Preventive medicine through inflammation cellular sociology

• Project Area: Preventive medicine through inflammation cellular sociology
• Project/Area Number: 17H06391
• Research Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
• Allocation Type: Single-year Grants
• Review Section: Complex systems
• Research Institution: Tokyo University of Science (2018-2021); The University of Tokyo (2017)
• Principal Investigator: Matsushima Kouji 東京理科大学, 研究推進機構生命医科学研究所, 教授 (50222427)
• Co-Investigator(Kenkyū-buntansha): 橋本 真一 和歌山県立医科大学, 先端医学研究所, 教授 (00313099) ; 藤渕 航 京都大学, iPS細胞研究所, 教授 (60273512)
• Project Period (FY): 2017-06-30 – 2022-03-31
• Project Status: Completed (Fiscal Year 2021)
• Budget Amount: ¥196,560,000 (Direct Cost: ¥151,200,000、Indirect Cost: ¥45,360,000); Fiscal Year 2021: ¥33,150,000 (Direct Cost: ¥25,500,000、Indirect Cost: ¥7,650,000); Fiscal Year 2020: ¥33,150,000 (Direct Cost: ¥25,500,000、Indirect Cost: ¥7,650,000); Fiscal Year 2019: ¥33,150,000 (Direct Cost: ¥25,500,000、Indirect Cost: ¥7,650,000); Fiscal Year 2018: ¥33,150,000 (Direct Cost: ¥25,500,000、Indirect Cost: ¥7,650,000); Fiscal Year 2017: ¥63,960,000 (Direct Cost: ¥49,200,000、Indirect Cost: ¥14,760,000)
• Keywords: 免疫 / 遺伝子 / 情報工学 / モデル化 / 病理学

Outline of Final Research Achievements

The Center for the analysis of Cellular Society of Inflammation, which supports scRNA-seq, various omics analyses, and information analysis, was set up under the General Affairs Group to support each planned and publicly research project. By using the standardized and optimized cell preparation technology of the project leaders and the highly sensitive and accurate scRNA-seq technology developed originally by the project leaders as the common basic technology for the project, a disease scRNA-seq database was constructed to enable cross-sectional data comparison across diseases and organs. We have also established a novel information analysis technology for biological interpretation of these data. Various target cells and molecules that could lead to the prevention and treatment of individual diseases have been obtained, and are expected to be applied to clinical development and disease prevention and treatment in the future.

Academic Significance and Societal Importance of the Research Achievements

肺、肝臓、腎臓、膵臓、腸管、皮膚などの疾患モデル、臨床検体について、サンプル調製からデータ解析までの工程を標準化したscRNA-seqデータを横断的に集積した炎症細胞社会データベースは、今後の疾患研究と創薬、そして予防戦略の構築に大きく貢献すると期待している。また、肺線維症における、病的C1q+ マクロファージやアミノ酸トランスポーター関連分子とその制御による線維化予防、2型糖尿病の未病状態特異的マーカーの同定、肝線維化診断マーカーの同定、慢性腎障害の予防剤、老化細胞除去剤、脳障害に対する保護剤などが見いだされており、今後の臨床開発への進展、疾患予防・治療への応用が期待される。

Research Products

• [Journal Article] Profibrotic properties of C1q+ interstitial macrophages in silica-induced pulmonary fibrosis in mice. (2022)
  • Author(s): Ogawa T, Shichino S, Ueha S, Bando K, Matsushima K.
  • Journal Title: Biochem Biophys Res Commun. Volume: 599 Pages: 113-119
  • DOI: 10.1016/j.bbrc.2022.02.037
  • Peer Reviewed / Open Access
• [Journal Article] Complement protein C1q activates lung fibroblasts and exacerbates silica-induced pulmonary fibrosis in mice. (2022)
  • Author(s): Ogawa T, Shichino S, Ueha S, Ogawa S, Matsushima K.
  • Journal Title: Biochem Biophys Res Commun. Volume: 603 Pages: 88-93
  • DOI: 10.1016/j.bbrc.2022.02.090
  • Peer Reviewed / Open Access
• [Journal Article] Revealing Clonal Responses of Tumor-Reactive T-Cells Through T Cell Receptor Repertoire Analysis. (2022)
  • Author(s): Aoki H, Shichino S, Matsushima K, Ueha S.
  • Journal Title: Front Immunol. Volume: 13 Pages: 807696-807696
  • DOI: 10.3389/fimmu.2022.807696
  • Peer Reviewed / Open Access
• [Journal Article] Intestinal Bacterial Translocation Contributes to Diabetic Kidney Disease. (2022)
  • Author(s): Linh HT, Iwata Y, Senda Y, Sakai-Takemori Y, Nakade Y, Oshima M, Nakagawa-Yoneda S, Ogura H, Sato K, Minami T, Kitajima S, Toyama T, Yamamura Y, Miyagawa T, Hara A, Shimizu M, Furuichi K, Sakai N, Yamada H, Asanuma K, Matsushima K, Wada T.
  • Journal Title: J Am Soc Nephrol. Volume: - Pages: -
  • DOI: 10.1681/ASN.2021060843
  • Peer Reviewed / Open Access
• [Journal Article] Rare toxin A-negative and toxin B-positive strain of Clostridioides difficile from Japan lacking a complete tcdA gene. (2022)
  • Author(s): Takemori-Sakai Y, Satou K, Senda Y, Nakamura Y, Otani H, Maekawa A, Oe H, Oshima M, Yoneda-Nakagawa S, Miyagawa T, Sato K, Ogura H, Mori M, Wada T, Sakai Y, Yutani M, Matsumura T, Fujinaga Y, Gabata T, Wada T, Iwata Y.
  • Journal Title: J Infect Chemother. Volume: 28 Pages: 651-656
  • DOI: 10.1016/j.jiac.2022.01.015
  • Peer Reviewed
• [Journal Article] Protective Effect of D-Alanine Against Acute Kidney Injury. (2022)
  • Author(s): Iwata Y, Nakade Y, Kitajima S, Yoneda-Nakagawa S, Oshima M, Sakai N, Ogura H, Sato K, Toyama T, Yamamura Y, Miyagawa T,Yamazaki H, Hara A, Shimizu M, Furuichi K, Mita M, Hamase K, Tanaka T, Nishida M, Muramatsu W, Yamamoto H, Shichino S, Ueha S, Matsushima K, Wada T.
  • Journal Title: Am J Physiol Renal Physiol. Volume: 322 Pages: F667-F679
  • DOI: 10.1152/ajprenal.00198.2021
  • Peer Reviewed
• [Journal Article] Morphological and functional adaptation of pancreatic islet blood vessels to insulin resistance is impaired in diabetic db/db mice (2022)
  • Author(s): Okajima Yuka、Matsuzaka Takashi、Miyazaki Shun、Motomura Kaori、Ohno Hiroshi、Sharma Rahul、Shimura Takuya、Istiqamah Nurani、Han Song-iee、......i、Takeuchi Yoshinori、Sekiya Motohiro、Yahagi Naoya、Nakagawa Yoshimi、Tomita Tsutomu、Shimano Hitoshi
  • Journal Title: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease Volume: 1868 Pages: 166339～166339
  • DOI: 10.1016/j.bbadis.2022.166339
  • Peer Reviewed / Open Access
• [Journal Article] Human iPS cell-derived cartilaginous tissue spatially and functionally replaces nucleus pulposus (2022)
  • Author(s): Kamatani Takashi、Hagizawa Hiroki、Yarimitsu Seido、Morioka Miho、Koyamatsu Saeko、Sugimoto Michihiko、Kodama Joe、Yamane Junko、Ishiguro Hiroyuki、Shichino Shigeyuki、Abe Kuniya、Fujibuchi Wataru、Fujie Hiromichi、Kaito Takashi、Tsumaki Noriyuki
  • Journal Title: Biomaterials Volume: 284 Pages: 121491～121491
  • DOI: 10.1016/j.biomaterials.2022.121491
  • Peer Reviewed / Open Access
• [Journal Article] Moyamoya disease: diagnosis and interventions. (2022)
  • Author(s): Ihara M, Yamamoto Y, Hattori Y, Liu W, Kobayashi H, Ishiyama H, Yoshimoto T, Miyawaki S, Clausen T, Bang OY, Steinberg GK, Tournier-Lasserve E, Koizumi A.
  • Journal Title: Lancet Neurology. Volume: - Pages: -
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Suppression of RNF213, a susceptibility gene for moyamoya disease, inhibits endoplasmic reticulum stress through SEL1L upregulation (2022)
  • Author(s): Ahmed Sharif、Habu Toshiyuki、Kim Jiyeong、Okuda Hiroko、Oikawa Shinji、Murata Mariko、Koizumi Akio、Kobayashi Hatasu
  • Journal Title: Biochemical and Biophysical Research Communications Volume: 609 Pages: 62～68
  • DOI: 10.1016/j.bbrc.2022.04.007
  • Peer Reviewed / Open Access
• [Journal Article] Oridonin inhibits SASP by blocking p38 and NF-κB pathways in senescent cells (2022)
  • Author(s): Yasuda Shusuke、Horinaka Mano、Iizumi Yosuke、Goi Wakana、Sukeno Mamiko、Sakai Toshiyuki
  • Journal Title: Biochemical and Biophysical Research Communications Volume: 590 Pages: 55～62
  • DOI: 10.1016/j.bbrc.2021.12.098
  • Peer Reviewed / Open Access
• [Journal Article] Group IIA secreted phospholipase A2 controls skin carcinogenesis and psoriasis by shaping the gut microbiota (2022)
  • Author(s): Miki Yoshimi、Taketomi Yoshitaka、Kidoguchi Yuh、Yamamoto Kei、Muramatsu Kazuaki、Nishito Yasumasa、Park Jonguk、Hosomi Koji、Mizuguchi Kenji、Kunisawa Jun、Soga Tomoyoshi、Boilard Eric、B. Gowda Siddabasave Gowda、Ikeda Kazutaka、Arita Makoto、Murakami Makoto
  • Journal Title: JCI Insight Volume: 7 Pages: e152611-e152611
  • DOI: 10.1172/jci.insight.152611
  • Peer Reviewed / Open Access
• [Journal Article] Secreted phospholipase A2 modifies extracellular vesicles and accelerates B cell lymphoma (2022)
  • Author(s): Kudo Kai、Miki Yoshimi、Carreras Joaquim、Nakayama Shunya、Nakamoto Yasushi、Ito Masatoshi、Nagashima Etsuko、Yamamoto Kei、Higuchi Hiroshi、Morita Shin-ya、Inoue Asuka、Aoki Junken、Ando Kiyoshi、Nakamura Naoya、Murakami Makoto、Kotani Ai
  • Journal Title: Cell Metabolism Volume: 34 Pages: 615～633.e8
  • DOI: 10.1016/j.cmet.2022.02.011
  • Peer Reviewed
• [Journal Article] Group IVE cytosolic phospholipase A2 limits psoriatic inflammation by mobilizing the anti‐inflammatory lipid N‐acylethanolamine. (2022)
  • Author(s): Liang Luyiyun、Takamiya Rina、Miki Yoshimi、Heike Kanako、Taketomi Yoshitaka、Sugimoto Nao、Yamaguchi Midori、Shitara Hiroshi、Nishito Yasumasa、Kobayashi Tetsuyuki、Hirabayashi Tetsuya、Murakami Makoto
  • Journal Title: The FASEB Journal Volume: 36 Pages: -
  • DOI: 10.1096/fj.202101958R
  • Peer Reviewed / Open Access
• [Journal Article] Molecular mechanism of crosstalk between immune and metabolic systems in metabolic syndrome (2022)
  • Author(s): Hachiya Rumi、Tanaka Miyako、Itoh Michiko、Suganami Takayoshi
  • Journal Title: Inflammation and Regeneration Volume: 42 Pages: 13-13
  • DOI: 10.1186/s41232-022-00198-7
  • Peer Reviewed / Open Access
• [Journal Article] Glucocorticoid imprints a low glucose metabolism onto CD8 T cells and induces the persistent suppression of the immune response (2022)
  • Author(s): Konishi Amane、Suzuki Junpei、Kuwahara Makoto、Matsumoto Akira、Nomura Shunsuke、Soga Tomoyoshi、Yorozuya Toshihiro、Yamashita Masakatsu
  • Journal Title: Biochemical and Biophysical Research Communications Volume: 588 Pages: 34～40
  • DOI: 10.1016/j.bbrc.2021.12.050
  • Peer Reviewed / Open Access
• [Journal Article] VDR regulates simulated microgravity-induced atrophy in C2C12 myotubes (2022)
  • Author(s): Yuzawa Ryo、Koike Hiroyuki、Manabe Ichiro、Oishi Yumiko
  • Journal Title: Scientific Reports Volume: 12 Pages: 1377-1377
  • DOI: 10.1038/s41598-022-05354-0
  • Peer Reviewed / Open Access
• [Journal Article] Pirfenidone attenuates acetaminophen-induced liver injury via suppressing c-Jun N-terminal kinase phosphorylation (2022)
  • Author(s): Tashiro Shigeki、Tanaka Masatake、Goya Takeshi、Aoyagi Tomomi、Kurokawa Miho、Imoto Koji、Kuwano Akifumi、Takahashi Motoi、Suzuki Hideo、Kohjima Motoyuki、Kato Masaki、Ogawa Yoshihiro
  • Journal Title: Toxicology and Applied Pharmacology Volume: 434 Pages: 115817～115817
  • DOI: 10.1016/j.taap.2021.115817
  • Peer Reviewed
• [Journal Article] The Efficacy of Tofogliflozin on Metabolic Dysfunction-Associated Fatty Liver Disease (2022)
  • Author(s): Goya Takeshi、Imoto Koji、Tashiro Shigeki、Aoyagi Tomomi、Takahashi Motoi、Kurokawa Miho、Suzuki Hideo、Tanaka Masatake、Kato Masaki、Kohjima Motoyuki、Ogawa Yoshihiro
  • Journal Title: Gastroenterology Insights Volume: 13 Pages: 20～26
  • DOI: 10.3390/gastroent13010003
  • Peer Reviewed / Open Access
• [Journal Article] Corticosteroid suppresses urea-cycle-related gene expressions in ornithine transcarbamylase deficiency (2022)
  • Author(s): Imoto Koji、Tanaka Masatake、Goya Takeshi、Aoyagi Tomomi、Takahashi Motoi、Kurokawa Miho、Tashiro Shigeki、Kato Masaki、Kohjima Motoyuki、Ogawa Yoshihiro
  • Journal Title: BMC Gastroenterology Volume: 22 Pages: 144-144
  • DOI: 10.1186/s12876-022-02213-0
  • Peer Reviewed / Open Access
• [Journal Article] Essential Roles of the Transcription Factor NR4A1 in Regulatory T Cell Differentiation under the Influence of Immunosuppressants. (2022)
  • Author(s): Sekiya T, Kasahara H, Takemura R, Fujita S, Kato J, Doki N, Katayama Y, Ozawa Y, Takada S, Eto T, Fukuda T, Ichinohe T, Takanashi M, Onizuka M, Atsuta Y, Okamoto S, Yoshimura A, Takaki S, Mori T.
  • Journal Title: J Immunol. Volume: 208 Pages: 2122-2130
  • DOI: 10.4049/jimmunol.2100808
  • Peer Reviewed / Open Access
• [Journal Article] Comparison Between Nr4a Transcription Factor Regulation and Function in Lymphoid and Tumor Treg Cells (2022)
  • Author(s): Sekiya Takashi
  • Journal Title: Frontiers in Immunology Volume: 13 Pages: -
  • DOI: 10.3389/fimmu.2022.866339
  • Peer Reviewed / Open Access
• [Journal Article] The C-type lectin receptor Clec1A plays an important role in the development of experimental autoimmune encephalomyelitis by enhancing antigen presenting ability of dendritic cells and inducing inflammatory cytokine IL-17 (2022)
  • Author(s): MAKUSHEVA Yulia、CHUNG Soo-Hyun、AKITSU Aoi、MAEDA Natsumi、MARUHASHI Takumi、YE Xiao-Qi、KAIFU Tomonori、SAIJO Shinobu、SUN Haiyang、HAN Wei、TANG Ce、IWAKURA Yoichiro
  • Journal Title: Experimental Animals Volume: - Pages: -
  • DOI: 10.1538/expanim.21-0191
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] A Method for Detection of Markers for Epithelial-Mesenchymal Transition based on Single Cell Transcriptomic Data (2022)
  • Author(s): Murayama Kosho、Matsuda Hideo
  • Journal Title: Proceedings of 12th International Conference on Bioscience, Biochemistry and Bioinformatics Volume: - Pages: 57-62
  • DOI: 10.1145/3510427.3510436
  • Peer Reviewed / Open Access
• [Journal Article] Detection of Biomarkers for Epithelial-Mesenchymal Transition with Single-Cell Trajectory Inference (2022)
  • Author(s): Murayama Kosho、Matsuda Hideo
  • Journal Title: Frontiers in Bioscience-Landmark Volume: 27 Pages: 127～127
  • DOI: 10.31083/j.fbl2704127
  • Peer Reviewed / Open Access
• [Journal Article] Protective effect of <scp>d</scp>-alanine against acute kidney injury (2022)
  • Author(s): Iwata Yasunori、Nakade Yusuke、Kitajima Shinji、Yoneda-Nakagawa Shiori、Oshima Megumi、Sakai Norihiko、Ogura Hisayuki、Sato Koichi、Toyama Tadashi、Yamamura Yuta、.......、Tanaka Tomohiro、Nishida Motohiro、Muramatsu Wataru、Yamamoto Hisashi、Shichino Shigeyuki、Ueha Satoshi、Matsushima Kouji、Wada Takashi
  • Journal Title: American Journal of Physiology-Renal Physiology Volume: 322 Pages: F667～F679
  • DOI: 10.1152/ajprenal.00198.2021
  • Peer Reviewed
• [Journal Article] TAS-Seq is a robust and sensitive amplification method for bead-based scRNA-seq. (2022)
  • Author(s): Shichino S, Ueha S, Hashimoto S, Ogawa T, Aoki H, Wu B, Chen CY, Kitabatake M, Ouji-Sageshima N, Sawabata N, Kawaguchi T, Okayama T, Sugihara E, Hontsu S, Ito T, Iwata Y, Wada T, Ikeo K, Sato T, Matsushima K.
  • Journal Title: Communications Biology Volume: - Pages: -
  • Peer Reviewed / Open Access
• [Journal Article] Proportional Tumor Infiltration of T Cells <i>via</i> Circulation Duplicates the T Cell Receptor Repertoire in a Bilateral Tumor Mouse Model. (2021)
  • Author(s): Tsunoda M, Aoki H, Shimizu H, Shichino S, Matsushima K, Ueha S.
  • Journal Title: Front Immunol. Volume: 12 Pages: 744381-744381
  • DOI: 10.3389/fimmu.2021.744381
  • Peer Reviewed / Open Access
• [Journal Article] Macrophages in lung fibrosis. (2021)
  • Author(s): Ogawa T, Shichino S, Ueha S, Matsushima K.
  • Journal Title: Int Immunol. Volume: 33 Pages: 665-671
  • DOI: 10.1093/intimm/dxab040
  • Peer Reviewed
• [Journal Article] Greater extent of blood-tumor TCR repertoire overlap is associated with favorable clinical responses to PD-1 blockade. (2021)
  • Author(s): Aoki H, Ueha S, Nakamura Y, Shichino S, Nakajima H, Shimomura M, Sato A, Nakatsura T, Yoshino T, Matsushima K.
  • Journal Title: Cancer Sci. Volume: 112 Pages: 2993-3004
  • DOI: 10.1111/cas.14975
  • Peer Reviewed / Open Access
• [Journal Article] Combining an alarmin HMGN1 peptide with PD-L1 blockade results in robust antitumor effects with a concomitant increase of stem-like/progenitor exhausted CD8+ T cells. (2021)
  • Author(s): Chen CY, Ueha S, Ishiwata Y, Shichino S, Yokochi S, Yang D, Oppenheim JJ, Ogiwara H, Deshimaru S, Kanno Y, Aoki H, Ogawa T, Shibayama S, Matsushima K.
  • Journal Title: Cancer Immunol Res. Volume: 9 Pages: 1214-1228
  • DOI: 10.1158/2326-6066.CIR-21-0265
  • Peer Reviewed
• [Journal Article] Transient depletion of CD4+ cells induces drastic remodeling of the repertoire of T-cell receptors in gastrointestinal cancer. (2021)
  • Author(s): Aoki H, Ueha S, Shichino S, Ogiwara H, Shitara K, Shimomura M, Suzuki T, Nakatsura T, Yamashita M, Kitano S, Kuroda S, Wakabayashi M, Kurachi M, Ito S, Doi T, Matsushima K.
  • Journal Title: Cancer Immunol Res. Volume: 9 Pages: 624-636
  • DOI: 10.1158/2326-6066.CIR-20-0989
  • Peer Reviewed
• [Journal Article] D-Serine inhibits the attachment and biofilm formation of methicillin-resistant Staphylococcus aureus. (2021)
  • Author(s): Iwata Y, Sakai N, Yoneda I, Senda Y, Sakai-Takemori Y, Oshima M, Nakagawa-Yoneda S, Ogura H, Sato K, Minami T, Kitajima S, Toyama T, Yamamura Y, Miyagawa T, Hara A, Shimizu M, Furuichi K, Matsushima K, Wada T.
  • Journal Title: Biochem Biophys Res Commun. Volume: 537 Pages: 50-56
  • DOI: 10.1016/j.bbrc.2020.12.078
  • Peer Reviewed / Open Access
• [Journal Article] Starvation‐induced transcription factor CREBH negatively governs body growth by controlling GH signaling (2021)
  • Author(s): Nakagawa Yoshimi、Kumagai Kae、Han Song‐iee、Mizunoe Yuhei、Araki Masaya、Mizuno Seiya、Ohno Hiroshi、Matsuo Kazuya、Yamada Yasunari、Kim Jun‐dal、Miyamoto Takafumi、Sekiya Motohiro、Konishi Morichika、Itoh Nobuyuki、Matsuzaka Takashi、Takahashi Satoru、Sone Hirohito、Shimano Hitoshi
  • Journal Title: The FASEB Journal Volume: 35 Pages: e21663-e21663
  • DOI: 10.1096/fj.202002784RR
  • Peer Reviewed / Open Access
• [Journal Article] Genetic ablation of Nrf2 exacerbates neurotoxic effects of acrylamide in mice (2021)
  • Author(s): Ekuban Frederick Adams、Zong Cai、Takikawa Madoka、Morikawa Kota、Sakurai Toshihiro、Ichihara Sahoko、Itoh Ken、Yamamoto Masayuki、Ohsako Seiichiroh、Ichihara Gaku
  • Journal Title: Toxicology Volume: 456 Pages: 152785～152785
  • DOI: 10.1016/j.tox.2021.152785
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Nrf2 Activation Attenuates Acrylamide-Induced Neuropathy in Mice (2021)
  • Author(s): Davuljigari Chand Basha、Ekuban Frederick Adams、Zong Cai、Fergany Alzahraa A. M.、Morikawa Kota、Ichihara Gaku
  • Journal Title: International Journal of Molecular Sciences Volume: 22 Pages: 5995～5995
  • DOI: 10.3390/ijms22115995
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Role of Macrophages in Cytotoxicity, Reactive Oxygen Species Production and DNA Damage in 1,2-Dichloropropane-Exposed Human Cholangiocytes In Vitro (2021)
  • Author(s): Ekuban Abigail、Zong Cai、Ekuban Frederick Adams、Kimura Yusuke、Takizawa Ryoya、Morikawa Kota、Kinoshita Kazuo、Ichihara Sahoko、Ohsako Seiichiroh、Ichihara Gaku
  • Journal Title: Toxics Volume: 9 Pages: 128～128
  • DOI: 10.3390/toxics9060128
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] 1,2-Dichloropropane induces γ-H2AX expression in human cholangiocytes only in the presence of macrophages (2021)
  • Author(s): Takizawa Ryoya、Ichihara Sahoko、Zong Cai、Kinoshita Kazuo、Sakurai Toshihiro、Ikegami Akihiko、Mise Nathan、Ichihara Gaku
  • Journal Title: Toxicology Letters Volume: 349 Pages: 134～144
  • DOI: 10.1016/j.toxlet.2021.06.009
  • Peer Reviewed
• [Journal Article] AMPK activation reverts mouse epiblast stem cells to naive state (2021)
  • Author(s): Liu Yajing、Yamane Junko、Tanaka Akito、Fujibuchi Wataru、Yamashita Jun K.
  • Journal Title: iScience Volume: 24 Pages: 102783～102783
  • DOI: 10.1016/j.isci.2021.102783
  • Peer Reviewed / Open Access
• [Journal Article] Time-Series Analysis of Gene Correlation Networks based on Single-Cell Transcriptome Data (2021)
  • Author(s): Asano Yasuhito、Ogawa Tatsuro、Shichino Shigeyuki、Ueha Satoshi、Matsushima Koji、Ogura Atsushi
  • Journal Title: 2021 IEEE International Conference on Bioinformatics and Biomedicine (BIBM) Volume: - Pages: 2134-2141
  • DOI: 10.1109/BIBM52615.2021.9669412
  • Peer Reviewed / Open Access
• [Journal Article] Mast Cell-Specific Deletion of Group III Secreted Phospholipase A2 Impairs Mast Cell Maturation and Functions (2021)
  • Author(s): Taketomi Yoshitaka、Endo Yuki、Higashi Takayoshi、Murase Remi、Ono Tomio、Taya Choji、Kobayashi Tetsuyuki、Murakami Makoto
  • Journal Title: Cells Volume: 10 Pages: 1691～1691
  • DOI: 10.3390/cells10071691
  • Peer Reviewed / Open Access
• [Journal Article] The sodium-glucose cotransporter-2 inhibitor Tofogliflozin prevents the progression of nonalcoholic steatohepatitis?associated liver tumors in a novel murine model (2021)
  • Author(s): Yoshioka Naoki、Tanaka Miyako、Ochi Kozue、Watanabe Akiko、Ono Kenji、Sawada Makoto、Ogi Tomoo、Itoh Michiko、Ito Ayaka、Shiraki Yukihiro、Enomoto Atsushi、Ishigami Masatoshi、Fujishiro Mitsuhiro、Ogawa Yoshihiro、Suganami Takayoshi
  • Journal Title: Biomedicine &amp; Pharmacotherapy Volume: 140 Pages: 111738～111738
  • DOI: 10.1016/j.biopha.2021.111738
  • Peer Reviewed / Open Access
• [Journal Article] Dietary Supplementation With Eicosapentaenoic Acid Inhibits Plasma Cell Differentiation and Attenuates Lupus Autoimmunity (2021)
  • Author(s): Kobayashi Azusa、Ito Ayaka、Shirakawa Ibuki、Tamura Atsushi、Tomono Susumu、Shindou Hideo、Hedde Per Niklas、Tanaka Miyako、Tsuboi Naotake、Ishimoto Takuji、Akashi-Takamura Sachiko、Maruyama Shoichi、Suganami Takayoshi
  • Journal Title: Frontiers in Immunology Volume: 12 Pages: 650856-650856
  • DOI: 10.3389/fimmu.2021.650856
  • Peer Reviewed / Open Access
• [Journal Article] Macrophages rely on extracellular serine to suppress aberrant cytokine production (2021)
  • Author(s): Kurita Kento、Ohta Hiroya、Shirakawa Ibuki、Tanaka Miyako、Kitaura Yasuyuki、Iwasaki Yorihiro、Matsuzaka Takashi、Shimano Hitoshi、Aoe Seiichiro、Arima Hiroshi、Ogawa Yoshihiro、Ito Ayaka、Suganami Takayoshi
  • Journal Title: Scientific Reports Volume: 11 Pages: 11137-11137
  • DOI: 10.1038/s41598-021-90086-w
  • Peer Reviewed / Open Access
• [Journal Article] The Loss of H3K27 Histone Demethylase Utx in T Cells Aggravates Allergic Contact Dermatitis (2021)
  • Author(s): Inoue Takashi、Omori-Miyake Miyuki、Maruyama Saho、Okabe Masataka、Kuwahara Makoto、Honda Hiroaki、Miura Hiromasa、Yamashita Masakatsu
  • Journal Title: The Journal of Immunology Volume: 207 Pages: 2223～2234
  • DOI: 10.4049/jimmunol.2001160
  • Peer Reviewed / Open Access
• [Journal Article] Identification of a KLF5-dependent program and drug development for skeletal muscle atrophy (2021)
  • Author(s): Liu Lin、Koike Hiroyuki、Ono Takehito、Hayashi Shinichiro、Kudo Fujimi、Kaneda Atsushi、Kagechika Hiroyuki、Manabe Ichiro、Nakashima Tomoki、Oishi Yumiko
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• [Journal Article] Microcirculatory disturbance in acute liver injury (2021)
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  • Peer Reviewed / Open Access
• [Journal Article] IL-1β plays an important role in pressure overoad-induced atrial fibrillation in mice. (2019)
  • Author(s): Matsushita, N., Ishida, N., Ibi, M., Saito, M., Takahashi, M., Taniguchi, S., Iwakura, Y., Morino, Y., Taira, E., Sawa, Y., and Hirose, M.
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  • Author(s): Miyabe, C., Miyabe, Y., Moreno, L., Lian, J., Rahimi, R. A., Miura, N. N., Ohno, N., Iwakura, Y., Kawakami, T., and Luster, A. D.
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• [Journal Article] Heterozygous Tbk1 loss has opposing effects in early and late stages of ALS in mice. (2019)
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• [Journal Article] USP15 participates in HCV propagation through the regulation of viral RNA translation and lipid droplet formation. (2019)
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• [Journal Article] Engraftment and proliferation potential of embryonic lung tissue cells in irradiated mice with emphysema. (2019)
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• [Journal Article] Combined treatment with HMGN1 and anti-CD4 depleting antibody reverses T cell exhaustion and exerts robust anti-tumor effects in mice. (2019)
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• [Journal Article] Mutant KCNJ3 and KCNJ5 Potassium Channels as Novel Molecular Targets in Bradyarrhythmias and Atrial Fibrillation. (2019)
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  • Peer Reviewed / Open Access
• [Journal Article] Characteristics of Japanese Patients with Nonvalvular Atrial Fibrillation on Anticoagulant Treatment: A Descriptive Analysis of J-dabigatran Surveillance and JAPAF Study. (2019)
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  • Journal Title: Cardiol Ther. Volume: 8 Pages: 43-54
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• [Journal Article] Moyamoya Disease Susceptibility Variant RNF213 p.R4810K Increases the Risk of Ischemic Stroke Attributable to Large-Artery Atherosclerosis. (2019)
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  • Journal Title: Circulation. Volume: 139 Pages: 295-298
  • DOI: 10.1161/CIRCULATIONAHA.118.038439
  • Peer Reviewed / Open Access
• [Journal Article] Glucocorticoid receptor suppresses gene expression of Rev-erbα (Nr1d1) through interaction with the CLOCK complex. (2019)
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• [Journal Article] Role of eosinophils in a murine model of inflammatory bowel disease. (2019)
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  • Peer Reviewed / Open Access
• [Journal Article] Transcriptome network analysis identifies protective role of the LXR-SREBP-1c axis in murine pulmonary fibrosis. (2019)
  • Author(s): Shichino S, Ueha S, Hashimoto S, Otsuji M, Abe J, Tsukui T, Deshimaru S, Nakajima T, Kosugi-Kanaya M, Shand FH, Inagaki Y, Shimano H, Matsushima K.
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  • Peer Reviewed / Open Access
• [Journal Article] Inhibition of HBV Transcription From cccDNA With Nitazoxanide by Targeting the HBx?DDB1 Interaction (2019)
  • Author(s): Sekiba Kazuma、Otsuka Motoyuki、Ohno Motoko、Yamagami Mari、Kishikawa Takahiro、Suzuki Tatsunori、Ishibashi Rei、Seimiya Takahiro、Tanaka Eri、Koike Kazuhiko
  • Journal Title: Cellular and Molecular Gastroenterology and Hepatology Volume: 7 Pages: 297～312
  • DOI: 10.1016/j.jcmgh.2018.10.010
  • Peer Reviewed
• [Journal Article] TAK1 Prevents Endothelial Apoptosis and Maintains Vascular Integrity (2019)
  • Author(s): Naito Hisamichi、Iba Tomohiro、Wakabayashi Taku、Tai-Nagara Ikue、Suehiro Jun-ichi、Jia Weizhen、Eino Daisuke、Sakimoto Susumu、Muramatsu Fumitaka、Kidoya Hiroyasu、Sakurai Hiroyuki、Satoh Takashi、Akira Shizuo、Kubota Yoshiaki、Takakura Nobuyuki
  • Journal Title: Developmental Cell Volume: 48 Pages: 151～166.e7
  • DOI: 10.1016/j.devcel.2018.12.002
  • Peer Reviewed
• [Journal Article] Role of interleukin-17 in a murine community-associated methicillin-resistant Staphylococcus aureus pneumonia model (2019)
  • Author(s): Shibue Yasushi、Kimura Soichiro、Kajiwara Chiaki、Iwakura Yoichiro、Yamaguchi Keizo、Tateda Kazuhiro
  • Journal Title: Microbes and Infection Volume: 21 Pages: 33～39
  • DOI: 10.1016/j.micinf.2018.06.006
  • Peer Reviewed
• [Journal Article] Dectin-2?Mediated Signaling Leads to Delayed Skin Wound Healing through Enhanced Neutrophilic Inflammatory Response and Neutrophil Extracellular Trap Formation (2019)
  • Author(s): Miura Takayuki、Kawakami Kazuyoshi、Kanno Emi、Tanno Hiromasa、Tada Hiroyuki、Sato Noriko、Masaki Airi、Yokoyama Rin、Kawamura Kotone、Kitai Yuki、Takagi Naoyuki、Yamaguchi Kenji、Yamaguchi Natsuki、Kyo Yoshika、Ishii Keiko、Imai Yoshimichi、Saijo Shinobu、Iwakura Yoichiro、Tachi Masahiro
  • Journal Title: Journal of Investigative Dermatology Volume: 139 Pages: 702～711
  • DOI: 10.1016/j.jid.2018.10.015
  • Peer Reviewed
• [Journal Article] Dectin-1 Contributes to Myocardial Ischemia/Reperfusion Injury by Regulating Macrophage Polarization and Neutrophil Infiltration (2019)
  • Author(s): Fan Qin、Tao Rong、Zhang Hang、Xie Hongyang、Lu Lin、Wang Ting、Su Min、Hu Jian、Zhang Qi、Chen Qiujing、Iwakura Yoichiro、Shen Weifeng、Zhang Ruiyan、Yan Xiaoxiang
  • Journal Title: Circulation Volume: 139 Pages: 663～678
  • DOI: 10.1161/CIRCULATIONAHA.118.036044
  • Peer Reviewed
• [Journal Article] Circulating Concentrations of Insulin Resistance-Associated Hepatokines, Selenoprotein P and Leukocyte Cell-Derived Chemotaxin 2, during an Oral Glucose Tolerance Test in Humans (2019)
  • Author(s): Mohri Kensuke、Misu Hirofumi、Takayama Hiroaki、Ishii Kiyo-aki、Kikuchi Akihiro、Lan Fei、Enyama Yasufumi、Takeshita Yumie、Saito Yoshiro、Kaneko Shuichi、Takamura Toshinari
  • Journal Title: Biological and Pharmaceutical Bulletin Volume: 42 Pages: 373～378
  • DOI: 10.1248/bpb.b18-00549
  • Peer Reviewed
• [Journal Article] Higher pulse pressure predicts initiation of dialysis in Japanese patients with diabetes (2019)
  • Author(s): Osawa Taeko、Fujihara Kazuya、Harada Mayuko、Yamamoto Masahiko、Ishizawa Masahiro、Suzuki Hiroshi、Ishiguro Hajime、Matsubayashi Yasuhiro、Seida Hiroyasu、Yamanaka Nauta、Tanaka Shiro、Shimano Hitoshi、Kodama Satoru、Sone Hirohito
  • Journal Title: Diabetes/Metabolism Research and Reviews Volume: 35 Pages: e3120～e3120
  • DOI: 10.1002/dmrr.3120
  • Peer Reviewed
• [Journal Article] Mesenchymal-Epithelial Interactome Analysis Reveals Essential Factors Required for Fibroblast-Free Alveolosphere Formation (2019)
  • Author(s): Shiraishi Kazushige、Shichino Shigeyuki、Ueha Satoshi、Nakajima Takuya、Hashimoto Shinichi、Yamazaki Satoshi、Matsushima Kouji
  • Journal Title: iScience Volume: 11 Pages: 318～333
  • DOI: 10.1016/j.isci.2018.12.022
  • Peer Reviewed
• [Journal Article] ISGF3 with reduced phosphorylation is associated with constitutive expression of interferon-induced genes in aging cells (2018)
  • Author(s): Yamagami Mari、Otsuka Motoyuki、Kishikawa Takahiro、Sekiba Kazuma、Seimiya Takahiro、Tanaka Eri、Suzuki Tatsunori、Ishibashi Rei、Ohno Motoko、Koike Kazuhiko
  • Journal Title: npj Aging and Mechanisms of Disease Volume: 4 Pages: 11
  • DOI: 10.1038/s41514-018-0030-6
  • Peer Reviewed
• [Journal Article] Inflammation and de-differentiation in pancreatic carcinogenesis (2018)
  • Author(s): Seimiya Takahiro、Otsuka Motoyuki、Iwata Takuma、Tanaka Eri、Suzuki Tatsunori、Sekiba Kazuma、Yamagami Mari、Ishibashi Rei、Koike Kazuhiko
  • Journal Title: World Journal of Clinical Cases Volume: 6 Pages: 882～891
  • DOI: 10.12998/wjcc.v6.i15.882
  • Peer Reviewed
• [Journal Article] Angiopoietin-2 exacerbates cardiac hypoxia and inflammation after myocardial infarction (2018)
  • Author(s): Lee Seung-Jun、Lee Choong-kun、Kang Seok、Park Intae、Kim Yoo Hyung、Kim Seo Ki、Hong Seon Pyo、Bae Hosung、He Yulong、Kubota Yoshiaki、Koh Gou Young
  • Journal Title: Journal of Clinical Investigation Volume: 128 Pages: 5018～5033
  • DOI: 10.1172/JCI99659
  • Peer Reviewed
• [Journal Article] Hematopoietic insults damage bone marrow niche by activating p53 in vascular endothelial cells (2018)
  • Author(s): Si Sha、Nakajima-Takagi Yaeko、Iga Takahito、Tsuji Mayoko、Hou Libo、Oshima Motohiko、Koide Shuhei、Saraya Atsunori、Yamazaki Satoshi、Takubo Keiyo、Kubota Yoshiaki、Minamino Tohru、Iwama Atsushi
  • Journal Title: Experimental Hematology Volume: 63 Pages: 41～51.e1
  • DOI: 10.1016/j.exphem.2018.04.006
  • Peer Reviewed
• [Journal Article] Degradation of the endoplasmic reticulum?anchored transcription factor MyRF by the ubiquitin ligase SCFFbxw7in a manner dependent on the kinase GSK-3 (2018)
  • Author(s): Nakayama Shogo、Yumimoto Kanae、Kawamura Atsuki、Nakayama Keiichi I.
  • Journal Title: Journal of Biological Chemistry Volume: 293 Pages: 5705～5714
  • DOI: 10.1074/jbc.RA117.000741
  • Peer Reviewed
• [Journal Article] Efficient Generation of Small Intestinal Epithelial-like Cells from Human iPSCs for Drug Absorption and Metabolism Studies (2018)
  • Author(s): Negoro Ryosuke、Takayama Kazuo、Kawai Kanae、Harada Kazuo、Sakurai Fuminori、Hirata Kazumasa、Mizuguchi Hiroyuki
  • Journal Title: Stem Cell Reports Volume: 11 Pages: 1539～1550
  • DOI: 10.1016/j.stemcr.2018.10.019
  • Peer Reviewed
• [Journal Article] Fbxo22-mediated KDM4B degradation determines selective estrogen receptor modulator activity in breast cancer (2018)
  • Author(s): Johmura Yoshikazu、Maeda Ichiro、Suzuki Narumi、Wu Wenwen、Goda Atsushi、Morita Mariko、Yamaguchi Kiyoshi、Yamamoto Mizuki、Nagasawa Satoi、Kojima Yasuyuki、Tsugawa Koichiro、Inoue Natsuko、Miyoshi Yasuo、Osako Tomo、Akiyama Futoshi、Maruyama Reo、Inoue Jun-ichiro、Furukawa Yoichi、Ohta Tomohiko、Nakanishi Makoto
  • Journal Title: Journal of Clinical Investigation Volume: 128 Pages: 5603～5619
  • DOI: 10.1172/JCI121679
  • Peer Reviewed
• [Journal Article] Isozyme-Specific Role of SAD-A in Neuronal Migration During Development of Cerebral Cortex (2018)
  • Author(s): Nakanishi Keiko、Niida Hiroyuki、Tabata Hidenori、Ito Tsuyoshi、Hori Yuki、Hattori Madoka、Johmura Yoshikazu、Yamada Chisato、Ueda Takashi、Takeuchi Kosei、Yamada Kenichiro、Nagata Koh-ichi、Wakamatsu Nobuaki、Kishi Masashi、Pan Y Albert、Ugawa Shinya、Shimada Shoichi、Sanes Joshua R、Higashi Yujiro、Nakanishi Makoto
  • Journal Title: Cerebral Cortex Volume: - Pages: -
  • DOI: 10.1093/cercor/bhy253
  • Peer Reviewed
• [Journal Article] Production of low-molecular weight soluble yeast β-glucan by an acid degradation method (2018)
  • Author(s): Ishimoto Yuina、Ishibashi Ken-ichi、Yamanaka Daisuke、Adachi Yoshiyuki、Kanzaki Ken、Iwakura Yoichiro、Ohno Naohito
  • Journal Title: International Journal of Biological Macromolecules Volume: 107 Pages: 2269～2278
  • DOI: 10.1016/j.ijbiomac.2017.10.094
  • Peer Reviewed
• [Journal Article] IL-1R2 deficiency suppresses dextran sodium sulfate-induced colitis in mice via regulation of microbiota (2018)
  • Author(s): Yoshida Kaori、Murayama Masanori A.、Shimizu Kenji、Tang Ce、Katagiri Nanako、Matsuo Kenzo、Fukai Fumio、Iwakura Yoichiro
  • Journal Title: Biochemical and Biophysical Research Communications Volume: 496 Pages: 934～940
  • DOI: 10.1016/j.bbrc.2018.01.116
  • Peer Reviewed
• [Journal Article] HER2 Overexpression Triggers an IL1α Proinflammatory Circuit to Drive Tumorigenesis and Promote Chemotherapy Resistance (2018)
  • Author(s): Liu Shou、Lee Ji Shin、Jie Chunfa、Park Min Ho、Iwakura Yoichiro、Patel Yogin、Soni Mithil、Reisman David、Chen Hexin
  • Journal Title: Cancer Research Volume: 78 Pages: 2040～2051
  • DOI: 10.1158/0008-5472.CAN-17-2761
  • Peer Reviewed
• [Journal Article] Establishment and analysis of a novel mouse line carrying a conditional knockin allele of a cancer-specific FBXW7 mutation (2018)
  • Author(s): Ikenoue Tsuneo、Terakado Yumi、Zhu Chi、Liu Xun、Ohsugi Tomoyuki、Matsubara Daisuke、Fujii Tomoki、Kakuta Shigeru、Kubo Sachiko、Shibata Takuma、Yamaguchi Kiyoshi、Iwakura Yoichiro、Furukawa Yoichi
  • Journal Title: Scientific Reports Volume: 8 Pages: 2021
  • DOI: 10.1038/s41598-018-19769-1
  • Peer Reviewed
• [Journal Article] Myeloid-derived interleukin-1β drives oncogenic KRAS-NF-κΒ addiction in malignant pleural effusion (2018)
  • Author(s): Marazioti A, Lilis I, Vreka M, Apostolopoulou H, Kalogeropoulou A, Giopanou I, Giotopoulou GA, Krontira AC, Iliopoulou M, Kanellakis NI, Agalioti T, Giannou AD, Jones-Paris C, Iwakura Y, Kardamakis D, Blackwell TS, Taraviras S, Spella M, Stathopoulos GT.
  • Journal Title: Nature Communications Volume: 9 Pages: 672
  • DOI: 10.1038/s41467-018-03051-z
  • Peer Reviewed
• [Journal Article] Host defense against oral microbiota by bone-damaging T cells (2018)
  • Author(s): Tsukasaki Masayuki、Komatsu Noriko、Nagashima Kazuki、Nitta Takeshi、Pluemsakunthai Warunee、Shukunami Chisa、Iwakura Yoichiro、Nakashima Tomoki、Okamoto Kazuo、Takayanagi Hiroshi
  • Journal Title: Nature Communications Volume: 9 Pages: 701
  • DOI: 10.1038/s41467-018-03147-6
  • Peer Reviewed
• [Journal Article] Increased mTOR cancels out the effect of reduced Xbp-1 on antibody secretion in IL-1α-deficient B cells (2018)
  • Author(s): Zhu Gaizhi、Liu Xiaoling、Fang Ying、Zhai Bing、Xu Ruonan、Han Gencheng、Chen Guojiang、Xiao He、Hou Chunmei、Shen Beifen、Li Yan、Iwakura Yoichiro、Wang Liang、Jiang Zhenyu、Ma Ning、Liu Guangchao、Wang Renxi
  • Journal Title: Cellular Immunology Volume: 328 Pages: 9～17
  • DOI: 10.1016/j.cellimm.2018.02.015
  • Peer Reviewed
• [Journal Article] IL-25 enhances TH17 cell?mediated contact dermatitis by promoting IL-1β production by dermal dendritic cells (2018)
  • Author(s): Suto Hajime、Nambu Aya、Morita Hideaki、Yamaguchi Sachiko、Numata Takafumi、Yoshizaki Takamichi、Shimura Eri、Arae Ken、Asada Yousuke、Motomura Kenichiro、Kaneko Mari、Abe Takaya、Matsuda Akira、Iwakura Yoichiro、Okumura Ko、Saito Hirohisa、Matsumoto Kenji、Sudo Katsuko、Nakae Susumu
  • Journal Title: Journal of Allergy and Clinical Immunology Volume: 142 Pages: 1500～1509.e10
  • DOI: 10.1016/j.jaci.2017.12.1007
  • Peer Reviewed
• [Journal Article] Apaf1 plays a negative regulatory role in T cell responses by suppressing activation of antigen-stimulated T cells (2018)
  • Author(s): Tong Honglian、Miyake Yasunobu、Mi-ichi Fumika、Iwakura Yoichiro、Hara Hiromitsu、Yoshida Hiroki
  • Journal Title: PLOS ONE Volume: 13 Pages: e0195119
  • DOI: 10.1371/journal.pone.0195119
  • Peer Reviewed
• [Journal Article] A model of TH17-associated ileal hyperplasia that requires both IL-17A and IFNγ to generate self-tolerance and prevent colitis (2018)
  • Author(s): Jeschke Jonathan C.、Mayne Christopher G.、Ziegelbauer Jennifer、DeCiantis Christopher L.、Singh Selina、Kumar Suresh N.、Suchi Mariko、Iwakura Yoichiro、Drobyski William R.、Salzman Nita H、Williams Calvin B.
  • Journal Title: Mucosal Immunology Volume: 11 Pages: 1127～1137
  • DOI: 10.1038/s41385-018-0023-6
  • Peer Reviewed
• [Journal Article] IL-36α from Skin-Resident Cells Plays an Important Role in the Pathogenesis of Imiquimod-Induced Psoriasiform Dermatitis by Forming a Local Autoamplification Loop (2018)
  • Author(s): Hashiguchi Yuriko、Yabe Rikio、Chung Soo-Hyun、Murayama Masanori A.、Yoshida Kaori、Matsuo Kenzo、Kubo Sachiko、Saijo Shinobu、Nakamura Yuumi、Matsue Hiroyuki、Iwakura Yoichiro
  • Journal Title: The Journal of Immunology Volume: 201 Pages: 167～182
  • DOI: 10.4049/jimmunol.1701157
  • Peer Reviewed
• [Journal Article] Inhibition of interleukin-1 suppresses angiotensin II-induced aortic inflammation and aneurysm formation (2018)
  • Author(s): Isoda Kikuo、Akita Koji、Kitamura Kenichi、Sato-Okabayashi Yayoi、Kadoguchi Tomoyasu、Isobe Sarasa、Ohtomo Fumie、Sano Motoaki、Shimada Kazunori、Iwakura Yoichiro、Daida Hiroyuki
  • Journal Title: International Journal of Cardiology Volume: 270 Pages: 221～227
  • DOI: 10.1016/j.ijcard.2018.05.072
  • Peer Reviewed
• [Journal Article] BAFF inhibition attenuates fibrosis in scleroderma by modulating the regulatory and effector B cell balance (2018)
  • Author(s): Matsushita Takashi、Kobayashi Tadahiro、Mizumaki Kie、Kano Miyu、Sawada Tomoyo、Tennichi Momoko、Okamura Ai、Hamaguchi Yasuhito、Iwakura Yoichiro、Hasegawa Minoru、Fujimoto Manabu、Takehara Kazuhiko
  • Journal Title: Science Advances Volume: 4 Pages: eaas9944
  • DOI: 10.1126/sciadv.aas9944
  • Peer Reviewed
• [Journal Article] MAIT cells protect against pulmonary Legionella longbeachae infection (2018)
  • Author(s): Wang H, D'Souza C, Lim XY, Kostenko L, Pediongco TJ, Eckle SBG, Meehan BS, Shi M, Wang N, Li S, Liu L, Mak JYW, Fairlie DP, Iwakura Y, Gunnersen JM, Stent AW, Godfrey DI, Rossjohn J, Westall GP, Kjer-Nielsen L, Strugnell RA, McCluskey J, Corbett AJ, Hinks TSC, Chen Z.
  • Journal Title: Nature Communications Volume: 9 Pages: 3350
  • DOI: 10.1038/s41467-018-05202-8
  • Peer Reviewed
• [Journal Article] The ATP Transporter VNUT Mediates Induction of Dectin-1-Triggered Candida Nociception (2018)
  • Author(s): Maruyama K, Takayama Y, Sugisawa E, Yamanoi Y, Yokawa T, Kondo T, Ishibashi KI, Sahoo BR, Takemura N, Mori Y, Kanemaru H, Kumagai Y, Martino MM, Yoshioka Y, Nishijo H, Tanaka H, Sasaki A, Ohno N, Iwakura Y, Moriyama Y, Nomura M, Akira S, Tominaga M.
  • Journal Title: iScience Volume: 6 Pages: 306～318
  • DOI: 10.1016/j.isci.2018.08.007
  • Peer Reviewed
• [Journal Article] IL-36α is involved in hapten-specific T-cell induction, but not local inflammation, during contact hypersensitivity (2018)
  • Author(s): Numata Takafumi、Yoshizaki Takamichi、Yamaguchi Sachiko、Shimura Eri、Iwakura Yoichiro、Harada Kazutoshi、Sudo Katsuko、Tsuboi Ryoji、Nakae Susumu
  • Journal Title: Biochemical and Biophysical Research Communications Volume: 506 Pages: 429～436
  • DOI: 10.1016/j.bbrc.2018.10.104
  • Peer Reviewed
• [Journal Article] IL-6, IL-17 and Stat3 are required for auto-inflammatory syndrome development in mouse (2018)
  • Author(s): Oike Takatsugu、Kanagawa Hiroya、Sato Yuiko、Kobayashi Tami、Nakatsukasa Hiroko、Miyamoto Kana、Nakamura Satoshi、Kaneko Yosuke、Kobayashi Shu、Harato Kengo、Yoshimura Akihiko、Iwakura Yoichiro、Takeuchi Tsutomu、Matsumoto Morio、Nakamura Masaya、Niki Yasuo、Miyamoto Takeshi
  • Journal Title: Scientific Reports Volume: 8 Pages: 15783
  • DOI: 10.1038/s41598-018-34173-5
  • Peer Reviewed
• [Journal Article] TLR-stimulated IRAKM activates caspase-8 inflammasome in microglia and promotes neuroinflammation (2018)
  • Author(s): Zhang Cun-Jin、Jiang Meiling、Zhou Hao、Liu Weiwei、Wang Chenhui、Kang Zizhen、Han Bing、Zhang Quanri、Chen Xing、Xiao Jianxin、Fisher Amanda、Kaiser William J.、Murayama Masanori A.、Iwakura Yoichiro、Gao Ji、Carman Julie、Dongre Ashok、Dubyak George、Abbott Derek W.、Shi Fu-Dong、Ransohoff Richard M.、Li Xiaoxia
  • Journal Title: Journal of Clinical Investigation Volume: 128 Pages: 5399～5412
  • DOI: 10.1172/JCI121901
  • Peer Reviewed
• [Journal Article] Allergy inhibitory receptor‐1 inhibits autoantibody production via upregulation of apoptotic debris clearance by macrophages (2018)
  • Author(s): Iizuka Akira、Segawa Seiji、Kondo Yuya、Kaneko Shunta、Yokosawa Masahiro、Furuyama Kotona、Miki Haruka、Tahara‐Hanaoka Satoko、Shibuya Akira、Tsuboi Hiroto、Goto Daisuke、Matsumoto Isao、Shibayama Shiro、Sumida Takayuki
  • Journal Title: International Journal of Rheumatic Diseases Volume: 21 Pages: 2071-2078
  • DOI: 10.1111/1756-185X.13381
  • Peer Reviewed
• [Journal Article] Exploring the Gut Fungi-Lung Allergy Axis (2018)
  • Author(s): Shibuya Akira、Shibuya Kazuko
  • Journal Title: Cell Host & Microbe Volume: 24 Pages: 755～757
  • DOI: 10.1016/j.chom.2018.11.012
  • Peer Reviewed
• [Journal Article] Elovl6 regulates mechanical damage-induced keratinocyte death and skin inflammation (2018)
  • Author(s): Nakamura Yoshiyuki、Matsuzaka Takashi、Tahara-Hanaoka Satoko、Shibuya Kazuko、Shimano Hitoshi、Nakahashi-Oda Chigusa、Shibuya Akira
  • Journal Title: Cell Death & Disease Volume: 9 Pages: 1181
  • DOI: 10.1038/s41419-018-1226-1
  • Peer Reviewed
• [Journal Article] Forebrain Ptf1a Is Required for Sexual Differentiation of the Brain (2018)
  • Author(s): Fujiyama Tomoyuki、Miyashita Satoshi、Tsuneoka Yousuke、Kanemaru Kazumasa、Kakizaki Miyo、Kanno Satomi、Ishikawa Yukiko、Yamashita Mariko、Owa Tomoo、Nagaoka Mai、Kawaguchi Yoshiya、Yanagawa Yuchio、Magnuson Mark A.、Muratani Masafumi、Shibuya Akira、Nabeshima Yo-ichi、Yanagisawa Masashi、Funato Hiromasa、Hoshino Mikio
  • Journal Title: Cell Reports Volume: 24 Pages: 79～94
  • DOI: 10.1016/j.celrep.2018.06.010
  • Peer Reviewed
• [Journal Article] Glycoprotein nmb is exposed on the surface of dormant breast cancer cells and induces stem cell-like properties (2018)
  • Author(s): Chen Chen、Okita Yukari、Watanabe Yukihide、Abe Fumie、Fikry Muhammad Ali、Ichikawa Yumu、Suzuki Hiroyuki、Shibuya Akira、Kato Mitsuyasu
  • Journal Title: Cancer Research Volume: 78 Pages: 6424-6435
  • DOI: 10.1158/0008-5472.CAN-18-0599
  • Peer Reviewed
• [Journal Article] Selective DNAM-1 expression on small peritoneal macrophages contributes to CD4+ T cell costimulation (2018)
  • Author(s): Takenaka Eri、Van Vo Anh、Yamashita-Kanemaru Yumi、Shibuya Akira、Shibuya Kazuko
  • Journal Title: Scientific Reports Volume: 8 Pages: 15180
  • DOI: 10.1038/s41598-018-33437-4
  • Peer Reviewed
• [Journal Article] Cutting Edge: Identification of Marginal Reticular Cells as Phagocytes of Apoptotic B Cells in Germinal Centers (2018)
  • Author(s): Sato Kazuki、Honda Shin-ichiro、Shibuya Akira、Shibuya Kazuko
  • Journal Title: The Journal of Immunology Volume: 200 Pages: 3691～3696
  • DOI: 10.4049/jimmunol.1701293
  • Peer Reviewed
• [Journal Article] TX99 Is a Neutralizing Monoclonal Antibody Against Mouse TIGIT (2018)
  • Author(s): Nakamura Yuho、Naito Keisuke、Yamashita-Kanemaru Yumi、Komori Daisuke、Hirochika Rei、Shibuya Akira、Shibuya Kazuko
  • Journal Title: Monoclonal Antibodies in Immunodiagnosis and Immunotherapy Volume: 37 Pages: 105～109
  • DOI: 10.1089/mab.2018.0001
  • Peer Reviewed
• [Journal Article] Serum selenoprotein P, but not selenium, predicts future hyperglycemia in a general Japanese population (2018)
  • Author(s): Oo Swe Mar、Misu Hirofumi、Saito Yoshiro、Tanaka Mutsumi、Kato Seiji、Kita Yuki、Takayama Hiroaki、Takeshita Yumie、Kanamori Takehiro、Nagano Toru、Nakagen Masatoshi、Urabe Takeshi、Matsuyama Naoto、Kaneko Shuichi、Takamura Toshinari
  • Journal Title: Scientific Reports Volume: 8 Pages: 16727
  • DOI: 10.1038/s41598-018-35067-2
  • Peer Reviewed
• [Journal Article] Comparison of Human Selenoprotein P Determinants in Serum between Our Original Methods and Commercially Available Kits (2018)
  • Author(s): Saito Yoshiro、Misu Hirofumi、Takayama Hiroaki、Takashima Shin-ichiro、Usui Soichiro、Takamura Masayuki、Kaneko Shuichi、Takamura Toshinari、Noguchi Noriko
  • Journal Title: Biological and Pharmaceutical Bulletin Volume: 41 Pages: 828～832
  • DOI: 10.1248/bpb.b18-00046
  • Peer Reviewed
• [Journal Article] Inhibin βE (INHBE) is a possible insulin resistance-associated hepatokine identified by comprehensive gene expression analysis in human liver biopsy samples (2018)
  • Author(s): Sugiyama Masakazu、Kikuchi Akihiro、Misu Hirofumi、Igawa Hirobumi、Ashihara Motooki、Kushima Youichi、Honda Kiyofumi、Suzuki Yoshiyuki、Kawabe Yoshiki、Kaneko Shuichi、Takamura Toshinari
  • Journal Title: PLOS ONE Volume: 13 Pages: e0194798
  • DOI: 10.1371/journal.pone.0194798
  • Peer Reviewed
• [Journal Article] Endogenous Selenoprotein P, a Liver-Derived Secretory Protein, Mediates Myocardial Ischemia/Reperfusion Injury in Mice (2018)
  • Author(s): Chadani Hiroshi、Usui Soichiro、Inoue Oto、Kusayama Takashi、Takashima Shin-ichiro、Kato Takeshi、Murai Hisayoshi、Furusho Hiroshi、Nomura Ayano、Misu Hirofumi、Takamura Toshinari、Kaneko Shuichi、Takamura Masayuki
  • Journal Title: International Journal of Molecular Sciences Volume: 19 Pages: 878～878
  • DOI: 10.3390/ijms19030878
  • Peer Reviewed
• [Journal Article] Light alcohol consumption has the potential to suppress hepatocellular injury and liver fibrosis in non-alcoholic fatty liver disease (2018)
  • Author(s): Yamada Kazutoshi、Mizukoshi Eishiro、Seike Takuya、Horii Rika、Kitahara Masaaki、Sunagozaka Hajime、Arai Kuniaki、Yamashita Tatsuya、Honda Masao、Kaneko Shuichi
  • Journal Title: PLOS ONE Volume: 13 Pages: e0191026
  • DOI: 10.1371/journal.pone.0191026
  • Peer Reviewed
• [Journal Article] Sirt2 facilitates hepatic glucose uptake by deacetylating glucokinase regulatory protein (2018)
  • Author(s): Watanabe Hitoshi、Inaba Yuka、Kimura Kumi、Matsumoto Michihiro、Kaneko Shuichi、Kasuga Masato、Inoue Hiroshi
  • Journal Title: Nature Communications Volume: 9 Pages: 30
  • DOI: 10.1038/s41467-017-02537-6
  • Peer Reviewed
• [Journal Article] Asymmetric Integration of Single-Cell Transcriptomic Data using Latent Dirichlet Allocation and Procrustes Analysis (2018)
  • Author(s): Eto Mitsuhiro、Hirota Wataru、Seno Shigeto、Matsuda Hideo
  • Journal Title: IEEE International Conference on Bioinformatics and Biomedicin Volume: - Pages: 2129-2135
  • DOI: 10.1109/bibm.2018.8621115
  • Peer Reviewed
• [Journal Article] Regnase-1 controls colon epithelial regeneration via regulation of mTOR and purine metabolism (2018)
  • Author(s): Nagahama Yasuharu、Shimoda Mayuko、Mao Guoliang、Singh Shailendra Kumar、Kozakai Yuuki、Sun Xin、Motooka Daisuke、Nakamura Shota、Tanaka Hiroki、Satoh Takashi、Maeda Kazuhiko、Akira Shizuo
  • Journal Title: Proceedings of the National Academy of Sciences Volume: 115 Pages: 11036～11041
  • DOI: 10.1073/pnas.1809575115
  • Peer Reviewed
• [Journal Article] Infection with flaviviruses requires BCLXL for cell survival (2018)
  • Author(s): Suzuki Tatsuya、Okamoto Toru、Katoh Hiroshi、Sugiyama Yukari、Kusakabe Shinji、Tokunaga Makoto、Hirano Junki、Miyata Yuka、Fukuhara Takasuke、Ikawa Masahito、Satoh Takashi、Yoshio Sachiyo、Suzuki Ryosuke、Saijo Masayuki、Huang David C. S.、Kanto Tatsuya、Akira Shizuo、Matsuura Yoshiharu
  • Journal Title: PLOS Pathogens Volume: 14 Pages: e1007299
  • DOI: 10.1371/journal.ppat.1007299
  • Peer Reviewed
• [Journal Article] Electrophilic properties of itaconate and derivatives regulate the?IκBζ?ATF3 inflammatory axis (2018)
  • Author(s): Bambouskova M, Gorvel L, Lampropoulou V, Sergushichev A, Loginicheva E, Johnson K, Korenfeld D, Mathyer ME, Kim H, Huang LH, Duncan D, Bregman H, Keskin A, Santeford A, Apte RS, Sehgal R, Johnson B, Amarasinghe GK, Soares MP, Satoh T.
  • Journal Title: Nature Volume: 556 Pages: 501～504
  • DOI: 10.1038/s41586-018-0052-z
  • Peer Reviewed
• [Journal Article] BATF2 activates DUSP2 gene expression and up-regulates NF-κB activity via phospho-STAT3 dephosphorylation (2018)
  • Author(s): Kanemaru Hisashi、Yamane Fumihiro、Tanaka Hiroki、Maeda Kazuhiko、Satoh Takashi、Akira Shizuo
  • Journal Title: International Immunology Volume: 30 Pages: 255～265
  • DOI: 10.1093/intimm/dxy023
  • Peer Reviewed
• [Journal Article] Sulindac sulfone inhibits the mTORC1 pathway in colon cancer cells by directly targeting voltage-dependent anion channel 1 and 2 (2018)
  • Author(s): Aono Yuichi、Horinaka Mano、Iizumi Yosuke、Watanabe Motoki、Taniguchi Tomoyuki、Yasuda Shusuke、Sakai Toshiyuki
  • Journal Title: Biochemical and Biophysical Research Communications Volume: 505 Pages: 1203～1210
  • DOI: 10.1016/j.bbrc.2018.10.050
  • Peer Reviewed
• [Journal Article] Mevalonate pathway blockage enhances the efficacy of mTOR inhibitors with the activation of retinoblastoma protein in renal cell carcinoma (2018)
  • Author(s): Hagiwara Nobuhisa、Watanabe Motoki、Iizuka-Ohashi Mahiro、Yokota Isao、Toriyama Seijiro、Sukeno Mamiko、Tomosugi Mitsuhiro、Sowa Yoshihiro、Hongo Fumiya、Mikami Kazuya、Soh Jintetsu、Fujito Akira、Miyashita Hiroaki、Morioka Yukako、Miki Tsuneharu、Ukimura Osamu、Sakai Toshiyuki
  • Journal Title: Cancer Letters Volume: 431 Pages: 182～189
  • DOI: 10.1016/j.canlet.2018.05.025
  • Peer Reviewed
• [Journal Article] Blockage of the mevalonate pathway overcomes the apoptotic resistance to MEK inhibitors with suppressing the activation of Akt in cancer cells (2018)
  • Author(s): Iizuka-Ohashi Mahiro、Watanabe Motoki、Sukeno Mamiko、Morita Mie、Hoang Ngoc Thi Hong、Kuchimaru Takahiro、Kizaka-Kondoh Shinae、Sowa Yoshihiro、Sakaguchi Koichi、Taguchi Tetsuya、Sakai Toshiyuki
  • Journal Title: Oncotarget Volume: 9 Pages: 19597-19612
  • DOI: 10.18632/oncotarget.24696
  • Peer Reviewed
• [Journal Article] Reinforce the antitumor activity of CD8+ T cells via glutamine restriction (2018)
  • Author(s): Nabe Shogo、Yamada Takeshi、Suzuki Junpei、Toriyama Koji、Yasuoka Toshiaki、Kuwahara Makoto、Shiraishi Atsushi、Takenaka Katsuto、Yasukawa Masaki、Yamashita Masakatsu
  • Journal Title: Cancer Science Volume: 109 Pages: 3737～3750
  • DOI: 10.1111/cas.13827
  • Peer Reviewed
• [Journal Article] The tumor suppressor menin prevents effector CD8 T-cell dysfunction by targeting mTORC1-dependent metabolic activation (2018)
  • Author(s): Suzuki Junpei、Yamada Takeshi、Inoue Kazuki、Nabe Shogo、Kuwahara Makoto、Takemori Nobuaki、Takemori Ayako、Matsuda Seiji、Kanoh Makoto、Imai Yuuki、Yasukawa Masaki、Yamashita Masakatsu
  • Journal Title: Nature Communications Volume: 9 Pages: 3296
  • DOI: 10.1038/s41467-018-05854-6
  • Peer Reviewed
• [Journal Article] Three-step transcriptional priming that drives the commitment of multipotent progenitors toward B cells (2018)
  • Author(s): Miyai Tomohiro、Takano Junichiro、Endo Takaho A.、Kawakami Eiryo、Agata Yasutoshi、Motomura Yasutaka、Kubo Masato、Kashima Yukie、Suzuki Yutaka、Kawamoto Hiroshi、Ikawa Tomokatsu
  • Journal Title: Genes & Development Volume: 32 Pages: 112～126
  • DOI: 10.1101/gad.309575.117
  • Peer Reviewed
• [Journal Article] GITR cosignal in ILC2s controls allergic lung inflammation (2018)
  • Author(s): Nagashima Hiroyuki、Okuyama Yuko、Fujita Tsuyoshi、Takeda Takeo、Motomura Yasutaka、Moro Kazuyo、Hidaka Takanori、Omori Koki、Sakurai Tsuyoshi、Machiyama Tomoaki、Ndhlovu Lishomwa C.、Riccardi Carlo、So Takanori、Ishii Naoto
  • Journal Title: Journal of Allergy and Clinical Immunology Volume: 141 Pages: 1939～1943.e8
  • DOI: 10.1016/j.jaci.2018.01.028
  • Peer Reviewed
• [Journal Article] Proteomics analysis identified peroxiredoxin 2 involved in early-phase left ventricular impairment in hamsters with cardiomyopathy (2018)
  • Author(s): Kuzuya Kentaro、Ichihara Sahoko、Suzuki Yuka、Inoue Chisa、Ichihara Gaku、Kurimoto Syota、Oikawa Shinji
  • Journal Title: PLOS ONE Volume: 13 Pages: e0192624
  • DOI: 10.1371/journal.pone.0192624
  • Peer Reviewed
• [Journal Article] The DNA methylation profile of liver tumors in C3H mice and identification of differentially methylated regions involved in the regulation of tumorigenic genes (2018)
  • Author(s): Matsushita Junya、Okamura Kazuyuki、Nakabayashi Kazuhiko、Suzuki Takehiro、Horibe Yu、Kawai Tomoko、Sakurai Toshihiro、Yamashita Satoshi、Higami Yoshikazu、Ichihara Gaku、Hata Kenichiro、Nohara Keiko
  • Journal Title: BMC Cancer Volume: 18 Pages: 317
  • DOI: 10.1186/s12885-018-4221-0
  • Peer Reviewed
• [Journal Article] Pulmonary hypofunction due to calcium carbonate nanomaterial exposure in occupational workers: a cross-sectional study (2018)
  • Author(s): Li Guoliang、Liang Lihong、Yang Jingchao、Zeng Lihai、Xie Zhiwei、Zhong Yizhou、Ruan Xiaolin、Dong Ming、Yang Zhanhong、Lai Guanchao、Huang Weixin、Yang Aichu、Chen Jiabing、Wu Banghua、Xu Huaming、Meng Dezhi、Hu Shijie、Xia Lihua、Yang Xingfen、Li Laiyu、Ichihara Sahoko、Ichihara Gaku、Huang Hanlin、Huang Zhenlie
  • Journal Title: Nanotoxicology Volume: 12 Pages: 571～585
  • DOI: 10.1080/17435390.2018.1465606
  • Peer Reviewed
• [Journal Article] Exposure to 1,2-Dichloropropane Upregulates the Expression of Activation-Induced Cytidine Deaminase (AID) in Human Cholangiocytes Co-Cultured With Macrophages (2018)
  • Author(s): Zong Cai、Kimura Yusuke、Kinoshita Kazuo、Takasu Shigetada、Zhang Xiao、Sakurai Toshihiro、Sekido Yoshitaka、Ichihara Sahoko、Endo Ginji、Ichihara Gaku
  • Journal Title: Toxicological Sciences Volume: 168 Pages: 137～148
  • DOI: 10.1093/toxsci/kfy280
  • Peer Reviewed
• [Journal Article] Occupational Exposure Limits for ethylidene norbornene, ethyleneimine, benomyl, and 2,3-epoxypropyl methacrylate, and classifications on carcinogenicity (2018)
  • Author(s): Committee for Recommendation of Occupational Exposure Limits, Japan Society for Occupational Health, Araki A, Azuma K, Endo G, Endo Y, Fukushima T, Hara K, Hori H, Horie S, Horiguchi H, Ichiba M, Ichihara G, Ikeda M, Ishitake T, Ito A, Ito Y, Iwasawa S, Kakumu T, Kamijima M, Karita K.
  • Journal Title: Journal of Occupational Health Volume: 60 Pages: 333～335
  • DOI: 10.1539/joh.2018-0137-OP
  • Peer Reviewed
• [Journal Article] Carcinogenicity of isobutyl nitrite, β-picoline, and some acrylates (2018)
  • Author(s): Kromhout H, Friesen M, Marques MM, Sergi CM, Abdallah M, Benke G, Cesta M, Germolec D, Houck K, Ichihara G, Jameson CW, Kanno J, Pogribny I, Svendsen C, Benbrahim-Tallaa L, Guyton KZ, Grosse Y, El Ghissassi F, Bouvard V, Hall A.
  • Journal Title: The Lancet Oncology Volume: 19 Pages: 1020～1022
  • DOI: 10.1016/S1470-2045(18)30491-1
  • Peer Reviewed
• [Journal Article] Familial episodic limb pain in kindreds with novel Nav1.9 mutations (2018)
  • Author(s): Kabata R, Okuda H, Noguchi A, Kondo D, Fujiwara M, Hata K, Kato Y, Ishikawa K, Tanaka M, Sekine Y, Hishikawa N, Mizukami T, Ito J, Akasaka M, Sakurai K, Yoshida T, Minoura H, Hayashi T, Inoshita K, Matsuyama M, Kinjo N, Cao Y, Inoue S, Kobayashi H, Harada KH, Youssefian S, Takahashi T, Koizumi A.
  • Journal Title: PLOS ONE Volume: 13 Pages: e0208516
  • DOI: 10.1371/journal.pone.0208516
  • Peer Reviewed
• [Journal Article] Rare variants in RNF213, a susceptibility gene for moyamoya disease, are found in patients with pulmonary hypertension and aggravate hypoxia-induced pulmonary hypertension in mice (2018)
  • Author(s): Kobayashi Hatasu、Kabata Risako、Kinoshita Hideyuki、Morimoto Takaaki、Ono Koh、Takeda Midori、Choi Jungmi、Okuda Hiroko、Liu Wanyang、Harada Kouji H.、Kimura Takeshi、Youssefian Shohab、Koizumi Akio
  • Journal Title: Pulmonary Circulation Volume: 8 Pages: 204589401877815
  • DOI: 10.1177/2045894018778155
  • Peer Reviewed
• [Journal Article] Dysregulation of RNF213 promotes cerebral hypoperfusion (2018)
  • Author(s): Morimoto Takaaki、Enmi Jun-ichiro、Hattori Yorito、Iguchi Satoshi、Saito Satoshi、Harada Kouji H.、Okuda Hiroko、Mineharu Yohei、Takagi Yasushi、Youssefian Shohab、Iida Hidehiro、Miyamoto Susumu、Ihara Masafumi、Kobayashi Hatasu、Koizumi Akio
  • Journal Title: Scientific Reports Volume: 8 Pages: 3607
  • DOI: 10.1038/s41598-018-22064-8
  • Peer Reviewed
• [Journal Article] β-cell-specific overexpression of adiponectin receptor 1 does not improve diabetes mellitus in Akita mice (2018)
  • Author(s): Choi Jungmi、Kobayashi Hatasu、Okuda Hiroko、Harada Kouji H.、Takeda Midori、Fujimoto Hiroyuki、Yamane Shunsuke、Tanaka Daisuke、Youssefian Shohab、Inagaki Nobuya、Koizumi Akio
  • Journal Title: PLOS ONE Volume: 13 Pages: e0190863
  • DOI: 10.1371/journal.pone.0190863
  • Peer Reviewed
• [Journal Article] Protein Residue Networks from Energetic and Geometric Data: Are They Identical? (2018)
  • Author(s): Sladek Vladimir、Tokiwa Hiroaki、Shimano Hitoshi、Shigeta Yasuteru
  • Journal Title: Journal of Chemical Theory and Computation Volume: 14 Pages: 6623～6631
  • DOI: 10.1021/acs.jctc.8b00733
  • Peer Reviewed
• [Journal Article] Network meta-analysis of the relative efficacy of bariatric surgeries for diabetes remission (2018)
  • Author(s): Kodama S.、Fujihara K.、Horikawa C.、Harada M.、Ishiguro H.、Kaneko M.、Furukawa K.、Matsubayashi Y.、Matsunaga S.、Shimano H.、Tanaka S.、Kato K.、Sone H.
  • Journal Title: Obesity Reviews Volume: 19 Pages: 1621～1629
  • DOI: 10.1111/obr.12751
  • Peer Reviewed
• [Journal Article] Relationship between intake of fruit separately from vegetables and triglycerides - A meta-analysis (2018)
  • Author(s): Kodama Satoru、Horikawa Chika、Fujihara Kazuya、Ishii Dai、Hatta Mariko、Takeda Yasunaga、Kitazawa Masaru、Matsubayashi Yasuhiro、Shimano Hitoshi、Kato Kiminori、Tanaka Shiro、Sone Hirohito
  • Journal Title: Clinical Nutrition ESPEN Volume: 27 Pages: 53～58
  • DOI: 10.1016/j.clnesp.2018.07.001
  • Peer Reviewed
• [Journal Article] The Peroxisome Proliferator-Activated Receptor α (PPARα) Agonist Pemafibrate Protects against Diet-Induced Obesity in Mice (2018)
  • Author(s): Araki Masaya、Nakagawa Yoshimi、Oishi Asayo、Han Song-iee、Wang Yunong、Kumagai Kae、Ohno Hiroshi、Mizunoe Yuhei、Iwasaki Hitoshi、Sekiya Motohiro、Matsuzaka Takashi、Shimano Hitoshi
  • Journal Title: International Journal of Molecular Sciences Volume: 19 Pages: 2148～2148
  • DOI: 10.3390/ijms19072148
  • Peer Reviewed
• [Journal Article] Brg1 regulates pro-lipogenic transcription by modulating SREBP activity in hepatocytes (2018)
  • Author(s): Li Nan、Li Min、Hong Wenxuan、Shao Jing、Xu Huihui、Shimano Hitoshi、Lu Jun、Xu Yong
  • Journal Title: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease Volume: 1864 Pages: 2881～2889
  • DOI: 10.1016/j.bbadis.2018.05.022
  • Peer Reviewed
• [Journal Article] Malondialdehyde-modified LDL-related variables are associated with diabetic kidney disease in type 2 diabetes (2018)
  • Author(s): Furukawa Shoko、Suzuki Hiroaki、Fujihara Kazuya、Kobayashi Kazuto、Iwasaki Hitoshi、Sugano Yoko、Yatoh Shigeru、Sekiya Motohiro、Yahagi Naoya、Shimano Hitoshi
  • Journal Title: Diabetes Research and Clinical Practice Volume: 141 Pages: 237～243
  • DOI: 10.1016/j.diabres.2018.05.019
  • Peer Reviewed
• [Journal Article] CREBH Regulates Systemic Glucose and Lipid Metabolism (2018)
  • Author(s): Nakagawa Yoshimi、Shimano Hitoshi
  • Journal Title: International Journal of Molecular Sciences Volume: 19 Pages: 1396～1396
  • DOI: 10.3390/ijms19051396
  • Peer Reviewed
• [Journal Article] Evaluation of safety for hepatectomy in a novel mouse model with nonalcoholic-steatohepatitis (2018)
  • Author(s): Ozawa Yusuke、Tamura Takafumi、Owada Yohei、Shimizu Yoshio、Kemmochi Akira、Hisakura Katsuji、Matsuzaka Takashi、Shimano Hitoshi、Isoda Hiroko、Ohkohchi Nobuhiro
  • Journal Title: World Journal of Gastroenterology Volume: 24 Pages: 1622～1631
  • DOI: 10.3748/wjg.v24.i15.1622
  • Peer Reviewed
• [Journal Article] Transgenic Mice Overexpressing SREBP-1a in Male ob/ob Mice Exhibit Lipodystrophy and Exacerbate Insulin Resistance (2018)
  • Author(s): Ohno Hiroshi、Matsuzaka Takashi、Tang Nie、Sharma Rahul、Motomura Kaori、Shimura Takuya、Satoh Aoi、Han Song-iee、Takeuchi Yoshinori、Aita Yuichi、Iwasaki Hitoshi、Yatoh Shigeru、Suzuki Hiroaki、Sekiya Motohiro、Nakagawa Yoshimi、Sone Hirohito、Yahagi Naoya、Yamada Nobuhiro、Higami Yoshikazu、Shimano Hitoshi
  • Journal Title: Endocrinology Volume: 159 Pages: 2308～2323
  • DOI: 10.1210/en.2017-03179
  • Peer Reviewed
• [Journal Article] Molecular association model of PPARα and its new specific and efficient ligand, pemafibrate: Structural basis for SPPARMα (2018)
  • Author(s): Yamamoto Yuta、Takei Kenta、Arulmozhiraja Sundaram、Sladek Vladimir、Matsuo Naoya、Han Song-iee、Matsuzaka Takashi、Sekiya Motohiro、Tokiwa Takaki、Shoji Mitsuo、Shigeta Yasuteru、Nakagawa Yoshimi、Tokiwa Hiroaki、Shimano Hitoshi
  • Journal Title: Biochemical and Biophysical Research Communications Volume: 499 Pages: 239～245
  • DOI: 10.1016/j.bbrc.2018.03.135
  • Peer Reviewed
• [Journal Article] Saturated Fatty Acids Undergo Intracellular Crystallization and Activate the NLRP3 Inflammasome in Macrophages (2018)
  • Author(s): Karasawa Tadayoshi、Kawashima Akira、Usui-Kawanishi Fumitake、Watanabe Sachiko、Kimura Hiroaki、Kamata Ryo、Shirasuna Koumei、Koyama Yutaro、Sato-Tomita Ayana、Matsuzaka Takashi、Tomoda Hiroshi、Park Sam-Yong、Shibayama Naoya、Shimano Hitoshi、Kasahara Tadashi、Takahashi Masafumi
  • Journal Title: Arteriosclerosis, Thrombosis, and Vascular Biology Volume: 38 Pages: 744～756
  • DOI: 10.1161/ATVBAHA.117.310581
  • Peer Reviewed
• [Journal Article] Epigenetic modulation of Fgf21 in the perinatal mouse liver ameliorates diet-induced obesity in adulthood (2018)
  • Author(s): Yuan Xunmei、Tsujimoto Kazutaka、Hashimoto Koshi、Kawahori Kenichi、Hanzawa Nozomi、Hamaguchi Miho、Seki Takami、Nawa Makiko、Ehara Tatsuya、Kitamura Yohei、Hatada Izuho、Konishi Morichika、Itoh Nobuyuki、Nakagawa Yoshimi、Shimano Hitoshi、Takai-Igarashi Takako、Kamei Yasutomi、Ogawa Yoshihiro
  • Journal Title: Nature Communications Volume: 9 Pages: 636
  • DOI: 10.1038/s41467-018-03038-w
  • Peer Reviewed
• [Journal Article] Age-dependent changes in dynamic standing-balance ability evaluated quantitatively using a stabilometer (2018)
  • Author(s): Suzuki Yasuhiro、Yatoh Shigeru、Suzuki Hiroaki、Tanabe Yuuki、Shimizu Yukiyo、Hada Yasushi、Shimano Hitoshi
  • Journal Title: Journal of Physical Therapy Science Volume: 30 Pages: 86～91
  • DOI: 10.1589/jpts.30.86
  • Peer Reviewed
• [Journal Article] A candidate functional SNP rs7074440 in TCF7L2 alters gene expression through C-FOS in hepatocytes (2018)
  • Author(s): Piao X, Yahagi N, Takeuchi Y, Aita Y, Murayama Y, Sawada Y, Shikama A, Masuda Y, Nishi-Tatsumi M, Kubota M, Izumida Y, Sekiya M, Matsuzaka T, Nakagawa Y, Sugano Y, Iwasaki H, Kobayashi K, Yatoh S, Suzuki H, Yagyu H, Kawakami Y, Shimano H.
  • Journal Title: FEBS Letters Volume: 592 Pages: 422～433
  • DOI: 10.1002/1873-3468.12975
  • Peer Reviewed
• [Journal Article] A Rare Coexistence of Pheochromocytoma and Parkinson's Disease With Diagnostic Challenges (2018)
  • Author(s): Matsumura-Matsuda Erika、Sekiya Motohiro、Omoto-Inuzuka Miyoko、Santo Kana、Shikama Akito、Kuba Motoko、Sugano Yoko、Iwasaki Hitoshi、Yatoh Shigeru、Sato Taiki、Hara Hisato、Takekoshi Kazuhiro、Suzuki Hiroaki、Shimano Hitoshi
  • Journal Title: Internal Medicine Volume: 57 Pages: 979～985
  • DOI: 10.2169/internalmedicine.9242-17
  • Peer Reviewed
• [Journal Article] Relationships among cardiorespiratory fitness, muscular fitness, and cardiometabolic risk factors in Japanese adolescents: Niigata screening for and preventing the development of non-communicable disease study-Agano (NICE EVIDENCE Study-Agano) 2 (2018)
  • Author(s): Morikawa Sakiko Yoshizawa、Fujihara Kazuya、Hatta Mariko、Osawa Taeko、Ishizawa Masahiro、Yamamoto Masahiko、Furukawa Kazuo、Ishiguro Hajime、Matsunaga Satoshi、Ogawa Yohei、Shimano Hitoshi、Sone Hirohito
  • Journal Title: Pediatric Diabetes Volume: 19 Pages: 593～602
  • DOI: 10.1111/pedi.12623
  • Peer Reviewed
• [Journal Article] Monopoiesis in humans and mice (2018)
  • Author(s): Kawamura Shunsuke、Ohteki Toshiaki
  • Journal Title: International Immunology Volume: 30 Pages: 503-509
  • DOI: 10.1093/intimm/dxy063
  • Peer Reviewed
• [Journal Article] IFN-γ-dependent epigenetic regulation instructs colitogenic monocyte/macrophage lineage differentiation in vivo (2018)
  • Author(s): Nakanishi Y、Sato T、Takahashi K、Ohteki T
  • Journal Title: Mucosal Immunology Volume: 11 Pages: 871～880
  • DOI: 10.1038/mi.2017.104
  • Peer Reviewed
• [Journal Article] Macrophages in inflammation, repair and regeneration (2018)
  • Author(s): Oishi Yumiko、Manabe Ichiro
  • Journal Title: International Immunology Volume: 30 Pages: 511-528
  • DOI: 10.1093/intimm/dxy054
  • Peer Reviewed
• [Journal Article] Does the prenatal bisphenol A exposure alter DNA methylation levels in the mouse hippocampus?: An analysis using a high-sensitivity methylome technique (2018)
  • Author(s): Aiba Toshiki、Saito Toshiyuki、Hayashi Akiko、Sato Shinji、Yunokawa Harunobu、Maruyama Toru、Fujibuchi Wataru、Ohsako Seiichiroh
  • Journal Title: Genes and Environment Volume: 40 Pages: 12
  • DOI: 10.1186/s41021-018-0099-y
  • Peer Reviewed
• [Journal Article] Detection of dioxin-induced demethylation of mouse Cyp1a1 gene promoter by a new labeling method for short DNA fragments possessing 5'-methylcytosine at the end (2018)
  • Author(s): Kurita Hisaka、Aiba Toshiki、Saito Toshiyuki、Ohsako Seiichiroh
  • Journal Title: Genes and Environment Volume: 40 Pages: 1
  • DOI: 10.1186/s41021-017-0089-5
  • Peer Reviewed
• [Journal Article] Expression of Xenobiotic Biomarkers CYP1 Family in Preputial Tissue of Patients with Hypospadias and Phimosis and Its Association with DNA Methylation Level of SRD5A2 Minimal Promoter (2018)
  • Author(s): Ohsako Seiichiroh、Aiba Toshiki、Miyado Mami、Fukami Maki、Ogata Tsutomu、Hayashi Yutaro、Mizuno Kentaro、Kojima Yoshiyuki
  • Journal Title: Archives of Environmental Contamination and Toxicology Volume: 74 Pages: 240～247
  • DOI: 10.1007/s00244-017-0466-x
  • Peer Reviewed
• [Journal Article] Lung fibroblasts express a miR-19a-19b-20a sub-cluster to suppress TGF-β-associated fibroblast activation in murine pulmonary fibrosis (2018)
  • Author(s): Souma Kunihiko、Shichino Shigeyuki、Hashimoto Shinichi、Ueha Satoshi、Tsukui Tatsuya、Nakajima Takuya、Suzuki Hiroshi I.、Shand Francis H. W.、Inagaki Yutaka、Nagase Takahide、Matsushima Kouji
  • Journal Title: Scientific Reports Volume: 8 Pages: 16642
  • DOI: 10.1038/s41598-018-34839-0
  • Peer Reviewed
• [Journal Article] STAM-binding protein regulates melanoma metastasis through SLUG stabilization (2018)
  • Author(s): Iwakami Yusuke、Yokoyama Satoru、Watanabe Kensuke、Hayakawa Yoshihiro
  • Journal Title: Biochemical and Biophysical Research Communications Volume: 507 Pages: 484～488
  • DOI: 10.1016/j.bbrc.2018.11.068
  • Peer Reviewed
• [Journal Article] Lung-resident natural killer cells control pulmonary tumor growth in mice (2018)
  • Author(s): Yamamoto Yutaka、Miyazato Kiho、Takahashi Kei、Yoshimura Naoki、Tahara Hideaki、Hayakawa Yoshihiro
  • Journal Title: Cancer Science Volume: 109 Pages: 2670～2676
  • DOI: 10.1111/cas.13703
  • Peer Reviewed
• [Journal Article] A Gata3 3′ Distal Otic Vesicle Enhancer Directs Inner Ear-Specific Gata3 Expression (2018)
  • Author(s): Moriguchi Takashi、Hoshino Tomofumi、Rao Arvind、Yu Lei、Takai Jun、Uemura Satoshi、Ise Kazue、Nakamura Yasuhiro、Lim Kim-Chew、Shimizu Ritsuko、Yamamoto Masayuki、Engel James Douglas
  • Journal Title: Molecular and Cellular Biology Volume: 38 Pages: e00302-18
  • DOI: 10.1128/MCB.00302-18
  • Peer Reviewed
• [Journal Article] Satellite RNA Increases DNA Damage and Accelerates Tumor Formation in Mouse Models of Pancreatic Cancer (2018)
  • Author(s): Kishikawa Takahiro、Otsuka Motoyuki、Suzuki Tatsunori、Seimiya Takahiro、Sekiba Kazuma、Ishibashi Rei、Tanaka Eri、Ohno Motoko、Yamagami Mari、Koike Kazuhiko
  • Journal Title: Molecular Cancer Research Volume: 16 Pages: 1255～1262
  • DOI: 10.1158/1541-7786.MCR-18-0139
  • Peer Reviewed
• [Journal Article] MicroRNA-7: a potent suppressor of the malignant potential of hepatocellular carcinoma (2018)
  • Author(s): Otsuka Motoyuki、Tanaka Eri、Sekiba Kazuma、Seimiya Takahiro、Yamagami Mari、Koike Kazuhiko
  • Journal Title: Non-coding RNA Investigation Volume: 2 Pages: 30～30
  • DOI: 10.21037/ncri.2018.05.04
  • Peer Reviewed
• [Journal Article] Hepatitis B virus pathogenesis: Fresh insights into hepatitis B virus RNA (2018)
  • Author(s): Sekiba Kazuma、Otsuka Motoyuki、Ohno Motoko、Yamagami Mari、Kishikawa Takahiro、Suzuki Tatsunori、Ishibashi Rei、Seimiya Takahiro、Tanaka Eri、Koike Kazuhiko
  • Journal Title: World Journal of Gastroenterology Volume: 24 Pages: 2261～2268
  • DOI: 10.3748/wjg.v24.i21.2261
  • Peer Reviewed
• [Journal Article] DHX9 regulates production of hepatitis B virus-derived circular RNA and viral protein levels (2018)
  • Author(s): Sekiba Kazuma、Otsuka Motoyuki、Ohno Motoko、Kishikawa Takahiro、Yamagami Mari、Suzuki Tatsunori、Ishibashi Rei、Seimiya Takahiro、Tanaka Eri、Koike Kazuhiko
  • Journal Title: Oncotarget Volume: 9 Pages: 20953-20964
  • DOI: 10.18632/oncotarget.25104
  • Peer Reviewed
• [Journal Article] β-Glucans in food modify colonic microflora by inducing antimicrobial protein, calprotectin, in a Dectin-1-induced-IL-17F-dependent manner (2018)
  • Author(s): Kamiya T、Tang C、Kadoki M、Oshima K、Hattori M、Saijo S、Adachi Y、Ohno N、Iwakura Y
  • Journal Title: Mucosal Immunology Volume: 11 Pages: 763～773
  • DOI: 10.1038/mi.2017.86
  • Peer Reviewed
• [Journal Article] Suppression of IL-17F, but not of IL-17A, provides protection against colitis by inducing Treg cells through modification of the intestinal microbiota (2018)
  • Author(s): Tang Ce、Kakuta Shigeru、Shimizu Kenji、Kadoki Motohiko、Kamiya Tomonori、Shimazu Tomoyuki、Kubo Sachiko、Saijo Shinobu、Ishigame Harumichi、Nakae Susumu、Iwakura Yoichiro
  • Journal Title: Nature Immunology Volume: 19 Pages: 755～765
  • DOI: 10.1038/s41590-018-0134-y
  • Peer Reviewed
• [Journal Article] Effects of high fructose intake on liver injury progression in high fat diet induced fatty liver disease in ovariectomized female mice (2018)
  • Author(s): Ohashi Tomoko、Kato Masaki、Yamasaki Akihiro、Kuwano Akifumi、Suzuki Hideo、Kohjima Motoyuki、Ogawa Yoshihiro
  • Journal Title: Food and Chemical Toxicology Volume: 118 Pages: 190～197
  • DOI: 10.1016/j.fct.2018.05.006
  • Peer Reviewed
• [Journal Article] Obeticholic acid protects against hepatocyte death and liver fibrosis in a murine model of nonalcoholic steatohepatitis (2018)
  • Author(s): Goto Toshihiro、Itoh Michiko、Suganami Takayoshi、Kanai Sayaka、Shirakawa Ibuki、Sakai Takeru、Asakawa Masahiro、Yoneyama Toshihiro、Kai Toshihiro、Ogawa Yoshihiro
  • Journal Title: Scientific Reports Volume: 8 Pages: 8157
  • DOI: 10.1038/s41598-018-26383-8
  • Peer Reviewed
• [Journal Article] Efficient identification of compounds suppressing protein precipitation via solvent screening using serial deletion mutants of the target protein (2018)
  • Author(s): Yunoki Kaori、Yoshinaga Sosuke、Takeda Mitsuhiro、Nagano Ryohei、Tsuchiya Yusuke、Sonoda Akihiro、Tsuji Tatsuichiro、Hirakane Makoto、Toda Etsuko、Terashima Yuya、Matsushima Kouji、Terasawa Hiroaki
  • Journal Title: Genes to Cells Volume: 23 Pages: 70～79
  • DOI: 10.1111/gtc.12554
  • Peer Reviewed
• [Journal Article] Single blood transfusion induces the production of donor-specific alloantibodies and regulatory T cells mainly in the spleen (2018)
  • Author(s): Ueta Hisashi、Kitazawa Yusuke、Sawanobori Yasushi、Ueno Takamasa、Ueha Satoshi、Matsushima Kouji、Matsuno Kenjiro
  • Journal Title: International Immunology Volume: 30 Pages: 53～67
  • DOI: 10.1093/intimm/dxx078
  • Peer Reviewed
• [Journal Article] Increased diversity with reduced “diversity evenness” of tumor infiltrating T-cells for the successful cancer immunotherapy (2018)
  • Author(s): Hosoi Akihiro、Takeda Kazuyoshi、Nagaoka Koji、Iino Tamaki、Matsushita Hirokazu、Ueha Satoshi、Aoki Shin、Matsushima Kouji、Kubo Masato、Morikawa Teppei、Kitaura Kazutaka、Suzuki Ryuji、Kakimi Kazuhiro
  • Journal Title: Scientific Reports Volume: 8 Pages: 1058
  • DOI: 10.1038/s41598-018-19548-y
  • Peer Reviewed
• [Journal Article] NK Cells Control Tumor-Promoting Function of Neutrophils in Mice (2018)
  • Author(s): Ogura Keisuke、Sato-Matsushita Marimo、Yamamoto Seiji、Hori Takashi、Sasahara Masakiyo、Iwakura Yoichiro、Saiki Ikuo、Tahara Hideaki、Hayakawa Yoshihiro
  • Journal Title: Cancer Immunology Research Volume: 6 Pages: 348～357
  • DOI: 10.1158/2326-6066.CIR-17-0204
  • Peer Reviewed
• [Journal Article] Single blood transfusion induces the production of donor-specific alloantibodies and regulatory T cells mainly in the spleen. (2018)
  • Author(s): Ueta H, Kitazawa Y, Sawanobori Y, Ueno T, Ueha S, Matsushima K, Matsuno K.
  • Journal Title: Int Immunol Volume: 8 Pages: 53-67
  • DOI: doi: 101093/intimm/dxx078
  • Peer Reviewed / Open Access
• [Journal Article] Dysregulation of RNF213 promotes cerebral hypoperfusion. (2018)
  • Author(s): Morimoto T, Enmi JI, Hattori Y, Iguchi S, Saito S, Harada KH, Okuda H, Mineharu Y, Takagi Y, Youssefian S, Iida H, Miyamoto S, Ihara M, Kobayashi H, Koizumi A.
  • Journal Title: Sci Rep Volume: 26 Pages: 3607
  • DOI: doi: 101038/s41598-018-22064-8
  • Peer Reviewed / Open Access
• [Journal Article] Correction to Synthesis of Potent and Selective Inhibitors of Aldo-Keto Reductase 1B10 and Their Efficacy against Proliferation, Metastasis, and Cisplatin Resistance of Lung Cancer Cells. (2018)
  • Author(s): Endo S, Xia S, Suyama M, Morikawa Y, Oguri H, Hu D, Ao Y, Takahara S, Horino Y, Hayakawa Y, Watanabe Y, Gouda H, Hara A, Kuwata K, Toyooka N, Matsunaga T, Ikari A.
  • Journal Title: J Med Chem Volume: 8 Pages: 1380
  • DOI: doi: 101021/acs.jmedchem.7b01911
  • Peer Reviewed / Open Access
• [Journal Article] Expression of Xenobiotic Biomarkers CYP1 Family in Preputial Tissue of Patients with Hypospadias and Phimosis and Its Association with DNA Methylation Level of SRD5A2 Minimal Promoter. (2018)
  • Author(s): Ohsako S, Aiba T, Miyado M, Fukami M, Ogata T, Hayashi Y, Mizuno K, Kojima Y.
  • Journal Title: Arch Environ Contam Toxicol Volume: 74(2) Pages: 240-247
  • DOI: doi: 101007/s00244-017-0466-x
  • Peer Reviewed / Open Access
• [Journal Article] Efficient identification of compounds suppressing protein precipitation via solvent screening using serial deletion mutants of the target protein. (2018)
  • Author(s): Yunoki K, Yoshinaga S, Takeda M, Nagano R, Tsuchiya Y, Sonoda A, Tsuji T, Hirakane M, Toda E, Terashima Y, Matsushima K, Terasawa H.
  • Journal Title: Genes Cells Volume: 23(2) Pages: 70-79
  • DOI: doi: 101111/gtc.12554
  • Peer Reviewed / Open Access
• [Journal Article] NK Cells Control Tumor-Promoting Function of Neutrophils in Mice. (2018)
  • Author(s): Ogura K, Sato-Matsushita M, Yamamoto S, Hori T, Sasahara M, Iwakura Y, Saiki I, Tahara H, Hayakawa Y.
  • Journal Title: Cancer Immunol Res Volume: 23 Pages: in press
  • DOI: doi: 101158/2326-6066.CIR-17-0204.
  • Peer Reviewed / Open Access
• [Journal Article] Increased diversity with reduced "diversity evenness" of tumor infiltrating T-cells for the successful cancer immunotherapy. (2018)
  • Author(s): Hosoi A, Takeda K, Nagaoka K, Iino T, Matsushita H, Ueha S, Aoki S, Matsushima K, Kubo M, Morikawa T, Kitaura K, Suzuki R, Kakimi K.
  • Journal Title: Sci Rep Volume: 18 Pages: 1058
  • DOI: doi: 101038/s41598-018-19548-y
  • Peer Reviewed / Open Access
• [Journal Article] The Dark Side of IFN-g: Its Role in Promoting Cancer Immunoevasion. (2017)
  • Author(s): Mojic M, Takeda K, Hayakawa Y.
  • Journal Title: Int J Mol Sci Volume: 28 Pages: 1-13
  • DOI: pii: E89 doi: 10.3390/ijms19010089.
  • Peer Reviewed
• [Journal Article] Long-Lasting Graft-Derived Donor T Cells Contribute to the Pathogenesis of Chronic Graft-versus-Host Disease in Mice. (2017)
  • Author(s): Kosugi-Kanaya M, Ueha S, Abe J, Shichino S, Shand FHW, Morikawa T, Kurachi M, Shono Y, Sudo N, Yamashita A, Suenaga F, Yokoyama A, Yong W, Imamura M, Teshima T, Matsushima K.
  • Journal Title: Front Immunol Volume: 18 Pages: 1-14
  • DOI: doi: 103389/fimmu.2017.1842
  • Peer Reviewed / Open Access
• [Journal Article] ASK1 facilitates tumor metastasis through phosphorylation of an ADP receptor P2Y(12) in platelets. (2017)
  • Author(s): Kamiyama M, Shirai T, Tamura S, Suzuki-Inoue K, Ehata S, Takahashi K, Miyazono K, Hayakawa Y, Sato T, Takeda K, Naguro I, Ichijo H.
  • Journal Title: Cell Death Differ Volume: 24(12) Pages: 2066-2076
  • DOI: doi: 101038/cdd.2017.114
  • Peer Reviewed
• [Journal Article] The CD45(+) fraction in murine adipose tissue derived stromal cells harbors immune-inhibitory inflammatory cells. (2017)
  • Author(s): Nasti A, Sakai Y, Seki A, Buffa GB, Komura T, Mochida H, Yamato M, Yoshida K, Ho TTB, Takamura M, Usui S, Wada T, Honda M, Kaneko S.
  • Journal Title: Eur J Immunol Volume: 47(12) Pages: 2163-2174
  • DOI: doi: 101002/eji.201646835
  • Peer Reviewed
• [Journal Article] Effect of sodium-glucose cotransporter 2 (SGLT2) inhibition on weight loss is partly mediated by liver-brain-adipose neurocircuitry. (2017)
  • Author(s): Sawada Y, Izumida Y, Takeuchi Y, Aita Y, Wada N, Li E, Murayama Y, Piao X, Shikama A, Masuda Y, Nishi-Tatsumi M, Kubota M, Sekiya M, Matsuzaka T, Nakagawa Y, Sugano Y, Iwasaki H, Kobayashi K, Yatoh S, Suzuki H, Yagyu H, Kawakami Y, et al.
  • Journal Title: Biochem Biophys Res Commun Volume: 4 Pages: 40-45
  • DOI: doi: 101016/j.bbrc.2017.9.81
  • Peer Reviewed
• [Journal Article] Ribosomal protein S3 regulates XIAP expression independently of the NF-ホコB pathway in breast cancer cells. (2017)
  • Author(s): Ono H, Iizumi Y, Goi W, Sowa Y, Taguchi T, Sakai T.
  • Journal Title: Oncol Rep Volume: 38(5) Pages: 3205-3210
  • DOI: doi: 103892/or.2017.6008.
  • Peer Reviewed
• [Journal Article] Report of the International Stem Cell Banking Initiative Workshop Activity: Current Hurdles and Progress in Seed-Stock Banking of Human Pluripotent Stem Cells. (2017)
  • Author(s): Kim JH, Kurtz A, Yuan BZ, Zeng F, Lomax G, Loring JF, Crook J, Ju JH, Clarke L, Inamdar MS, Pera M, Firpo MT, Sheldon M, Rahman N, O'Shea O, Pranke P, Zhou Q, Isasi R, Rungsiwiwut R, Kawamata S, Oh S, Ludwig T, et al.
  • Journal Title: Stem Cells Transl Med Volume: 6(11) Pages: 1956-1962
  • DOI: doi: 101002/sctm.17-0144.
  • Peer Reviewed
• [Journal Article] Comprehensive single-cell transcriptome analysis reveals heterogeneity in endometrioid adenocarcinoma tissues. (2017)
  • Author(s): Hashimoto S, Tabuchi Y, Yurino H, Hirohashi Y, Deshimaru S, Asano T, Mariya T, Oshima K, Takamura Y, Ukita Y, Ametani A, Kondo N, Monma N, Takeda T, Misu S, Okayama T, Ikeo K, Saito T, Kaneko S, Suzuki Y, Hattori M, Matsushima K, et al.
  • Journal Title: Sci Rep Volume: 27 Pages: 14225
  • DOI: doi: 101038/s41598-017-14676-3.
  • Peer Reviewed / Open Access
• [Journal Article] Gene expression profiling of hepatocarcinogenesis in a mouse model of chronic hepatitis B. (2017)
  • Author(s): Nosaka T, Naito T, Hiramatsu K, Ohtani M, Nemoto T, Marusawa H, Ma N, Hiraku Y, Kawanishi S, Yamashita T, Kaneko S, Nakamoto Y.
  • Journal Title: PLoS One Volume: 2 Pages: e0185442
  • DOI: doi: 101371/journal.pone.185442
  • Peer Reviewed / Open Access
• [Journal Article] Combination of anti-CD4 antibody treatment and donor lymphocyte infusion ameliorates graft-versus-host disease while preserving graft-versus-tumor effects in murine allogeneic hematopoietic stem cell transplantation. (2017)
  • Author(s): Ueha S, Yokochi S, Ishiwata Y, Kosugi-Kanaya M, Shono Y, Shibayama S, Ito S, Matsushima K.
  • Journal Title: Cancer Sci Volume: 108(10) Pages: 1967-1973
  • DOI: doi: 101111/cas.13346
  • Peer Reviewed / Open Access
• [Journal Article] Long non-coding RNA HOTAIR promotes cell migration by upregulating insulin growth factor-binding protein 2 in renal cell carcinoma. (2017)
  • Author(s): Katayama H, Tamai K, Shibuya R, Nakamura M, Mochizuki M, Yamaguchi K, Kawamura S, Tochigi T, Sato I, Okanishi T, Sakurai K, Fujibuchi W, Arai Y, Satoh K.
  • Journal Title: Sci Rep Volume: 20 Pages: 12016
  • DOI: doi: 101038/s41598-017-12191-z.
  • Peer Reviewed / Open Access
• [Journal Article] Proteasome Inhibitor-Loaded Micelles Enhance Antitumor Activity Through Macrophage Reprogramming by NF-ホコB Inhibition. (2017)
  • Author(s): Wu H, Tao A, Martin JD, Quader S, Liu X, Takahashi K, Hespel L, Miura Y, Hayakawa Y, Irimura T, Cabral H, Kataoka K.
  • Journal Title: J Pharm Sci Volume: 106(9) Pages: 2438-2446
  • DOI: doi: 101016/j.xphs.2017.3.31
  • Peer Reviewed
• [Journal Article] Optimized retroviral transduction of mouse T cells for in vivo assessment of gene function. (2017)
  • Author(s): Kurachi M, Kurachi J, Chen Z, Johnson J, Khan O, Bengsch B, Stelekati E, Attanasio J, McLane LM, Tomura M, Ueha S, Wherry EJ.
  • Journal Title: Nat Protoc Volume: 12(9) Pages: 1980-1998
  • DOI: doi: 101038/nprot.2017.83.
  • Peer Reviewed
• [Journal Article] RNF213 p.R4810K Variant and Intracranial Arterial Stenosis or Occlusion in Relatives of Patients with Moyamoya Disease. (2017)
  • Author(s): Matsuda Y, Mineharu Y, Kimura M, Takagi Y, Kobayashi H, Hitomi T, Harada KH, Uchihashi Y, Funaki T, Miyamoto S, Koizumi A.
  • Journal Title: J Stroke Cerebrovasc Dis Volume: 26(8) Pages: 1841-1847
  • DOI: doi: 101016/j.jstrokecerebrovasdis.2017.4.19
  • Peer Reviewed
• [Journal Article] Occupational exposure limits for ethylene glycol monobutyl ether, isoprene, isopropyl acetate and propyleneimine, and classifications on carcinogenicity, occupational sensitizer and reproductive toxicant. (2017)
  • Author(s): Committee for Recommendation of Occupational Exposure Limits, Japan Society for Occupational Health., Azuma K, Endo G, Endo Y, Fukushima T, Hara K, Hori H, Horie S, Horiguchi H, Ichiba M, Ichihara G, Ikeda M, Ishitake T, Ito A, Ito Y, Iwasawa S, Kamijima M, Karita K, Katoh T, Kawai T, Kawamoto T, Kishi R, et al.
  • Journal Title: J Occup Health Volume: 27 Pages: 364-366
  • DOI: doi: 101539/joh.17-0148-OP.
  • Peer Reviewed
• [Journal Article] Elovl6 Deficiency Improves Glycemic Control in Diabetic db/db Mice by Expanding ホイ-Cell Mass and Increasing Insulin Secretory Capacity. (2017)
  • Author(s): Zhao H, Matsuzaka T, Nakano Y, Motomura K, Tang N, Yokoo T, Okajima Y, Han SI, Takeuchi Y, Aita Y, Iwasaki H, Yatoh S, Suzuki H, Sekiya M, Yahagi N, Nakagawa Y, Sone H, Yamada N, Shimano H.
  • Journal Title: Diabetes Volume: 66(7) Pages: 1833-1846
  • DOI: doi: 102337/db16-1277.
  • Peer Reviewed
• [Journal Article] CoptidisツRhizoma induces intrinsic apoptosis through BAX and BAK activation in human melanoma. (2017)
  • Author(s): Xu X, Yokoyama S, Hayakawa Y, Saiki I.
  • Journal Title: Oncol Rep Volume: 38(1) Pages: 538-544
  • DOI: doi: 103892/or.2017.5672
  • Peer Reviewed / Open Access
• [Journal Article] Microarray analyses of otospheres derived from the cochlea in the inner ear identify putative transcription factors that regulate the characteristics of otospheres. (2017)
  • Author(s): Iki T, Tanaka M, Kitajiri SI, Kita T, Kawasaki Y, Mizukoshi A, Fujibuchi W, Nakagawa T, Nakahata T, Ito J, Omori K, Saito MK.
  • Journal Title: PLoS One Volume: 12(6) Pages: e0179901
  • DOI: doi: 101371/journal.pone.179901
  • Peer Reviewed / Open Access
• [Book] 脂質メディエーターによるマスト細胞とアレルギー炎症の制御, アレルギーの臨床, 41 (2) (2021)
  • Author(s): 村上誠
  • Total Pages: 13-16
  • Publisher: 北隆館
• [Book] ＴＨＥ創薬 -少資源国家にっぽんの生きる道- (2021)
  • Author(s): 酒井敏行
  • Total Pages: 63-77
  • Publisher: 薬事日報社
• [Book] 脂質とアレルギー疾患, アレルギー, 69 (4) (2020)
  • Author(s): 村上誠
  • Total Pages: 250-255
  • Publisher: 一般社団法人 日本アレルギー学会
• [Book] 腸内細菌代謝産物による腎臓病の治療薬開発, ヒトマイクロバイオーム, Vol.2 (2020)
  • Author(s): 岩田恭宜・中出祐介・和田隆志
  • Total Pages: 361-365
  • Publisher: エヌ・ティー・エス
• [Remarks]
  • URL: http://inflammationcellularsociology.org/
• [Remarks] 予防を科学する炎症細胞社会学ホームページ
  • URL: http://inflammationcellularsociology.org/
• [Remarks] 新学術領域研究 予防を科学する炎症細胞社会学 ホームページ
  • URL: http://inflammationcellularsociology.org/
• [Funded Workshop] 文部科学省新学術領域研究 予防を科学する炎症細胞社会学 1st International Symposium on Inflammation Cellular Sociology（第1回国際シンポジウム） (2019)