Preventive medicine through inflammation cellular sociology

• Project Area: Preventive medicine through inflammation cellular sociology
• Project/Area Number: 17H06391
• Research Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
• Allocation Type: Single-year Grants
• Review Section: Complex systems
• Research Institution: Tokyo University of Science (2018-2021); The University of Tokyo (2017)
• Principal Investigator: 松島 綱治 東京理科大学, 研究推進機構生命医科学研究所, 教授 (50222427)
• Co-Investigator(Kenkyū-buntansha): 橋本 真一 和歌山県立医科大学, 先端医学研究所, 教授 (00313099) ; 藤渕 航 京都大学, iPS細胞研究所, 教授 (60273512)
• Project Period (FY): 2017-06-30 – 2022-03-31
• Project Status: Granted (Fiscal Year 2021)
• Budget Amount: ¥196,560,000 (Direct Cost: ¥151,200,000、Indirect Cost: ¥45,360,000); Fiscal Year 2021: ¥33,150,000 (Direct Cost: ¥25,500,000、Indirect Cost: ¥7,650,000); Fiscal Year 2020: ¥33,150,000 (Direct Cost: ¥25,500,000、Indirect Cost: ¥7,650,000); Fiscal Year 2019: ¥33,150,000 (Direct Cost: ¥25,500,000、Indirect Cost: ¥7,650,000); Fiscal Year 2018: ¥33,150,000 (Direct Cost: ¥25,500,000、Indirect Cost: ¥7,650,000); Fiscal Year 2017: ¥63,960,000 (Direct Cost: ¥49,200,000、Indirect Cost: ¥14,760,000)
• Keywords: 免疫 / 遺伝子 / 情報工学 / モデル化 / 病理学

Outline of Annual Research Achievements

本総括班研究では、包括的single-cell transcriptome、遺伝子発現データ解析、エピゲノム解析、プロテオーム解析、リピドーム解析、マイクロバイオーム解析、遺伝子組換え動物作製を支援する炎症細胞社会解析センターを設置し、領域横断で使用可能な炎症細胞社会の解析プラットフォームを整備し、環境 ストレス、ゲノム社会予防医学、脂質代謝生化学、循環器・肝臓・腎臓臨床医学、分子標的予防医学、計算生物学など多様なバックグランドを持つ研究者の連携を強力に促進することを目的としている。2019度は、オンラインコラボレーションソフトウェアSLACK、オンラインミーティングシステムWebExを通じて情報解析支援チームと計画研究班、公募研究班の連携体制を強化した。また、各計画研究班、公募研究班の疾患モデル解析について、解析対象の設定から単細胞懸濁液の調製、調整した細胞サンプルのquality controlを含めた支援を行い、包括的single-cell transcriptomeをすすめた。これまでに肺、肝臓、腎臓、膵臓、腸管、皮膚などの炎症疾患モデルおよび疾患患者iPS由来細胞などについて包括的single-cell transcriptomeを行い、データを取得している。班会議や共同研究推進委員会などを通じて領域内での情報交換や共同研究を推進するとともに、2019年11月には包括的single-cell transcriptomeを用いた疾患研究を牽引する世界的な研究者を招聘した国際シンポジウムを開催した。また、一般向けの科学コミュニケーション活動「免疫ふしぎ未来」を通じて本学術領域の広報活動を行った。

Current Status of Research Progress

1: Research has progressed more than it was originally planned.

Reason

2019年度は、計画班、公募班のsingle-cell transcriptome解析のニーズが増加し、これに対応するため総括班が中心となって単一細胞懸濁液の調製が困難な臓器の細胞調製指導・支援を積極的に行った。また、DNAバーコード抗体で細胞サンプルを標識するマルチプレックス解析を実用化しすることで、高額なsingle-cell transcriptome解析のコストのためこれまで困難であった実験群やbiological replicateを増やすことが可能になった。情報解析支援についても、計画班・公募班と、総括班情報解析担当者間で密な連携体制が構築できている。

Strategy for Future Research Activity

引き続き、各計画研究、公募研究を支援する。領域の運営方針、研究支援内容は、年2回開催する班会議にて主に策定するが、必要に応じて随時委員会を開催し、領域代表(総括班研究代表者)の承認のもと、柔軟に対応する。1) Single-cell transcriptome: Nx-1マイクロウェルデバイスおよびRhapsodyシステムを用い、固有のバーコードを持つ1細胞由来cDNA libraryを数千個の細胞について作成し、次世代シーケンサーを用いて各細胞の遺伝子発現情報を取得する。2）　遺伝子発現データ解析: 発現変動遺伝子抽出、GO解析、クラスター解析、パスウェイ解析などを支援する。3） エピゲノム解析: MSD-AFLP法などを用いたDNAメチル化解析、ChIP-seqなどによるヒストン修飾解析を支援する。4) プロテオーム解析: 蛍光標識2次元ディファレンスゲル電気泳動解析システムと質量分析装置(TOF-MS)を用いて標的タンパク質の同定を支援する。 5) リピドーム解析: 液体クロマトグラフィーと三連四重極型質量分析計(TripleQ)を組み合わせたLCMS/MS、ならびに四重極飛行時間型質量分析計(Q-TOF)を用いて、リピドーム解析を支援する。6) マイクロバイオーム解析: 次世代シーケンサーを用いて、細菌叢の16S rRNA遺伝子配列に基づく網羅的解析を行い、腸内 細菌叢遺伝子情報解析を支援する。7) 遺伝子組換え動物作製支援: CRISPR/Cas9などの遺伝子編集技術を用いて、ノックアウトマウス、レポーターマウスの作製を支援する。COVID19が収束しない場合、班会議はオンラインで行い、また公開シンポジウムは実施しない。

Research Products

• [Journal Article] Analyzing Leukocyte Migration Trajectories by Deformable Image Matching (2019)
  • Author(s): Shigeta Hironori、Seno Shigeto、Nishizawa Shino、Uchida Yutaka、Kikuta Junichi、Ishii Masaru、Matsuda Hideo
  • Journal Title: IEEE Xplore Volume: 19243594 Pages: 94-98
  • DOI: 10.1109/bibe.2019.00025
  • Peer Reviewed / Open Access
• [Journal Article] Single-cell transcriptome analysis of mouse leukocytes in inflammatory stimulation. (2019)
  • Author(s): Osato N, Shigeta H, Seno S, Uchida Y, Kikuta J, Ishii M, Matsuda H.
  • Journal Title: IEEE Xplore Volume: 19351527 Pages: 1229-1231
  • DOI: 10.1109/bibm47256.2019.8983394
  • Peer Reviewed / Open Access
• [Journal Article] Lipopolysaccharide-induced Expansion of Histidine Decarboxylase-Expressing Ly6G + Myeloid Cells Identified by Exploiting Histidine Decarboxylase BAC-GFP Transgenic Mice (2019)
  • Author(s): Takai J, Ohtsu H, Sato A, Uemura S, Fujimura T, Yamamoto M, Moriguchi T.
  • Journal Title: Scientific Reports Volume: 9(1) Pages: 15603-15603
  • DOI: 10.1038/s41598-019-51716-6
  • Peer Reviewed / Open Access
• [Journal Article] Epidermal loss of phospholipase Cδ1 attenuates irritant contact dermatitis (2019)
  • Author(s): Shiratori K, Kanemaru K, Ogura T, Nakajima A, Sugizaki Y, Fukuyama T, Iwakura Y, Nakamura Y, Fukami K.
  • Journal Title: Biochem. Biophys. Res. Commun. Volume: 511 Pages: 330-335
  • DOI: 10.1016/j.bbrc.2019.02.046
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] IL-1β Plays an Important Role in Pressure Overload-Induced Atrial Fibrillation in Mice (2019)
  • Author(s): Matsushita N, Ishida N, Ibi M, Saito M, Takahashi M, Taniguchi S, Iwakura Y, Morino Y, Taira E, Sawa Y, Hirose M
  • Journal Title: Biol. Pharm. Bull. Volume: 42 Issue: 4 Pages: 543-546
  • DOI: 10.1248/bpb.b18-00363
  • NAID: 130007622152
  • ISSN: 0918-6158, 1347-5215
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Spontaneous atopic dermataitis in mice with a defective skin barrier is independent of ILC2 and mediated by IL-1β. (2019)
  • Author(s): Schwartz, C., Moran, T., Saunders, S. P., Kaszlikowska, A., Floudas, A., Bom, J., Nunez, G., Iwakura, Y., O’Neill, L., Irvine, A. D., McKenzie, A. N. J., Ogg, G., Walsh, P. T., Demengeot, J., and Fallon, P. G.
  • Journal Title: Allergy Volume: 74 Pages: 1920-1933
  • DOI: 10.1111/all.13801
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Myeloid C-type lectin receptors in skin/mucoepithelial diseases and tumors. (2019)
  • Author(s): Tang, C., Makusheva, Y., Sun, H., Han, W., and Iwakura, Y.
  • Journal Title: Journal of Leukocyte Biology Volume: 106 Pages: 903-917
  • DOI: 10.1002/jlb.2ri0119-031r
  • Peer Reviewed / Open Access
• [Journal Article] Uncoupling the senescence-associated secretory phenotype from cell cycle exit via IL-1 inactivation unveils its pro-tumorigenic role. (2019)
  • Author(s): Lau, L., Porciuncula, A., Yu, A., Iwakura, Y., and David, G.
  • Journal Title: Molecular and Cellular Biology Volume: 39 Pages: 18-35
  • DOI: 10.1128/mcb.00586-18
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] arge scale cacium imaging of the cerebellar vermis during sensory stimulus unravels two response’s components that differ in their spatiotemporal properties. (2019)
  • Author(s): Byk, H., Huang, G. J., Iwakura, Y., and Yarom, Y.
  • Journal Title: Frontiers in Systems Neuroscience Volume: 13 Pages: 1-15
  • DOI: 10.3389/fnsys.2019.00018
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] CARD9+ microglia promote antifungal immunity via IL-1β- and CXCL1-mediated neutrophil recruitment. (2019)
  • Author(s): Drummond, R. A., Swamydas, M., Oikonomou, V., Zhai, B., Dambuza, I. M., Schaefer, B. C., Bohrer, A. C., Mayer-Barber, K. D., Lira, S. A., Iwakura, Y., Filler, S. G., Brown, G. D., Hube, B., Naglik, J. R., Hohl, T. M., and Lionakis, M. S.
  • Journal Title: Nature Immunology Volume: 20 Pages: 559-570
  • DOI: 10.1038/s41590-019-0377-2
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Dectin-2?induced CCL2 production in tissue-resident macrophages ignites cardiac arteritis (2019)
  • Author(s): Miyabe Chie、Miyabe Yoshishige、Bricio-Moreno Laura、Lian Jeffrey、Rahimi Rod A.、Miura Noriko N.、Ohno Naohito、Iwakura Yoichiro、Kawakami Tamihiro、Luster Andrew D.
  • Journal Title: J. Clin. Invest Volume: 129 Pages: 3610-3624
  • DOI: 10.1172/jci123778
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] CCR8 leads to eosinophil migration and regulates neutrophil migration in murine allergic enteritis. (2019)
  • Author(s): Blanco-Perez, F., Kato, Y., Gonzalez-Menendez, I., Laino, J., Ohbayashi, M., Burggraf, M., Krause, M., Kirberg, J., Iwakura, Y., Martella, M., Quintanilla-Martinez, L., Shibata, N., Vieths, S., Scheurer, S., and Toda, M.
  • Journal Title: Scientific Reports Volume: 9 Pages: 9608-9608
  • DOI: 10.1038/s41598-019-45653-7
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] AIM2 inflammasome-derived IL-1β induces postoperative ileus in mice. (2019)
  • Author(s): Hupa, K. J., Stein, K., Schneider, R., Lysson, M., Schneiker, B., Hornung, V., Latz, E., Iwakura, Y., Kalff, J. C., and Wehner, S.
  • Journal Title: Scientific Reports Volume: 9 Pages: 10602-10602
  • DOI: 10.1038/s41598-019-46968-1
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Cutaneous p38 mitogen-activated protein kinase activation triggers psoriatic dermatitis. (2019)
  • Author(s): Sakurai K, Dainichi T, Garcet S, Tsuchiya S, Yamamoto Y, Kitoh A, Honda T, Nomura T, Egawa G, Otsuka A, Nakajima S, Matsumoto R, Nakano Y, Otsuka M, Iwakura Y, Grinberg-Bleyer Y, Ghosh S, Sugimoto Y, Guttman-Yassky E, Krueger JG, Kabashima K.
  • Journal Title: J. Allergy Clin. Immunol. Volume: 144(4) Pages: 1036-1049
  • DOI: 10.1016/j.jaci.2019.06.019
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Defect of interferon γ leads to impaired wound healing through prolonged neutrophilic inflammatory response and enhanced MMP-2 activation. (2019)
  • Author(s): Kanno E, Tanno H, Masaki A, Sasaki A, Sato N, Goto M, Shisai M, Yamaguchi K, Takagi N, Shoji M, Kitai Y, Sato K, Kasamatsu J, Ishii K, Miyasaka T, Kawakami K, Imai Y, Iwakura Y, Maruyama R, Tachi M, Kawakami K.
  • Journal Title: nt. J. Mol. Sci. Volume: 20(22) Pages: 5657-5657
  • DOI: 10.3390/ijms20225657
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Pevonedistat, a Neuronal Precursor Cell-Expressed Developmentally Down-Regulated Protein 8-Activating Enzyme Inhibitor, Is a Potent Inhibitor of Hepatitis B Virus (2019)
  • Author(s): Sekiba Kazuma、Otsuka Motoyuki、Ohno Motoko、Yamagami Mari、Kishikawa Takahiro、Seimiya Takahiro、Suzuki Tatsunori、Tanaka Eri、Ishibashi Rei、Funato Kazuyoshi、Koike Kazuhiko
  • Journal Title: Hepatology Volume: in press Pages: 1903-1915
  • DOI: 10.1002/hep.30491
  • Peer Reviewed / Open Access
• [Journal Article] Liver stiffness measurements in chronic hepatitis C: treatment evaluation and risk assessment. (2019)
  • Author(s): Nakagomi R, Tateishi R, Masuzaki R, Soroida Y, Iwai T, Kondo M, Fujiwara N, Sato M, Minami T, Uchino K, Enooku K, Nakagawa H, Asaoka Y, Kondo Y, Tanaka Y, Otsuka M, Kato N, Moriya K, Ikeda H, Koike K.
  • Journal Title: Gastroenterol Hepatol. Volume: 34 Pages: 921-928
  • DOI: 10.1111/jgh.14530
  • Peer Reviewed / Open Access
• [Journal Article] Cdkl-mediated DIAPHI phosphorylation maintains metaphase cortical tension and inactivates the spindle assembly checkpoint at anaphase. (2019)
  • Author(s): Nishimura K, Johmura Y, Deguchi K, Jiang Z, Uchida KSK, Suzuki N, Shimada M, Chiba Y, Hirota T, Yoshimura SH, Kono K, Nakanishi M.
  • Journal Title: Nat Commun. Volume: 10 Issue: 1 Pages: 1-10
  • DOI: 10.1038/s41467-019-08957-w
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Identification and isolation of splenic tissue resident macrophage subpopulations by flow cytometry (2019)
  • Author(s): Fujiyama S, Nakahashi-Oda C, Abe F, Wang Y, Sato K, Shibuya A
  • Journal Title: Int Immunol. Volume: 31(1) Pages: 51-56
  • DOI: 10.1093/intimm/dxy064
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Serum aldo-keto reductase family 1 member B10 predicts advanced liver fibrosis and fatal complications of nonalcoholic steatohepatitis. (2019)
  • Author(s): M Kanno, K Kawaguchi, M Honda, R Horii, H Takatori, T Shimakami, K Kitamura, K Arai, T Yamashita, Y Sakai, T Yamashita, E Mizukoshi, S Kaneko.
  • Journal Title: J Gastroenterol. Volume: - Pages: 549-557
  • DOI: 10.1007/s00535-019-01551-3
  • Peer Reviewed / Open Access
• [Journal Article] The Cortical Neuroimmune Regulator TANK Affects Emotional Processing and Enhances Alcohol Drinking: A Translational Study (2019)
  • Author(s): Muller CP, Chu C, Qin L, Liu C, Xu B, Gao H, Ruggeri B, Hieber S, Schneider J, Jia T, Tay N, Akira S, Satoh T, Banaschewski T, Bokde ALW, Bromberg U, Buchel C, Quinlan EB, Flor H, Frouin V, Garavan H, Gowland P, Heinz A, Ittermann B, Martinot JL, Martinot MP, Artiges E, Lemaitre H, Nees F, ..., Schumann G.
  • Journal Title: Cerebral Cortex Volume: 29 Pages: 1736-1751
  • DOI: 10.1093/cercor/bhy341
  • Peer Reviewed / Open Access
• [Journal Article] TAK1 Prevents Endothelial Apoptosis and Maintains Vascular Integrity. (2019)
  • Author(s): Naito H, Iba T, Wakabayashi T, Tai-Nagara I, Suehiro JI, Jia W, Eino D, Sakimoto S, Muramatsu F, Kidoya H, Sakurai H, Satoh T, Akira S, Kubota Y, Takakura N.
  • Journal Title: Developmental Cell Volume: 48 Pages: 151-166
  • DOI: 10.1016/j.devcel.2018.12.002
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Heterozygous Tbk1 loss has opposing effects in early and late stages of ALS in mice. (2019)
  • Author(s): Brenner D, Sieverding K, Bruno C, Luningschror P, Buck E, Mungwa S, Fischer L, Brockmann SJ, Ulmer J, Bliederhauser C, Philibert CE, Satoh T, Akira S, Boillee S, Mayer B, Sendtner M, Ludolph AC, Danzer KM, Lobsiger CS, Freischmidt A, Weishaupt JH.
  • Journal Title: J Exp Med. Volume: 216 Pages: 267-278
  • DOI: 10.1084/jem.20180729
  • Peer Reviewed / Open Access
• [Journal Article] USP15 Participates in Hepatitis C Virus Propagation through Regulation of Viral RNA Translation and Lipid Droplet Formation (2019)
  • Author(s): Kusakabe S、Suzuki T、Sugiyama Y、Haga S、Horike K、Tokunaga M、Hirano J、Zhang H、Chen DV、Ishiga H、Komoda Y、Ono C、Fukuhara T、Yamamoto M、Ikawa M、Satoh T、Akira S、Tanaka T、Moriishi Ki、Fukai M、Taketomi A、Yoshio S、Kanto T、Suzuki T、Okamoto T、Matsuura Y
  • Journal Title: J Virol. Volume: 93 Pages: 1708-1718
  • DOI: 10.1128/jvi.01708-18
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Clonal analysis revealed functional heterogeneity in cancer stem-like cell phenotypes in uterine endometrioid adenocarcinoma. (2019)
  • Author(s): Tabuchi Y, Hirohashi Y, Hashimoto S, Mariya T, Asano T, Ikeo K, Kuroda T, Mizuuchi M, Murai A, Uno S, Kawai N, Kubo T, Nakatsugawa M, Kanaseki T, Tsukahara T, Saito T, Torigoe T.
  • Journal Title: Experimental and Molecular Pathology Volume: 106 Pages: 78-88
  • DOI: 10.1016/j.yexmp.2018.11.013
  • Peer Reviewed / Open Access
• [Journal Article] Engraftment and proliferation potential of embryonic lung tissue cells in irradiated mice with emphysema (2019)
  • Author(s): Shiraishi Kazushige、Shichino Shigeyuki、Tsukui Tatsuya、Hashimoto Shinichi、Ueha Satoshi、Matsushima Kouji
  • Journal Title: Sci Rep. Volume: 9 Pages: 1-12
  • DOI: 10.1038/s41598-019-40237-x
  • Peer Reviewed / Open Access
• [Journal Article] Combined treatment with HMGN1 and anti-CD4 depleting antibody reverses T cell exhaustion and exerts robust anti-tumor effects in mice (2019)
  • Author(s): Chen Chang-Yu、Ueha Satoshi、Ishiwata Yoshiro、Yokochi Shoji、Yang De、Oppenheim Joost J.、Ogiwara Haru、Shichino Shigeyuki、Deshimaru Shungo、Shand Francis H. W.、Shibayama Shiro、Matsushima Kouji
  • Journal Title: J Immunother. Volume: 7 Pages: 21-21
  • DOI: 10.1186/s40425-019-0503-6
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Cryptococcus gattii alters immunostimulatory potential in response to the environment (2019)
  • Author(s): Ueno Keigo、Otani Yoshiko、Yanagihara Nao、Nakamura Takumi、Shimizu Kiminori、Yamagoe Satoshi、Miyazaki Yoshitsugu
  • Journal Title: Mucosal Immunol. Volume: 14 Pages: 265-276
  • DOI: 10.1371/journal.pone.0220989
  • Peer Reviewed / Open Access
• [Journal Article] Histone H3K27 Demethylase Negatively Controls the Memory Formation of Antigen-Stimulated CD8+ T Cells (2019)
  • Author(s): Yamada Takeshi、Nabe Shogo、Toriyama Koji、Suzuki Junpei、Inoue Kazuki、Imai Yuuki、Shiraishi Atsushi、Takenaka Katsuto、Yasukawa Masaki、Yamashita Masakatsu
  • Journal Title: J Immunol. Volume: 202 Pages: 1088-1098
  • DOI: 10.4049/jimmunol.1801083
  • Peer Reviewed / Open Access
• [Journal Article] Toxicological Evaluation of SiO2 Nanoparticles by Zebrafish Embryo Toxicity Test (2019)
  • Author(s): Vranic Sandra、Shimada Yasuhito、Ichihara Sahoko、Kimata Masayuki、Wu Wenting、Tanaka Toshio、Boland Sonja、Tran Lang、Ichihara Gaku
  • Journal Title: Int J Mol Sci. Volume: 20 Pages: 882-882
  • DOI: 10.3390/ijms20040882
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Mutant KCNJ3 and KCNJ5 potassium channels as novel molecular targets in bradyarrhythmias and atrial fibrillation. (2019)
  • Author(s): Yamada N, ..., Zankov DP, Shimizu A, ..., Ogita H, ..., Takashima S.
  • Journal Title: Circulation Volume: in press Pages: 2157-2169
  • DOI: 10.1161/circulationaha.118.036761
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Characteristics of Japanese Patients with Nonvalvular Atrial Fibrillation on Anticoagulant Treatment: A Descriptive Analysis of J-dabigatran Surveillance and JAPAF Study. (2019)
  • Author(s): Koretsune Y, Kusakawa K, Harada KH, Koizumi A, Uchiyama S, Atarashi H, Okumura K, Yasaka M, Yamashita T, Taniguchi A, Fukaya T, Inoue H; for J-dabigatran surveillance and JAPAF study investigators.
  • Journal Title: Cardiol Ther. Volume: 8 Pages: 43-54
  • DOI: 10.1007/s40119-019-0129-2
  • Peer Reviewed / Open Access
• [Journal Article] Moyamoya Disease Susceptibility Variant RNF213 p.R4810K Increases the Risk of Ischemic Stroke Attributable to Large-Artery Atherosclerosis (2019)
  • Author(s): Okazaki S, Koizumi A 他26名(27番目)
  • Journal Title: Circulation. Volume: 139 Pages: 295-298
  • DOI: 10.1161/circulationaha.118.038439
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Glucocorticoid receptor suppresses gene expression of Rev-erbα (Nr1d1) through interaction with the CLOCK complex (2019)
  • Author(s): Murayama Yuki, Takafumi Miyamoto, et al.
  • Journal Title: FEBS Lett Volume: 593 Pages: 423-432
  • DOI: 10.1002/1873-3468.13328
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Role of eosinophils in a murine model of inflammatory bowel disease. (2019)
  • Author(s): Wang Z, Adachi S, Kong L, Watanabe D, Nakanishi Y, Ohteki T, Hoshi N, Kodama Y.
  • Journal Title: Biochem Biophys Res Commun Volume: 511 Pages: 99-104
  • DOI: 10.1016/j.bbrc.2019.02.056
  • Peer Reviewed / Open Access
• [Journal Article] Transcriptome network analysis identifies protective role of the LXR/SREBP-1c axis in murine pulmonary fibrosis. (2019)
  • Author(s): Shichino S, Ueha S, Hashimoto S, Otsuji M, Abe J, Tsukui T, Deshimaru S, Nakajima T, Kosugi-Kanaya M, Shand FH, Inagaki Y, Shimano H, Matsushima K.
  • Journal Title: JCI Insight Volume: 4(1) Pages: 122163-122163
  • DOI: 10.1172/jci.insight.122163
  • Peer Reviewed / Open Access
• [Journal Article] Inhibition of HBV Transcription From cccDNA With Nitazoxanide by Targeting the HBx?DDB1 Interaction (2019)
  • Author(s): Sekiba Kazuma、Otsuka Motoyuki、Ohno Motoko、Yamagami Mari、Kishikawa Takahiro、Suzuki Tatsunori、Ishibashi Rei、Seimiya Takahiro、Tanaka Eri、Koike Kazuhiko
  • Journal Title: Cellular and Molecular Gastroenterology and Hepatology Volume: 7 Pages: 297-312
  • DOI: 10.1016/j.jcmgh.2018.10.010
  • Peer Reviewed / Open Access
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• [Journal Article] Endogenous Selenoprotein P, a Liver-Derived Secretory Protein, Mediates Myocardial Ischemia/Reperfusion Injury in Mice. (2018)
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• [Journal Article] Sirt2 facilitates hepatic glucose uptake by deacetylating glucokinase regulatory protein (2018)
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• [Journal Article] Asymmetric Integration of Single-Cell Transcriptomic Data using Latent Dirichlet Allocation and Procrustes Analysis (2018)
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• [Journal Article] Regnase-I controls colon epithelial regeneration via regulation of mTOR and purine metabolism. (2018)
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• [Journal Article] BATF2 activates DUSP2 gene expression and up-regulates NF-κB activity via phospho-STAT3 dephosphorylation (2018)
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  • DOI: 10.1016/j.bbrc.2018.10.050
  • Peer Reviewed
• [Journal Article] Mevalonate pathway blockage enhances the efficacy of mTOR inhibitors with the activation of retinoblastoma protein in renal cell carcinoma (2018)
  • Author(s): Hagiwara Nobuhisa、Watanabe Motoki、Iizuka-Ohashi Mahiro、Yokota Isao、Toriyama Seijiro、Sukeno Mamiko、Tomosugi Mitsuhiro、Sowa Yoshihiro、Hongo Fumiya、Mikami Kazuya、Soh Jintetsu、Fujito Akira、Miyashita Hiroaki、Morioka Yukako、Miki Tsuneharu、Ukimura Osamu、Sakai Toshiyuki
  • Journal Title: Cancer Lett. Volume: 431 Pages: 182-189
  • DOI: 10.1016/j.canlet.2018.05.025
  • Peer Reviewed
• [Journal Article] Blockage of the mevalonate pathway overcomes the apoptotic resistance to MEK inhibitors with suppressing the activation of Akt in cancer cells. (2018)
  • Author(s): Iizuka-Ohashi M1,2, Watanabe M1, Sukeno M1, Morita M1, Hoang NTH3, Kuchimaru T, Kizaka-Kondoh S, Sowa Y1 Sakaguchi K, Taguchi T, Sakai T.
  • Journal Title: Oncotarget Volume: 9 Pages: 19597-19612
  • DOI: 10.18632/oncotarget.24696
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Reinforce the antitumor activity of CD8+ T cells via glutamine restriction (2018)
  • Author(s): Nabe Shogo、Yamada Takeshi、Suzuki Junpei、Toriyama Koji、Yasuoka Toshiaki、Kuwahara Makoto、Shiraishi Atsushi、Takenaka Katsuto、Yasukawa Masaki、Yamashita Masakatsu
  • Journal Title: Cancer Sci. Volume: 109 Pages: 3737-3750
  • DOI: 10.1111/cas.13827
  • Peer Reviewed / Open Access
• [Journal Article] The tumor suppressor menin prevents effector CD8 T-cell dysfunction by targeting mTORC1-dependent metabolic activation (2018)
  • Author(s): Suzuki Junpei、Yamada Takeshi、Inoue Kazuki、Nabe Shogo、Kuwahara Makoto、Takemori Nobuaki、Takemori Ayako、Matsuda Seiji、Kanoh Makoto、Imai Yuuki、Yasukawa Masaki、Yamashita Masakatsu
  • Journal Title: Nat Commun. Volume: 9 Pages: 1-12
  • DOI: 10.1038/s41467-018-05854-6
  • Peer Reviewed / Open Access
• [Journal Article] Three-step transcriptional priming that drives the commitment of multipotent progenitors toward B cells (2018)
  • Author(s): Miyai Tomohiro、Takano Junichiro、Endo Takaho A.、Kawakami Eiryo、Agata Yasutoshi、Motomura Yasutaka、Kubo Masato、Kashima Yukie、Suzuki Yutaka、Kawamoto Hiroshi、Ikawa Tomokatsu
  • Journal Title: Genes Dev Volume: 32 Pages: 112-126
  • DOI: 10.1101/gad.309575.117
  • Peer Reviewed / Open Access
• [Journal Article] GITR cosignal in ILC2s controls allergic lung inflammation. (2018)
  • Author(s): Nagashima H, Okuyama Y, Fujita T, Takeda T, Motomura Y, Moro K, Hidaka T, Omori K, Sakurai T, Machiyama T, Ndhlovu LC, Riccardi C, So T, Ishii N.
  • Journal Title: Journal of Allergy and Clinical Immunology Volume: -
  • DOI: 10.1016/j.jaci.2018.01.028
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Proteomics analysis identified peroxiredoxin 2 involved in early-phase left ventricular impairment in hamsters with cardiomyopathy. (2018)
  • Author(s): Kuzuya K, Ichihara S, Suzuki Y, Inoue C, Ichihara G, Kurimoto S, Oikawa S.
  • Journal Title: Plos One Volume: 13
  • DOI: 10.1371/journal.pone.0192624
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] The DNA methylation profile of liver tumors in C3H mice and identification of differentially methylated regions involved in the regulation of tumorigenic genes. (2018)
  • Author(s): Matsushita J, Okamura K, Nakabayashi K, Suzuki T, Horibe Y, Kawai T, Sakurai T, Yamashita S, Higami Y, Ichihara G, Hata K, Nohara K
  • Journal Title: BMC Cancer Volume: 18 Pages: 317-317
  • DOI: 10.1186/s12885-018-4221-0
  • Peer Reviewed / Open Access
• [Journal Article] Pulmonary hypofunction due to calcium carbonate nanomaterial exposure in occupational workers: a cross-sectional study (2018)
  • Author(s): Li Guoliang、Liang Lihong、Yang Jingchao、Zeng Lihai、Xie Zhiwei、Zhong Yizhou、Ruan Xiaolin、Dong Ming、Yang Zhanhong、Lai Guanchao、Huang Weixin、Yang Aichu、Chen Jiabing、Wu Banghua、Xu Huaming、Meng Dezhi、Hu Shijie、Xia Lihua、Yang Xingfen、Li Laiyu、Ichihara Sahoko、Ichihara Gaku、Huang Hanlin、Huang Zhenlie
  • Journal Title: Nanotoxicology Volume: 12 Pages: 571-585
  • DOI: 10.1080/17435390.2018.1465606
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Exposure to 1,2-Dichloropropane Upregulates the Expression of Activation-Induced Cytidine Deaminase (AID) in Human Cholangiocytes Co-Cultured With Macrophages (2018)
  • Author(s): Zong Cai、Kimura Yusuke、Kinoshita Kazuo、Takasu Shigetada、Zhang Xiao、Sakurai Toshihiro、Sekido Yoshitaka、Ichihara Sahoko、Endo Ginji、Ichihara Gaku
  • Journal Title: Toxicological Sciences Volume: 168 Pages: 137-148
  • DOI: 10.1093/toxsci/kfy280
  • Peer Reviewed
• [Journal Article] Occupational Exposure Limits for ethylidene norbornene, ethyleneimine, benomyl, and 2,3-epoxypropyl methacrylate, and classifications on carcinogenicity (2018)
  • Author(s): Committee for Recommendation of Occupational Exposure Limits, Japan Society for Occupational Health, Araki A, Azuma K, Endo G, Endo Y, Fukushima T, Hara K, Hori H, Horie S, Horiguchi H, Ichiba M, Ichihara G, Ikeda M, Ishitake T, Ito A, Ito Y, Iwasawa S, Kakumu T, Kamijima M, Karita K.
  • Journal Title: J Occup Health Volume: 60 Issue: 4 Pages: 333-335
  • DOI: 10.1539/joh.2018-0137-op 10.1539/joh.2018-0137-OP
  • NAID: 130007403028
  • ISSN: 1341-9145, 1348-9585
  • Peer Reviewed / Open Access
• [Journal Article] Carcinogenicity of isobutyl nitrite, β-picoline, and some acrylates (2018)
  • Author(s): Kromhout H, Friesen M, Marques MM, Sergi CM, Abdallah M, Benke G, Cesta M, Germolec D, Houck K, Ichihara G, Jameson CW, Kanno J, Pogribny I, Svendsen C, Benbrahim-Tallaa L, Guyton KZ, Grosse Y, El Ghissassi F, Bouvard V, Hall A.
  • Journal Title: The Lancet Oncology Volume: 19 Pages: 1020-1022
  • DOI: 10.1016/s1470-2045(18)30491-1
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Familial episodic limb pain in kindreds with novel Nav1.9 mutations (2018)
  • Author(s): Kabata R, Okuda H, Noguchi A, Kondo D, Fujiwara M, Hata K, Kato Y, Ishikawa K, Tanaka M, Sekine Y, Hishikawa N, Mizukami T, Ito J, Akasaka M, Sakurai K, Yoshida T, Minoura H, Hayashi T, Inoshita K, Matsuyama M, Kinjo N, Cao Y, Inoue S, Kobayashi H, Harada KH, Youssefian S, Takahashi T, Koizumi A.
  • Journal Title: PLOS ONE Volume: 13
  • DOI: 10.1371/journal.pone.0208516
  • Peer Reviewed / Open Access
• [Journal Article] EXPRESS: Rare variants in RNF213, a susceptibility gene for moyamoya disease, are found in patients with pulmonary hypertension and aggravate hypoxia-induced pulmonary hypertension in mice (2018)
  • Author(s): Kobayashi Hatasu、Kabata Risako、Kinoshita Hideyuki、Morimoto Takaaki、Ono Koh、Takeda Midori、Choi Jungmi、Okuda Hiroko、Liu Wanyang、Harada Kouji H、Kimura Takeshi、Youssefian Shohab、Koizumi Akio
  • Journal Title: Pulmonary Circulation Volume: - Pages: 204589401877815-204589401877815
  • DOI: 10.1177/2045894018778155
  • Peer Reviewed / Open Access
• [Journal Article] Dysregulation of RNF213 promotes cerebral hypoperfusion (2018)
  • Author(s): Morimoto T, Enmi J, Hattori Y, Iguchi S, Saito S, Harada K, Okuda H, Mineharu Y, Takagi Y, Youssefian S, Iida H, Miyamoto S, Ihara M, Kobayashi H, Koizumi A.
  • Journal Title: Sci Rep. Volume: 8 Pages: 3607-3607
  • DOI: 10.1038/s41598-018-22064-8
  • NAID: 120006535057
  • Peer Reviewed / Open Access
• [Journal Article] β-cell-specific overexpression of adiponectin receptor 1 does not improve diabetes mellitus in Akita mice. (2018)
  • Author(s): Choi J, Kobayashi H, Okuda H, Harada KH, Takeda M, Fujimoto H, Yamane S, Tanaka D, Youssefian S, Inagaki N, Koizumi A.
  • Journal Title: PLOS ONE Volume: 13 (1)
  • DOI: 10.1371/journal.pone.0190863
  • NAID: 120006459971
  • Peer Reviewed / Open Access
• [Journal Article] Protein residue networks from energetic and geometric data ? are they identical? (2018)
  • Author(s): Vladimir Sladek, Hiroaki Tokiwa, Hitoshi Shimano, Yasuteru Shigeta
  • Journal Title: J Chem Theory Comput. Volume: 14(12) Pages: 6623-6631
  • DOI: 10.1021/acs.jctc.8b00733
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Network meta-analysis of the relative efficacy of bariatric surgeries for diabetes remission (2018)
  • Author(s): Kodama S.、Fujihara K.、Horikawa C.、Harada M.、Ishiguro H.、Kaneko M.、Furukawa K.、Matsubayashi Y.、Matsunaga S.、Shimano H.、Tanaka S.、Kato K.、Sone H.
  • Journal Title: Obesity Reviews Volume: 19 Pages: 1621-1629
  • DOI: 10.1111/obr.12751
  • Peer Reviewed
• [Journal Article] Relationship between intake of fruit separately from vegetables and triglycerides - A meta-analysis (2018)
  • Author(s): Kodama S, Horikawa C, Fujihara K, Ishii D, Hatta M, Takeda Y, Kitazawa M, Matsubayashi Y, Shimano H, Kato K, Tanaka S, Sone H
  • Journal Title: Clinical Nutrition ESPEN Volume: 27 Pages: 53-58
  • DOI: 10.1016/j.clnesp.2018.07.001
  • Peer Reviewed / Open Access
• [Journal Article] The Peroxisome Proliferator-Activated Receptor α (PPARα) Agonist Pemafibrate Protects against Diet-Induced Obesity in Mice (2018)
  • Author(s): Araki Masaya、Nakagawa Yoshimi、Oishi Asayo、Han Song-iee、Wang Yunong、Kumagai Kae、Ohno Hiroshi、Mizunoe Yuhei、Iwasaki Hitoshi、Sekiya Motohiro、Matsuzaka Takashi、Shimano Hitoshi
  • Journal Title: International journal of molecular sciences Volume: 19 Pages: 2148-2148
  • DOI: 10.3390/ijms19072148
  • NAID: 120006531296
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Brg1 regulates pro-lipogenic transcription by modulating SREBP activity in hepatocytes (2018)
  • Author(s): Li Nan、Li Min、Hong Wenxuan、Shao Jing、Xu Huihui、Shimano Hitoshi、Lu Jun、Xu Yong
  • Journal Title: Biochim Biophys Acta Mol Basis Dis. Volume: 1864 Pages: 2881-2889
  • DOI: 10.1016/j.bbadis.2018.05.022
  • Peer Reviewed
• [Journal Article] Malondialdehyde-modified LDL-related variables are associated with diabetic kidney disease in type 2 diabetes (2018)
  • Author(s): Furukawa Shoko、Suzuki Hiroaki、Fujihara Kazuya、Kobayashi Kazuto、Iwasaki Hitoshi、Sugano Yoko、Yatoh Shigeru、Sekiya Motohiro、Yahagi Naoya、Shimano Hitoshi
  • Journal Title: Diabetes Research and Clinical Practice Volume: 141 Pages: 237-243
  • DOI: 10.1016/j.diabres.2018.05.019
  • Peer Reviewed
• [Journal Article] CREBH Regulates Systemic Glucose and Lipid Metabolism (2018)
  • Author(s): Nakagawa Yoshimi、Shimano Hitoshi
  • Journal Title: Int J Mol Sci. Volume: 19 Pages: 1396-1396
  • DOI: 10.3390/ijms19051396
  • NAID: 120006501396
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Evaluation of safety for hepatectomy in a novel mouse model with nonalcoholic-steatohepatitis (2018)
  • Author(s): Ozawa Yusuke、Tamura Takafumi、Owada Yohei、Shimizu Yoshio、Kemmochi Akira、Hisakura Katsuji、Matsuzaka Takashi、Shimano Hitoshi、Isoda Hiroko、Ohkohchi Nobuhiro
  • Journal Title: World Journal of Gastroenterology Volume: 24 Pages: 1622-1631
  • DOI: 10.3748/wjg.v24.i15.1622
  • Peer Reviewed
• [Journal Article] Transgenic Mice Overexpressing SREBP-1a in Male ob/ob Mice Exhibit Lipodystrophy and Exacerbate Insulin Resistance. (2018)
  • Author(s): Ohno H, Matsuzaka T, Tang N, Sharma R, Motomura K, Shimura T, Satoh A, Han SI, Takeuchi Y, Aita Y, Iwasaki H, Yatoh S, Suzuki H, Sekiya M, Nakagawa Y, Sone H, Yahagi N, Yamada N, Higami Y, Shimano H.
  • Journal Title: Endocrinology Volume: 159(6) Pages: 2308-2323
  • DOI: 10.1210/en.2017-03179
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Molecular association model of PPARα and its new specific and efficient ligand, pemafibrate: Structural basis for SPPARMα (2018)
  • Author(s): Yamamoto Yuta、Takei Kenta、Arulmozhiraja Sundaram、Sladek Vladimir、Matsuo Naoya、Han Song-iee、Matsuzaka Takashi、Sekiya Motohiro、Tokiwa Takaki、Shoji Mitsuo、Shigeta Yasuteru、Nakagawa Yoshimi、Tokiwa Hiroaki、Shimano Hitoshi
  • Journal Title: Biochem Biophys Res Commun Volume: 499 Pages: 239-245
  • DOI: 10.1016/j.bbrc.2018.03.135
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Saturated Fatty Acids Undergo Intracellular Crystallization and Activate the NLRP3 Inflammasome in MacrophagesHighlights (2018)
  • Author(s): Karasawa Tadayoshi、Kawashima Akira、Usui-Kawanishi Fumitake、Watanabe Sachiko、Kimura Hiroaki、Kamata Ryo、Shirasuna Koumei、Koyama Yutaro、Sato-Tomita Ayana、Matsuzaka Takashi、Tomoda Hiroshi、Park Sam-Yong、Shibayama Naoya、Shimano Hitoshi、Kasahara Tadashi、Takahashi Masafumi
  • Journal Title: Arterioscler Thromb Vasc Biol. Volume: 38 Pages: 744-756
  • DOI: 10.1161/atvbaha.117.310581
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Epigenetic modulation of Fgf21 in the perinatal mouse liver ameliorates diet-induced obesity in adulthood (2018)
  • Author(s): X Yuan, K Tsujimoto, K Hashimoto, K Kawahori, N Hanzawa, M Hamaguchi, T Seki, M Nawa, T Ehara, Y Kitamura, I Hatada, M Konishi, N Itoh, Y Nakagawa, H Shimano, T Takai-Igarashi, Y Kamei, Y Ogawa.
  • Journal Title: Nat. Commun. Volume: 9 Pages: 636-636
  • DOI: 10.1038/s41467-018-03038-w
  • NAID: 120006454799
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Age-dependent changes in dynamic standing-balance ability evaluated quantitatively using a stabilometer (2018)
  • Author(s): Suzuki Yasuhiro、Yatoh Shigeru、Suzuki Hiroaki、Tanabe Yuuki、Shimizu Yukiyo、Hada Yasushi、Shimano Hitoshi
  • Journal Title: J Phys Ther Sci Volume: 30 Issue: 1 Pages: 86-91
  • DOI: 10.1589/jpts.30.86
  • NAID: 130006321186
  • ISSN: 0915-5287, 2187-5626
  • Peer Reviewed
• [Journal Article] A candidate functional SNP rs7074440 in TCF7L2 alters gene expression through C-FOS in hepatocytes. (2018)
  • Author(s): Piao X, Yahagi N, Takeuchi Y, Aita Y, Murayama Y, Sawada Y, Shikama A, Masuda Y, Nishi-Tatsumi M, Kubota M, Izumida Y, Sekiya M, Matsuzaka T, Nakagawa Y, Sugano Y, Iwasaki H, Kobayashi K, Yatoh S, Suzuki H, Yagyu H, Kawakami Y, Shimano H.
  • Journal Title: FEBS Letters Volume: 592(3) Pages: 422-433
  • DOI: 10.1002/1873-3468.12975
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] A Rare Coexistence of Pheochromocytoma and Parkinson's Disease With Diagnostic Challenges (2018)
  • Author(s): Matsumura-Matsuda Erika、Sekiya Motohiro、Omoto-Inuzuka Miyoko、Santo Kana、Shikama Akito、Kuba Motoko、Sugano Yoko、Iwasaki Hitoshi、Yatoh Shigeru、Sato Taiki、Hara Hisato、Takekoshi Kazuhiro、Suzuki Hiroaki、Shimano Hitoshi
  • Journal Title: Intern. Med. Volume: 57 Issue: 7 Pages: 979-985
  • DOI: 10.2169/internalmedicine.9242-17
  • NAID: 130006602591
  • ISSN: 0918-2918, 1349-7235
  • Peer Reviewed
• [Journal Article] Relationships among cardiorespiratory fitness, muscular fitness, and cardiometabolic risk factors in Japanese adolescents: Niigata screening for and preventing the development of non-communicable disease study-Agano (NICE EVIDENCE Study-Agano) 2. (2018)
  • Author(s): Morikawa SY, Fujihara K, Hatta M, Osawa T, Ishizawa M, Yamamoto M, Furukawa K, Ishiguro H, Matsunaga S, Ogawa Y, Shimano H, Sone H.
  • Journal Title: Pediatric Diabetes Volume: 印刷中 Pages: 593-602
  • DOI: 10.1111/pedi.12623
  • Peer Reviewed / Open Access
• [Journal Article] Monopoiesis in humans and mice (2018)
  • Author(s): Kawamura Shunsuke、Ohteki Toshiaki
  • Journal Title: International Immunology Volume: 30 Pages: 503-509
  • DOI: 10.1093/intimm/dxy063
  • Peer Reviewed
• [Journal Article] IFN-γ-dependent epigenetic regulation instructs colitogenic monocyte/macrophage lineage differentiation in vivo. (2018)
  • Author(s): Nakanishi Y, Sato T, Takahashi K, Ohteki T.
  • Journal Title: Mucosal Immunology Volume: - Pages: 871-880
  • DOI: 10.1038/mi.2017.104
  • Peer Reviewed
• [Journal Article] Macrophages in inflammation, repair and regeneration (2018)
  • Author(s): Oishi Y, Manabe I
  • Journal Title: International Immunology Volume: 30 Pages: 511-528
  • DOI: 10.1093/intimm/dxy054
  • Peer Reviewed / Open Access
• [Journal Article] Does the prenatal bisphenol A exposure alter DNA methylation levels in the mouse hippocampus?: An analysis using a high-sensitivity methylome technique (2018)
  • Author(s): Aiba Toshiki、Saito Toshiyuki、Hayashi Akiko、Sato Shinji、Yunokawa Harunobu、Maruyama Toru、Fujibuchi Wataru、Ohsako Seiichiroh
  • Journal Title: Genes and Environment Volume: 40 Pages: 12-12
  • DOI: 10.1186/s41021-018-0099-y
  • Peer Reviewed
• [Journal Article] Detection of dioxin-induced demethylation of mouse Cyp1a1 gene promoter by a new labeling method for short DNA fragments possessing 5'-methylcytosine at the end (2018)
  • Author(s): Kurita Hisaka、Aiba Toshiki、Saito Toshiyuki、Ohsako Seiichiroh
  • Journal Title: Genes and Environment Volume: 40 Pages: 1-1
  • DOI: 10.1186/s41021-017-0089-5
  • Peer Reviewed / Open Access
• [Journal Article] Expression of xenobiotic biomarkers CYP1 family in preputial tissue of patients with hypospadias and phimosis and its association with DNA methylation level of SRD5A2 minimal promoter. (2018)
  • Author(s): Ohsako S, Aiba T, Miyado M, Fukami M, Ogata T, Hayashi Y, Mizuno K and Kojima Y.
  • Journal Title: Arch Environ Contam Toxicol Volume: 74 Pages: 240-247
  • DOI: 10.1007/s00244-017-0466-x
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Lung fibroblasts express a miR-19a-19b-20a sub-cluster to suppress TGF-β-associated fibroblast activation in murine pulmonary fibrosis (2018)
  • Author(s): Souma Kunihiko、Shichino Shigeyuki、Hashimoto Shinichi、Ueha Satoshi、Tsukui Tatsuya、Nakajima Takuya、Suzuki Hiroshi I.、Shand Francis H. W.、Inagaki Yutaka、Nagase Takahide、Matsushima Kouji
  • Journal Title: Scientific Reports Volume: 8 Pages: 1-14
  • DOI: 10.1038/s41598-018-34839-0
  • Peer Reviewed / Open Access
• [Journal Article] STAM-binding protein regulates melanoma metastasis through SLUG stabilization. (2018)
  • Author(s): Iwakami Y, Yokoyama S, Watanabe K, Hayakawa Y.
  • Journal Title: Biochemical and Biophysical Research Communications Volume: 507 Pages: 484-488
  • DOI: 10.1016/j.bbrc.2018.11.068
  • Peer Reviewed / Open Access
• [Journal Article] Lung-resident natural killer cells control pulmonary tumor growth in mice (2018)
  • Author(s): Yamamoto Yutaka、Miyazato Kiho、Takahashi Kei、Yoshimura Naoki、Tahara Hideaki、Hayakawa Yoshihiro
  • Journal Title: Cancer Sci. Volume: 109 Pages: 2670-2676
  • DOI: 10.1111/cas.13703
  • Peer Reviewed / Open Access
• [Journal Article] A Gata3 3′ Distal Otic Vesicle Enhancer Directs Inner Ear-Specific Gata3 Expression (2018)
  • Author(s): Moriguchi Takashi、Hoshino Tomofumi、Rao Arvind、Yu Lei、Takai Jun、Uemura Satoshi、Ise Kazue、Nakamura Yasuhiro、Lim Kim-Chew、Shimizu Ritsuko、Yamamoto Masayuki、Engel James Douglas
  • Journal Title: Mol Cell Biol. Volume: 38 Pages: 21-21
  • DOI: 10.1128/mcb.00302-18
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Satellite RNA Increases DNA Damage and Accelerates Tumor Formation in Mouse Models of Pancreatic Cancer (2018)
  • Author(s): Kishikawa Takahiro、Otsuka Motoyuki、Suzuki Tatsunori、Seimiya Takahiro、Sekiba Kazuma、Ishibashi Rei、Tanaka Eri、Ohno Motoko、Yamagami Mari、Koike Kazuhiko
  • Journal Title: Molecular Cancer Research Volume: 16 Pages: 1255-1262
  • DOI: 10.1158/1541-7786.mcr-18-0139
  • Peer Reviewed / Open Access
• [Journal Article] MicroRNA-7: a potent suppressor of the malignant potential of hepatocellular carcinoma (2018)
  • Author(s): Otsuka Motoyuki、Tanaka Eri、Sekiba Kazuma、Seimiya Takahiro、Yamagami Mari、Koike Kazuhiko
  • Journal Title: Non-coding RNA Investigation Volume: 2 Pages: 30-30
  • DOI: 10.21037/ncri.2018.05.04
  • Peer Reviewed
• [Journal Article] Hepatitis B virus pathogenesis: Fresh insights into hepatitis B virus RNA (2018)
  • Author(s): Sekiba Kazuma、Otsuka Motoyuki、Ohno Motoko、Yamagami Mari、Kishikawa Takahiro、Suzuki Tatsunori、Ishibashi Rei、Seimiya Takahiro、Tanaka Eri、Koike Kazuhiko
  • Journal Title: World Journal of Gastroenterology Volume: 24 Pages: 2261-2268
  • DOI: 10.3748/wjg.v24.i21.2261
  • Peer Reviewed / Open Access
• [Journal Article] DHX9 regulates production of hepatitis B virus-derived circular RNA and viral protein levels (2018)
  • Author(s): Sekiba Kazuma、Otsuka Motoyuki、Ohno Motoko、Kishikawa Takahiro、Yamagami Mari、Suzuki Tatsunori、Ishibashi Rei、Seimiya Takahiro、Tanaka Eri、Koike Kazuhiko
  • Journal Title: Oncotarget Volume: 9 Pages: 20953-20964
  • DOI: 10.18632/oncotarget.25104
  • Peer Reviewed / Open Access
• [Journal Article] Production of low-molecular weight soluble yeast β-glucans by an acid degradation method. (2018)
  • Author(s): Ishimoto, Y., Ishibashi, K. I., Yamanaka, D., Adachi, Y., Kanzaki, K., Iwakura, Y., and Ohno, N.
  • Journal Title: Mucosal Immunol Volume: 107 Pages: 2269-2278
  • DOI: 10.1038/mi.2017.86
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Suppression of IL-17F, but not of IL-17A, provides protection against colitis by inducing T(reg) cells through modification of the intestinal microbiota. (2018)
  • Author(s): Tang C, Kakuta S, Shimizu K, Kadoki M, Kamiya T, Shimazu T, Kubo S, Saijo S, Ishigame H, Nakae S, Iwakura Y.
  • Journal Title: Nature immunology Volume: 19 Pages: 755-765
  • DOI: 10.1038/s41590-018-0134-y
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Effects of high fructose intake on liver injury progression in high fat diet induced fatty liver disease in ovariectomized female mice (2018)
  • Author(s): Ohashi Tomoko、Kato Masaki、Yamasaki Akihiro、Kuwano Akifumi、Suzuki Hideo、Kohjima Motoyuki、Ogawa Yoshihiro
  • Journal Title: Food Chem. Toxicol. Volume: 118 Pages: 190-197
  • DOI: 10.1016/j.fct.2018.05.006
  • Peer Reviewed
• [Journal Article] Obeticholic acid protects against hepatocyte death and liver fibrosis in a murine model of nonalcoholic steatohepatitis. (2018)
  • Author(s): T. Goto, M. Itoh, T. Suganami, S. Kanai, I. Shirakawa, T. Sakai, M. Asakawa,T. Yoneyama, T. Kai, Y. Ogawa.
  • Journal Title: Sci Rep. Volume: 8 Pages: 8157-8157
  • DOI: 10.1038/s41598-018-26383-8
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Efficient identification of compounds suppressing protein precipitation via solvent screening using serial deletion mutants of the target protein (2018)
  • Author(s): Yunoki Kaori、Yoshinaga Sosuke、Takeda Mitsuhiro、Nagano Ryohei、Tsuchiya Yusuke、Sonoda Akihiro、Tsuji Tatsuichiro、Hirakane Makoto、Toda Etsuko、Terashima Yuya、Matsushima Kouji、Terasawa Hiroaki
  • Journal Title: Genes to Cells Volume: 23 Pages: 70-79
  • DOI: 10.1111/gtc.12554
  • Peer Reviewed
• [Journal Article] Single blood transfusion induces the production of donor-specific alloantibodies and regulatory T cells mainly in the spleen. (2018)
  • Author(s): Ueta H, Kitazawa Y, Sawanobori Y, Ueno T, Ueha S, Matsushima K, Matsuno K.
  • Journal Title: International Immunology Volume: 30 Pages: 53-67
  • DOI: 10.1093/intimm/dxx078
  • Peer Reviewed / Open Access
• [Journal Article] Increased diversity with reduced "diversity evenness" of tumor infiltrating T-cells for the successful cancer immunotherapy. (2018)
  • Author(s): Hosoi A, Takeda K, Nagaoka K, Iino T, Matsushita H, Ueha S, Aoki S, Matsushima K, Kubo M, Morikawa T, Kitaura K, Suzuki R, Kakimi K.
  • Journal Title: SCIENITIFIC REPORTS. Volume: 8 Pages: 1058-1058
  • DOI: 10.1038/s41598-018-19548-y
  • Peer Reviewed / Open Access
• [Journal Article] NK Cells Control Tumor-Promoting Function of Neutrophils in Mice (2018)
  • Author(s): Ogura K, Sato-Matsushita M, Yamamoto S, Hori T, Sasahara M, Iwakura Y, Saiki I, Tahara H, Hayakawa Y
  • Journal Title: Cancer immunology research Volume: 印刷中 Pages: 348-357
  • DOI: 10.1158/2326-6066.cir-17-0204
  • NAID: 120006402039
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Single blood transfusion induces the production of donor-specific alloantibodies and regulatory T cells mainly in the spleen. (2018)
  • Author(s): Ueta H, Kitazawa Y, Sawanobori Y, Ueno T, Ueha S, Matsushima K, Matsuno K.
  • Journal Title: Int Immunol Volume: 8 Pages: 53-67
  • Peer Reviewed / Open Access
• [Journal Article] Dysregulation of RNF213 promotes cerebral hypoperfusion. (2018)
  • Author(s): Morimoto T, Enmi JI, Hattori Y, Iguchi S, Saito S, Harada KH, Okuda H, Mineharu Y, Takagi Y, Youssefian S, Iida H, Miyamoto S, Ihara M, Kobayashi H, Koizumi A.
  • Journal Title: Sci Rep Volume: 26 Pages: 3607-3607
  • Peer Reviewed / Open Access
• [Journal Article] Correction to Synthesis of Potent and Selective Inhibitors of Aldo-Keto Reductase 1B10 and Their Efficacy against Proliferation, Metastasis, and Cisplatin Resistance of Lung Cancer Cells. (2018)
  • Author(s): Endo S, Xia S, Suyama M, Morikawa Y, Oguri H, Hu D, Ao Y, Takahara S, Horino Y, Hayakawa Y, Watanabe Y, Gouda H, Hara A, Kuwata K, Toyooka N, Matsunaga T, Ikari A.
  • Journal Title: J Med Chem Volume: 8 Pages: 1380-1380
  • Peer Reviewed / Open Access
• [Journal Article] Expression of Xenobiotic Biomarkers CYP1 Family in Preputial Tissue of Patients with Hypospadias and Phimosis and Its Association with DNA Methylation Level of SRD5A2 Minimal Promoter. (2018)
  • Author(s): Ohsako S, Aiba T, Miyado M, Fukami M, Ogata T, Hayashi Y, Mizuno K, Kojima Y.
  • Journal Title: Arch Environ Contam Toxicol Volume: 74(2) Pages: 240-247
  • Peer Reviewed / Open Access
• [Journal Article] Efficient identification of compounds suppressing protein precipitation via solvent screening using serial deletion mutants of the target protein. (2018)
  • Author(s): Yunoki K, Yoshinaga S, Takeda M, Nagano R, Tsuchiya Y, Sonoda A, Tsuji T, Hirakane M, Toda E, Terashima Y, Matsushima K, Terasawa H.
  • Journal Title: Genes Cells Volume: 23(2) Pages: 70-79
  • Peer Reviewed / Open Access
• [Journal Article] NK Cells Control Tumor-Promoting Function of Neutrophils in Mice. (2018)
  • Author(s): Ogura K, Sato-Matsushita M, Yamamoto S, Hori T, Sasahara M, Iwakura Y, Saiki I, Tahara H, Hayakawa Y.
  • Journal Title: Cancer Immunol Res Volume: 23
  • Peer Reviewed / Open Access
• [Journal Article] Increased diversity with reduced "diversity evenness" of tumor infiltrating T-cells for the successful cancer immunotherapy. (2018)
  • Author(s): Hosoi A, Takeda K, Nagaoka K, Iino T, Matsushita H, Ueha S, Aoki S, Matsushima K, Kubo M, Morikawa T, Kitaura K, Suzuki R, Kakimi K.
  • Journal Title: Sci Rep Volume: 18 Pages: 1058-1058
  • Peer Reviewed / Open Access
• [Journal Article] The Dark Side of IFN-g: Its Role in Promoting Cancer Immunoevasion. (2017)
  • Author(s): Mojic M, Takeda K, Hayakawa Y.
  • Journal Title: Int J Mol Sci Volume: 28 Pages: 1-13
  • DOI: 10.3390/ijms19010089
  • Peer Reviewed / Open Access
• [Journal Article] Long-Lasting Graft-Derived Donor T Cells Contribute to the Pathogenesis of Chronic Graft-versus-Host Disease in Mice. (2017)
  • Author(s): Kosugi-Kanaya M, Ueha S, Abe J, Shichino S, Shand FHW, Morikawa T, Kurachi M, Shono Y, Sudo N, Yamashita A, Suenaga F, Yokoyama A, Yong W, Imamura M, Teshima T, Matsushima K.
  • Journal Title: Front Immunol Volume: 18 Pages: 1-14
  • Peer Reviewed / Open Access
• [Journal Article] ASK1 facilitates tumor metastasis through phosphorylation of an ADP receptor P2Y(12) in platelets. (2017)
  • Author(s): Kamiyama M, Shirai T, Tamura S, Suzuki-Inoue K, Ehata S, Takahashi K, Miyazono K, Hayakawa Y, Sato T, Takeda K, Naguro I, Ichijo H.
  • Journal Title: Cell Death Differ Volume: 24(12) Pages: 2066-2076
  • Peer Reviewed
• [Journal Article] The CD45(+) fraction in murine adipose tissue derived stromal cells harbors immune-inhibitory inflammatory cells. (2017)
  • Author(s): Nasti A, Sakai Y, Seki A, Buffa GB, Komura T, Mochida H, Yamato M, Yoshida K, Ho TTB, Takamura M, Usui S, Wada T, Honda M, Kaneko S.
  • Journal Title: Eur J Immunol Volume: 47(12) Pages: 2163-2174
  • Peer Reviewed
• [Journal Article] Effect of sodium-glucose cotransporter 2 (SGLT2) inhibition on weight loss is partly mediated by liver-brain-adipose neurocircuitry. (2017)
  • Author(s): Sawada Y, Izumida Y, Takeuchi Y, Aita Y, Wada N, Li E, Murayama Y, Piao X, Shikama A, Masuda Y, Nishi-Tatsumi M, Kubota M, Sekiya M, Matsuzaka T, Nakagawa Y, Sugano Y, Iwasaki H, Kobayashi K, Yatoh S, Suzuki H, Yagyu H, Kawakami Y, et al.
  • Journal Title: Biochem Biophys Res Commun Volume: 4 Pages: 40-45
  • Peer Reviewed
• [Journal Article] Ribosomal protein S3 regulates XIAP expression independently of the NF-ホコB pathway in breast cancer cells. (2017)
  • Author(s): Ono H, Iizumi Y, Goi W, Sowa Y, Taguchi T, Sakai T.
  • Journal Title: Oncol Rep Volume: 38(5) Pages: 3205-3210
  • Peer Reviewed
• [Journal Article] Report of the International Stem Cell Banking Initiative Workshop Activity: Current Hurdles and Progress in Seed-Stock Banking of Human Pluripotent Stem Cells. (2017)
  • Author(s): Kim JH, Kurtz A, Yuan BZ, Zeng F, Lomax G, Loring JF, Crook J, Ju JH, Clarke L, Inamdar MS, Pera M, Firpo MT, Sheldon M, Rahman N, O'Shea O, Pranke P, Zhou Q, Isasi R, Rungsiwiwut R, Kawamata S, Oh S, Ludwig T, et al.
  • Journal Title: Stem Cells Transl Med Volume: 6(11) Pages: 1956-1962
  • Peer Reviewed
• [Journal Article] Comprehensive single-cell transcriptome analysis reveals heterogeneity in endometrioid adenocarcinoma tissues. (2017)
  • Author(s): Hashimoto S, Tabuchi Y, Yurino H, Hirohashi Y, Deshimaru S, Asano T, Mariya T, Oshima K, Takamura Y, Ukita Y, Ametani A, Kondo N, Monma N, Takeda T, Misu S, Okayama T, Ikeo K, Saito T, Kaneko S, Suzuki Y, Hattori M, Matsushima K, et al.
  • Journal Title: Sci Rep Volume: 27 Pages: 14225-14225
  • Peer Reviewed / Open Access
• [Journal Article] Gene expression profiling of hepatocarcinogenesis in a mouse model of chronic hepatitis B. (2017)
  • Author(s): Nosaka T, Naito T, Hiramatsu K, Ohtani M, Nemoto T, Marusawa H, Ma N, Hiraku Y, Kawanishi S, Yamashita T, Kaneko S, Nakamoto Y.
  • Journal Title: PLoS One Volume: 2
  • Peer Reviewed / Open Access
• [Journal Article] Combination of anti-CD4 antibody treatment and donor lymphocyte infusion ameliorates graft-versus-host disease while preserving graft-versus-tumor effects in murine allogeneic hematopoietic stem cell transplantation. (2017)
  • Author(s): Ueha S, Yokochi S, Ishiwata Y, Kosugi-Kanaya M, Shono Y, Shibayama S, Ito S, Matsushima K.
  • Journal Title: Cancer Sci Volume: 108(10) Pages: 1967-1973
  • Peer Reviewed / Open Access
• [Journal Article] Long non-coding RNA HOTAIR promotes cell migration by upregulating insulin growth factor-binding protein 2 in renal cell carcinoma. (2017)
  • Author(s): Katayama H, Tamai K, Shibuya R, Nakamura M, Mochizuki M, Yamaguchi K, Kawamura S, Tochigi T, Sato I, Okanishi T, Sakurai K, Fujibuchi W, Arai Y, Satoh K.
  • Journal Title: Sci Rep Volume: 20 Pages: 12016-12016
  • NAID: 120006364089
  • Peer Reviewed / Open Access
• [Journal Article] Proteasome Inhibitor-Loaded Micelles Enhance Antitumor Activity Through Macrophage Reprogramming by NF-ホコB Inhibition. (2017)
  • Author(s): Wu H, Tao A, Martin JD, Quader S, Liu X, Takahashi K, Hespel L, Miura Y, Hayakawa Y, Irimura T, Cabral H, Kataoka K.
  • Journal Title: J Pharm Sci Volume: 106(9) Pages: 2438-2446
  • Peer Reviewed
• [Journal Article] Optimized retroviral transduction of mouse T cells for in vivo assessment of gene function. (2017)
  • Author(s): Kurachi M, Kurachi J, Chen Z, Johnson J, Khan O, Bengsch B, Stelekati E, Attanasio J, McLane LM, Tomura M, Ueha S, Wherry EJ.
  • Journal Title: Nat Protoc Volume: 12(9) Pages: 1980-1998
  • Peer Reviewed
• [Journal Article] RNF213 p.R4810K Variant and Intracranial Arterial Stenosis or Occlusion in Relatives of Patients with Moyamoya Disease. (2017)
  • Author(s): Matsuda Y, Mineharu Y, Kimura M, Takagi Y, Kobayashi H, Hitomi T, Harada KH, Uchihashi Y, Funaki T, Miyamoto S, Koizumi A.
  • Journal Title: J Stroke Cerebrovasc Dis Volume: 26(8) Pages: 1841-1847
  • Peer Reviewed
• [Journal Article] Occupational exposure limits for ethylene glycol monobutyl ether, isoprene, isopropyl acetate and propyleneimine, and classifications on carcinogenicity, occupational sensitizer and reproductive toxicant. (2017)
  • Author(s): Committee for Recommendation of Occupational Exposure Limits, Japan Society for Occupational Health., Azuma K, Endo G, Endo Y, Fukushima T, Hara K, Hori H, Horie S, Horiguchi H, Ichiba M, Ichihara G, Ikeda M, Ishitake T, Ito A, Ito Y, Iwasawa S, Kamijima M, Karita K, Katoh T, Kawai T, Kawamoto T, Kishi R, et al.
  • Journal Title: J Occup Health Volume: 27 Pages: 364-366
  • Peer Reviewed
• [Journal Article] Elovl6 Deficiency Improves Glycemic Control in Diabetic db/db Mice by Expanding ホイ-Cell Mass and Increasing Insulin Secretory Capacity. (2017)
  • Author(s): Zhao H, Matsuzaka T, Nakano Y, Motomura K, Tang N, Yokoo T, Okajima Y, Han SI, Takeuchi Y, Aita Y, Iwasaki H, Yatoh S, Suzuki H, Sekiya M, Yahagi N, Nakagawa Y, Sone H, Yamada N, Shimano H.
  • Journal Title: Diabetes Volume: 66(7) Pages: 1833-1846
  • Peer Reviewed
• [Journal Article] CoptidisツRhizoma induces intrinsic apoptosis through BAX and BAK activation in human melanoma. (2017)
  • Author(s): Xu X, Yokoyama S, Hayakawa Y, Saiki I.
  • Journal Title: Oncol Rep Volume: 38(1) Pages: 538-544
  • Peer Reviewed / Open Access
• [Journal Article] Microarray analyses of otospheres derived from the cochlea in the inner ear identify putative transcription factors that regulate the characteristics of otospheres. (2017)
  • Author(s): Iki T, Tanaka M, Kitajiri SI, Kita T, Kawasaki Y, Mizukoshi A, Fujibuchi W, Nakagawa T, Nakahata T, Ito J, Omori K, Saito MK.
  • Journal Title: PLoS One Volume: 12(6)
  • Peer Reviewed / Open Access
• [Remarks] 予防を科学する炎症細胞社会学ホームページ
  • URL: http://inflammationcellularsociology.org/
• [Remarks] 新学術領域研究 予防を科学する炎症細胞社会学 ホームページ
  • URL: http://inflammationcellularsociology.org/
• [Funded Workshop] 文部科学省新学術領域研究 予防を科学する炎症細胞社会学 1st International Symposium on Inflammation Cellular Sociology（第1回国際シンポジウム） (2019)