Administration of the group grant "Intracellular logistics: interdisciplinary approaches to pathophysiology of membrane traffic"

• Project Area: Intracellular logistics: interdisciplinary approaches to pathophysiology of membrane traffic
• Project/Area Number: 20113001
• Research Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: Osaka University
• Principal Investigator: YOSHIMORI Tamotsu 大阪大学, 生命機能研究科, 教授 (60191649)
• Co-Investigator(Renkei-kenkyūsha): OHNO Hiroshi 独立行政法人理化学研究所, 免疫系構築研究チーム, チームリーダー (50233226) ; SASAKI Takuya 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 教授 (40241278) ; IZUMI Tetsuro 群馬大学, 生体調節研究所, 教授 (00212952) ; FUKUDA Mitsunori 東北大学, 大学院・生命科学研究科, 教授 (50311361) ; MAKINOUCHI Akitake 独立行政法人理化学研究所, 先端技術基盤部門, 部門長 (80087460) ; SHIMIZU Shiro 慶應義塾大学, 理工学部, 准教授 (30312268)
• Project Period (FY): 2008-11-13 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥87,100,000 (Direct Cost: ¥67,000,000、Indirect Cost: ¥20,100,000); Fiscal Year 2013: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2012: ¥14,820,000 (Direct Cost: ¥11,400,000、Indirect Cost: ¥3,420,000); Fiscal Year 2011: ¥9,100,000 (Direct Cost: ¥7,000,000、Indirect Cost: ¥2,100,000); Fiscal Year 2010: ¥12,090,000 (Direct Cost: ¥9,300,000、Indirect Cost: ¥2,790,000); Fiscal Year 2009: ¥9,620,000 (Direct Cost: ¥7,400,000、Indirect Cost: ¥2,220,000); Fiscal Year 2008: ¥37,570,000 (Direct Cost: ¥28,900,000、Indirect Cost: ¥8,670,000)
• Keywords: メンブレントラフィック / 細胞内輸送 / 情報科学・工学 / ケミカルバイオロジー / 分子細胞生物学 / 情報発信 / 成果報告 / 社会還元 / オルガネラ / 画像解析 / 細胞内ロジスティクス / 病態の理解 / 融合研究 / アウトリーチ / 疾患 / 情報科学 / 高次生体システム

Research Abstract

本研究は、新学術領域研究「細胞内ロジスティクス：病態の理解に向けた細胞内物流システムの融合研究」（略称：ロジスティクス）（平成20－24年度）の終了に伴い、その取りまとめを行うものである。真核細胞内の輸送システムであるメンブレントラフィックによって、細胞や組織・個体の状況に応じて在庫・輸送管理が行われる複雑な物流ネットワークが形成され、経済で言うロジスティクス＝原材料の調達から製品消費までのものの流れの総合的なマネジメントが実施されている。本領域では、この細胞内ロジスティクスが関わる病態の理解を目指し、従来の分子細胞生物学的なアプローチに加え、情報科学・工学及びケミカルバイオロジーとの融合研究を展開してきた。本申請課題の目的は、本新学術領域研究における5 年間の研究成果を取りまとめ、終了シンポジウムや報告書などとして広く公開することにより、その成果を社会に還元することにある。そのために以下を計画し、全て実施した。
１． 研究成果報告書の作成：本新学術領域研究期間中の主要な業績・成果の抜粋ならびに、論文・学会発表等をまとめた研究成果報告書を作成し、関係者に配布した。
２． 終了シンポジウムの開催：計画・公募研究者の中から特に最近優れた業績をあげている研究者を演者として、公開の終了シンポジウムを、２０１３年９月１７～１８日の２日間、兵庫県淡路島の淡路夢舞台国際会議場で開催した。８０余名の参加者を得て活発な議論が展開された。
３． 社会・国民への発信：本新学術領域研究の成果を分かり易く解説したニュースレターを印刷・発行した。また研究期間中にも行っていた重要成果の新聞などのマスメディアへの発表や、一般市民向けのセミナーを、領域で得られた成果発信のために実施した。

Current Status of Research Progress

Reason

25年度が最終年度であるため、記入しない。

Strategy for Future Research Activity

25年度が最終年度であるため、記入しない。

Research Products

• [Journal Article] Autophagy Plays a Significant Role in Determining Skin Color by Regulating Melanosome Degradation in Keratinocytes (2013)
  • Author(s): Murase D, Hachiya A, Takano K, Hicks R, Visscher MO, Kitahara T, Hase T, Takema Y, Yoshimori T
  • Journal Title: J Invest Dermatol Volume: (in press)
  • Peer Reviewed
• [Journal Article] Impaired autophagy by soluble endoglin, under physiological hypoxia in early pregnant period, is involved in poor placentation in preeclampsia (2013)
  • Author(s): Nakashima A, Yamanaka-Tatematsu M, Fujita N, Koizumi K, Shima T, Yoshida T, Nikaido T, Okamoto A, Yoshimori T, Saito S
  • Journal Title: Autophagy Volume: 9 Pages: 303-316
  • Peer Reviewed
• [Journal Article] Autophagosomes form at ER.mitochondria contact sites (2013)
  • Author(s): Hamasaki M, Furuta N, Matsuda A, Nezu A, Yamamoto A, Fujita N, Oomori H, Noda T, Haraguchi T, Hiraoka Y, Amano A, Yoshimori T
  • Journal Title: Nature Volume: 495 Issue: 7441 Pages: 389-93
  • DOI: 10.1038/nature11910
  • Peer Reviewed
• [Journal Article] Vacuolating Cytotoxin and Variants in Atg16L1 That Disrupt Autophagy Promote Helicobacter pylori Infection in Humans (2012)
  • Author(s): Raju D, Hussey S, Ang M, Terebiznik MR, Sibony M, Galindo-Mata E, Gupta V, Blanke SR, Delgado A, Romero-Gallo J, Ramjeet MS, Mascarenhas H, Peek RM, Correa P, Streutker C, Hold G, Kunstmann E, Yoshimori T, Silverberg MS, Girardin SE, Philpott DJ, El Omar E, Jones NL
  • Journal Title: Gastroenterology. Volume: 142 Issue: 5 Pages: 1160-71
  • DOI: 10.1053/j.gastro.2012.01.043
  • Peer Reviewed
• [Journal Article] Autophagy guards against Cisplatin-induced acute kidney injury (2012)
  • Author(s): Takahashi A, Kimura T, Takabatake Y, Namba T, Kaimori J, Kitamura H, Matsui I, Niimura F, Matsusaka T, Fujita N, Yoshimori T, Isaka Y, Rakugi H
  • Journal Title: Am J Pathol Volume: 180 Pages: 517-25
  • Peer Reviewed
• [Journal Article] A sensitive and quantitative technique for detecting autophagic events based on lysosomal delivery (2011)
  • Author(s): Katayama H, Kogure T, Mizushima N, Yoshimori T, Miyawaki A
  • Journal Title: Chem Biol Volume: 18 Pages: 1042-1052
  • Peer Reviewed
• [Journal Article] The LC3 recruitment mechanism is separate from Atg9L1-dependent membrane formation in the autophagic response against Salmonella (2011)
  • Author(s): Kageyama S, Omori H, Saitoh T, Sone T, Guan JL, Akira S, Imamoto F, Noda T, Yoshimori T
  • Journal Title: Mol Biol Cell Volume: 22 Pages: 2290-2300
  • Peer Reviewed
• [Journal Article] Inhibition of autophagy potentiates the antitumor effect of the multikinase inhibitor sorafenib in hepatocellular carcinoma (2011)
  • Author(s): Shimizu S, Takehara T, Hikita H, Kodama T, Tsunematsu H, Miyagi T, Hosui A, Ishida H, Tatsumi T, Kanto T, Hiramatsu N, Fujita N, Yoshimori T, Hayashi N
  • Journal Title: Int.J.Cancer Volume: 131 Issue: 3 Pages: 548-57
  • DOI: 10.1002/ijc.26374
  • Peer Reviewed
• [Journal Article] Proteome of ubiquitin/MVB pathway : possible involvement of iron-induced ubiquitylation of transferrin receptor in lysosomal degradation (2011)
  • Author(s): Tachiyama R, Ishikawa D, Matsumoto M, Nakayama KI, Yoshimori T, Yokota S, Himeno M, Tanaka Y, Fujita H
  • Journal Title: Genes Cells Volume: 16 Issue: 4 Pages: 448-66
  • DOI: 10.1111/j.1365-2443.2011.01499.x
  • Peer Reviewed
• [Journal Article] Dysfunction of autophagy participates in vacuole formation and cell death in cells replicating hepatitis C virus (2011)
  • Author(s): Taguwa S, Kambara H, Fujita N, Noda T, Yoshimori T, Koike K, Moriishi K, Matsuura Y
  • Journal Title: J Virol Volume: 85 Pages: 13185-94
  • Peer Reviewed
• [Journal Article] Atg16L2, a novel isoform of mammalian Atg16L that is not essential for canonical autophagy despite forming an Atg12-5-16L2 complex (2011)
  • Author(s): Ishibashi K, Fujita N, Kanno E, Omori H, Yoshimori T, Itoh T, Fukuda M
  • Journal Title: Autophagy Volume: 7(Epub ahead of print)
  • Peer Reviewed
• [Journal Article] Rubicon and PLEKHM1 Negatively Regulate the Endocytic/Autophagic Pathway via a Novel Rab7-binding Domain (2010)
  • Author(s): Tabata K, Matsunaga K, Sakane A, Sasaki T, Noda T, Yoshimori T
  • Journal Title: Mol Biol Cell Volume: 21 Pages: 4162-4172
  • Peer Reviewed
• [Journal Article] Autophagy requires endoplasmic reticulum targeting of the PI3-kinase complex via Atg14L (2010)
  • Author(s): Matsunaga K, Morita E, Saitoh T, Akira S, Ktistakis NT, Izumi T, Noda T, Yoshimori T
  • Journal Title: J Cell Biol Volume: 190 Pages: 511-521
  • Peer Reviewed
• [Journal Article] Combinational soluble N-ethylmaleimide-sensitive factor attachment protein receptor proteins VAMP8 and Vti1b mediate fusion of antimicrobial and canonical autophagosomes with lysosomes (2010)
  • Author(s): Furuta N, Fujita N, Noda T, Yoshimori T, Amano A
  • Journal Title: Mol Biol Cell Volume: 21 Pages: 1001-1010
  • Peer Reviewed
• [Journal Article] Modulation of Local PtdIns3P Levels by the PI Phosphatase MTMR3 Regulates Constitutive Autophagy (2010)
  • Author(s): Taguchi-Atarashi N, Hamasaki M, Matsunaga K, Omori H, Ktistakis NT, Yoshimori T, Noda T
  • Journal Title: Traffic Volume: 11 Pages: 468-478
  • Peer Reviewed
• [Journal Article] Autophagy requires endoplasmic reticulum targeting of the P13-kinase complex via Atgl4L (2010)
  • Author(s): Matsunaga K, Morita E, Saitoh T, Akira S, Ktistakis NT, Izumi T, Noda T, Yoshimori T
  • Journal Title: J Cell Biol 190 Pages: 511-521
  • Peer Reviewed
• [Journal Article] A small-molecule inhibitor shows that pirin regulatesmigration of melanoma cells (2010)
  • Author(s): Miyazaki I, Simizu S, Okumura H, Takagi S, Osada H
  • Journal Title: Nat Chem Biol 6 Pages: 667-673
  • Peer Reviewed
• [Journal Article] Autophagy requires endoplasmic reticulum targeting of the PI3-kinase complex via Atg14L. (2010)
  • Author(s): Matsunaga K, Morita E, Saitoh T, Akira S, Ktistakis NT, Izumi T, Noda, T, Yoshimori T.
  • Journal Title: J Cell Biol. Volume: 190 Pages: 511-521
  • Peer Reviewed
• [Journal Article] Rubicon and PLEKHM1 Negatively Regulate the Endocytic/Autophagic Pathway via a Novel Rab7-binding Domain. (2010)
  • Author(s): Tabata K, Matsunaga K, Sakane A, Sasaki T, Noda T, Yoshimori T.
  • Journal Title: Mol Biol Cell. Volume: 21 Pages: 4162-4172
  • Peer Reviewed
• [Journal Article] Artificial induction of autophagy around polystyrene beads in nonphagocytic cells. (2010)
  • Author(s): Kobayashi S, Kojidani T, Osakada H, Yamamoto A, Yoshimori T, Hiraoka Y, Haraguchi T.
  • Journal Title: Autophagy. 6 Pages: 36-45
  • Peer Reviewed
• [Journal Article] Modulation of local PtdIns3P levels by the P1 phosphatase MTMR3 regulates constitutive autophagy. (2010)
  • Author(s): Taguchi-Atarashi N, Hamasaki M, Matsunaga K, Omori H, Ktistakis NT, Yoshimori T, Noda T.
  • Journal Title: Traffic. 11(4) Pages: 468-478
  • Peer Reviewed
• [Journal Article] Combinational Soluble N-Ethylmaleimide-sensitive Factor Attachment Protein Receptor Proteins VAMP8 and Vtilb Mediate Fusion of Antimicrobial and Canonical Autophagosomes with Lysosomes. (2010)
  • Author(s): Furuta N, Fujita N, Noda T, Yoshimori T, Amano A.
  • Journal Title: Mol Biol Cell. 21 Pages: 1001-1010
  • Peer Reviewed
• [Journal Article] Autophagosome can support Yersinia pseudotuberculosis replication in macrophages. (2010)
  • Author(s): Moreau K, Lacas-Gervais S, Fujita N, Sebbane F, Yoshimori T, Simonet M, Lafornt F.
  • Journal Title: Cell Microbiol. (Feb 23. [Epub ahead of print])
  • Peer Reviewed
• [Journal Article] An initial step of GAS-containing autophagosome-like vacuoles formation requires Rab7 (2009)
  • Author(s): Yamaguchi H, Nakagawa I, Yamamoto A, Amano A, Noda T, Yoshimori T
  • Journal Title: PLoS Pathog Volume: 5
  • Peer Reviewed
• [Journal Article] Atg9a controls dsDNA-driven dynamic translocation of STING and the innate immune response (2009)
  • Author(s): Saitoh T§, Fujita N§, Hayashi T, Takahara K, Satoh T, Lee H, Matsunaga K, Kageyama S, Omori H, Noda T, Yamamoto N, Kawai T, Ishii K, Takeuchi O, Yoshimori T, Akira S
  • Journal Title: Proc Natl Acad Sci USA Volume: 106 Pages: 20842-20846
  • Peer Reviewed
• [Journal Article] A subdomain of the endoplasmic reticulum forms a cradle for autophagosome formation (2009)
  • Author(s): Hayashi-Nishino M, Fujita N, Noda T, Yamaguchi A, Yoshimori T, Yamamoto A
  • Journal Title: Nat Cell Biol Volume: 11 Pages: 1433-1437
  • Peer Reviewed
• [Journal Article] Differencial involvement of ATG16L1 in Crohn's disease and canonical autophagy: analysis of the organization of the ATG16L1 complex in fibroblasts (2009)
  • Author(s): Fujita N, Saitoh T, Kageyama S, Akira S, Noda T, Yoshimori T
  • Journal Title: J Biol Chem Volume: 284 Pages: 32602-32609
  • Peer Reviewed
• [Journal Article] Two Beclin-1 binding proteins, Atg14L and Rubicon, reciprocally regulate autophagy at different stages (2009)
  • Author(s): Matsunaga K, Saitoh T, Tabata K, Omori H, Satoh T, Kurotori N, Maejima I, Shirahama-Noda, K, Ichimura I, Isobe T, Akira S, Noda T, Yoshimori T
  • Journal Title: Nature Cell Biol Volume: 11 Pages: 385-396
  • Peer Reviewed
• [Journal Article] Two Beclin-1 binding proteins, Atgl4L and Rubicon, reciprocally regulate autophagy at different stages (2009)
  • Author(s): Matsunaga K, Saitoh T, Tabata K, Omori H, Satoh T, Kurotori N, Maejima I, Shirahama-Noda K, Ichimura I, Isobe T, Akira S, Noda T, Yoshimori T
  • Journal Title: Nat Cell Biol 11 Pages: 385-396
  • Peer Reviewed
• [Journal Article] Uptake via Glycoprotein 2 of FimH+ bacteria by M cells initiates mucosal immune response (2009)
  • Author(s): Hase K, Kawano K, Nochi T, Pontes GS, Fukuda S, Ebisawa M, Kadokura K, Tobe T, Fujimura Y, Kawano S, Nakato G, Kimura S, Murakami T, Iimura M, Hamura K, Fukuoka SI, Lowe AW, Waguri S, Itoh K, Kiyono H, Ohno H
  • Journal Title: Nature 462 Pages: 226-230
  • Peer Reviewed
• [Journal Article] M-Sec promotes membrane nanotube formation by interacting with Ral and the exocyst complex (2009)
  • Author(s): Hase K, Kimura S, Takatsu H, Ohmae M, Kawano S, Kitamura H, Ito M, Watarai H, Hazelet CC, Yeaman C, Ohno H
  • Journal Title: Nat Cell Biol 11 Pages: 1427-1432
  • Peer Reviewed
• [Journal Article] Two Beclin-I binding proteins, Atg14L and Rubicon, reciprocally regulate autophagy at different stages. (2009)
  • Author(s): Matsunaga K, Saitoh T, Tabata K, Ornori H, Satoh T, Kurotori N, Maejima I, Shirahama-Noda K, Ichimura I, Isobe T, Akira S, Noda T, Yoshimori T^*.
  • Journal Title: Nature Cell Biol. 11 Pages: 385-396
  • Peer Reviewed
• [Journal Article] Autophagic Elimination of Misfolded Procollagen Aggregates in the Endoplasmic Reticulum as a Means of Cell Protection. (2009)
  • Author(s): Ishida Y, Yamamoto A, Kitamura A, Lamandc S, Yoshimori T, Baternan J, Kubota H, Nagata K.
  • Journal Title: Mol Biol Cell. 20 Pages: 2744-2754
  • Peer Reviewed
• [Journal Article] Differencial involvement of ATGI6LI in Crohn's disease and canonical autophag y : analysis of the organization of the ATG 16LI complex in fibroblasts. (2009)
  • Author(s): Fujita N, Saitoh T, Kageyama S, Akira S, Noda T, Yoshimori T.
  • Journal Title: J Biol Chem. 284 Pages: 32602-32609
  • Peer Reviewed
• [Journal Article] Cochaperone activity of human butyrate-induced transcript 1 facilitates hepatitis C virus replication through an Hsp90-dependent pathway. (2009)
  • Author(s): Taguwa S, Kambara H, Omori H, Tani H, Abe T, Mori Y, Suzuki T, Yoshimori T, Moriishi K, Matsuura Y.
  • Journal Title: J Virol. 83 Pages: 10427-10436
  • Peer Reviewed
• [Journal Article] Porphyromonas gingivalis outer membrane vesicles enter human epithelial cells via an endocytic pathway and are sorted to lysosomal compartments. (2009)
  • Author(s): Furuta N, Tsuda K, Omori H, Yoshimori T, Yoshimura F, Amano A.
  • Journal Title: Infect Immnun. 77 Pages: 4187-4196
  • Peer Reviewed
• [Journal Article] The Stent-Eluting Drugs Sirolimus and Paclitaxel Suppress Healing of the Endothelium by Induction of Autophagy. (2009)
  • Author(s): Hayashi Sl, Yamamoto A, You F, Yamashita K, Ikegame Y, Tawada M, Yoshimori T, Shimizu S, Nakashima S.
  • Journal Title: Am J Pathol. 175 Pages: 2226-2234
  • Peer Reviewed
• [Journal Article] A subdomain of the endoplasmic reticulum forms a cradle for autophagosome formation. (2009)
  • Author(s): Hayashi-Nishino M, Fujita N, Noda T, Yamaguchi A, Yoshimori T, Yamamoto A.
  • Journal Title: Nat Cell Biol. 11 Pages: 1433-1437
  • Peer Reviewed
• [Journal Article] Atg9a controls dsDNA-driven dynamic translocation of STING and the innate immune response. (2009)
  • Author(s): Saitoh T, Fujita N, Hayashi T, Takahara K, Satoh T, Lee H, Matsunaga K, Kageyama S, Omori H, Noda T, Yamamoto N, Kawai T, Ishii K, Takeuchi O, Yoshimori T, Akira S. (§These authors contributed equally to this work.)
  • Journal Title: Proc Natl Acad Sci USA. 106(49) Pages: 20842-20846
  • Peer Reviewed
• [Journal Article] An initial step of GAS-containing autophagosome-like vacuoles formation requires Rab7. (2009)
  • Author(s): Yamaguchi H, Nakagawa I, Yamamoto A, Amano A, Noda T, Yoshimori T.
  • Journal Title: PLoS Pathog. 5
  • Peer Reviewed
• [Journal Article] Effect of Helicobacter pylori's vacuolating cytotoxin on the autophagy pathway in gastric epithelial cells (2009)
  • Author(s): Terebiznik MR, Raju D, Vazquez CL, Torbricki K, Kulkarni R, Blanke SR, Yoshimori T, Colombo MI, Jones NL.
  • Journal Title: Autophagy Apr 19 ; 5(3)(Epub ahead of print)
  • Peer Reviewed
• [Journal Article] Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1beta production (2008)
  • Author(s): Saitoh T§, Fujita N§, Jang MH, Uematsu S, Yang BG, Satoh T, Omori H, Noda T, Yamamoto N, Komatsu M, Tanaka K, Kawai T, Tsujimura T, Takeuchi O, Yoshimori T, Akira S
  • Journal Title: Nature Volume: 456 Pages: 264-268
  • Peer Reviewed
• [Journal Article] DAP-kinase is a mediator of endoplasmic reticulum stress-induced caspase activation and autophagic cell death (2008)
  • Author(s): Gozuacik D, Bialik S, Raveh T, Mitou G, Shohat G, Sabanay H, Mizushima N, Yoshimori T, Kimchi A
  • Journal Title: Cell Death Differ Volume: 15 Pages: 1875-1886
  • Peer Reviewed
• [Journal Article] An Atg4B Mutant Hampers the Lipidation of LC3 Paralogues and Causes Defects in Autophagosome Closure (2008)
  • Author(s): Fujita N, Hayashi M, Fukumoto H, Omori H, Yamamoto A, Noda T, Yoshimori T
  • Journal Title: Mol Biol Cell Volume: 19 Pages: 4651-4659
  • Peer Reviewed
• [Journal Article] Autophagic control of listeria through intracellular innate immune recognition in drosophila (2008)
  • Author(s): Yano T, Mita S, Ohmori H, Oshima Y, Fujimoto Y, Ueda R, Takada H, Goldman WE, Fukase K, Silverman N, Yoshimori T, Kurata S
  • Journal Title: Nat Immunol Volume: 9 Pages: 908-916
  • Peer Reviewed
• [Journal Article] The Atg16L Complex Specifies the Site of LC3 Lipidation for Membrane Biogenesis in Autophagy (2008)
  • Author(s): Fujita N, Itoh T, Fukuda M, Noda T, Yoshimori T.
  • Journal Title: Mol Biol Cell 19 Pages: 2092-2100
  • Peer Reviewed
• [Journal Article] Dynein-dependent Movement of Autophagosomes Mediates Efficient Encounters with Lysosomes (2008)
  • Author(s): Kimura S, Noda T, Yoshimori T.
  • Journal Title: Cell Struct Funct 33 Pages: 109-122
  • NAID: 130004137532
  • Peer Reviewed
• [Journal Article] Functional Analysis of α5β1 Integrin and Lipid Rafts in Invasion of Epithelial Cells by Porphyromonas gingivalis using Fluorescent Beads Coated with Bacterial Membrane Vesicle (2008)
  • Author(s): Tsuda K, Furuta N, Inaba H, Kawai S, Hanada K, Yoshimori T, Amano A.
  • Journal Title: Cell Struct Funct 33 Pages: 123-132
  • Peer Reviewed
• [Journal Article] Golgi-resident small GTPase Rab33B interacts with Atg16L and modulates autophagosome formation (2008)
  • Author(s): Itoh T, Fujita N, Kanno E, Yamamoto A, Yoshimori T, Fukuda M.
  • Journal Title: Mol. Biol Cell 19 Pages: 2916-2925
  • NAID: 120001820942
  • Peer Reviewed
• [Journal Article] Ubc4/5 and c-Cb1 Continue to Ubiquitinate EGF Receptor after Intemalization to Facilitate Polyubiquitination and Degradation (2008)
  • Author(s): Umebayashi K, Stenmark H, Yoshimori T.
  • Journal Title: Mol Biol Cell 19 Pages: 3454-3462
  • Peer Reviewed
• [Journal Article] Autophagic control of listeria through intracellular innate immune recognition in drosophila (2008)
  • Author(s): Yano T, Mita S, Ohmori H, Oshima Y, Fujimoto Y, Ueda R, Takada H, Goldman WE, Fukase K, Silverman N, Yoshimori T, Kurata S.
  • Journal Title: Nat Immunol 9 Pages: 908-916
  • Peer Reviewed
• [Journal Article] An Atg4B Mutant Hampers the Lipidation of LC3 Paralogues and Causes Defects in Autophagosome Closure (2008)
  • Author(s): Fujita N, Hayashi M, Fukumoto H, Omori H, Yamamoto A, Noda T, Yoshimori T.
  • Journal Title: Mol Biol Cell 19 Pages: 14651-4659
  • Peer Reviewed
• [Journal Article] DAP-kinase is a mediator of endoplasmic reticulum stress-induced caspase activation and autophagic cell death (2008)
  • Author(s): Gozuacik D, Bialik S, Raveh T, Mitou G, Shohat G, Sabanay H, Mizushima N, Yoshimori T, Kimchi A.
  • Journal Title: Cell Death Differ 15 Pages: 1875-1886
  • Peer Reviewed
• [Journal Article] Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1 beta production (2008)
  • Author(s): Saitoh T, Fujita N, Jang MH, Uematsu S, Yang BG, Satoh T, Omori H, Noda T, Yamamoto N, Komatsu M, Tanaka K, Kawai T, Tsujimura T, Takeuchi O, Yoshimori T, Akira S.(*These authors contributed equally to this work.)
  • Journal Title: Nature 456 Pages: 1264-268
  • Peer Reviewed
• [Journal Article] Nucleotide-Dependent Conformational Changes and Assembly of the AAA ATPase SKD1/VPS4B (2008)
  • Author(s): Inoue M, Kamikubo H, Kataoka M, Kato R, Yoshimori T, Wakatsuki S, Kawasaki M.
  • Journal Title: Traffic 9 Pages: 2180-2189
  • Peer Reviewed
• [Presentation] オートファジーの膜創成・選択性・新機能 (2013)
  • Author(s): 吉森 保
  • Organizer: 細胞内ロジスティクス・シンポジウム
  • Place of Presentation: 淡路夢舞台国際会議場
  • Invited
• [Presentation] 50 Years of Autophagy: towards Understanding The Intracellular Self-Degradation System Sustaining Life (2013)
  • Author(s): Tamotsu Yoshimori
  • Organizer: 2013 The 28th Joint Annual Conference of Biomedical Sciences
  • Place of Presentation: National Defense Medical Center(Taipei,Taiwan)
  • Invited
• [Presentation] Mechanistic Insights into Autophagy against Bacteria Invading Host Cells (2012)
  • Author(s): Tamotsu Yoshimori
  • Organizer: Cambridge Immunology Forum 2012, (Roche Distinguished Lecturer)
  • Place of Presentation: Cambridge, UK
  • Year and Date: 2012-09-20
• [Presentation] オートファジー:生命を護る細胞内大規模分解システム (2012)
  • Author(s): 吉森保
  • Organizer: 第24回気道病態研究会
  • Place of Presentation: 東京ステーションコンファレンス、東京(招待講演)
  • Year and Date: 2012-03-03
• [Presentation] Insights into Membrane Dynamics in Selective and Non-Selective Autophagy (2012)
  • Author(s): 吉森保
  • Organizer: 2012 Senri Life Science Int.Symposium on 'Cutting-edge of Autophagy Study'
  • Place of Presentation: 千里ライフサイエンスセンタービル、大阪(招待講演)
  • Year and Date: 2012-01-20
• [Presentation] Autophagy : Molecular Machinery, Membrane Dynamics, and Role in Diseases (2012)
  • Author(s): Tamotsu Yoshimori
  • Organizer: ASIシンポジウム'Frontier in Cell Biology Research'
  • Place of Presentation: The Chinese University of Hong Kong, China(招待講演)
  • Year and Date: 2012-01-04
• [Presentation] Insights into Membrane Dynamics in Mammalian Autophagy (2012)
  • Author(s): 吉森 保
  • Organizer: 第85回日本生化学会大会
  • Place of Presentation: 福岡国際会議場・マリンメッセ福岡（福岡）
  • Invited
• [Presentation] オートファジー：発見から半世紀を経て (2012)
  • Author(s): 吉森 保
  • Organizer: 第41回日本免疫学会学術集会
  • Place of Presentation: 神戸国際会議場（神戸）
  • Invited
• [Presentation] 哺乳類オートファジーの膜動態と疾患との関わり (2012)
  • Author(s): 吉森 保
  • Organizer: 第28回京都賞記念ワークショップ基礎科学部門
  • Place of Presentation: 国立京都国際会館（京都）
  • Invited
• [Presentation] Autophagy : Molecular Machinery and Role in Diseases (2012)
  • Author(s): Tamotsu Yoshimori
  • Organizer: The 12th International Symposium on Dendritic Cells
  • Place of Presentation: Convention Center EXCO(Daegu,Korea)
  • Invited
• [Presentation] Mechanistic Insights into Autophagy against Bacteria Invading Host Cells (2012)
  • Author(s): Tamotsu Yoshimori
  • Organizer: Cambridge Immunology Forum 2012
  • Place of Presentation: Peterhouse in Cambridge University(Cambridge, UK)
  • Invited
• [Presentation] New insights into selective autophagy (2012)
  • Author(s): Tamotsu Yoshimori
  • Organizer: Beatson International Cancer Conference
  • Place of Presentation: Glasgow University(Glasgow, Scotland)
  • Invited
• [Presentation] 生体防御システムとしてのオートファジー (2012)
  • Author(s): 吉森 保
  • Organizer: 第17回東京肝臓シンポジウム
  • Place of Presentation: 経団連会館（東京）
  • Invited
• [Presentation] 15 Years of Autophagy: Towards Understanding The Intracellular Self-Degradation System Sustaining Life (2012)
  • Author(s): Tamotsu Yoshimori
  • Organizer: Frontiers of Biological Sciences Seminar Series in Tsinghua University
  • Place of Presentation: 精華大学（北京、中国）
  • Invited
• [Presentation] Mechanistic insights into membrane dynamics in autophagy (2012)
  • Author(s): Tamotsu Yoshimori
  • Organizer: ASBMB 2012 Annual Meeting
  • Place of Presentation: San Diego Convention Center(San Diego ,USA)
  • Invited
• [Presentation] Autophagy : molecular machinery and role in diseases (2012)
  • Author(s): Tamotsu Yoshimori
  • Organizer: BSCB- BSDB- JSDB Joint Spring Meeting
  • Place of Presentation: University of Warwick(Coventry, UK)
  • Invited
• [Presentation] New Insights into Selective Autophagy (2011)
  • Author(s): Tamotsu Yoshimori
  • Organizer: Zing Conference on Autophagy 2011
  • Place of Presentation: Occidental Grand Xcaret, Mexico(招待講演)
  • Year and Date: 2011-12-09
• [Presentation] Autophagy : Molecular Machinery and Role in Diseases (2011)
  • Author(s): 吉森保
  • Organizer: 第27回熊本医学・生物科学シンポジウム
  • Place of Presentation: 熊本大学山崎記念館、熊本(招待講演)
  • Year and Date: 2011-11-23
• [Presentation] Autophagy : New Insights into Its Membrane Dynamics (2011)
  • Author(s): Tamotsu Yoshimori
  • Organizer: The 2^<nd> Int.Symposium on Ubiquitin and Ubiquitin-Like Modifications
  • Place of Presentation: Sinicaアカデミア生物医科学研究所、台北、台湾(招待講演)
  • Year and Date: 2011-11-11
• [Presentation] Insights into Membrane Dynamics in Autophagy (2011)
  • Author(s): Tamotsu Yoshimori
  • Organizer: EMBO Conference on Autophagy in Health and Disease in Tel Aviv
  • Place of Presentation: Israel
  • Year and Date: 2011-10-31
• [Presentation] Insights into Membrane Dynamics in Autophagy (2011)
  • Author(s): Tamotsu Yoshimori
  • Organizer: EMBO Conference on Autophagy in Health and Disease
  • Place of Presentation: Ma'ale Hachamisha Hotel, Israel(招待講演)
  • Year and Date: 2011-10-31
• [Presentation] 非選択的および選択的オートファジーにおける膜創成 (2011)
  • Author(s): 吉森保
  • Organizer: 第1回都医学研シンポジウム
  • Place of Presentation: 津田ホール、東京(招待講演)
  • Year and Date: 2011-10-27
• [Presentation] Where Does Autophagosome Come from? Membrane Biogenesis in Autophagy (2011)
  • Author(s): 吉森保
  • Organizer: 第2回日中オートファジーシンポジウム
  • Place of Presentation: 湘南国際村センター、神奈川(招待講演)
  • Year and Date: 2011-10-06
• [Presentation] Autophagosome Formation : between the ER and Mitochondria (2011)
  • Author(s): Tamotsu Yoshimori
  • Organizer: Gordon Research Conference 'Molecular Membrane Biology'
  • Place of Presentation: Proctor Academy、Andover, NH, U.S.A.(招待講演)
  • Year and Date: 2011-07-14
• [Presentation] Mechanistic Insight into Membrane Dynamics in Autophagy (2011)
  • Author(s): 吉森保
  • Organizer: 第30回内藤コンファレンス
  • Place of Presentation: シャトレーゼガトーキングダムサッポロ、北海道(招待講演)
  • Year and Date: 2011-06-30
• [Presentation] Autophagy, A Guardian of Cells against Infection (2011)
  • Author(s): Tamotsu Yoshimori
  • Organizer: The 19^<th> Federation Meeting of Korean Basic Medical Scientists
  • Place of Presentation: Grand Hilton Seoul Convention Center, Korea(招待講演)
  • Year and Date: 2011-05-13
• [Presentation] Mechanistic Insight into Membrane Dynamics in Mammalian Autophagy (2011)
  • Author(s): Tamotsu Yoshimori
  • Organizer: Keystone Symposia on Molecular and Cellular Biology "Autophagy (D1)"
  • Place of Presentation: Whistler, Canada
  • Year and Date: 2011-03-28
• [Presentation] Membrane Biogenesis in Autophagy (2011)
  • Author(s): Tamotsu Yoshimori
  • Organizer: 2011 International Symposium on Cell Signaling and Gene Regulation
  • Place of Presentation: National Cheng Kung University, Tainan, Taiwan(招待講演)
  • Year and Date: 2011-02-19
• [Presentation] 細胞の守護者・オートファジー:分子機構と疾患との関わり (2011)
  • Author(s): 吉森保
  • Organizer: 第20回癌ゲノムサイエンス研究会
  • Place of Presentation: 東京ガーデンパレス、東京(招待講演)
  • Year and Date: 2011-02-03
• [Presentation] オートファジーにおける膜創生:始まりは何処に (2011)
  • Author(s): 吉森保
  • Organizer: 第6回オートファジー研究会
  • Place of Presentation: ヤマハリゾート「つま恋」掛川、静岡県(招待講演)
  • Year and Date: 2011-01-12
• [Presentation] Mechanistic Insights into Membrane Dynamics in Autophagy (2010)
  • Author(s): Tamotsu Yoshimori
  • Organizer: 第33回日本分子生物学会年会・第83回日本生化学会大会合同大会BMB2010,Symposium 2PS12(大会長企画シンポジウム)"Expanding world of autophagy : from molecular mechanisms to pathophysiological roles"
  • Place of Presentation: 神戸ポートアイランド兵庫県(招待講演)
  • Year and Date: 2010-12-08
• [Presentation] Tuning of Membrane Dynamics in Autophagy (2010)
  • Author(s): Tamotsu Yoshimori
  • Organizer: The 1st Sino-Japan Autophagy Symposium
  • Place of Presentation: Shanxi Normal University Xian, China(招待講演)
  • Year and Date: 2010-10-16
• [Presentation] Molecular Insights into Membrane Biogenesis in Autophagy (2010)
  • Author(s): Tamotsu Yoshimori
  • Organizer: The 22nd Annual Meeting of the Korean Society for Molecular and Cellular Biology, Symposium 19 "Autophagy and Cell Death"
  • Place of Presentation: COEX Center Seoul, Korea
  • Year and Date: 2010-10-08
• [Presentation] 細胞の守護者オートファジー:分子機構と疾患における役割 (2010)
  • Author(s): 吉森保
  • Organizer: 第11回北摂循環器研究会
  • Place of Presentation: 大阪大学医学部附属病院(招待講演)
  • Year and Date: 2010-10-05
• [Presentation] オートファジーの分子機構 (2010)
  • Author(s): 吉森保
  • Organizer: 第69回日本癌学会学術総会・シンポジウムS16"がんとオートファジー"
  • Place of Presentation: 大阪国際会議場(招待講演)
  • Year and Date: 2010-09-23
• [Presentation] Mechanistic Insights into Membrane Dynamics in Autophagy (2010)
  • Author(s): Tamotsu Yoshimori
  • Organizer: The 68th Harden Conference "Autophagy : from molecules to disease"
  • Place of Presentation: Royal Agricultural College Cirencester, UK(招待講演)
  • Year and Date: 2010-09-08
• [Presentation] 細胞内世界を見る:細胞内物流システムを例に (2010)
  • Author(s): 吉森保
  • Organizer: 第13回画像の認識・理解シンポジウムMIRU2010サテライトワークショップ「細胞内画像処理」
  • Place of Presentation: 釧路市観光国際交流センター、北海道(招待講演)
  • Year and Date: 2010-07-26
• [Presentation] 細胞の守護者オートファジー:その分子機構と生理機能 (2010)
  • Author(s): 吉森保
  • Organizer: 日本がん分子標的治療学会第14回学術集会Year in Review
  • Place of Presentation: タワーホール船堀 東京
  • Year and Date: 2010-07-07
• [Presentation] 疾患に対抗する細胞機能オートファジー:分子機構、制御、生理機能 (2010)
  • Author(s): 吉森保
  • Organizer: 第6回自己免疫疾患研究会
  • Place of Presentation: 東海大学校友会館、東京(招待講演)
  • Year and Date: 2010-07-03
• [Presentation] Mechanistic insight into membrane dynamics of mammalian autophagy (2010)
  • Author(s): Tamotsu Yoshimori
  • Organizer: Gordon Research Conference "Autophagy In Stress, Development And Disease" in Lucca
  • Place of Presentation: Italy
  • Year and Date: 2010-04-27
• [Presentation] Mechanistic insight into membrane dynamics of mammalian autophagy (2010)
  • Author(s): Tamotsu Yoshimori
  • Organizer: Gordon Research Conference "Autophagy In Stress, Development And Disease"
  • Place of Presentation: Il Ciocco Hotel and Resort Lucca, Italy(招待講演)
  • Year and Date: 2010-04-27
• [Presentation] Autophagy : Intracellular Self-Degradation System Fighting with Diseases (2010)
  • Author(s): Tamotsu Yoshimori
  • Organizer: International Symposium on Organelle Network : Interface among Infection-Immunity, Cell Biology and Glycobiology
  • Place of Presentation: Senri Life Science Center Osaka(招待講演)
  • Year and Date: 2010-04-12
• [Presentation] Binding Rubicon to Cross the Rubicon (2009)
  • Author(s): Tamotsu Yoshimori
  • Organizer: EMBO Conference Series on Autophagy: Cell Biology, Physiology & Pathology in Ascona
  • Place of Presentation: Switzerland
  • Year and Date: 2009-10-19
• [Presentation] Mechanistic Insight into Membrane Dynamics in Mammalian Autophagy (2009)
  • Author(s): Tamotsu Yoshimori
  • Organizer: Gordon Research Conference "Molecular Membrane Biology" in Andover
  • Place of Presentation: NH, USA
  • Year and Date: 2009-07-09
• [Presentation] 分解系ロジスティクスの疾患における役割と作動機構 (2009)
  • Author(s): 吉森保
  • Organizer: 特定領域研究「トラフィック」終了・新学術領域研究「ロジスティクス」発足合同シンポジウム
  • Place of Presentation: 航空会館(東京)
  • Year and Date: 2009-01-29
• [Presentation] Tuning Autophagy and Heterophagy (2009)
  • Author(s): 吉森保
  • Organizer: 第61回日本細胞生物学会大会
  • Place of Presentation: 名古屋国際会議場
• [Presentation] Mechanistic Insight into Membrane Dynamics in Mammalian Autophagy (2009)
  • Author(s): Tamotsu Yoshimori
  • Organizer: Gordon Research Conference "Molecular Membrane Biology"
  • Place of Presentation: Proctor Academy, Andover, NH, USA
• [Presentation] Autophagy : Molecular Machinery and Roles in Diseases (2009)
  • Author(s): Tamotsu Yoshimori
  • Organizer: The 7th CBD(ARC Centre of Excellence in Biotechnology & Development) Scientific Meeting
  • Place of Presentation: The Country Place Retreat, Kalorama, Victoria, Australia
• [Presentation] Beclin1 Complexes, Salmonella, and Atg16L (2009)
  • Author(s): 吉森保
  • Organizer: 5th International Symposium on Autophagy
  • Place of Presentation: 大津プリンスホテル
• [Presentation] Binding Rubicon to Cross the Rubicon (2009)
  • Author(s): Tamotsu Yoshimori
  • Organizer: EMBO Conference on : Autophagy, Cell Biology, Physiology and Pathology
  • Place of Presentation: Monte Verith, Ascona, Switzerland
• [Presentation] Membrane Biogenesis and Regulatory Mechanisms in Autophagy (2009)
  • Author(s): 吉森保
  • Organizer: 第32回日本分子生物学会年会
  • Place of Presentation: パシフィコ横浜
• [Presentation] 細胞内自己消化システム・オートファジーによる生体防御 (2008)
  • Author(s): 吉森保
  • Organizer: 日本細菌学会関東支部総会特別講演
  • Place of Presentation: 生命の森リゾート(千葉)
  • Year and Date: 2008-10-24
• [Presentation] Autophagy : Molecular Machinery and Role in Cellular Defense (2008)
  • Author(s): Tamotsu Yoshimori
  • Organizer: Korean Society of Medical Biochemistry and Molecular Biology Annual International Conference : In Commemoration of the 60th KSMBMB Anniversary, Symposium SY17 : Autophagy and Human Diseases
  • Place of Presentation: Seoul, Korea
• [Presentation] Mechanistic Insight into Membrane Dynamics in Mammalian Autophagy (2008)
  • Author(s): Tamotsu Yoshimori
  • Organizer: Center for the Study of Inflammatory Bowel Disease 18th Annual Workshop on Autophagy in Immunity
  • Place of Presentation: Boston, USA
• [Presentation] Molecular Machinery of Autophagy and Its Role in Diseases (2008)
  • Author(s): Tamotsu Yoshimori
  • Organizer: 11th Western Pacific Cingress on Chemotherapy and Infectious Diseases, Symposium 9 : Invasive Group A Streptococcal Infections
  • Place of Presentation: Taipei, Taiwan
• [Presentation] Autophagy as a Cellular Defense System against Pathogens and Unfolding Proteins (2008)
  • Author(s): Tamotsu Yoshimori
  • Organizer: BMB2008(第31回日本分子生物学会年会・第81回日本生化学会大会合同大会)Symposium 3S3 : Intracellular Logistics : Approach to Pathophy siology of Membrane Traffic
  • Place of Presentation: 神戸ポーピアホテル
• [Book] Q&A / 哺乳類におけるオートファジー関連因子 オートファジー 生命をささえる細胞の自己分解システム 水島昇・吉森保 編 (2012)
  • Author(s): 吉森 保
  • Publisher: 化学同人 C1-10
• [Book] オートファジー 生命をささえる細胞の自己分解システム (2012)
  • Author(s): 吉森 保
  • Publisher: 化学同人
• [Book] Cell Imaging Techniques: Methods and Protocols Second Edition (2012)
  • Author(s): Keisuke T, Mitsuko H-N, Takeshi N, Akitsugu Y, Yoshimori T.
  • Publisher: Humana Press
• [Book] Group a streptococcus: a loser in the battle with autophagy. Beth Levine・Tamotsu Yoshimori・Vojo Deretic Editors, Curr Top Microbiol Immunol. 335 (2009)
  • Author(s): Yoshimori T, Amano A
  • Publisher: Spromger
• [Book] Monitoring autophagy in mammalian cultured cells through the dynamics of LC3. Methods Enzymol. 452 (2009)
  • Author(s): Kimura S, Fujita N, Noda T, Yoshimori T
  • Publisher: Academic Press,Inc.
• [Book] Curr Top Microbiol Immunol. 335 (2009)
  • Author(s): Yoshimori T, Amano A.
  • Publisher: Springer
• [Book] Methods Enzymol. 452 (2009)
  • Author(s): Kimura S, Fujita N, Noda T, Yoshimori T.
  • Publisher: Academic Press
• [Book] 分子細胞生物学辞典(第2版) (2008)
  • Author(s): 吉森保
  • Publisher: (株)東京化学同人
• [Remarks] 研究室HP
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