Grant-in-Aid for Scientific Research on Innovative Areas "Totipotency" steering group

• Project Area: Program of totipotency: From decoding to designing
• Project/Area Number: 19H05749
• Research Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: Institute of Physical and Chemical Research
• Principal Investigator: 小倉 淳郎 国立研究開発法人理化学研究所, バイオリソース研究センター, 室長 (20194524)
• Co-Investigator(Kenkyū-buntansha): 伊川 正人 大阪大学, 微生物病研究所, 教授 (20304066) ; 篠原 隆司 京都大学, 医学研究科, 教授 (30322770)
• Project Period (FY): 2019-06-28 – 2024-03-31
• Project Status: Completed (Fiscal Year 2023)
• Budget Amount: ¥44,590,000 (Direct Cost: ¥34,300,000、Indirect Cost: ¥10,290,000); Fiscal Year 2023: ¥8,320,000 (Direct Cost: ¥6,400,000、Indirect Cost: ¥1,920,000); Fiscal Year 2022: ¥8,320,000 (Direct Cost: ¥6,400,000、Indirect Cost: ¥1,920,000); Fiscal Year 2021: ¥8,320,000 (Direct Cost: ¥6,400,000、Indirect Cost: ¥1,920,000); Fiscal Year 2020: ¥8,320,000 (Direct Cost: ¥6,400,000、Indirect Cost: ¥1,920,000); Fiscal Year 2019: ¥11,310,000 (Direct Cost: ¥8,700,000、Indirect Cost: ¥2,610,000)
• Keywords: 全能性 / ゲノム再プログラム化 / 核移植クローン / 受精 / 胎盤

Outline of Research at the Start

受精は、精子と卵子が一つとなり、新しい命がスタートするドラマティックなステージである。この受精を通じて精子と卵子ゲノムは再プログラム化を受け、胎盤を含めたあらゆる組織へ分化する能力、すなわち全能性を獲得する。本領域「全能性プログラム」では、全能性のメカニズムの分子基盤を解明するとともに、その制御に挑戦する。総括班は、各研究課題を有機的かつ緊密に連携させ、相乗的に研究を推進させる。その成果は論文、プレス発表、シンポジウム、ホームページ等を通じて社会へ発信する。5年後には、本領域を学際的な「全能性研究」ハブとして機能させ、新たな学術領域における国際的な地位を確立する。

Outline of Annual Research Achievements

本領域「全能性プログラム」では、関連領域の専門家が一致協力して全能性のメカニズムの分子基盤を解明し、さらに、全能性核の再構築など全能性の制御に挑戦する。領域総括班の目的は、研究成果の最大化、その成果の社会へのフィードバック、そして次世代を担う若手の育成である。この目的のために本領域の司令塔として、各研究課題を有機的かつ緊密に連携させ、相乗的に研究を推進させる。その成果は論文、プレス発表、シンポジウム、ホームページ等を通じて社会へ発信する。今年度は、以下の活動実績を達成した。
①研究集会および班会議の開催：オンラインでのみ開催が続いていた若手勉強会は、今年度は、遺伝研の島本班員および理研の新冨班員を世話人として、7月3-5日の3日間、レクトーレ湯河原にて現地開催ができた。会場を貸し切り、参加人数84名で、優秀発表賞9名を選出した。最後の若手勉強会として十分な盛り上がりを見せ、次世代の活躍へ弾みを付けた。公開シンポジウムは、今年度は。12月11-12日に東大農学部の弥生講堂で国内規模で開催した。150名の参加であった。②webセミナーの開催：HPで紹介された論文の第一著者による論文徹底解説セミナーを継続し、9回開催した。また、招待講演者のセミナーとして、4月6日にFalong Lu博士のセミナーを開催した。学会・研究会の共催として、11月2日分子生物学会、12月5日RIKEN Symposium “Architecture and Function of Biological Assemblies”、3月8-9日に有性生殖研究会を実施した。③成果の公開：論文、プレス発表、公開シンポジウム、HPを通じて広く公開した。HPでは11回の論文解説記事を掲載した。④技術支援：遺伝子改変動物作製（伊川）、顕微授精・クローン（小倉）、幹細胞樹立（篠原、岡江、大日向）などを実施した。

Research Progress Status

令和5年度が最終年度であるため、記入しない。

Strategy for Future Research Activity

令和5年度が最終年度であるため、記入しない。

Research Products

• [Int'l Joint Research] University of Hawaii/University of South Florida/Baylor College of Medicine(米国)
• [Int'l Joint Research] National Cancer Center(中国)
• [Int'l Joint Research] Teramo University(イタリア)
• [Int'l Joint Research] Max Planck Institute(ドイツ)
• [Int'l Joint Research] Institute of Molecular Genetics(チェコ)
• [Int'l Joint Research] University of South Florida/University of Hawaii/Baylor College of Medicine(米国)
• [Int'l Joint Research] Teramo University(イタリア)
• [Int'l Joint Research] Cambridge University(英国)
• [Int'l Joint Research] 浙江大学/中国科学医学院(中国)
• [Int'l Joint Research] Max Plank Institute(ドイツ)
• [Int'l Joint Research] University of Hawaii/Baylor College of Medicine/University of Texas at San Antonio(米国)
• [Int'l Joint Research] Teramo University(イタリア)
• [Int'l Joint Research] Institute of Molecular Biology, CAS(チェコ)
• [Int'l Joint Research] Deutsches Krebsforshungszentrum(ドイツ)
• [Int'l Joint Research] Nanjing Medical University(中国)
• [Int'l Joint Research] Harvard University/University of Hawaii/Baylor College of Medicine(米国)
• [Int'l Joint Research] Teramo University(イタリア)
• [Int'l Joint Research] Cambridge University(英国)
• [Int'l Joint Research] 浙江大学/中国科学医学院(中国)
• [Int'l Joint Research] Institute of Molecular Genetics(チェコ)
• [Int'l Joint Research] Harvard University/Baylor College of Medicine/Baylor College of Medicine(米国)
• [Int'l Joint Research] Teramo University(イタリア)
• [Int'l Joint Research] Institute of Molecular Genetics(チェコ)
• [Int'l Joint Research] Max Planck Institute(ドイツ)
• [Int'l Joint Research] Nazarbayev University School of Medicine(カザフスタン)
• [Journal Article] In memory of Dr. Ryuzo Yanagimachi (Yana) (1928–2023) (2024)
  • Author(s): WAKAYAMA Teruhiko、OGURA Atsuo
  • Journal Title: Journal of Reproduction and Development Volume: 70 Issue: 2 Pages: i-vi
  • DOI: 10.1262/jrd.2024-E01
  • ISSN: 0916-8818, 1348-4400
  • Peer Reviewed / Open Access
• [Journal Article] Restoration of fertility in nonablated recipient mice after spermatogonial stem cell transplantation (2024)
  • Author(s): Morimoto Hiroko、Ogonuki Narumi、Matoba Shogo、Kanatsu-Shinohara Mito、Ogura Atsuo、Shinohara Takashi
  • Journal Title: Stem Cell Reports Volume: 19 Issue: 4 Pages: 443-455
  • DOI: 10.1016/j.stemcr.2024.02.003
  • Peer Reviewed / Open Access
• [Journal Article] Glutamine protects mouse spermatogonial stem cells against NOX1-derived ROS for sustaining self-renewal division in vitro. (2023)
  • Author(s): Miyazaki T, Kanatsu-Shinohara M, Ogonuki N, Matoba S, Ogura A, Yabe-Nishimura C, Zhang H, Pommier Y, Trumpp A, Shinohara T.
  • Journal Title: Development Volume: 150 Issue: 20
  • DOI: 10.1242/dev.201157
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] A small secreted protein NICOL regulates lumicrine-mediated sperm maturation and male fertility (2023)
  • Author(s): Kiyozumi Daiji、Shimada Kentaro、Chalick Michael、Emori Chihiro、Kodani Mayo、Oura Seiya、Noda Taichi、Endo Tsutomu、Matzuk Martin M.、Wreschner Daniel H.、Ikawa Masahito
  • Journal Title: Nature Communications Volume: 14 Issue: 1 Pages: 2354-2354
  • DOI: 10.1038/s41467-023-37984-x
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Incomplete activation of<i>Alyref</i>and<i>Gabpb1</i>leads to preimplantation arrest in cloned mouse embryos (2023)
  • Author(s): Ihashi Shunya、Hamanaka Mizuto、Kaji Masaya、Mori Ryunosuke、Nishizaki Shuntaro、Mori Miki、Imasato Yuma、Inoue Kimiko、Matoba Shogo、Ogonuki Narumi、Takasu Atsushi、Nakamura Misaki、Matsumoto Kazuya、Anzai Masayuki、Ogura Atsuo、Ikawa Masahito、Miyamoto Kei
  • Journal Title: Life Science Alliance Volume: 6 Issue: 11 Pages: e202302296-e202302296
  • DOI: 10.26508/lsa.202302296
  • Peer Reviewed / Open Access
• [Journal Article] Histidine N1-position-specific methyltransferase CARNMT1 targets C3H zinc finger proteins and modulates RNA metabolism (2023)
  • Author(s): Shimazu Tadahiro、Yoshimoto Rei、Kotoshiba Kaoru、Suzuki Takehiro、Matoba Shogo、Hirose Michiko、Akakabe Mai、Sohtome Yoshihiro、Sodeoka Mikiko、Ogura Atsuo、Dohmae Naoshi、Shinkai Yoichi
  • Journal Title: Genes & Development Volume: 37 Issue: 15-16 Pages: 724-742
  • DOI: 10.1101/gad.350755.123
  • Peer Reviewed / Open Access
• [Journal Article] SINE RNA of the imprinted miRNA clusters mediates constitutive type III interferon expression and antiviral protection in hemochorial placentas (2023)
  • Author(s): Wickramage Ishani、VanWye Jeffrey、Max Klaas、Lockhart John H.、Hortu Ismet、Mong Ezinne F.、Canfield John、Lamabadu Warnakulasuriya Patabendige Hiran M.、Guzeloglu-Kayisli Ozlem、Inoue Kimiko、Ogura Atsuo、Lockwood Charles J.、Akat Kemal M.、Tuschl Thomas、Kayisli Umit A.、Totary-Jain Hana
  • Journal Title: Cell Host & Microbe Volume: 31 Issue: 7 Pages: 1185-1199.e10
  • DOI: 10.1016/j.chom.2023.05.018
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] WIN18,446 enhances spermatogonial stem cell homing and fertility after germ cell transplantation by increasing blood-testis barrier permeability (2023)
  • Author(s): Morimoto H, Kanatsu-Shinohara M, Shinohara T.
  • Journal Title: Journal of Reproduction and Development Volume: 69 Issue: 6 Pages: 347-355
  • DOI: 10.1262/jrd.2023-074
  • ISSN: 0916-8818, 1348-4400
  • Peer Reviewed / Open Access
• [Journal Article] TSKS localizes to nuage in spermatids and regulates cytoplasmic elimination during spermiation (2023)
  • Author(s): Shimada Keisuke、Park Soojin、Oura Seiya、Noda Taichi、Morohoshi Akane、Matzuk Martin M.、Ikawa Masahito
  • Journal Title: Proceedings of the National Academy of Sciences Volume: 120 Issue: 11 Pages: 1-10
  • DOI: 10.1073/pnas.2221762120
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Transcription of MERVL retrotransposons is required for preimplantation embryo development (2023)
  • Author(s): Sakashita Akihiko、Kitano Tomohiro、Ishizu Hirotsugu、Guo Youjia、Masuda Harumi、Ariura Masaru、Murano Kensaku、Siomi Haruhiko
  • Journal Title: Nature Genetics Volume: 55 Issue: 3 Pages: 484-495
  • DOI: 10.1038/s41588-023-01324-y
  • Peer Reviewed / Open Access
• [Journal Article] 1700029I15Rik orchestrates the biosynthesis of acrosomal membrane proteins required for sperm-egg interaction (2023)
  • Author(s): Lu Yonggang、Shimada Kentaro、Tang Shaogeng、Zhang Jingjing、Ogawa Yo、Noda Taichi、Shibuya Hiroki、Ikawa Masahito
  • Journal Title: Proceedings of the National Academy of Sciences Volume: 120 Issue: 8 Pages: 1-11
  • DOI: 10.1073/pnas.2207263120
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Dynamic interplay between non-coding enhancer transcription and gene activity in development (2023)
  • Author(s): Hamamoto Kota、Umemura Yusuke、Makino Shiho、Fukaya Takashi
  • Journal Title: Nature Communications Volume: 14 Issue: 1 Pages: 826-826
  • DOI: 10.1038/s41467-023-36485-1
  • Peer Reviewed / Open Access
• [Journal Article] Testis-enriched ferlin, FER1L5, is required for Ca ²⁺ -activated acrosome reaction and male fertility (2023)
  • Author(s): Morohoshi Akane、Miyata Haruhiko、Tokuhiro Keizo、Iida-Norita Rie、Noda Taichi、Fujihara Yoshitaka、Ikawa Masahito
  • Journal Title: Science Advances Volume: 9 Issue: 4
  • DOI: 10.1126/sciadv.ade7607
  • Peer Reviewed / Open Access
• [Journal Article] TDP-43 safeguards the embryo genome from L1 retrotransposition (2022)
  • Author(s): Li Ten D.、Murano Kensaku、Kitano Tomohiro、Guo Youjia、Negishi Lumi、Siomi Haruhiko
  • Journal Title: Science Advances Volume: 8 Issue: 47
  • DOI: 10.1126/sciadv.abq3806
  • Peer Reviewed / Open Access
• [Journal Article] Mod(mdg4) variants repress telomeric retrotransposon HeT-A by blocking subtelomeric enhancers (2022)
  • Author(s): Chikara Takeuchi, Moe Yokoshi, Shu Kondo, Aoi Shibuya, Kuniaki Saito, Takashi Fukaya, Haruhiko Siomi, Yuka W Iwasaki
  • Journal Title: Nucleic Acids Research Volume: 50 Issue: 20 Pages: 11580-11599
  • DOI: 10.1093/nar/gkac1034
  • Peer Reviewed / Open Access
• [Journal Article] Histone H3K36me2 and H3K36me3 form a chromatin platform essential for DNMT3A-dependent DNA methylation in mouse oocytes (2022)
  • Author(s): Yano Seiichi、Ishiuchi Takashi、Abe Shusaku、Namekawa Satoshi H.、Huang Gang、Ogawa Yoshihiro、Sasaki Hiroyuki
  • Journal Title: Nature Communications Volume: 13 Issue: 1 Pages: 4440-4440
  • DOI: 10.1038/s41467-022-32141-2
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] The microRNA cluster C19MC confers differentiation potential into trophoblast lineages upon human pluripotent stem cells (2022)
  • Author(s): Kobayashi Norio、Okae Hiroaki、Hiura Hitoshi、Kubota Naoto、Kobayashi Eri H.、Shibata Shun、Oike Akira、Hori Takeshi、Kikutake Chie、Hamada Hirotaka、Kaji Hirokazu、Suyama Mikita、Bortolin-Cavaill? Marie-Line、Cavaill? J?r?me、Arima Takahiro
  • Journal Title: Nature Communications Volume: 13 Issue: 1 Pages: 3071-3071
  • DOI: 10.1038/s41467-022-30775-w
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Birth of mice from meiotically arrested spermatocytes following biparental meiosis in halved oocytes (2022)
  • Author(s): Narumi Ogonuki, Hirohisa Kyogoku, Toshiaki Hino, Yuki Osawa, Yasuhiro Fujiwara, Kimiko Inoue, Tetsuo Kunieda, Seiya Mizuno, Hiroyuki Tateno, Fumihiro Sugiyama, Tomoya S. Kitajima, Atsuo Ogura
  • Journal Title: EMBO Rep Volume: 5;23(7) Issue: 7
  • DOI: 10.15252/embr.202254992
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Establishment of mouse stem cells that can recapitulate the developmental potential of primitive endoderm (2022)
  • Author(s): Ohinata Yasuhide、Endo Takaho A.、Sugishita Hiroki、Watanabe Takashi、Iizuka Yusuke、Kawamoto Yurie、Saraya Atsunori、Kumon Mami、Koseki Yoko、Kondo Takashi、Ohara Osamu、Koseki Haruhiko
  • Journal Title: Science Volume: 375 Issue: 6580 Pages: 574-578
  • DOI: 10.1126/science.aay3325
  • Peer Reviewed / Open Access
• [Journal Article] Dynamic modulation of enhancer responsiveness by core promoter elements in living <i>Drosophila</i> embryos (2021)
  • Author(s): Yokoshi Moe、Kawasaki Koji、Camb?n Manuel、Fukaya Takashi
  • Journal Title: Nucleic Acids Research Volume: 50 Issue: 1 Pages: 92-107
  • DOI: 10.1093/nar/gkab1177
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] The conserved fertility factor SPACA4/Bouncer has divergent modes of action in vertebrate fertilization (2021)
  • Author(s): Fujihara Yoshitaka、Herberg Sarah、Blaha Andreas、Panser Karin、Kobayashi Kiyonori、Larasati Tamara、Novatchkova Maria、Theussl Hans-Christian、Olszanska Olga、Ikawa Masahito、Pauli Andrea
  • Journal Title: Proceedings of the National Academy of Sciences Volume: 118 Issue: 39
  • DOI: 10.1073/pnas.2108777118
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Formation of spermatogonia and fertile oocytes in golden hamsters requires piRNAs (2021)
  • Author(s): Loubalova Zuzana、Fulka Helena、Horvat Filip、Pasulka Josef、Malik Radek、Hirose Michiko、Ogura Atsuo、Svoboda Petr
  • Journal Title: Nature Cell Biology Volume: 23 Issue: 9 Pages: 992-1001
  • DOI: 10.1038/s41556-021-00746-2
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Production of functional oocytes requires maternally expressed PIWI genes and piRNAs in golden hamsters (2021)
  • Author(s): Hasuwa Hidetoshi、Iwasaki Yuka W.、Au Yeung Wan Kin、Ishino Kyoko、Masuda Harumi、Sasaki Hiroyuki、Siomi Haruhiko
  • Journal Title: Nature Cell Biology Volume: 23 Issue: 9 Pages: 1002-1012
  • DOI: 10.1038/s41556-021-00745-3
  • Peer Reviewed / Open Access
• [Journal Article] RanGTP and the actin cytoskeleton keep paternal and maternal chromosomes apart during fertilization (2021)
  • Author(s): Mori Masashi、Yao Tatsuma、Mishina Tappei、Endoh Hiromi、Tanaka Masahito、Yonezawa Nao、Shimamoto Yuta、Yonemura Shigenobu、Yamagata Kazuo、Kitajima Tomoya S.、Ikawa Masahito
  • Journal Title: Journal of Cell Biology Volume: 220 Issue: 10
  • DOI: 10.1083/jcb.202012001
  • Peer Reviewed / Open Access
• [Journal Article] Piwi-piRNA complexes induce stepwise changes in nuclear architecture at target loci (2021)
  • Author(s): Iwasaki Yuka W、Sriswasdi Sira、Kinugasa Yasuha、Adachi Jun、Horikoshi Yasunori、Shibuya Aoi、Iwasaki Wataru、Tashiro Satoshi、Tomonaga Takeshi、Siomi Haruhiko
  • Journal Title: The EMBO Journal Volume: 40 Issue: 18
  • DOI: 10.15252/embj.2021108345
  • Peer Reviewed / Open Access
• [Journal Article] Guiding functions of the C-terminal domain of topoisomerase IIα advance mitotic chromosome assembly (2021)
  • Author(s): Keishi Shintomi and Tatsuya Hirano
  • Journal Title: Nature Communications Volume: - Issue: 1 Pages: 2917-2917
  • DOI: 10.1038/s41467-021-23205-w
  • Peer Reviewed / Open Access
• [Journal Article] Dynamics of the cell fate specifications during female gametophyte development in Arabidopsis (2021)
  • Author(s): Susaki Daichi、Suzuki Takamasa、Maruyama Daisuke、Ueda Minako、Higashiyama Tetsuya、Kurihara Daisuke
  • Journal Title: PLOS Biology Volume: 19 Issue: 3 Pages: 3001123-3001123
  • DOI: 10.1371/journal.pbio.3001123
  • Peer Reviewed / Open Access
• [Journal Article] H2AK119ub1 guides maternal inheritance and zygotic deposition of H3K27me3 in mouse embryos (2021)
  • Author(s): Mei Hailiang、Kozuka Chisayo、Hayashi Ryoya、Kumon Mami、Koseki Haruhiko、Inoue Azusa
  • Journal Title: Nature Genetics Volume: 53 Issue: 4 Pages: 539-550
  • DOI: 10.1038/s41588-021-00820-3
  • Peer Reviewed / Open Access
• [Journal Article] Cdc42 is required for male germline niche development in mice. (2021)
  • Author(s): Mori Y, Takashima S, Kanatsu-Shinohara M, Yi Z, Shinohara T.
  • Journal Title: Cell Rep Volume: 36 Issue: 7 Pages: 109550-109550
  • DOI: 10.1016/j.celrep.2021.109550
  • NAID: 120007141735
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] SPATA33 localizes calcineurin to the mitochondria and regulates sperm motility in mice (2021)
  • Author(s): Miyata Haruhiko、Oura Seiya、Morohoshi Akane、Shimada Keisuke、Mashiko Daisuke、Oyama Yuki、Kaneda Yuki、Matsumura Takafumi、Abbasi Ferheen、Ikawa Masahito
  • Journal Title: Proceedings of the National Academy of Sciences Volume: 118 Issue: 35 Pages: 1-9
  • DOI: 10.1073/pnas.2106673118
  • Peer Reviewed / Open Access
• [Journal Article] Reprogramming of the histone H3.3 landscape in the early mouse embryo. (2021)
  • Author(s): Ishiuchi, T., Abe, S., Inoue, K., Au Yeung, W.K., Miki, Y., Ogura, A. & Sasaki, H.
  • Journal Title: Nature Structural & Molecular Biology Volume: 28 Issue: 1 Pages: 38-49
  • DOI: 10.1038/s41594-020-00521-1
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Bi-allelic DNAH8 Variants Lead to Multiple Morphological Abnormalities of the Sperm Flagella and Primary Male Infertility (2020)
  • Author(s): Liu Chunyu、Miyata Haruhiko、Gao Yang、Sha Yanwei、Tang Shuyan、Xu Zoulan、、、Wu Huan、Dulioust Emmanuel、Tian Shixiong、Shimada Keisuke、Cong Jiangshan、、、Aminata、Zhang Feng、Ikawa Masahito
  • Journal Title: The American Journal of Human Genetics Volume: 107 Issue: 2 Pages: 330-341
  • DOI: 10.1016/j.ajhg.2020.06.004
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Zygotic Nuclear F-Actin Safeguards Embryonic Development (2020)
  • Author(s): Okuno Tomomi、Li Wayne Yang、Hatano Yu、Takasu Atsushi、Sakamoto Yuko、Yamamoto Mari、Ikeda Zenki、Shindo Taiki、Plessner Matthias、Morita Kohtaro、Matsumoto Kazuya、Yamagata Kazuo、Grosse Robert、Miyamoto Kei
  • Journal Title: Cell Reports Volume: 31 Issue: 13 Pages: 107824-107824
  • DOI: 10.1016/j.celrep.2020.107824
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] NELL2-mediated lumicrine signaling through OVCH2 is required for male fertility. Science. (2020)
  • Author(s): Kiyozumi D, Noda T, Yamaguchi R, Tobita T, Matsumura T, Shimada K, Kodani M, Kohda T, Fujihara Y, Ozawa M, Yu Z, Miklossy G, Bohren KM, Horie M, Okabe M, Matzuk MM, Ikawa M.
  • Journal Title: Science. Volume: 368 Issue: 6495 Pages: 1132-1135
  • DOI: 10.1126/science.aay5134
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Loss of H3K27me3 imprinting in the Sfmbt2 miRNA cluster causes enlargement of cloned mouse placentas (2020)
  • Author(s): Inoue Kimiko、Ogonuki Narumi、Kamimura Satoshi、Inoue Hiroki、Matoba Shogo、Hirose Michiko、Honda Arata、Miura Kento、Hada Masashi、Hasegawa Ayumi、Watanabe Naomi、Dodo Yukiko、Mochida Keiji、Ogura Atsuo
  • Journal Title: Nature Communications Volume: 11 Issue: 1 Pages: 2150-2150
  • DOI: 10.1038/s41467-020-16044-8
  • Peer Reviewed / Open Access
• [Journal Article] TESMIN, METALLOTHIONEIN-LIKE 5, is required for spermatogenesis in mice. (2020)
  • Author(s): Oji A, Isotani A, Fujihara Y, Castaneda JM, Oura S, Ikawa M.
  • Journal Title: Biology of Reproduction Volume: 102 Issue: 4 Pages: 975-983
  • DOI: 10.1093/biolre/ioaa002
  • Peer Reviewed / Open Access
• [Journal Article] Nexin-Dynein regulatory complex component DRC7 but not FBXL13 is required for sperm flagellum formation and male fertility in mice (2020)
  • Author(s): Morohoshi Akane、Miyata Haruhiko、Shimada Keisuke、Nozawa Kaori、Matsumura Takafumi、Yanase Ryuji、Shiba Kogiku、Inaba Kazuo、Ikawa Masahito
  • Journal Title: PLOS Genetics Volume: 16 Issue: 1 Pages: 1-21
  • DOI: 10.1371/journal.pgen.1008585
  • NAID: 120007159540
  • Peer Reviewed / Open Access
• [Journal Article] Genetic mutation of <i>Frem3</i> does not causeFraser syndrome in mice (2020)
  • Author(s): Kiyozumi Daiji、Mori Masashi、Kodani Mayo、Ikawa Masahito
  • Journal Title: Experimental Animals Volume: 69 Issue: 1 Pages: 104-109
  • DOI: 10.1538/expanim.19-0088
  • NAID: 130007791541
  • ISSN: 0007-5124, 1341-1357, 1881-7122
  • Peer Reviewed / Open Access
• [Journal Article] DGKγ Knock-Out Mice Show Impairments in Cerebellar Motor Coordination, LTD, and the Dendritic Development of Purkinje Cells through the Activation of PKCγ (2020)
  • Author(s): Tsumagari Ryosuke、Kakizawa Sho、Kikunaga Sakiko、Fujihara Yoshitaka、Ueda Shuji、Yamanoue Minoru、Saito Naoaki、Ikawa Masahito、Shirai Yasuhito
  • Journal Title: eneuro Volume: 7 Issue: 2 Pages: 0319-19
  • DOI: 10.1523/eneuro.0319-19.2020
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] PITHD1 is a proteasome-interacting protein essential for male fertilization (2020)
  • Author(s): Kondo Hiroyuki、Matsumura Takafumi、Kaneko Mari、Inoue Kenichi、Kosako Hidetaka、Ikawa Masahito、Takahama Yousuke、Ohigashi Izumi
  • Journal Title: Journal of Biological Chemistry Volume: 295 Issue: 6 Pages: 1658-1672
  • DOI: 10.1074/jbc.ra119.011144
  • Peer Reviewed / Open Access
• [Journal Article] IgSF11 regulates osteoclast differentiation through association with the scaffold protein PSD-95 (2020)
  • Author(s): Kim Hyunsoo、Takegahara Noriko、Walsh Matthew C.、Middleton Sarah A.、Yu Jiyeon、Shirakawa Jumpei、Ueda Jun、Fujihara Yoshitaka、Ikawa Masahito、Ishii Masaru、Kim Junhyong、Choi Yongwon
  • Journal Title: Bone Research Volume: 8 Issue: 1 Pages: 5-5
  • DOI: 10.1038/s41413-019-0080-9
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Testis‐enriched kinesin KIF9 is important for progressive motility in mouse spermatozoa (2020)
  • Author(s): Miyata Haruhiko、Shimada Keisuke、Morohoshi Akane、Oura Seiya、Matsumura Takafumi、Xu Zoulan、Oyama Yuki、Ikawa Masahito
  • Journal Title: The FASEB Journal Volume: 34 Issue: 4 Pages: 5389-5400
  • DOI: 10.1096/fj.201902755r
  • Peer Reviewed / Open Access
• [Journal Article] Identification of transmembrane protein 168 mutation in familial Brugada syndrome. (2020)
  • Author(s): Shimizu A, Zankov DP, Sato A, Komeno M, Toyoda F, Yamazaki S, Makita T, Noda T, Ikawa M, Asano Y, Miyashita Y, Takashima S, Morita H, Ishikawa T, Makita N, Hitosugi M, Matsuura H, Ohno S, Horie M, Ogita H.
  • Journal Title: FASEB Journal Volume: 34 Issue: 5 Pages: 6399-6417
  • DOI: 10.1096/fj.201902991r
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] CRISPR/Cas9-Mediated Genome Editing Reveals Oosp Family Genes are Dispensable for Female Fertility in Mice (2020)
  • Author(s): Abbasi Ferheen、Kodani Mayo、Emori Chihiro、Kiyozumi Daiji、Mori Masashi、Fujihara Yoshitaka、Ikawa Masahito
  • Journal Title: Cells Volume: 9 Issue: 4 Pages: 821-821
  • DOI: 10.3390/cells9040821
  • Peer Reviewed / Open Access
• [Journal Article] Expression and functional analyses of EPHA2 in mouse spermatogonial stem cells. (2020)
  • Author(s): Morimoto, H., Kanatsu-Shinohara, M., Orwig, K. E. and Shinohara, T.
  • Journal Title: Biol. Reprod. Volume: 102 Issue: 1 Pages: 220-232
  • DOI: 10.1093/biolre/ioz156
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Transgenesis and genome editing of mouse spermatogonial stem cells by lentivirus pseudotyped with Sendai virus F protein. (2020)
  • Author(s): Shinohara, T. and Kanatsu-Shinohara, M.
  • Journal Title: Stem Cell Reports Volume: 14 Issue: 3 Pages: 447-461
  • DOI: 10.1016/j.stemcr.2020.02.001
  • NAID: 120006936408
  • Peer Reviewed / Open Access
• [Journal Article] Acrosin is essential for sperm penetration through the zona pellucida in hamsters (2020)
  • Author(s): Hirose Michiko、Honda Arata、Fulka Helena、Tamura-Nakano Miwa、Matoba Shogo、Tomishima Toshiko、Mochida Keiji、Hasegawa Ayumi、Nagashima Kiyoshi、Inoue Kimiko、Ohtsuka Masato、Baba Tadashi、Yanagimachi Ryuzo、Ogura Atsuo
  • Journal Title: Proceedings of the National Academy of Sciences Volume: 117 Issue: 5 Pages: 2513-2518
  • DOI: 10.1073/pnas.1917595117
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Autologous transplantation of spermatogonial stem cells restores fertility in congenitally infertile mice (2020)
  • Author(s): Kanatsu-Shinohara Mito、Ogonuki Narumi、Matoba Shogo、Ogura Atsuo、Shinohara Takashi
  • Journal Title: Proceedings of the National Academy of Sciences Volume: 117 Issue: 14 Pages: 7837-7844
  • DOI: 10.1073/pnas.1914963117
  • NAID: 120006826644
  • Peer Reviewed / Open Access
• [Journal Article] Prss55 but not Prss51 is required for male fertility in mice† (2020)
  • Author(s): Kobayashi Kiyonori、Endo Tsutomu、Matsumura Takafumi、Lu Yonggang、Yu Zhifeng、Matzuk Martin M、Ikawa Masahito
  • Journal Title: Biology of Reproduction Volume: - Issue: 2 Pages: 223-234
  • DOI: 10.1093/biolre/ioaa041
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Sperm proteins SOF1, TMEM95, and SPACA6 are required for sperm－oocyte fusion in mice (2020)
  • Author(s): Taichi Noda, Yonggang Lu, Yoshitaka Fujihara, View ORCID ProfileSeiya Oura, View ORCID ProfileTakayuki Koyano, Sumire Kobayashi, Martin M. Matzuk, and View ORCID ProfileMasahito Ikawa
  • Journal Title: Proceedings of the National Academy of Sciences Volume: 117 Issue: 21 Pages: 11493-11502
  • DOI: 10.1073/pnas.1922650117
  • NAID: 120006957465
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Spermatozoa lacking Fertilization Influencing Membrane Protein (FIMP) fail to fuse with oocytes in mice (2020)
  • Author(s): Fujihara Yoshitaka、Lu Yonggang、Noda Taichi、Oji Asami、Larasati Tamara、Kojima-Kita Kanako、Yu Zhifeng、Matzuk Ryan M.、Matzuk Martin M.、Ikawa Masahito
  • Journal Title: Proceedings of the National Academy of Sciences Volume: 117 Issue: 17 Pages: 9393-9400
  • DOI: 10.1073/pnas.1917060117
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] GPAT2 is required for piRNA biogenesis, transposon silencing, and maintenance of spermatogonia in mice. (2019)
  • Author(s): Shiromoto Y, Kuramochi-Miyagawa S, Nagamori I, Chuma S, Arakawa T, Nishimura T, Hasuwa H, Tachibana T, Ikawa M, Nakano T.
  • Journal Title: Biol Reprod. Volume: Apr 5. Issue: 1 Pages: 248-256
  • DOI: 10.1093/biolre/ioz056
  • Peer Reviewed
• [Journal Article] Nine genes abundantly expressed in the epididymis are not essential for male fecundity in mice (2019)
  • Author(s): Noda T、Sakurai N、Nozawa K、Kobayashi S、Devlin D J、Matzuk M M、Ikawa M
  • Journal Title: Andrology Volume: 7 Issue: 5 Pages: 644-653
  • DOI: 10.1111/andr.12621
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Publisher Correction: Calaxin is required for cilia-driven determination of vertebrate laterality (2019)
  • Author(s): Sasaki Keita、Shiba Kogiku、Nakamura Akihiro、Kawano Natsuko、Satouh Yuhkoh、Yamaguchi Hiroshi、Morikawa Motohiro、Shibata Daisuke、Yanase Ryuji、Jokura Kei、Nomura Mami、Miyado Mami、Takada Shuji、Ueno Hironori、Nonaka Shigenori、Baba Tadashi、Ikawa Masahito、Kikkawa Masahide、Miyado Kenji、Inaba Kazuo
  • Journal Title: Communications Biology Volume: 2 Issue: 1 Pages: 1-11
  • DOI: 10.1038/s42003-019-0512-5
  • Peer Reviewed
• [Journal Article] Cutting Edge: Role of MASP-3 in the physiological activation of factor D of the alternative complement pathway (2019)
  • Author(s): Manabu Hayashi, Takeshi Machida, Yumi Ishida, Yusuke Ogata, Tomoko Omori, Mika Takasumi, Yuichi Endo, Toshiyuki Suzuki, Masayuki Sekimata, Yoshimi Homma, Masahito Ikawa, Hiromasa Ohira, Teizo Fujita, and Hideharu Sekine
  • Journal Title: The Journal of Immunology Volume: 203 Issue: 6 Pages: 1411-1416
  • DOI: 10.4049/jimmunol.1900605
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] The testis-specific serine proteases PRSS44, PRSS46, and PRSS54 are dispensable for male mouse fertility† (2019)
  • Author(s): Holcomb Richard J、Oura Seiya、Nozawa Kaori、Kent Katarzyna、Yu Zhifeng、Robertson Matthew J、Coarfa Cristian、Matzuk Martin M、Ikawa Masahito、Garcia Thomas X
  • Journal Title: Biology of Reproduction Volume: 102 Pages: 84-91
  • DOI: 10.1093/biolre/ioz158
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Identification of multiple male reproductive tract-specific proteins that regulate sperm migration through the oviduct in mice (2019)
  • Author(s): Fujihara Yoshitaka、Noda Taichi、Kobayashi Kiyonori、Oji Asami、Kobayashi Sumire、Matsumura Takafumi、Larasati Tamara、Oura Seiya、Kojima-Kita Kanako、Yu Zhifeng、Matzuk Martin M.、Ikawa Masahito
  • Journal Title: Proceedings of the National Academy of Sciences Volume: 116 Issue: 37 Pages: 18498-18506
  • DOI: 10.1073/pnas.1908736116
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Male mice, caged in the International space station for 35 days, sire healthy offspring. (2019)
  • Author(s): Matsumura T, Noda T, Muratani M, Okada R, Yamane M, Isotani A, Kudo T, Takahashi S, Ikawa M.
  • Journal Title: Scientific Research Volume: 9 Issue: 1 Pages: 13733-13733
  • DOI: 10.1038/s41598-019-50128-w
  • NAID: 120006957452
  • Peer Reviewed / Open Access
• [Journal Article] Developmental analyses of mouse embryos and adults using a non-overlapping tracing system for all three germ layers (2019)
  • Author(s): Serizawa Takashi、Isotani Ayako、Matsumura Takafumi、Nakanishi Katsuyuki、Nonaka Shigenori、Shibata Shinsuke、Ikawa Masahito、Okano Hideyuki
  • Journal Title: Development Volume: 146 Pages: 1-11
  • DOI: 10.1242/dev.174938
  • NAID: 120006957441
  • Peer Reviewed / Open Access
• [Journal Article] Polarized PtdIns(4,5)P2distribution mediated by a voltage-sensing phosphatase (VSP) regulates sperm motility (2019)
  • Author(s): Kawai Takafumi、Miyata Haruhiko、Nakanishi Hiroki、Sakata Souhei、Morioka Shin、Sasaki Junko、Watanabe Masahiko、Sakimura Kenji、Fujimoto Toyoshi、Sasaki Takehiko、Ikawa Masahito、Okamura Yasushi
  • Journal Title: Proceedings of the National Academy of Sciences Volume: 116 Issue: 51 Pages: 26020-26028
  • DOI: 10.1073/pnas.1916867116
  • Peer Reviewed / Open Access
• [Journal Article] Rap1 regulates hematopoietic stem cell survival and affects oncogenesis and response to chemotherapy (2019)
  • Author(s): Khattar E, Maung KZY, Chew CL, Ghosh A, Mok MMH, Lee P, Zhang J, Chor WHJ, Cildir G, Wang CQ, Mohd-Ismail NK, Chin DWL, Lee SC, Yang H, Shin YJ, Nam DH, Chen L, Kumar AP, Deng LW, Ikawa M, Gunaratne J, Osato M, Tergaonkar V.
  • Journal Title: Nature Communications Volume: 10 Issue: 1 Pages: 5349-5349
  • DOI: 10.1038/s41467-019-13082-9
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Mouse t-complex protein 11 is important for progressive motility in sperm† (2019)
  • Author(s): Castaneda Julio M、Miyata Haruhiko、Archambeault Denise R、Satouh Yuhkoh、Yu Zhifeng、Ikawa Masahito、Matzuk Martin M
  • Journal Title: Biology of Reproduction Volume: 102 Issue: 4 Pages: 852-862
  • DOI: 10.1093/biolre/ioz226
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Evidence for lysosomal biogenesis proteome defect and impaired autophagy in preeclampsia (2019)
  • Author(s): Nakashima Akitoshi、Cheng Shi-Bin、Ikawa Masahito、Yoshimori Tamotsu、Huber Warren J.、Menon Ramkumar、Huang Zheping、Fierce Jamie、Padbury James F.、Sadovsky Yoel、Saito Shigeru、Sharma Surendra
  • Journal Title: Autophagy Volume: 26 Issue: 10 Pages: 1-15
  • DOI: 10.1080/15548627.2019.1707494
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Aging of spermatogonial stem cells by Jnk-mediated glycolysis activation. (2019)
  • Author(s): Kanatsu-Shinohara, M., Yamamoto, T., Toh, H., Kazuki, Y., Kazuki, K., Imoto, J., Ikeo, K., Oshima, M., Shirahige, K., Iwama, A., Nabeshima, Y., Sasaki, H. and Shinohara, T.
  • Journal Title: PNAS Volume: 116 Issue: 33 Pages: 16404-16409
  • DOI: 10.1073/pnas.1904980116
  • Peer Reviewed
• [Journal Article] Birth of a marmoset following injection of elongated spermatid from a prepubertal male (2019)
  • Author(s): Ogonuki Narumi、Abe Yukiko、Kurotaki Yoko K.、Nakao Kazuki、Aiba Atsu、Sasaki Erika、Ogura Atsuo
  • Journal Title: Molecular Reproduction and Development Volume: 86 Issue: 8 Pages: 928-930
  • DOI: 10.1002/mrd.23220
  • NAID: 130007719226
  • Peer Reviewed
• [Journal Article] Dissecting the role of the germinal vesicle nuclear envelope and soluble content in the process of somatic cell remodelling and reprogramming (2019)
  • Author(s): FULKA Helena、OGURA Atsuo、LOI Pasqualino、FULKA, Jr. Josef
  • Journal Title: Journal of Reproduction and Development Volume: 65 Issue: 5 Pages: 433-441
  • DOI: 10.1262/jrd.2019-017
  • NAID: 130007732099
  • ISSN: 0916-8818, 1348-4400
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Paternal knockout of Slc38a4/SNAT4 causes placental hypoplasia associated with intrauterine growth restriction in mice (2019)
  • Author(s): Matoba Shogo、Nakamuta Shoko、Miura Kento、Hirose Michiko、Shiura Hirosuke、Kohda Takashi、Nakamuta Nobuaki、Ogura Atsuo
  • Journal Title: Proceedings of the National Academy of Sciences Volume: 116 Issue: 42 Pages: 21047-21053
  • DOI: 10.1073/pnas.1907884116
  • NAID: 130007719356
  • Peer Reviewed / Open Access
• [Journal Article] Early production of offspring by <i>in vitro</i> fertilization using first-wave spermatozoa from prepubertal male mice (2019)
  • Author(s): MOCHIDA Keiji、HASEGAWA Ayumi、OGONUKI Narumi、INOUE Kimiko、OGURA Atsuo
  • Journal Title: Journal of Reproduction and Development Volume: 65 Issue: 5 Pages: 467-473
  • DOI: 10.1262/jrd.2019-042
  • NAID: 130007732105
  • Peer Reviewed / Open Access
• [Journal Article] CRISPR/Cas9-mediated genome editing reveals 30 testis-enriched genes dispensable for male fertility in mice† (2019)
  • Author(s): Yonggang Lu, Oura Seiya, Matsumura Takafumi, et al.
  • Journal Title: Biology of Reproduction Volume: 101 Issue: 2 Pages: 501-511
  • DOI: 10.1093/biolre/ioz103
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Presentation] 柳町隆造先生のご功績について (2023)
  • Author(s): 小倉淳郎
  • Organizer: 第38回京都賞記念講演会
  • Invited
• [Presentation] What does nuclear transfer tell us about genomic reprogramming? (2023)
  • Author(s): Atsuo Ogura
  • Organizer: The 46th Annual Meeting of the Molecular Biology Society of Japan
  • Int'l Joint Research / Invited
• [Presentation] 小型実験動物の発生工学技術の開発およびその応用研究について (2023)
  • Author(s): 小倉淳郎
  • Organizer: 第45回 北海道大学獣医学学術交流基金群講演会
  • Invited
• [Presentation] 実験動物における顕微授精技術の開発ー最新の成果を中心に (2023)
  • Author(s): 小倉淳郎
  • Organizer: 第64回日本卵子学会
  • Invited
• [Presentation] Nuclear transfer for the study of the developmental epigenetics (2023)
  • Author(s): Atsuo Ogura
  • Organizer: The 36th International Mammalian Genome Conference
  • Int'l Joint Research / Invited
• [Presentation] Generation and evaluation of genetically modified marmosets for the development of disease models (2023)
  • Author(s): Erika Sasaki
  • Organizer: University of Exeter LSI seminar
  • Int'l Joint Research / Invited
• [Presentation] How to improve mouse cloning (2022)
  • Author(s): Atsuo Ogura
  • Organizer: 19th International Congress on Animal Reproduction
  • Int'l Joint Research / Invited
• [Presentation] Lumicrine Factors in the Regulation of Spermatogenesis (2022)
  • Author(s): Masahito Ikawa
  • Organizer: North American Testis workshop 2022
  • Int'l Joint Research / Invited
• [Presentation] Transposable lelements in mouse early embryos (2022)
  • Author(s): Haruhiko Siomi
  • Organizer: EMBO piRNA Workshop 2022 on PIWI proteins and piRNAs
  • Int'l Joint Research / Invited
• [Presentation] Mechanism and functions of non-canonical imprinting (2022)
  • Author(s): Azusa Inoue
  • Organizer: EMBO Workshop 2022, Molecular Mechanisms of Developmental and Regenerative Biology
  • Int'l Joint Research / Invited
• [Presentation] 精巣上体における精子成熟とその阻害剤による避妊法の開発 (2022)
  • Author(s): 伊川正人
  • Organizer: 大阪大学蛋白質研セミナー 生殖細胞・減数分裂研究の最前線
  • Invited
• [Presentation] 核移植クローンによる胎盤エピゲノムの特性解析 (2022)
  • Author(s): 小倉淳郎
  • Organizer: 大阪大学蛋白質研セミナー 生殖細胞・減数分裂研究の最前線
  • Invited
• [Presentation] 不妊症の遺伝子治療 (2022)
  • Author(s): 篠原隆司
  • Organizer: 大阪大学蛋白質研セミナー 生殖細胞・減数分裂研究の最前線
  • Invited
• [Presentation] 論文執筆・投稿からacceptまで～私の経験 (2021)
  • Author(s): 小倉淳郎
  • Organizer: 日本繁殖生物学会オンラインセミナー
  • Invited
• [Presentation] 小型実験動物を用いた受精・胚発生・胎盤発生機構の解明 (2021)
  • Author(s): 小倉淳郎
  • Organizer: 第5回HAC鹿児島
  • Invited
• [Presentation] ゲノム編集技術を用いたノックアウトハムスターの作出 (2021)
  • Author(s): 小倉淳郎
  • Organizer: 第94回日本生化学会
  • Invited
• [Presentation] IZUMO1 plays a critical role in sperm-oocyte fusion process in rat (2020)
  • Author(s): Masahito Ikawa
  • Organizer: Gordon Research Conference (Fusion)
  • Int'l Joint Research / Invited
• [Presentation] CRISPR/Cas9 Genome Editing and its Application in the Study of Fertilization (2020)
  • Author(s): Masahito Ikawa
  • Organizer: American Sociey of Andrology
  • Int'l Joint Research / Invited
• [Presentation] Recent advancements of assisted fertilization using spermatogenic cells (2020)
  • Author(s): Atsuo Ogura
  • Organizer: The 43th Annual Meeting of the Molecular Biology Society of Japan
  • Int'l Joint Research / Invited
• [Presentation] Golden hamster as a new model to study the PIWI-piRNA pathway (2020)
  • Author(s): Haruhiko Siomi
  • Organizer: Cold Spring harbor Laboratory meeting on Regulatory & Non-coding RNAs
  • Int'l Joint Research / Invited
• [Presentation] Regulation of transcriptional bursting by core promoter elements (2020)
  • Author(s): Takashi Fukaya
  • Organizer: EMBL Conference Transcription and Chromatin
  • Int'l Joint Research / Invited
• [Presentation] Biophysical approaches to elucidate the principle of spindle assembly in cell division (2020)
  • Author(s): Yuta Shimamoto
  • Organizer: Molecular Biology Society of Japan 2020 Annual Meeting
  • Int'l Joint Research / Invited
• [Presentation] What do we need for the validation of disease model marmosets? (2020)
  • Author(s): Erika Sasaki
  • Organizer: Virtual Workshop on Validation of Animal Models and Tools for Biomedical Research
  • Int'l Joint Research / Invited
• [Presentation] 実験動物を用いた生殖技術の開発とその応用 (2019)
  • Author(s): 小倉淳郎
  • Organizer: 第57回東北生殖医学会総会・学術講演会（招待講演）
  • Invited
• [Presentation] What do we learn from somatic cell nuclear transfer (SCNT)? (2019)
  • Author(s): Atsuo Ogura
  • Organizer: 42nd Annual Meeting of the Molecular Biology Society of Japan
  • Int'l Joint Research / Invited
• [Book] ゲノム編集マウスの表現型を通して推測するヒト男性不妊 実験医学 Vol.42 No.3 (2024)
  • Author(s): 伊川正人
  • Total Pages: 131
  • Publisher: 羊土社
• [Book] 不妊モデルマウスの開発と標的遺伝探索 Urology Today Vol.30, No.2 (2023)
  • Author(s): 伊川正人
  • Total Pages: 100
  • Publisher: リッチヒルメディカル
• [Book] Genome Editing in Animals (Methods and Protocols) (2023)
  • Author(s): Mitiko Hirose, Toshiko Tomishima, Atsuo Ogura
  • Total Pages: 245
  • Publisher: Springer
• [Book] 生殖医療フロントラインMOOK（2）受精とその障害 (2022)
  • Author(s): 越後貫成美、小倉淳郎
  • Total Pages: 154
  • Publisher: 中外医学社
• [Book] 別冊 医学のあゆみ ユニークな実験動物を用いた医学研究 (2022)
  • Author(s): 廣瀬 美智子、小倉 淳郎
  • Total Pages: 112
  • Publisher: 医歯薬出版株式会社
• [Book] 実験医学2021年4月号「世代を超えるエピゲノム」 (2021)
  • Author(s): 井上梓
  • Total Pages: 139
  • Publisher: 羊土社
• [Book] 実験医学別冊2021年「エピゲノムをもっと見るためのクロマチン解析実践プロトコール」 (2021)
  • Author(s): 椙下紘貴、薬師寺那由多、井上梓
  • Total Pages: 270
  • Publisher: 羊土社
• [Book] 実践 卵管学 (2020)
  • Author(s): 日野 敏昭
  • Total Pages: 414
  • Publisher: 中外医学社
• [Book] 「ゲノム編集の未来」医学のあゆみ 2020年5月30日 (2020)
  • Author(s): 野田大地，大浦聖矢，伊川正人
  • Total Pages: 232
  • Publisher: 医歯薬出版
• [Book] 繁殖生物学改訂版 (2020)
  • Author(s): 小倉淳郎ら
  • Total Pages: 368
  • Publisher: インターズー
  • ISBN: 9784866711102
• [Remarks] 全能性プログラム：デコーディングからデザインへ
  • URL: https://totipotency.biken.osaka-u.ac.jp/
• [Remarks] Program of Totipotency: From decoding to designing
  • URL: https://totipotency.biken.osaka-u.ac.jp/en
• [Remarks] Program of Totipotency: From Decoding to Designing
  • URL: https://totipotency.biken.osaka-u.ac.jp/en
• [Remarks] Program of totipotency: From decoding to designing
  • URL: https://totipotency.biken.osaka-u.ac.jp/en
• [Funded Workshop] International Symposium "Totipotency and Germ Cell Development" (2022)