Preventive medicine through inflammation cellular sociology

• Project Area: Preventive medicine through inflammation cellular sociology
• Project/Area Number: 17H06391
• Research Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
• Allocation Type: Single-year Grants
• Review Section: Complex systems
• Research Institution: Tokyo University of Science (2018-2019); The University of Tokyo (2017)
• Principal Investigator: 松島 綱治 東京理科大学, 研究推進機構生命医科学研究所, 教授 (50222427)
• Co-Investigator(Kenkyū-buntansha): 橋本 真一 金沢大学, 医薬保健学総合研究科, 特任教授 (00313099)
• Project Period (FY): 2017-06-30 – 2022-03-31
• Project Status: Granted (Fiscal Year 2019)
• Budget Amount: ¥196,560,000 (Direct Cost: ¥151,200,000、Indirect Cost: ¥45,360,000); Fiscal Year 2020: ¥33,150,000 (Direct Cost: ¥25,500,000、Indirect Cost: ¥7,650,000); Fiscal Year 2019: ¥33,150,000 (Direct Cost: ¥25,500,000、Indirect Cost: ¥7,650,000); Fiscal Year 2018: ¥33,150,000 (Direct Cost: ¥25,500,000、Indirect Cost: ¥7,650,000); Fiscal Year 2017: ¥63,960,000 (Direct Cost: ¥49,200,000、Indirect Cost: ¥14,760,000)
• Keywords: 免疫 / 遺伝子 / 情報工学 / モデル化 / 病理学

Outline of Annual Research Achievements

本総括班研究では、包括的single-cell transcriptome、遺伝子発現データ解析、エピゲノム解析、プロテオーム解析、リピドーム解析、マイクロバイオーム解析、遺伝子組換え動物作製を支援する炎症細胞社会解析センターを設置し、領域横断で使用可能な炎症細胞社会の解析プラットフォームを整備し、環境 ストレス、ゲノム社会予防医学、脂質代謝生化学、循環器・肝臓・腎臓臨床医学、分子標的予防医学、計算生物学など多様なバックグランドを持つ研究者の連携を強力に促進することを目的としている。今年度は、オンラインコラボレーションソフトウェアSLACKを通じて情報解析支援チームと計画研究班、公募研究班の連携体制を強化した。また、各計画研究班、公募研究班の疾患モデル解析について、解析対象の設定から単細胞懸濁液の調製、調整した細胞サンプルのquality controlを含めた支援体制を構築し、包括的single-cell transcriptome支援をすすめた。これまでに肺、肝臓、腎臓、膵臓、腸管などの炎症疾患モデルについて包括的single-cell transcriptomeを行い、データを取得している。班会議や共同研究推進委員会などを通じて領域内での情報交換や共同研究を推進するとともに、公開シンポジウムや一般向けの科学コミュニケーション活動「免疫ふしぎ未来」を通じて本学術領域の広報活動を行った。

Current Status of Research Progress

2: Research has progressed on the whole more than it was originally planned.

Reason

昨年度構築した様々なオミックス解析支援体制を強化し、また単一細胞懸濁液の調製が困難な臓器の炎症疾患モデル解析については、細胞調製の段階から支援する体制を整えた。これにより、領域内で取得する炎症細胞社会データの質が安定し、疾患横断的な議論が可能になった。

Strategy for Future Research Activity

引き続き、各計画研究、公募研究を支援する。領域の運営方針、研究支援内容は、年2回開催する班会議にて主に策定するが、必要に応じて随時委員会を開催し、領域代表(総括班研究代表者)の承認のもと、柔軟に対応する。1) Single-cell transcriptome: Nx-1マイクロウェルデバイスおよびRhapsodyシステムを用い、固有のバーコードを持つ1細胞由来cDNA libraryを数千個の細胞について作成し、次世代シーケンサーを用いて各細胞の遺伝子発現情報を取得する。2）　遺伝子発現データ解析: 発現変動遺伝子抽出、GO解析、クラスター解析、パスウェイ解析などを支援する。3） エピゲノム解析: MSD-AFLP法などを用いたDNAメチル化解析、ChIP-seqなどによるヒストン修飾解析を支援する。4) プロテオーム解析: 蛍光標識2次元ディファレンスゲル電気泳動解析システムと質量分析装置(TOF-MS)を用いて標的タンパク質の同定を支援する。 5) リピドーム解析: 液体クロマトグラフィーと三連四重極型質量分析計(TripleQ)を組み合わせたLC-MS/MS、ならびに四重極飛行時間型質量分析計(Q-TOF)を用いて、リピドーム解析を支援する。6) マイクロバイオーム解析: 次世代シーケンサーを用いて、細菌叢の16S rRNA遺伝子配列に基づく網羅的解析を行い、腸内 細菌叢遺伝子情報解析を支援する。7) 遺伝子組換え動物作製支援: CRISPR/Cas9などの遺伝子編集技術を用いて、ノックアウトマウス、レポーターマウスの作製を支援する。

Research Products

• [Journal Article] Inhibition of HBV Transcription From cccDNA With Nitazoxanide by Targeting the HBx?DDB1 Interaction (2019)
  • Author(s): Sekiba Kazuma、Otsuka Motoyuki、Ohno Motoko、Yamagami Mari、Kishikawa Takahiro、Suzuki Tatsunori、Ishibashi Rei、Seimiya Takahiro、Tanaka Eri、Koike Kazuhiko
  • Journal Title: Cellular and Molecular Gastroenterology and Hepatology Volume: 7 Pages: 297-312
  • DOI: 10.1016/j.jcmgh.2018.10.010
  • Peer Reviewed / Open Access
• [Journal Article] TAK1 Prevents Endothelial Apoptosis and Maintains Vascular Integrity (2019)
  • Author(s): Naito H, Iba T, Wakabayashi T, Tai-Nagara I, Suehiro JI, Jia W, Eino D, Sakimoto S, Muramatsu F, Kidoya H, Sakurai H, Satoh T, Akira S, Kubota Y, Takakura N.
  • Journal Title: Developmental Cell Volume: 48 Pages: 151-166
  • DOI: 10.1016/j.devcel.2018.12.002
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Isozyme-Specific Role of SAD-A in Neuronal Migration During Development of Cerebral Cortex. (2019)
  • Author(s): Nakanishi K, Niida H, Tabata H, Ito T, Hori Y, Hattori M, Johmura Y, Yamada C, Ueda T, Takeuchi K, Yamada K, Nagata KI, Wakamatsu N, Kishi M, Pan YA, Ugawa S, Shimada S, Sanes JR, Higashi Y, Nakanishi M.
  • Journal Title: Cerebral Cortex Volume: 160 Pages: 1-14
  • DOI: 10.1093/cercor/bhy253
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Role of interleukin-17 in a murine community-associated methicillin-resistant Staphylococcus aureus pneumonia model. (2019)
  • Author(s): Shibue Yasushi、Kimura Soichiro、Kajiwara Chiaki、Iwakura Yoichiro、Yamaguchi Keizo、Tateda Kazuhiro
  • Journal Title: Microbes and infection Volume: 21 Pages: 33-39
  • DOI: 10.1016/j.micinf.2018.06.006
  • Peer Reviewed / Open Access
• [Journal Article] Dectin-2?Mediated Signaling Leads to Delayed Skin Wound Healing through Enhanced Neutrophilic Inflammatory Response and Neutrophil Extracellular Trap Formation (2019)
  • Author(s): Miura T, Kawakami K, Tada H (5番目), Tachi M. (員数19).
  • Journal Title: The Journal of investigative dermatology Volume: 139(3) Pages: 702-711
  • DOI: 10.1016/j.jid.2018.10.015
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Dectin-1 Contributes to Myocardial Ischemia/Reperfusion Injury by Regulating Macrophage Polarization and Neutrophil Infiltration. (2019)
  • Author(s): Fan Qin、Tao Rong、Zhang Hang、Xie Hongyang、Lu Lin、Wang Ting、Su Min、Hu Jian、Zhang Qi、Chen Qiujing、Iwakura Yoichiro、Shen Weifeng、Zhang Ruiyan、Yan Xiaoxiang
  • Journal Title: Circulation Volume: 139 Pages: 663-678
  • DOI: 10.1161/circulationaha.118.036044
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Circulating Concentrations of Insulin Resistance-Associated Hepatokines, Selenoprotein P and Leukocyte Cell-Derived Chemotaxin 2, during an Oral Glucose Tolerance Test in Humans (2019)
  • Author(s): Mohri K, Misu H, Takayama H, Ishii KA, Kikuchi A, Lan F, Enyama Y, Takeshita Y, Saito Y, Kaneko S,Takamura T.
  • Journal Title: Biol. Pharm. Bull. Volume: 42 Issue: 3 Pages: 373-378
  • DOI: 10.1248/bpb.b18-00549
  • NAID: 130007607371
  • ISSN: 0918-6158, 1347-5215
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Higher pulse pressure predicts initiation of dialysis in Japanese patients with diabetes (2019)
  • Author(s): Osawa T, Fujihara K, Harada M, Yamamoto M, Ishizawa M, Suzuki H, Ishiguro H, Matsubayashi Y, Seida H, Yamanaka N, Tanaka S, Shimano H, Kodama S, Sone H
  • Journal Title: Diabetes/Metabolism Research and Reviews Volume: 35
  • DOI: 10.1002/dmrr.3120
  • Peer Reviewed
• [Journal Article] Mesenchymal-Epithelial Interactome Analysis Reveals Essential Factors Required for Fibroblast-Free Alveolosphere Formation. (2019)
  • Author(s): Shiraishi Kazushige、Shichino Shigeyuki、Ueha Satoshi、Nakajima Takuya、Hashimoto Shinichi、Yamazaki Satoshi、Matsushima Kouji
  • Journal Title: iScience. Volume: 11 Pages: 318-333
  • DOI: 10.1016/j.isci.2018.12.022
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] ISGF3 with reduced phosphorylation is associated with constitutive expression of interferon-induced genes in aging cells (2018)
  • Author(s): Yamagami Mari、Otsuka Motoyuki、Kishikawa Takahiro、Sekiba Kazuma、Seimiya Takahiro、Tanaka Eri、Suzuki Tatsunori、Ishibashi Rei、Ohno Motoko、Koike Kazuhiko
  • Journal Title: npj Aging and Mechanisms of Disease Volume: 4 Pages: 11-11
  • DOI: 10.1038/s41514-018-0030-6
  • Peer Reviewed / Open Access
• [Journal Article] Inflammation and de-differentiation in pancreatic carcinogenesis (2018)
  • Author(s): Seimiya Takahiro、Otsuka Motoyuki、Iwata Takuma、Tanaka Eri、Suzuki Tatsunori、Sekiba Kazuma、Yamagami Mari、Ishibashi Rei、Koike Kazuhiko
  • Journal Title: World Journal of Clinical Cases Volume: 6 Pages: 882-891
  • DOI: 10.12998/wjcc.v6.i15.882
  • Peer Reviewed / Open Access
• [Journal Article] Angiopoietin-2 exacerbates cardiac hypoxia and inflammation after myocardial infarction (2018)
  • Author(s): Lee Seung-Jun、Lee Choong-kun、Kang Seok、Park Intae、Kim Yoo Hyung、Kim Seo Ki、Hong Seon Pyo、Bae Hosung、He Yulong、Kubota Yoshiaki、Koh Gou Young
  • Journal Title: Journal of Clinical Investigation Volume: 128 Pages: 5018-5033
  • DOI: 10.1172/jci99659
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Hematopoietic insults damage bone marrow niche by activating p53 in vascular endothelial cells (2018)
  • Author(s): Si S, Nakajima-Takagi Y, Iga T, Tsuji M, Hou L, Oshima M, Koide S, Saraya A, Yamazaki S, Takubo K, Kubota Y, Minamino T, Iwama A.
  • Journal Title: Exp Hematol. Volume: 63 Pages: 41-51
  • DOI: 10.1016/j.exphem.2018.04.006
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Degradation of the endoplasmic reticulum?anchored transcription factor MyRF by the ubiquitin ligase SCFFbxw7in a manner dependent on the kinase GSK-3 (2018)
  • Author(s): Nakayama S, Yumimoto K, Kawamura A, Nakayama KI.
  • Journal Title: Journal of Biological Chemistry Volume: 293(15) Pages: 5705-5714
  • DOI: 10.1074/jbc.ra117.000741
  • Peer Reviewed
• [Journal Article] Efficient Generation of Small Intestinal Epithelial-like Cells from Human iPSCs for Drug Absorption and Metabolism Studies. (2018)
  • Author(s): Negoro Ryosuke、Takayama Kazuo、Kawai Kanae、Harada Kazuo、Sakurai Fuminori、Hirata Kazumasa、Mizuguchi Hiroyuki
  • Journal Title: Stem Cell Reports. Volume: 11 Pages: 1539-1550
  • DOI: 10.1016/j.stemcr.2018.10.019
  • Peer Reviewed / Open Access
• [Journal Article] Fbxo22-mediated KDM4B degradation determines selective estrogen receptor modulator activity in breast cancer. (2018)
  • Author(s): Johmura Y, Maeda I, Suzuki N, Wu W, Goda A, Morita M, Yamaguchi K, Yamamoto M, Nagasawa S, Kojima Y, Tsugawa K, Inoue N, Miyoshi Y, Osako T, Akiyama F, Maruyama R, Inoue JI, Furukawa Y, Ohta T, Nakanishi M.
  • Journal Title: Jounal of Clinical Investigation Volume: 128 Issue: 12 Pages: 5603-5619
  • DOI: 10.1172/jci121679
  • Peer Reviewed / Open Access
• [Journal Article] Production of low-molecular weight soluble yeast β-glucan by an acid degradation method. (2018)
  • Author(s): Ishimoto Yuina、Ishibashi Ken-ichi、Yamanaka Daisuke、Adachi Yoshiyuki、Kanzaki Ken、Iwakura Yoichiro、Ohno Naohito
  • Journal Title: International journal of biological macromolecules Volume: 107 Pages: 2269-2278
  • DOI: 10.1016/j.ijbiomac.2017.10.094
  • Peer Reviewed / Open Access
• [Journal Article] IL-1R2 deficiency suppresses dextran sodium sulfate-induced colitis in mice via regulation of microbiota (2018)
  • Author(s): Yoshida, K., Murayama, M., Shimizu, K., Tang, C., Katagiri, N., Matsuo, K., Fukai F., and Iwakura, Y.
  • Journal Title: Biochemical and biophysical research communications Volume: 496 Pages: 934-940
  • DOI: 10.1016/j.bbrc.2018.01.116
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] HER2 Overexpression Triggers an IL1-α Pro-inflammatory Circuit to Drive Tumorigenesis and Promote Chemotherapy Resistance. (2018)
  • Author(s): Liu, S., Lee, J. S., Jie, C., Park, M. H., Iwakura, Y., Patel, Y., Soni, M., Reisman, D., and Chen, H.
  • Journal Title: Cancer research Volume: - Pages: 2040-2051
  • DOI: 10.1158/0008-5472.can-17-2761
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Establishment and analysis of a novel mouse line carrying a conditional knockin allele of a cancer-specific FBXW7 mutation (2018)
  • Author(s): Ikenoue T, Terakado Y, Zhu C, Liu X, Ohsugi T, Matsubara D, Fujii T, Kakuta S,Kubo S, Shibata T, Yamaguchi K, Iwakura Y, Furukawa Y.
  • Journal Title: Scientific reports Volume: 8 Pages: 2021-2021
  • DOI: 10.1038/s41598-018-19769-1
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Myeloid-derived interleukin-1β drives oncogenic KRAS-NF-NF-κB addiction in malignant pleural effusion. (2018)
  • Author(s): Marazioti A, Lilis I, Vreka M, Apostolopoulou H, Kalogeropoulou A, Giopanou I, Giotopoulou GA, Krontira AC, Iliopoulou M, Kanellakis NI, Agalioti T, Giannou AD, Jones-Paris C, Iwakura Y, Kardamakis D, Blackwell TS, Taraviras S, Spella M, Stathopoulos GT.
  • Journal Title: Nature communications Volume: 9 Pages: 672-672
  • DOI: 10.1038/s41467-018-03051-z
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Host defense against oral microbiota by bone-damaging T cells (2018)
  • Author(s): Masayuki Tsukasaki, Noriko Komatsu, Kazuki Nagashima, Takeshi Nitta, Warunee Pluemsakunthai, Chisa Shukunami, Yoichiro Iwakura, Tomoki Nakashima, Kazuo Okamoto, and Hiroshi Takayanagi
  • Journal Title: Nat Commun Volume: 9 Pages: 701-701
  • DOI: 10.1038/s41467-018-03147-6
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Increased mTOR cancels out the effect of reduced Xbp-1 on antibody secretion in IL-1α deficient B cells. (2018)
  • Author(s): Zhu Gaizhi、Liu Xiaoling、Fang Ying、Zhai Bing、Xu Ruonan、Han Gencheng、Chen Guojiang、Xiao He、Hou Chunmei、Shen Beifen、Li Yan、Iwakura Yoichiro、Wang Liang、Jiang Zhenyu、Ma Ning、Liu Guangchao、Wang Renxi
  • Journal Title: Cellular immunology Volume: 328 Pages: 9-17
  • DOI: 10.1016/j.cellimm.2018.02.015
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] IL-25 enhances Th17 cell-mediated contact dermatitis by promoting IL-1β production by dermal dendreitic cells. (2018)
  • Author(s): Suto H, Nambu A, Morita H, Yamaguchi S, Numata T, Yoshizaki T, Shimura E, Arae K, Asada Y, Motomura K, Kaneko M, Abe T, Matsuda A, Iwakura Y, Okumura K, Saito H, Matsumoto K, Sudo K, Nakae S
  • Journal Title: J. Allergy Clin. Immunol Volume: In press Pages: 1500-1509
  • DOI: 10.1016/j.jaci.2017.12.1007
  • Peer Reviewed / Open Access
• [Journal Article] Apaf1 plays a negative regulatory role in T cell responses by suppressing activation of antigen-stimulated T cells (2018)
  • Author(s): Tong, H., Miyake, Y., Mi-Ichi, F., Iwakura, Y., Hara, H. and Yoshida, H.
  • Journal Title: PloS one Volume: 13 Pages: 0195119-0195119
  • DOI: 10.1371/journal.pone.0195119
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] A model of TH17-associated ileal hyperplasia that requires both IL-17A and IFN-γ to generate self-tolerance and prevent colitis. (2018)
  • Author(s): Jeschke Jonathan C.、Mayne Christopher G.、Ziegelbauer Jennifer、DeCiantis Christopher L.、Singh Selina、Kumar Suresh N.、Suchi Mariko、Iwakura Yoichiro、Drobyski William R.、Salzman Nita H、Williams Calvin B.
  • Journal Title: Mucosal immunology Volume: 11 Pages: 1127-1137
  • DOI: 10.1038/s41385-018-0023-6
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] IL-36α from Skin-Resident Cells Plays an Important Role in the Pathogenesis of Imiquimod-Induced Psoriasiform Dermatitis by Forming a Local Autoamplification Loop (2018)
  • Author(s): Hashiguchi Y, Yabe R, Chung SH, Murayama MA, Yoshida K, Matsuo K, Kubo S, Saijo S, Nakamura Y, Matsue H, Iwakura Y.
  • Journal Title: Journal of immunology (Baltimore, Md. : 1950) Volume: 201 Pages: 167-182
  • DOI: 10.4049/jimmunol.1701157
  • Peer Reviewed / Open Access
• [Journal Article] Inhibition of interleukin-1 suppresses angiotensin II-induced aortic inflammation and aneurysm formation (2018)
  • Author(s): Isoda K, Akita K, Kitamura K, Sato-Okabayashi Y, Kadoguchi T, Isobe S, Ohtomo F, Sano M, Shimada K, Iwakura Y, Daida H
  • Journal Title: International Journal of Cardiology Volume: 270 Pages: 221-227
  • DOI: 10.1016/j.ijcard.2018.05.072
  • Peer Reviewed / Open Access
• [Journal Article] BAFF inhibition attenuates fibrosis in scleroderma by modulating the regulatory and effector B cell balance. (2018)
  • Author(s): Matsushita Takashi、Kobayashi Tadahiro、Mizumaki Kie、Kano Miyu、Sawada Tomoyo、Tennichi Momoko、Okamura Ai、Hamaguchi Yasuhito、Iwakura Yoichiro、Hasegawa Minoru、Fujimoto Manabu、Takehara Kazuhiko
  • Journal Title: Science advances Volume: 4 Pages: 9944-9944
  • DOI: 10.1126/sciadv.aas9944
  • Peer Reviewed / Open Access
• [Journal Article] MAIT cells protect against pulmonary Legionella longbeachae infection. (2018)
  • Author(s): Wang H, D'Souza C, Lim XY, Kostenko L, Pediongco TJ, Eckle SBG, Meehan BS, Shi M, Wang N, Li S, Liu L, Mak JYW, Fairlie DP, Iwakura Y, Gunnersen JM, Stent AW, Godfrey DI, Rossjohn J, Westall GP, Kjer-Nielsen L, Strugnell RA, McCluskey J, Corbett AJ, Hinks TSC, Chen Z.
  • Journal Title: Nature communications Volume: 9 Pages: 3350-3350
  • DOI: 10.1038/s41467-018-05202-8
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] The ATP transporter VNUT mediates induction of Dectin-1-triggered Candida nociception. (2018)
  • Author(s): Maruyama K, Takayama Y, Sugisawa E, Yamanoi Y, Yokawa T, Kondo T, Ishibashi KI, Sahoo BR, Takemura N, Mori Y, Kanemaru H, Kumagai Y, Martino MM, Yoshioka Y, Nishijo H, Tanaka H, Sasaki A, Ohno N, Iwakura Y, Moriyama Y, Nomura M, Akira S, Tominaga M.
  • Journal Title: iScience Volume: 6 Pages: 306-318
  • DOI: 10.1016/j.isci.2018.08.007
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] IL-36a is involved in hapten-specific T-cell induction, but not local inflammation, during contact hypersensitivity. (2018)
  • Author(s): Numata Takafumi、Yoshizaki Takamichi、Yamaguchi Sachiko、Shimura Eri、Iwakura Yoichiro、Harada Kazutoshi、Sudo Katsuko、Tsuboi Ryoji、Nakae Susumu
  • Journal Title: Biochem Biophys Res Commun Volume: 506 Pages: 429-436
  • DOI: 10.1016/j.bbrc.2018.10.104
  • Peer Reviewed / Open Access
• [Journal Article] IL-6, IL-17 and Stat3 are required for auto-inflammatory syndrome development in mouse (2018)
  • Author(s): Oike T, Kanagawa H, Sato Y, Kobayashi T, Nakatsukasa H, Miyamoto K, Nakamura S, Kaneko Y, Kobayashi S, Harato K, Yoshimura A, Iwakura Y, Takeuchi T, Matsumoto M, Nakamura M, Niki Y, Miyamoto T.
  • Journal Title: Sci Rep Volume: - Pages: 15783-15783
  • DOI: 10.1038/s41598-018-34173-5
  • Peer Reviewed / Open Access
• [Journal Article] TLR-stimulated IRAKM activates caspase-8 inflammasome in microglia and promotes neuroinflammation. (2018)
  • Author(s): Zhang Cun-Jin、Jiang Meiling、Zhou Hao、Liu Weiwei、Wang Chenhui、Kang Zizhen、Han Bing、Zhang Quanri、Chen Xing、Xiao Jianxin、Fisher Amanda、Kaiser William J.、Murayama Masanori A.、Iwakura Yoichiro、Gao Ji、Carman Julie、Dongre Ashok、Dubyak George、Abbott Derek W.、Shi Fu-Dong、Ransohoff Richard M.、Li Xiaoxia
  • Journal Title: The Journal of clinical investigation Volume: 128 Pages: 5399-5412
  • DOI: 10.1172/jci121901
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Allergy inhibitory receptor-1 inhibits autoantibody production via upregulation of apoptotic debris clearance by macrophages (2018)
  • Author(s): Iizuka Akira、Segawa Seiji、Kondo Yuya、Kaneko Shunta、Yokosawa Masahiro、Furuyama Kotona、Miki Haruka、Tahara‐Hanaoka Satoko、Shibuya Akira、Tsuboi Hiroto、Goto Daisuke、Matsumoto Isao、Shibayama Shiro、Sumida Takayuki
  • Journal Title: Int J Rheum Dis Volume: 21 Pages: 2071-2078
  • DOI: 10.1111/1756-185x.13381
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Exploring the Gut Fungi-Lung Allergy Axis (2018)
  • Author(s): Shibuya Akira、Shibuya Kazuko
  • Journal Title: Cell Host Microbe Volume: 24 Pages: 755-757
  • DOI: 10.1016/j.chom.2018.11.012
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Elovl6 regulates mechanical damage-induced keratinocyte death and skin inflammation (2018)
  • Author(s): Nakamura Y, Matsuzaka T, Tahara-Hanaoka S, Shibuya K, Shimano H, Nakahashi-Oda C, Shibuya A.
  • Journal Title: Cell Death and Diseases Volume: 9(12) Pages: 1181-1181
  • DOI: 10.1038/s41419-018-1226-1
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Forebrain Ptf1a Is Required for Sexual Differentiation of the Brain (2018)
  • Author(s): T Fujiyama, S Miyashita, Y Tsuneoka, K Kanemaru, M Kakizaki, S Kanno, Y Ishikawa, M Yamashita, T Owa, M Nagaoka, Y Kawaguchi, Y Yanagawa, M A. Magnuson, A Shibuya, Y Nabeshima, M Yanagisawa, H Funato*, M Hoshino*
  • Journal Title: Cell Rep Volume: 24 Pages: 79-94
  • DOI: 10.1016/j.celrep.2018.06.010
  • NAID: 120006523922
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Glycoprotein nmb Is Exposed on the Surface of Dormant Breast Cancer Cells and Induces Stem Cell-like Properties. (2018)
  • Author(s): Chen Chen、Okita Yukari、Watanabe Yukihide、Abe Fumie、Fikry Muhammad Ali、Ichikawa Yumu、Suzuki Hiroyuki、Shibuya Akira、Kato Mitsuyasu
  • Journal Title: Cancer Res. Volume: 78 Pages: 6424-6435
  • DOI: 10.1158/0008-5472.can-18-0599
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Selective DNAM-1 expression on small peritoneal macrophages contributes to CD4+ T cell costimulation (2018)
  • Author(s): Takenaka Eri、Van Vo Anh、Yamashita-Kanemaru Yumi、Shibuya Akira、Shibuya Kazuko
  • Journal Title: Sci Rep Volume: 8 Pages: 15180-15180
  • DOI: 10.1038/s41598-018-33437-4
  • NAID: 120006542251
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Cutting Edge: Identification of Marginal Reticular Cells as Phagocytes of Apoptotic B Cells in Germinal Centers. (2018)
  • Author(s): Sato Kazuki、Honda Shin-ichiro、Shibuya Akira、Shibuya Kazuko
  • Journal Title: J Immunol Volume: 200 Pages: 3691-3696
  • DOI: 10.4049/jimmunol.1701293
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] TX99 Is a Neutralizing Monoclonal Antibody Against Mouse TIGIT (2018)
  • Author(s): Nakamura Yuho , Naito Keisuke , Yamashita-Kanemaru Yumi , Komori Daisuke , Hirochika Rei , Shibuya Akira , and Shibuya Kazuko
  • Journal Title: Monoclon Antib Immunodiagn Immunother Volume: 印刷中 Pages: 105-109
  • DOI: 10.1089/mab.2018.0001
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Serum selenoprotein P, but not selenium, predicts future hyperglycemia in a general Japanese population (2018)
  • Author(s): Oo SM, Misu H, Saito Y, Tanaka M, Kato S, Kita Y, Takayama H, Takeshita Y, Kanamori T, Nagano T, Nakagen M, Urabe T, Matsuyama N, Kaneko S, Takamura T.
  • Journal Title: Sci Rep Volume: 8 Pages: 16727-16727
  • DOI: 10.1038/s41598-018-35067-2
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Comparison of Human Selenoprotein P Determinants in Serum between Our Original Methods and Commercially Available Kits (2018)
  • Author(s): Saito Yoshiro、Misu Hirofumi、Takayama Hiroaki、Takashima Shin-ichiro、Usui Soichiro、Takamura Masayuki、Kaneko Shuichi、Takamura Toshinari、Noguchi Noriko
  • Journal Title: Biol. Pharm. Bull. Volume: 41 Issue: 5 Pages: 828-832
  • DOI: 10.1248/bpb.b18-00046
  • NAID: 130006730702
  • ISSN: 0918-6158, 1347-5215
  • Peer Reviewed / Open Access
• [Journal Article] Inhibin βE (INHBE) is a possible insulin resistance-associated hepatokine identified by comprehensive gene expression analysis in human liver biopsy samples (2018)
  • Author(s): M. Sugiyama, A. Kikuchi, H. Misu, H. Igawa, M. Ashihara, Y. Kushima, K. Honda, Y. Suzuki, Y. Kawabe, S. Kaneko and T. Takamura
  • Journal Title: PLOS ONE Volume: 13
  • DOI: 10.1371/journal.pone.0194798
  • Peer Reviewed / Open Access
• [Journal Article] Endogenous Selenoprotein P, a Liver-Derived Secretory Protein, Mediates Myocardial Ischemia/Reperfusion Injury in Mice (2018)
  • Author(s): Chikata A, Kato T, Usuda K, Fujita S, Maruyama M, Nagata Y, Sakagami S, Kanamori N, Yaegashi T, Saeki T, Kusayama T, Usui S, Furusho H, Kaneko S, Takamura M.
  • Journal Title: International Journal of Molecular Sciences Volume: 19 Pages: 878-878
  • DOI: 10.3390/ijms19030878
  • Peer Reviewed / Open Access
• [Journal Article] Light alcohol consumption has the potential to suppress hepatocellular injury and liver fibrosis in non-alcoholic fatty liver disease (2018)
  • Author(s): K Yamada, E Mizukoshi, T Seike, R Horii, M Kitahara, H Sunagozaka, K Arai, T Yamashita, M Honda, S Kaneko.
  • Journal Title: PLOS ONE Volume: 13
  • DOI: 10.1371/journal.pone.0191026
  • Peer Reviewed / Open Access
• [Journal Article] Sirt2 facilitates hepatic glucose uptake by deacetylating glucokinase regulatory protein. (2018)
  • Author(s): Watanabe Hitoshi、Inaba Yuka、Kimura Kumi、Matsumoto Michihiro、Kaneko Shuichi、Kasuga Masato、Inoue Hiroshi
  • Journal Title: Nature Communications Volume: 9 Pages: 30-30
  • DOI: 10.1038/s41467-017-02537-6
  • NAID: 40021854359
  • Peer Reviewed / Open Access
• [Journal Article] Asymmetric Integration of Single-Cell Transcriptomic Data using Latent Dirichlet Allocation and Procrustes Analysis (2018)
  • Author(s): Eto Mitsuhiro、Hirota Wataru、Seno Shigeto、Matsuda Hideo
  • Journal Title: IEEE International Conference on Bioinformatics and Biomedicin Volume: - Pages: 2129-2135
  • DOI: 10.1109/bibm.2018.8621115
  • Peer Reviewed
• [Journal Article] Regnase-1 controls colon epithelial regeneration via regulation of mTOR and purine metabolism (2018)
  • Author(s): Nagahama, Y. Shimoda, M. Mao, G. Singh, S. K. Kozakai, Y. Sun, X. Motooka, D. Nakamura, S. Tanaka, H. Satoh, T. Maeda, K. Akira, S.
  • Journal Title: Proceedings of the National Academy of Sciences Volume: 115 Pages: 11036-11041
  • DOI: 10.1073/pnas.1809575115
  • Peer Reviewed / Open Access
• [Journal Article] Infection with flaviviruses requires BCLXL for cell survival (2018)
  • Author(s): Suzuki T, Okamoto T, Katoh H, Sugiyama Y, Kusakabe S, Tokunaga M, Hirano J, Miyata Y, Fukuhara T, Ikawa M, Satoh T, Yoshio S, Suzuki R, Saijo M, Huang DCS, Kanto T, Akira S Matsuura Y
  • Journal Title: PLOS Pathogens Volume: 14
  • DOI: 10.1371/journal.ppat.1007299
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Electrophilic properties of itaconate and derivatives regulate the?IκBζ?ATF3 inflammatory axis (2018)
  • Author(s): Bambouskova M, Gorvel L, Lampropoulou V, Sergushichev A, Loginicheva E, Johnson K, Korenfeld D, Mathyer ME, Kim H, Huang LH, Duncan D, Bregman H, Keskin A, Santeford A, Apte RS, Sehgal R, Johnson B, Amarasinghe GK, Soares MP, Satoh T.
  • Journal Title: Nature Volume: 556 Pages: 501-504
  • DOI: 10.1038/s41586-018-0052-z
  • Peer Reviewed
• [Journal Article] BATF2 activates DUSP2 gene expression and upregulates NF-кB activity via phospho-STAT3 dephosphorylation. (2018)
  • Author(s): Kanemaru H, Yamane F, Tanaka H, Maeda K, Satoh T, Akira S.
  • Journal Title: International Immunology Volume: dxy023 Pages: 255-265
  • DOI: 10.1093/intimm/dxy023
  • Peer Reviewed / Open Access
• [Journal Article] Sulindac sulfone inhibits the mTORC1 pathway in colon cancer cells by directly targeting voltage-dependent anion channel 1 and 2. (2018)
  • Author(s): Aono Yuichi、Horinaka Mano、Iizumi Yosuke、Watanabe Motoki、Taniguchi Tomoyuki、Yasuda Shusuke、Sakai Toshiyuki
  • Journal Title: Biochem Biophys Res Commun. Volume: 505 Pages: 1203-1210
  • DOI: 10.1016/j.bbrc.2018.10.050
  • Peer Reviewed
• [Journal Article] Mevalonate pathway blockage enhances the efficacy of mTOR inhibitors with the activation of retinoblastoma protein in renal cell carcinoma (2018)
  • Author(s): Hagiwara Nobuhisa、Watanabe Motoki、Iizuka-Ohashi Mahiro、Yokota Isao、Toriyama Seijiro、Sukeno Mamiko、Tomosugi Mitsuhiro、Sowa Yoshihiro、Hongo Fumiya、Mikami Kazuya、Soh Jintetsu、Fujito Akira、Miyashita Hiroaki、Morioka Yukako、Miki Tsuneharu、Ukimura Osamu、Sakai Toshiyuki
  • Journal Title: Cancer Lett. Volume: 431 Pages: 182-189
  • DOI: 10.1016/j.canlet.2018.05.025
  • Peer Reviewed
• [Journal Article] Blockage of the mevalonate pathway overcomes the apoptotic resistance to MEK inhibitors with suppressing the activation of Akt in cancer cells (2018)
  • Author(s): Iizuka-Ohashi M1,2, Watanabe M1, Sukeno M1, Morita M1, Hoang NTH3, Kuchimaru T, Kizaka-Kondoh S, Sowa Y1 Sakaguchi K, Taguchi T, Sakai T.
  • Journal Title: Oncotarget Volume: 9 Pages: 19597-19612
  • DOI: 10.18632/oncotarget.24696
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Reinforce the antitumor activity of CD8+ T cells via glutamine restriction. (2018)
  • Author(s): Nabe Shogo、Yamada Takeshi、Suzuki Junpei、Toriyama Koji、Yasuoka Toshiaki、Kuwahara Makoto、Shiraishi Atsushi、Takenaka Katsuto、Yasukawa Masaki、Yamashita Masakatsu
  • Journal Title: Cancer Sci Volume: 109 Pages: 3737-3750
  • DOI: 10.1111/cas.13827
  • Peer Reviewed / Open Access
• [Journal Article] The tumor suppressor menin prevents effector CD8 T-cell dysfunction by targeting mTORC1-dependent metabolic activation (2018)
  • Author(s): Suzuki Junpei、Yamada Takeshi、Inoue Kazuki、Nabe Shogo、Kuwahara Makoto、Takemori Nobuaki、Takemori Ayako、Matsuda Seiji、Kanoh Makoto、Imai Yuuki、Yasukawa Masaki、Yamashita Masakatsu
  • Journal Title: Nature Communications Volume: 9 Pages: 1-12
  • DOI: 10.1038/s41467-018-05854-6
  • Peer Reviewed / Open Access
• [Journal Article] Three-step transcriptional priming that drives the commitment of multipotent progenitors toward B cells (2018)
  • Author(s): Miyai Tomohiro、Takano Junichiro、Endo Takaho A.、Kawakami Eiryo、Agata Yasutoshi、Motomura Yasutaka、Kubo Masato、Kashima Yukie、Suzuki Yutaka、Kawamoto Hiroshi、Ikawa Tomokatsu
  • Journal Title: Genes Dev Volume: 32 Pages: 112-126
  • DOI: 10.1101/gad.309575.117
  • Peer Reviewed
• [Journal Article] GITR cosignal in ILC2s controls allergic lung inflammation (2018)
  • Author(s): Nagashima H, Okuyama Y, Fujita T, Takeda T, Motomura Y, Moro K, Hidaka T, Omori K, Sakurai T, Machiyama T, Ndhlovu LC, Riccardi C, So T, Ishii N.
  • Journal Title: Journal of Allergy and Clinical Immunology Volume: -
  • DOI: 10.1016/j.jaci.2018.01.028
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Proteomics analysis identified peroxiredoxin 2 involved in early-phase left ventricular impairment in hamsters with cardiomyopathy (2018)
  • Author(s): Kuzuya K, Ichihara S, Suzuki Y, Inoue C, Ichihara G, Kurimoto S, Oikawa S.
  • Journal Title: Plos One Volume: 13
  • DOI: 10.1371/journal.pone.0192624
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] The DNA methylation profile of liver tumors in C3H mice and identification of differentially methylated regions involved in the regulation of tumorigenic genes (2018)
  • Author(s): Matsushita J, Okamura K, Nakabayashi K, Suzuki T, Horibe Y, Kawai T, Sakurai T, Yamashita S, Higami Y, Ichihara G, Hata K, Nohara K
  • Journal Title: BMC Cancer Volume: 18 Pages: 317-317
  • DOI: 10.1186/s12885-018-4221-0
  • Peer Reviewed / Open Access
• [Journal Article] Pulmonary hypofunction due to calcium carbonate nanomaterials exposure in occupational workers, cross-sectional study. (2018)
  • Author(s): Li Guoliang、Liang Lihong、Yang Jingchao、Zeng Lihai、Xie Zhiwei、Zhong Yizhou、Ruan Xiaolin、Dong Ming、Yang Zhanhong、Lai Guanchao、Huang Weixin、Yang Aichu、Chen Jiabing、Wu Banghua、Xu Huaming、Meng Dezhi、Hu Shijie、Xia Lihua、Yang Xingfen、Li Laiyu、Ichihara Sahoko、Ichihara Gaku、Huang Hanlin、Huang Zhenlie
  • Journal Title: Nanotoxicology Volume: 12 Pages: 571-585
  • DOI: 10.1080/17435390.2018.1465606
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Exposure to 1,2-Dichloropropane Upregulates the Expression of Activation-Induced Cytidine Deaminase (AID) in Human Cholangiocytes Co-Cultured With Macrophages (2018)
  • Author(s): Zong Cai、Kimura Yusuke、Kinoshita Kazuo、Takasu Shigetada、Zhang Xiao、Sakurai Toshihiro、Sekido Yoshitaka、Ichihara Sahoko、Endo Ginji、Ichihara Gaku
  • Journal Title: Toxicological Sciences Volume: 168 Pages: 137-148
  • DOI: 10.1093/toxsci/kfy280
  • Peer Reviewed
• [Journal Article] Occupational Exposure Limits for ethylidene norbornene, ethyleneimine, benomyl, and 2,3-epoxypropyl methacrylate, and classifications on carcinogenicity (2018)
  • Author(s): Committee for Recommendation of Occupational Exposure Limits, Japan Society for Occupational Health, Araki A, Azuma K, Endo G, Endo Y, Fukushima T, Hara K, Hori H, Horie S, Horiguchi H, Ichiba M, Ichihara G, Ikeda M, Ishitake T, Ito A, Ito Y, Iwasawa S, Kakumu T, Kamijima M, Karita K.
  • Journal Title: J Occup Health Volume: 60 Issue: 4 Pages: 333-335
  • DOI: 10.1539/joh.2018-0137-op 10.1539/joh.2018-0137-OP
  • NAID: 130007403028
  • ISSN: 1341-9145, 1348-9585
  • Peer Reviewed / Open Access
• [Journal Article] Carcinogenicity of isobutyl nitrite, β-picoline, and some acrylates (2018)
  • Author(s): Kromhout H, Friesen M, Marques MM, Sergi CM, Abdallah M, Benke G, Cesta M, Germolec D, Houck K, Ichihara G, Jameson CW, Kanno J, Pogribny I, Svendsen C, Benbrahim-Tallaa L, Guyton KZ, Grosse Y, El Ghissassi F, Bouvard V, Hall A.
  • Journal Title: The Lancet Oncology Volume: 19 Pages: 1020-1022
  • DOI: 10.1016/s1470-2045(18)30491-1
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Familial episodic limb pain in kindreds with novel Nav1.9 mutations (2018)
  • Author(s): Kabata R, Okuda H, Noguchi A, Kondo D, Fujiwara M, Hata K, Kato Y, Ishikawa K, Tanaka M, Sekine Y, Hishikawa N, Mizukami T, Ito J, Akasaka M, Sakurai K, Yoshida T, Minoura H, Hayashi T, Inoshita K, Matsuyama M, Kinjo N, Cao Y, Inoue S, Kobayashi H, Harada KH, Youssefian S, Takahashi T, Koizumi A.
  • Journal Title: PLOS ONE Volume: 13
  • DOI: 10.1371/journal.pone.0208516
  • Peer Reviewed / Open Access
• [Journal Article] Rare variants in RNF213, a susceptibility gene for moyamoya disease, are found in patients with pulmonary hypertension and aggravate hypoxia-induced pulmonary hypertension in mice (2018)
  • Author(s): Kobayashi Hatasu、Kabata Risako、Kinoshita Hideyuki、Morimoto Takaaki、Ono Koh、Takeda Midori、Choi Jungmi、Okuda Hiroko、Liu Wanyang、Harada Kouji H、Kimura Takeshi、Youssefian Shohab、Koizumi Akio
  • Journal Title: Pulmonary Circulation Volume: - Pages: 204589401877815-204589401877815
  • DOI: 10.1177/2045894018778155
  • Peer Reviewed / Open Access
• [Journal Article] Dysregulation of RNF213 promotes cerebral hypoperfusion (2018)
  • Author(s): Morimoto T, Enmi J, Hattori Y, Iguchi S, Saito S, Harada K, Okuda H, Mineharu Y, Takagi Y, Youssefian S, Iida H, Miyamoto S, Ihara M, Kobayashi H, Koizumi A.
  • Journal Title: Sci Rep. Volume: 8 Pages: 3607-3607
  • DOI: 10.1038/s41598-018-22064-8
  • NAID: 120006535057
  • Peer Reviewed / Open Access
• [Journal Article] β-cell-specific overexpression of adiponectin receptor 1 does not improve diabetes mellitus in Akita mice (2018)
  • Author(s): Choi J, Kobayashi H, Okuda H, Harada KH, Takeda M, Fujimoto H, Yamane S, Tanaka D, Youssefian S, Inagaki N, Koizumi A.
  • Journal Title: PLOS ONE Volume: 13 (1)
  • DOI: 10.1371/journal.pone.0190863
  • NAID: 120006459971
  • Peer Reviewed / Open Access
• [Journal Article] Protein Residue Networks from Energetic and Geometric Data: Are They Identical? (2018)
  • Author(s): Vladimir Sladek, Hiroaki Tokiwa, Hitoshi Shimano, Yasuteru Shigeta
  • Journal Title: J Chem Theory Comput. Volume: 14(12) Pages: 6623-6631
  • DOI: 10.1021/acs.jctc.8b00733
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Network meta-analysis of the relative efficacy of bariatric surgeries for diabetes remission (2018)
  • Author(s): Kodama S.、Fujihara K.、Horikawa C.、Harada M.、Ishiguro H.、Kaneko M.、Furukawa K.、Matsubayashi Y.、Matsunaga S.、Shimano H.、Tanaka S.、Kato K.、Sone H.
  • Journal Title: Obesity Reviews Volume: 19 Pages: 1621-1629
  • DOI: 10.1111/obr.12751
  • Peer Reviewed
• [Journal Article] Relationship between intake of fruit separately from vegetables and triglycerides - A meta-analysis (2018)
  • Author(s): Kodama S, Horikawa C, Fujihara K, Ishii D, Hatta M, Takeda Y, Kitazawa M, Matsubayashi Y, Shimano H, Kato K, Tanaka S, Sone H
  • Journal Title: Clinical Nutrition ESPEN Volume: 27 Pages: 53-58
  • DOI: 10.1016/j.clnesp.2018.07.001
  • Peer Reviewed / Open Access
• [Journal Article] Proliferator-Activated Receptor α (PPARα) Agonist Pemafibrate Protects against Diet-Induced Obesity in Mice. (2018)
  • Author(s): Araki Masaya、Nakagawa Yoshimi、Oishi Asayo、Han Song-iee、Wang Yunong、Kumagai Kae、Ohno Hiroshi、Mizunoe Yuhei、Iwasaki Hitoshi、Sekiya Motohiro、Matsuzaka Takashi、Shimano Hitoshi
  • Journal Title: International journal of molecular sciences Volume: 19 Pages: 2148-2148
  • DOI: 10.3390/ijms19072148
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Brg1 regulates pro-lipogenic transcription by modulating SREBP activity in hepatocytes. (2018)
  • Author(s): Li Nan、Li Min、Hong Wenxuan、Shao Jing、Xu Huihui、Shimano Hitoshi、Lu Jun、Xu Yong
  • Journal Title: Biochim Biophys Acta Mol Basis Dis. Volume: 1864 Pages: 2881-2889
  • DOI: 10.1016/j.bbadis.2018.05.022
  • Peer Reviewed
• [Journal Article] Malondialdehyde-modified LDL-related variables are associated with diabetic kidney disease in type 2 diabetes (2018)
  • Author(s): Furukawa Shoko、Suzuki Hiroaki、Fujihara Kazuya、Kobayashi Kazuto、Iwasaki Hitoshi、Sugano Yoko、Yatoh Shigeru、Sekiya Motohiro、Yahagi Naoya、Shimano Hitoshi
  • Journal Title: Diabetes Research and Clinical Practice Volume: 141 Pages: 237-243
  • DOI: 10.1016/j.diabres.2018.05.019
  • Peer Reviewed
• [Journal Article] CREBH Regulates Systemic Glucose and Lipid Metabolism. (2018)
  • Author(s): Nakagawa Yoshimi、Shimano Hitoshi
  • Journal Title: Int J Mol Sci. Volume: 19 Pages: 1396-1396
  • DOI: 10.3390/ijms19051396
  • NAID: 120006501396
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Evaluation of safety for hepatectomy in a novel mouse model with nonalcoholic-steatohepatitis (2018)
  • Author(s): Ozawa Yusuke、Tamura Takafumi、Owada Yohei、Shimizu Yoshio、Kemmochi Akira、Hisakura Katsuji、Matsuzaka Takashi、Shimano Hitoshi、Isoda Hiroko、Ohkohchi Nobuhiro
  • Journal Title: World Journal of Gastroenterology Volume: 24 Pages: 1622-1631
  • DOI: 10.3748/wjg.v24.i15.1622
  • Peer Reviewed
• [Journal Article] Transgenic mice overexpressing SREBP-1a in male ob/ob mice exhibit lipodystrophy and exacerbate insulin resistance (2018)
  • Author(s): Ohno H, Matsuzaka T, Tang N, Sharma R, Motomura K, Shimura T, Satoh A, Han SI, Takeuchi Y, Aita Y, Iwasaki H, Yatoh S, Suzuki H, Sekiya M, Nakagawa Y, Sone H, Yahagi N, Yamada N, Higami Y, Shimano H.
  • Journal Title: Endocrinology Volume: 159(6) Pages: 2308-2323
  • DOI: 10.1210/en.2017-03179
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Molecular association model of PPARα and its new specific and efficient ligand, pemafibrate: Structural basis for SPPARMα. (2018)
  • Author(s): Yamamoto Yuta、Takei Kenta、Arulmozhiraja Sundaram、Sladek Vladimir、Matsuo Naoya、Han Song-iee、Matsuzaka Takashi、Sekiya Motohiro、Tokiwa Takaki、Shoji Mitsuo、Shigeta Yasuteru、Nakagawa Yoshimi、Tokiwa Hiroaki、Shimano Hitoshi
  • Journal Title: Biochem Biophys Res Commun Volume: 499 Pages: 239-245
  • DOI: 10.1016/j.bbrc.2018.03.135
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Saturated fatty acids undergo intracellular crystallization and activate the NLRP3 inflammasome in macrophages. (2018)
  • Author(s): Karasawa Tadayoshi、Kawashima Akira、Usui-Kawanishi Fumitake、Watanabe Sachiko、Kimura Hiroaki、Kamata Ryo、Shirasuna Koumei、Koyama Yutaro、Sato-Tomita Ayana、Matsuzaka Takashi、Tomoda Hiroshi、Park Sam-Yong、Shibayama Naoya、Shimano Hitoshi、Kasahara Tadashi、Takahashi Masafumi
  • Journal Title: Arterioscler Thromb Vasc Biol. Volume: 38 Pages: 744-756
  • DOI: 10.1161/atvbaha.117.310581
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Epigenetic modulation of fibroblast growth factor 21 in the perinatal mouse liver is associated with the attenuation of diet-induced obesity in adulthood (2018)
  • Author(s): X Yuan, K Tsujimoto, K Hashimoto, K Kawahori, N Hanzawa, M Hamaguchi, T Seki, M Nawa, T Ehara, Y Kitamura, I Hatada, M Konishi, N Itoh, Y Nakagawa, H Shimano, T Takai-Igarashi, Y Kamei, Y Ogawa.
  • Journal Title: Nat. Commun. Volume: 9 Pages: 636-636
  • DOI: 10.1038/s41467-018-03038-w
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Age-dependent changes in dynamic standing-balance ability evaluated quantitatively using a stabilometer (2018)
  • Author(s): Suzuki Yasuhiro、Yatoh Shigeru、Suzuki Hiroaki、Tanabe Yuuki、Shimizu Yukiyo、Hada Yasushi、Shimano Hitoshi
  • Journal Title: J Phys Ther Sci Volume: 30 Issue: 1 Pages: 86-91
  • DOI: 10.1589/jpts.30.86
  • NAID: 130006321186
  • ISSN: 0915-5287, 2187-5626
  • Peer Reviewed
• [Journal Article] A candidate functional SNP rs7074440 in TCF7L2 alters gene expression through C-FOS in hepatocytes (2018)
  • Author(s): Piao X, Yahagi N, Takeuchi Y, Aita Y, Murayama Y, Sawada Y, Shikama A, Masuda Y, Nishi-Tatsumi M, Kubota M, Izumida Y, Sekiya M, Matsuzaka T, Nakagawa Y, Sugano Y, Iwasaki H, Kobayashi K, Yatoh S, Suzuki H, Yagyu H, Kawakami Y, Shimano H.
  • Journal Title: FEBS Letters Volume: 592(3) Pages: 422-433
  • DOI: 10.1002/1873-3468.12975
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] A Rare Coexistence of Pheochromocytoma and Parkinson's Disease With Diagnostic Challenges (2018)
  • Author(s): Matsumura-Matsuda Erika、Sekiya Motohiro、Omoto-Inuzuka Miyoko、Santo Kana、Shikama Akito、Kuba Motoko、Sugano Yoko、Iwasaki Hitoshi、Yatoh Shigeru、Sato Taiki、Hara Hisato、Takekoshi Kazuhiro、Suzuki Hiroaki、Shimano Hitoshi
  • Journal Title: Intern. Med. Volume: 57 Issue: 7 Pages: 979-985
  • DOI: 10.2169/internalmedicine.9242-17
  • NAID: 130006602591
  • ISSN: 0918-2918, 1349-7235
  • Peer Reviewed
• [Journal Article] Relationships among cardiorespiratory fitness, muscular fitness, and cardiometabolic risk factors in Japanese adolescents: Niigata screening for and preventing the development of non-communicable disease study-Agano (NICE EVIDENCE Study-Agano) 2 (2018)
  • Author(s): Morikawa SY, Fujihara K, Hatta M, Osawa T, Ishizawa M, Yamamoto M, Furukawa K, Ishiguro H, Matsunaga S, Ogawa Y, Shimano H, Sone H.
  • Journal Title: Pediatric Diabetes Volume: 印刷中 Pages: 593-602
  • DOI: 10.1111/pedi.12623
  • Peer Reviewed / Open Access
• [Journal Article] Monopoiesis in humans and mice (2018)
  • Author(s): Kawamura Shunsuke、Ohteki Toshiaki
  • Journal Title: International Immunology Volume: 30 Pages: 503-509
  • DOI: 10.1093/intimm/dxy063
  • Peer Reviewed
• [Journal Article] IFN-γ-dependent epigenetic regulation instructs colitogenic monocyte/macrophage lineage differentiation in vivo (2018)
  • Author(s): Nakanishi Y, Sato T, Takahashi K, Ohteki T.
  • Journal Title: Mucosal Immunology Volume: - Pages: 871-880
  • DOI: 10.1038/mi.2017.104
  • Peer Reviewed
• [Journal Article] Macrophages in inflammation, repair and regeneration. (2018)
  • Author(s): Oishi Y, Manabe I
  • Journal Title: International Immunology Volume: 30 Pages: 511-528
  • DOI: 10.1093/intimm/dxy054
  • Peer Reviewed / Open Access
• [Journal Article] Does the prenatal bisphenol A exposure alter DNA methylation levels in the mouse hippocampus?: An analysis using a high-sensitivity methylome technique (2018)
  • Author(s): Aiba Toshiki、Saito Toshiyuki、Hayashi Akiko、Sato Shinji、Yunokawa Harunobu、Maruyama Toru、Fujibuchi Wataru、Ohsako Seiichiroh
  • Journal Title: Genes and Environment Volume: 40 Pages: 12-12
  • DOI: 10.1186/s41021-018-0099-y
  • Peer Reviewed
• [Journal Article] Detection of dioxin-induced demethylation of mouse Cyp1a1 gene promoter by a new labeling method for short DNA fragments possessing 5'-methylcytosine at the end (2018)
  • Author(s): Kurita Hisaka、Aiba Toshiki、Saito Toshiyuki、Ohsako Seiichiroh
  • Journal Title: Genes and Environment Volume: 40 Pages: 1-1
  • DOI: 10.1186/s41021-017-0089-5
  • Peer Reviewed / Open Access
• [Journal Article] Lung fibroblasts express a miR-19a-19b-20a sub-cluster to suppress TGF-β-associated fibroblast activation in murine pulmonary fibrosis (2018)
  • Author(s): Souma Kunihiko、Shichino Shigeyuki、Hashimoto Shinichi、Ueha Satoshi、Tsukui Tatsuya、Nakajima Takuya、Suzuki Hiroshi I.、Shand Francis H. W.、Inagaki Yutaka、Nagase Takahide、Matsushima Kouji
  • Journal Title: Scientific Reports Volume: 8 Pages: 1-14
  • DOI: 10.1038/s41598-018-34839-0
  • Peer Reviewed / Open Access
• [Journal Article] STAM-binding protein regulates melanoma metastasis through SLUG stabilization (2018)
  • Author(s): Iwakami Y, Yokoyama S, Watanabe K, Hayakawa Y.
  • Journal Title: Biochemical and Biophysical Research Communications Volume: 507 Pages: 484-488
  • DOI: 10.1016/j.bbrc.2018.11.068
  • Peer Reviewed / Open Access
• [Journal Article] Lung-resident natural killer cells control pulmonary tumor growth in mice (2018)
  • Author(s): Yamamoto Yutaka、Miyazato Kiho、Takahashi Kei、Yoshimura Naoki、Tahara Hideaki、Hayakawa Yoshihiro
  • Journal Title: Cancer Sci. Volume: 109 Pages: 2670-2676
  • DOI: 10.1111/cas.13703
  • Peer Reviewed / Open Access
• [Journal Article] A Gata3 3' Distal Otic Vesicle Enhancer Directs Inner Ear-Specific Gata3 Expression. (2018)
  • Author(s): Moriguchi Takashi、Hoshino Tomofumi、Rao Arvind、Yu Lei、Takai Jun、Uemura Satoshi、Ise Kazue、Nakamura Yasuhiro、Lim Kim-Chew、Shimizu Ritsuko、Yamamoto Masayuki、Engel James Douglas
  • Journal Title: Mol Cell Biol. Volume: 38 Pages: 21-21
  • DOI: 10.1128/mcb.00302-18
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Satellite RNA Increases DNA Damage and Accelerates Tumor Formation in Mouse Models of Pancreatic Cancer (2018)
  • Author(s): Kishikawa Takahiro、Otsuka Motoyuki、Suzuki Tatsunori、Seimiya Takahiro、Sekiba Kazuma、Ishibashi Rei、Tanaka Eri、Ohno Motoko、Yamagami Mari、Koike Kazuhiko
  • Journal Title: Molecular Cancer Research Volume: 16 Pages: 1255-1262
  • DOI: 10.1158/1541-7786.mcr-18-0139
  • Peer Reviewed / Open Access
• [Journal Article] MicroRNA-7: a potent suppressor of the malignant potential of hepatocellular carcinoma (2018)
  • Author(s): Otsuka Motoyuki、Tanaka Eri、Sekiba Kazuma、Seimiya Takahiro、Yamagami Mari、Koike Kazuhiko
  • Journal Title: Non-coding RNA Investigation Volume: 2 Pages: 30-30
  • DOI: 10.21037/ncri.2018.05.04
  • Peer Reviewed
• [Journal Article] Hepatitis B virus pathogenesis: Fresh insights into hepatitis B virus RNA (2018)
  • Author(s): Sekiba Kazuma、Otsuka Motoyuki、Ohno Motoko、Yamagami Mari、Kishikawa Takahiro、Suzuki Tatsunori、Ishibashi Rei、Seimiya Takahiro、Tanaka Eri、Koike Kazuhiko
  • Journal Title: World Journal of Gastroenterology Volume: 24 Pages: 2261-2268
  • DOI: 10.3748/wjg.v24.i21.2261
  • Peer Reviewed / Open Access
• [Journal Article] DHX9 regulates production of hepatitis B virus-derived circular RNA and viral protein levels (2018)
  • Author(s): Sekiba Kazuma、Otsuka Motoyuki、Ohno Motoko、Kishikawa Takahiro、Yamagami Mari、Suzuki Tatsunori、Ishibashi Rei、Seimiya Takahiro、Tanaka Eri、Koike Kazuhiko
  • Journal Title: Oncotarget Volume: 9 Pages: 20953-20964
  • DOI: 10.18632/oncotarget.25104
  • Peer Reviewed / Open Access
• [Journal Article] β-glucans in food modify colonic microflora by inducing antimicrobial protein, calprotectin, in a Dectin-1-induced-IL-17F-dependent manner. (2018)
  • Author(s): Ishimoto, Y., Ishibashi, K. I., Yamanaka, D., Adachi, Y., Kanzaki, K., Iwakura, Y., and Ohno, N.
  • Journal Title: Mucosal Immunol Volume: 107 Pages: 2269-2278
  • DOI: 10.1038/mi.2017.86
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Suppression of IL-17F, but not of IL-17A, provides protection against colitis by inducing T_reg cells through modification of the intestinal microbiota. (2018)
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  • Journal Title: Nature immunology Volume: 19 Pages: 755-765
  • DOI: 10.1038/s41590-018-0134-y
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Effects of high fructose intake on liver injury progression in high fat diet induced fatty liver disease in ovariectomized female mice (2018)
  • Author(s): Ohashi Tomoko、Kato Masaki、Yamasaki Akihiro、Kuwano Akifumi、Suzuki Hideo、Kohjima Motoyuki、Ogawa Yoshihiro
  • Journal Title: Food Chem. Toxicol. Volume: 118 Pages: 190-197
  • DOI: 10.1016/j.fct.2018.05.006
  • Peer Reviewed
• [Journal Article] Obeticholic acid protects against hepatocyte death and liver fibrosis in a murine model of nonalcoholic steatohepatitis (2018)
  • Author(s): T. Goto, M. Itoh, T. Suganami, S. Kanai, I. Shirakawa, T. Sakai, M. Asakawa,T. Yoneyama, T. Kai, Y. Ogawa.
  • Journal Title: Sci Rep. Volume: 8 Pages: 8157-8157
  • DOI: 10.1038/s41598-018-26383-8
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Efficient identification of compounds suppressing protein precipitation via solvent screening using serial deletion mutants of the target protein (2018)
  • Author(s): Yunoki Kaori、Yoshinaga Sosuke、Takeda Mitsuhiro、Nagano Ryohei、Tsuchiya Yusuke、Sonoda Akihiro、Tsuji Tatsuichiro、Hirakane Makoto、Toda Etsuko、Terashima Yuya、Matsushima Kouji、Terasawa Hiroaki
  • Journal Title: Genes to Cells Volume: 23 Pages: 70-79
  • DOI: 10.1111/gtc.12554
  • Peer Reviewed
• [Journal Article] Single blood transfusion induces the production of donor-specific alloantibodies and regulatory T-cells mainly in the spleen. (2018)
  • Author(s): Ueta H, Kitazawa Y, Sawanobori Y, Ueno T, Ueha S, Matsushima K, Matsuno K.
  • Journal Title: International Immunology Volume: 30 Pages: 53-67
  • DOI: 10.1093/intimm/dxx078
  • Peer Reviewed / Open Access
• [Journal Article] Increased diversity with reduced “diversity evenness” of tumor infiltrating T-cells for the successful cancer immunotherapy. (2018)
  • Author(s): Hosoi A, Takeda K, Nagaoka K, Iino T, Matsushita H, Ueha S, Aoki S, Matsushima K, Kubo M, Morikawa T, Kitaura K, Suzuki R, Kakimi K.
  • Journal Title: SCIENITIFIC REPORTS. Volume: 8 Pages: 1058-1058
  • DOI: 10.1038/s41598-018-19548-y
  • Peer Reviewed / Open Access
• [Journal Article] NK Cells Control Tumor-Promoting Function of Neutrophils in Mice. (2018)
  • Author(s): Ogura K, Sato-Matsushita M, Yamamoto S, Hori T, Sasahara M, Iwakura Y, Saiki I, Tahara H, Hayakawa Y
  • Journal Title: Cancer immunology research Volume: 印刷中 Pages: 348-357
  • DOI: 10.1158/2326-6066.cir-17-0204
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  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Single blood transfusion induces the production of donor-specific alloantibodies and regulatory T cells mainly in the spleen. (2018)
  • Author(s): Ueta H, Kitazawa Y, Sawanobori Y, Ueno T, Ueha S, Matsushima K, Matsuno K.
  • Journal Title: Int Immunol Volume: 8 Pages: 53-67
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• [Journal Article] Dysregulation of RNF213 promotes cerebral hypoperfusion. (2018)
  • Author(s): Morimoto T, Enmi JI, Hattori Y, Iguchi S, Saito S, Harada KH, Okuda H, Mineharu Y, Takagi Y, Youssefian S, Iida H, Miyamoto S, Ihara M, Kobayashi H, Koizumi A.
  • Journal Title: Sci Rep Volume: 26 Pages: 3607-3607
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• [Journal Article] Correction to Synthesis of Potent and Selective Inhibitors of Aldo-Keto Reductase 1B10 and Their Efficacy against Proliferation, Metastasis, and Cisplatin Resistance of Lung Cancer Cells. (2018)
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  • Journal Title: J Med Chem Volume: 8 Pages: 1380-1380
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• [Journal Article] Expression of Xenobiotic Biomarkers CYP1 Family in Preputial Tissue of Patients with Hypospadias and Phimosis and Its Association with DNA Methylation Level of SRD5A2 Minimal Promoter. (2018)
  • Author(s): Ohsako S, Aiba T, Miyado M, Fukami M, Ogata T, Hayashi Y, Mizuno K, Kojima Y.
  • Journal Title: Arch Environ Contam Toxicol Volume: 74(2) Pages: 240-247
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• [Journal Article] Efficient identification of compounds suppressing protein precipitation via solvent screening using serial deletion mutants of the target protein. (2018)
  • Author(s): Yunoki K, Yoshinaga S, Takeda M, Nagano R, Tsuchiya Y, Sonoda A, Tsuji T, Hirakane M, Toda E, Terashima Y, Matsushima K, Terasawa H.
  • Journal Title: Genes Cells Volume: 23(2) Pages: 70-79
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• [Journal Article] NK Cells Control Tumor-Promoting Function of Neutrophils in Mice. (2018)
  • Author(s): Ogura K, Sato-Matsushita M, Yamamoto S, Hori T, Sasahara M, Iwakura Y, Saiki I, Tahara H, Hayakawa Y.
  • Journal Title: Cancer Immunol Res Volume: 23
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• [Journal Article] Increased diversity with reduced "diversity evenness" of tumor infiltrating T-cells for the successful cancer immunotherapy. (2018)
  • Author(s): Hosoi A, Takeda K, Nagaoka K, Iino T, Matsushita H, Ueha S, Aoki S, Matsushima K, Kubo M, Morikawa T, Kitaura K, Suzuki R, Kakimi K.
  • Journal Title: Sci Rep Volume: 18 Pages: 1058-1058
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• [Journal Article] The Dark Side of IFN-γ: Its Role in Promoting Cancer Immunoevasion (2017)
  • Author(s): Mojic M, Takeda K, Hayakawa Y.
  • Journal Title: Int J Mol Sci Volume: 28 Pages: 1-13
  • DOI: 10.3390/ijms19010089
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• [Journal Article] Long-Lasting Graft-Derived Donor T Cells Contribute to the Pathogenesis of Chronic Graft-versus-Host Disease in Mice. (2017)
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• [Journal Article] ASK1 facilitates tumor metastasis through phosphorylation of an ADP receptor P2Y(12) in platelets. (2017)
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  • Journal Title: Cell Death Differ Volume: 24(12) Pages: 2066-2076
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• [Journal Article] The CD45(+) fraction in murine adipose tissue derived stromal cells harbors immune-inhibitory inflammatory cells. (2017)
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  • Journal Title: Eur J Immunol Volume: 47(12) Pages: 2163-2174
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• [Journal Article] Effect of sodium-glucose cotransporter 2 (SGLT2) inhibition on weight loss is partly mediated by liver-brain-adipose neurocircuitry. (2017)
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  • Journal Title: Biochem Biophys Res Commun Volume: 4 Pages: 40-45
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• [Journal Article] Ribosomal protein S3 regulates XIAP expression independently of the NF-ホコB pathway in breast cancer cells. (2017)
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  • Journal Title: Oncol Rep Volume: 38(5) Pages: 3205-3210
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• [Journal Article] Report of the International Stem Cell Banking Initiative Workshop Activity: Current Hurdles and Progress in Seed-Stock Banking of Human Pluripotent Stem Cells. (2017)
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• [Journal Article] Comprehensive single-cell transcriptome analysis reveals heterogeneity in endometrioid adenocarcinoma tissues. (2017)
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• [Journal Article] Gene expression profiling of hepatocarcinogenesis in a mouse model of chronic hepatitis B. (2017)
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• [Journal Article] Combination of anti-CD4 antibody treatment and donor lymphocyte infusion ameliorates graft-versus-host disease while preserving graft-versus-tumor effects in murine allogeneic hematopoietic stem cell transplantation. (2017)
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• [Journal Article] Long non-coding RNA HOTAIR promotes cell migration by upregulating insulin growth factor-binding protein 2 in renal cell carcinoma. (2017)
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• [Journal Article] Proteasome Inhibitor-Loaded Micelles Enhance Antitumor Activity Through Macrophage Reprogramming by NF-ホコB Inhibition. (2017)
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• [Journal Article] Optimized retroviral transduction of mouse T cells for in vivo assessment of gene function. (2017)
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• [Journal Article] RNF213 p.R4810K Variant and Intracranial Arterial Stenosis or Occlusion in Relatives of Patients with Moyamoya Disease. (2017)
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• [Journal Article] Occupational exposure limits for ethylene glycol monobutyl ether, isoprene, isopropyl acetate and propyleneimine, and classifications on carcinogenicity, occupational sensitizer and reproductive toxicant. (2017)
  • Author(s): Committee for Recommendation of Occupational Exposure Limits, Japan Society for Occupational Health., Azuma K, Endo G, Endo Y, Fukushima T, Hara K, Hori H, Horie S, Horiguchi H, Ichiba M, Ichihara G, Ikeda M, Ishitake T, Ito A, Ito Y, Iwasawa S, Kamijima M, Karita K, Katoh T, Kawai T, Kawamoto T, Kishi R, et al.
  • Journal Title: J Occup Health Volume: 27 Pages: 364-366
  • Peer Reviewed
• [Journal Article] Elovl6 Deficiency Improves Glycemic Control in Diabetic db/db Mice by Expanding ホイ-Cell Mass and Increasing Insulin Secretory Capacity. (2017)
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  • Journal Title: Diabetes Volume: 66(7) Pages: 1833-1846
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• [Journal Article] CoptidisツRhizoma induces intrinsic apoptosis through BAX and BAK activation in human melanoma. (2017)
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• [Journal Article] Microarray analyses of otospheres derived from the cochlea in the inner ear identify putative transcription factors that regulate the characteristics of otospheres. (2017)
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  • Journal Title: PLoS One Volume: 12(6)
  • Peer Reviewed / Open Access
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