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New frontier for ubiquitin biology driven by chemo-technologies

Administrative Group

Project AreaNew frontier for ubiquitin biology driven by chemo-technologies
Project/Area Number 18H05497
Research Category

Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

Allocation TypeSingle-year Grants
Review Section Complex systems
Research InstitutionTokyo Metropolitan Institute of Medical Science

Principal Investigator

佐伯 泰  公益財団法人東京都医学総合研究所, 基礎医科学研究分野, プロジェクトリーダー (80462779)

Co-Investigator(Kenkyū-buntansha) 内藤 幹彦  東京大学, 大学院薬学系研究科(薬学部), 特任教授 (00198011)
村田 茂穂  東京大学, 大学院薬学系研究科(薬学部), 教授 (20344070)
岩井 一宏  京都大学, 医学研究科, 教授 (60252459)
深井 周也  東京大学, 定量生命科学研究所, 委嘱教授 (10361792)
出水 庸介  国立医薬品食品衛生研究所, 有機化学部, 部長 (90389180)
岡本 晃充  東京大学, 先端科学技術研究センター, 教授 (60314233)
Project Period (FY) 2018-06-29 – 2023-03-31
Project Status Granted (Fiscal Year 2022)
Budget Amount *help
¥229,320,000 (Direct Cost: ¥176,400,000、Indirect Cost: ¥52,920,000)
Fiscal Year 2022: ¥9,620,000 (Direct Cost: ¥7,400,000、Indirect Cost: ¥2,220,000)
Fiscal Year 2021: ¥9,620,000 (Direct Cost: ¥7,400,000、Indirect Cost: ¥2,220,000)
Fiscal Year 2020: ¥14,430,000 (Direct Cost: ¥11,100,000、Indirect Cost: ¥3,330,000)
Fiscal Year 2019: ¥14,430,000 (Direct Cost: ¥11,100,000、Indirect Cost: ¥3,330,000)
Fiscal Year 2018: ¥181,220,000 (Direct Cost: ¥139,400,000、Indirect Cost: ¥41,820,000)
Keywordsユビキチン / ケミカルバイオロジー / 翻訳後修飾 / タンパク質分解 / シグナル伝達 / 標的タンパク質分解誘導剤 / ステープルペプチド
Outline of Annual Research Achievements

本新学術領域研究では、ユビキチン・プロテアソーム研究の国内リーダーと低分子化合物・ペプチド工学を専門とする有機化学者を結集し、ユビキチンにフォーカスしたケモテクノロジーを共に開発することで、次世代型ユビキチン研究を推進する。本領域の成否は異分野研究者の連携が最重要であるため、総括班が領域全体の研究体制、研究手法、情報共有を強力に支援し、領域の円滑かつ効率的な運営を進める。2021年度は以下の活動を実施した。
(1)総括班会議:2022年2月12日に開催し、異分野連携領域内共同研究の推進や若手研究者育成の方策、学会活動、企業との連携、領域主催国際シンポジウムの準備等について協議することで今後の領域の運営方針を決定した。
(2)領域全体会議:2021年6月26日および2022年2月11日~13日の計2回オンライン開催した。6月26日開催の第5回領域班会議では、第2期公募研究班員24名の研究計画を中心に発表し、以後の領域内共同研究の契機とした。2月開催の第6回領域班会議では、計画研究・公募研究の全班員が研究成果を発表し、研究の進展状況、領域内共同研究の実施状況が良好であることを確認した。
(3)研究支援:現在、領域内共同研究として約100件の研究課題が実施中であり、総括班による研究支援や共同研究のマッチング等も十分であった。
(4)若手育成支援:若手研究者、大学院生の発表を中心とした若手主体発表会を2回オンライン開催し、いずれも120名以上の参加者があった。
(5)広報活動:領域ホームページを定期的に更新するとともに、ニュースレターを540部発行した。また、日本生化学会大会、日本分子生物学会年会において本領域の共催シンポジウムを開催した(参加者170名)。

Current Status of Research Progress
Current Status of Research Progress

2: Research has progressed on the whole more than it was originally planned.

Reason

2021年度は24件の公募研究が加わり新学術領域研究としての後半戦が開始した。領域全体会議、総括班会議、若手主体会議、ホームページや学会活動による情報発信については、当初計画の通り実施した。一方、若手研究者の国際学会参加や他の研究分野・企業研究者との交流については、コロナ禍により領域としての活動が制限され、各班員の個々の活動に依るものが多かった。
第5回領域班会議、第6回領域班会議はいずれも約130名の参加者があり、オンラインでの開催であったが、討議時間を比較的長めに設定することでユビキチン研究者と有機化学者が密な議論を交わすことができた。本年度は、デコイ核酸型PROTACや疎水性タグを用いたPROTACの開発、in silicoデザインによるPROTACの合理的設計など、標的タンパク質分解誘導剤の開発の進展が目覚ましく、また、ユビキチンデコーダーや脱ユビキチン化酵素の分子研究も大きく進み、また、新規開発された化学ツールを活用したユビキチン研究も順調に進んでいる。実際、研究成果としては、100報を超える論文発表があった。また、本領域に関する総説論文集を細胞誌に発表した。一方、昨年度に引き続き、本年度も若手の班員4名が各学会の奨励賞を受賞するなど次世代を担う若手研究者の育成も順調であるといえる。
このように総括班の活動はおおむね順調に進展していると判断される。

Strategy for Future Research Activity

最終年度となる2022年度は以下の活動を計画している。
(1)領域運営会議:2月に総括班会議を実施するほか、計画研究班員が3ヶ月ごとに会し、各自の研究成果と研究方法を共有すると共に、国内外の学術動向を議論し、以降の研究計画の調整および研究・運営方針を策定する。(佐伯)
(2)領域班会議:本年度は2月に領域班会議を開催する。領域班会議は2日間の日程で計画研究班員、公募研究班員が成果発表を行い、本領域の研究成果を総括する。また、12月開催予定の領域主催国際シンポジウムにおいて、班員の研究成果を世界に発信する。(岩井)
(3)共同研究推進活動:質量分析解析、低分子化合物スクリーニング、ペプチド合成、構造解析などの研究支援を班員に周知し、領域内共同研究活動を円滑に推進するべく調整する。(内藤)
(4)若手育成支援:若手研究者による若手主体研究発表会を2回開催する。また、若手研究者の国際学会参加を促進させるため海外旅費支援を実施する(5名程度)。これらの活動により次世代研究者の交流・育成を図る。(佐伯)
(5)広報活動:本領域のホームページを充実させるとともに、本領域の研究活動を網羅したニュースレターを発刊する。また、国内の主要学会(日本ケミカルバイオロジー学会、日本細胞生物学会、日本分子生物学会等)において領域共催シンポジウムを開催し、本領域の研究活動を宣伝する。(村田)

Report

(3 results)
  • 2021 Annual Research Report
  • 2019 Annual Research Report
  • 2018 Annual Research Report

Research Products

(110 results)

All 2022 2021 2020 2019 2018 Other

All Int'l Joint Research (5 results) Journal Article (47 results) (of which Int'l Joint Research: 20 results,  Peer Reviewed: 47 results,  Open Access: 32 results) Presentation (52 results) (of which Int'l Joint Research: 9 results,  Invited: 49 results) Remarks (6 results)

  • [Int'l Joint Research] Max Planck Institute of Biochemistry/University of Munich(ドイツ)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] Washington University/University of Illinois at Chicago/The Scripps Research Institute(米国)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] Washington University/University of Illinois at Chicago(米国)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] National Center of Biomedical Analysis(中国)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] Max Planck Institute of Biochemistry(ドイツ)

    • Related Report
      2018 Annual Research Report
  • [Journal Article] ENTREP/FAM189A2 encodes a new ITCH ubiquitin ligase activator that is downregulated in breast cancer2022

    • Author(s)
      Takumi Tsunoda, Miho Riku, Norika Yamada, Hikaru Tsuchiya, Takuya Tomita, Minako Suzuki, Mari Kizuki, Akihito Inoko, Hideaki Ito, Kenta Murotani, Hideki Murakami, Yasushi Saeki, Kenji Kasai
    • Journal Title

      EMBO reports

      Volume: 23 Issue: 2

    • DOI

      10.15252/embr.202051182

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Development of a Hematopoietic Prostaglandin D Synthase-Degradation Inducer2021

    • Author(s)
      Yokoo Hidetomo、Shibata Norihito、Naganuma Miyako、Murakami Yuki、Fujii Kiyonaga、Ito Takahito、Aritake Kosuke、Naito Mikihiko、Demizu Yosuke
    • Journal Title

      ACS Medicinal Chemistry Letters

      Volume: 12 Issue: 2 Pages: 236-241

    • DOI

      10.1021/acsmedchemlett.0c00605

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] MIND bomb 2 prevents RIPK1 kinase activity-dependent and -independent apoptosis through ubiquitylation of cFLIPL2021

    • Author(s)
      Nakabayashi Osamu、Takahashi Hirotaka、Moriwaki Kenta、Komazawa-Sakon Sachiko、Ohtake Fumiaki、Murai Shin、Tsuchiya Yuichi、Koyahara Yuki、Saeki Yasushi、Yoshida Yukiko、Yamazaki Soh、Tokunaga Fuminori、Sawasaki Tatsuya、Nakano Hiroyasu
    • Journal Title

      Communications Biology

      Volume: 4 Issue: 1 Pages: 80-80

    • DOI

      10.1038/s42003-020-01603-y

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] TRIP12 promotes small-molecule-induced degradation through K29/K48-branched ubiquitin chains2021

    • Author(s)
      Kaiho-Soma Ai、Akizuki Yoshino、Igarashi Katsuhide、Endo Akinori、Shoda Takuji、Kawase Yasuko、Demizu Yosuke、Naito Mikihiko、Saeki Yasushi、Tanaka Keiji、Ohtake Fumiaki
    • Journal Title

      Molecular Cell

      Volume: 81 Issue: 7 Pages: 1411-1424.e7

    • DOI

      10.1016/j.molcel.2021.01.023

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The ubiquitination-deubiquitination cycle on the ribosomal protein eS7A is crucial for efficient translation2021

    • Author(s)
      Takehara Yuka、Yashiroda Hideki、Matsuo Yoshitaka、Zhao Xian、Kamigaki Akane、Matsuzaki Tetsuo、Kosako Hidetaka、Inada Toshifumi、Murata Shigeo
    • Journal Title

      iScience

      Volume: 24 Issue: 3 Pages: 102145-102145

    • DOI

      10.1016/j.isci.2021.102145

    • NAID

      120007182109

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Development of Agonist-Based PROTACs Targeting Liver X Receptor2021

    • Author(s)
      Xu Hanqiao、Ohoka Nobumichi、Yokoo Hidetomo、Nemoto Kanako、Ohtsuki Takashi、Matsufuji Hiroshi、Naito Mikihiko、Inoue Takao、Tsuji Genichiro、Demizu Yosuke
    • Journal Title

      Frontiers in Chemistry

      Volume: 9 Pages: 674967-674967

    • DOI

      10.3389/fchem.2021.674967

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Loss of peptide: N -glycanase causes proteasome dysfunction mediated by a sugar-recognizing ubiquitin ligase2021

    • Author(s)
      Yoshida Yukiko、Asahina Makoto、Murakami Arisa、Kawawaki Junko、Yoshida Meari、Fujinawa Reiko、Iwai Kazuhiro、Tozawa Ryuichi、Matsuda Noriyuki、Tanaka Keiji、Suzuki Tadashi
    • Journal Title

      Proceedings of the National Academy of Sciences

      Volume: 118 Issue: 27

    • DOI

      10.1073/pnas.2102902118

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Peptide Stapling Improves the Sustainability of a Peptide-Based Chimeric Molecule That Induces Targeted Protein Degradation2021

    • Author(s)
      Yokoo Hidetomo、Ohoka Nobumichi、Takyo Mami、Ito Takahito、Tsuchiya Keisuke、Kurohara Takashi、Fukuhara Kiyoshi、Inoue Takao、Naito Mikihiko、Demizu Yosuke
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 22 Issue: 16 Pages: 8772-8772

    • DOI

      10.3390/ijms22168772

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Discovery of a Highly Potent and Selective Degrader Targeting Hematopoietic Prostaglandin D Synthase via In Silico Design2021

    • Author(s)
      Yokoo Hidetomo、Shibata Norihito、Endo Akinori、Ito Takahito、Yanase Yuta、Murakami Yuki、Fujii Kiyonaga、Hamamura Kengo、Saeki Yasushi、Naito Mikihiko、Aritake Kosuke、Demizu Yosuke
    • Journal Title

      Journal of Medicinal Chemistry

      Volume: 64 Issue: 21 Pages: 15868-15882

    • DOI

      10.1021/acs.jmedchem.1c01206

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Heterozygous missense variant of the proteasome subunit β-type 9 causes neonatal-onset autoinflammation and immunodeficiency2021

    • Author(s)
      Kanazawa N, Hemmi H, Kinjo N, Ohnishi H, Hamazaki J, M.H, K.A, M.T, H.S, K.N, K.S, H.Y, I.K, N.R, T.M, Y.Y, T.S, O.T, O.T, K.T, S.I, F.Y, W.N, I.Y, K.K, O.S, T.T, N.K, M.S, Y.K, Kaisho T
    • Journal Title

      Nature Communications

      Volume: 12 Issue: 1 Pages: 0-0

    • DOI

      10.1038/s41467-021-27085-y

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Gluing Proteins for Targeted Degradation2021

    • Author(s)
      Naito Mikihiko、Murata Shigeo
    • Journal Title

      Cancer Cell

      Volume: 39 Issue: 1 Pages: 19-21

    • DOI

      10.1016/j.ccell.2020.12.020

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Development of Chimeric Molecules That Degrade the Estrogen Receptor Using Decoy Oligonucleotide Ligands2021

    • Author(s)
      Naganuma M, Ohoka N, Tsuji G, Tsujimura H, Matsuno K, Inoue T, Naito M, Demizu Y.
    • Journal Title

      ACS Med Chem Lett.

      Volume: 13 Issue: 1 Pages: 134-139

    • DOI

      10.1021/acsmedchemlett.1c00629

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] A novel method to determine the chain length of the polyubiquitinated proteins2020

    • Author(s)
      土屋 光、佐伯 泰
    • Journal Title

      生化学

      Volume: 92 Issue: 1 Pages: 14-19

    • DOI

      10.14952/SEIKAGAKU.2020.920014

    • ISSN
      0037-1017
    • Year and Date
      2020-02-25
    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] LUBAC, the E3 ligase complex generating linear polyubiquitin chains2020

    • Author(s)
      佐々木克博、岩井一宏
    • Journal Title

      生化学

      Volume: 92 Issue: 1 Pages: 20-27

    • DOI

      10.14952/SEIKAGAKU.2020.920020

    • ISSN
      0037-1017
    • Year and Date
      2020-02-25
    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Recognition and degradation of ubiquitinated proteins by the 26S proteasome2020

    • Author(s)
      濱崎 純、村田 茂穂
    • Journal Title

      生化学

      Volume: 92 Issue: 1 Pages: 48-56

    • DOI

      10.14952/SEIKAGAKU.2020.920048

    • ISSN
      0037-1017
    • Year and Date
      2020-02-25
    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Stress- and ubiquitylation-dependent phase separation of the proteasome2020

    • Author(s)
      Yasuda Sayaka、Tsuchiya Hikaru、Kaiho Ai、Guo Qiang、Ikeuchi Ken、Endo Akinori、Arai Naoko、Ohtake Fumiaki、Murata Shigeo、Inada Toshifumi、Baumeister Wolfgang、Fernandez-Busnadiego Ruben、Tanaka Keiji、Saeki Yasushi
    • Journal Title

      Nature

      Volume: 578 Issue: 7794 Pages: 296-300

    • DOI

      10.1038/s41586-020-1982-9

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] The HOIL-1L ligase modulates immune signalling and cell death via monoubiquitination of LUBAC2020

    • Author(s)
      Fuseya Yasuhiro、Fujita Hiroaki、Kim Minsoo、Ohtake Fumiaki、Nishide Akira、Sasaki Katsuhiro、Saeki Yasushi、Tanaka Keiji、Takahashi Ryosuke、Iwai Kazuhiro
    • Journal Title

      Nature Cell Biology

      Volume: - Issue: 6 Pages: 663-673

    • DOI

      10.1038/s41556-020-0517-9

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] RQT complex dissociates ribosomes collided on endogenous RQC substrate SDD12020

    • Author(s)
      Matsuo Yoshitaka、Tesina Petr、Nakajima Shizuka、Mizuno Masato、Endo Akinori、Buschauer Robert、Cheng Jingdong、Shounai Okuto、Ikeuchi Ken、Saeki Yasushi、Becker Thomas、Beckmann Roland、Inada Toshifumi
    • Journal Title

      Nature Structural & Molecular Biology

      Volume: 27 Issue: 4 Pages: 323-332

    • DOI

      10.1038/s41594-020-0393-9

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Two distinct modes of DNMT1 recruitment ensure stable maintenance DNA methylation2020

    • Author(s)
      A. Nishiyama, C. Mulholland, S. Bultmann, S. Kori, A. Endo, Y. Saeki, W. Qin, C. Trummer, Y. Chiba, H. Yokoyama, S. Kumamoto, T. Kawakami, H. Hojo, G. Nagae, H. Aburatani, K. Tanaka, K. Arita, H. Leonhardt, M. Nakanishi
    • Journal Title

      Nat. Commun.

      Volume: 11 Issue: 1 Pages: 1222-1222

    • DOI

      10.1038/s41467-020-15006-4

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] タンパク質分解装置プロテアソームと創薬2020

    • Author(s)
      村田 茂穂、池浦 隆真
    • Journal Title

      Farumashia

      Volume: 56 Issue: 1 Pages: 11-15

    • DOI

      10.14894/faruawpsj.56.1_11

    • NAID

      130007779039

    • ISSN
      0014-8601, 2189-7026
    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 最先端プロテオミクス解析を用いたユビキチン研究2020

    • Author(s)
      佐伯 泰
    • Journal Title

      Farumashia

      Volume: 56 Issue: 1 Pages: 21-25

    • DOI

      10.14894/faruawpsj.56.1_21

    • NAID

      130007779041

    • ISSN
      0014-8601, 2189-7026
    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 新しい低分子薬の創薬モダリティPROTAC2020

    • Author(s)
      大岡 伸通、内藤 幹彦
    • Journal Title

      Farumashia

      Volume: 56 Issue: 1 Pages: 41-45

    • DOI

      10.14894/faruawpsj.56.1_41

    • NAID

      130007779032

    • ISSN
      0014-8601, 2189-7026
    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Different Degradation Mechanisms of Inhibitor of Apoptosis Proteins (IAPs) by the Specific and Nongenetic IAP-Dependent Protein Eraser (SNIPER)2019

    • Author(s)
      Ohoka Nobumichi、Ujikawa Osamu、Shimokawa Kenichiro、Sameshima Tomoya、Shibata Norihito、Hattori Takayuki、Nara Hiroshi、Cho Nobuo、Naito Mikihiko
    • Journal Title

      Chemical and Pharmaceutical Bulletin

      Volume: 67 Issue: 3 Pages: 203-209

    • DOI

      10.1248/cpb.c18-00567

    • NAID

      130007607114

    • ISSN
      0009-2363, 1347-5223
    • Year and Date
      2019-03-01
    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Development of a Potent Protein Degrader against Oncogenic BCR-ABL Protein2019

    • Author(s)
      Shibata Norihito、Ohoka Nobumichi、Hattori Takayuki、Naito Mikihiko
    • Journal Title

      Chemical and Pharmaceutical Bulletin

      Volume: 67 Issue: 3 Pages: 165-172

    • DOI

      10.1248/cpb.c18-00703

    • NAID

      130007606378

    • ISSN
      0009-2363, 1347-5223
    • Year and Date
      2019-03-01
    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] p63 is a cereblon substrate involved in thalidomide teratogenicity2019

    • Author(s)
      Asatsuma-Okumura Tomoko、Ando Hideki、De Simone Marco、Yamamoto Junichi、Sato Tomomi、Shimizu Nobuyuki、Asakawa Kazuhide、Yamaguchi Yuki、Ito Takumi、Guerrini Luisa、Handa Hiroshi
    • Journal Title

      Nature Chemical Biology

      Volume: 15 Issue: 11 Pages: 1077-1084

    • DOI

      10.1038/s41589-019-0366-7

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Modulation of autoimmune pathogenesis by T cell-triggered inflammatory cell death.2019

    • Author(s)
      Sasaki, K., Himeno, A., Nakagawa, T., Sasaki, Y., Kiyonari, H. and Iwai, K.
    • Journal Title

      Nature Communications

      Volume: 10 Issue: 1 Pages: 3878-3878

    • DOI

      10.1038/s41467-019-11858-7

    • NAID

      120006716601

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Structural insights into ubiquitin recognition and Ufd1 interaction of Npl42019

    • Author(s)
      Sato Yusuke、Tsuchiya Hikaru、Yamagata Atsushi、Okatsu Kei、Tanaka Keiji、Saeki Yasushi、Fukai Shuya
    • Journal Title

      Nature Communications

      Volume: 10 Issue: 1 Pages: 5708-5708

    • DOI

      10.1038/s41467-019-13697-y

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Development of small molecule chimeric degraders that bring target proteins and the aryl hydrocarbon receptor (AhR) E3 ligase into close proximity2019

    • Author(s)
      N. Ohoka, G. Tsuji, T. Shoda, T. Fujisato, M. Kurihara, Y. Demizu, M. Naito*
    • Journal Title

      ACS Chem. Biol.

      Volume: 14 Issue: 12 Pages: 2822-2832

    • DOI

      10.1021/acschembio.9b00704

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Development of 2-aminoisobutyric acid (Aib)-rich cell-penetrating peptide foldamers for efficient siRNA delivery2019

    • Author(s)
      T. Misawa,* N. Ohoka,* M. Oba, H. Yamashita, M. Tanaka, M. Naito, Y. Demizu*
    • Journal Title

      Chem. Commun.

      Volume: 55 Issue: 54 Pages: 7792-7795

    • DOI

      10.1039/c9cc02203a

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cysteinylprolyl imide (CPI) peptide: a highly reactive and easily accessible crypto-thioester for chemical protein synthesis2019

    • Author(s)
      Yanase Masafumi、Nakatsu Koki、Cardos Charlane Joy、Konda Yoshiki、Hayashi Gosuke、Okamoto Akimitsu
    • Journal Title

      Chemical Science

      Volume: 10 Issue: 23 Pages: 5967-5975

    • DOI

      10.1039/c9sc00646j

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Chemical Synthesis of Cys-Containing Protein via Chemoselective Deprotection with Different Palladium Complexes2019

    • Author(s)
      Kamo, N.; Hayashi, G.; Okamoto, A.
    • Journal Title

      Org. Lett.

      Volume: 21 Issue: 20 Pages: 8378-8382

    • DOI

      10.1021/acs.orglett.9b03152

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Collided ribosomes form a unique structural interface to induce Hel2‐driven quality control pathways2019

    • Author(s)
      Ikeuchi Ken、Tesina Petr、Matsuo Yoshitaka、Sugiyama Takato、Cheng Jingdong、Saeki Yasushi、Tanaka Keiji、Becker Thomas、Beckmann Roland、Inada Toshifumi
    • Journal Title

      The EMBO Journal

      Volume: 38 Issue: 5

    • DOI

      10.15252/embj.2018100276

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Methods to measure ubiquitin chain length and linkage.2019

    • Author(s)
      Ohtake, F., Tsuchiya, H., Tanaka, K., and Saeki, Y.
    • Journal Title

      Methods Enzymol

      Volume: 618 Pages: 105-133

    • DOI

      10.1016/bs.mie.2018.12.019

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Detection of ubiquitination activity and identification of ubiquitinated substrates using TR-TUBE2019

    • Author(s)
      Yoshida, Y., Saeki, Y., Tsuchiya, H., and Tanaka, K.
    • Journal Title

      Methods Enzymol

      Volume: 618 Pages: 135-147

    • DOI

      10.1016/bs.mie.2018.12.032

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] SNIPERs - Hijacking IAP activity to induce protein degradation.2019

    • Author(s)
      Naito M, Ohoka N, Shibata N.
    • Journal Title

      Drug Discovery Today: Technology

      Volume: 印刷中 Pages: 481-488

    • DOI

      10.1016/j.ddtec.2018.12.002

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Rational design of novel amphipathic antimicrobial peptides focused on the distribution of cationic amino acid residues2019

    • Author(s)
      Misawa T, Goto C, Shibata N, Hirano M, Kikuchi Y, Naito M, Demizu Y
    • Journal Title

      Med Chem Comm

      Volume: 印刷中 Issue: 6 Pages: 896-900

    • DOI

      10.1039/c9md00166b

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] LUBAC controls chromosome alignment by targeting CENP-E to attached kinetochores2019

    • Author(s)
      Wu Min、Chang Yan、Hu Huaibin、Mu Rui、Zhang Yucheng、Qin Xuanhe、Duan Xiaotao、Li Weihua、Tu Haiqing、Zhang Weina、Wang Guang、Han Qiuying、Li Ailing、Zhou Tao、Iwai Kazuhiro、Zhang Xuemin、Li Huiyan
    • Journal Title

      Nat. Commun.

      Volume: 10 Issue: 1 Pages: 273-273

    • DOI

      10.1038/s41467-018-08043-7

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Transcriptional regulation of the 26S proteasome by Nrf12018

    • Author(s)
      Koizumi S, Hamazaki J, Murata S.
    • Journal Title

      Proceedings of the Japan Academy, Series B

      Volume: 94 Issue: 8 Pages: 325-336

    • DOI

      10.2183/pjab.94.021

    • NAID

      130007497652

    • ISSN
      0386-2208, 1349-2896
    • Year and Date
      2018-10-11
    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Deubiquitylases USP5 and USP13 are recruited to and regulate heat-induced stress granules through their deubiquitylating activities2018

    • Author(s)
      Xie Xuan、Matsumoto Shunsuke、Endo Akinori、Fukushima Toshiaki、Kawahara Hiroyuki、Saeki Yasushi、Komada Masayuki
    • Journal Title

      Journal of Cell Science

      Volume: 131 Pages: 210856-210856

    • DOI

      10.1242/jcs.210856

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] HERC2 facilitates BLM and WRN helicase complex interaction with RPA to suppress G-quadruplex DNA.2018

    • Author(s)
      Wu W, Rokutanda N, Takeuchi J, Lai Y, Maruyama R, Togashi Y, Nishikawa H, Arai N, Miyoshi Y,Suzuki N, Saeki Y, Tanaka K, Ohta T.
    • Journal Title

      Cancer Res.

      Volume: 78 Issue: 22 Pages: 6371-6385

    • DOI

      10.1158/0008-5472.can-18-1877

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Specific modification of aged proteasomes revealed by tag-exchangeable knock-in mice.2018

    • Author(s)
      Tomita, T., Hirayama, S., Sakurai, Y., Ohte, Y., Yoshihara, H., Saeki, Y., Hamazaki, J., and Murata, S.
    • Journal Title

      Mol. Cell Biol.

      Volume: 39 Issue: 1

    • DOI

      10.1128/mcb.00426-18

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] PAC1-PAC2 proteasome assembly chaperone retains the core α4-α7 assembly intermediates in the cytoplasm.2018

    • Author(s)
      Wu W, Sahara K, Hirayama S, Zhao X, Watanabe A, Hamazaki J, Yashiroda H, Murata S.
    • Journal Title

      Gene to Cells

      Volume: 10 Issue: 10 Pages: 839-848

    • DOI

      10.1111/gtc.12631

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Nuclear export of ubiquitinated proteins via the UBIN-POST system2018

    • Author(s)
      S. Hirayama, M. Sugihara, D. Morito, S. Iemura, T. Natsume, K. Nagata
    • Journal Title

      Proc. Natl. Acad. Sci. USA

      Volume: in press Issue: 18

    • DOI

      10.1073/pnas.1711017115

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The immunoproteasome and thymoproteasome: functions, evolution and human disease2018

    • Author(s)
      Murata S, Takahama Y, Kasahara M, Tanaka K
    • Journal Title

      Nature Immunol.

      Volume: 19 Issue: 9 Pages: 923-931

    • DOI

      10.1038/s41590-018-0186-z

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Pharmacological difference between degrader and inhibitor against oncogenic BCR-ABL kinase2018

    • Author(s)
      Shibata Norihito、Shimokawa Kenichiro、Nagai Katsunori、Ohoka Nobumichi、Hattori Takayuki、Miyamoto Naoki、Ujikawa Osamu、Sameshima Tomoya、Nara Hiroshi、Cho Nobuo、Naito Mikihiko
    • Journal Title

      Scientific Reports

      Volume: 8 Issue: 1 Pages: 13549-13549

    • DOI

      10.1038/s41598-018-31913-5

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Derivatization of inhibitor of apoptosis protein (IAP) ligands yields improved inducers of estrogen receptor α degradation2018

    • Author(s)
      Ohoka Nobumichi、Morita Yoko、Nagai Katsunori、Shimokawa Kenichiro、Ujikawa Osamu、Fujimori Ikuo、Ito Masahiro、Hayase Youji、Okuhira Keiichiro、Shibata Norihito、Hattori Takayuki、Sameshima Tomoya、Sano Osamu、Koyama Ryokichi、Imaeda Yasuhiro、Nara Hiroshi、Cho Nobuo、Naito Mikihiko
    • Journal Title

      Journal of Biological Chemistry

      Volume: 293 Issue: 18 Pages: 6776-6790

    • DOI

      10.1074/jbc.ra117.001091

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] HOIL1 Is Essential for the Induction of Type I and III Interferons by MDA5 and Regulates Persistent Murine Norovirus Infection2018

    • Author(s)
      MacDuff Donna A.、Baldridge Megan T.、Qaqish Arwa M.、Nice Timothy J.、Darbandi Azad D.、 Hartley Victoria L.、Peterson Stefan T.、Miner Jonathan J.、Iwai Kazuhiro、Virgin Herbert W.
    • Journal Title

      Journal of Virology

      Volume: 92 Issue: 23

    • DOI

      10.1128/jvi.01368-18

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Presentation] ユビキチン依存的なプロテアソームの液-液相分離2021

    • Author(s)
      佐伯 泰、土屋 光、遠藤彬則
    • Organizer
      第94回日本生化学大会
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] Understanding the ubiquitin-proteasome system by advanced proteomics2021

    • Author(s)
      Yasushi Saeki、Hikaru Tsuchiya、Takuya Tomita、Akinori Endo
    • Organizer
      第44回日本分子生物学会年会
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] Linear ubiquitination : a new regulator of chronic inflammation and oncogenesis2021

    • Author(s)
      Iwai, K
    • Organizer
      第44日本基礎老化学会大会
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] 直鎖状ユビキチン鎖の発見とその機能2021

    • Author(s)
      岩井 一宏
    • Organizer
      第94回日本生化学会大会
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] 標的タンパク質分解薬のoverview2021

    • Author(s)
      内藤幹彦
    • Organizer
      第40回日本認知症学会学術集会
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] Development of Highly Selective Anti-Cancer Drugs by Targeted Protein Degradation2021

    • Author(s)
      内藤幹彦
    • Organizer
      第44回日本分子生物学会年会
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] SNIPERを用いたユビキチンプロテアソーム創薬2020

    • Author(s)
      内藤幹彦
    • Organizer
      第93回日本薬理学会年会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] SNIPER化合物によるケミカルプロテインノックダウン技術の開発と細胞制御2020

    • Author(s)
      内藤幹彦
    • Organizer
      日本化学会第100春期年会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] ケモテクノロジーと質量分析計を活用したユビキチンコードの解読2019

    • Author(s)
      佐伯泰、遠藤彬則、土屋 光、大竹史明
    • Organizer
      日本ケミカルバイオロジー学会 第14回年会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] ユビキチン研究の新展開―相分離から分解誘導剤まで2019

    • Author(s)
      佐伯泰
    • Organizer
      第19回 日本蛋白質科学会年会・第71回日本細胞生物学会大会 合同年次大会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] Orbitrap Fusion Lumosを使った革新的ユビキチン研究2019

    • Author(s)
      佐伯泰
    • Organizer
      サーモフィッシャーサイエンティフィック 質量分析フォーラム2019
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] プロテアソーム液滴による核内タンパク質分解2019

    • Author(s)
      佐伯泰
    • Organizer
      第92回日本生化学会大会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] ユビキチンによるタンパク質分解のしくみ:We will degrade you!2019

    • Author(s)
      佐伯泰
    • Organizer
      第9回CSJ化学フェスタ
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] MSを用いたユビキチンシグナルの網羅的解析2019

    • Author(s)
      佐伯泰
    • Organizer
      第11回 LC/MSワークショップ
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 高浸透圧ストレスによるプロテアソーム液滴形成と核内タンパク質分解2019

    • Author(s)
      佐伯泰
    • Organizer
      第14回日本臨床ストレス応答学会シンポジウム
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] Stress- and ubiquitylation-dependent phase separation of the proteasome2019

    • Author(s)
      Yasushi Saeki
    • Organizer
      42nd MBSJ Symposium
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] Hijacking IAP ubiquitin ligases by SNIPERs to induce protein degradation2019

    • Author(s)
      Mikihiko Naito
    • Organizer
      Symposium on Frontier in PROTAC Drug Discovery and Development
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 細胞内の標的タンパク質を特異的に分解するプロテインノックダウン技術の開発2019

    • Author(s)
      内藤幹彦
    • Organizer
      日本薬学会第35回創薬セミナー
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] IAPを利用して細胞内の標的タンパク質を分解するプロテインノックダウン技術の開発2019

    • Author(s)
      内藤幹彦
    • Organizer
      第28回日本Cell Death学会学術集会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 標的タンパク質を特異的に分解するハイブリッド型低分子化合物SNIPERの開発と応用2019

    • Author(s)
      内藤幹彦
    • Organizer
      第24回日本病態プロテアーゼ学会学術集会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] Induced Protein Degradation by Chimeric Small Molecules; Recent Progress and Outlook2019

    • Author(s)
      Mikihiko Naito
    • Organizer
      Targeted Protein Degradation forum in Japan
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] Hijacking IAP ubiquitin ligases by SNIPERs to induce protein degradation2019

    • Author(s)
      Mikihiko Naito
    • Organizer
      2nd Annual Targeted Protein Degradation Summit
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 細胞内の標的タンパク質を特異的に分解するプロテインノックダウン技術の開発2019

    • Author(s)
      内藤幹彦
    • Organizer
      日本再生医療
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 次世代の医薬品開発プラットフォーム技術:プロテインノックダウン法の開発2019

    • Author(s)
      内藤幹彦
    • Organizer
      東北大学大学院薬学系研究科医薬品開発研究センターキックオフシンポジウム
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] SNIPER化合物によるプロテインノックダウン2019

    • Author(s)
      内藤幹彦
    • Organizer
      第42回日本分子生物学会年会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 化合物による標的タンパク質分解技術と創薬2019

    • Author(s)
      内藤幹彦
    • Organizer
      第69回バイオインターフェイス
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 胸腺プロテアソームによるT細胞選択機構の発見とその病態生理機能解明2019

    • Author(s)
      村田茂穂
    • Organizer
      第92回日本生化学学会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] がん、免疫疾患を惹起するユビキチン・シグナリング系:ケミカルバイオロジーを用いた介入の可能性2019

    • Author(s)
      岩井一宏
    • Organizer
      第66回日本生化学会近畿支部例会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] ユビキチン研究の現況と創薬への応用2019

    • Author(s)
      岩井一宏
    • Organizer
      第21回日本応用薬理シンポジウム
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 二次構造制御を基盤としたペプチド創薬研究2019

    • Author(s)
      出水庸介
    • Organizer
      有機合成化学協会九州山口支部講演会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 創薬研究および違法薬物の規制におけるインシリコ技術の活用2019

    • Author(s)
      出水庸介
    • Organizer
      MOEフォーラム2019
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 中分子ペプチド医薬品の開発効率化に資するレギュラトリーサイエンス研究2019

    • Author(s)
      出水庸介
    • Organizer
      2019年度衛研シンポジウム
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] タンパク質化学合成を指向したチオエステル前駆体CPI(Cysteinylprolyl imide) の設計と機能評価2019

    • Author(s)
      中津幸輝、梁瀬将史、林剛介、岡本晃充
    • Organizer
      生体機能関連化学部会若手の会 第31回サマースクール
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] How cells respond to proteasome impairment2019

    • Author(s)
      Shigeo Murata
    • Organizer
      X-ZOMES Conference 2019
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] キメラ型タンパク質分解薬SNIPERの開発2019

    • Author(s)
      内藤幹彦
    • Organizer
      日本薬学会第139年会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Ub-ProT reveals global length and composition of protein ubiquitylation in cells.2018

    • Author(s)
      Yasushi Saeki
    • Organizer
      The 8th Proteasome and Autophagy Congress
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] The Cdc48-Rad23/Dsk2 Axis Contributes to K48 Ubiquitin Chain Specificity of the Proteasome.2018

    • Author(s)
      Yasushi Saeki
    • Organizer
      FASEB SRC “Ubiquitin and Cellular Regulation”
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Ubiquitin-dependent phase separation for proteasomal degradation.2018

    • Author(s)
      Yasushi Saeki
    • Organizer
      Symposium on “Proteins; from the Cradle to the Grave”
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] The NEDD4 family ubiquitin ligase ITCH regulates proteasomal degradation by seeding branched ubiquitin chains.2018

    • Author(s)
      Fumiaki Ohtake, Yasushi Saeki, and Keiji Tanaka
    • Organizer
      FASEB Conference ”Ubiquitin and cellular regulation”
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Post-translational modification code of ubiquitin in signal transduction and protein degradation2018

    • Author(s)
      Fumiaki Ohtake, Yasushi Saeki, and Keiji Tanaka
    • Organizer
      第91回日本生化学会シンポジウム「ユビキチン様タンパク質修飾系の多様な機能:分解だけじゃない、真核生物だけじゃない」
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] The ubiquitin ligases ITCH and UBR5 regulate proteasomal degradation through K48/K63 branched ubiquitin chains.2018

    • Author(s)
      Ohtake, F., Saeki, Y., and Tanaka, K.
    • Organizer
      第41回日本分子生物学会シンポジウム「ユビキチン研究の新潮流:ユビキチンコードを識る・操る」
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Role of ubiquitination in nuclear export of proteins2018

    • Author(s)
      村田茂穂
    • Organizer
      第41回日本分子生物学会シンポジウム「ユビキチン研究の新潮流:ユビキチンコードを識る・操る」
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] プロテアソーム機能低下時の細胞応答機構2018

    • Author(s)
      村田茂穂
    • Organizer
      第91回日本生化学会大会シンポジウム
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] How cells respond to proteasome impairment2018

    • Author(s)
      Shigeo Murata
    • Organizer
      8th workshop on proteasome and autophagy
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Recent Advances in Bifunctional Degrader Molecules (e.g. SNIPER) for Targeted Protein Degradation via the Ubiquitin Proteasome System; Status and Outlook2018

    • Author(s)
      Mikihiko Naito
    • Organizer
      EFMC-ISMC 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 標的タンパク質を分解するプロテインノックダウン技術の開発と創薬への応用2018

    • Author(s)
      内藤幹彦
    • Organizer
      第62回日本薬学会関東支部大会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] SNIPERによるプロテインノックダウン技術の開発2018

    • Author(s)
      内藤幹彦
    • Organizer
      理研第4回DMP創薬ワークショップ
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Development of Protein Knockdown Technology to Induce Selective Degradation of Target Proteins2018

    • Author(s)
      Mikihiko Naito
    • Organizer
      薬物動態懇話会第41回年会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 標的タンパク質を分解する新しい創薬技術、プロテインノックダウン法の開発2018

    • Author(s)
      内藤幹彦
    • Organizer
      第91回日本内分泌学会学術総会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] IAPのユビキチンリガーゼ活性を利用した標的蛋白質分解誘導剤SNIPERの開発2018

    • Author(s)
      内藤幹彦
    • Organizer
      日経バイオテクプロフェッショナルセミナー 低分子薬の新たなモダリティ:標的蛋白質分解誘導薬の最前線
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] IAPによる細胞死・細胞周期制御とIAPのユビキチンリガーゼ活性を利用したプロテインノックダウン法の開発2018

    • Author(s)
      内藤幹彦
    • Organizer
      日本がん分子標的治療学会 鶴尾隆賞 受賞講演
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] A novel strategy for destabilizion of oncogenic fusion protein BCR-ABL to inhibit the growth of chronic myelogenous leukemea2018

    • Author(s)
      Norihito Shibata, Nobumichi Ohoka, Mikihiko Naito
    • Organizer
      日本薬学会第139年会 国際創薬シンポジウム
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Remarks] 新学術領域研究「ケモテクノロジーが拓くユビキチンニューフロンティア」ホームページ

    • URL

      http://ubiquitin.jp/index.html

    • Related Report
      2021 Annual Research Report 2019 Annual Research Report
  • [Remarks] プレスリリース「液-液相分離が担う核内タンパク質分解機構の発見」

    • URL

      http://www.igakuken.or.jp/topics/2020/0205.html

    • Related Report
      2019 Annual Research Report
  • [Remarks] プレスリリース「不要なタンパク質が分解を受ける前に解きほぐされる仕組み」

    • URL

      http://www.iam.u-tokyo.ac.jp/press_release/191213/

    • Related Report
      2019 Annual Research Report
  • [Remarks] プレスリリース「サリドマイドが手足や耳に奇形を引き起こすメカニズムを解明」

    • URL

      https://www.tokyo-med.ac.jp/news/2019/1008_091559002138.html

    • Related Report
      2019 Annual Research Report
  • [Remarks] プレスリリース「異常な翻訳停滞の強制終了を試験管内で再現」

    • URL

      https://www.tohoku.ac.jp/japanese/2020/03/press20200324-04-honnyaku.html

    • Related Report
      2019 Annual Research Report
  • [Remarks] ケモテクノロジーが拓くユビキチンニューフロンティア

    • URL

      http://www.ubiquitin.jp/

    • Related Report
      2018 Annual Research Report

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Published: 2018-07-20   Modified: 2022-12-28  

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