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Brain information dynamics underlying multi-area interconnectivity and parallel processing

Administrative Group

Project AreaBrain information dynamics underlying multi-area interconnectivity and parallel processing
Project/Area Number 17H06308
Research Category

Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

Allocation TypeSingle-year Grants
Review Section Complex systems
Research InstitutionThe University of Tokyo

Principal Investigator

Bito Haruhiko  東京大学, 大学院医学系研究科(医学部), 教授 (00291964)

Co-Investigator(Kenkyū-buntansha) 松崎 政紀  東京大学, 大学院医学系研究科(医学部), 教授 (50353438)
喜多村 和郎  山梨大学, 大学院総合研究部, 教授 (60423159)
川口 泰雄  玉川大学, 脳科学研究所, 研究員 (40169694)
石井 信  京都大学, 情報学研究科, 教授 (90294280)
Project Period (FY) 2017-06-30 – 2022-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥322,270,000 (Direct Cost: ¥247,900,000、Indirect Cost: ¥74,370,000)
Fiscal Year 2021: ¥48,360,000 (Direct Cost: ¥37,200,000、Indirect Cost: ¥11,160,000)
Fiscal Year 2020: ¥48,360,000 (Direct Cost: ¥37,200,000、Indirect Cost: ¥11,160,000)
Fiscal Year 2019: ¥48,360,000 (Direct Cost: ¥37,200,000、Indirect Cost: ¥11,160,000)
Fiscal Year 2018: ¥47,840,000 (Direct Cost: ¥36,800,000、Indirect Cost: ¥11,040,000)
Fiscal Year 2017: ¥129,350,000 (Direct Cost: ¥99,500,000、Indirect Cost: ¥29,850,000)
Keywords脳・神経 / 神経回路 / カルシウム / 情報工学 / 神経科学 / 情報後学
Outline of Final Research Achievements

In order to establish "brain information dynamics" as a new academic discipline and foundation for elucidating the bioinformatics structure of brain dynamics, three research projects were promoted: A01 Brain Information Decoding (decoding brain information dynamics based on information measurement and structural design, and promoting integrated theory), A02 Brain Information Measurement (analyzing brain information dynamics during cognitive and motor tasks by developing and using new neural activity sensors with the highest performance), and A03 Brain Information Network Construction (elucidating brain information dynamics in human decision making and standardizing methodology for developing general artificial intelligence).

Academic Significance and Societal Importance of the Research Achievements

脳情報動態の生命情報工学的構造を解明する新しい学問的基盤「脳情報動態学」のもたらす成果により、我が国の脳科学の抜本的発展とライフサイエンス・情報科学全般との融合が推進され、脳神経医学の水準向上・強化にも大いにつながると考えられる。

Report

(6 results)
  • 2022 Final Research Report ( PDF )
  • 2021 Annual Research Report
  • 2020 Annual Research Report
  • 2019 Annual Research Report
  • 2018 Annual Research Report
  • 2017 Annual Research Report
  • Research Products

    (30 results)

All 2022 2021 2020 2019 2018 2017 Other

All Int'l Joint Research (2 results) Journal Article (6 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 6 results,  Open Access: 5 results) Presentation (12 results) (of which Int'l Joint Research: 7 results,  Invited: 12 results) Remarks (2 results) Funded Workshop (8 results)

  • [Int'l Joint Research] Stanford University(米国)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] Stanford University(米国)

    • Related Report
      2018 Annual Research Report
  • [Journal Article] A Flp-dependent G-CaMP9a transgenic mouse for neuronal imaging in vivo2022

    • Author(s)
      Sakamoto Masayuki, Inoue Masatoshi, Takeuchi Atsuya, Kobari Shigetaka, Yokoyama Tatsushi, Horigane Shin-ichiro, Takemoto-Kimura Sayaka, Abe Manabu, Sakimura Kenji, Kano Masanobu, Kitamura Kazuo, Fujii Hajime, Bito Haruhiko
    • Journal Title

      Cell Reports Methods

      Volume: 2 Issue: 2 Pages: 100168-100168

    • DOI

      10.1016/j.crmeth.2022.100168

    • URL

      https://pure.teikyo.jp/en/publications/8054d3cd-fd72-478d-8c3f-48fd86436357

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Transition Motion Synthesis for Object Interaction based on Learning Transition Strategies2022

    • Author(s)
      Jaepyung Hwang, Gangrae Park, Taesoo Kwon, Shin Ishii
    • Journal Title

      Computer Graphics Forum

      Volume: 41 Issue: 6 Pages: 37-50

    • DOI

      10.1111/cgf.14499

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Gastrin-releasing peptide regulates fear learning under stressed conditions via activation of the amygdalostriatal transition area2022

    • Author(s)
      Goto Fumiko、Kiyama Yuji、Ogawa Itone、Okuno Hiroyuki、Ichise Taeko、Ichise Hirotake、Anai Motonobu、Kodama Tatsuhiko、Yoshida Nobuaki、Bito Haruhiko、Manabe Toshiya
    • Journal Title

      Molecular Psychiatry

      Volume: - Issue: 3 Pages: 1694-1703

    • DOI

      10.1038/s41380-021-01408-3

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Comparative Studies of the Fluorescence Properties of Microbial Rhodopsins: Spontaneous Emission Versus Photointermediate Fluorescence2020

    • Author(s)
      Kojima Keiichi、Kurihara Rika、Sakamoto Masayuki、Takanashi Tsukasa、Kuramochi Hikaru、Zhang Xiao Min、Bito Haruhiko、Tahara Tahei、Sudo Yuki
    • Journal Title

      The Journal of Physical Chemistry B

      Volume: 124 Issue: 34 Pages: 7361-7367

    • DOI

      10.1021/acs.jpcb.0c06560

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Modular organization of cerebellar climbing fiber inputs during goal-directed behavior.2019

    • Author(s)
      Tsutsumi S, Hidaka N, Isomura Y, Matsuzaki M, Sakimura K, Kano M, Kitamura K.
    • Journal Title

      Elife.

      Volume: 8

    • DOI

      10.7554/elife.47021

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Rational Engineering of XCaMPs, a Multicolor GECI Suite for In Vivo Imaging of Complex Brain Circuit Dynamics2019

    • Author(s)
      Inoue M, Takeuchi A, Manita S, Horigane S-i, Sakamoto M, Kawakami R, Yamaguchi K, Otomo K, Yokoyama H, Kim R, Yokoyama T, Takemoto-Kimura S, Abe M, Okamura M, Kondo Y, Quirin S, Ramakrishnan C, Imamura T, Sakimura K, Nemoto T, Kano M, Fujii H, Deisseroth K, Kitamura K, Bito H.
    • Journal Title

      Cell

      Volume: 177 Issue: 5 Pages: 1346

    • DOI

      10.1016/j.cell.2019.04.007

    • URL

      https://localhost/en/publications/a48843c1-543d-4414-a93c-3cab0e1df627

    • Related Report
      2019 Annual Research Report 2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] Multiplex imaging of neural activity and signaling dynamics2022

    • Author(s)
      Bito H
    • Organizer
      Biennial Meeting of the International Society for Neurochemistry -held in conjunction with the Asian-Pacific Society for Neurochemistry,
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Lessons learned from elucidating calcium-dependent neural circuit control mechanisms2021

    • Author(s)
      Bito H.
    • Organizer
      94th Annual Meeting of the Japanese Pharmacological Society
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] Plasticity and memory mechanisms in vivo. - Arc-dependent regulation of long-term synaptic plasticity and memory2020

    • Author(s)
      Bito H
    • Organizer
      Stockholm Trio - University of Tokyo Strategic Partnership Workshop 2020
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Multiplex Imaging of Neural Activity and Signaling Dynamics.2019

    • Author(s)
      Bito H
    • Organizer
      10th IBRO World Congress 2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Functional connectivity between the neocortex and the cerebellum2019

    • Author(s)
      Kitamura K
    • Organizer
      10th IBRO World Congress 2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Arc-haeology of long-term memory2019

    • Author(s)
      Bito H
    • Organizer
      UK Dementia Research Institute Synapse Symposium
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Multiplex imaging of neural activity and signaling dynamics2019

    • Author(s)
      Bito H
    • Organizer
      Cajal Advanced Neuroscience Training Programme 2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Multiplex imaging of neural activity and signaling dynamics.2018

    • Author(s)
      Haruhiko Bito
    • Organizer
      IDG/McGovern Institute for Brain Research Seminar at Peking University
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Multiplex imaging of neural activity and signaling dynamics2018

    • Author(s)
      Haruhiko Bito, Masatoshi Inoue, Masayuki Sakamoto, Hajime Fujii
    • Organizer
      18th World Congress of Basic and Clinical Pharmacology (WCP2018)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Towards multiplex imaging of neural activity and signaling dynamics2018

    • Author(s)
      Haruhiko Bito
    • Organizer
      New York University Neuroscience Institute Lecture
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Multiplex imaging of neural activity and signaling dynamics.2018

    • Author(s)
      Bito H.
    • Organizer
      Neuroscience, Physiology and Pharmacology Seminar Series, Cruciform LT2, Univeriity College London, London UK,
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] CREB-Arc signaling in long-term memory formation.2017

    • Author(s)
      Bito H.
    • Organizer
      Department of Neuroscience Seminar, Karolinska Institutet, Stockholm, Sweden.
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Remarks] 脳情報動態を規定する多領野連関と並列処理

    • URL

      http://brainfodynamics.umin.jp/

    • Related Report
      2019 Annual Research Report
  • [Remarks] 文部科学省 新学術領域研究 脳情報動態を規定する多領野連関と並列処理(脳情報動態)

    • URL

      http://brainfodynamics.umin.jp/

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
  • [Funded Workshop] Young Investigator Symposium on Brain Information Dynamics2022

    • Related Report
      2021 Annual Research Report
  • [Funded Workshop] 3rd International Symposium on Brain Information Dynamics2022

    • Related Report
      2020 Annual Research Report
  • [Funded Workshop] Brain and Mind Mechanism 19th Winter Workshop "Cognitive development and its disorders : From the viewpoint of predictive coding"2019

    • Related Report
      2018 Annual Research Report
  • [Funded Workshop] Systems Neuroscience Spring School 2019 "Statics and Dynamics of Neural Systems"2019

    • Related Report
      2018 Annual Research Report
  • [Funded Workshop] Symposium "Transformative technologies at the forefront of brain research” at the 18th World Congress of Basic and Clinical Pharmacology (WCP2018)2018

    • Related Report
      2018 Annual Research Report
  • [Funded Workshop] Joint Symposium of the 10th Optogenetics Research Conference and the 2nd International Symposium on Brain Information Dynamics 20182018

    • Related Report
      2018 Annual Research Report
  • [Funded Workshop] Kyoto Prize Workshop "Causal Approaches to Brain Functions through Optogenetics and Beyond2018

    • Related Report
      2018 Annual Research Report
  • [Funded Workshop] International Symposium on Brain Information Dynamics 2018“Toward understanding multi-area interconnectivity in the brain”2018

    • Related Report
      2017 Annual Research Report

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Published: 2017-07-04   Modified: 2024-01-30  

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