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マルチスケール精神病態の構成的理解(総括班)

Organizer

Project AreaConstructive understanding of multi-scale dynamism of neuropsychiatric disorders
Project/Area Number 18H05428
Research Category

Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

Allocation TypeSingle-year Grants
Review Section Biological Sciences
Research InstitutionInstitute of Physical and Chemical Research (2019-2022)
Gunma University (2018)

Principal Investigator

高木 朗子 (林朗子 / 林 朗子 / 高木朗子)  国立研究開発法人理化学研究所, 脳神経科学研究センター, チームリーダー (60415271)

Co-Investigator(Kenkyū-buntansha) 澤田 誠  名古屋大学, 環境医学研究所, 教授 (10187297)
古屋敷 智之  神戸大学, 医学研究科, 教授 (20362478)
加藤 忠史  順天堂大学, 医学部, 教授 (30214381)
岩本 和也  熊本大学, 大学院生命科学研究部(医), 教授 (40342753)
那波 宏之  和歌山県立医科大学, 薬学部, 教授 (50183083)
喜田 聡  東京大学, 大学院農学生命科学研究科(農学部), 教授 (80301547)
林 康紀  京都大学, 医学研究科, 教授 (90466037)
吉川 武男  国立研究開発法人理化学研究所, 脳神経科学研究センター, チームリーダー (30249958)
Project Period (FY) 2018-06-29 – 2023-03-31
Project Status Granted (Fiscal Year 2022)
Budget Amount *help
¥271,310,000 (Direct Cost: ¥208,700,000、Indirect Cost: ¥62,610,000)
Fiscal Year 2022: ¥38,220,000 (Direct Cost: ¥29,400,000、Indirect Cost: ¥8,820,000)
Fiscal Year 2021: ¥33,670,000 (Direct Cost: ¥25,900,000、Indirect Cost: ¥7,770,000)
Fiscal Year 2020: ¥39,390,000 (Direct Cost: ¥30,300,000、Indirect Cost: ¥9,090,000)
Fiscal Year 2019: ¥37,440,000 (Direct Cost: ¥28,800,000、Indirect Cost: ¥8,640,000)
Fiscal Year 2018: ¥122,590,000 (Direct Cost: ¥94,300,000、Indirect Cost: ¥28,290,000)
Keywordsマルチスケール / マイクロ精神病態 / 構成的理解 / モデリング / トランスオミクス / 精神疾患 / 種間横断比較 / シミュレーション
Outline of Annual Research Achievements

FY2020はコロナ禍の中でも領域活動をなるべく高いレベルで維持し、領域が意義のあるバーチャル研究所として機能することに注力した。領域運営の企画調整は、2回/年の総括班会議をビデオ会議で開催した。協議事項は、領域会議や若手育成合宿などの運営方針、研究支援活動を促進するための方策、ニュースレター内容、公募研究採択方針など多岐にわたった。領域会議は、第3回をWEB開催(2020年7月3~4日)し、100名強の研究者の活発な議論が行われた。第2回若手育成セミナー(2020年12月16日)は、最先端技術に関する対話式ワークショップをWEB開催し、多くの若手研究者の参加があった。研究支援委員会では、技術や生物試料(iPS細胞、死後脳など)の供与などを介して、領域全体へ支援活動を行った。その結果、前年度に引き続き、領域内共同研究は順調に進行していると報告を受けている。有機的な人的交流も活発で、あるWET研究の計画班員の研究室で学位を取得した学生が、Dry研究をしている計画班員の研究室に博士研究員として異動するなど、領域のWET-DRY融合理念が草の根的に広がっている。ニュースレターは第4版を出版する予定で、若手研究者にむけた多くのコンテンツを予定しているとともに、領域の活動を広く周知するために工夫する。

Current Status of Research Progress
Current Status of Research Progress

2: Research has progressed on the whole more than it was originally planned.

Reason

コロナ禍にもかかわらず、オンラインなどを利活用し、領域内連携の維持ができているため。

Strategy for Future Research Activity

第4回領域会議(2021年5月18日、Zoom)、第3回若手育成セミナー(2021年12月18日、Zoom)などの領域活動を例年と同じ規模で開催する。とりわけ、若手育成合宿は、基礎と臨床との融合に焦点を絞った本領域ならではの刺激的な対話性のワークショップを目指す。

Report

(3 results)
  • 2020 Annual Research Report
  • 2019 Annual Research Report
  • 2018 Annual Research Report

Research Products

(32 results)

All 2021 2020 2019 2018 Other

All Journal Article (23 results) (of which Int'l Joint Research: 11 results,  Peer Reviewed: 23 results,  Open Access: 17 results) Presentation (8 results) (of which Int'l Joint Research: 4 results,  Invited: 8 results) Remarks (1 results)

  • [Journal Article] Optical interrogation of multi-scale neuronal plasticity underlying behavioral learning2021

    • Author(s)
      Tsutsumi Shinichiro、Hayashi-Takagi Akiko
    • Journal Title

      Current Opinion in Neurobiology

      Volume: 67 Pages: 8-15

    • DOI

      10.1016/j.conb.2020.07.002

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] CaMKII activation persistently segregates postsynaptic proteins via liquid phase separation2021

    • Author(s)
      Hosokawa Tomohisa、Liu Pin-Wu、Cai Qixu、Ferreira Joana S.、Levet Florian、Butler Corey、Sibarita Jean-Baptiste、Choquet Daniel、Groc Laurent、Hosy Eric、Zhang Mingjie、Hayashi Yasunori
    • Journal Title

      Nature Neuroscience

      Volume: -

    • DOI

      10.1038/s41593-021-00843-3

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Resting-state dopaminergic cell firing in the ventral tegmental area negatively regulates affiliative social interactions in a developmental animal model of schizophrenia2021

    • Author(s)
      Sotoyama Hidekazu、Namba Hisaaki、Kobayashi Yutaro、Hasegawa Taku、Watanabe Dai、Nakatsukasa Ena、Sakimura Kenji、Furuyashiki Tomoyuki、Nawa Hiroyuki
    • Journal Title

      Transl Psychiatry

      Volume: 11 Pages: 236-236

    • DOI

      10.1038/s41398-021-01346-2

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Developmental excitation-inhibition imbalance underlying psychoses revealed by single-cell analyses of discordant twins-derived cerebral organoids2020

    • Author(s)
      Sawada Tomoyo、Chater Thomas E.、Sasagawa Yohei、Yoshimura Mika、Fujimori-Tonou Noriko、Tanaka Kaori、Benjamin Kynon J. M.、Paquola Apu C. M.、Erwin Jennifer A.、Goda Yukiko、Nikaido Itoshi、Kato Tadafumi
    • Journal Title

      Molecular Psychiatry

      Volume: 25 Pages: 2695-2711

    • DOI

      10.1038/s41380-020-0844-z

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Evidence for Altered Metabolism of Sphingosine-1-phosphate in the Corpus Callosum of Patients with Schizophrenia2020

    • Author(s)
      Esaki, K., Balan, S., Iwayama, Y., Shimamoto-Mitsuyama, C., Hirabayashi, Y., Dean, B. & Yoshikawa, T.
    • Journal Title

      Schizophrenia Bulletin

      Volume: - Pages: 1172-1181

    • DOI

      10.1093/schbul/sbaa052

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Two functionally distinct serotonergic projections into hippocampus2020

    • Author(s)
      Luchetti Alessandro、Bota Ayaka、Weitemier Adam、Mizuta Kotaro、Sato Masaaki、Islam Tanvir、McHugh Thomas J.、Tashiro Ayumu、Hayashi Yasunori
    • Journal Title

      The Journal of Neuroscience

      Volume: - Pages: 4936-4944

    • DOI

      10.1523/jneurosci.2724-19.2020

    • NAID

      120006893992

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Investigation of betaine as a novel psychotherapeutic for schizophrenia2019

    • Author(s)
      Ohnishi T, Balan S, Toyoshima M, Maekawa M, Ohba H, Watanabe A, Iwayama Y, Hisano Y, Nagaoka A, Hino M, Kunii Y, Kakita A, Yabe H, Yoshikawa T.
    • Journal Title

      EBioMedicine

      Volume: 45 Pages: 432-446

    • DOI

      10.1016/j.ebiom.2019.05.062

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Hippocampal clock regulates memory retrieval via Dopamine and PKA-induced GluA1 phosphorylation2019

    • Author(s)
      Hasegawa Shunsuke、Fukushima Hotaka、Hosoda Hiroshi、Serita Tatsurou、Ishikawa Rie、Rokukawa Tomohiro、Kawahara-Miki Ryouka、Zhang Yue、Ohta Miho、Okada Shintaro、Tanimizu Toshiyuki、Josselyn Sheena A.、Frankland Paul W.、Kida Satoshi
    • Journal Title

      Nature Communications

      Volume: 10 Pages: 5766-5766

    • DOI

      10.1038/s41467-019-13554-y

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Reciprocal Activation within a Kinase-Effector Complex Underlying Persistence of Structural LTP.2019

    • Author(s)
      Saneyoshi T, Matsuno H, Suzuki A, Murakoshi H, Hedrick NG, Agnello E, O'Connell R, Stratton MM, Yasuda R, and Hayashi Y
    • Journal Title

      Neuron

      Volume: 102 Pages: 11991210-11991210

    • DOI

      10.1016/j.neuron.2019.04.012

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] A Bayesian psychophysics model of sense of agency2019

    • Author(s)
      Legaspi Roberto、Toyoizumi Taro
    • Journal Title

      Nature Communications

      Volume: 10 Pages: 4250-4250

    • DOI

      10.1038/s41467-019-12170-0

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Roles of multiple lipid mediators in stress and depression2019

    • Author(s)
      Furuyashiki Tomoyuki、Akiyama Satoshi、Kitaoka Shiho
    • Journal Title

      International Immunology

      Volume: 未定 Pages: 579-587

    • DOI

      10.1093/intimm/dxz023

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Social defeat stress induces phosphorylation of extracellular signal-regulated kinase in the leptomeninges in mice2019

    • Author(s)
      Okamura Satoshi、Nagai Hirotaka、Numa Chisato、Nagai Midori、Shinohara Ryota、Furuyashiki Tomoyuki
    • Journal Title

      Neuropsychopharmacology Reports

      Volume: -

    • DOI

      10.1002/npr2.12051

    • NAID

      120006713572

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Iso-α-acids, the bitter components of beer, improve hippocampus-dependent memory through vagus nerve activation2019

    • Author(s)
      Ano Yasuhisa、Hoshi Ayaka、Ayabe Tatsuhiro、Ohya Rena、Uchida Shinichi、Yamada Koji、Kondo Keiji、Kitaoka Shiho、Furuyashiki Tomoyuki
    • Journal Title

      The FASEB Journal

      Volume: ー Pages: 4987-4995

    • DOI

      10.1096/fj.201801868rr

    • NAID

      120006619816

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Somatic mutations in the human brain : implications for psychiatric research2019

    • Author(s)
      Nishioka M, Bundo M, Iwamoto K, Kato T
    • Journal Title

      Molecular Psychiatry

      Volume: - Pages: 839-856

    • DOI

      10.1038/s41380-018-0129-y

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Making psychiatry a clinical neuroscience-based medicine2019

    • Author(s)
      Kato Tadafumi、Kanba Shigenobu
    • Journal Title

      Psychiatry and Clinical Neurosciences

      Volume: 73 Pages: 1-1

    • DOI

      10.1111/pcn.12798

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] GABARAPs dysfunction by autophagy deficiency in adolescent brain impairs GABAA receptor trafficking and social behavior2019

    • Author(s)
      Hui Kelvin K.、Takashima Noriko、Watanabe Akiko、Chater Thomas E.、Matsukawa Hiroshi、Nekooki-Machida Yoko、Nilsson Per、Endo Ryo、Goda Yukiko、Saido Takaomi C.、Yoshikawa Takeo、Tanaka Motomasa
    • Journal Title

      Sci Adv.

      Volume: 5

    • DOI

      10.1126/sciadv.aau8237

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Key role of soluble epoxide hydrolase in the neurodevelopmental disorders of offspring after maternal immune activation2019

    • Author(s)
      Ma Min、Ren Qian、Yang Jun、Zhang Kai、Xiong Zhongwei、Ishima Tamaki、Pu Yaoyu、Hwang Sung Hee、Toyoshima Manabu、Iwayama Yoshimi、Hisano Yasuko、Yoshikawa Takeo、Hammock Bruce D.、Hashimoto Kenji
    • Journal Title

      Proc Natl Acad Sci U S A.

      Volume: 116 Pages: 7083-7088

    • DOI

      10.1073/pnas.1819234116

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Evaluation of the role of fatty acid-binding protein 7 in controlling schizophrenia-relevant phenotypes using newly established knockout mice2019

    • Author(s)
      Shimamoto-Mitsuyama Chie、Ohnishi Tetsuo、Balan Shabeesh、Ohba Hisako、Watanabe Akiko、Maekawa Motoko、Hisano Yasuko、Iwayama Yoshimi、Owada Yuji、Yoshikawa Takeo
    • Journal Title

      Schizophrenia Research

      Volume: -

    • DOI

      10.1016/j.schres.2019.02.002

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Autophosphorylation of F-actin binding domain of CaMKIIβ is required for fear learning2019

    • Author(s)
      Kim Karam、Suzuki Akio、Kojima Hiroto、Kawamura Meiko、Miya Ken、Abe Manabu、Yamada Ikuko、Furuse Tamio、Wakana Shigenaru、Sakimura Kenji、Hayashi Yasunori
    • Journal Title

      Neurobiology of Learning and Memory

      Volume: 157 Pages: 86-95

    • DOI

      10.1016/j.nlm.2018.12.003

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Chemical Landscape for Tissue Clearing Based on Hydrophilic Reagents.2018

    • Author(s)
      Tainaka K. Murakami TC, Susaki EA, Shimizu C, Saito R, Takahashi K, Hayashi-Takagi A, Sekiya H, Arima Y, Nojima S, Ikemura M, Ushiku T, Shimizu Y, Murakami M, Tanaka KF, Iino M, Kasai H, Sasaoka T. Kobayashi K, Miyazono K, Morii E, Isa T, Fukayama M, Kakita A. Ueda HR.
    • Journal Title

      Cell Reports

      Volume: 24 Pages: 2196-2210

    • DOI

      10.1016/j.celrep.2018.07.056

    • NAID

      120006542018

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Pathological alterations of chondroitin sulfate moiety in postmortem hippocampus of patients with schizophrenia2018

    • Author(s)
      Yukawa t, Iwakura Y, Takei N, Saito M, Watanabe Y, Toyooka K, Igarashi, M, Niizato K, Oshima K, Kunii Y, Yabe H, Matsumoto J, Wada A, Hino M, Iritani S, Niwa S, Takeuchi R. Takahashi H, Kakita A, Someya T, *Nawa H
    • Journal Title

      Psychiatry Res

      Volume: 270 Pages: 940-946

    • DOI

      10.1016/j.psychres.2018.10.062

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Trans-omic Analysis Reveals Selective Responses to Induced and Basal Insulin across Signaling, Transcriptional, and Metabolic Networks2018

    • Author(s)
      Kawata Kentaro、Hatano Atsushi、Yugi Katsuyuki、Kubota Hiroyuki、Sano Takanori、Fujii Masashi、Tomizawa Yoko、Kokaji Toshiya、Tanaka Kaori Y.、Uda Shinsuke、Suzuki Yutaka、Matsumoto Masaki、Nakayama Keiichi I.、Saitoh Kaori、Kato Keiko、Ueno Ayano、Ohishi Maki、Hirayama Akiyoshi、Soga Tomoyoshi、Kuroda Shinya
    • Journal Title

      iScience

      Volume: 7 Pages: 212-229

    • DOI

      10.1016/j.isci.2018.07.022

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Mitochondrial dysfunction causes hyperexcitability of serotonergic neurons2018

    • Author(s)
      Kato Tomoaki M.、Kubota-Sakashita Mie、Fujimori-Tonou Noriko、Saitow Fumihito、Fuke Satoshi、Masuda Akira、Itohara Shigeyoshi、Suzuki Hidenori、Kato Tadafumi
    • Journal Title

      Molecular Psychiatry

      Volume: 23 Pages: 1971-1971

    • DOI

      10.1038/s41380-018-0295-y

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Presentation] Multi-scale Understanding of Synaptic Pathology of Psychiatric Disorders2021

    • Author(s)
      Akiko Hayahshi-Takagi
    • Organizer
      The 11th BRI Int'l Symposium
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Multi-scale Understanding of Synaptic Pathology of Psychiatric Disorders2021

    • Author(s)
      Akiko Hayahshi-Takagi
    • Organizer
      第98回日本生理学会大会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] Multi-scale Understanding of Synaptic Pathology of Psychiatric Disorders2020

    • Author(s)
      Akiko Hayahshi-Takagi
    • Organizer
      遺伝研研究会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] Multi-scale Understanding of Synaptic Pathology of Psychiatric Disorders2020

    • Author(s)
      Akiko Hayahshi-Takagi
    • Organizer
      第43回日本分子生物学会年会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] Multi-scale Understanding of Synaptic Pathology of Psychiatric Disorders2019

    • Author(s)
      Akiko Hayahshi-Takagi
    • Organizer
      1st international symposium of Multiscale Brain
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Intrinsic spine dynamics are critical for recurrent network learning in models with and without autism spectrum disorder2019

    • Author(s)
      Taro Toyoizumi
    • Organizer
      1st international symposium of Multiscale Brain
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Molecular mechanism of hippocampal synaptic plasticity2019

    • Author(s)
      Yasunori Hayashi
    • Organizer
      1st international symposium of Multiscale Brain
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Roles and mechanisms of neuroinflammation in stress and depression2019

    • Author(s)
      Tomyuki Furuyashiki
    • Organizer
      1st international symposium of Multiscale Brain
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Remarks] マルチスケール精神病態の構成的理解

    • URL

      http://multiscale-brain.umin.ne.jp/

    • Related Report
      2019 Annual Research Report

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Published: 2018-07-20   Modified: 2022-07-01  

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