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Mammalian hibernation biology ~ survival strategies via hypometabolism and hypotherm ia

Administrative Group

Project AreaMammalian hibernation biology ~ survival strategies via hypometabolism and hypothermia
Project/Area Number 20H05765
Research Category

Grant-in-Aid for Transformative Research Areas (B)

Allocation TypeSingle-year Grants
Review Section Transformative Research Areas, Section (III)
Research InstitutionHokkaido University

Principal Investigator

Yamaguchi Yoshifumi  北海道大学, 低温科学研究所, 教授 (10447443)

Project Period (FY) 2020-10-02 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥7,670,000 (Direct Cost: ¥5,900,000、Indirect Cost: ¥1,770,000)
Fiscal Year 2022: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2021: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2020: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Keywords冬眠 / 哺乳類 / 哺乳類の冬眠 / 生理学
Outline of Research at the Start

本研究領域「冬眠生物学」では、最先端の計測技術および遺伝子工学技術を駆使した分野横断型チームにより、哺乳類生理学に残された大きな課題である「冬眠・休眠実行を担う分子ネットワークの解明」を目的とする。本領域の効果的な推進に向け、研究指針方策の検討、領域内調整による共同研究の推進、領域評価と助言、企画・広報を実行し、当該研究領域での国際的な学術連携と若手人材育成に取り組む。

Outline of Final Research Achievements

The goal of this transformative research area (B), "Hibernation and Dormancy Biology," is to elucidate the molecular networks responsible for hibernation and torpor, one of major challenges in mammalian physiology, by a cross-disciplinary team utilizing state-of-the-art measurement and genetic engineering technologies. The project leader, Dr. Yamaguchi, was responsible for the effective promotion of this research area by discussing research guidelines, promoting collaborative research through intra-regional coordination, evaluating and advising on the research area, planning and publicizing the research, and promoting international academic collaboration and fostering young researchers in this research area. We actively promoted collaboration among researchers to conduct world-class innovative research and took measures to generate synergistic effects.

Academic Significance and Societal Importance of the Research Achievements

本学術変革領域研究(B)では、冬眠動物において冬眠発動が阻害される変異体の取得に成功した。また冬眠の際に生じる低温応答、概日リズムなどの解析基盤の整備も完了した。これらの成果は、長年の謎である哺乳類の冬眠機構の解明に向けた第一歩として学術的意義が高いと言える。さらに国内関連学会でのシンポジウム企画と国際交流、冬眠研究用デバイスの改良、等で通じた知見をさらに発展させ冬眠・休眠の分子基盤に迫ることで、哺乳類の低代謝・低体温による生存戦略のより深い理解がなされるとともに、救急医療や臓器移植、低体温療法などの医学応用への礎ができると期待される。

Report

(4 results)
  • 2022 Annual Research Report   Final Research Report ( PDF )
  • 2021 Annual Research Report
  • 2020 Annual Research Report
  • Research Products

    (10 results)

All 2023 2022 2021 2020 Other

All Int'l Joint Research (1 results) Presentation (4 results) (of which Int'l Joint Research: 3 results) Book (1 results) Remarks (2 results) Funded Workshop (2 results)

  • [Int'l Joint Research] Yale University(米国)

    • Related Report
      2022 Annual Research Report
  • [Presentation] Current perspective of hibernation and torpor in mammals,2023

    • Author(s)
      Yoshifumi Yamaguchi, Takeshi Sakurai
    • Organizer
      100th Aniversary Annual Meeting of the Physiological Society of Japan, Kyoto, Japan
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 哺乳類冬眠・休眠の多面的理解2022

    • Author(s)
      山口良文、榎木亮介
    • Organizer
      第99回日本生理学会大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] Regulation of hypometabolism and hypothermia in and around hibernation2021

    • Author(s)
      Genshiro Sunagawa, Yoshifumi Yamaguchi
    • Organizer
      The 44th Annual Meeting of the Molecular biology Society of Japan
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Current perspectives on hibernation and torpor in mammals2020

    • Author(s)
      Yamaguchi Y, Sunagawa G.
    • Organizer
      The 43rd Annual Meeting of the Molecular Biology Society of Japan
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Book] 低温科学 第81巻 動物の寒冷適応戦略 生理生態と分子機構2023

    • Author(s)
      低温科学研究所編(山口良文 その他)
    • Total Pages
      205
    • Publisher
      低温科学研究所
    • Related Report
      2022 Annual Research Report
  • [Remarks] 冬眠生物学~哺乳類の低代謝・低体温による生存戦略

    • URL

      https://hibernationbiology.jp

    • Related Report
      2020 Annual Research Report
  • [Remarks] 冬眠休眠研究フォーラム

    • URL

      https://forum.hibernationbiology.jp

    • Related Report
      2020 Annual Research Report
  • [Funded Workshop] 100th Aniversary Annual Meeting of the Physiological Society of Japan2023

    • Related Report
      2022 Annual Research Report
  • [Funded Workshop] The 44th Annual Meeting of the Molecular biology Society of Japan.: Symposium "Regulation of hypometabolism and hypothermia in and around hibernation"2021

    • Related Report
      2021 Annual Research Report

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Published: 2020-10-30   Modified: 2024-01-30  

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