511

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ストレス顆粒形成によるストレス誘導アポトーシスの制御と活性酸素によるその破綻2016

    • Author(s)
      武川睦寛
    • Journal Title

      生物物理化学 電気泳動

      Volume: 60

    • Related Report
      2016 Annual Research Report
  • [Presentation] Regulation of stress-induced apoptotic cell death by stress granule formation2021

    • Author(s)
      Mutsuhiro Takekawa
    • Organizer
      OIST seminar
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] Spatio-temporal dynamics of SAPKK regulates cell fate decisions under stress conditions2020

    • Author(s)
      Mutsuhiro Takekawa
    • Organizer
      JSPS Core-to-Core Program “Establishing International Research Network of Mathematical Oncology"
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Mathematical modeling of the recruitment of centriole biogenesis regulators to mother centrioles in the S-phase2020

    • Author(s)
      Nakamura T, Nishizumi-Tokai N, Nakazawa T, Mori T, Suzuki T, Takekawa M
    • Organizer
      JSPS Core-to-Core Program “Establishing International Research Network of Mathematical Oncology”
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] ERKシグナル誘導遺伝子による細胞機能制御と発癌2020

    • Author(s)
      武川睦寛
    • Organizer
      第93回日本生化学会大会シンポジウム
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] 新規酸化ストレスセンサー分子によるp38/JNKシグナルとサイトカイン産生の制御2020

    • Author(s)
      武川睦寛
    • Organizer
      MBSJ2020、第43回日本分子生物学会年会ワークショップ
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] 数理解析に基づくMAPKシグナルと生命機能制御機構の解明2020

    • Author(s)
      武川睦寛
    • Organizer
      令和2年度新学術領域研究数理シグナル領域推進会議
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] DNA損傷に応答するSAPKシグナル伝達機構の解析2020

    • Author(s)
      塩崎ゆかり、久保田裕二、武川睦寛
    • Organizer
      第79回日本癌学会学術総会
    • Related Report
      2020 Annual Research Report
  • [Presentation] カスパーゼ依存的蛋白質切断によるERKシグナル抑制機構2020

    • Author(s)
      久保田裕二、武川睦寛
    • Organizer
      第79回日本癌学会学術総会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 癌遺伝子によるストレス応答シグナル伝達経路の活性化機構の解析2020

    • Author(s)
      川瀧紗英子、久保田裕二、武川睦寛
    • Organizer
      第20回東京大学生命科学シンポジウム
    • Related Report
      2020 Annual Research Report
  • [Presentation] カスパーゼ依存的な蛋白質切断を介したERKシグナルの新規活性制御機構2020

    • Author(s)
      久保田裕二、武川睦寛
    • Organizer
      第71回日本電気泳動学会総会
    • Related Report
      2020 Annual Research Report
  • [Presentation] ERK経路の異常活性化により発現誘導される新規遺伝子の同定および機能解析2020

    • Author(s)
      高木祐輔、久保田裕二、武川睦寛
    • Organizer
      第71回日本電気泳動学会総会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 発癌シグナルによる p38/JNK 経路活性化の分子機構の解明2020

    • Author(s)
      川瀧紗英子、久保田裕二、武川睦寛
    • Organizer
      第71回日本電気泳動学会総会
    • Related Report
      2020 Annual Research Report
  • [Presentation] ストレス顆粒の新規構成因子およびその生理機能の解析2020

    • Author(s)
      吉岡 大介、中村 貴紀、武川 睦寛
    • Organizer
      第43回日本分子生物学会年会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Elucidation of the molecular mechanism underlying oncogene-induced activation of the p38 and JNK pathways2020

    • Author(s)
      Saeko Kawataki, Yuji Kubota, Mutsuhiro Takekawa
    • Organizer
      G2 plus Retreat
    • Related Report
      2020 Annual Research Report
  • [Presentation] Regulation of stress-activated p38/JNK MAPK signaling pathways under oxidative stress conditions.2019

    • Author(s)
      Mutsuhiro Takekawa
    • Organizer
      Cold Spring Harbor Asia Conference “Kinase and Phosphatase Signaling”
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Spatio-temporal regulation of stress-activated MAPK signaling and its role in cytokine production.2019

    • Author(s)
      Mutsuhiro Takekawa
    • Organizer
      Symposium for “Interface between Immunology & Quantitative Biology”
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 数理科学を活用したJNKシグナルと細胞運命制御機構の解明2019

    • Author(s)
      武川睦寛
    • Organizer
      第92回日本生化学会大会シンポジウム
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 新規ストレス・センサーによるストレス応答シグナルと炎症性サイトカイン産生の制御2019

    • Author(s)
      武川睦寛
    • Organizer
      第14回日本臨床ストレス応答学会シンポジウム
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] ストレス顆粒形成によるストレス誘導神経細胞死の制御と活性酸素によるその破綻2019

    • Author(s)
      武川睦寛
    • Organizer
      第38 回日本認知症学会学術集会シンポジウム
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] Regulation of stress-induced apoptotic cell death by stress granule formation2019

    • Author(s)
      Mutsuhiro Takekawa
    • Organizer
      第42回日本分子生物学会年会ワークショップ
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] レクチンアフィニティーゲル電気泳動法を利用したO-GlcNAc化タンパク質の解析2019

    • Author(s)
      久保田 裕二、武川 睦寛
    • Organizer
      日本プロテオーム学会2019年大会/第70日本電気泳動学会総会・合同大会シンポジウム
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 数理解析を活用した中心体複製開始を制御する分子機構の解明2019

    • Author(s)
      中村 貴紀、渡海 紀子、中澤 嵩、森 竜樹、鈴木 貴、武川 睦寛
    • Organizer
      第78回日本癌学会総会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 中心体複製初期に起こるPLK4の中心体輸送機構2019

    • Author(s)
      中村 貴紀、西住(渡海) 紀子、中澤 嵩、森 竜樹、鈴木 貴、武川 睦寛
    • Organizer
      第19回日本蛋白質科学年会・第71回日本細胞生物学会 合同年次大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] O-GlcNAc化蛋白質の網羅的探索技術の開発と細胞内シグナル伝達解析への応用2019

    • Author(s)
      久保田 裕二、武川 睦寛
    • Organizer
      新学術領域研究「数理シグナル」第3回若手ワークショップ
    • Related Report
      2019 Annual Research Report
  • [Presentation] ERK経路の異常活性化により発現誘導される新規遺伝子の同定および機能解析2019

    • Author(s)
      高木 祐輔、久保田 裕二、高橋 宏隆、澤崎 達也、武川 睦寛
    • Organizer
      新学術領域研究「数理シグナル」 第3回若手ワークショップ
    • Related Report
      2019 Annual Research Report
  • [Presentation] ストレス顆粒形成を制御する分子機構の解析2019

    • Author(s)
      橋本 夏葉、中村 貴紀、武川 睦寛
    • Organizer
      第42回日本分子生物学会年会
    • Related Report
      2019 Annual Research Report
  • [Presentation] ERK経路とストレス応答MAPK経路のクロストーク機構の解明2019

    • Author(s)
      川瀧 紗英子、久保田 裕二、武川 睦寛
    • Organizer
      第42回日本分子生物学会年会
    • Related Report
      2019 Annual Research Report
  • [Presentation] DNA損傷によるストレス応答MAPK経路活性化機構の解析2019

    • Author(s)
      塩崎 ゆかり、久保田 裕二、武川 睦寛
    • Organizer
      第42回日本分子生物学会年会
    • Related Report
      2019 Annual Research Report
  • [Presentation] ERK経路の異常活性化により発現誘導される新規遺伝子の同定および機能解析2019

    • Author(s)
      高木 祐輔、久保田 裕二、高橋 宏隆、澤崎 達也、武川 睦寛
    • Organizer
      第42回日本分子生物学会年会
    • Related Report
      2019 Annual Research Report
  • [Presentation] ストレス応答MAPキナーゼによるmiRNAの発現調節とアポトーシス誘導機構の解明2019

    • Author(s)
      渡海 紀子、中村 貴紀、武川 睦寛
    • Organizer
      第78回日本癌学会総会
    • Related Report
      2019 Annual Research Report
  • [Presentation] タンパク質O-GlcNAc化異常による増殖シグナルの活性化2019

    • Author(s)
      久保田 裕二、藤岡 興、武川 睦寛
    • Organizer
      第78回日本癌学会総会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Elucidation of the regulatory mechanism for transcription elongation by a novel ERK substrate2019

    • Author(s)
      大江 星菜、久保田 裕二、武川 睦寛
    • Organizer
      第92回日本生化学会大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Warburg効果による糖鎖修飾異常と癌増殖シグナルの活性化2019

    • Author(s)
      久保田 裕二、藤岡 興、武川 睦寛
    • Organizer
      第56回日本臨床分子医学会学術集会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Oncogenic activation of the ERK pathway alters the expression profiles of exosomal microRNAs in cancer cells2019

    • Author(s)
      Shiho Hirose, Yuji Kubota, Mutsuhiro Takekawa
    • Organizer
      第19回東京大学生命科学シンポジウム
    • Related Report
      2019 Annual Research Report
  • [Presentation] Mathematical analysis of the spatio-temporal regulation of the SAPK pathway2019

    • Author(s)
      森泉 寿士、中村 貴紀、曺 永旻、鈴木 貴、武川 睦寛
    • Organizer
      令和元年医科学研究所研究成果発表会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Elucidation of the regulatory mechanism for transcription elongation by a novel ERK substrate2019

    • Author(s)
      大江 星菜、久保田 裕二、武川 睦寛
    • Organizer
      令和元年医科学研究所研究成果発表会
    • Related Report
      2019 Annual Research Report
  • [Presentation] ERK経路の異常活性化により発現誘導される新規遺伝子の同定および機能解析2019

    • Author(s)
      高木 祐輔、久保田 裕二、武川 睦寛
    • Organizer
      新学術領域研究「数理シグナル」 領域推進会議
    • Related Report
      2019 Annual Research Report
  • [Presentation] Spatio-temporal dynamics of SAPKK regulates cell fate decisions under stress conditions.2019

    • Author(s)
      Takekawa M
    • Organizer
      OIST seminar
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Spatio-temporal regulation of JNK signaling during cell fate decisions.2019

    • Author(s)
      Takekawa M
    • Organizer
      1st International symposium on Interdisciplinary Approaches to Integrative Understanding of Biological Signaling Networks.
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Mathematical modeling of the recruitment of centriole biogenesis regulators to mother centrioles in centriole duplication phase.2019

    • Author(s)
      Nakamura T, Nishizumi-Tokai N, Nakazawa T, Mori T, Suzuki T and Takekawa M
    • Organizer
      Core-to-core meeting
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Mathematical analysis of the spatio-temporal regulation of SAPK pathway.2019

    • Author(s)
      Moriizumi H, Nakamura T, Youngmin C, Suzuki T and Takekawa M.
    • Organizer
      Core-to-core meeting
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Quantitative gene expression analysis in cells that express cancer- or congential Ras/MAPK syndrome-derived MEK mutants2019

    • Author(s)
      Kubota Y, Takagi Y and Takekawa M
    • Organizer
      1st International symposium on Interdisciplinary Approaches to Integrative Understanding of Biological Signaling Networks.
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] The molecular mechanism that recruits centriole biogenesis regulators to mother centrioles in centriole duplication phase.2019

    • Author(s)
      Nakamura T, Nishizumi-Tokai N, Nakazawa T, Mori T, Suzuki T and Takekawa M.
    • Organizer
      1st International symposium on Interdisciplinary Approaches to Integrative Understanding of Biological Signaling Networks.
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 数理解析を活用したSAPKシグナル時空間制御機構の解明2019

    • Author(s)
      森泉 寿士、中村 貴紀、曺 永旻、鈴木 貴、武川 睦寛
    • Organizer
      応用数理学会2019年研究部会連合発表会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Regulation of cell-fate decisions by stress-responsive p38/JNK MAPK signaling pathways2018

    • Author(s)
      Takekawa M.
    • Organizer
      OIST seminar
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 新規ストレス・センサーによるストレス応答MAPKシグナルとサイトカイン産生の制御2018

    • Author(s)
      武川 睦寛
    • Organizer
      第91回日本生化学会シンポジウム
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 数理解析を用いた中心体複製の開始制御機構の解明2018

    • Author(s)
      中村 貴紀、西住 紀子、中澤 嵩、森 竜樹、鈴木 貴、武川 睦寛
    • Organizer
      日本応用数理学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] O-GlcNAc化蛋白質の検出と定量解析を可能にするレクチン親和性ゲル電気泳動法の開発と応用2018

    • Author(s)
      久保田 裕二、藤岡 興、武川 睦寛
    • Organizer
      第69回日本電気泳動学会総会シンポジウム
    • Related Report
      2018 Annual Research Report
  • [Presentation] 数理解析を活用したSAPKシグナル時空間制御機構の解明2018

    • Author(s)
      森泉 寿士、中村 貴紀、曺 永旻、鈴木 貴、武川 睦寛
    • Organizer
      新学術領域「数理シグナル」第2回若手ワークショップ
    • Related Report
      2018 Annual Research Report
  • [Presentation] 数理解析を用いた中心体複製の開始制御機構の解明2018

    • Author(s)
      中村 貴紀、西住 紀子、中澤 嵩、森 竜樹、鈴木 貴、武川 睦寛
    • Organizer
      新学術領域「数理シグナル」第2回若手ワークショップ
    • Related Report
      2018 Annual Research Report
  • [Presentation] Identification of exosomal microRNAs induced by oncogenic activation of the ERK pathway2018

    • Author(s)
      Shiho Hirose、Yuji Kubota, Zhang Yao-zhong, Seiya Imoto, Mutsuhiro Takekawa
    • Organizer
      G2 plusリトリート
    • Related Report
      2018 Annual Research Report
  • [Presentation] Formation of stress granules suppresses apoptosis by sequestering proapoptotic proteins2018

    • Author(s)
      Daichi Fujikawa、Takanori Nakamura, Mutsuhiro Takekawa
    • Organizer
      G2 plusリトリート
    • Related Report
      2018 Annual Research Report
  • [Presentation] Oncogenic activation of the ERK pathway alters miRNA expression profiles in exosomes2018

    • Author(s)
      Shiho Hirose, Yuji Kubota, Zhang Yao-zhong, Seiya Imoto, Mutsuhiro Takekawa
    • Organizer
      東京大学医科学研究所 研究成果発表会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Formation of stress granules suppresses apoptosis by sequestering proapoptotic proteins2018

    • Author(s)
      Daichi Fujikawa, Takanori Nakamura, Mutsuhiro Takekawa
    • Organizer
      東京大学医科学研究所 研究成果発表会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 数理解析を活用したSAPKシグナル時空間制御機構の解明2018

    • Author(s)
      森泉 寿士、中村 貴紀、武川 睦寛
    • Organizer
      第18回東京大学 生命科学シンポジウム
    • Related Report
      2018 Annual Research Report
  • [Presentation] O-GlcNAc化蛋白質の検出と定量解析を可能にするレクチン親和性ゲル電気泳動法の開発と応用2018

    • Author(s)
      久保田 裕二、藤岡 興、武川 睦寛
    • Organizer
      第91回日本生化学会大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] ストレス応答MAPキナーゼp38, JNKによるアポトーシス関連miRNAの発現抑制2018

    • Author(s)
      渡海 紀子、中村 貴紀、武川 睦寛
    • Organizer
      第77回日本癌学会学術総会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 癌および先天性Ras/MAPK症候群で見出されるMEK突然変異体の解析2018

    • Author(s)
      久保田 裕二、高木 祐輔、松原 大祐、Ashwini Patil、木下 英司、中井 謙太、武川 睦寛
    • Organizer
      第77回日本癌学会学術総会
    • Related Report
      2018 Annual Research Report
  • [Presentation] ERK経路の異常活性化により発現誘導される遺伝子の同定と機能解析2018

    • Author(s)
      高木 祐輔、久保田 裕二、武川 睦寛
    • Organizer
      第77回日本癌学会学術総会
    • Related Report
      2018 Annual Research Report
  • [Presentation] ERK経路の異常活性化に伴いエクソソームに蓄積するmiRNAの解析、および早期がん診断マーカーへの応用2018

    • Author(s)
      広瀬 思帆、久保田 裕二、武川 睦寛
    • Organizer
      第77回日本癌学会学術総会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 数理解析を活用したSAPKシグナル時空間制御機構の解明2018

    • Author(s)
      森泉 寿士、中村 貴紀、曺 永旻、鈴木 貴、武川 睦寛
    • Organizer
      第41回日本分子生物学会年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] ERK新規基質分子による転写伸長反応制御機構の解明2018

    • Author(s)
      大江 星菜、久保田 裕二、武川 睦寛
    • Organizer
      第41回日本分子生物学会年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] ERK経路の異常活性化により発現が亢進する新規遺伝子の同定と機能解析2018

    • Author(s)
      高木 祐輔、久保田 裕二、高橋 宏隆、澤崎 達也、武川 睦寛
    • Organizer
      第41回日本分子生物学会年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] ストレス応答MAPキナーゼによるアポトーシス抑制性miRNAの発現制御2018

    • Author(s)
      渡海 紀子、中村 貴紀、武川 睦寛
    • Organizer
      第41回日本分子生物学会年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 数理解析を駆使した中心体複製開始を制御する分子機構の解明2018

    • Author(s)
      中村 貴紀、西住 紀子、中澤 嵩、森 竜樹、鈴木 貴、武川 睦寛
    • Organizer
      第41回日本分子生物学会年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] ストレス顆粒形成によるアポトーシス抑制機構の解明2018

    • Author(s)
      藤川 大地、中村 貴紀、武川 睦寛
    • Organizer
      第41回日本分子生物学会年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] ERK経路の活性化依存的にエクソソームに蓄積する癌関連miRNAの網羅的探索2018

    • Author(s)
      広瀬 思帆、久保田 裕二、武川 睦寛
    • Organizer
      第41回日本分子生物学会年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 炎症性サイトカインによるMTK1活性化機構の解析2018

    • Author(s)
      小森 満美子、久保田 裕二、武川 睦寛
    • Organizer
      第41回日本分子生物学会年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] ストレス顆粒を構成する新規因子の同定とその機能解析2018

    • Author(s)
      田口 真梨、中村 貴紀、武川 睦寛
    • Organizer
      第41回日本分子生物学会年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] ERK経路の異常活性化により誘発される新規癌増殖シグナル機構の解明2018

    • Author(s)
      久保田 裕二、武川 睦寛
    • Organizer
      第41回日本分子生物学会年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 数理解析を活用した中心体複製制御機構の解明2018

    • Author(s)
      武川睦寛
    • Organizer
      第1回MMDS/IMSUT/CBM合同ワークショップ
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] ERKシグナルによる癌抑制遺伝子のエピゲノム・サイレンシングと発がん2018

    • Author(s)
      武川睦寛
    • Organizer
      東京生化学研究会2017年度研究報告会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 癌抑制遺伝子MKK4のフィードバック・リン酸化の機能解析2018

    • Author(s)
      森泉寿士, 中村貴紀, 武川睦寛
    • Organizer
      第1回MMDS、医科学研究所、新領域創成科学研究科合同ワークショップ
    • Related Report
      2017 Annual Research Report
  • [Presentation] フィードバック・リン酸化によるERKシグナル制御機構の数理シミュレーション解析2018

    • Author(s)
      久保田裕二、武川睦寛
    • Organizer
      第1回MMDS、医科学研究所、新領域創成科学研究科合同ワークショップ
    • Related Report
      2017 Annual Research Report
  • [Presentation] 癌抑制遺伝子MKK4のフィードバック・リン酸化の機能解析2018

    • Author(s)
      森泉寿士, 中村貴紀, 武川睦寛
    • Organizer
      新学術領域 数理シグナル 第二回 公開シンポジウム
    • Related Report
      2017 Annual Research Report
  • [Presentation] Aberrant post-translational modifications of the MEK MAPKK in cancer.2017

    • Author(s)
      Mutsuhiro Takekawa
    • Organizer
      OIST Seminar
    • Place of Presentation
      OIST(沖縄)
    • Year and Date
      2017-02-22
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] MAPKシグナルおよびストレス顆粒形成による細胞機能の制御と疾患2017

    • Author(s)
      武川睦寛
    • Organizer
      新学術領域「数理シグナル」第一回公開シンポジウム「数理シグナル」学術領域の創出
    • Place of Presentation
      東京大学(東京)
    • Year and Date
      2017-02-11
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Aberrant regulation of MAPK signaling pathways in cancer.2017

    • Author(s)
      Takekawa M
    • Organizer
      The 48th international symposium of the Princess Takamatsu cancer research fund
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 数理科学を活用した生命・医科学研究2017

    • Author(s)
      武川睦寛
    • Organizer
      数学教育学会2017夏季研究会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 数理解析を活用した中心体複製制御機構の解明2017

    • Author(s)
      武川睦寛
    • Organizer
      2017年度生命科学系学会合同年次大会(ConBio2017)ワークショップ
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] A novel method for the detection of O-GlcNAc-modified proteins: WGA-based lectin affinity gel electrophoresis (WGA-SDS-PAGE)2017

    • Author(s)
      Yuji Kubota, Ko Fujioka and Mutsuhiro Takekawa
    • Organizer
      プロテイン・アイランド松山
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Comprehensive analysis of stress granule components2017

    • Author(s)
      Daichi Fujikawa, Takanori Nakamura and Mutsuhiro Takekawa
    • Organizer
      CIMR(Cambridge Institute for Medical Research)-University of Tokyo Symposium 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Comprehensive analysis of stress granule components2017

    • Author(s)
      Daichi Fujikawa, Takanori Nakamura and Mutsuhiro Takekawa
    • Organizer
      Dundee-Tokyo Symposium 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Functional analysis of feedback-phosphorylation of MKK4 by MAPKs2017

    • Author(s)
      Hisashi Moriizumi, Takanori Nakamura and Mutsuhiro Takekawa
    • Organizer
      AACR Annual Meeting 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] The molecular mechanisms that maintain the numerical integrity of centrosomes under stress2017

    • Author(s)
      Takanori Nakamura and Mutsuhiro Takekawa
    • Organizer
      EMBO Conference “Centrosomes and Spindle Pole Bodies”
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Functional analysis of a novel ERK substrate, MCRIP12017

    • Author(s)
      Jane Weng, Takanori Nakamura and Mutsuhiro Takekawa
    • Organizer
      24th East Asia Joint Symposium on Biomedical Research
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Functional analysis of a novel ERK substrate, MCRIP12017

    • Author(s)
      Jane Weng, Takanori Nakamura and Mutsuhiro Takekawa
    • Organizer
      12th International Symposium of the institute Network
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 数理解析に基づくMAPKシグナルと生命機能制御機構の解明2017

    • Author(s)
      武川睦寛
    • Organizer
      新学術領域「数理シグナル」領域推進会議
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 中心体複製開始を司るPLK4中心体局在機構の解明2017

    • Author(s)
      中村貴紀、西住(渡海)紀子、中澤嵩、鈴木貴、武川睦寛
    • Organizer
      2017年度生命科学系学会合同年次大会(ConBio2017)
    • Related Report
      2017 Annual Research Report
  • [Presentation] Identification of a novel redox-sensor that mediates delayed activation of stress-responsive MAPKs by oxidative stress2017

    • Author(s)
      Moe Matsushita, Takanori Nakamura and Mutsuhiro Takekawa
    • Organizer
      IMSUT G2リトリート
    • Related Report
      2017 Annual Research Report
  • [Presentation] Identification and phosphorylation analysis of a novel MAPK substrate2017

    • Author(s)
      Sae Uchida, Yuji Kubota, Mutsuhiro Takekawa
    • Organizer
      IMSUT G2リトリート
    • Related Report
      2017 Annual Research Report
  • [Presentation] ストレス顆粒の形成機構および生理機能の解明2017

    • Author(s)
      藤川大地、中村貴紀、武川睦寛
    • Organizer
      新学術領域研究 数理シグナル 第1回若手ワークショップ
    • Related Report
      2017 Annual Research Report
  • [Presentation] 癌抑制遺伝子MKK4のフィードバック・リン酸化の機能解析2017

    • Author(s)
      森泉寿士、中村貴紀、武川睦寛
    • Organizer
      新学術領域研究 数理シグナル 第1回若手ワークショップ
    • Related Report
      2017 Annual Research Report
  • [Presentation] 癌および先天性Ras/MAPK 症候群におけるMEK 変異体の異常活性化機構の解明と特異的阻害剤の同定2017

    • Author(s)
      久保田裕二、武川睦寛
    • Organizer
      新学術領域研究 数理シグナル 第1回若手ワークショップ
    • Related Report
      2017 Annual Research Report
  • [Presentation] エクソソーム中に蓄積するがん特異的miRNAの同定およびその早期診断マーカーとしての応用2017

    • Author(s)
      広瀬思帆、久保田裕二、武川睦寛
    • Organizer
      GLAFS研究進捗状況報告会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 蛋白質O-GlcNAc化によるMAPK経路の新たな制御メカニズムの解明2017

    • Author(s)
      藤岡興、久保田裕二、武川睦寛
    • Organizer
      第54回日本臨床分子医学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] シグナル伝達異常によって発現誘導される長鎖非コードRNAの同定2017

    • Author(s)
      中野雄太、久保田裕二、武川睦寛
    • Organizer
      第54回日本臨床分子医学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Identification of novel ERK substrates by yeast three hybrid screening2017

    • Author(s)
      Seina Ohe, Yuji Kubota and Mutsuhiro Takekawa
    • Organizer
      東京大学生命科学シンポジウム
    • Related Report
      2017 Annual Research Report
  • [Presentation] Functional analysis of feedback-phosphorylation of MKK4 by MAPKs2017

    • Author(s)
      Hisashi Moriizumi, Takanori Nakamura and Mutsuhiro Takekawa
    • Organizer
      第76回日本癌学会学術総会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Identification of a novel protein that is induced by hyperactiveation of the ERK pathway2017

    • Author(s)
      Yusuke Takagi, Yuji Kubota and Mutsuhiro Takekawa
    • Organizer
      第76回日本癌学会学術総会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Analysis of a novel O-GlcNAc protein involved in the MAPK pathway2017

    • Author(s)
      Ko Fujioka, Yuji Kubota and Mutsuhiro Takekawa
    • Organizer
      第76回日本癌学会学術総会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Negative regulation of the ERK pathway by caspase-mediated cleavage of MEK1 during apoptosis.2017

    • Author(s)
      Yuji Kubota, Tomoyuki Tsuchiya and Mutsuhiro Takekawa
    • Organizer
      第76回日本癌学会学術総会
    • Related Report
      2017 Annual Research Report
  • [Presentation] ストレス応答キナーゼMTK1による新たなストレス感知・応答機構2017

    • Author(s)
      松下萌恵、中村貴紀、武川睦寛
    • Organizer
      2017年度生命科学系学会合同年次大会(ConBio2017)
    • Related Report
      2017 Annual Research Report
  • [Presentation] ERK経路の異常活性化により発現が亢進する新規遺伝子の同定と機能解析2017

    • Author(s)
      高木祐輔、久保田裕二、武川睦寛
    • Organizer
      2017年度生命科学系学会合同年次大会(ConBio2017)
    • Related Report
      2017 Annual Research Report
  • [Presentation] シグナル伝達異常によって発現誘導される長鎖非コードRNAの同定と機能解析2017

    • Author(s)
      中野雄太、久保田裕二、武川睦寛
    • Organizer
      2017年度生命科学系学会合同年次大会(ConBio2017)
    • Related Report
      2017 Annual Research Report
  • [Presentation] 蛋白質O-GlcNAc化を定量的かつ簡便に検出する新たな解析方法の開発2017

    • Author(s)
      久保田裕二、藤岡興、武川睦寛
    • Organizer
      2017年度生命科学系学会合同年次大会(ConBio2017)
    • Related Report
      2017 Annual Research Report
  • [Presentation] ストレス応答MAPK経路によって制御されるmiRNAの機能解析2017

    • Author(s)
      渡海紀子、中村貴紀、武川睦寛
    • Organizer
      2017年度生命科学系学会合同年次大会(ConBio2017)
    • Related Report
      2017 Annual Research Report
  • [Presentation] 新規ERK基質分子MCRIP1の生理機能解析2017

    • Author(s)
      Jane Weng、中村貴紀、武川睦寛
    • Organizer
      2017年度生命科学系学会合同年次大会(ConBio2017)
    • Related Report
      2017 Annual Research Report
  • [Presentation] ストレス顆粒形成によるストレス応答の制御と疾患2016

    • Author(s)
      武川睦寛
    • Organizer
      Science Medical Frontier Forum
    • Place of Presentation
      TKPガーデンシティー品川(東京)
    • Year and Date
      2016-12-08
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] The molecular mechanisms that maintain the numerical integrity of centrosomes2016

    • Author(s)
      Takanori Nakamura and Mutsuhiro Takekawa
    • Organizer
      American Society of Cell Biology (ASCB) annual meeting
    • Place of Presentation
      San Francisco (USA)
    • Year and Date
      2016-12-03
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] フィードバック・リン酸化によるERKシグナルと発癌の制御2016

    • Author(s)
      武川睦寛
    • Organizer
      第39回日本分子生物学会年会シンポジウム
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Year and Date
      2016-11-30
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] ストレス応答MAPK経路依存的に発現調節されるmiRNAの同定2016

    • Author(s)
      西住(渡海)紀子、中村貴紀、武川睦寛
    • Organizer
      第39回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Year and Date
      2016-11-30
    • Related Report
      2016 Annual Research Report
  • [Presentation] 酵母Three Hybrid法による新規ERK基質分子の同定と生理機能の解明2016

    • Author(s)
      大江星菜, 久保田裕二、武川睦寛
    • Organizer
      第39回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Year and Date
      2016-11-30
    • Related Report
      2016 Annual Research Report
  • [Presentation] フォスタグ技術とプロテオミクス情報を活用した細胞内MEK1リン酸化ダイナミクスのプロファイリング2016

    • Author(s)
      木下英司、木下恵美子、久保田裕二、武川睦寛、小池透
    • Organizer
      第39回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Year and Date
      2016-11-30
    • Related Report
      2016 Annual Research Report
  • [Presentation] Comprehensive analysis of stress granule components2016

    • Author(s)
      Zizheng Li and Mutsuhiro Takekawa
    • Organizer
      IMSUT G2 retreat
    • Place of Presentation
      検見川セミナーハウス(千葉)
    • Year and Date
      2016-11-14
    • Related Report
      2016 Annual Research Report
  • [Presentation] Identification of ERK-inducible long non-coding RNAs that are highly expressed in cancer2016

    • Author(s)
      Yuta Nakano and Mutshiro Takekawa
    • Organizer
      IMSUT G2 retreat
    • Place of Presentation
      検見川セミナーハウス(千葉)
    • Year and Date
      2016-11-14
    • Related Report
      2016 Annual Research Report
  • [Presentation] Dysregulation of cell signaling pathways in cancer2016

    • Author(s)
      武川睦寛
    • Organizer
      第75回日本癌学会学術総会「がん研究入門コース1」
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Year and Date
      2016-10-06
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Functional analysis of feedback-phosphorylation of MKK4 by MAPKs2016

    • Author(s)
      Moriizumi Hisashi, Takanori Nakamura and Mutsuhiro Takekawa
    • Organizer
      第75回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Year and Date
      2016-10-06
    • Related Report
      2016 Annual Research Report
  • [Presentation] DUSP4の発現低下は膵上皮内癌から浸潤癌への進展に関与する2016

    • Author(s)
      Naoki Hijiya, Yoshiyuki Tsukamoto, Chisato Nakata, Tomoki Kai, Keiko Matsuura, Masafumi Inomata, Kuniaki Shirao, Hiromu Mori, Masao Seto, Masahiro Aoki, Mutsuhiro Takekawa, Masatsugu Moriyama
    • Organizer
      第75回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Year and Date
      2016-10-06
    • Related Report
      2016 Annual Research Report
  • [Presentation] MCRIP1, a novel ERK substrate, mediates ERK-induced epigenetic gene silencing during epithelial-to-mesenchymal transition2016

    • Author(s)
      Mutsuhiro Takekawa
    • Organizer
      15th Karolinska Institute Cancer Retreat
    • Place of Presentation
      Stockholm (Sweden)
    • Year and Date
      2016-09-26
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Functional analysis of feedback-phosphorylation of MKK4 by MAPKs2016

    • Author(s)
      Moriizumi Hisashi, Takanori Nakamura and Mutsuhito Takekawa
    • Organizer
      IARU International Symposium on Aging, Longevity and Health
    • Place of Presentation
      東京大学(東京)
    • Year and Date
      2016-09-26
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 膵上皮内癌が浸潤癌へ進展するメカニズムの解明2016

    • Author(s)
      守山正胤、泥谷直樹、塚本善之、柴田浩平、猪股雅史、森宣、白尾國昭、竹内一郎、瀬戸加大、青木正博、武川睦寛
    • Organizer
      第27回日本消化器癌発生学会総会
    • Place of Presentation
      城山観光ホテル(鹿児島)
    • Year and Date
      2016-09-15
    • Related Report
      2016 Annual Research Report
  • [Presentation] ストレス顆粒形成によるストレス誘導アポトーシスの制御と活性酸素によるその破綻2016

    • Author(s)
      武川睦寛
    • Organizer
      第67回日本電気泳動学会総会特別講演
    • Place of Presentation
      釧路市観光国際交流センター(釧路)
    • Year and Date
      2016-08-27
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 数理解析に基づくMAPKシグナルと生命機能制御機構の解明2016

    • Author(s)
      武川睦寛
    • Organizer
      新学術領域「数理シグナル」計画班合同会議
    • Place of Presentation
      東京大学(東京)
    • Year and Date
      2016-08-17
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Comprehensive analysis of stress granule components2016

    • Author(s)
      李 子政、武川睦寛
    • Organizer
      第9回CBMS発表会
    • Place of Presentation
      東京大学(東京)
    • Year and Date
      2016-07-25
    • Related Report
      2016 Annual Research Report
  • [Presentation] Molecular mechanism by which PLK4 is recruited to centrosomes2016

    • Author(s)
      杉崎 麻友、武川睦寛
    • Organizer
      第9回CBMS発表会
    • Place of Presentation
      東京大学(東京)
    • Year and Date
      2016-07-25
    • Related Report
      2016 Annual Research Report
  • [Presentation] TIA1 oxidation inhibits stress granule assembly and sensitizes cells to stress-induced apoptosis2016

    • Author(s)
      武川睦寛
    • Organizer
      第一回RNA顆粒/RNAタンパク質複合体研究会
    • Place of Presentation
      岡崎コンファレンスセンター(岡崎)
    • Year and Date
      2016-07-16
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Remarks] 新学術領域研究「数理シグナル」ホームページ

    • URL

      http://math-signal.umin.jp/

    • Related Report
      2020 Annual Research Report 2019 Annual Research Report
  • [Remarks] http://www.ims.u-tokyo.ac.jp/dcsmm/DCSMM/Top.html

    • Related Report
      2017 Annual Research Report
  • [Remarks] http://math-signal.umin.jp/index.html

    • Related Report
      2017 Annual Research Report
  • [Remarks] 新学術領域「数理シグナル」ホームページ

    • URL

      http://math-signal.umin.jp/

    • Related Report
      2016 Annual Research Report
  • [Funded Workshop] 1st International symposium on Interdisciplinary Approaches to Integrative Understanding of Biological Signaling Networks2019

    • Related Report
      2018 Annual Research Report

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Published: 2016-07-04   Modified: 2022-02-28  

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