• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Preventive medicine through inflammation cellular sociology

Administrative Group

Project AreaPreventive medicine through inflammation cellular sociology
Project/Area Number 17H06391
Research Category

Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

Allocation TypeSingle-year Grants
Review Section Complex systems
Research InstitutionTokyo University of Science (2018-2021)
The University of Tokyo (2017)

Principal Investigator

Matsushima Kouji  東京理科大学, 研究推進機構生命医科学研究所, 教授 (50222427)

Co-Investigator(Kenkyū-buntansha) 橋本 真一  和歌山県立医科大学, 先端医学研究所, 教授 (00313099)
藤渕 航  京都大学, iPS細胞研究所, 教授 (60273512)
Project Period (FY) 2017-06-30 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥196,560,000 (Direct Cost: ¥151,200,000、Indirect Cost: ¥45,360,000)
Fiscal Year 2021: ¥33,150,000 (Direct Cost: ¥25,500,000、Indirect Cost: ¥7,650,000)
Fiscal Year 2020: ¥33,150,000 (Direct Cost: ¥25,500,000、Indirect Cost: ¥7,650,000)
Fiscal Year 2019: ¥33,150,000 (Direct Cost: ¥25,500,000、Indirect Cost: ¥7,650,000)
Fiscal Year 2018: ¥33,150,000 (Direct Cost: ¥25,500,000、Indirect Cost: ¥7,650,000)
Fiscal Year 2017: ¥63,960,000 (Direct Cost: ¥49,200,000、Indirect Cost: ¥14,760,000)
Keywords免疫 / 遺伝子 / 情報工学 / モデル化 / 病理学
Outline of Final Research Achievements

The Center for the analysis of Cellular Society of Inflammation, which supports scRNA-seq, various omics analyses, and information analysis, was set up under the General Affairs Group to support each planned and publicly research project. By using the standardized and optimized cell preparation technology of the project leaders and the highly sensitive and accurate scRNA-seq technology developed originally by the project leaders as the common basic technology for the project, a disease scRNA-seq database was constructed to enable cross-sectional data comparison across diseases and organs. We have also established a novel information analysis technology for biological interpretation of these data. Various target cells and molecules that could lead to the prevention and treatment of individual diseases have been obtained, and are expected to be applied to clinical development and disease prevention and treatment in the future.

Academic Significance and Societal Importance of the Research Achievements

肺、肝臓、腎臓、膵臓、腸管、皮膚などの疾患モデル、臨床検体について、サンプル調製からデータ解析までの工程を標準化したscRNA-seqデータを横断的に集積した炎症細胞社会データベースは、今後の疾患研究と創薬、そして予防戦略の構築に大きく貢献すると期待している。また、肺線維症における、病的C1q+ マクロファージやアミノ酸トランスポーター関連分子とその制御による線維化予防、2型糖尿病の未病状態特異的マーカーの同定、肝線維化診断マーカーの同定、慢性腎障害の予防剤、老化細胞除去剤、脳障害に対する保護剤などが見いだされており、今後の臨床開発への進展、疾患予防・治療への応用が期待される。

Report

(6 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Annual Research Report
  • 2019 Annual Research Report
  • 2018 Annual Research Report
  • 2017 Annual Research Report
  • Research Products

    (272 results)

All 2022 2021 2020 2019 2018 2017 Other

All Journal Article (264 results) (of which Int'l Joint Research: 96 results,  Peer Reviewed: 264 results,  Open Access: 219 results) Book (4 results) Remarks (3 results) Funded Workshop (1 results)

  • [Journal Article] Profibrotic properties of C1q+ interstitial macrophages in silica-induced pulmonary fibrosis in mice.2022

    • Author(s)
      Ogawa T, Shichino S, Ueha S, Bando K, Matsushima K.
    • Journal Title

      Biochem Biophys Res Commun.

      Volume: 599 Pages: 113-119

    • DOI

      10.1016/j.bbrc.2022.02.037

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Complement protein C1q activates lung fibroblasts and exacerbates silica-induced pulmonary fibrosis in mice.2022

    • Author(s)
      Ogawa T, Shichino S, Ueha S, Ogawa S, Matsushima K.
    • Journal Title

      Biochem Biophys Res Commun.

      Volume: 603 Pages: 88-93

    • DOI

      10.1016/j.bbrc.2022.02.090

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Revealing Clonal Responses of Tumor-Reactive T-Cells Through T Cell Receptor Repertoire Analysis.2022

    • Author(s)
      Aoki H, Shichino S, Matsushima K, Ueha S.
    • Journal Title

      Front Immunol.

      Volume: 13 Pages: 807696-807696

    • DOI

      10.3389/fimmu.2022.807696

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Intestinal Bacterial Translocation Contributes to Diabetic Kidney Disease.2022

    • Author(s)
      Linh HT, Iwata Y, Senda Y, Sakai-Takemori Y, Nakade Y, Oshima M, Nakagawa-Yoneda S, Ogura H, Sato K, Minami T, Kitajima S, Toyama T, Yamamura Y, Miyagawa T, Hara A, Shimizu M, Furuichi K, Sakai N, Yamada H, Asanuma K, Matsushima K, Wada T.
    • Journal Title

      J Am Soc Nephrol.

      Volume: - Issue: 6 Pages: 1105-1119

    • DOI

      10.1681/asn.2021060843

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Rare toxin A-negative and toxin B-positive strain of Clostridioides difficile from Japan lacking a complete tcdA gene.2022

    • Author(s)
      Takemori-Sakai Y, Satou K, Senda Y, Nakamura Y, Otani H, Maekawa A, Oe H, Oshima M, Yoneda-Nakagawa S, Miyagawa T, Sato K, Ogura H, Mori M, Wada T, Sakai Y, Yutani M, Matsumura T, Fujinaga Y, Gabata T, Wada T, Iwata Y.
    • Journal Title

      J Infect Chemother.

      Volume: 28 Issue: 5 Pages: 651-656

    • DOI

      10.1016/j.jiac.2022.01.015

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Protective Effect of D-Alanine Against Acute Kidney Injury.2022

    • Author(s)
      Iwata Y, Nakade Y, Kitajima S, Yoneda-Nakagawa S, Oshima M, Sakai N, Ogura H, Sato K, Toyama T, Yamamura Y, Miyagawa T,Yamazaki H, Hara A, Shimizu M, Furuichi K, Mita M, Hamase K, Tanaka T, Nishida M, Muramatsu W, Yamamoto H, Shichino S, Ueha S, Matsushima K, Wada T.
    • Journal Title

      Am J Physiol Renal Physiol.

      Volume: 322 Issue: 6 Pages: F667-F679

    • DOI

      10.1152/ajprenal.00198.2021

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Morphological and functional adaptation of pancreatic islet blood vessels to insulin resistance is impaired in diabetic db/db mice2022

    • Author(s)
      Okajima Yuka、Matsuzaka Takashi、Miyazaki Shun、Motomura Kaori、Ohno Hiroshi、Sharma Rahul、Shimura Takuya、Istiqamah Nurani、Han Song-iee、Mizunoe Yuhei、Osaki Yoshinori、Iwasaki Hitoshi、Yatoh Shigeru、Suzuki Hiroaki、Sone Hirohito、Miyamoto Takafumi、Aita Yuichi、Takeuchi Yoshinori、Sekiya Motohiro、Shimano Hitoshi
    • Journal Title

      Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease

      Volume: 1868 Issue: 4 Pages: 166339-166339

    • DOI

      10.1016/j.bbadis.2022.166339

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Human iPS cell-derived cartilaginous tissue spatially and functionally replaces nucleus pulposus2022

    • Author(s)
      Kamatani Takashi、Hagizawa Hiroki、Yarimitsu Seido、Morioka Miho、Koyamatsu Saeko、Sugimoto Michihiko、Kodama Joe、Yamane Junko、Ishiguro Hiroyuki、Shichino Shigeyuki、Abe Kuniya、Fujibuchi Wataru、Fujie Hiromichi、Kaito Takashi、Tsumaki Noriyuki
    • Journal Title

      Biomaterials

      Volume: 284 Pages: 121491-121491

    • DOI

      10.1016/j.biomaterials.2022.121491

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Moyamoya disease: diagnosis and interventions.2022

    • Author(s)
      Ihara M, Yamamoto Y, Hattori Y, Liu W, Kobayashi H, Ishiyama H, Yoshimoto T, Miyawaki S, Clausen T, Bang OY, Steinberg GK, Tournier-Lasserve E, Koizumi A.
    • Journal Title

      Lancet Neurology.

      Volume: -

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Suppression of RNF213, a susceptibility gene for moyamoya disease, inhibits endoplasmic reticulum stress through SEL1L upregulation2022

    • Author(s)
      Ahmed Sharif、Habu Toshiyuki、Kim Jiyeong、Okuda Hiroko、Oikawa Shinji、Murata Mariko、Koizumi Akio、Kobayashi Hatasu
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 609 Pages: 62-68

    • DOI

      10.1016/j.bbrc.2022.04.007

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Oridonin inhibits SASP by blocking p38 and NF-κB pathways in senescent cells2022

    • Author(s)
      Yasuda Shusuke、Horinaka Mano、Iizumi Yosuke、Goi Wakana、Sukeno Mamiko、Sakai Toshiyuki
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 590 Pages: 55-62

    • DOI

      10.1016/j.bbrc.2021.12.098

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Group IIA secreted phospholipase A2 controls skin carcinogenesis and psoriasis by shaping the gut microbiota2022

    • Author(s)
      Miki Yoshimi、Taketomi Yoshitaka、Kidoguchi Yuh、Yamamoto Kei、Muramatsu Kazuaki、Nishito Yasumasa、Park Jonguk、Hosomi Koji、Mizuguchi Kenji、Kunisawa Jun、Soga Tomoyoshi、Boilard Eric、B. Gowda Siddabasave Gowda、Ikeda Kazutaka、Arita Makoto、Murakami Makoto
    • Journal Title

      JCI Insight

      Volume: 7 Issue: 2

    • DOI

      10.1172/jci.insight.152611

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Secreted phospholipase A2 modifies extracellular vesicles and accelerates B cell lymphoma2022

    • Author(s)
      Kudo Kai、Miki Yoshimi、Carreras Joaquim、Nakayama Shunya、Nakamoto Yasushi、Ito Masatoshi、Nagashima Etsuko、Yamamoto Kei、Higuchi Hiroshi、Morita Shin-ya、Inoue Asuka、Aoki Junken、Ando Kiyoshi、Nakamura Naoya、Murakami Makoto、Kotani Ai
    • Journal Title

      Cell Metabolism

      Volume: 34 Issue: 4 Pages: 615-633

    • DOI

      10.1016/j.cmet.2022.02.011

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Group IVE cytosolic phospholipase A2 limits psoriatic inflammation by mobilizing the anti‐inflammatory lipid N‐acylethanolamine.2022

    • Author(s)
      Liang Luyiyun、Takamiya Rina、Miki Yoshimi、Heike Kanako、Taketomi Yoshitaka、Sugimoto Nao、Yamaguchi Midori、Shitara Hiroshi、Nishito Yasumasa、Kobayashi Tetsuyuki、Hirabayashi Tetsuya、Murakami Makoto
    • Journal Title

      The FASEB Journal

      Volume: 36 Issue: 5

    • DOI

      10.1096/fj.202101958r

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Molecular mechanism of crosstalk between immune and metabolic systems in metabolic syndrome2022

    • Author(s)
      Hachiya Rumi、Tanaka Miyako、Itoh Michiko、Suganami Takayoshi
    • Journal Title

      Inflammation and Regeneration

      Volume: 42 Issue: 1 Pages: 13-13

    • DOI

      10.1186/s41232-022-00198-7

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Glucocorticoid imprints a low glucose metabolism onto CD8 T cells and induces the persistent suppression of the immune response2022

    • Author(s)
      Konishi Amane、Suzuki Junpei、Kuwahara Makoto、Matsumoto Akira、Nomura Shunsuke、Soga Tomoyoshi、Yorozuya Toshihiro、Yamashita Masakatsu
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 588 Pages: 34-40

    • DOI

      10.1016/j.bbrc.2021.12.050

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] VDR regulates simulated microgravity-induced atrophy in C2C12 myotubes2022

    • Author(s)
      Yuzawa Ryo、Koike Hiroyuki、Manabe Ichiro、Oishi Yumiko
    • Journal Title

      Scientific Reports

      Volume: 12 Issue: 1 Pages: 1377-1377

    • DOI

      10.1038/s41598-022-05354-0

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Pirfenidone attenuates acetaminophen-induced liver injury via suppressing c-Jun N-terminal kinase phosphorylation2022

    • Author(s)
      Tashiro Shigeki、Tanaka Masatake、Goya Takeshi、Aoyagi Tomomi、Kurokawa Miho、Imoto Koji、Kuwano Akifumi、Takahashi Motoi、Suzuki Hideo、Kohjima Motoyuki、Kato Masaki、Ogawa Yoshihiro
    • Journal Title

      Toxicology and Applied Pharmacology

      Volume: 434 Pages: 115817-115817

    • DOI

      10.1016/j.taap.2021.115817

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The Combination of Nucleotide Analog Therapy and Steroid Pulse Therapy for Acute HBV Infection Effectively Promotes HBV Clearance2022

    • Author(s)
      Takeshi Goya, Tomoyuki Kurashige, Miho Kurokawa, Masatake Tanaka, Tomomi Aoyagi, Motoi Takahashi, Koji Imoto, Shigeki Tashiro, Hideo Suzuki, Masaki Kato, Motoyuki Kohjima, Yoshihiro Ogawa
    • Journal Title

      Gastroenterology Insights

      Volume: 13 Issue: 1 Pages: 1-8

    • DOI

      10.3390/gastroent13010001

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The Efficacy of Tofogliflozin onMetabolic Dysfunction-Associated Fatty Liver Disease2022

    • Author(s)
      Takeshi Goya, Koji Imoto, Shigeki Tashiro, Tomomi Aoyagi, Motoi Takahashi, Miho Kurokawa, Hideo Suzuki, Masatake Tanaka, Masaki Kato, Motoyuki Kohjima, Yoshihiro Ogawa
    • Journal Title

      Gastroenterology Insights

      Volume: 13 Issue: 1 Pages: 20-26

    • DOI

      10.3390/gastroent13010003

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Corticosteroid suppresses urea-cycle-related gene expressions in ornithine transcarbamylase deficiency2022

    • Author(s)
      Imoto Koji、Tanaka Masatake、Goya Takeshi、Aoyagi Tomomi、Takahashi Motoi、Kurokawa Miho、Tashiro Shigeki、Kato Masaki、Kohjima Motoyuki、Ogawa Yoshihiro
    • Journal Title

      BMC Gastroenterology

      Volume: 22 Issue: 1 Pages: 144-144

    • DOI

      10.1186/s12876-022-02213-0

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Essential roles of the transcription factor NR4A1 in regulatory T cell differentiation under the influence of immunosuppressants2022

    • Author(s)
      Takashi Sekiya, Hidenori Kasahara, Ryo Takemura, Shinya Fujita, Jun Kato, Noriko Doki, Yuta Katayama, Yukiyasu Ozawa, Satoru Takada, Tetsuya Eto, Takahiro Fukuda, Tatsuo Ichinohe, Minoko Takanashi, Makoto Onizuka, Yoshiko Atsuta, Shinichiro Okamoto, Akihiko Yoshimura, Satoshi Takaki, Takehiko Mori
    • Journal Title

      The Journal of Immunology

      Volume: in press Issue: 9 Pages: 2122-2130

    • DOI

      10.4049/jimmunol.2100808

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Comparison between Nr4a transcription factor regulation and function in lymphoid and tumor Treg cells2022

    • Author(s)
      Takashi Sekiya
    • Journal Title

      Frontiers in Immunology

      Volume: in press Pages: 866339-866339

    • DOI

      10.3389/fimmu.2022.866339

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The C-type lectin receptor Clec1A plays an important role in the development of experimental autoimmune encephalomyelitis by enhancing antigen presenting ability of dendritic cells and inducing inflammatory cytokine IL-172022

    • Author(s)
      MAKUSHEVA Yulia、CHUNG Soo-Hyun、AKITSU Aoi、MAEDA Natsumi、MARUHASHI Takumi、YE Xiao-Qi、KAIFU Tomonori、SAIJO Shinobu、SUN Haiyang、HAN Wei、TANG Ce、IWAKURA Yoichiro
    • Journal Title

      Experimental Animals

      Volume: 71 Issue: 3 Pages: 288-304

    • DOI

      10.1538/expanim.21-0191

    • NAID

      130008158392

    • ISSN
      0007-5124, 1341-1357, 1881-7122
    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] A Method for Detection of Markers for Epithelial-Mesenchymal Transition based on Single Cell Transcriptomic Data2022

    • Author(s)
      Kosho Murayama, Hideo Matsuda
    • Journal Title

      Proceedings of 12th International Conference on Bioscience, Biochemistry and Bioinformatics

      Volume: - Pages: 57-62

    • DOI

      10.1145/3510427.3510436

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Detection of Biomarkers for Epithelial-Mesenchymal Transition with Single-Cell Trajectory Inference2022

    • Author(s)
      Murayama Kosho、Matsuda Hideo
    • Journal Title

      Frontiers in Bioscience-Landmark

      Volume: 27 Issue: 4 Pages: 127-127

    • DOI

      10.31083/j.fbl2704127

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] TAS-Seq is a robust and sensitive amplification method for bead-based scRNA-seq.2022

    • Author(s)
      Shichino S, Ueha S, Hashimoto S, Ogawa T, Aoki H, Wu B, Chen CY, Kitabatake M, Ouji-Sageshima N, Sawabata N, Kawaguchi T, Okayama T, Sugihara E, Hontsu S, Ito T, Iwata Y, Wada T, Ikeo K, Sato T, Matsushima K.
    • Journal Title

      Communications Biology

      Volume: -

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Proportional Tumor Infiltration of T Cells <i>via</i> Circulation Duplicates the T Cell Receptor Repertoire in a Bilateral Tumor Mouse Model.2021

    • Author(s)
      Tsunoda M, Aoki H, Shimizu H, Shichino S, Matsushima K, Ueha S.
    • Journal Title

      Front Immunol.

      Volume: 12 Pages: 744381-744381

    • DOI

      10.3389/fimmu.2021.744381

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Macrophages in lung fibrosis.2021

    • Author(s)
      Ogawa T, Shichino S, Ueha S, Matsushima K.
    • Journal Title

      Int Immunol.

      Volume: 33 Issue: 12 Pages: 665-671

    • DOI

      10.1093/intimm/dxab040

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Greater extent of blood-tumor TCR repertoire overlap is associated with favorable clinical responses to PD-1 blockade.2021

    • Author(s)
      Aoki H, Ueha S, Nakamura Y, Shichino S, Nakajima H, Shimomura M, Sato A, Nakatsura T, Yoshino T, Matsushima K.
    • Journal Title

      Cancer Sci.

      Volume: 112 Issue: 8 Pages: 2993-3004

    • DOI

      10.1111/cas.14975

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Combining an alarmin HMGN1 peptide with PD-L1 blockade results in robust antitumor effects with a concomitant increase of stem-like/progenitor exhausted CD8+ T cells.2021

    • Author(s)
      Chen CY, Ueha S, Ishiwata Y, Shichino S, Yokochi S, Yang D, Oppenheim JJ, Ogiwara H, Deshimaru S, Kanno Y, Aoki H, Ogawa T, Shibayama S, Matsushima K.
    • Journal Title

      Cancer Immunol Res.

      Volume: 9 Issue: 10 Pages: 1214-1228

    • DOI

      10.1158/2326-6066.cir-21-0265

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Transient Depletion of CD4 + Cells Induces Remodeling of the TCR Repertoire in Gastrointestinal Cancer.2021

    • Author(s)
      Aoki H, Ueha S, Shichino S, Ogiwara H, Shitara K, Shimomura M, Suzuki T, Nakatsura T, Yamashita M, Kitano S, Kuroda S, Wakabayashi M, Kurachi M, Ito S, Doi T, Matsushima K.
    • Journal Title

      Cancer Immunol Res.

      Volume: - Issue: 6 Pages: 624-636

    • DOI

      10.1158/2326-6066.cir-20-0989

    • Related Report
      2021 Annual Research Report 2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] D-Serine inhibits the attachment and biofilm formation of methicillin-resistant Staphylococcus aureus2021

    • Author(s)
      Iwata Y, Sakai N, Yoneda I, Senda Y, Sakai-Takemori Y, Oshima M, Nakagawa-Yoneda S, Ogura H, Sato K, Minami T, Kitajima S, Toyama T, Yamamura Y, Miyagawa T, Hara A, Shimizu M, Furuichi K, Matsushima K, Wada T.
    • Journal Title

      Biochem Biophys Res Commun.

      Volume: 22 Pages: 50-56

    • DOI

      10.1016/j.bbrc.2020.12.078

    • Related Report
      2021 Annual Research Report 2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Starvation‐induced transcription factor CREBH negatively governs body growth by controlling GH signaling2021

    • Author(s)
      Nakagawa Yoshimi、Kumagai Kae、Han Song‐iee、Mizunoe Yuhei、Araki Masaya、Mizuno Seiya、Ohno Hiroshi、Matsuo Kazuya、Yamada Yasunari、Kim Jun‐dal、Miyamoto Takafumi、Sekiya Motohiro、Konishi Morichika、Itoh Nobuyuki、Matsuzaka Takashi、Takahashi Satoru、Sone Hirohito、Shimano Hitoshi
    • Journal Title

      The FASEB Journal

      Volume: 35 Issue: 6 Pages: 21663-21663

    • DOI

      10.1096/fj.202002784rr

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Genetic ablation of Nrf2 exacerbates neurotoxic effects of acrylamide in mice2021

    • Author(s)
      Ekuban Frederick Adams、Zong Cai、Takikawa Madoka、Morikawa Kota、Sakurai Toshihiro、Ichihara Sahoko、Itoh Ken、Yamamoto Masayuki、Ohsako Seiichiroh、Ichihara Gaku
    • Journal Title

      Toxicology

      Volume: 456 Pages: 152785-152785

    • DOI

      10.1016/j.tox.2021.152785

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Nrf2 Activation Attenuates Acrylamide-Induced Neuropathy in Mice2021

    • Author(s)
      Davuljigari Chand Basha、Ekuban Frederick Adams、Zong Cai、Fergany Alzahraa A. M.、Morikawa Kota、Ichihara Gaku
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 22 Issue: 11 Pages: 5995-5995

    • DOI

      10.3390/ijms22115995

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Role of Macrophages in Cytotoxicity, Reactive Oxygen Species Production and DNA Damage in 1,2-Dichloropropane-Exposed Human Cholangiocytes In Vitro2021

    • Author(s)
      Ekuban Abigail、Zong Cai、Ekuban Frederick Adams、Kimura Yusuke、Takizawa Ryoya、Morikawa Kota、Kinoshita Kazuo、Ichihara Sahoko、Ohsako Seiichiroh、Ichihara Gaku
    • Journal Title

      Toxics

      Volume: 9 Issue: 6 Pages: 128-128

    • DOI

      10.3390/toxics9060128

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] 1,2-Dichloropropane induces γ-H2AX expression in human cholangiocytes only in the presence of macrophages2021

    • Author(s)
      Takizawa Ryoya、Ichihara Sahoko、Zong Cai、Kinoshita Kazuo、Sakurai Toshihiro、Ikegami Akihiko、Mise Nathan、Ichihara Gaku
    • Journal Title

      Toxicology Letters

      Volume: 349 Pages: 134-144

    • DOI

      10.1016/j.toxlet.2021.06.009

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] AMPK activation reverts mouse epiblast stem cells to naive state2021

    • Author(s)
      Liu Yajing、Yamane Junko、Tanaka Akito、Fujibuchi Wataru、Yamashita Jun K.
    • Journal Title

      iScience

      Volume: 24 Issue: 7 Pages: 102783-102783

    • DOI

      10.1016/j.isci.2021.102783

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Time-Series Analysis of Gene Correlation Networks based on Single-Cell Transcriptome Data2021

    • Author(s)
      Asano Yasuhito、Ogawa Tatsuro、Shichino Shigeyuki、Ueha Satoshi、Matsushima Koji、Ogura Atsushi
    • Journal Title

      2021 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)

      Volume: - Pages: 2134-2141

    • DOI

      10.1109/bibm52615.2021.9669412

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Mast cell-specific deletion of group III secreted phospholipase A2 impairs mast cell maturation and functions2021

    • Author(s)
      Taketomi Y, Endo Y, Higashi T, Murase R, Ono T, Taya C, Kobayashi T, Murakami M.
    • Journal Title

      Cells

      Volume: 10 Issue: 7 Pages: 1691-1691

    • DOI

      10.3390/cells10071691

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The sodium-glucose cotransporter-2 inhibitor Tofogliflozin prevents the progression of nonalcoholic steatohepatitis-associated liver tumors in a novel murine model.2021

    • Author(s)
      Yoshioka N, Tanaka M, Ochi K, Watanabe A, Ono K, Sawada M, Ogi T, Itoh M, Ito A, Shiraki Y, Enomoto A, Ishigami M, Fujishiro M, Ogawa Y, Suganami T.
    • Journal Title

      Biomed Pharmacother

      Volume: 140 Pages: 111738-111738

    • DOI

      10.1016/j.biopha.2021.111738

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Dietary Supplementation With Eicosapentaenoic Acid Inhibits Plasma Cell Differentiation and Attenuates Lupus Autoimmunity2021

    • Author(s)
      Kobayashi Azusa、Ito Ayaka、Shirakawa Ibuki、Tamura Atsushi、Tomono Susumu、Shindou Hideo、Hedde Per Niklas、Tanaka Miyako、Tsuboi Naotake、Ishimoto Takuji、Akashi-Takamura Sachiko、Maruyama Shoichi、Suganami Takayoshi
    • Journal Title

      Frontiers in Immunology

      Volume: 12 Pages: 650856-650856

    • DOI

      10.3389/fimmu.2021.650856

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Macrophages rely on extracellular serine to suppress aberrant cytokine production2021

    • Author(s)
      Kurita Kento、Ohta Hiroya、Shirakawa Ibuki、Tanaka Miyako、Kitaura Yasuyuki、Iwasaki Yorihiro、Matsuzaka Takashi、Shimano Hitoshi、Aoe Seiichiro、Arima Hiroshi、Ogawa Yoshihiro、Ito Ayaka、Suganami Takayoshi
    • Journal Title

      Scientific Reports

      Volume: 11 Issue: 1 Pages: 11137-11137

    • DOI

      10.1038/s41598-021-90086-w

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The Loss of H3K27 Histone Demethylase Utx in T Cells Aggravates Allergic Contact Dermatitis2021

    • Author(s)
      Inoue Takashi、Omori-Miyake Miyuki、Maruyama Saho、Okabe Masataka、Kuwahara Makoto、Honda Hiroaki、Miura Hiromasa、Yamashita Masakatsu
    • Journal Title

      The Journal of Immunology

      Volume: 207 Issue: 9 Pages: 2223-2234

    • DOI

      10.4049/jimmunol.2001160

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Identification of a KLF5-dependent program and drug development for skeletal muscle atrophy2021

    • Author(s)
      Liu L, Koike H, Ono T, Hayashi S, Kudo F, Kaneda A, Kagechika H, Manabe I, Nakashima T, Oishi, Y.
    • Journal Title

      Proc Natl Acad Sci U S A.

      Volume: 118 Issue: 35

    • DOI

      10.1073/pnas.2102895118

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Microcirculatory disturbance in acute liver injury2021

    • Author(s)
      Kuwano Akifumi、Kurokawa Miho、Kohjima Motoyuki、Imoto Koji、Tashiro Shigeki、Suzuki Hideo、Tanaka Masatake、Okada Seiji、Kato Masaki、Ogawa Yoshihiro
    • Journal Title

      Experimental and Therapeutic Medicine

      Volume: 21 Issue: 6 Pages: 596-596

    • DOI

      10.3892/etm.2021.10028

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Ovalbumin-Induced Airway Inflammation Is Ameliorated in Dectin-1?Deficient Mice, in Which Pulmonary Regulatory T Cells Are Expanded through Modification of Intestinal Commensal Bacteria2021

    • Author(s)
      Han Wei、Tang Ce、Baba Seiya、Hamada Tomofumi、Shimazu Tomoyuki、Iwakura Yoichiro
    • Journal Title

      The Journal of Immunology

      Volume: 206 Issue: 9 Pages: 1991-2000

    • DOI

      10.4049/jimmunol.2001337

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] DCIR and its ligand asialo-biantennary N-glycan regulate DC function and osteoclastogenesis2021

    • Author(s)
      Kaifu Tomonori、Yabe Rikio、Maruhashi Takumi、Chung Soo-Hyun、Tateno Hiroaki、Fujikado Noriyuki、Hirabayashi Jun、Iwakura Yoichiro
    • Journal Title

      Journal of Experimental Medicine

      Volume: 218 Issue: 12 Pages: 1-10

    • DOI

      10.1084/jem.20210435

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Interleukin-17 family members in health and disease2021

    • Author(s)
      Chung Soo-Hyun、Ye Xiao-Qi、Iwakura Yoichiro
    • Journal Title

      International Immunology

      Volume: 33 Issue: 12 Pages: 723-729

    • DOI

      10.1093/intimm/dxab075

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] The CTRP3-AdipoR2 Axis Regulates the Development of Experimental Autoimmune Encephalomyelitis by Suppressing Th17 Cell Differentiation2021

    • Author(s)
      Murayama Masanori A.、Chi Hsi-Hua、Matsuoka Mako、Ono Takahiro、Iwakura Yoichiro
    • Journal Title

      Frontiers in Immunology

      Volume: 12 Pages: 607346-607346

    • DOI

      10.3389/fimmu.2021.607346

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Nerve?macrophage interactions in cardiovascular disease2021

    • Author(s)
      Fujiu Katsuhito、Manabe Ichiro
    • Journal Title

      International Immunology

      Volume: 34 Issue: 2 Pages: 81-95

    • DOI

      10.1093/intimm/dxab036

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Cardiac macrophages prevent sudden death during heart stress.2021

    • Author(s)
      Sugita J, Fujiu K, Nakayama Y, Matsubara T, Matsuda J, Oshima T, Liu Y, Maru Y, Hasumi E, Kojima T, Seno H, Asano K, Ishijima A, Tomii N, Yamazaki M, Kudo F, Sakuma I, Nagai R, Manabe I, Komuro I.
    • Journal Title

      Nat Commun.

      Volume: 12(1) Issue: 1 Pages: 1910-1910

    • DOI

      10.1038/s41467-021-22178-0

    • Related Report
      2021 Annual Research Report 2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Detecting Lineage-Specific Marker Genes for Tumor Evolution Based on Single Cell Transcriptome2021

    • Author(s)
      Murayama Kosho、Graduate School of Information Science and Technology, Osaka University, Suita, Osaka, Japan、Matsuda Hideo
    • Journal Title

      International Journal of Bioscience, Biochemistry and Bioinformatics

      Volume: 11 Issue: 3 Pages: 50-57

    • DOI

      10.17706/ijbbb.2021.11.3.50-57

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A CNN-based cell tracking method for multi-slice intravital imaging data2021

    • Author(s)
      Fujimoto Kenji、Mizugaki Tsubasa、Rajkumar Utkrisht、Shigeta Hironori、Seno Shigeto、Uchida Yutaka、Ishii Masaru、Bafna Vineet、Matsuda Hideo
    • Journal Title

      Proceedings of the 12th ACM Conference on Bioinformatics, Computational Biology, and Health Informatics

      Volume: 35 Pages: 1-7

    • DOI

      10.1145/3459930.3469559

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Diet intake control is indispensable for the gluconeogenic response to sodium-glucose cotransporter 2 inhibition in male mice2021

    • Author(s)
      Hashiuchi E, Watanabe H, Kimura K, Matsumoto M, Inoue H, Inaba Y
    • Journal Title

      Journal of Diabetes Investigation

      Volume: 12 Issue: 1 Pages: 35-47

    • DOI

      10.1111/jdi.13319

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Extracellular DJ-1 induces sterile inflammation in the ischemic brain.2021

    • Author(s)
      Nakamura K, Sakai S, Tsuyama J, Nakamura A, Otani K, Kurabayashi K, Yogiashi Y, Masai H, Shichita T
    • Journal Title

      PLOS Biol

      Volume: 19 Issue: 5 Pages: e3000939-e3000939

    • DOI

      10.1371/journal.pbio.3000939

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] TP53/p53-FBXO22-TFEB controls basal autophagy to govern hormesis2021

    • Author(s)
      Suzuki Narumi、Johmura Yoshikazu、Wang Teh-Wei、Migita Toshiro、Wu Wenwen、Noguchi Rei、Yamaguchi Kiyoshi、Furukawa Yoichi、Nakamura Shuhei、Miyoshi Ichiro、Yoshimori Tamotsu、Ohta Tomohiko、Nakanishi Makoto
    • Journal Title

      Autophagy

      Volume: 11 Issue: 11 Pages: 1-18

    • DOI

      10.1080/15548627.2021.1897961

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Senolysis by glutaminolysis inhibition ameliorates various age-associated disorders2021

    • Author(s)
      Johmura Yoshikazu、Yamanaka Takehiro、Omori Satotaka、Wang Teh-Wei、Sugiura Yuki、Matsumoto Masaki、Suzuki Narumi、Kumamoto Soichiro、Yamaguchi Kiyoshi、Hatakeyama Seira、Takami Tomoyo、Yamaguchi Rui、Shimizu Eigo、Ikeda Kazutaka、Okahashi Nobuyuki、Mikawa Ryuta、Suematsu Makoto、Arita Makoto、Sugimoto Masataka et al
    • Journal Title

      Science

      Volume: 371 Issue: 6526 Pages: 265-270

    • DOI

      10.1126/science.abb5916

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Iron-rich Kupffer cells exhibit phenotypic changes during the development of liver fibrosis in NASH.2021

    • Author(s)
      Kanamori Y, Tanaka M, Itoh M, Ochi K, Ito A, Hidaka I, Sakaida I, Ogawa Y, Suganami T
    • Journal Title

      iScience

      Volume: 24 Issue: 2 Pages: 2102032-2102032

    • DOI

      10.1016/j.isci.2020.102032

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Enterohepatic Transcription Factor CREB3L3 Protects Atherosclerosis via SREBP Competitive Inhibition2021

    • Author(s)
      Nakagawa Yoshimi、Wang Yunong、Han Song-iee、Okuda Kanako、Oishi Asayo、Yagishita Yuka、Kumagai Kae、Ohno Hiroshi、Osaki Yoshinori、Mizunoe Yuhei、Araki Masaya、Murayama Yuki、Iwasaki Hitoshi、Konishi Morichika、Itoh Nobuyuki、Matsuzaka Takashi、Sone Hirohito、Yamada Nobuhiro、Shimano Hitoshi
    • Journal Title

      Cellular and Molecular Gastroenterology and Hepatology

      Volume: 11 Issue: 4 Pages: 949-971

    • DOI

      10.1016/j.jcmgh.2020.11.004

    • NAID

      120006939158

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Regulation of peripheral Th/Treg differentiation and suppression of airway inflammation by Nr4a transcription factors.2021

    • Author(s)
      Takashi Sekiya, Shizuko Kagawa, Katsunori Masaki, Koichi Fukunaga, Akihiko Yoshimura, Satoshi Takaki .
    • Journal Title

      iScience.

      Volume: 24 Issue: 3 Pages: 102166-102166

    • DOI

      10.1016/j.isci.2021.102166

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] LECT2 as a hepatokine links liver steatosis to inflammation via activating tissue macrophages in NASH2021

    • Author(s)
      Takata Noboru、Ishii Kiyo-aki、Takayama Hiroaki、Nagashimada Mayumi、Kamoshita Kyoko、Tanaka Takeo、Kikuchi Akihiro、Takeshita Yumie、Matsumoto Yukako、Ota Tsuguhito、Yamamoto Yasuhiko、Yamagoe Satoshi、Seki Akihiro、Sakai Yoshio、Kaneko Shuichi、Takamura Toshinari
    • Journal Title

      Scientific Reports

      Volume: 11 Issue: 1 Pages: 555-555

    • DOI

      10.1038/s41598-020-80689-0

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Chemoprevention with low-dose aspirin, mesalazine, or both in patients with familial adenomatous polyposis without previous colectomy (J-FAPP Study IV): a multicentre, double-blind, randomised, two-by-two factorial design trial2021

    • Author(s)
      Ishikawa H、Mutoh M、Sato Y、Doyama H、Tajika M、Tanaka S、Horimatsu T、Takeuchi Y、Kashida H、Tashiro J、Ezoe Y、Nakajima T、Ikematsu H、Hori S、Suzuki S、Otani T、Takayama T、Ohda Y、Mure K、Wakabayashi K、Sakai T
    • Journal Title

      The Lancet Gastroenterology & Hepatology

      Volume: - Issue: 6 Pages: 474-481

    • DOI

      10.1016/s2468-1253(21)00018-2

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] γ-Glutamylcyclotransferase, a novel regulator of HIF-1α expression, triggers aerobic glycolysis2021

    • Author(s)
      Taniguchi Keiko、Kageyama Susumu、Moyama Chiami、Ando Shota、Ii Hiromi、Ashihara Eishi、Horinaka Mano、Sakai Toshiyuki、Kubota Shigehisa、Kawauchi Akihiro、Nakata Susumu
    • Journal Title

      Cancer Gene Therapy

      Volume: - Issue: 1 Pages: 37-48

    • DOI

      10.1038/s41417-020-00287-0

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Rabdosianone I, a Bitter Diterpene from an Oriental Herb, Suppresses Thymidylate Synthase Expression by Directly Binding to ANT2 and PHB22021

    • Author(s)
      Watanabe M, Yamada Y, Kurumida Y, Kameda T, Sukeno M, Iizuka-Ohashi M, Sowa Y, Iizumi Y, Takakura H, Miyamoto S, Sakai T, Mutoh M.
    • Journal Title

      Cancers.

      Volume: 13 Issue: 5 Pages: 982-982

    • DOI

      10.3390/cancers13050982

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Establishment of bioluminescent imaging model using murine T cell lymphoma susceptive to NK cell-dependent immune-surveillance.2021

    • Author(s)
      Fujiwara T, Miyazato K, Takahashi K, Hayakawa Y.
    • Journal Title

      J Immunol Methods.

      Volume: 491 Pages: 112993-112993

    • DOI

      10.1016/j.jim.2021.112993

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] UBC13 is an RNF213-associated E2 ubiquitin-conjugating enzyme, and Lysine 63-linked ubiquitination by the RNF213UBC13 axis is responsible for angiogenic activity.2021

    • Author(s)
      Habu T, Harada K
    • Journal Title

      FASEB Bioadv.

      Volume: 3 Issue: 4 Pages: 243-258

    • DOI

      10.1096/fba.2019-00092

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] RNF213 as a Susceptibility Gene for Moyamoya Disease has Multifunctional Roles in Biological Processes2021

    • Author(s)
      Hatasu Kobayashi, Kouji H. Harada, Toshiyuki Habu, Yasuhisa Nakamura, Jiyeong Kim, Akio Koizumi
    • Journal Title

      Kuroda S. (eds) Moyamoya Disease: Current Knowledge and Future Perspectives.

      Volume: - Pages: 47-60

    • DOI

      10.1007/978-981-33-6404-2_4

    • ISBN
      9789813364035, 9789813364042
    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Anti-metastatic Effects of Baicalein by Targeting STAT3 Activity in Breast Cancer Cells2020

    • Author(s)
      Susmitha Gorrepotu D, Miyazato K, Ogura K, Yokoyama S, Hayakawa Y.
    • Journal Title

      Biological and Pharmaceutical Bulletin

      Volume: 43 Issue: 12 Pages: 1899-1905

    • DOI

      10.1248/bpb.b20-00571

    • NAID

      130007948716

    • ISSN
      0918-6158, 1347-5215
    • Year and Date
      2020-12-01
    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Generation of a p16 Reporter Mouse and Its Use to Characterize and Target p16high Cells In Vivo.2020

    • Author(s)
      Omori S, Wang TW, Johmura Y, ..., Sakamoto T (15番目), ..., Nakanishi M.
    • Journal Title

      Cell Metab

      Volume: 32 Issue: 5 Pages: 814-828

    • DOI

      10.1016/j.cmet.2020.09.006

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] A long noncoding RNA regulates inflammation resolution by mouse macrophages through fatty acid oxidation activation2020

    • Author(s)
      Nakayama Yukiteru、Fujiu Katsuhito、Yuki Ryuzaburo、Oishi Yumiko、Morioka Masaki Suimye、Isagawa Takayuki、Matsuda Jun、Oshima Tsukasa、Matsubara Takumi、Sugita Junichi、Kudo Fujimi、Kaneda Atsushi、Endo Yusuke、Nakayama Toshinori、Nagai Ryozo、Komuro Issei、Manabe Ichiro
    • Journal Title

      Proceedings of the National Academy of Sciences

      Volume: 117 Issue: 25 Pages: 14365-14375

    • DOI

      10.1073/pnas.2005924117

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Organ system crosstalk in cardiometabolic disease in the age of multimoribidity2020

    • Author(s)
      Oishi Y, Manabe I
    • Journal Title

      Frontiers in Cardiovascluar Medicine

      Volume: - Pages: 64-64

    • DOI

      10.3389/fcvm.2020.00064

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Human Cell Atlas and cell-type authentication for regenerative medicine.2020

    • Author(s)
      Yulia Panina, Peter Karagiannis, Andreas Kurtz, Glyn N. Stacey, Wataru Fujibuchi.
    • Journal Title

      Exp Mol Med.

      Volume: 52 Issue: 9 Pages: 1443-1451

    • DOI

      10.1038/s12276-020-0421-1

    • NAID

      120006892055

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Proteomic analysis of liver proteins of mice exposed to 1,2-dichloropropane.2020

    • Author(s)
      Zhang X, Morikawa K, Mori Y, Zong C, Zhang L, Garner E, Huang C, Wu W, Chang J, Nagashima D, Sakurai T, Ichihara S, Oikawa S, Ichihara G.
    • Journal Title

      Arch Toxicol.

      Volume: 94 Issue: 8 Pages: 2691-2705

    • DOI

      10.1007/s00204-020-02785-4

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] C-type lectin Mincle mediates cell death-triggered inflammation in acute kidney injury.2020

    • Author(s)
      Tanaka M, Saka-Tanaka M, Ochi K, Fujieda K, Sugiura Y, Miyamoto T, Kohda H, Ito A, Miyazawa T, Matsumoto A, Aoe S, Miyamoto Y, Tsuboi N, Maruyama S, Suematsu M, Yamasaki S, Ogawa Y, Suganami T.
    • Journal Title

      J Exp Med.

      Volume: 217 Issue: 11

    • DOI

      10.1084/jem.20192230

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Characterization of radioresistant epithelial stem cell heterogeneity in the damaged mouse intestine.2020

    • Author(s)
      Sato T, Sase M, Ishikawa S, Kajita M, Asano J, Sato T, Mori Y, and Ohteki T.
    • Journal Title

      Sci Rep

      Volume: 10 Issue: 1 Pages: 8308-8308

    • DOI

      10.1038/s41598-020-64987-1

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Pathogenicity Characterization of Prevalent-Type Streptococcus dysgalactiae subsp. equisimilis Strains2020

    • Author(s)
      Matsue Miki、Ogura Kohei、Sugiyama Hironori、Miyoshi-Akiyama Tohru、Takemori-Sakai Yukiko、Iwata Yasunori、Wada Takashi、Okamoto Shigefumi
    • Journal Title

      Frontiers in Microbiology

      Volume: 11 Pages: 97-97

    • DOI

      10.3389/fmicb.2020.00097

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The increased frequency of methicillin-resistant Staphylococcus aureus with low MIC of beta-lactam antibiotics isolated from hospitalized patients2020

    • Author(s)
      Iwata Y、Sakai N、Yoneda I、Satou K、Furuichi K、Senda Y、Sakai-Takemori Y、Wada T、Fujita S、Ogura H、Sato K、Minami T、Yamaguchi K、Kitajima S、Toyama T、Yamamura Y、Miyagawa T、Hara A、Shimizu M、Sakai Y、Ikeo K、Shichino S、Ueha S、Nakajima T、Matsushima K、Wada T
    • Journal Title

      Journal of Infection and Chemotherapy

      Volume: 26 Issue: 6 Pages: 604-610

    • DOI

      10.1016/j.jiac.2020.01.016

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Hepatocyte ELOVL Fatty Acid Elongase 6 Determines Ceramide Acyl‐Chain Length and Hepatic Insulin Sensitivity in Mice2020

    • Author(s)
      Matsuzaka T、Kuba M、Koyasu S、Yamamoto Y、Motomura K、Arulmozhiraja S、Ohno H、Sharma R、Shimura T、Okajima Y、Han SI、Aita Y、Mizunoe Y、Osaki Y、Iwasaki H、Yatoh S、Suzuki H、Sone H、Takeuchi Y、Yahagi N、Miyamoto T、Sekiya M、Nakagawa Y、Ema M、Takahashi S、Tokiwa H、Shimano H
    • Journal Title

      Hepatology

      Volume: 71 Issue: 5 Pages: 1609-1625

    • DOI

      10.1002/hep.30953

    • NAID

      120007132717

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] CREBH Improves Diet-Induced Obesity, Insulin Resistance, and Metabolic Disturbances by FGF21-Dependent and FGF21-Independent Mechanisms2020

    • Author(s)
      Satoh Aoi、Han Song-iee、Araki Masaya、Nakagawa Yoshimi、Ohno Hiroshi、Mizunoe Yuhei、Kumagai Kae、Murayama Yuki、Osaki Yoshinori、Iwasaki Hitoshi、Sekiya Motohiro、Konishi Morichika、Itoh Nobuyuki、Matsuzaka Takashi、Sone Hirohito、Shimano Hitoshi
    • Journal Title

      iScience

      Volume: 23 Issue: 3 Pages: 100930-100930

    • DOI

      10.1016/j.isci.2020.100930

    • NAID

      120006891020

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Deactivation of Glutaminolysis Sensitizes PIK3CA-Mutated Colorectal Cancer Cells to Aspirin-Induced Growth Inhibition.2020

    • Author(s)
      Boku S, Watanabe M, Sukeno M, Yaoi T, Hirota K, Iizuka-Ohashi M, Itoh K, Sakai T.
    • Journal Title

      Cancers (Basel).

      Volume: 12 Issue: 5 Pages: 1097-1097

    • DOI

      10.3390/cancers12051097

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The Novel Histone Deacetylase Inhibitor, OBP-801, Induces Apoptosis in Rhabdoid Tumors by Releasing the Silencing of NOXA.2020

    • Author(s)
      Sugimoto Y, Katsumi Y, Iehara T, Kaneda D, Tomoyasu C, Ouchi K, Yoshida H, Miyachi M, Yagyu S, Kikuchi K, Tsuchiya K, Kuwahara Y, Sakai T, Hosoi H.
    • Journal Title

      Mol Cancer Ther.

      Volume: 19 Issue: 10 Pages: 1992-2000

    • DOI

      10.1158/1535-7163.mct-20-0243

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Synergistic effect of the inhibitors of RAF/MEK and AXL on KRAS-mutated ovarian cancer cells with high AXL expression.2020

    • Author(s)
      Umemura S, Sowa Y, Iizumi Y, Kitawaki J, Sakai T.
    • Journal Title

      Cancer Sci.

      Volume: 111 Issue: 6 Pages: 2052-2061

    • DOI

      10.1111/cas.14414

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Very long-term treatment with a Lactobacillus probiotic preparation, Lactobacillus Casei strain Shirota, suppresses weight loss in the elderly.2020

    • Author(s)
      Ishikawa H, Mutoh M, Yoshimura K, Fujii G, Nakamura T, Takeshita T, Wakabayashi K, Sakai T.
    • Journal Title

      Nutrients

      Volume: 12 Issue: 6 Pages: 1599-1599

    • DOI

      10.3390/nu12061599

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Artesunate Inhibits Intestinal Tumorigenesis through Inhibiting Wnt Signaling.2020

    • Author(s)
      Hamoya T, Fujii G, Iizumi Y, Narita T, Komiya M, Matsuzawa Y, Miki K, Kondo T, Kishimoto S, Watanabe K, Wakabayashi K, Sakai T, Toshima J, Mutoh M
    • Journal Title

      Carcinogenesis

      Volume: 42 Issue: 1 Pages: 148-58

    • DOI

      10.1093/carcin/bgaa084

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Anti-Metastatic Effects of Curcumin Analogues in a Mouse Breast Cancer Model2020

    • Author(s)
      Ucche S, Murwanti R, Ritmaleni, Hayakawa Y.
    • Journal Title

      BPB Reports

      Volume: 3 Issue: 2 Pages: 76-79

    • DOI

      10.1248/bpbreports.3.2_76

    • NAID

      130007944871

    • ISSN
      2434-432X
    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Pharmacological targeting of natural killer cells for cancer immunotherapy.2020

    • Author(s)
      Miyazato K, Hayakawa Y.
    • Journal Title

      Cancer Sci.

      Volume: 111 Issue: 6 Pages: 1869-1875

    • DOI

      10.1111/cas.14418

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Antimetastatic effects of thalidomide by inducing the functional maturation of peripheral natural killer cells2020

    • Author(s)
      Miyazato K, Tahara H, Hayakawa Y.
    • Journal Title

      Cancer Sci.

      Volume: 111 Issue: 8 Pages: 2770-2778

    • DOI

      10.1111/cas.14538

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Anti&#8209;inflammatory compounds moracin O and P from Morus alba Linn. (Sohakuhi) target the NF&#8209;κB pathway.2020

    • Author(s)
      Hardianti B, Umeyama L, Li F, Yokoyama S, Hayakawa Y.
    • Journal Title

      Mol Med Rep.

      Volume: 22 Issue: 6 Pages: 5385-5391

    • DOI

      10.3892/mmr.2020.11615

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Anti-inflammatory effect of fermented brown rice and rice bran with Aspergillus oryzae on mice.2020

    • Author(s)
      Umeyama L, Kasahara S, Sugawara M, Yokoyama S, Saiki I, Hayakawa Y.
    • Journal Title

      Traditional & Kampo Medicine.

      Volume: 8 Issue: 1 Pages: 60-65

    • DOI

      10.1002/tkm2.1270

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Collagen adhesion gene is associated with bloodstream infections caused by methicillin-resistant Staphylococcus aureus.2020

    • Author(s)
      Iwata Y, Satou K, Furuichi K, Yoneda I, Matsumura T, et al.
    • Journal Title

      Int J Infect Dis.

      Volume: 91 Pages: 22-31

    • DOI

      10.1016/j.ijid.2019.11.003

    • NAID

      120006842044

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Tracking and Analysis of FUCCI-Labeled Cells Based on Particle Filters and Time-to-Event Analysis.2020

    • Author(s)
      Fujimoto, K., Seno, S., Shigeta, H., Mashita, T., Ishii, M., Matsuda, H.
    • Journal Title

      Int J Biosci Biochem Bioinforma.

      Volume: 10 Issue: 2 Pages: 94-109

    • DOI

      10.17706/ijbbb.2020.10.2.94-109

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Glycolysis and subsequent mevalonate biosynthesis play an important role in Th2 cell differentiation.2020

    • Author(s)
      Yagi Y, Kuwahara M, Suzuki J, Imai Y and Yamashita M.
    • Journal Title

      Biochem Biophys Res Commun.

      Volume: 530 Issue: 2 Pages: 355-361

    • DOI

      10.1016/j.bbrc.2020.08.009

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] T cell-specific deletion of Pgam1 reveals a critical role for glycolysis in T cell responses.2020

    • Author(s)
      Toriyama K, Kuwahara M, Kondoh H, Mikawa T, Takemori N, Konishi A., Yorozuya T, Yamada T, Soga T., Shiraishi A, and Yamashita M.
    • Journal Title

      Communications Biology

      Volume: 3 Issue: 1 Pages: 1-13

    • DOI

      10.1038/s42003-020-01122-w

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Composition Proposal Generation for Manga Creation Support.2020

    • Author(s)
      Hironori Ito, Yasuhito Asano.
    • Journal Title

      IEICE Trans. Inf. Syst.

      Volume: 103-D Pages: 949-957

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] IL-1β Plays an Important Role in Pressure Overload-Induced Atrial Fibrillation in Mice2019

    • Author(s)
      Matsushita N, Ishida N, Ibi M, Saito M, Takahashi M, Taniguchi S, Iwakura Y, Morino Y, Taira E, Sawa Y, Hirose M
    • Journal Title

      Biological and Pharmaceutical Bulletin

      Volume: 42 Issue: 4 Pages: 543-546

    • DOI

      10.1248/bpb.b18-00363

    • NAID

      130007622152

    • ISSN
      0918-6158, 1347-5215
    • Year and Date
      2019-04-01
    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Circulating Concentrations of Insulin Resistance-Associated Hepatokines, Selenoprotein P and Leukocyte Cell-Derived Chemotaxin 2, during an Oral Glucose Tolerance Test in Humans2019

    • Author(s)
      Mohri K, Misu H, Takayama H, Ishii KA, Kikuchi A, Lan F, Enyama Y, Takeshita Y, Saito Y, Kaneko S,Takamura T.
    • Journal Title

      Biological and Pharmaceutical Bulletin

      Volume: 42 Issue: 3 Pages: 373-378

    • DOI

      10.1248/bpb.b18-00549

    • NAID

      130007607371

    • ISSN
      0918-6158, 1347-5215
    • Year and Date
      2019-03-01
    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Analyzing Leukocyte Migration Trajectories by Deformable Image Matching2019

    • Author(s)
      Shigeta Hironori、Seno Shigeto、Nishizawa Shino、Uchida Yutaka、Kikuta Junichi、Ishii Masaru、Matsuda Hideo
    • Journal Title

      IEEE Xplore

      Volume: 19243594 Pages: 94-98

    • DOI

      10.1109/bibe.2019.00025

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Single-cell transcriptome analysis of mouse leukocytes in inflammatory stimulation.2019

    • Author(s)
      Osato N, Shigeta H, Seno S, Uchida Y, Kikuta J, Ishii M, Matsuda H.
    • Journal Title

      IEEE Xplore

      Volume: 19351527 Pages: 1229-1231

    • DOI

      10.1109/bibm47256.2019.8983394

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Lipopolysaccharide-induced Expansion of Histidine Decarboxylase-Expressing Ly6G + Myeloid Cells Identified by Exploiting Histidine Decarboxylase BAC-GFP Transgenic Mice2019

    • Author(s)
      Takai J, Ohtsu H, Sato A, Uemura S, Fujimura T, Yamamoto M, Moriguchi T.
    • Journal Title

      Sci Rep.

      Volume: 9(1) Issue: 1 Pages: 15603-15603

    • DOI

      10.1038/s41598-019-51716-6

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Epidermal loss of phospholipase Cδ1 attenuates irritant contact dermatitis2019

    • Author(s)
      Shiratori K, Kanemaru K, Ogura T, Nakajima A, Sugizaki Y, Fukuyama T, Iwakura Y, Nakamura Y, Fukami K.
    • Journal Title

      Biochem Biophys Res Commun.

      Volume: 511 Issue: 2 Pages: 330-335

    • DOI

      10.1016/j.bbrc.2019.02.046

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Spontaneous atopic dermataitis in mice with a defective skin barrier is independent of ILC2 and mediated by IL-1β.2019

    • Author(s)
      Schwartz, C., Moran, T., Saunders, S. P., Kaszlikowska, A., Floudas, A., Bom, J., Nunez, G., Iwakura, Y., O’Neill, L., Irvine, A. D., McKenzie, A. N. J., Ogg, G., Walsh, P. T., Demengeot, J., and Fallon, P. G.
    • Journal Title

      Allergy

      Volume: 74 Issue: 10 Pages: 1920-1933

    • DOI

      10.1111/all.13801

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Myeloid C-type lectin receptors in skin/mucoepithelial diseases and tumors.2019

    • Author(s)
      Tang, C., Makusheva, Y., Sun, H., Han, W., and Iwakura, Y.
    • Journal Title

      J. Leukoc. Biol.

      Volume: 106 Issue: 4 Pages: 903-917

    • DOI

      10.1002/jlb.2ri0119-031r

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Uncoupling the senescence-associated secretory phenotype from cell cycle exit via IL-1 inactivation unveils its pro-tumorigenic role.2019

    • Author(s)
      Lau, L., Porciuncula, A., Yu, A., Iwakura, Y., and David, G.
    • Journal Title

      Mol. Cell Biol.

      Volume: 39 Issue: 12 Pages: 18-35

    • DOI

      10.1128/mcb.00586-18

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] arge scale cacium imaging of the cerebellar vermis during sensory stimulus unravels two response’s components that differ in their spatiotemporal properties.2019

    • Author(s)
      Byk, H., Huang, G. J., Iwakura, Y., and Yarom, Y.
    • Journal Title

      Front. Syst. Neurosci.

      Volume: 13 Pages: 18-18

    • DOI

      10.3389/fnsys.2019.00018

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] CARD9+ microglia promote antifungal immunity via IL-1β- and CXCL1-mediated neutrophil recruitment.2019

    • Author(s)
      Drummond, R. A., Swamydas, M., Oikonomou, V., Zhai, B., Dambuza, I. M., Schaefer, B. C., Bohrer, A. C., Mayer-Barber, K. D., Lira, S. A., Iwakura, Y., Filler, S. G., Brown, G. D., Hube, B., Naglik, J. R., Hohl, T. M., and Lionakis, M. S.
    • Journal Title

      Nat Immunol.

      Volume: 20 Issue: 5 Pages: 559-570

    • DOI

      10.1038/s41590-019-0377-2

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Dectin-2?induced CCL2 production in tissue-resident macrophages ignites cardiac arteritis2019

    • Author(s)
      Miyabe Chie、Miyabe Yoshishige、Bricio-Moreno Laura、Lian Jeffrey、Rahimi Rod A.、Miura Noriko N.、Ohno Naohito、Iwakura Yoichiro、Kawakami Tamihiro、Luster Andrew D.
    • Journal Title

      Journal of Clinical Investigation

      Volume: 129 Issue: 9 Pages: 3610-3624

    • DOI

      10.1172/jci123778

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] CCR8 leads to eosinophil migration and regulates neutrophil migration in murine allergic enteritis.2019

    • Author(s)
      Blanco-Perez, F., Kato, Y., Gonzalez-Menendez, I., Laino, J., Ohbayashi, M., Burggraf, M., Krause, M., Kirberg, J., Iwakura, Y., Martella, M., Quintanilla-Martinez, L., Shibata, N., Vieths, S., Scheurer, S., and Toda, M.
    • Journal Title

      Sci. Rep.

      Volume: 9 Issue: 1 Pages: 9608-9608

    • DOI

      10.1038/s41598-019-45653-7

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] AIM2 inflammasome-derived IL-1β induces postoperative ileus in mice.2019

    • Author(s)
      Hupa, K. J., Stein, K., Schneider, R., Lysson, M., Schneiker, B., Hornung, V., Latz, E., Iwakura, Y., Kalff, J. C., and Wehner, S.
    • Journal Title

      Sci. Rep.

      Volume: 9 Issue: 1 Pages: 10602-10602

    • DOI

      10.1038/s41598-019-46968-1

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Cutaneous p38 mitogen-activated protein kinase activation triggers psoriatic dermatitis.2019

    • Author(s)
      Sakurai K, Dainichi T, Garcet S, Tsuchiya S, Yamamoto Y, Kitoh A, Honda T, Nomura T, Egawa G, Otsuka A, Nakajima S, Matsumoto R, Nakano Y, Otsuka M, Iwakura Y, Grinberg-Bleyer Y, Ghosh S, Sugimoto Y, Guttman-Yassky E, Krueger JG, Kabashima K.
    • Journal Title

      J Allergy Clin Immunol

      Volume: 144(4) Issue: 4 Pages: 1036-1049

    • DOI

      10.1016/j.jaci.2019.06.019

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Defect of interferon γ leads to impaired wound healing through prolonged neutrophilic inflammatory response and enhanced MMP-2 activation.2019

    • Author(s)
      Kanno E, Tanno H, Masaki A, Sasaki A, Sato N, Goto M, Shisai M, Yamaguchi K, Takagi N, Shoji M, Kitai Y, Sato K, Kasamatsu J, Ishii K, Miyasaka T, Kawakami K, Imai Y, Iwakura Y, Maruyama R, Tachi M, Kawakami K.
    • Journal Title

      Int. J. Mol. Sci.

      Volume: 20(22) Issue: 22 Pages: 5657-5657

    • DOI

      10.3390/ijms20225657

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Pevonedistat, a Neuronal Precursor Cell-Expressed Developmentally Down-Regulated Protein 8-Activating Enzyme Inhibitor, Is a Potent Inhibitor of Hepatitis B Virus2019

    • Author(s)
      Sekiba Kazuma、Otsuka Motoyuki、Ohno Motoko、Yamagami Mari、Kishikawa Takahiro、Seimiya Takahiro、Suzuki Tatsunori、Tanaka Eri、Ishibashi Rei、Funato Kazuyoshi、Koike Kazuhiko
    • Journal Title

      Hepatology

      Volume: in press Issue: 5 Pages: 1903-1915

    • DOI

      10.1002/hep.30491

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Liver stiffness measurements in chronic hepatitis C: Treatment evaluation and risk assessment2019

    • Author(s)
      Nakagomi R, Tateishi R, Masuzaki R, Soroida Y, Iwai T, Kondo M, Fujiwara N, Sato M, Minami T, Uchino K, Enooku K, Nakagawa H, Asaoka Y, Kondo Y, Tanaka Y, Otsuka M, Kato N, Moriya K, Ikeda H, Koike K.
    • Journal Title

      Gastroenterol Hepatol.

      Volume: 34 Issue: 5 Pages: 921

    • DOI

      10.1111/jgh.14530

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Cdk1-mediated DIAPH1 phosphorylation maintains metaphase cortical tension and inactivates the spindle assembly checkpoint at anaphase.2019

    • Author(s)
      Nishimura K, Johmura Y, Deguchi K, Jiang Z, Uchida KSK, Suzuki N, Shimada M, Chiba Y, Hirota T, Yoshimura SH, Kono K, Nakanishi M.
    • Journal Title

      Nature Communications

      Volume: 10 Issue: 1 Pages: 1-10

    • DOI

      10.1038/s41467-019-08957-w

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Identification and isolation of splenic tissue resident macrophage subpopulations by flow cytometry2019

    • Author(s)
      Fujiyama S, Nakahashi-Oda C, Abe F, Wang Y, Sato K, Shibuya A
    • Journal Title

      Int Immunol

      Volume: 31(1) Issue: 1 Pages: 51-56

    • DOI

      10.1093/intimm/dxy064

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Serum aldo-keto reductase family 1 member B10 predicts advanced liver fibrosis and fatal complications of nonalcoholic steatohepatitis.2019

    • Author(s)
      M Kanno, K Kawaguchi, M Honda, R Horii, H Takatori, T Shimakami, K Kitamura, K Arai, T Yamashita, Y Sakai, T Yamashita, E Mizukoshi, S Kaneko.
    • Journal Title

      J Gastroenterol

      Volume: - Issue: 6 Pages: 549-557

    • DOI

      10.1007/s00535-019-01551-3

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The Cortical Neuroimmune Regulator TANK Affects Emotional Processing and Enhances Alcohol Drinking: A Translational Study2019

    • Author(s)
      Muller CP, Chu C, Qin L, Liu C, Xu B, Gao H, Ruggeri B, Hieber S, Schneider J, Jia T, Tay N, Akira S, Satoh T, Banaschewski T, Bokde ALW, Bromberg U, Buchel C, Quinlan EB, Flor H, Frouin V, Garavan H, Gowland P, Heinz A, Ittermann B, Martinot JL, Martinot MP, Artiges E, Lemaitre H, Nees F, ..., Schumann G.
    • Journal Title

      Cerebral Cortex

      Volume: 29 Issue: 4 Pages: 1736-1751

    • DOI

      10.1093/cercor/bhy341

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Heterozygous Tbk1 loss has opposing effects in early and late stages of ALS in mice.2019

    • Author(s)
      Brenner D, Sieverding K, Bruno C, Luningschror P, Buck E, Mungwa S, Fischer L, Brockmann SJ, Ulmer J, Bliederhauser C, Philibert CE, Satoh T, Akira S, Boillee S, Mayer B, Sendtner M, Ludolph AC, Danzer KM, Lobsiger CS, Freischmidt A, Weishaupt JH.
    • Journal Title

      J Exp Med.

      Volume: 216 Issue: 2 Pages: 267-278

    • DOI

      10.1084/jem.20180729

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] USP15 Participates in Hepatitis C Virus Propagation through Regulation of Viral RNA Translation and Lipid Droplet Formation2019

    • Author(s)
      Kusakabe S、Suzuki T、Sugiyama Y、Haga S、Horike K、Tokunaga M、Hirano J、Zhang H、Chen DV、Ishiga H、Komoda Y、Ono C、Fukuhara T、Yamamoto M、Ikawa M、Satoh T、Akira S、Tanaka T、Moriishi Ki、Fukai M、Taketomi A、Yoshio S、Kanto T、Suzuki T、Okamoto T、Matsuura Y
    • Journal Title

      Journal of Virology

      Volume: 93 Issue: 6 Pages: 1708-1718

    • DOI

      10.1128/jvi.01708-18

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Clonal analysis revealed functional heterogeneity in cancer stem-like cell phenotypes in uterine endometrioid adenocarcinoma.2019

    • Author(s)
      Tabuchi Y, Hirohashi Y, Hashimoto S, Mariya T, Asano T, Ikeo K, Kuroda T, Mizuuchi M, Murai A, Uno S, Kawai N, Kubo T, Nakatsugawa M, Kanaseki T, Tsukahara T, Saito T, Torigoe T.
    • Journal Title

      Exp Mol Pathol

      Volume: 106 Pages: 78-88

    • DOI

      10.1016/j.yexmp.2018.11.013

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Engraftment and proliferation potential of embryonic lung tissue cells in irradiated mice with emphysema2019

    • Author(s)
      Shiraishi Kazushige、Shichino Shigeyuki、Tsukui Tatsuya、Hashimoto Shinichi、Ueha Satoshi、Matsushima Kouji
    • Journal Title

      Scientific Reports

      Volume: 9 Issue: 1 Pages: 1-12

    • DOI

      10.1038/s41598-019-40237-x

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Combined treatment with HMGN1 and anti-CD4 depleting antibody reverses T cell exhaustion and exerts robust anti-tumor effects in mice2019

    • Author(s)
      Chen Chang-Yu、Ueha Satoshi、Ishiwata Yoshiro、Yokochi Shoji、Yang De、Oppenheim Joost J.、Ogiwara Haru、Shichino Shigeyuki、Deshimaru Shungo、Shand Francis H. W.、Shibayama Shiro、Matsushima Kouji
    • Journal Title

      Journal for ImmunoTherapy of Cancer

      Volume: 7 Issue: 1 Pages: 21-21

    • DOI

      10.1186/s40425-019-0503-6

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Cryptococcus gattii alters immunostimulatory potential in response to the environment2019

    • Author(s)
      Ueno Keigo、Otani Yoshiko、Yanagihara Nao、Nakamura Takumi、Shimizu Kiminori、Yamagoe Satoshi、Miyazaki Yoshitsugu
    • Journal Title

      PLOS ONE

      Volume: 14 Issue: 8 Pages: 265-276

    • DOI

      10.1371/journal.pone.0220989

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Histone H3K27 Demethylase Negatively Controls the Memory Formation of Antigen-Stimulated CD8+ T Cells2019

    • Author(s)
      Yamada Takeshi、Nabe Shogo、Toriyama Koji、Suzuki Junpei、Inoue Kazuki、Imai Yuuki、Shiraishi Atsushi、Takenaka Katsuto、Yasukawa Masaki、Yamashita Masakatsu
    • Journal Title

      The Journal of Immunology

      Volume: 202 Issue: 4 Pages: 1088-1098

    • DOI

      10.4049/jimmunol.1801083

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Toxicological Evaluation of SiO2 Nanoparticles by Zebrafish Embryo Toxicity Test2019

    • Author(s)
      Vranic Sandra、Shimada Yasuhito、Ichihara Sahoko、Kimata Masayuki、Wu Wenting、Tanaka Toshio、Boland Sonja、Tran Lang、Ichihara Gaku
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 20 Issue: 4 Pages: 882-882

    • DOI

      10.3390/ijms20040882

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Mutant KCNJ3 and KCNJ5 potassium channels as novel molecular targets in bradyarrhythmias and atrial fibrillation.2019

    • Author(s)
      Yamada N, Asano Y, Fujita M, Yamazaki S, Inanobe A, Matsuura N, Kobayashi H, Ohno S, Ebana Y, Tsukamoto O, Ishino S, Takuwa A, Kioka H, Yamashita T, Hashimoto N, Zankov DP, Shimizu A, Asakura M, Asanuma H, Kato H, Nishida Y, Miyashita Y, Shinomiya H, Naiki N, Hayashi K, Makiyama T, Ogita H, et al.
    • Journal Title

      Circulation

      Volume: In press Issue: 18 Pages: 2157-2169

    • DOI

      10.1161/circulationaha.118.036761

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Characteristics of Japanese Patients with Nonvalvular Atrial Fibrillation on Anticoagulant Treatment: A Descriptive Analysis of J-dabigatran Surveillance and JAPAF Study.2019

    • Author(s)
      Koretsune Y, Kusakawa K, Harada KH, Koizumi A, Uchiyama S, Atarashi H, Okumura K, Yasaka M, Yamashita T, Taniguchi A, Fukaya T, Inoue H; for J-dabigatran surveillance and JAPAF study investigators.
    • Journal Title

      Cardiol Ther.

      Volume: 8 Issue: 1 Pages: 43-54

    • DOI

      10.1007/s40119-019-0129-2

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Moyamoya Disease Susceptibility Variant RNF213 p.R4810K Increases the Risk of Ischemic Stroke Attributable to Large-Artery Atherosclerosis2019

    • Author(s)
      Okazaki S, Koizumi A 他26名(27番目)
    • Journal Title

      Circulation

      Volume: 139 Issue: 2 Pages: 295-298

    • DOI

      10.1161/circulationaha.118.038439

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Glucocorticoid receptor suppresses gene expression of Rev-erbα (Nr1d1) through interaction with the CLOCK complex2019

    • Author(s)
      Murayama Yuki, Takafumi Miyamoto, et al.
    • Journal Title

      FEBS Letters

      Volume: 593 Issue: 4 Pages: 423-432

    • DOI

      10.1002/1873-3468.13328

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Role of eosinophils in a murine model of inflammatory bowel disease.2019

    • Author(s)
      Wang Z, Adachi S, Kong L, Watanabe D, Nakanishi Y, Ohteki T, Hoshi N, Kodama Y.
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 511 Issue: 1 Pages: 99-104

    • DOI

      10.1016/j.bbrc.2019.02.056

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Transcriptome network analysis identifies protective role of the LXR/SREBP-1c axis in murine pulmonary fibrosis.2019

    • Author(s)
      Shichino S, Ueha S, Hashimoto S, Otsuji M, Abe J, Tsukui T, Deshimaru S, Nakajima T, Kosugi-Kanaya M, Shand FH, Inagaki Y, Shimano H, Matsushima K.
    • Journal Title

      JCI Insight.

      Volume: 4(1) Issue: 1 Pages: 122163-122163

    • DOI

      10.1172/jci.insight.122163

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Inhibition of HBV Transcription From cccDNA With Nitazoxanide by Targeting the HBx?DDB1 Interaction2019

    • Author(s)
      Sekiba Kazuma、Otsuka Motoyuki、Ohno Motoko、Yamagami Mari、Kishikawa Takahiro、Suzuki Tatsunori、Ishibashi Rei、Seimiya Takahiro、Tanaka Eri、Koike Kazuhiko
    • Journal Title

      Cellular and Molecular Gastroenterology and Hepatology

      Volume: 7 Issue: 2 Pages: 297-312

    • DOI

      10.1016/j.jcmgh.2018.10.010

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Role of interleukin-17 in a murine community-associated methicillin-resistant Staphylococcus aureus pneumonia model2019

    • Author(s)
      Shibue Yasushi、Kimura Soichiro、Kajiwara Chiaki、Iwakura Yoichiro、Yamaguchi Keizo、Tateda Kazuhiro
    • Journal Title

      Microbes and Infection

      Volume: 21 Issue: 1 Pages: 33-39

    • DOI

      10.1016/j.micinf.2018.06.006

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Dectin-2-Mediated Signaling Leads to Delayed Skin Wound Healing through Enhanced Neutrophilic Inflammatory Response and Neutrophil Extracellular Trap Formation.2019

    • Author(s)
      Miura T, Kawakami K, Kanno E, Tanno H, Tada H, Sato N, Masaki A, Yokoyama R, Kawamura K, Kitai Y, Takagi N, Yamaguchi K, Yamaguchi N, Kyo Y, Ishii K, Imai Y, Saijo S, Iwakura Y, Tachi M.
    • Journal Title

      J Invest Dermatol

      Volume: 139(3) Issue: 3 Pages: 702-711

    • DOI

      10.1016/j.jid.2018.10.015

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Dectin-1 Contributes to Myocardial Ischemia/Reperfusion Injury by Regulating Macrophage Polarization and Neutrophil Infiltration2019

    • Author(s)
      Fan Qin、Tao Rong、Zhang Hang、Xie Hongyang、Lu Lin、Wang Ting、Su Min、Hu Jian、Zhang Qi、Chen Qiujing、Iwakura Yoichiro、Shen Weifeng、Zhang Ruiyan、Yan Xiaoxiang
    • Journal Title

      Circulation

      Volume: 139 Issue: 5 Pages: 663-678

    • DOI

      10.1161/circulationaha.118.036044

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Higher pulse pressure predicts initiation of dialysis in Japanese patients with diabetes2019

    • Author(s)
      Osawa Taeko、Fujihara Kazuya、Harada Mayuko、Yamamoto Masahiko、Ishizawa Masahiro、Suzuki Hiroshi、Ishiguro Hajime、Matsubayashi Yasuhiro、Seida Hiroyasu、Yamanaka Nauta、Tanaka Shiro、Shimano Hitoshi、Kodama Satoru、Sone Hirohito
    • Journal Title

      Diabetes/Metabolism Research and Reviews

      Volume: 35 Issue: 3

    • DOI

      10.1002/dmrr.3120

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Mesenchymal-Epithelial Interactome Analysis Reveals Essential Factors Required for Fibroblast-Free Alveolosphere Formation2019

    • Author(s)
      Shiraishi Kazushige、Shichino Shigeyuki、Ueha Satoshi、Nakajima Takuya、Hashimoto Shinichi、Yamazaki Satoshi、Matsushima Kouji
    • Journal Title

      iScience

      Volume: 11 Pages: 318-333

    • DOI

      10.1016/j.isci.2018.12.022

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Occupational Exposure Limits for ethylidene norbornene, ethyleneimine, benomyl, and 2,3-epoxypropyl methacrylate, and classifications on carcinogenicity2018

    • Author(s)
      Committee for Recommendation of Occupational Exposure Limits, Japan Society for Occupational Health, Araki A, Azuma K, Endo G, Endo Y, Fukushima T, Hara K, Hori H, Horie S, Horiguchi H, Ichiba M, Ichihara G, Ikeda M, Ishitake T, Ito A, Ito Y, Iwasawa S, Kakumu T, Kamijima M, Karita K.
    • Journal Title

      Journal of Occupational Health

      Volume: 60 Issue: 4 Pages: 333-335

    • DOI

      10.1539/joh.2018-0137-OP

    • NAID

      130007420038

    • ISSN
      1341-9145, 1348-9585
    • Year and Date
      2018-07-20
    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Comparison of Human Selenoprotein P Determinants in Serum between Our Original Methods and Commercially Available Kits2018

    • Author(s)
      Saito Yoshiro、Misu Hirofumi、Takayama Hiroaki、Takashima Shin-ichiro、Usui Soichiro、Takamura Masayuki、Kaneko Shuichi、Takamura Toshinari、Noguchi Noriko
    • Journal Title

      Biological and Pharmaceutical Bulletin

      Volume: 41 Issue: 5 Pages: 828-832

    • DOI

      10.1248/bpb.b18-00046

    • NAID

      130006730702

    • ISSN
      0918-6158, 1347-5215
    • Year and Date
      2018-05-01
    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] TAK1 Prevents Endothelial Apoptosis and Maintains Vascular Integrity.2018

    • Author(s)
      Naito H, Iba T, Wakabayashi T, Tai-Nagara I, Suehiro JI, Jia W, Eino D, Sakimoto S, Muramatsu F, Kidoya H, Sakurai H, Satoh T, Akira S, Kubota Y, Takakura N.
    • Journal Title

      Dev Cell.

      Volume: 48 Issue: 2 Pages: 151-166

    • DOI

      10.1016/j.devcel.2018.12.002

    • Related Report
      2019 Annual Research Report 2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] ISGF3 with reduced phosphorylation is associated with constitutive expression of interferon-induced genes in aging cells2018

    • Author(s)
      Yamagami Mari、Otsuka Motoyuki、Kishikawa Takahiro、Sekiba Kazuma、Seimiya Takahiro、Tanaka Eri、Suzuki Tatsunori、Ishibashi Rei、Ohno Motoko、Koike Kazuhiko
    • Journal Title

      npj Aging and Mechanisms of Disease

      Volume: 4 Issue: 1 Pages: 11-11

    • DOI

      10.1038/s41514-018-0030-6

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Inflammation and de-differentiation in pancreatic carcinogenesis2018

    • Author(s)
      Seimiya Takahiro、Otsuka Motoyuki、Iwata Takuma、Tanaka Eri、Suzuki Tatsunori、Sekiba Kazuma、Yamagami Mari、Ishibashi Rei、Koike Kazuhiko
    • Journal Title

      World Journal of Clinical Cases

      Volume: 6 Issue: 15 Pages: 882-891

    • DOI

      10.12998/wjcc.v6.i15.882

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Angiopoietin-2 exacerbates cardiac hypoxia and inflammation after myocardial infarction2018

    • Author(s)
      Lee Seung-Jun、Lee Choong-kun、Kang Seok、Park Intae、Kim Yoo Hyung、Kim Seo Ki、Hong Seon Pyo、Bae Hosung、He Yulong、Kubota Yoshiaki、Koh Gou Young
    • Journal Title

      Journal of Clinical Investigation

      Volume: 128 Issue: 11 Pages: 5018-5033

    • DOI

      10.1172/jci99659

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Hematopoietic insults damage bone marrow niche by activating p53 in vascular endothelial cells.2018

    • Author(s)
      Si S, Nakajima-Takagi Y, Iga T, Tsuji M, Hou L, Oshima M, Koide S, Saraya A, Yamazaki S, Takubo K, Kubota Y, Minamino T, Iwama A.
    • Journal Title

      Exp Hematol

      Volume: 63 Pages: 41-51

    • DOI

      10.1016/j.exphem.2018.04.006

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Degradation of the endoplasmic reticulum-anchored transcription factor MyRF by the ubiquitin ligase SCFFbxw7 in a manner dependent on the kinase GSK-3.2018

    • Author(s)
      Nakayama S, Yumimoto K, Kawamura A, Nakayama KI.
    • Journal Title

      J. Biol. Chem.

      Volume: 293(15) Issue: 15 Pages: 5705-5714

    • DOI

      10.1074/jbc.ra117.000741

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Efficient Generation of Small Intestinal Epithelial-like Cells from Human iPSCs for Drug Absorption and Metabolism Studies2018

    • Author(s)
      Negoro Ryosuke、Takayama Kazuo、Kawai Kanae、Harada Kazuo、Sakurai Fuminori、Hirata Kazumasa、Mizuguchi Hiroyuki
    • Journal Title

      Stem Cell Reports

      Volume: 11 Issue: 6 Pages: 1539-1550

    • DOI

      10.1016/j.stemcr.2018.10.019

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Fbxo22-mediated KDM4B degradation determines selective estrogen receptor modulator activity in breast cancer.2018

    • Author(s)
      Johmura Y, Maeda I, Suzuki N, Wu W, Goda A,Morita M, Yamaguchi K, Yamamoto M, Nagasawa S, Kojima Y, Tsugawa K, Inoue N, Miyoshi Y, Osako T Akiyama F, Maruyama R, Inoue JI, Fukukawa Y, Ohta T, Nkanishi M.
    • Journal Title

      J Clin Invest.

      Volume: 128 Issue: 12 Pages: 5603-5619

    • DOI

      10.1172/jci121679

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Isozyme-Specific Role of SAD-A in Neuronal Migration During Development of Cerebral Cortex2018

    • Author(s)
      Nakanishi Keiko、Niida Hiroyuki、Tabata Hidenori、Ito Tsuyoshi、Hori Yuki、Hattori Madoka、Johmura Yoshikazu、Yamada Chisato、Ueda Takashi、Takeuchi Kosei、Yamada Kenichiro、Nagata Koh-ichi、Wakamatsu Nobuaki、Kishi Masashi、Pan Y Albert、Ugawa Shinya、Shimada Shoichi、Sanes Joshua R、Higashi Yujiro、Nakanishi Makoto
    • Journal Title

      Cerebral Cortex

      Volume: 160 Issue: 9 Pages: 721-721

    • DOI

      10.1093/cercor/bhy253

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Production of low-molecular weight soluble yeast β-glucan by an acid degradation method2018

    • Author(s)
      Ishimoto Yuina、Ishibashi Ken-ichi、Yamanaka Daisuke、Adachi Yoshiyuki、Kanzaki Ken、Iwakura Yoichiro、Ohno Naohito
    • Journal Title

      International Journal of Biological Macromolecules

      Volume: 107 Pages: 2269-2278

    • DOI

      10.1016/j.ijbiomac.2017.10.094

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] IL-1R2 deficiency suppresses dextran sodium sulfate-induced colitis in mice via regulation of microbiota.2018

    • Author(s)
      Yoshida, K., Murayama, M., Shimizu, K., Tang, C., Katagiri, N., Matsuo, K., Fukai F., and Iwakura, Y.
    • Journal Title

      Biochem. Biophys. Res. Commun.

      Volume: 496 Issue: 3 Pages: 934-940

    • DOI

      10.1016/j.bbrc.2018.01.116

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] HER2 overexpression triggers an IL-1α pro-inflammatory circuit to drive tumorigenesis and promote chemotherapy resistance.2018

    • Author(s)
      Liu, S., Lee, J. S., Jie, C., Park, M. H., Iwakura, Y., Patel, Y., Soni, M., Reisman, D., and Chen, H.
    • Journal Title

      Cancer Res.

      Volume: - Issue: 8 Pages: 2040-2051

    • DOI

      10.1158/0008-5472.can-17-2761

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Establishment and analysis of a novel mouse line carrying a conditional knockin allele of a cancer-specific FBXW7 mutation.2018

    • Author(s)
      Ikenoue T, Terakado Y, Zhu C, Liu X, Ohsugi T, Matsubara D, Fujii T, Kakuta S,Kubo S, Shibata T, Yamaguchi K, Iwakura Y, Furukawa Y.
    • Journal Title

      Sci Rep

      Volume: 8 Issue: 1 Pages: 2021-2021

    • DOI

      10.1038/s41598-018-19769-1

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Myeloid-derived interleukin-1β drives oncogenic KRAS-NF-κΒ addiction in malignant pleural effusion2018

    • Author(s)
      Marazioti A, Lilis I, Vreka M, Apostolopoulou H, Kalogeropoulou A, Giopanou I, Giotopoulou GA, Krontira AC, Iliopoulou M, Kanellakis NI, Agalioti T, Giannou AD, Jones-Paris C, Iwakura Y, Kardamakis D, Blackwell TS, Taraviras S, Spella M, Stathopoulos GT.
    • Journal Title

      Nature Communications

      Volume: 9 Issue: 1 Pages: 672-672

    • DOI

      10.1038/s41467-018-03051-z

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Host defense against oral microbiota by bone-damaging T cells2018

    • Author(s)
      Tsukasaki Masayuki、Komatsu Noriko、Nagashima Kazuki、Nitta Takeshi、Pluemsakunthai Warunee、Shukunami Chisa、Iwakura Yoichiro、Nakashima Tomoki、Okamoto Kazuo、Takayanagi Hiroshi
    • Journal Title

      Nature Communications

      Volume: 9 Issue: 1 Pages: 701-701

    • DOI

      10.1038/s41467-018-03147-6

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Increased mTOR cancels out the effect of reduced Xbp-1 on antibody secretion in IL-1α-deficient B cells2018

    • Author(s)
      Zhu Gaizhi、Liu Xiaoling、Fang Ying、Zhai Bing、Xu Ruonan、Han Gencheng、Chen Guojiang、Xiao He、Hou Chunmei、Shen Beifen、Li Yan、Iwakura Yoichiro、Wang Liang、Jiang Zhenyu、Ma Ning、Liu Guangchao、Wang Renxi
    • Journal Title

      Cellular Immunology

      Volume: 328 Pages: 9-17

    • DOI

      10.1016/j.cellimm.2018.02.015

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] IL-25 enhances Th17 cell-mediated contact dermatitis by promoting IL-1b production by dermal dendritic cells2018

    • Author(s)
      Suto H, Nambu A, Morita H, Yamaguchi S, Numata T, Yoshizaki T, Shimura E, Arae K, Asada Y, Motomura K, Kaneko M, Abe T, Matsuda A, Iwakura Y, Okumura K, Saito H, Matsumoto K, Sudo K, Nakae S
    • Journal Title

      J Allergy Clin Immunol

      Volume: In press Issue: 5 Pages: 1500-1509

    • DOI

      10.1016/j.jaci.2017.12.1007

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Apaf1 plays a negative regulatory role in T cell responses by suppressing activation of antigen-stimulated T cells.2018

    • Author(s)
      Tong, H., Miyake, Y., Mi-Ichi, F., Iwakura, Y., Hara, H. and Yoshida, H.
    • Journal Title

      PLoS One

      Volume: 13 Issue: 3 Pages: 0195119-0195119

    • DOI

      10.1371/journal.pone.0195119

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] A model of TH17-associated ileal hyperplasia that requires both IL-17A and IFNγ to generate self-tolerance and prevent colitis2018

    • Author(s)
      Jeschke Jonathan C.、Mayne Christopher G.、Ziegelbauer Jennifer、DeCiantis Christopher L.、Singh Selina、Kumar Suresh N.、Suchi Mariko、Iwakura Yoichiro、Drobyski William R.、Salzman Nita H、Williams Calvin B.
    • Journal Title

      Mucosal Immunology

      Volume: 11 Issue: 4 Pages: 1127-1137

    • DOI

      10.1038/s41385-018-0023-6

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] IL-36α from Skin-Resident Cells Plays an Important Role in the Pathogenesis of Imiquimod-Induced Psoriasiform Dermatitis by Forming a Local Autoamplification Loop.2018

    • Author(s)
      Hashiguchi Y, Yabe R, Chung SH, Murayama MA, Yoshida K, Matsuo K, Kubo S, Saijo S, Nakamura Y, Matsue H, Iwakura Y.
    • Journal Title

      J Immunol.

      Volume: 201 Issue: 1 Pages: 167-182

    • DOI

      10.4049/jimmunol.1701157

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Inhibition of interleukin-1 suppresses angiotensin II-induced aortic inflammation and aneurysm formation.2018

    • Author(s)
      Isoda K, Akita K, Kitamura K, Sato-Okabayashi Y, Kadoguchi T, Isobe S, Ohtomo F, Sano M, Shimada K, Iwakura Y, Daida H
    • Journal Title

      Int J Cardiol

      Volume: 270 Pages: 221-227

    • DOI

      10.1016/j.ijcard.2018.05.072

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] BAFF inhibition attenuates fibrosis in scleroderma by modulating the regulatory and effector B cell balance2018

    • Author(s)
      Matsushita Takashi、Kobayashi Tadahiro、Mizumaki Kie、Kano Miyu、Sawada Tomoyo、Tennichi Momoko、Okamura Ai、Hamaguchi Yasuhito、Iwakura Yoichiro、Hasegawa Minoru、Fujimoto Manabu、Takehara Kazuhiko
    • Journal Title

      Science Advances

      Volume: 4 Issue: 7 Pages: 9944-9944

    • DOI

      10.1126/sciadv.aas9944

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] MAIT cells protect against pulmonary Legionella longbeachae infection2018

    • Author(s)
      Wang H, D'Souza C, Lim XY, Kostenko L, Pediongco TJ, Eckle SBG, Meehan BS, Shi M, Wang N, Li S, Liu L, Mak JYW, Fairlie DP, Iwakura Y, Gunnersen JM, Stent AW, Godfrey DI, Rossjohn J, Westall GP, Kjer-Nielsen L, Strugnell RA, McCluskey J, Corbett AJ, Hinks TSC, Chen Z.
    • Journal Title

      Nature Communications

      Volume: 9 Issue: 1 Pages: 3350-3350

    • DOI

      10.1038/s41467-018-05202-8

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] The ATP Transporter VNUT Mediates Induction of Dectin-1-Triggered Candida Nociception.2018

    • Author(s)
      Maruyama K, Takayama Y, Sugisawa E, Yamanoi Y, Yokawa T, Kondo T, Ishibashi KI, Sahoo BR, Takemura N, Mori Y, Kanemaru H, Kumagai Y, Martino MM, Yoshioka Y, Nishijo H, Tanaka H, Sasaki A, Ohno N, Iwakura Y, Moriyama Y, Nomura M, Akira S, Tominaga M.
    • Journal Title

      iScience

      Volume: 6 Pages: 306-318

    • DOI

      10.1016/j.isci.2018.08.007

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] IL-36α is involved in hapten-specific T-cell induction, but not local inflammation, during contact hypersensitivity2018

    • Author(s)
      Numata Takafumi、Yoshizaki Takamichi、Yamaguchi Sachiko、Shimura Eri、Iwakura Yoichiro、Harada Kazutoshi、Sudo Katsuko、Tsuboi Ryoji、Nakae Susumu
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 506 Issue: 3 Pages: 429-436

    • DOI

      10.1016/j.bbrc.2018.10.104

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] IL-6, IL-17 and Stat3 are required for auto-inflammatory syndrome development in mouse.2018

    • Author(s)
      Oike T, Kanagawa H, Sato Y, Kobayashi T, Nakatsukasa H, Miyamoto K, Nakamura S, Kaneko Y, Kobayashi S, Harato K, Yoshimura A, Iwakura Y, Takeuchi T, Matsumoto M, Nakamura M, Niki Y, Miyamoto T.
    • Journal Title

      Sci Rep.

      Volume: - Issue: 1 Pages: 15783-15783

    • DOI

      10.1038/s41598-018-34173-5

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] TLR-stimulated IRAKM activates caspase-8 inflammasome in microglia and promotes neuroinflammation2018

    • Author(s)
      Zhang Cun-Jin、Jiang Meiling、Zhou Hao、Liu Weiwei、Wang Chenhui、Kang Zizhen、Han Bing、Zhang Quanri、Chen Xing、Xiao Jianxin、Fisher Amanda、Kaiser William J.、Murayama Masanori A.、Iwakura Yoichiro、Gao Ji、Carman Julie、Dongre Ashok、Dubyak George、Abbott Derek W.、Shi Fu-Dong、Ransohoff Richard M.、Li Xiaoxia
    • Journal Title

      Journal of Clinical Investigation

      Volume: 128 Issue: 12 Pages: 5399-5412

    • DOI

      10.1172/jci121901

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Allergy inhibitory receptor‐1 inhibits autoantibody production via upregulation of apoptotic debris clearance by macrophages2018

    • Author(s)
      Iizuka Akira、Segawa Seiji、Kondo Yuya、Kaneko Shunta、Yokosawa Masahiro、Furuyama Kotona、Miki Haruka、Tahara‐Hanaoka Satoko、Shibuya Akira、Tsuboi Hiroto、Goto Daisuke、Matsumoto Isao、Shibayama Shiro、Sumida Takayuki
    • Journal Title

      International Journal of Rheumatic Diseases

      Volume: 21 Issue: 12 Pages: 2071-2078

    • DOI

      10.1111/1756-185x.13381

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Exploring the Gut Fungi-Lung Allergy Axis2018

    • Author(s)
      Shibuya Akira、Shibuya Kazuko
    • Journal Title

      Cell Host & Microbe

      Volume: 24 Issue: 6 Pages: 755-757

    • DOI

      10.1016/j.chom.2018.11.012

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Elovl6 regulates mechanical damage-induced keratinocyte death and skin inflammation.2018

    • Author(s)
      Nakamura Y, Matsuzaka T, Tahara-Hanaoka S, Shibuya K, Shimano H, Nakahashi-Oda C, Shibuya A.
    • Journal Title

      Cell Death Dis.

      Volume: 9(12) Issue: 12 Pages: 1181-1181

    • DOI

      10.1038/s41419-018-1226-1

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Forebrain Ptf1a Is Required for Sexual Differentiation of the Brain2018

    • Author(s)
      Fujiyama Tomoyuki、Miyashita Satoshi、Tsuneoka Yousuke、Kanemaru Kazumasa、Kakizaki Miyo、Kanno Satomi、Ishikawa Yukiko、Yamashita Mariko、Owa Tomoo、Nagaoka Mai、Kawaguchi Yoshiya、Yanagawa Yuchio、Magnuson Mark A.、Muratani Masafumi、Shibuya Akira、Nabeshima Yo-ichi、Yanagisawa Masashi、Funato Hiromasa、Hoshino Mikio
    • Journal Title

      Cell Reports

      Volume: 24 Issue: 1 Pages: 79-94

    • DOI

      10.1016/j.celrep.2018.06.010

    • NAID

      120006491717

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Glycoprotein nmb is exposed on the surface of dormant breast cancer cells and induces stem cell-like properties2018

    • Author(s)
      Chen Chen、Okita Yukari、Watanabe Yukihide、Abe Fumie、Fikry Muhammad Ali、Ichikawa Yumu、Suzuki Hiroyuki、Shibuya Akira、Kato Mitsuyasu
    • Journal Title

      Cancer Research

      Volume: 78 Issue: 22 Pages: 6424-6435

    • DOI

      10.1158/0008-5472.can-18-0599

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Selective DNAM-1 expression on small peritoneal macrophages contributes to CD4+ T cell costimulation2018

    • Author(s)
      Takenaka Eri、Van Vo Anh、Yamashita-Kanemaru Yumi、Shibuya Akira、Shibuya Kazuko
    • Journal Title

      Scientific Reports

      Volume: 8 Issue: 1 Pages: 15180-15180

    • DOI

      10.1038/s41598-018-33437-4

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Cutting Edge: Identification of Marginal Reticular Cells as Phagocytes of Apoptotic B Cells in Germinal Centers2018

    • Author(s)
      Sato Kazuki、Honda Shin-ichiro、Shibuya Akira、Shibuya Kazuko
    • Journal Title

      The Journal of Immunology

      Volume: 200 Issue: 11 Pages: 3691-3696

    • DOI

      10.4049/jimmunol.1701293

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] TX99 Is a Neutralizing Monoclonal Antibody Against Mouse TIGIT2018

    • Author(s)
      Nakamura Yuho , Naito Keisuke , Yamashita-Kanemaru Yumi , Komori Daisuke , Hirochika Rei , Shibuya Akira , and Shibuya Kazuko
    • Journal Title

      Monoclonal Antibodies in Immunodiagnosis and Immunotherapy

      Volume: 印刷中 Issue: 2 Pages: 105-109

    • DOI

      10.1089/mab.2018.0001

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Serum selenoprotein P, but not selenium, predicts future hyperglycemia in a general Japanese population.2018

    • Author(s)
      Oo SM, Misu H, Saito Y, Tanaka M, Kato S, Kita Y, Takayama H, Takeshita Y, Kanamori T, Nagano T, Nakagen M, Urabe T, Matsuyama N, Kaneko S, Takamura T.
    • Journal Title

      Sci Rep.

      Volume: 8 Issue: 1 Pages: 16727-16727

    • DOI

      10.1038/s41598-018-35067-2

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Inhibin betaE (INHBE) is a possible insulin resistance-associated hepatokine identified by comprehensive gene expression analysis in human liver biopsy samples2018

    • Author(s)
      M. Sugiyama, A. Kikuchi, H. Misu, H. Igawa, M. Ashihara, Y. Kushima, K. Honda, Y. Suzuki, Y. Kawabe, S. Kaneko and T. Takamura
    • Journal Title

      PLoS One

      Volume: 13 Issue: 3 Pages: e0194798-e0194798

    • DOI

      10.1371/journal.pone.0194798

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Endogenous Selenoprotein P, a Liver-Derived Secretory Protein, Mediates Myocardial Ischemia/Reperfusion Injury in Mice.2018

    • Author(s)
      Chikata A, Kato T, Usuda K, Fujita S, Maruyama M, Nagata Y, Sakagami S, Kanamori N, Yaegashi T, Saeki T, Kusayama T, Usui S, Furusho H, Kaneko S, Takamura M.
    • Journal Title

      Int J Mol Sci.

      Volume: 19 Issue: 3 Pages: 878-878

    • DOI

      10.3390/ijms19030878

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Light alcohol consumption has the potential to suppress hepatocellular injury and liver fibrosis in non-alcoholic fatty liver disease.2018

    • Author(s)
      K Yamada, E Mizukoshi, T Seike, R Horii, M Kitahara, H Sunagozaka, K Arai, T Yamashita, M Honda, S Kaneko.
    • Journal Title

      PLoS One

      Volume: 13 Issue: 1 Pages: e0191026-e0191026

    • DOI

      10.1371/journal.pone.0191026

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Sirt2 facilitates hepatic glucose uptake by deacetylating glucokinase regulatory protein2018

    • Author(s)
      Watanabe Hitoshi、Inaba Yuka、Kimura Kumi、Matsumoto Michihiro、Kaneko Shuichi、Kasuga Masato、Inoue Hiroshi
    • Journal Title

      Nat Commun.

      Volume: 9 Issue: 1 Pages: 30-30

    • DOI

      10.1038/s41467-017-02537-6

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Asymmetric Integration of Single-Cell Transcriptomic Data using Latent Dirichlet Allocation and Procrustes Analysis2018

    • Author(s)
      Eto Mitsuhiro、Hirota Wataru、Seno Shigeto、Matsuda Hideo
    • Journal Title

      IEEE International Conference on Bioinformatics and Biomedicin

      Volume: - Pages: 2129-2135

    • DOI

      10.1109/bibm.2018.8621115

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Regnase-1 controls colon epithelial regeneration via regulation of mTOR and purine metabolism2018

    • Author(s)
      Nagahama, Y. Shimoda, M. Mao, G. Singh, S. K. Kozakai, Y. Sun, X. Motooka, D. Nakamura, S. Tanaka, H. Satoh, T. Maeda, K. Akira, S.
    • Journal Title

      Proc Natl Acad Sci U S A

      Volume: 115 Issue: 43 Pages: 11036-11041

    • DOI

      10.1073/pnas.1809575115

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Infection with flaviviruses requires BCLXL for cell survival.2018

    • Author(s)
      Suzuki T, Okamoto T, Katoh H, Sugiyama Y, Kusakabe S, Tokunaga M, Hirano J, Miyata Y, Fukuhara T, Ikawa M, Satoh T, Yoshio S, Suzuki R, Saijo M, Huang DCS, Kanto T, Akira S Matsuura Y
    • Journal Title

      PLoS Pathog

      Volume: 14 Issue: 9 Pages: e1007299-e1007299

    • DOI

      10.1371/journal.ppat.1007299

    • NAID

      120006957426

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Electrophilic properties of itaconate and derivatives regulate the?IκBζ?ATF3 inflammatory axis2018

    • Author(s)
      Bambouskova M, Gorvel L, Lampropoulou V, Sergushichev A, Loginicheva E, Johnson K, Korenfeld D, Mathyer ME, Kim H, Huang LH, Duncan D, Bregman H, Keskin A, Santeford A, Apte RS, Sehgal R, Johnson B, Amarasinghe GK, Soares MP, Satoh T.
    • Journal Title

      Nature

      Volume: 556 Issue: 7702 Pages: 501-504

    • DOI

      10.1038/s41586-018-0052-z

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] BATF2 activates DUSP2 gene expression and up-regulates NF-κB activity via phospho-STAT3 dephosphorylation2018

    • Author(s)
      Hisashi Kanemaru, Fumihiro Yamane, Hiroki Tanaka, Kazuhiko Maeda, Takashi Satoh, Shizuo Akira
    • Journal Title

      International immunology

      Volume: dxy023 Issue: 6 Pages: 255-265

    • DOI

      10.1093/intimm/dxy023

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Sulindac sulfone inhibits the mTORC1 pathway in colon cancer cells by directly targeting voltage-dependent anion channel 1 and 22018

    • Author(s)
      Aono Yuichi、Horinaka Mano、Iizumi Yosuke、Watanabe Motoki、Taniguchi Tomoyuki、Yasuda Shusuke、Sakai Toshiyuki
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 505 Issue: 4 Pages: 1203-1210

    • DOI

      10.1016/j.bbrc.2018.10.050

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mevalonate pathway blockage enhances the efficacy of mTOR inhibitors with the activation of retinoblastoma protein in renal cell carcinoma2018

    • Author(s)
      Hagiwara Nobuhisa、Watanabe Motoki、Iizuka-Ohashi Mahiro、Yokota Isao、Toriyama Seijiro、Sukeno Mamiko、Tomosugi Mitsuhiro、Sowa Yoshihiro、Hongo Fumiya、Mikami Kazuya、Soh Jintetsu、Fujito Akira、Miyashita Hiroaki、Morioka Yukako、Miki Tsuneharu、Ukimura Osamu、Sakai Toshiyuki
    • Journal Title

      Cancer Letters

      Volume: 431 Pages: 182-189

    • DOI

      10.1016/j.canlet.2018.05.025

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Blockage of the mevalonate pathway overcomes the apoptotic resistance to MEK inhibitors with suppressing the activation of Akt in cancer cells.2018

    • Author(s)
      Iizuka-Ohashi M1,2, Watanabe M1, Sukeno M1, Morita M1, Hoang NTH3, Kuchimaru T, Kizaka-Kondoh S, Sowa Y1 Sakaguchi K, Taguchi T, Sakai T.
    • Journal Title

      Oncotarget.

      Volume: 9 Issue: 28 Pages: 19597-19612

    • DOI

      10.18632/oncotarget.24696

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Reinforce the antitumor activity of CD8+ T cells via glutamine restriction2018

    • Author(s)
      Nabe Shogo、Yamada Takeshi、Suzuki Junpei、Toriyama Koji、Yasuoka Toshiaki、Kuwahara Makoto、Shiraishi Atsushi、Takenaka Katsuto、Yasukawa Masaki、Yamashita Masakatsu
    • Journal Title

      Cancer Science

      Volume: 109 Issue: 12 Pages: 3737-3750

    • DOI

      10.1111/cas.13827

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The tumor suppressor menin prevents effector CD8 T-cell dysfunction by targeting mTORC1-dependent metabolic activation2018

    • Author(s)
      Suzuki Junpei、Yamada Takeshi、Inoue Kazuki、Nabe Shogo、Kuwahara Makoto、Takemori Nobuaki、Takemori Ayako、Matsuda Seiji、Kanoh Makoto、Imai Yuuki、Yasukawa Masaki、Yamashita Masakatsu
    • Journal Title

      Nature Communications

      Volume: 9 Issue: 1 Pages: 1-12

    • DOI

      10.1038/s41467-018-05854-6

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Three-step transcriptional priming that drives the commitment of multipotent progenitors toward B cells2018

    • Author(s)
      Miyai Tomohiro、Takano Junichiro、Endo Takaho A.、Kawakami Eiryo、Agata Yasutoshi、Motomura Yasutaka、Kubo Masato、Kashima Yukie、Suzuki Yutaka、Kawamoto Hiroshi、Ikawa Tomokatsu
    • Journal Title

      Genes & Development

      Volume: 32 Issue: 2 Pages: 112-126

    • DOI

      10.1101/gad.309575.117

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] GITR cosignal in ILC2s controls allergic lung inflammation.2018

    • Author(s)
      Nagashima H, Okuyama Y, Fujita T, Takeda T, Motomura Y, Moro K, Hidaka T, Omori K, Sakurai T, Machiyama T, Ndhlovu LC, Riccardi C, So T, Ishii N.
    • Journal Title

      J Allergy Clin Immunol.

      Volume: - Issue: 5 Pages: 1939-1943.e8

    • DOI

      10.1016/j.jaci.2018.01.028

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Proteomics analysis identified peroxiredoxin 2 involved in early-phase left ventricular impairment in hamsters with cardiomyopathy.2018

    • Author(s)
      Kuzuya K, Ichihara S, Suzuki Y, Inoue C, Ichihara G, Kurimoto S, Oikawa S.
    • Journal Title

      PLoS One.

      Volume: 13 Issue: 2 Pages: e0192624-e0192624

    • DOI

      10.1371/journal.pone.0192624

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] The DNA methylation profile of liver tumors in C3H mice and identification of differentially methylated regions involved in the regulation of tumorigenic genes.2018

    • Author(s)
      Matsushita J, Okamura K, Nakabayashi K, Suzuki T, Horibe Y, Kawai T, Sakurai T, Yamashita S, Higami Y, Ichihara G, Hata K, Nohara K
    • Journal Title

      BMC Cancer

      Volume: 18 Issue: 1 Pages: 317-317

    • DOI

      10.1186/s12885-018-4221-0

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Pulmonary hypofunction due to calcium carbonate nanomaterial exposure in occupational workers: a cross-sectional study2018

    • Author(s)
      Li Guoliang、Liang Lihong、Yang Jingchao、Zeng Lihai、Xie Zhiwei、Zhong Yizhou、Ruan Xiaolin、Dong Ming、Yang Zhanhong、Lai Guanchao、Huang Weixin、Yang Aichu、Chen Jiabing、Wu Banghua、Xu Huaming、Meng Dezhi、Hu Shijie、Xia Lihua、Yang Xingfen、Li Laiyu、Ichihara Sahoko、Ichihara Gaku、Huang Hanlin、Huang Zhenlie
    • Journal Title

      Nanotoxicology

      Volume: 12 Issue: 6 Pages: 571-585

    • DOI

      10.1080/17435390.2018.1465606

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Exposure to 1,2-Dichloropropane Upregulates the Expression of Activation-Induced Cytidine Deaminase (AID) in Human Cholangiocytes Co-Cultured With Macrophages2018

    • Author(s)
      Zong Cai、Kimura Yusuke、Kinoshita Kazuo、Takasu Shigetada、Zhang Xiao、Sakurai Toshihiro、Sekido Yoshitaka、Ichihara Sahoko、Endo Ginji、Ichihara Gaku
    • Journal Title

      Toxicological Sciences

      Volume: 168 Issue: 1 Pages: 137-148

    • DOI

      10.1093/toxsci/kfy280

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Carcinogenicity of isobutyl nitrite, β-picoline, and some acrylates2018

    • Author(s)
      Kromhout H, Friesen M, Marques MM, Sergi CM, Abdallah M, Benke G, Cesta M, Germolec D, Houck K, Ichihara G, Jameson CW, Kanno J, Pogribny I, Svendsen C, Benbrahim-Tallaa L, Guyton KZ, Grosse Y, El Ghissassi F, Bouvard V, Hall A.
    • Journal Title

      The Lancet Oncology

      Volume: 19 Issue: 8 Pages: 1020-1022

    • DOI

      10.1016/s1470-2045(18)30491-1

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Familial episodic limb pain in kindreds with novel Nav1.9 mutations2018

    • Author(s)
      Kabata R, Okuda H, Noguchi A, Kondo D, Fujiwara M, Hata K, Kato Y, Ishikawa K, Tanaka M, Sekine Y, Hishikawa N, Mizukami T, Ito J, Akasaka M, Sakurai K, Yoshida T, Minoura H, Hayashi T, Inoshita K, Matsuyama M, Kinjo N, Cao Y, Inoue S, Kobayashi H, Harada KH, Youssefian S, Takahashi T, Koizumi A.
    • Journal Title

      PLOS ONE

      Volume: 13 Issue: 12 Pages: e0208516-e0208516

    • DOI

      10.1371/journal.pone.0208516

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] EXPRESS: Rare variants in RNF213, a susceptibility gene for moyamoya disease, are found in patients with pulmonary hypertension and aggravate hypoxia-induced pulmonary hypertension in mice2018

    • Author(s)
      Kobayashi Hatasu、Kabata Risako、Kinoshita Hideyuki、Morimoto Takaaki、Ono Koh、Takeda Midori、Choi Jungmi、Okuda Hiroko、Liu Wanyang、Harada Kouji H、Kimura Takeshi、Youssefian Shohab、Koizumi Akio
    • Journal Title

      Pulmonary Circulation

      Volume: - Issue: 3 Pages: 204589401877815-204589401877815

    • DOI

      10.1177/2045894018778155

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Dysregulation of RNF213 promotes cerebral hypoperfusion2018

    • Author(s)
      Morimoto T, Enmi J, Hattori Y, Iguchi S, Saito S, Harada K, Okuda H, Mineharu Y, Takagi Y, Youssefian S, Iida H, Miyamoto S, Ihara M, Kobayashi H, Koizumi A.
    • Journal Title

      Sci Rep

      Volume: 8 Issue: 1 Pages: 3607-3607

    • DOI

      10.1038/s41598-018-22064-8

    • NAID

      120006510289

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] β-cell-specific overexpression of adiponectin receptor 1 does not improve diabetes mellitus in Akita mice.2018

    • Author(s)
      Choi J, Kobayashi H, Okuda H, Harada KH, Takeda M, Fujimoto H, Yamane S, Tanaka D, Youssefian S, Inagaki N, Koizumi A.
    • Journal Title

      PLoS One

      Volume: 13 (1) Issue: 1 Pages: e0190863-e0190863

    • DOI

      10.1371/journal.pone.0190863

    • NAID

      120006459971

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Protein residue networks from energetic and geometric data ? are they identical?2018

    • Author(s)
      Vladimir Sladek, Hiroaki Tokiwa, Hitoshi Shimano, Yasuteru Shigeta
    • Journal Title

      J. Chem. Theor. Comp.

      Volume: 14(12) Issue: 12 Pages: 6623-6631

    • DOI

      10.1021/acs.jctc.8b00733

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Network meta-analysis of the relative efficacy of bariatric surgeries for diabetes remission2018

    • Author(s)
      Kodama S.、Fujihara K.、Horikawa C.、Harada M.、Ishiguro H.、Kaneko M.、Furukawa K.、Matsubayashi Y.、Matsunaga S.、Shimano H.、Tanaka S.、Kato K.、Sone H.
    • Journal Title

      Obesity Reviews

      Volume: 19 Issue: 12 Pages: 1621-1629

    • DOI

      10.1111/obr.12751

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Relationship between intake of fruit separately from vegetables and triglycerides - A meta-analysis2018

    • Author(s)
      Kodama S, Horikawa C, Fujihara K, Ishii D, Hatta M, Takeda Y, Kitazawa M, Matsubayashi Y, Shimano H, Kato K, Tanaka S, Sone H
    • Journal Title

      Clin Nutr ESPEN

      Volume: 27 Pages: 53-8

    • DOI

      10.1016/j.clnesp.2018.07.001

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The Peroxisome Proliferator-Activated Receptor α (PPARα) Agonist Pemafibrate Protects against Diet-Induced Obesity in Mice2018

    • Author(s)
      Araki Masaya、Nakagawa Yoshimi、Oishi Asayo、Han Song-iee、Wang Yunong、Kumagai Kae、Ohno Hiroshi、Mizunoe Yuhei、Iwasaki Hitoshi、Sekiya Motohiro、Matsuzaka Takashi、Shimano Hitoshi
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 19 Issue: 7 Pages: 2148-2148

    • DOI

      10.3390/ijms19072148

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Brg1 regulates pro-lipogenic transcription by modulating SREBP activity in hepatocytes2018

    • Author(s)
      Li Nan、Li Min、Hong Wenxuan、Shao Jing、Xu Huihui、Shimano Hitoshi、Lu Jun、Xu Yong
    • Journal Title

      Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease

      Volume: 1864 Issue: 9 Pages: 2881-2889

    • DOI

      10.1016/j.bbadis.2018.05.022

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Malondialdehyde-modified LDL-related variables are associated with diabetic kidney disease in type 2 diabetes2018

    • Author(s)
      Furukawa Shoko、Suzuki Hiroaki、Fujihara Kazuya、Kobayashi Kazuto、Iwasaki Hitoshi、Sugano Yoko、Yatoh Shigeru、Sekiya Motohiro、Yahagi Naoya、Shimano Hitoshi
    • Journal Title

      Diabetes Research and Clinical Practice

      Volume: 141 Pages: 237-243

    • DOI

      10.1016/j.diabres.2018.05.019

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] CREBH Regulates Systemic Glucose and Lipid Metabolism2018

    • Author(s)
      Nakagawa Yoshimi、Shimano Hitoshi
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 19 Issue: 5 Pages: 1396-1396

    • DOI

      10.3390/ijms19051396

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Evaluation of safety for hepatectomy in a novel mouse model with nonalcoholic-steatohepatitis2018

    • Author(s)
      Ozawa Yusuke、Tamura Takafumi、Owada Yohei、Shimizu Yoshio、Kemmochi Akira、Hisakura Katsuji、Matsuzaka Takashi、Shimano Hitoshi、Isoda Hiroko、Ohkohchi Nobuhiro
    • Journal Title

      World Journal of Gastroenterology

      Volume: 24 Issue: 15 Pages: 1622-1631

    • DOI

      10.3748/wjg.v24.i15.1622

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Transgenic Mice Overexpressing SREBP-1a in Male ob/ob Mice Exhibit Lipodystrophy and Exacerbate Insulin Resistance.2018

    • Author(s)
      Ohno H, Matsuzaka T, Tang N, Sharma R, Motomura K, Shimura T, Satoh A, Han SI, Takeuchi Y, Aita Y, Iwasaki H, Yatoh S, Suzuki H, Sekiya M, Nakagawa Y, Sone H, Yahagi N, Yamada N, Higami Y, Shimano H.
    • Journal Title

      Endocrinology.

      Volume: 159(6) Issue: 6 Pages: 2308-2323

    • DOI

      10.1210/en.2017-03179

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Molecular association model of PPARα and its new specific and efficient ligand, pemafibrate: Structural basis for SPPARMα2018

    • Author(s)
      Yamamoto Yuta、Takei Kenta、Arulmozhiraja Sundaram、Sladek Vladimir、Matsuo Naoya、Han Song-iee、Matsuzaka Takashi、Sekiya Motohiro、Tokiwa Takaki、Shoji Mitsuo、Shigeta Yasuteru、Nakagawa Yoshimi、Tokiwa Hiroaki、Shimano Hitoshi
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 499 Issue: 2 Pages: 239-245

    • DOI

      10.1016/j.bbrc.2018.03.135

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Saturated Fatty Acids Undergo Intracellular Crystallization and Activate the NLRP3 Inflammasome in MacrophagesHighlights2018

    • Author(s)
      Karasawa Tadayoshi、Kawashima Akira、Usui-Kawanishi Fumitake、Watanabe Sachiko、Kimura Hiroaki、Kamata Ryo、Shirasuna Koumei、Koyama Yutaro、Sato-Tomita Ayana、Matsuzaka Takashi、Tomoda Hiroshi、Park Sam-Yong、Shibayama Naoya、Shimano Hitoshi、Kasahara Tadashi、Takahashi Masafumi
    • Journal Title

      Arteriosclerosis, Thrombosis, and Vascular Biology

      Volume: 38 Issue: 4 Pages: 744-756

    • DOI

      10.1161/atvbaha.117.310581

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Epigenetic modulation of Fgf21 in the perinatal mouse liver ameliorates diet-induced obesity in adulthood2018

    • Author(s)
      X Yuan, K Tsujimoto, K Hashimoto, K Kawahori, N Hanzawa, M Hamaguchi, T Seki, M Nawa, T Ehara, Y Kitamura, I Hatada, M Konishi, N Itoh, Y Nakagawa, H Shimano, T Takai-Igarashi, Y Kamei, Y Ogawa.
    • Journal Title

      Nature Communications

      Volume: 9 Issue: 1 Pages: 636-636

    • DOI

      10.1038/s41467-018-03038-w

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Age-dependent changes in dynamic standing-balance ability evaluated quantitatively using a stabilometer2018

    • Author(s)
      Suzuki Yasuhiro、Yatoh Shigeru、Suzuki Hiroaki、Tanabe Yuuki、Shimizu Yukiyo、Hada Yasushi、Shimano Hitoshi
    • Journal Title

      Journal of Physical Therapy Science

      Volume: 30 Issue: 1 Pages: 86-91

    • DOI

      10.1589/jpts.30.86

    • NAID

      130006321186

    • ISSN
      0915-5287, 2187-5626
    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A candidate functional SNP rs7074440 in TCF7L2 alters gene expression through C-FOS in hepatocytes.2018

    • Author(s)
      Piao X, Yahagi N, Takeuchi Y, Aita Y, Murayama Y, Sawada Y, Shikama A, Masuda Y, Nishi-Tatsumi M, Kubota M, Izumida Y, Sekiya M, Matsuzaka T, Nakagawa Y, Sugano Y, Iwasaki H, Kobayashi K, Yatoh S, Suzuki H, Yagyu H, Kawakami Y, Shimano H.
    • Journal Title

      FEBS Lett.

      Volume: 592(3) Issue: 3 Pages: 422-433

    • DOI

      10.1002/1873-3468.12975

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] A Rare Coexistence of Pheochromocytoma and Parkinson&apos;s Disease With Diagnostic Challenges2018

    • Author(s)
      Matsumura-Matsuda Erika、Sekiya Motohiro、Omoto-Inuzuka Miyoko、Santo Kana、Shikama Akito、Kuba Motoko、Sugano Yoko、Iwasaki Hitoshi、Yatoh Shigeru、Sato Taiki、Hara Hisato、Takekoshi Kazuhiro、Suzuki Hiroaki、Shimano Hitoshi
    • Journal Title

      Internal Medicine

      Volume: 57 Issue: 7 Pages: 979-985

    • DOI

      10.2169/internalmedicine.9242-17

    • NAID

      130006602591

    • ISSN
      0918-2918, 1349-7235
    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Relationships among cardiorespiratory fitness, muscular fitness, and cardiometabolic risk factors in Japanese adolescents: Niigata screening for and preventing the development of non-communicable disease study-Agano (NICE EVIDENCE Study-Agano) 2.2018

    • Author(s)
      Morikawa SY, Fujihara K, Hatta M, Osawa T, Ishizawa M, Yamamoto M, Furukawa K, Ishiguro H, Matsunaga S, Ogawa Y, Shimano H, Sone H.
    • Journal Title

      Pediatr Diabetes.

      Volume: 印刷中 Issue: 4 Pages: 593-602

    • DOI

      10.1111/pedi.12623

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Monopoiesis in humans and mice2018

    • Author(s)
      Kawamura Shunsuke、Ohteki Toshiaki
    • Journal Title

      International Immunology

      Volume: 30 Issue: 11 Pages: 503-509

    • DOI

      10.1093/intimm/dxy063

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Macrophages in inflammation, repair and regeneration2018

    • Author(s)
      Oishi Y, Manabe I
    • Journal Title

      Int Immunol

      Volume: 30 Issue: 11 Pages: 511-528

    • DOI

      10.1093/intimm/dxy054

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Does the prenatal bisphenol A exposure alter DNA methylation levels in the mouse hippocampus?: An analysis using a high-sensitivity methylome technique2018

    • Author(s)
      Aiba Toshiki、Saito Toshiyuki、Hayashi Akiko、Sato Shinji、Yunokawa Harunobu、Maruyama Toru、Fujibuchi Wataru、Ohsako Seiichiroh
    • Journal Title

      Genes and Environment

      Volume: 40 Issue: 1 Pages: 12-12

    • DOI

      10.1186/s41021-018-0099-y

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Detection of dioxin-induced demethylation of mouse Cyp1a1 gene promoter by a new labeling method for short DNA fragments possessing 5'-methylcytosine at the end2018

    • Author(s)
      Kurita Hisaka、Aiba Toshiki、Saito Toshiyuki、Ohsako Seiichiroh
    • Journal Title

      Genes and Environment

      Volume: 40 Issue: 1 Pages: 1-1

    • DOI

      10.1186/s41021-017-0089-5

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Expression of xenobiotic biomarkers CYP1 family in preputial tissue of patients with hypospadias and phimosis and its association with DNA methylation level of SRD5A2 minimal promoter.2018

    • Author(s)
      Ohsako S, Aiba T, Miyado M, Fukami M, Ogata T, Hayashi Y, Mizuno K and Kojima Y.
    • Journal Title

      Arch Environ Contam Toxicol.

      Volume: 74 Issue: 2 Pages: 240-247

    • DOI

      10.1007/s00244-017-0466-x

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Lung fibroblasts express a miR-19a-19b-20a sub-cluster to suppress TGF-β-associated fibroblast activation in murine pulmonary fibrosis2018

    • Author(s)
      Souma Kunihiko、Shichino Shigeyuki、Hashimoto Shinichi、Ueha Satoshi、Tsukui Tatsuya、Nakajima Takuya、Suzuki Hiroshi I.、Shand Francis H. W.、Inagaki Yutaka、Nagase Takahide、Matsushima Kouji
    • Journal Title

      Scientific Reports

      Volume: 8 Issue: 1 Pages: 16642-16642

    • DOI

      10.1038/s41598-018-34839-0

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] STAM-binding protein regulates melanoma metastasis through SLUG stabilization.2018

    • Author(s)
      Iwakami Y, Yokoyama S, Watanabe K, Hayakawa Y.
    • Journal Title

      Biochem Biophys Res Commun.

      Volume: 507 Issue: 1-4 Pages: 484-488

    • DOI

      10.1016/j.bbrc.2018.11.068

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Lung-resident natural killer cells control pulmonary tumor growth in mice2018

    • Author(s)
      Yamamoto Yutaka、Miyazato Kiho、Takahashi Kei、Yoshimura Naoki、Tahara Hideaki、Hayakawa Yoshihiro
    • Journal Title

      Cancer Science

      Volume: 109 Issue: 9 Pages: 2670-2676

    • DOI

      10.1111/cas.13703

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A Gata3 3′ Distal Otic Vesicle Enhancer Directs Inner Ear-Specific Gata3 Expression2018

    • Author(s)
      Moriguchi Takashi、Hoshino Tomofumi、Rao Arvind、Yu Lei、Takai Jun、Uemura Satoshi、Ise Kazue、Nakamura Yasuhiro、Lim Kim-Chew、Shimizu Ritsuko、Yamamoto Masayuki、Engel James Douglas
    • Journal Title

      Molecular and Cellular Biology

      Volume: 38 Issue: 21 Pages: 21-21

    • DOI

      10.1128/mcb.00302-18

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Satellite RNA Increases DNA Damage and Accelerates Tumor Formation in Mouse Models of Pancreatic Cancer2018

    • Author(s)
      Kishikawa Takahiro、Otsuka Motoyuki、Suzuki Tatsunori、Seimiya Takahiro、Sekiba Kazuma、Ishibashi Rei、Tanaka Eri、Ohno Motoko、Yamagami Mari、Koike Kazuhiko
    • Journal Title

      Molecular Cancer Research

      Volume: 16 Issue: 8 Pages: 1255-1262

    • DOI

      10.1158/1541-7786.mcr-18-0139

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] MicroRNA-7: a potent suppressor of the malignant potential of hepatocellular carcinoma2018

    • Author(s)
      Otsuka Motoyuki、Tanaka Eri、Sekiba Kazuma、Seimiya Takahiro、Yamagami Mari、Koike Kazuhiko
    • Journal Title

      Non-coding RNA Investigation

      Volume: 2 Pages: 30-30

    • DOI

      10.21037/ncri.2018.05.04

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hepatitis B virus pathogenesis: Fresh insights into hepatitis B virus RNA2018

    • Author(s)
      Sekiba Kazuma、Otsuka Motoyuki、Ohno Motoko、Yamagami Mari、Kishikawa Takahiro、Suzuki Tatsunori、Ishibashi Rei、Seimiya Takahiro、Tanaka Eri、Koike Kazuhiko
    • Journal Title

      World Journal of Gastroenterology

      Volume: 24 Issue: 21 Pages: 2261-2268

    • DOI

      10.3748/wjg.v24.i21.2261

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] DHX9 regulates production of hepatitis B virus-derived circular RNA and viral protein levels2018

    • Author(s)
      Sekiba Kazuma、Otsuka Motoyuki、Ohno Motoko、Kishikawa Takahiro、Yamagami Mari、Suzuki Tatsunori、Ishibashi Rei、Seimiya Takahiro、Tanaka Eri、Koike Kazuhiko
    • Journal Title

      Oncotarget

      Volume: 9 Issue: 30 Pages: 20953-20964

    • DOI

      10.18632/oncotarget.25104

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Suppression of IL-17F, but not of IL-17A, provides protection against colitis by inducing T(reg) cells through modification of the intestinal microbiota.2018

    • Author(s)
      Tang C, Kakuta S, Shimizu K, Kadoki M, Kamiya T, Shimazu T, Kubo S, Saijo S, Ishigame H, Nakae S, Iwakura Y.
    • Journal Title

      Nat Immunol.

      Volume: 19 Issue: 7 Pages: 755-765

    • DOI

      10.1038/s41590-018-0134-y

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Effects of high fructose intake on liver injury progression in high fat diet induced fatty liver disease in ovariectomized female mice2018

    • Author(s)
      Ohashi Tomoko、Kato Masaki、Yamasaki Akihiro、Kuwano Akifumi、Suzuki Hideo、Kohjima Motoyuki、Ogawa Yoshihiro
    • Journal Title

      Food and Chemical Toxicology

      Volume: 118 Pages: 190-197

    • DOI

      10.1016/j.fct.2018.05.006

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Obeticholic acid protects against hepatocyte death and liver fibrosis in a murine model of nonalcoholic steatohepatitis.2018

    • Author(s)
      T. Goto, M. Itoh, T. Suganami, S. Kanai, I. Shirakawa, T. Sakai, M. Asakawa,T. Yoneyama, T. Kai, Y. Ogawa.
    • Journal Title

      Sci. Rep.

      Volume: 8 Issue: 1 Pages: 8157-8157

    • DOI

      10.1038/s41598-018-26383-8

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Efficient identification of compounds suppressing protein precipitation via solvent screening using serial deletion mutants of the target protein2018

    • Author(s)
      Yunoki Kaori、Yoshinaga Sosuke、Takeda Mitsuhiro、Nagano Ryohei、Tsuchiya Yusuke、Sonoda Akihiro、Tsuji Tatsuichiro、Hirakane Makoto、Toda Etsuko、Terashima Yuya、Matsushima Kouji、Terasawa Hiroaki
    • Journal Title

      Genes to Cells

      Volume: 23 Issue: 2 Pages: 70-79

    • DOI

      10.1111/gtc.12554

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Single blood transfusion induces the production of donor-specific alloantibodies and regulatory T cells mainly in the spleen.2018

    • Author(s)
      Ueta H, Kitazawa Y, Sawanobori Y, Ueno T, Ueha S, Matsushima K, Matsuno K.
    • Journal Title

      Int Immunol

      Volume: 30 Issue: 2 Pages: 53-67

    • DOI

      10.1093/intimm/dxx078

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Increased diversity with reduced "diversity evenness" of tumor infiltrating T-cells for the successful cancer immunotherapy.2018

    • Author(s)
      Hosoi A, Takeda K, Nagaoka K, Iino T, Matsushita H, Ueha S, Aoki S, Matsushima K, Kubo M, Morikawa T, Kitaura K, Suzuki R, Kakimi K.
    • Journal Title

      Sci Rep

      Volume: 8 Issue: 1 Pages: 1058-1058

    • DOI

      10.1038/s41598-018-19548-y

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] NK Cells Control Tumor-Promoting Function of Neutrophils in Mice2018

    • Author(s)
      Ogura K, Sato-Matsushita M, Yamamoto S, Hori T, Sasahara M, Iwakura Y, Saiki I, Tahara H, Hayakawa Y
    • Journal Title

      Cancer Immunol Res

      Volume: 印刷中 Issue: 3 Pages: 348-357

    • DOI

      10.1158/2326-6066.cir-17-0204

    • NAID

      120006402039

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Single blood transfusion induces the production of donor-specific alloantibodies and regulatory T cells mainly in the spleen.2018

    • Author(s)
      Ueta H, Kitazawa Y, Sawanobori Y, Ueno T, Ueha S, Matsushima K, Matsuno K.
    • Journal Title

      Int Immunol

      Volume: 8 Pages: 53-67

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Dysregulation of RNF213 promotes cerebral hypoperfusion.2018

    • Author(s)
      Morimoto T, Enmi JI, Hattori Y, Iguchi S, Saito S, Harada KH, Okuda H, Mineharu Y, Takagi Y, Youssefian S, Iida H, Miyamoto S, Ihara M, Kobayashi H, Koizumi A.
    • Journal Title

      Sci Rep

      Volume: 26 Pages: 3607-3607

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Correction to Synthesis of Potent and Selective Inhibitors of Aldo-Keto Reductase 1B10 and Their Efficacy against Proliferation, Metastasis, and Cisplatin Resistance of Lung Cancer Cells.2018

    • Author(s)
      Endo S, Xia S, Suyama M, Morikawa Y, Oguri H, Hu D, Ao Y, Takahara S, Horino Y, Hayakawa Y, Watanabe Y, Gouda H, Hara A, Kuwata K, Toyooka N, Matsunaga T, Ikari A.
    • Journal Title

      J Med Chem

      Volume: 8 Pages: 1380-1380

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Expression of Xenobiotic Biomarkers CYP1 Family in Preputial Tissue of Patients with Hypospadias and Phimosis and Its Association with DNA Methylation Level of SRD5A2 Minimal Promoter.2018

    • Author(s)
      Ohsako S, Aiba T, Miyado M, Fukami M, Ogata T, Hayashi Y, Mizuno K, Kojima Y.
    • Journal Title

      Arch Environ Contam Toxicol

      Volume: 74(2) Pages: 240-247

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Efficient identification of compounds suppressing protein precipitation via solvent screening using serial deletion mutants of the target protein.2018

    • Author(s)
      Yunoki K, Yoshinaga S, Takeda M, Nagano R, Tsuchiya Y, Sonoda A, Tsuji T, Hirakane M, Toda E, Terashima Y, Matsushima K, Terasawa H.
    • Journal Title

      Genes Cells

      Volume: 23(2) Pages: 70-79

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] NK Cells Control Tumor-Promoting Function of Neutrophils in Mice.2018

    • Author(s)
      Ogura K, Sato-Matsushita M, Yamamoto S, Hori T, Sasahara M, Iwakura Y, Saiki I, Tahara H, Hayakawa Y.
    • Journal Title

      Cancer Immunol Res

      Volume: 23

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Increased diversity with reduced "diversity evenness" of tumor infiltrating T-cells for the successful cancer immunotherapy.2018

    • Author(s)
      Hosoi A, Takeda K, Nagaoka K, Iino T, Matsushita H, Ueha S, Aoki S, Matsushima K, Kubo M, Morikawa T, Kitaura K, Suzuki R, Kakimi K.
    • Journal Title

      Sci Rep

      Volume: 18 Pages: 1058-1058

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] IFN-γ-dependent epigenetic regulation instructs colitogenic monocyte/macrophage lineage differentiation in vivo.2017

    • Author(s)
      Nakanishi Y, Sato T, Takahashi K, Ohteki T.
    • Journal Title

      Mucosal Immunol

      Volume: - Issue: 3 Pages: 871-880

    • DOI

      10.1038/mi.2017.104

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Production of low-molecular weight soluble yeast β-glucans by an acid degradation method.2017

    • Author(s)
      Ishimoto, Y., Ishibashi, K. I., Yamanaka, D., Adachi, Y., Kanzaki, K., Iwakura, Y., and Ohno, N.
    • Journal Title

      Int. J. Biol. Macromol.

      Volume: 107 Issue: 3 Pages: 2269-2278

    • DOI

      10.1038/mi.2017.86

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] The Dark Side of IFN-g: Its Role in Promoting Cancer Immunoevasion.2017

    • Author(s)
      Mojic M, Takeda K, Hayakawa Y.
    • Journal Title

      Int J Mol Sci

      Volume: 28 Issue: 1 Pages: 1-13

    • DOI

      10.3390/ijms19010089

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Long-Lasting Graft-Derived Donor T Cells Contribute to the Pathogenesis of Chronic Graft-versus-Host Disease in Mice.2017

    • Author(s)
      Kosugi-Kanaya M, Ueha S, Abe J, Shichino S, Shand FHW, Morikawa T, Kurachi M, Shono Y, Sudo N, Yamashita A, Suenaga F, Yokoyama A, Yong W, Imamura M, Teshima T, Matsushima K.
    • Journal Title

      Front Immunol

      Volume: 18 Pages: 1-14

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] ASK1 facilitates tumor metastasis through phosphorylation of an ADP receptor P2Y(12) in platelets.2017

    • Author(s)
      Kamiyama M, Shirai T, Tamura S, Suzuki-Inoue K, Ehata S, Takahashi K, Miyazono K, Hayakawa Y, Sato T, Takeda K, Naguro I, Ichijo H.
    • Journal Title

      Cell Death Differ

      Volume: 24(12) Pages: 2066-2076

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The CD45(+) fraction in murine adipose tissue derived stromal cells harbors immune-inhibitory inflammatory cells.2017

    • Author(s)
      Nasti A, Sakai Y, Seki A, Buffa GB, Komura T, Mochida H, Yamato M, Yoshida K, Ho TTB, Takamura M, Usui S, Wada T, Honda M, Kaneko S.
    • Journal Title

      Eur J Immunol

      Volume: 47(12) Pages: 2163-2174

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effect of sodium-glucose cotransporter 2 (SGLT2) inhibition on weight loss is partly mediated by liver-brain-adipose neurocircuitry.2017

    • Author(s)
      Sawada Y, Izumida Y, Takeuchi Y, Aita Y, Wada N, Li E, Murayama Y, Piao X, Shikama A, Masuda Y, Nishi-Tatsumi M, Kubota M, Sekiya M, Matsuzaka T, Nakagawa Y, Sugano Y, Iwasaki H, Kobayashi K, Yatoh S, Suzuki H, Yagyu H, Kawakami Y, et al.
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 4 Pages: 40-45

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Ribosomal protein S3 regulates XIAP expression independently of the NF-ホコB pathway in breast cancer cells.2017

    • Author(s)
      Ono H, Iizumi Y, Goi W, Sowa Y, Taguchi T, Sakai T.
    • Journal Title

      Oncol Rep

      Volume: 38(5) Pages: 3205-3210

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Report of the International Stem Cell Banking Initiative Workshop Activity: Current Hurdles and Progress in Seed-Stock Banking of Human Pluripotent Stem Cells.2017

    • Author(s)
      Kim JH, Kurtz A, Yuan BZ, Zeng F, Lomax G, Loring JF, Crook J, Ju JH, Clarke L, Inamdar MS, Pera M, Firpo MT, Sheldon M, Rahman N, O'Shea O, Pranke P, Zhou Q, Isasi R, Rungsiwiwut R, Kawamata S, Oh S, Ludwig T, et al.
    • Journal Title

      Stem Cells Transl Med

      Volume: 6(11) Pages: 1956-1962

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Comprehensive single-cell transcriptome analysis reveals heterogeneity in endometrioid adenocarcinoma tissues.2017

    • Author(s)
      Hashimoto S, Tabuchi Y, Yurino H, Hirohashi Y, Deshimaru S, Asano T, Mariya T, Oshima K, Takamura Y, Ukita Y, Ametani A, Kondo N, Monma N, Takeda T, Misu S, Okayama T, Ikeo K, Saito T, Kaneko S, Suzuki Y, Hattori M, Matsushima K, et al.
    • Journal Title

      Sci Rep

      Volume: 27 Pages: 14225-14225

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Gene expression profiling of hepatocarcinogenesis in a mouse model of chronic hepatitis B.2017

    • Author(s)
      Nosaka T, Naito T, Hiramatsu K, Ohtani M, Nemoto T, Marusawa H, Ma N, Hiraku Y, Kawanishi S, Yamashita T, Kaneko S, Nakamoto Y.
    • Journal Title

      PLoS One

      Volume: 2

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Combination of anti-CD4 antibody treatment and donor lymphocyte infusion ameliorates graft-versus-host disease while preserving graft-versus-tumor effects in murine allogeneic hematopoietic stem cell transplantation.2017

    • Author(s)
      Ueha S, Yokochi S, Ishiwata Y, Kosugi-Kanaya M, Shono Y, Shibayama S, Ito S, Matsushima K.
    • Journal Title

      Cancer Sci

      Volume: 108(10) Pages: 1967-1973

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Long non-coding RNA HOTAIR promotes cell migration by upregulating insulin growth factor-binding protein 2 in renal cell carcinoma.2017

    • Author(s)
      Katayama H, Tamai K, Shibuya R, Nakamura M, Mochizuki M, Yamaguchi K, Kawamura S, Tochigi T, Sato I, Okanishi T, Sakurai K, Fujibuchi W, Arai Y, Satoh K.
    • Journal Title

      Sci Rep

      Volume: 20 Pages: 12016-12016

    • NAID

      120006364089

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Proteasome Inhibitor-Loaded Micelles Enhance Antitumor Activity Through Macrophage Reprogramming by NF-ホコB Inhibition.2017

    • Author(s)
      Wu H, Tao A, Martin JD, Quader S, Liu X, Takahashi K, Hespel L, Miura Y, Hayakawa Y, Irimura T, Cabral H, Kataoka K.
    • Journal Title

      J Pharm Sci

      Volume: 106(9) Pages: 2438-2446

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Optimized retroviral transduction of mouse T cells for in vivo assessment of gene function.2017

    • Author(s)
      Kurachi M, Kurachi J, Chen Z, Johnson J, Khan O, Bengsch B, Stelekati E, Attanasio J, McLane LM, Tomura M, Ueha S, Wherry EJ.
    • Journal Title

      Nat Protoc

      Volume: 12(9) Pages: 1980-1998

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] RNF213 p.R4810K Variant and Intracranial Arterial Stenosis or Occlusion in Relatives of Patients with Moyamoya Disease.2017

    • Author(s)
      Matsuda Y, Mineharu Y, Kimura M, Takagi Y, Kobayashi H, Hitomi T, Harada KH, Uchihashi Y, Funaki T, Miyamoto S, Koizumi A.
    • Journal Title

      J Stroke Cerebrovasc Dis

      Volume: 26(8) Pages: 1841-1847

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Occupational exposure limits for ethylene glycol monobutyl ether, isoprene, isopropyl acetate and propyleneimine, and classifications on carcinogenicity, occupational sensitizer and reproductive toxicant.2017

    • Author(s)
      Committee for Recommendation of Occupational Exposure Limits, Japan Society for Occupational Health., Azuma K, Endo G, Endo Y, Fukushima T, Hara K, Hori H, Horie S, Horiguchi H, Ichiba M, Ichihara G, Ikeda M, Ishitake T, Ito A, Ito Y, Iwasawa S, Kamijima M, Karita K, Katoh T, Kawai T, Kawamoto T, Kishi R, et al.
    • Journal Title

      J Occup Health

      Volume: 27 Pages: 364-366

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Elovl6 Deficiency Improves Glycemic Control in Diabetic db/db Mice by Expanding ホイ-Cell Mass and Increasing Insulin Secretory Capacity.2017

    • Author(s)
      Zhao H, Matsuzaka T, Nakano Y, Motomura K, Tang N, Yokoo T, Okajima Y, Han SI, Takeuchi Y, Aita Y, Iwasaki H, Yatoh S, Suzuki H, Sekiya M, Yahagi N, Nakagawa Y, Sone H, Yamada N, Shimano H.
    • Journal Title

      Diabetes

      Volume: 66(7) Pages: 1833-1846

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] CoptidisツRhizoma induces intrinsic apoptosis through BAX and BAK activation in human melanoma.2017

    • Author(s)
      Xu X, Yokoyama S, Hayakawa Y, Saiki I.
    • Journal Title

      Oncol Rep

      Volume: 38(1) Pages: 538-544

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Microarray analyses of otospheres derived from the cochlea in the inner ear identify putative transcription factors that regulate the characteristics of otospheres.2017

    • Author(s)
      Iki T, Tanaka M, Kitajiri SI, Kita T, Kawasaki Y, Mizukoshi A, Fujibuchi W, Nakagawa T, Nakahata T, Ito J, Omori K, Saito MK.
    • Journal Title

      PLoS One

      Volume: 12(6)

    • NAID

      120006782202

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Book] 脂質メディエーターによるマスト細胞とアレルギー炎症の制御, アレルギーの臨床, 41 (2)2021

    • Author(s)
      村上誠
    • Publisher
      北隆館
    • Related Report
      2020 Annual Research Report
  • [Book] THE創薬 -少資源国家にっぽんの生きる道-2021

    • Author(s)
      酒井敏行
    • Publisher
      薬事日報社
    • Related Report
      2020 Annual Research Report
  • [Book] 脂質とアレルギー疾患, アレルギー, 69 (4)2020

    • Author(s)
      村上誠
    • Publisher
      一般社団法人 日本アレルギー学会
    • Related Report
      2020 Annual Research Report
  • [Book] 腸内細菌代謝産物による腎臓病の治療薬開発, ヒトマイクロバイオーム, Vol.22020

    • Author(s)
      岩田恭宜・中出祐介・和田隆志
    • Publisher
      エヌ・ティー・エス
    • Related Report
      2020 Annual Research Report
  • [Remarks]

    • URL

      http://inflammationcellularsociology.org/

    • Related Report
      2021 Annual Research Report
  • [Remarks] 予防を科学する炎症細胞社会学ホームページ

    • URL

      http://inflammationcellularsociology.org/

    • Related Report
      2020 Annual Research Report 2019 Annual Research Report 2018 Annual Research Report
  • [Remarks] 新学術領域研究 予防を科学する炎症細胞社会学 ホームページ

    • URL

      http://inflammationcellularsociology.org/

    • Related Report
      2017 Annual Research Report
  • [Funded Workshop] 文部科学省新学術領域研究 予防を科学する炎症細胞社会学 1st International Symposium on Inflammation Cellular Sociology(第1回国際シンポジウム)2019

    • Related Report
      2019 Annual Research Report

URL: 

Published: 2017-07-04   Modified: 2023-01-30  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi