| Project Area | Integrative Research on Cancer Microenvironment Network |
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| Project/Area Number | 22112001 |
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| Research Category |
Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
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| Research Institution | The University of Tokyo |
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Principal Investigator |
MIYAZONO Kohei The University of Tokyo, 医学(系)研究科(研究院), 教授 (90209908)
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| Co-Investigator(Kenkyū-buntansha) |
AKIYAMA Tetsu 東京大学, 分子細胞生物学研究所, 教授 (70150745)
FUJITA Naoya 公益財団法人がん研究会, がん化学療法センター, 所長 (20280951)
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| Co-Investigator(Renkei-kenkyūsha) |
TAKAKURA Nobuyuki 大阪大学, 微生物病研究所, 教授 (80291954)
SATO Yasufumi 東北大学, 加齢医学研究所, 教授 (50178779)
YANO Seiji 金沢大学, がん進展制御研究所, 教授 (30294672)
KONDOH Shinae 東京工業大学, 大学院生命理工学研究科, 教授 (40314182)
MINAMI Takashi 東京大学, 先端科学技術研究センター, 特任教授 (00345141)
HEISSIG Beate 東京大学, 医科学研究所, 特任准教授 (30372931)
ABURATANI Hiroyuki 東京大学, 先端科学技術研究センター, 教授 (50211371)
MANO Hiroyuki 東京大学, 大学院医学系研究科, 教授 (90240704)
NAKA Kazuhito 金沢大学, がん進展制御研究所, 准教授 (70372688)
HARA Eiji 公益財団法人がん研究会, がん研究所, 部長 (80263268)
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| Project Fiscal Year |
2010-06-23 – 2016-03-31(Estimated)
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| Project Status |
Adopted(Fiscal Year 2015)
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| Budget Amount *help |
¥21,320,000 (Direct Cost : ¥16,400,000、Indirect Cost : ¥4,920,000)
Fiscal Year 2015 : ¥3,900,000 (Direct Cost : ¥3,000,000、Indirect Cost : ¥900,000)
Fiscal Year 2014 : ¥2,860,000 (Direct Cost : ¥2,200,000、Indirect Cost : ¥660,000)
Fiscal Year 2013 : ¥5,070,000 (Direct Cost : ¥3,900,000、Indirect Cost : ¥1,170,000)
Fiscal Year 2012 : ¥3,120,000 (Direct Cost : ¥2,400,000、Indirect Cost : ¥720,000)
Fiscal Year 2011 : ¥3,120,000 (Direct Cost : ¥2,400,000、Indirect Cost : ¥720,000)
Fiscal Year 2010 : ¥3,250,000 (Direct Cost : ¥2,500,000、Indirect Cost : ¥750,000)
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| Keywords | がん微小環境 / シグナル伝達 / 生体材料 / 生体イメージング / ゲノム科学 / 微小環境 / がん浸潤 / 転移 / 血管新生 / リンパ管新生 / ゲノム医学 |
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| Outline of Final Research Achievements |
It is now widely accepted that functional interaction between cancer cells and cancer microenvironment plays critical roles in the growth, invasion, and metastasis of cancer. For the development of new strategies for cancer treatment, it is important not only to target cancer cells themselves, but also to understand the functions of cancer microenvironment in various cancer tissues. In this research project, we have investigated: 1) dynamic changes of cancer microenvironment, 2) interaction between cancer-initiating cells and niche, 3) molecular mechanisms of angiogenesis and lymphangiogenesis, and 4) mechanisms of cancer metastasis and new methods for cancer treatment. We have conducted our research by exchanging scientific ideas and experimental techniques among the investigators in this project, including young investigators, and obtained many interesting findings.
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