Integrated elucidation of inflammatory tissue-resilience and tissue damage-entropy;Creation of innovative science for resolution of inflammation

• Project Area: Integrated elucidation of inflammatory tissue-resilience and tissue damage-entropy;Creation of innovative science for resolution of inflammation
• Project/Area Number: 21H05120
• Research Category: Grant-in-Aid for Transformative Research Areas (B)
• Allocation Type: Single-year Grants
• Review Section: Transformative Research Areas, Section (III)
• Research Institution: Chiba University
• Principal Investigator: Hirahara Kiyoshi 千葉大学, 大学院医学研究院, 教授 (00707193)
• Co-Investigator(Kenkyū-buntansha): 新井 郷子 一般社団法人AIM医学研究所, 研究部門, 副所長 (60422276) ; 三上 洋平 慶應義塾大学, 医学部(信濃町), 准教授 (80528662)
• Project Period (FY): 2021-08-23 – 2024-03-31
• Project Status: Completed (Fiscal Year 2023)
• Budget Amount: ¥13,650,000 (Direct Cost: ¥10,500,000、Indirect Cost: ¥3,150,000); Fiscal Year 2023: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2022: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2021: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
• Keywords: 炎症収束 / 炎症記憶 / 炎症性組織レジリエンス / 組織障害エントロピー / 炎症性組織レンジエンス

Outline of Research at the Start

総括班の研究代表者を平原が務め、各計画研究代表者が総括班の研究分担者として、研究支援システムの整備（平原：研究班内での研究の有機的連携を行うための解析支援整備）、領域会議・国際シンポジウムの開催（新井：年1回の領域会議開催による研究成果の共有と研究班員間の共同研究に向けた有機的連携形成）、成果の発信（三上：ホームページの開設による研究成果の情報発信）をそれぞれが行う。なお、炎症領域に関わる先端的研究を行っている岩間厚志（東京大学医科学研究所）、鍋島陽一（神戸医療産業都市推進機構先端医療研究センター）、河上裕（国際医療福祉大学医学部）が研究協力者として、領域全体の評価および助言を行う。

Outline of Final Research Achievements

Aiming to understand "Inflammation Resolution”, this area has developed a research support system (Dr. Hirahara, in charge of research support), enhanced its website (Dr. Mikami, in charge of public relations), and held regular area meetings and symposia (Dr. Arai, in charge of meetings; 4 international symposia, 3 research meetings, monthly online meetings). Professor Yoichi Nabeshima (Kyoto University), Professor Yutaka Kawakami (International University of Health and Welfare, School of Medicine), and Professor Atsushi Iwama (Institute of Medical Science, University of Tokyo), who are conducting advanced research in the field of inflammation, evaluated and provided advice on the entire field.

Academic Significance and Societal Importance of the Research Achievements

これまで世界的に炎症の誘導機構については研究が盛んに行われている一方、炎症の収束機構に関する研究は注目されていなかった。本領域では、臓器や学問の従来の垣根を取り払い「炎症性組織レジリエンスと炎症の収束」に着目して統合的に研究を推進し、各班員が国際的な学術誌へ複数報告するだけでなく、「炎症収束」についての新たな概念を提示することでより大規模な新興・融合領域の形成への基盤形成を行うことができた。

Research Products

• [Int'l Joint Research] シャリテー医科大学(ドイツ)
• [Journal Article] 腎疾患におけるAIMの関与 (2024)
  • Author(s): 新井響子,宮崎徹
  • Journal Title: アニムス Volume: 118 Pages: 34-38
• [Journal Article] The USP7-STAT3-granzyme-Par-1 axis regulates allergic inflammation by promoting differentiation of IL-5-producing Th2 cells (2023)
  • Author(s): Kumagai Jin、Kiuchi Masahiro、Kokubo Kota、Yagyu Hiroyuki、Nemoto Masahiro、Tsuji Kaori、Nagahata Ken、Sasaki Atsushi、Hishiya Takahisa、Onoue Miki、Shinmi Rie、Sonobe Yuri、Iinuma Tomohisa、Yonekura Syuji、Shinga Jun、Hanazawa Toyoyuki、Koseki Haruhiko、Nakayama Toshinori、Yokote Koutaro、Hirahara Kiyoshi
  • Journal Title: Proceedings of the National Academy of Sciences Volume: 120 Issue: 49 Pages: 2302903120-2302903120
  • DOI: 10.1073/pnas.2302903120
  • Peer Reviewed / Open Access
• [Journal Article] Single-cell RNA sequencing of peripheral blood mononuclear cells from Kimura disease patient successfully treated with dupilumab (2023)
  • Author(s): Suga Kensuke、Kiuchi Masahiro、Kageyama Takahiro、Kokubo Kota、Tanaka Shigeru、Iwata Arifumi、Suzuki Kotaro、Hirahara Kiyoshi、Nakajima Hiroshi
  • Journal Title: Allergology International Volume: 72 Issue: 4 Pages: 610-613
  • DOI: 10.1016/j.alit.2023.06.002
  • ISSN: 1323-8930, 1440-1592
  • Peer Reviewed / Open Access
• [Journal Article] Differences in the expression of multidrug resistance proteins in chronic rhinosinusitis according to endotype (2023)
  • Author(s): Iinuma Tomohisa、Yonekura Syuji、Hirahara Kiyoshi、Kurita Junya、Yoneda Riyo、Arai Tomoyuki、Sonobe Yuri、Shinmi Rie、Okamoto Yoshitaka、Hanazawa Toyoyuki
  • Journal Title: Allergology International Volume: 72 Issue: 4 Pages: 564-572
  • DOI: 10.1016/j.alit.2023.03.008
  • ISSN: 1323-8930, 1440-1592
  • Peer Reviewed / Open Access
• [Journal Article] Pathogenic helper T cells as the novel therapeutic targets for immune-mediated intractable diseases (2023)
  • Author(s): Onodera Atsushi、Kokubo Kota、Okano Mikiko、Onoue Miki、Kiuchi Masahiro、Iwamura Chiaki、Iinuma Tomohisa、Kimura Motoko Y.、Ebihara Nobuyuki、Hanazawa Toyoyuki、Nakayama Toshinori、Hirahara Kiyoshi
  • Journal Title: Pharmacology & Therapeutics Volume: 247 Pages: 108445-108445
  • DOI: 10.1016/j.pharmthera.2023.108445
  • Peer Reviewed / Open Access
• [Journal Article] The roles of tertiary lymphoid structures in chronic diseases (2023)
  • Author(s): Sato Yuki、Silina Karina、van den Broek Maries、Hirahara Kiyoshi、Yanagita Motoko
  • Journal Title: Nature Reviews Nephrology Volume: 19 Issue: 8 Pages: 525-537
  • DOI: 10.1038/s41581-023-00706-z
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Apoptosis inhibitor of macrophages/CD5L enhances phagocytosis in the trabecular meshwork cells and regulates ocular hypertension (2023)
  • Author(s): Nemoto Hotaka、Honjo Megumi、Arai Satoko、Miyazaki Toru、Aihara Makoto
  • Journal Title: Journal of Cellular Physiology Volume: 238 Issue: 10 Pages: 2451-2467
  • DOI: 10.1002/jcp.31097
  • Peer Reviewed / Open Access
• [Journal Article] AIM/CD5L ameliorates autoimmune arthritis by promoting removal of inflammatory DAMPs at the lesions (2023)
  • Author(s): Yasuda Keisuke、Shimodan Shieri、Maehara Natsumi、Hirota Aika、Iijima Ruka、Nishijima Akemi、Mori Haruka、Toyama Ran、Ito Atsumi、Yoshikawa Yuri、Arai Satoko、Miyazaki Toru
  • Journal Title: Journal of Autoimmunity Volume: 142 Pages: 103149-103149
  • DOI: 10.1016/j.jaut.2023.103149
  • Peer Reviewed / Open Access
• [Journal Article] Divergent roles for STAT4 in shaping differentiation of cytotoxic ILC1 and NK cells during gut inflammation (2023)
  • Author(s): Scarno G, Mazej J, Laffranchi M, Di Censo C, Mattiola I, Candelotti AM, Pietropaolo G, Stabile H, Fionda C, Peruzzi G, Brooks SR, Tsai WL, Mikami Y, Bernardini G, Gismondi A, et al
  • Journal Title: Proceedings of the National Academy of Sciences Volume: 120(40) Issue: 40
  • DOI: 10.1073/pnas.2306761120
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Characterization of eosinophils and natural killer cells in nasal polyps and peripheral blood in eosinophilic chronic rhinosinusitis patients (2023)
  • Author(s): Tsuji Kaori、Aoki Ami、Onodera Atsushi、Kiuchi Masahiro、Kokubo Kota、Morimoto Yuki、Iinuma Tomohisa、Hanazawa Toyoyuki、Nakayama Toshinori、Hirahara Kiyoshi
  • Journal Title: Allergology International Volume: 72 Issue: 2 Pages: 335-338
  • DOI: 10.1016/j.alit.2022.11.009
  • ISSN: 1323-8930, 1440-1592
  • Peer Reviewed / Open Access
• [Journal Article] Thioredoxin-interacting protein is essential for memory T cell formation via the regulation of the redox metabolism (2023)
  • Author(s): Kokubo Kota、Hirahara Kiyoshi、Kiuchi Masahiro、Tsuji Kaori、Shimada Yuki、Sonobe Yuri、Shinmi Rie、Hishiya Takahisa、Iwamura Chiaki、Onodera Atsushi、Nakayama Toshinori
  • Journal Title: Proceedings of the National Academy of Sciences Volume: 120 Issue: 2
  • DOI: 10.1073/pnas.2218345120
  • Peer Reviewed / Open Access
• [Journal Article] Myeloid TLR4 signaling promotes post-injury withdrawal resolution of murine liver fibrosis (2023)
  • Author(s): Takimoto Yoichi、Chu Po-sung、Nakamoto Nobuhiro、Hagihara Yuya、Mikami Yohei、Miyamoto Kentaro、Morikawa Rei、Teratani Toshiaki、Taniki Nobuhito、Fujimori Sota、Suzuki Takahiro、Koda Yuzo、Ishihara Rino、Ichikawa Masataka、Honda Akira、Kanai Takanori
  • Journal Title: iScience Volume: 26 Issue: 3 Pages: 106220-106220
  • DOI: 10.1016/j.isci.2023.106220
  • Peer Reviewed / Open Access
• [Journal Article] The new preparation method for paraffin-embedded samples applying scanning electron microscopy revealed characteristic features in asthma-induced mice (2022)
  • Author(s): Wakai Ken、Azuma Kazuhiko、Iwamura Chiaki、Maimaiti Maihulan、Mikami Kosuke、Yoneda Kei、Sakamoto Shinichi、Ikehara Sanae、Yamaguchi Takashi、Hirahara Kiyoshi、Ichikawa Tomohiko、Nakayama Toshinori、Ikehara Yuzuru
  • Journal Title: Scientific Reports Volume: 12(1) Issue: 1 Pages: 9046-9046
  • DOI: 10.1038/s41598-022-12666-8
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Elevated Myl9 reflects the Myl9-containing microthrombi in SARS-CoV-2-induced lung exudative vasculitis and predicts COVID-19 severity (2022)
  • Author(s): Iwamura Chiaki、Hirahara Kiyoshi、Kiuchi Masahiro、Ikehara Sanae、Azuma Kazuhiko、Shimada Tadanaga、Kuriyama Sachiko、Ohki Syota、Yamamoto Emiri、Inaba Yosuke、Shiko Yuki、Aoki Ami、Kokubo Kota、et al.
  • Journal Title: Proceedings of the National Academy of Sciences Volume: 119 Issue: 33 Pages: 2203437119-2203437119
  • DOI: 10.1073/pnas.2203437119
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Single-cell immunoprofiling after immunotherapy for allergic rhinitis reveals functional suppression of pathogenic TH2 cells and clonal conversion (2022)
  • Author(s): Iinuma Tomohisa、Kiuchi Masahiro、Hirahara Kiyoshi、Kurita Junya、Kokubo Kota、Yagyu Hiroyuki、Yoneda Riyo、Arai Tomoyuki、Sonobe Yuri、Fukuyo Masaki、Kaneda Atsushi、Yonekura Syuji、Nakayama Toshinori、Okamoto Yoshitaka、Hanazawa Toyoyuki
  • Journal Title: Journal of Allergy and Clinical Immunology Volume: 150 Issue: 4 Pages: 850-860.e5
  • DOI: 10.1016/j.jaci.2022.06.024
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Liver group 2 innate lymphoid cells regulate blood glucose levels through IL-13 signaling and suppression of gluconeogenesis (2022)
  • Author(s): Fujimoto Masanori、Yokoyama Masataka、Kiuchi Masahiro、Hosokawa Hiroyuki、Nakayama Akitoshi、Hashimoto Naoko、Sakuma Ikki、Nagano Hidekazu、Yamagata Kazuyuki、Kudo Fujimi、Manabe Ichiro、Lee Eunyoung、Hatano Ryo、Onodera Atsushi、Hirahara Kiyoshi、Yokote Koutaro、Miki Takashi、Nakayama Toshinori、Tanaka Tomoaki
  • Journal Title: Nature Communications Volume: 13 Issue: 1 Pages: 1-21
  • DOI: 10.1038/s41467-022-33171-6
  • Peer Reviewed / Open Access
• [Journal Article] Interleukin-33-activated neuropeptide CGRP-producing memory Th2 cells cooperate with somatosensory neurons to induce conjunctival itch (2022)
  • Author(s): Okano Mikiko、Hirahara Kiyoshi、Kiuchi Masahiro、Onoue Miki、Iwamura Chiaki、Kokubo Kota、Hishiya Takahisa、Morimoto Yuki、Ikehara Yuzuru、Murakami Akira、Ebihara Nobuyuki、Nakayama Toshinori
  • Journal Title: Immunity Volume: 55 Issue: 12 Pages: 2352-2368.e7
  • DOI: 10.1016/j.immuni.2022.09.016
  • Peer Reviewed / Open Access
• [Journal Article] Conventional and pathogenic Th2 cells in inflammation, tissue repair, and fibrosis (2022)
  • Author(s): Kokubo Kota、Onodera Atsushi、Kiuchi Masahiro、Tsuji Kaori、Hirahara Kiyoshi、Nakayama Toshinori
  • Journal Title: Frontiers in Immunology Volume: 13 Pages: 945063-945063
  • DOI: 10.3389/fimmu.2022.945063
  • Peer Reviewed / Open Access
• [Journal Article] アレルギー疾患の病態形成における記憶型病原性Th2細胞の役割 (2022)
  • Author(s): 平原潔、尾上美樹、横山美樹子、中山俊憲
  • Journal Title: アレルギー Volume: 71(4) Pages: 297-300
• [Journal Article] 病原性免疫記憶による慢性炎症性肺疾患の病態形成機構 (2022)
  • Author(s): 柳生洋行、平原潔、中山俊憲
  • Journal Title: 医学のあゆみ 基盤病態としての慢性炎症 Volume: 282(1) Pages: 19-25
• [Journal Article] 局所免疫応答における組織常在性メモリーT細胞 (2022)
  • Author(s): 小久保幸太、平原潔
  • Journal Title: 臨床免疫・アレルギー科 Volume: 78(4) Pages: 438-443
• [Journal Article] CD4陽性T細胞と肺の線維化 (2022)
  • Author(s): 平原潔、小久保幸太、中山俊憲
  • Journal Title: 医学のあゆみ Volume: 283(1) Pages: 4-9
• [Journal Article] Two independent modes of kidney stone suppression achieved by AIM/CD5L and KIM-1 (2022)
  • Author(s): Matsuura Kyohei、Maehara Natsumi、Hirota Aika、Eguchi Ayaka、Yasuda Keisuke、Taniguchi Kaori、Nishijima Akemi、Matsuhashi Nobuyuki、Shiga Yoshiyuki、Ishii Rumi、Iguchi Yasuhiro、Tanabe Kazunari、Arai Satoko、Miyazaki Toru
  • Journal Title: Communications Biology Volume: 5 Issue: 1 Pages: 783-783
  • DOI: 10.1038/s42003-022-03750-w
  • Peer Reviewed / Open Access
• [Journal Article] Enrichment of type I interferon signaling in colonic group 2 innate lymphoid cells in experimental colitis (2022)
  • Author(s): Irie Emi、Ishihara Rino、Mizushima Ichiro、Hatai Shunya、Hagihara Yuya、Takada Yoshiaki、Tsunoda Junya、Iwata Kentaro、Matsubara Yuta、Yoshimatsu Yusuke、Kiyohara Hiroki、Taniki Nobuhito、Sujino Tomohisa、Takabayashi Kaoru、Hosoe Naoki、Ogata Haruhiko、Teratani Toshiaki、Nakamoto Nobuhiro、Mikami Yohei、Kanai Takanori
  • Journal Title: Frontiers in Immunology Volume: 13 Pages: 01-10
  • DOI: 10.3389/fimmu.2022.982827
  • Peer Reviewed / Open Access
• [Journal Article] Heterogeneity of ILC2s in the Intestine; Homeostasis and Pathology (2022)
  • Author(s): Sunaga Shogo、Tsunoda Junya、Teratani Toshiaki、Mikami Yohei、Kanai Takanori
  • Journal Title: Frontiers in Immunology Volume: 13
  • DOI: 10.3389/fimmu.2022.867351
  • Peer Reviewed / Open Access
• [Journal Article] Nematode ascarosides attenuate mammalian type 2 inflammatory responses (2022)
  • Author(s): Shinoda Kenta、Choe Andrea、Hirahara Kiyoshi、Kiuchi Masahiro、Kokubo Kota、Ichikawa Tomomi、Hoki Jason S.、Suzuki Akane S.、Bose Neelanjan、Appleton Judith A.、Aroian Raffi V.、Schroeder Frank C.、Sternberg Paul W.、Nakayama Toshinori
  • Journal Title: Proceedings of the National Academy of Sciences Volume: 119(9) Issue: 9
  • DOI: 10.1073/pnas.2108686119
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Organ and brain crosstalk: The liver-brain axis in gastrointestinal, liver, and pancreatic diseases (2022)
  • Author(s): Matsubara Yuta、Kiyohara Hiroki、Teratani Toshiaki、Mikami Yohei、Kanai Takanori
  • Journal Title: Neuropharmacology Volume: 205 Pages: 108915-108915
  • DOI: 10.1016/j.neuropharm.2021.108915
  • Peer Reviewed / Open Access
• [Journal Article] The Role of CD4+ Resident Memory T Cells in Local Immunity in the Mucosal Tissue - Protection Versus Pathology - (2021)
  • Author(s): Kiyoshi Hirahara、Kota Kokubo、Ami Aoki、Masahiro Kiuchi、Toshinori Nakayama
  • Journal Title: Frontiers in Immunology Volume: - Pages: 616309-616309
  • DOI: 10.3389/fimmu.2021.616309
  • Peer Reviewed / Open Access
• [Journal Article] CD4+ T cells in inflammatory diseases: pathogenic T-helper cells and the CD69-Myl9 system (2021)
  • Author(s): Nakayama Toshinori、Hirahara Kiyoshi、Kimura Motoko Y、Iwamura Chiaki、Kiuchi Masahiro、Kokubo Kota、Onodera Atsushi、Hashimoto Kahoko、Motohashi Shinichiro
  • Journal Title: International Immunology Volume: 33(12) Issue: 12 Pages: 699-704
  • DOI: 10.1093/intimm/dxab053
  • Peer Reviewed / Open Access
• [Journal Article] Trithorax複合体を構成するCxxc1はCD4+T細胞分化におけるepigenetic licensingをつかさどる (2021)
  • Author(s): 木内 政宏、平原 潔、中山 俊憲
  • Journal Title: 臨床免疫・アレルギー科 Volume: 76(6) Pages: 688-693
  • NAID: 40022755458
• [Journal Article] High salt exacerbates acute kidney injury by disturbing the activation of CD5L/apoptosis inhibitor of macrophage (AIM) protein (2021)
  • Author(s): Wang Ching-Ting、Tezuka Tetsushi、Takeda Naoki、Araki Kimi、Arai Satoko、Miyazaki Toru
  • Journal Title: PLOS ONE Volume: 16(11) Issue: 11 Pages: e0260449-e0260449
  • DOI: 10.1371/journal.pone.0260449
  • Peer Reviewed / Open Access
• [Journal Article] 肝臓-脳-腸神経連関を介した新規腸管免疫制御機構の検討 (2021)
  • Author(s): 寺谷 俊昭, 三上 洋平, 金井 隆典
  • Journal Title: 潰瘍 Volume: 48 Pages: 27-31
• [Journal Article] 【脳とからだ】腸,免疫系,脳の相互作用 迷走神経を介した新しい炎症抑制メカニズム (2021)
  • Author(s): 寺谷 俊昭, 三上 洋平, 金井 隆典
  • Journal Title: 生体の科学 Volume: 72 Pages: 401-404
• [Journal Article] 【自然リンパ球と制御性T細胞の新知見】「腸→肝臓→脳→腸相関による迷走神経反射」が腸管制御性T細胞量を調整 (2021)
  • Author(s): 寺谷 俊昭, 三上 洋平, 金井 隆典
  • Journal Title: 臨床免疫・アレルギー科 Volume: 75 Pages: 233-237
• [Journal Article] 【大腸癌のスクリーニングとサーベイランスの標準化に向けて-新しい知見から】サーベイランス 潰瘍性大腸炎関連腫瘍のサーベイランス 診療のポイントと最近のトピックス (2021)
  • Author(s): 牟田口 真, 岩男 泰, 下田 将之, 南木 康作, 三上 洋平, 筋野 智久, 高林 馨, 緒方 晴彦, 金井 隆典
  • Journal Title: Intestine Volume: 25 Pages: 108-114
• [Presentation] “神経-免疫連関”と慢性炎症の病態形成 - 病原性CD4+ T (pathogenic T: Tpath)細胞による病的な痒みの誘導機構 (2024)
  • Author(s): 平原潔
  • Organizer: シンポジウム 第101回日本生理学会大会
  • Invited
• [Presentation] 「組織炎症記憶」の蓄積がもたらす慢性炎症の難治化とその制御」 (2024)
  • Author(s): 平原潔
  • Organizer: 第2回STROMA (Stromal cell neTwork in chROnic inflamMAtion and disease)
  • Invited
• [Presentation] 慢性炎症下における病原性記憶T細胞を起点とした難治性病態形成の分子・細胞機構 (2024)
  • Author(s): 平原潔
  • Organizer: 第48回皮膚科免疫セミナー
  • Invited
• [Presentation] Pathological tissue inflammatory memories shape the intractable pathology of chronic lung inflammation (2024)
  • Author(s): Hirahara, K
  • Organizer: 10th Global Network Forum on Infection and Immunity
  • Invited
• [Presentation] Development of next-generation mucosal vaccines by controlling “pathogenic” immune memory (2024)
  • Author(s): Hirahara, K
  • Organizer: (Lecture) Dr. Toshinori Nakayama Memorial cMAV-cSIMVa Workshop
  • Invited
• [Presentation] A novel subpopulation of fibroblasts involved in the formation of inducible bronchus-associated lymphoid tissue (iBALT) (2024)
  • Author(s): Hishiya, T., Kiuchi, M., Nakayama, T., Ohotori, S., and Hirahara, K
  • Organizer: Dr. Toshinori Nakayama Memorial cMAV-cSIMVa Workshop
• [Presentation] Physiological acid exposure in the esophagus activates esophageal immune system (2024)
  • Author(s): Kurosugi, A., Iwamura, C., Kaneko, T., and Hirahara, K
  • Organizer: Dr. Toshinori Nakayama Memorial cMAV-cSIMVa Workshop
• [Presentation] The effect of tissue hypoxia on the immune system in chronic inflammation (2024)
  • Author(s): Sasaki, A., Kiuchi, M., Yagyu, H., Suzuki, T., Nakayama, T., and Hirahara, K
  • Organizer: Dr. Toshinori Nakayama Memorial cMAV-cSIMVa Workshop
• [Presentation] Repetitive exposure to aspergillus antigen induces type 17 inflammation accompanied by alveolar epithelial cell differentiation (2024)
  • Author(s): Tsuji, K., Aoki, A., Kiuchi, M., Nemoto, M., Nakayama, T., and Hirahara, K
  • Organizer: Dr. Toshinori Nakayama Memorial cMAV-cSIMVa Workshop
• [Presentation] Diverse characteristics of pulmonary neuroendocrine cells reversed in chronic airway inflammation (2024)
  • Author(s): Nemoto, M., Kiuchi, M., Tsuji, K., Nakayama, T., and Hirahara, K
  • Organizer: Dr. Toshinori Nakayama Memorial cMAV-cSIMVa Workshop
• [Presentation] Lipolysis-microlipophagy cascade regulated by adipose triglyceride lipase drives pathogenic type 2 adaptive immunity via the PPARg-ST2 axis (2024)
  • Author(s): Yagyu, H., Kiuchi, M., Kokubo, K., Sasaki, A., Onodera, A., Iwamura, C., Kaneko, T., Nakayama, T., and Hirahara, K
  • Organizer: Dr. Toshinori Nakayama Memorial cMAV-cSIMVa Workshop
• [Presentation] The USP7-STAT3-granzyme-Par-1 axis regulates allergic inflammation by promoting differentiation of IL-5-producing Th2 cells (2024)
  • Author(s): Kumagai,J., Kiuchi, M., Kokubo, K., Yagyu, H., Nemoto, M., Tsuji. K., Nagahata, K., Sasaki, A., Hishiya, T., Onoue, M., Shinmi, R., Sonobe, Y., Iinuma, T., Yonekura, S., Shinga, J., Hanazawa, T., Koseki, H., Nakayama, T., Yokote, K., and Hirahara, K
  • Organizer: Dr. Toshinori Nakayama Memorial cMAV-cSIMVa Workshop
• [Presentation] Inflammation driven fibrosis and tissue repair (2024)
  • Author(s): Hirahara, K
  • Organizer: (Overview talk) The 52nd Annual Meeting of The Japanese Society for Immunology
  • Int'l Joint Research / Invited
• [Presentation] Memory-type pathogenic Th2 (Tpath2) cells in airway inflammation (2024)
  • Author(s): Hirahara, K., and Nakayama, T
  • Organizer: (Symposium) The 52nd Annual Meeting of The Japanese Society for Immunology
  • Int'l Joint Research / Invited
• [Presentation] Inflamed tissue-derived unsaturated fatty acids induce memory-type pathogenic Th2 cells via the PPARg-ST2 axis (2024)
  • Author(s): Yagyu, H., Kiuchi, M., Kokubo, K., Sasaki, A., Kaneko, T., Nakayama, T., and Hirahara, K
  • Organizer: The 52nd Annual Meeting of The Japanese Society for Immunology
  • Int'l Joint Research
• [Presentation] A novel subpopulation of fibroblasts involved in the formation of induciblebronchus-associated lymphoid tissue (iBALT) (2024)
  • Author(s): Hishiya, T., Kiuchi, M., Nakayama, T., and Hirahara, K
  • Organizer: The 52nd Annual Meeting of The Japanese Society for Immunology
  • Int'l Joint Research
• [Presentation] Thioredoxin-interacting protein is essential for memory T cell formation via the regulation of the redox metabolism (2024)
  • Author(s): Kokubo, K., Hirahara, K., Kiuchi, M., Tsuji, K., Sonobe, Y., Shinmi, R., Hishiya, T., Iwamura, C., Onodera, A., and Nakayama, T
  • Organizer: The 52nd Annual Meeting of The Japanese Society for Immunology
  • Int'l Joint Research
• [Presentation] Diverse characteristics of pulmonary neuroendocrine cells revealed in chronic airway inflammation (2024)
  • Author(s): Nemoto, M., Kiuchi, M., Tsuji, K., Nakayama, T., and Hirahara, K
  • Organizer: The 52nd Annual Meeting of The Japanese Society for Immunology
  • Int'l Joint Research
• [Presentation] The USP7-STAT3-granzyme-Par-1 axis regulates allergic inflammation by promoting differentiation of IL-5-producing Th2 cells (2024)
  • Author(s): Kiuchi, M., Kokubo, K., Yagyu, H., Nemoto, M., Tsuji, K., Hishiya, T., Onoue, M., Shinmi, R., Sonobe, Y., Nakayama, T., and Hirahara, K
  • Organizer: The 52nd Annual Meeting of The Japanese Society for Immunology
  • Int'l Joint Research
• [Presentation] Characterization of eosinophils and natural killer cells in nasal polyps and peripheral blood in eosinophilic chronic rhinosinusitis patients (2024)
  • Author(s): Tsuji, K., Aoki, A., Onodera, A., Kiuchi, M., Kokubo, K., Morimoto, Y., Iinuma, T., Hanazawa, T., Nakayama, T., and Hirahara, K
  • Organizer: The 52nd Annual Meeting of The Japanese Society for Immunology
  • Int'l Joint Research
• [Presentation] Suppression of type I interferon signaling in myeloid cells by autoantibodies in severe COVID-19 patients (2024)
  • Author(s): Sasaki, A., Aoki, A., Iwamura, C., Kiuchi, M., Tsuji, K., Hishiya, T., Hirasawa, R., Kokubo, K., Onodera, A., Suzuki, T., Nakayama, T., and Hirahara, K
  • Organizer: The 52nd Annual Meeting of The Japanese Society for Immunology
  • Int'l Joint Research
• [Presentation] Amphiregulin-producing T helper 2 cells facilitate esophageal fibrosis of eosinophilic esophagitis (2024)
  • Author(s): Kaneko, T., Iwamura, C., Kurosugi, A., Kiuchi, M., Nakayama, T., and Hirahara, K
  • Organizer: The 52nd Annual Meeting of The Japanese Society for Immunology
  • Int'l Joint Research
• [Presentation] Pathological tissue inflammatory memories (2024)
  • Author(s): Hirahara, K
  • Organizer: 5th CSI/JSI/KAI Joint Symposium on Immunology “Frontier in Immunology Research in the Aftermath of the Pandemic”
  • Int'l Joint Research / Invited
• [Presentation] Thioredoxin-interacting protein is essential for memory T cell formation via the regulation of the redox metabolism (2024)
  • Author(s): Kokubo, K., Kiuchi, M., Hirahara, K., and Nakayama, T
  • Organizer: 5th CSI/JSI/KAI Joint Symposium on Immunology “Frontier in Immunology Research in the Aftermath of the Pandemic”
  • Int'l Joint Research
• [Presentation] IgM-mediated modulation of AIM: Enhancing clearance of biological waste (2024)
  • Author(s): Satoko Arai
  • Organizer: The International Symposium on Resolution of Inflammation
• [Presentation] 慢性アレルギー炎症難治化における病原性T細胞を中心とした細胞間ネットワークの役割 (2023)
  • Author(s): 平原潔
  • Organizer: セッション 第10回JCRベーシックリサーチカンファレンス
  • Invited
• [Presentation] 喘息病態におけるTertiary Lymphoid Structureの病的役割-治療ターゲットとしての組織炎症記憶- (2023)
  • Author(s): 平原潔
  • Organizer: Scientific Exchange Meeting in Kyoto
  • Invited
• [Presentation] 記憶T細胞を起点とした「神経免疫連関」による病的かゆみの病態形成機構 (2023)
  • Author(s): 平原潔
  • Organizer: シンポジウム 第96回日本生化学会大会
  • Invited
• [Presentation] Pathological tissue inflammatory memories - Immune-neuro interaction shapes the transformation of inflamed tissue - (2023)
  • Author(s): Hirahara, K
  • Organizer: The 32nd Hot Spring Harbor International Symposium Recent Advances in Cell Biology and Immunology 2023
  • Invited
• [Presentation] 眼瞼結膜における「神経-免疫連関」を介したかゆみの病態形成機構 (2023)
  • Author(s): 平原潔
  • Organizer: 第72回日本アレルギー学会学術大会
  • Invited
• [Presentation] 治療学研究へのいざない - SARS-CoV2感染の重症化機構から慢性炎症疾患の難治性病態まで- (2023)
  • Author(s): 平原潔
  • Organizer: 石巻赤十字病院 感染症セミナー
  • Invited
• [Presentation] 組織炎症記憶による慢性炎症の病態形成機構 (2023)
  • Author(s): 平原潔
  • Organizer: シンポジウム 第53回日本腎臓学会西部学術大会
  • Invited
• [Presentation] 病原性記憶T細胞の多様性とアレルギー性炎症の難治性病態について－組織線維化から病的かゆみまで－ (2023)
  • Author(s): 平原潔
  • Organizer: 特別公演 Online Science Club
  • Invited
• [Presentation] 疫細胞の組織への常在化と慢性炎症の難治化－組織常在性記憶T細胞と異所性リンパ組織の病的役割－ (2023)
  • Author(s): 平原潔
  • Organizer: 講演 第49回佐島シンポジウム
  • Invited
• [Presentation] 病原性T細胞と異所性リンパ組織の相互作用による病態形成機構について (2023)
  • Author(s): 平原潔
  • Organizer: シンポジウム 第4回日本喘息学会総会学術大会
  • Invited
• [Presentation] 「治療学研究へのいざない - 病原性T細胞の機能的多様性が誘導する様々な難治病態 -」 (2023)
  • Author(s): 平原潔
  • Organizer: 特別講演 第71回文月会 総会/講演会/懇親会
  • Invited
• [Presentation] 慢性炎症難治化における細胞間ネットワーク－病原性T細胞と好酸球のcross-talkによる組織線維化機構－ (2023)
  • Author(s): 平原潔
  • Organizer: 溜池カンファレンス2023
  • Invited
• [Presentation] 『治療学研究へのいざない - 病原性T細胞の機能的多様性が誘導する様々な難治病態 - 』 (2023)
  • Author(s): 平原潔
  • Organizer: 特別講演 第113回新潟内分泌代謝同好会
  • Invited
• [Presentation] COVID-19における血管内皮障害・血小板活性化のメカニズム (2023)
  • Author(s): 平原潔
  • Organizer: 第65回日本小児神経学会
  • Invited
• [Presentation] ST2+ memory Th2 cells shape the intractable pathogenesis of chronic inflammation - Interleukin-33-neuropeptide CGRP axis induces conjunctival itch - (2023)
  • Author(s): Hirahara, K
  • Organizer: The Laboratory of Immunology Weekly Seminar Series
  • Invited
• [Presentation] Immune-neuro interaction shapes the pathology of intractable allergic diseases (2023)
  • Author(s): Hirahara, K
  • Organizer: シンポジウム International Symposium for Future Mucosal Vaccines: Safeguards and Innovations against Infectious Diseases
  • Invited
• [Presentation] AIM/CD5L分子表面ネガティブ・チャージ・クラスターの機能解析 (2023)
  • Author(s): 石井和浩, 新井郷子, 宮崎徹
  • Organizer: ポスターセッション 第46回日本分子生物学会年会
• [Presentation] Facilitation of disease repair through phagocytic removal of different inflammatory organic wastes by AIM/CD5L (2023)
  • Author(s): Toru Miyazaki, Satoko Arai
  • Organizer: Poster Presentation IUIS 2023, 18th International Congress of Immunology
  • Int'l Joint Research
• [Presentation] 血中タンパク質AIMの炎症性疾患における役割とその治療・診断応用 (2023)
  • Author(s): 新井郷子
  • Organizer: 第96回日本生化学会大会
• [Presentation] 腎結石症改善に向けた最新知見 －血中タンパク質AIMの結石抑制における新たな役割の発見－ (2023)
  • Author(s): 新井郷子
  • Organizer: 第14回日本臨床一般検査学会、第20回スキルアップ講習会
• [Presentation] Facilitation of disease repair through phagocytic removal of different inflammatory elements by AIM/CD5L (2023)
  • Author(s): Toru Miyazaki, Satoko Arai
  • Organizer: 3rd RESOLUTION DAYS
  • Int'l Joint Research
• [Presentation] 炎症収束学・その先へ: 慢性炎症と炎症性組織修復レジリエンスの統合的理解 多様性から迫る腸管恒常性維持機構と炎症性腸疾患病態の理解 (2023)
  • Author(s): 三上 洋平, 佐藤 俊朗, 金井 隆典
  • Organizer: シンポジウム 第96回日本生化学会大会
• [Presentation] IBDのTreat to Targetの実際-治療選択のポイント 潰瘍性大腸炎に対する抗TNF-α抗体製剤セカンドラインの有効性に関する検討 (2023)
  • Author(s): 清原 裕貴, 三上 洋平, 金井 隆典
  • Organizer: パネルディスカッション JDDW 2023 (Japan Digestive Disease Week 2023) KOBE
• [Presentation] 疾患層別化、治療応用につながる免疫疾患の病態理解 1細胞遺伝子発現解析を用いた消化管線維芽細胞の多様性の理解 (2023)
  • Author(s): 三上 洋平, 高田 祐明, 萩原 裕也, 角田 潤也, 水島 一郎, 入江 江美, 石原 利乃, 佐藤 俊朗, 金井 隆典
  • Organizer: シンポジウム 第51回日本臨床免疫学会総会
  • Invited
• [Presentation] １細胞遺伝子発現解析を用いた消化管の機能解析 (2023)
  • Author(s): 三上洋平，高田祐明，岩田賢太郎，入江江美，角田潤哉，水島一郎，萩原裕也，石原利乃，金井隆典
  • Organizer: ワークショップ 第60回日本消化器免疫学会総会
• [Presentation] Assessment of mucosal inflammation for Crohn’s disease: safety and potential of intraoperative complete enteroscopy (ICE) (2023)
  • Author(s): Yohei MIKAMI, Koji OKABAYASHI, Takanori KANAI
  • Organizer: パネルディスカッション・国際セッション 第105回日本消化器内視鏡学会総会
  • Int'l Joint Research
• [Presentation] Enrichement of type I interferon signalling in the colonic ILC2 under inflammatory condition (2023)
  • Author(s): Yohei Mikami, Emi Irie, Rino Ishihara, Ichiro Mizushima, Takanori Kanai
  • Organizer: Poster Presentation IMMUNOLOGY2023 AAI Annual Meeting
  • Int'l Joint Research
• [Presentation] 慢性炎症難治化における細胞間ネットワーク －病原性T細胞と好酸球のcross-talkによる組織線維化機構－ (2023)
  • Author(s): 平原潔
  • Organizer: 講演 Mepolizumab Severe Asthma National Conference in Tokyo
  • Invited
• [Presentation] 病原性T細胞とアレルギー（アドバンス） (2023)
  • Author(s): 平原潔
  • Organizer: 講演 第9回総合アレルギー講習会-Total Allergistをめざして-
  • Invited
• [Presentation] Development of next-generation mucosal vaccines free from adverse reaction by controlling “pathogenic” immune memory (2023)
  • Author(s): Hirahara, K.
  • Organizer: cSIMVa Workshop
  • Int'l Joint Research / Invited
• [Presentation] The effect of tissue hypoxia on the immune system in chronic inflammatory lung diseases Presenter. International Symposium for Future Mucosal Vaccines (2023)
  • Author(s): Sasaki, A., Kiuchi, M., Yagyu, H., Tsuji, K., Suzuki, T., Nakayama, T., and Hirahara, K.
  • Organizer: Safeguards and Innovations against Infectious Diseases
  • Int'l Joint Research
• [Presentation] Expanding Pulmonary Neuroendocrine Cells Show Heterogeneity in Chronic Airway Inflammation (2023)
  • Author(s): Nemoto, M., Kiuchi, M., Tsuji, K., Nakayama, T., and Hirahara, K.
  • Organizer: International Symposium for Future Mucosal Vaccines: Safeguards and Innovations against Infectious Diseases
  • Int'l Joint Research
• [Presentation] Unsaturated fatty acids promote pathogenic type 2 adaptive immunity via PPARg-ST2 axis (2023)
  • Author(s): Yagyu, H., Kiuchi, M., Kokubo, K., Sasaki, A., Onodera, A., Iwamura, C., Kaneko, T., Nakayama T., and Hirahara, K.
  • Organizer: International Symposium for Future Mucosal Vaccines: Safeguards and Innovations against Infectious Diseases
  • Int'l Joint Research
• [Presentation] Roles of TET and TDG in DNA demethylation in the immune system (2023)
  • Author(s): Onodera, A., Tanaka, H., Hirahara, K., Nakayama, T., and Rao, A
  • Organizer: International Symposium for Future Mucosal Vaccines: Safeguards and Innovations against Infectious Diseases
  • Int'l Joint Research
• [Presentation] Role of amphiregulin-producing pathogenic T helper 2 cells in the fibrotic responses in eosinophilic esophagitis (2023)
  • Author(s): Kaneko, T., Iwamura, C., Kiuchi, M., Kurosugi, A., Hirahara, K., and Nakayama, T.
  • Organizer: International Symposium for Future Mucosal Vaccines: Safeguards and Innovations against Infectious Diseases
  • Int'l Joint Research
• [Presentation] 血中タンパク質AIMを用いた難治性慢性疾患に対する治療的・診断的応用 (2023)
  • Author(s): 新井郷子
  • Organizer: 日本生理学会 第100回記念大会
• [Presentation] 研究者の夢と目覚め ～血中タンパク質AIMの臨床応用をめざして～ (2023)
  • Author(s): 新井郷子
  • Organizer: ダイバーシティ研究環境実現イニシアティブ（先端型）第3回オープンイノベーション講演会
  • Invited
• [Presentation] 腸管FOXP3+制御性T細胞の維持を介した大腸の免疫学的恒常性における非対称的迷走神経制御機構 (2023)
  • Author(s): 三上洋平
  • Organizer: 日本生理学会第100回記念大会,
  • Invited
• [Presentation] 慢性炎症肺におけるinflammatory nicheを介した難治性病態形成機構 (2022)
  • Author(s): 平原潔
  • Organizer: シンポジウム 第62回日本呼吸器学会学術講演会
  • Invited
• [Presentation] 病原性Th2 (pathogenic Th2; Tpath2)細胞の生体内における多様な役割 (2022)
  • Author(s): 平原潔
  • Organizer: シンポジウム 第50回日本臨床免疫学会総会
  • Invited
• [Presentation] 気管支喘息と好塩基球 (2022)
  • Author(s): 平原潔
  • Organizer: 第40回呼吸器・免疫シンポジウム
  • Invited
• [Presentation] Pathological inflammatory memories (2022)
  • Author(s): 平原潔
  • Organizer: リエゾンラボ研究会 HIGOプログラム最先端研究セミナー
  • Invited
• [Presentation] 病原性Th2(pathogenic Th2;Tpath2)細胞による細胞外マトリックス沈着誘導を介した気道線維化の発症メカニズム (2022)
  • Author(s): 平原潔
  • Organizer: シンポジウム 第95回日本生化学会大会
  • Invited
• [Presentation] 病原性CD4 T細胞の多様性に基づいたアレルギー疾患の難治性病態形成機構の理解 (2022)
  • Author(s): 平原潔
  • Organizer: 特別講演 第11回神奈川気道炎症病態研究会
  • Invited
• [Presentation] 「若手研究者による破壊的イノベーションの創出」-若手研究者支援制度である創発的研究支援事業について考える- Creation of Disruptive Innovation by Young Researchers by FOREST, a long-term support system for young researchers (2022)
  • Author(s): 岡崎朋彦、平原潔
  • Organizer: フォーラム 第45回日本分子生物学会年会
  • Invited
• [Presentation] 治療学研究へのいざない - 病原性T細胞の機能的多様性と難治性病態 - (2022)
  • Author(s): 平原潔
  • Organizer: 講演 新潟大学医学部 第二内科同窓会 集談会
  • Invited
• [Presentation] Pathological inflammatory memories - Immune-neuro interaction shapes the transformation of inflamed tissue - (2022)
  • Author(s): Hirahara, K.
  • Organizer: シンポジウム 第51回日本免疫学会学術集会
  • Int'l Joint Research / Invited
• [Presentation] Multiple inflammatory cytokines shape the pathogenicity of memory CD4+ T cells during chronic allergic inflammation (2022)
  • Author(s): Hirahara, K.
  • Organizer: 第51回日本免疫学会学術集会Clinical Seminar 12
  • Int'l Joint Research / Invited
• [Presentation] Elevated Myl9 reflects the Myl9-containing microthrombi in SARS-CoV-2-induced lung exudative vasculitis and predicts COVID-19 severity (2022)
  • Author(s): Iwamura, C., Hirahara, K., Nemoto, M., Tsuji, K., Onoue, M., Kurosugi, A., Sasaki, A., and Nakayama, T.
  • Organizer: 第51回日本免疫学会学術集会
  • Int'l Joint Research
• [Presentation] Nematode ascarosides attenuate mammalian type 2 inflammatory responses (2022)
  • Author(s): Kiuchi, M., Kokubo, K., Onodera, A., Hirahara, K., and Nakayama, T.
  • Organizer: 第51回日本免疫学会学術集会
  • Int'l Joint Research
• [Presentation] Impact of circulating AIM on self-pathogen removal and its potential clinical applications (2022)
  • Author(s): Satoko Arai
  • Organizer: 2022 Japanese-French Frontiers of Science Symposium (JFFoS)
  • Int'l Joint Research
• [Presentation] Phagocytic removal of body-derived inflammatory elements and disease repair promoted by AIM (2022)
  • Author(s): Toru Miyazaki, Arai Satoko
  • Organizer: EMBO Workshop; Phagocytosis of dying cells: Molecules, mechanisms, and therapeutic implications
  • Int'l Joint Research
• [Presentation] 偽性アルドステロン症自然発症マウスの確立と腎臓におけるMac-2BPの機能解明の試み (2022)
  • Author(s): 江口彩花, 新井郷子, 宮崎徹
  • Organizer: 第45回日本分子生物学会年会
• [Presentation] A role of the phagocytic removal system in resolution of inflammation and its therapeutic implication (2022)
  • Author(s): Satoko Arai
  • Organizer: 第51回日本免疫学会学術集会
  • Int'l Joint Research
• [Presentation] 自律神経を介した 腸管制御性T細胞誘導能の解明 (2022)
  • Author(s): 松原佑太、寺谷俊昭、三上洋平、金井隆典
  • Organizer: 消化器臓器間ネットワーク研究会
• [Presentation] 細胞遺伝子発現解析を用いた、大腸における線維芽細胞の機能解析 (2022)
  • Author(s): 萩原裕也、石原利乃、高田祐明、角田潤也、岩田賢太郎、松井信平、清島亮、茂田浩平、稲垣豊、岡林剛史、佐藤俊朗、三上洋平、金井隆典
  • Organizer: 59回 消化器免疫学会
• [Presentation] Resolution of inflammation: D'ou; venons-nous? Que sommes-nous? Ou allons-nous? (2022)
  • Author(s): Yohei Mikami
  • Organizer: 第51回日本免疫学会
  • Int'l Joint Research
• [Presentation] Enrichment of type I interferon signalling in the colonic ILC2 during experimental colitis (2022)
  • Author(s): Emi Irie, Rino Ishihara, Ichiro Mizushima, Yuya Hagihara, Yoshiaki Takada, Junya Tsunoda, Yohei Mikami, Takanori Kanai
  • Organizer: 第51回日本免疫学会
  • Int'l Joint Research
• [Presentation] Dynamic kinetics of fibroblasts during acute oesophageal inflammation (2022)
  • Author(s): Kentaro Iwata, Yuya Hagihara, Yoshiaki Takada, Rino Ishihara, Yohei Mikami, Takanori Kanai
  • Organizer: 第51回日本免疫学会
  • Int'l Joint Research
• [Presentation] “Single cell analysis to better understand the pathogenesis of IBD” (2022)
  • Author(s): Yohei Mikami
  • Organizer: The 1st International Symposium of Clinical Immunology
  • Int'l Joint Research / Invited
• [Presentation] 免疫疾患横断セミナーシリーズ第3回 Human Immunology Priming Seminar ～様々な領域の分子標的療法から臨床免疫を理解しよう～ (2022)
  • Author(s): 三上洋平
  • Organizer: 日本臨床免疫学会
  • Invited
• [Presentation] 腸炎病態における腸管Th細胞の新規制御機構 (2022)
  • Author(s): 三上洋平, 寺谷俊昭, 金井隆典
  • Organizer: 第46回日本リンパ学会総会
  • Invited
• [Presentation] マクロファージ由来タンパク質AIMのセルフ・パソジェン除去機能を介した炎症収束～急性腎障害から脳梗塞まで～ (2022)
  • Author(s): 新井郷子
  • Organizer: 千葉大学リーディング研究育成プログラム「希少・難治性疾患に対する革新的治療創生研究シンポジウム」
  • Invited
• [Presentation] 炎症性腸疾患における 免疫学的病態と臓器連関 (2022)
  • Author(s): 三上 洋平
  • Organizer: 千葉大学リーディング研究育成プログラム「希少・難治性疾患に対する革新的治療創生研究」 希少・難治性疾患に対する革新的治療創生研究シンポジウム
  • Invited
• [Presentation] Single cell analysis to better understand the pathogenesis of IBD (2022)
  • Author(s): Yohei Mikami
  • Organizer: The 1st International Symposium of Clinical Immunology
  • Invited
• [Presentation] 病原性Th2細胞による難治性アレルギー性気道炎症の病態制御 (2021)
  • Author(s): 中山 俊憲、市川 智巳、小久保 幸太、木内 政宏、青木 亜美、平原 潔
  • Organizer: 第70回日本アレルギー学会学術大会
• [Presentation] ー性炎症の難治性病態形成機構について (2021)
  • Author(s): 平原 潔、中山 俊憲
  • Organizer: 第70回日本アレルギー学会学術大会
  • Invited
• [Presentation] 慢性アレルギー性結膜炎におけるIL-33-ST2-CGRP経路を介した記憶型Th2細胞の役割 (2021)
  • Author(s): 横山 美樹子、尾上 美樹、木内 政宏、平原 潔、池原 譲、海老原 伸行、中山 俊憲
  • Organizer: 第70回日本アレルギー学会学術大会
• [Presentation] ベンラリズマブによる好酸球性炎症組織局所での抗体依存性細胞傷害活性についての検討 (2021)
  • Author(s): 青木 亜美、辻 香織、小久保 幸太、木内 政宏、平原 潔、中山 俊憲
  • Organizer: 第70回日本アレルギー学会学術大会
• [Presentation] AIM/CD5LによるDAMPsの除去を介した脳梗塞の病態改善 (2021)
  • Author(s): 前原奈都美, 谷口香織, 新井郷子, 宮崎徹
  • Organizer: 第44回日本分子生物学会年会
• [Presentation] 高塩負荷は血中タンパク質AIM/CD5Lの活性化を妨げることにより急性腎障害を悪化させる (2021)
  • Author(s): Wang CT, 手塚哲史, 竹田直樹, 荒木喜美, 新井郷子, 宮崎徹
  • Organizer: 第44回日本分子生物学会年会
• [Presentation] 肝臓-腸－脳相関による新規腸管制御性T細胞の調節機構の解明 (2021)
  • Author(s): 三上 洋平, 寺谷 俊昭, 金井 隆典
  • Organizer: 臨床免疫学会
• [Presentation] MicroRNA-221/222 regulate gut homeostasis via tuning Th17 cells phenotype (2021)
  • Author(s): Yohei Mikami, Yuka Kanno, Takanori Kanai, John J O’Shea
  • Organizer: 第50回日本免疫学会
• [Presentation] Omics data analysis of the intestinal mucosal immunity involved in the pathogenesis of inflammatory bowel diseases (2021)
  • Author(s): Yohei Mikami
  • Organizer: 第50回日本免疫学会
• [Presentation] Single-cell sequencing finds cell type-specific immune dysregulation in IBD (2021)
  • Author(s): Yohei Mikami
  • Organizer: The 9th annual meeting of AOCC (AOCC 2021)
  • Invited
• [Presentation] 肝臓 -脳-腸管迷走神経反射による制御性 T細胞産生機構の解明 (2021)
  • Author(s): 三上 洋平, 寺谷 俊昭, 金井 隆典
  • Organizer: 第8回JCRベーシックリサーチカンファレンス 臨床免疫学会
  • Invited
• [Book] 臨床免疫・アレルギー科 (2023)
  • Author(s): 尾上美樹、岡野美樹子、木内政宏、海老原伸行、中山俊憲、平原潔
  • Total Pages: 7
  • Publisher: 科学評論社
• [Remarks] 千葉大学大学院医学研究院 免疫発生学HP
  • URL: https://www.m.chiba-u.jp/dept/meneki/
• [Remarks] 千葉大学大学院医学研究院 免疫発生学HP
  • URL: https://www.m.chiba-u.ac.jp/class/meneki/jisseki/index.html
• [Funded Workshop] The International Symposium on Resolution of Inflammation（2024年1月18日、幕張メッセ、千葉) (2024)