Integrative Research on Cancer Microenvironment Network

• Project Area: Integrative Research on Cancer Microenvironment Network
• Project/Area Number: 22112001
• Research Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
• Allocation Type: Single-year Grants
• Research Institution: The University of Tokyo
• Principal Investigator: MIYAZONO Kohei 東京大学, 医学(系)研究科(研究院), 教授 (90209908)
• Co-Investigator(Kenkyū-buntansha): AKIYAMA Tetsu 東京大学, 分子細胞生物学研究所, 教授 (70150745) ; FUJITA Naoya 公益財団法人がん研究会, がん化学療法センター, 所長 (20280951)
• Co-Investigator(Renkei-kenkyūsha): TAKAKURA Nobuyuki 大阪大学, 微生物病研究所, 教授 (80291954) ; SATO Yasufumi 東北大学, 加齢医学研究所, 教授 (50178779) ; YANO Seiji 金沢大学, がん進展制御研究所, 教授 (30294672) ; KONDOH Shinae 東京工業大学, 大学院生命理工学研究科, 教授 (40314182) ; MINAMI Takashi 東京大学, 先端科学技術研究センター, 特任教授 (00345141) ; HEISSIG Beate 東京大学, 医科学研究所, 特任准教授 (30372931) ; TABATA Yasuhiko 京都大学, 再生医科学研究所, 教授 (50211371) ; MANO Hiroyuki 東京大学, 大学院医学系研究科, 教授 (90240704) ; NAKA Kazuhito 金沢大学, がん進展制御研究所, 准教授 (70372688) ; HARA Eiji 公益財団法人がん研究会, がん研究所, 部長 (80263268)
• Project Period (FY): 2010-04-01 – 2016-03-31
• Project Status: Completed(Fiscal Year 2015)
• Budget Amount: ¥21,320,000 (Direct Cost : ¥16,400,000、Indirect Cost : ¥4,920,000); Fiscal Year 2015 : ¥3,900,000 (Direct Cost : ¥3,000,000、Indirect Cost : ¥900,000); Fiscal Year 2014 : ¥2,860,000 (Direct Cost : ¥2,200,000、Indirect Cost : ¥660,000); Fiscal Year 2013 : ¥5,070,000 (Direct Cost : ¥3,900,000、Indirect Cost : ¥1,170,000); Fiscal Year 2012 : ¥3,120,000 (Direct Cost : ¥2,400,000、Indirect Cost : ¥720,000); Fiscal Year 2011 : ¥3,120,000 (Direct Cost : ¥2,400,000、Indirect Cost : ¥720,000); Fiscal Year 2010 : ¥3,250,000 (Direct Cost : ¥2,500,000、Indirect Cost : ¥750,000)
• Keywords: 微小環境 / シグナル伝達 / 生体材料 / 生体イメージング / ゲノム科学 / がん微小環境 / がん浸潤 / 転移 / 血管新生 / リンパ管新生 / ゲノム医学

Outline of Annual Research Achievements

1) 国際シンポジウムの開催：平成27年9月11日に東京大学小柴ホール（東京）でInternational Symposium: Integrative Research on Cancer Microenvironmentと題して国際シンポジウムを行った。海外からはDr. Naoki Oshimori (Rockfeller Univ.)とDr. Rik Derynck (Univ. of California, San Francisco)を招聘し、講演をお願いした。Oshimori博士はマウス皮膚における扁平上皮がんの薬剤耐性機構について、TGF-βがp21の発現上昇を通じてNRF2の作用を亢進させることの重要性とがん細胞の多様性について紹介した。Derynck博士はTGF-βによる上皮間葉移行（EMT）について研究し、インスリンシグナルがTGF-β受容体の細胞表面での発現を誘導することを通じてEMTを誘導すること、TGF-β受容体の誘導にはインスリン受容体の下流でAktのシグナルが重要であることを示した。これらの特別講演に加えて、近藤科江（東工大）、Beate Heissig（東大）、佐藤靖史（東北大）、高倉伸幸（大阪大）、藤田直也（がん研究所）、原英二（大阪大）、川崎善博・秋山徹（東大）が、微小環境の生体イメージング、微小環境とマトリクス・炎症の関連、血管新生とがん幹細胞ニッチ、血小板とがん転移、細胞老化とがん、非コーディングRNAの新たな機能とがん、などをテーマに講演・討論を行った。
2) 研究成果のまとめ：新学術領域研究「がん微小環境ネットワークの統合的研究」に関する成果の取りまとめを行ない、報告書を作成した。平成22～26年度までに計画研究ではNature Reviews Cancer、Nature Communications、Developmental Cell、Cell Reports、PNAS、EMBO Jなど国際一流誌に英文論文296編を発表、国際交流や共同研究、若手育成の成果をまとめて報告した。

Research Progress Status

27年度が最終年度であるため、記入しない。

Strategy for Future Research Activity

27年度が最終年度であるため、記入しない。

Research Products

• [Journal Article] Integrated nanotechnology platform for tumor-targeted multimodal imaging and therapeutic cargo release (2016)
  • Author(s): Hosoya H, Dobroff AS, Driessen WH, Cristini V, Brinker LM, Staquicini FI, Cardo-Vila M, D'Angelo S, Ferrara F, Proneth B, Lin YS, Dunphy DR, Dogra P, Melancon MP, Stafford RJ, Miyazono K, Gelovani JG, Kataoka K, Brinker CJ, Sidman RL, Arap W, Pasqualini R.
  • Journal Title: Proc Natl Acad Sci U S A Volume : 113 Pages : 1877-1882
  • DOI: 10.1073/pnas.1525796113
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Mechanisms of action of bone morphogenetic proteins in cancer (2016)
  • Author(s): Davis H, Raja E, Miyazono K, Tsubakihara Y, Moustakas A.
  • Journal Title: Cytokine Growth Factor Rev. Volume : 27 Pages : 81-92
  • DOI: 10.1016/j.cytogfr.2015.11.009
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] The Arkadia-ESRP2 axis suppresses tumor progression: analyses in clear-cell renal cell carcinoma (2016)
  • Author(s): Mizutani A, Koinuma D, Seimiya H, Miyazono K.
  • Journal Title: Oncogene Volume : - Pages : -
  • DOI: 10.1038/onc.2015.412
  • Peer Reviewed / Open Access
• [Journal Article] RNA-binding motif protein 47 inhibits Nrf2 activity to suppress tumor growth in lung adenocarcinoma (2016)
  • Author(s): Sakurai T, Isogaya K, Sakai S, Morikawa M, Morishita Y, Ehata S, Miyazono K, Koinuma D.
  • Journal Title: Oncogene Volume : - Pages : -
  • DOI: 10.1038/onc.2016.35
  • Peer Reviewed / Open Access
• [Journal Article] Smad4 Decreases the Population of Pancreatic Cancer-Initiating Cells through Transcriptional Repression of ALDH1A1 (2015)
  • Author(s): Hoshino Y, Nishida J, Katsuno Y, Koinuma D, Aoki T, Kokudo N, Miyazono K, Ehata S.
  • Journal Title: American Journal of Pathology Volume : 印刷中 Pages : 印刷中
  • DOI: 10.1016/j.ajpath.2015.01.011
  • Peer Reviewed
• [Journal Article] MicroRNA regulons in tumor microenvironment (2015)
  • Author(s): Suzuki HI, Katsura A, Matsuyama H, Miyazono K.
  • Journal Title: Oncogene Volume : 印刷中 Pages : 印刷中
  • DOI: 10.1038/onc.2014.254
  • Peer Reviewed
• [Journal Article] A Smad3 and TTF-1/NKX2-1 complex regulates Smad4-independent gene expression (2014)
  • Author(s): Isogaya K, Koinuma D, Tsutsumi S, Saito RA, Miyazawa K, Aburatani H, Miyazono K.
  • Journal Title: Cell Research Volume : 24 Pages : 994-1008
  • DOI: 10.1038/cr.2014.97
  • Peer Reviewed
• [Journal Article] Expression of platelet-derived growth factor receptor β is maintained by Prox1 in lymphatic endothelial cells and is required for tumor lymphangiogenesis (2014)
  • Author(s): Miyazaki H, Yoshimatsu Y, Akatsu Y, Mishima K, Fukayama M, Watabe T, Miyazono K.
  • Journal Title: Cancer Science Volume : 105 Pages : 1116-1123
  • DOI: 10.1111/cas.12476
  • Peer Reviewed / Open Access
• [Journal Article] Roles of TGF-β family signals in the fate determination of pluripotent stem cells. (2014)
  • Author(s): Itoh F, Watabe T, Miyazono K.
  • Journal Title: Seminars in Cell and Developmental Biology Volume : 32 Pages : 98-106
  • DOI: 10.1016/j.semcdb.2014.05.017
  • Peer Reviewed
• [Journal Article] Transforming growth factor-β-induced lncRNA-Smad7 inhibits apoptosis of mouse breast cancer JygMC(A) cells. (2014)
  • Author(s): Arase M, Horiguchi K, Ehata S, Morikawa M, Tsutsumi S, Aburatani H, Miyazono K, Koinuma D.
  • Journal Title: Cancer Science Volume : 105 Pages : 974-982
  • DOI: 10.1111/cas.12454
  • Peer Reviewed / Open Access
• [Journal Article] 5-Hydroxymethylcytosine plays a critical role in glioblastomagenesis by recruiting the CHTOP-methylosome complex. (2014)
  • Author(s): Takai H, Masuda K, Sato T, Sakaguchi Y, Suzuki T, Suzuki T, Koyama-Nasu R, Nasu-Nishimura Y, Katou Y, Ogawa H, Morishita Y, Kozuka-Hata H, Oyama M, Todo T, Ino Y, Mukasa A, Saito N, Toyoshima C, Shirahige K, Akiyama T.
  • Journal Title: Cell Reports Volume : 9 Pages : 48-60
  • DOI: 10.1016/j.celrep.2014.08.071
  • Peer Reviewed / Open Access
• [Journal Article] Expression of Aggrus/podoplanin in bladder cancer and its role in pulmonary metastasis (2014)
  • Author(s): Takagi S, Oh-hara T, Sato S, Gong B, Takami M, Fujita N.
  • Journal Title: International Journal of Cancer Volume : 134 Pages : 2605-2614
  • DOI: 10.1002/ijc.28602
  • Peer Reviewed / Open Access
• [Journal Article] The miR-363-GATA6-Lgr5 pathway is critical for colorectal tumorigenesis (2014)
  • Author(s): Tsuji S
  • Journal Title: Nat. Commun. Volume : 5 Pages : 3150
  • DOI: 10.1038/ncomms4150
  • Peer Reviewed
• [Journal Article] Bone morphogenetic protein-9 inhibits lymphatic vessel formation via activin receptor-like kinase 1 during development and cancer progression (2013)
  • Author(s): Yoshimatsu Y
  • Journal Title: Proc. Natl. Acad. Sci. U. S. A. Volume : 10 Pages : 18940-18945
  • DOI: 10.1073/pnas.1310479110
  • Peer Reviewed
• [Journal Article] Computational dissection of distinct microRNA activity signatures associated with peripheral T cell lymphoma subtypes (2013)
  • Author(s): Suzuki HI
  • Journal Title: Leukemia Volume : 27 Pages : 2107-2111
  • DOI: 10.1038/leu.2013.121
  • Peer Reviewed
• [Journal Article] TGF-β drives epithelial-mesenchymal transition through δEF1-mediated downregulation of ESRP (2012)
  • Author(s): Horiguchi K, Miyazono K, et al
  • Journal Title: Oncogene Volume : (掲載確定)(印刷中)
  • DOI: 10.1038/onc.2011.493
  • Peer Reviewed
• [Journal Article] A member of the ETS family, EHF, and the ATPase RUVBL1 inhibit p53-mediated apoptosis (2011)
  • Author(s): Taniue K, Akiyama T, et al
  • Journal Title: EMBO Report Volume : 12 Pages : 682-689
  • DOI: 10.1038/embor.2011.81
  • Peer Reviewed
• [Journal Article] Prevention of hematogenous metastasis by neutralizing mice and its chimericanti-Aggrus/podoplanin antibodies (2011)
  • Author(s): Nakazawa Y, Fujita N, et al
  • Journal Title: Cancer Science Volume : 102 Pages : 2051-2057
  • DOI: 10.1111/j.1349-7006.2011.02058.x
  • Peer Reviewed
• [Journal Article] Identification and characterization of a resident vascular stem/progenitor cell population in preexisting blood vessels (2011)
  • Author(s): Naito H, Takakura N, et al
  • Journal Title: EMBO Journal Volume : 31 Pages : 842-855
  • DOI: 10.1038/emboj.2011.465
  • Peer Reviewed
• [Journal Article] The EGFR ligands amphiregulin and heparin-binding EGF-like growth factor promote peritoneal carcinomatosis in CXCR4-expressing gastric cancer (2011)
  • Author(s): Yasumoto K, Yano S, et al
  • Journal Title: Clinical Cancer Research Volume : 17 Pages : 3619-3630
  • DOI: 10.1158/1078-0432.CCR-10-2475
  • Peer Reviewed
• [Journal Article] Detection of the onset of ischemia and carcinogenesis by hypoxia-inducible transcription factor-based in vivo bioluminescence imaging (2011)
  • Author(s): Kadonosono T, Kizaka-Kondoh S, et al
  • Journal Title: PLoS One Volume : 6 Pages : E26640
  • DOI: 10.1371/journal.pone.0026640
  • Peer Reviewed
• [Journal Article] Plasminogen deficiency attenuates postnatal erythropoiesis in male C57BL/6 mice through decreased activity of the LH-testosterone axis (2011)
  • Author(s): Okaji Y, Heissig B, et al
  • Journal Title: Experimental Hematology Volume : 40 Pages : 143-154
  • DOI: 10.1016/j.exphem.2011.10.008
  • Peer Reviewed
• [Journal Article] DNA damage signaling triggers degradation of histone methyltransferases through APC/C(Cdh1) in senescent cells (2011)
  • Author(s): Takahashi A, Hara E, et al
  • Journal Title: Molecular Cell Volume : 45 Pages : 123-131
  • DOI: 10.1016/j.molcel.2011.10.018
  • Peer Reviewed
• [Journal Article] Enhancement of ectopic osteoid formation following the dual release of bone morphogenetic protein-2 and Wnt1 inducible signaling pathway protein 1 from gelatin sponges (2011)
  • Author(s): Kohara, H., Tabata, Y.
  • Journal Title: Biomaterials Volume : 32 Pages : 5726-5732
  • DOI: 10.1016/j.biomaterials.2011.04.035
  • Peer Reviewed
• [Journal Article] Activation of Bmp2-Smad1 signal and its regulation by coordinated alteration of H3K27 trimethylation in Ras-induced senescence (2011)
  • Author(s): Kaneda A, Miyazono K, Aburatani H, et al
  • Journal Title: PLoS Genetics Volume : 7 Pages : E1002359
  • DOI: 10.1371/journal.pgen.1002359
  • Peer Reviewed
• [Journal Article] Epigenetically coordinated GATA2 binding is necessary for endothelium-specific endomucin expression (2011)
  • Author(s): Kanki Y, Minami T, et al
  • Journal Title: EMBO Journal Volume : 30 Pages : 2582-2595
  • DOI: 10.1038/emboj.2011.173
  • Peer Reviewed
• [Journal Article] TGF-β regulates isoform switching of FGF receptors and epithelial-mesenchymal transition. (2011)
  • Author(s): Shirakihara T, Miyazono K, et al.
  • Journal Title: EMBO Journal Volume : 30 Pages : 783-795
  • Peer Reviewed
• [Journal Article] Genome-wide approaches reveal functional IL-4 inducible STAT6 binding to the vascular cell adhesion molecule-1 promoter. (2011)
  • Author(s): Tozawa H, Minami T, et al.
  • Journal Title: Molecular and Cellular Biology Volume : (掲載確定(印刷中))
  • Peer Reviewed
• [Journal Article] The novel metastasis promoter Merm1/Wbscr22 enhances tumor cell survival in the vasculature by suppressing Zac1/p53-dependent apoptosis. (2011)
  • Author(s): Nakazawa Y, Fujita N, et al.
  • Journal Title: Cancer Research Volume : 71 Pages : 1146-1155
  • Peer Reviewed
• [Journal Article] Transient PI3K inhibition induces apoptosis and overcomes HGF-mediated resistance to EGFR-TKIs in EGFR mutant lung cancer. (2011)
  • Author(s): Donev IS, Yano S, et al.
  • Journal Title: Clinical Cancer Research Volume : (掲載確定(印刷中))
  • Peer Reviewed
• [Journal Article] Sunspot, a link between Wingless signaling and endoreplication in Drosophila. (2010)
  • Author(s): Taniue K, Akiyama T, et al.
  • Journal Title: Development Volume : 137 Pages : 1755-1764
  • Peer Reviewed
• [Journal Article] Apelin induces enlarged and nonleaky blood vessels for functional recovery from ischemia. (2010)
  • Author(s): Kidoya H, Takakura N, et al.
  • Journal Title: Blood Volume : 115 Pages : 3166-3174
  • Peer Reviewed
• [Journal Article] Isolation of a small vasohibin-binding protein (SVBP) and its role in vasohibin secretion. (2010)
  • Author(s): Suzuki Y, Sato Y, et al.
  • Journal Title: Journal of Cell Science Volume : 123 Pages : 3094-4101
  • Peer Reviewed
• [Journal Article] Adipocyte-derived microvesicles are associated with multiple angiogenic factors and induce angiogenesis in vivo and in vitro. (2010)
  • Author(s): Aoki N, Heissig, B, et al.
  • Journal Title: Endocrinology Volume : 151 Pages : 2567-2576
  • Peer Reviewed
• [Journal Article] In vivo imaging of HIF-active rumors by an oxygen-dependent degradation protein probe with an interchangeable labeling system. (2010)
  • Author(s): Kuchimaru T, Kizaka-Kondoh S, et al.
  • Journal Title: PLoS One Volume : 5 Pages : e15736
  • Peer Reviewed
• [Presentation] Regulation of the progression of lung cancer by TGF-beta (2015)
  • Author(s): Miyazono K.
  • Organizer: FASEB Scientific Research Conference: The TGF-Beta Superfamily: Signaling in Development and Disease
  • Place of Presentation: Base Village Conference Center (Snowmass, CO, USA)
  • Year and Date: 2015-07-12 – 2015-07-17
  • Int'l Joint Research / Invited
• [Presentation] The Arkadia-ESRP2 axis suppresses tumor progression: Analyses in clear cell renal cell carcinoma (2015)
  • Author(s): Mizutani A, Koinuma D, Seimiya H, Miyazono K
  • Organizer: AACR Annual Meeting 2015
  • Place of Presentation: Pennsylvania Convention Center (Philadelphia, PA, USA)
  • Year and Date: 2015-04-18 – 2015-04-22
  • Int'l Joint Research
• [Presentation] リンパ管形成におけるTGF-βファミリーシグナルの役割 (2015)
  • Author(s): 吉松康裕、Yulia G Lee、赤津裕一、田口瑠奈、鈴木洋、Sara I Cunha、鈴木夕佳、山崎智子、桂彰宏、森下保幸、S Paul Oh、Teresa A Zimmers、Se-Jin Lee、Kristian Pietras、Gou Young Koh、渡部徹郎、宮園浩平
  • Organizer: がん研究分野の特性等を踏まえた支援活動・公開シンポジウム
  • Place of Presentation: 学術総合センター（東京都千代田区）
  • Year and Date: 2015-01-27 – 2015-01-28
• [Presentation] TGF-β signaling inhibitor eradicates chronic myelogenous leukemia stem cells (2015)
  • Author(s): 仲 一仁、石原薫理、定免由枝
  • Organizer: がん研究分野の特性等を踏まえた支援活動・公開シンポジウム
  • Place of Presentation: 学術総合センター（東京都千代田区）
  • Year and Date: 2015-01-27 – 2015-01-28
• [Presentation] Roles of the protein tyrosine phosphatase VE-PTP in endothelial cells of tumor vessels and normal their counterparts (2015)
  • Author(s): 村田陽二、Kemala Isnainiasih Mantilidewi、森宗昌、小谷武徳、草苅伸也、大西浩史、的崎尚
  • Organizer: がん研究分野の特性等を踏まえた支援活動・公開シンポジウム
  • Place of Presentation: 学術総合センター（東京都千代田区）
  • Year and Date: 2015-01-27 – 2015-01-28
• [Presentation] CMLに対するIFNαの作用における転写因子C/EBPβの関与 (2015)
  • Author(s): 横田明日美、平位秀世、林嘉宏、田村彰広、佐藤淳至、岩佐磨佐紀、藤城綾、庄司月美、三浦康生、前川平
  • Organizer: がん研究分野の特性等を踏まえた支援活動・公開シンポジウム
  • Place of Presentation: 学術総合センター（東京都千代田区）
  • Year and Date: 2015-01-27 – 2015-01-28
• [Presentation] TGF-βファミリーのがん微小環境に及ぼす作用とがん治療戦略 (2015)
  • Author(s): 宮園 浩平
  • Organizer: がん研究分野の特性等を踏まえた支援活動・公開シンポジウム
  • Place of Presentation: 学術総合センター（東京都千代田区）
  • Year and Date: 2015-01-27 – 2015-01-28
  • Invited
• [Presentation] Effect of Hsp90 inhibitor 17-DMAG on ligand-triggered resistance to alectinib in EML4-ALK NSCLC cells (2014)
  • Author(s): Azusa Tanimoto
  • Organizer: Third AACR-IASLC Joint Conference on the Molecular Origins of Lung Cancer
  • Place of Presentation: Hard Rock Hotel (San Diego, USA)
  • Year and Date: 20140106-20140109
• [Presentation] Resistance to EGFR TKIs (2013)
  • Author(s): Seiji Yano
  • Organizer: IASLC 15th World Conference on Lung Cancer
  • Place of Presentation: Convention & Exhibition Centre (Sydney, Australia)
  • Year and Date: 20131027-20131030
  • Invited
• [Presentation] TGF-beta signals in tumor microenvironment and treatment of cancer (2013)
  • Author(s): Kohei Miyazono
  • Organizer: 第72回日本癌学会学術総会
  • Place of Presentation: パシフィコ横浜（神奈川）
  • Year and Date: 20131003-20131005
  • Invited
• [Presentation] Elucidation of the hypoxia-inducible factor involvement in tumorigenesis and metastasis by using mouse models (2013)
  • Author(s): Shinae Kondoh
  • Organizer: 第72回日本癌学会学術総会
  • Place of Presentation: パシフィコ横浜（神奈川）
  • Year and Date: 20131003-20131005
  • Invited
• [Presentation] Development of anti-Aggrus/podoplanin antibodies suppressing hematogenous metastasis and tumor growth in vivo (2013)
  • Author(s): Naoya Fujita
  • Organizer: 第72回日本癌学会学術総会
  • Place of Presentation: パシフィコ横浜（神奈川）
  • Year and Date: 20131003-20131005
  • Invited
• [Presentation] Vascular niche and stem cell regulation (2013)
  • Author(s): Nobuyuki Takakura
  • Organizer: 第72回日本癌学会学術総会
  • Place of Presentation: パシフィコ横浜（神奈川）
  • Year and Date: 20131003-20131005
  • Invited
• [Presentation] Role of 5-hydroxymethylcytosine in the tumorigenicity of glioblastoma cells (2013)
  • Author(s): Hiroki Takai, Tetsu Akiyama
  • Organizer: 第72回日本癌学会学術総会
  • Place of Presentation: パシフィコ横浜（神奈川）
  • Year and Date: 20131003-20131005
  • Invited
• [Presentation] Obesity-induced gut microbial metabolite promotes liver cancer through senescence secretome (2013)
  • Author(s): Eiji Hara
  • Organizer: 17th International Symposium on Cells of the Hepatic Sinusoid
  • Place of Presentation: 大阪国際会議場（大阪）
  • Year and Date: 20130924-20130925
  • Invited
• [Presentation] Keynote Presentation: EMT and EndMT induced by TGF-beta (2013)
  • Author(s): Kohei Miyazono
  • Organizer: UCSF Symposium: Transforming Growth Factor Signaling
  • Place of Presentation: UCSF (San Francisco, U.S.A.)
  • Year and Date: 20130405-20130406
  • Invited
• [Presentation] 腫瘍血管新生制御の分子基盤 (2012)
  • Author(s): 佐藤靖史
  • Organizer: 千里ライフサイエンスセミナー「がんの転移・浸潤と微小環境」
  • Place of Presentation: 千里ライフサイエンスセンタービル(大阪府豊中市)(招待講演)
  • Year and Date: 2012-02-24
• [Presentation] がん幹細胞とそれを支持する血管ニッチ (2012)
  • Author(s): 高倉伸幸
  • Organizer: 千里ライフサイエンスセミナー「がんの転移・浸潤と微小環境」
  • Place of Presentation: 千里ライフサイエンスセンタービル(大阪府豊中市)(招待講演)
  • Year and Date: 2012-02-24
• [Presentation] 腫瘍の低酸素環境応答とその可視化 (2012)
  • Author(s): 近藤科江
  • Organizer: 千里ライフサイエンスセミナー「がんの転移・浸潤と微小環境」
  • Place of Presentation: 千里ライフサイエンスセンタービル(大阪府豊中市)(招待講演)
  • Year and Date: 2012-02-24
• [Presentation] 腫瘍微小循環の機能的破綻 (2012)
  • Author(s): 宮園浩平
  • Organizer: 千里ライフサイエンスセミナー「がんの転移・浸潤と微小環境」
  • Place of Presentation: 千里ライフサイエンスセンタービル(大阪府豊中市)(招待講演)
  • Year and Date: 2012-02-24
• [Presentation] がん細胞の環境応答-臨床的立場から (2012)
  • Author(s): 矢野聖二
  • Organizer: 千里ライブサイエンスセミナー「がんの転移・浸潤と微小環境」
  • Place of Presentation: 千里ライフサイエンスセンタービル(大阪府豊中市)(招待講演)
  • Year and Date: 2012-02-24
• [Presentation] TGF-beta, EMT, and TGF-beta signaling inhibitors in cancer progression (2011)
  • Author(s): Kohei Miyazono
  • Organizer: Keystone symposia : Epithelial plasticity and epithelial to mesenchymal transition
  • Place of Presentation: Fairmont Waterfront(カナダ、バンクーバー)
  • Year and Date: 2011-01-25
• [Presentation] がん細胞とこれを取り巻く細胞・新しいがん治療の試み(市民公開講座) (2010)
  • Author(s): 宮園浩平
  • Organizer: 第33回日本分子生物学会年会・第83回日本生化学会大会・合同年会
  • Place of Presentation: 東京大学安田講堂(東京都文京区)
  • Year and Date: 2010-12-11
• [Presentation] Roles of TGF-beta signaling in cancer(大会長企画シンポジウム) (2010)
  • Author(s): Kohei Miyazono
  • Organizer: 第33回日本分子生物学会年会・第83回日本生化学会大会・合同年会
  • Place of Presentation: 神戸ポートアイランド(兵庫県神戸市)
  • Year and Date: 2010-12-09
• [Presentation] Tissue specific gene expression, insights from the genome-wide and epigenetical analysis in vitro and in vivo(シンポジウム) (2010)
  • Author(s): 南敬
  • Organizer: 第18回日本血管生物医学会学術集会
  • Place of Presentation: 梅田スカイビル(大阪府大阪市)
  • Year and Date: 2010-12-01
• [Presentation] がんハイポキシアの生体イメージング(モーニングレクチャー) (2010)
  • Author(s): 近藤科江
  • Organizer: 第69回日本癌学会学術総会
  • Place of Presentation: 大阪国際コンベンションセンター(大阪府大阪市)
  • Year and Date: 2010-09-24
• [Presentation] がん幹細胞と血管ニッチ(モーニングレクチャー) (2010)
  • Author(s): 高倉伸幸
  • Organizer: 第69回日本癌学会学術総会
  • Place of Presentation: 大阪国際コンベンションセンター(大阪府大阪市)
  • Year and Date: 2010-09-24
• [Presentation] 癌増殖における線維素溶解系因子の役割と新規治療法の開発 (2010)
  • Author(s): 石原誠人、Beate Heissig, ほか
  • Organizer: 第69回日本癌学会学術総会
  • Place of Presentation: 大阪国際コンベンションセンター(大阪府大阪市)
  • Year and Date: 2010-09-24
• [Presentation] EGFR変異肺がんのチロシンキナーゼ阻害薬耐性と治療戦略(シンポジウム) (2010)
  • Author(s): 矢野聖二
  • Organizer: 第69回日本癌学会学術総会
  • Place of Presentation: 大阪国際コンベンションセンター(大阪府大阪市)
  • Year and Date: 2010-09-23
• [Presentation] 血管新生抑制とがん(モーニングレクチャー) (2010)
  • Author(s): 佐藤靖史
  • Organizer: 第69回日本癌学会学術総会
  • Place of Presentation: 大阪国際コンベンションセンター(大阪府大阪市)
  • Year and Date: 2010-09-23
• [Presentation] TGF-βシグナルのがん幹細胞と微小環境における役割(日本癌学会-アメリカ癌学会合同シンポジウム) (2010)
  • Author(s): 宮園浩平
  • Organizer: 第69回日本癌学会学術総会
  • Place of Presentation: 大阪国際コンベンションセンター(大阪府大阪市)
  • Year and Date: 2010-09-22
• [Presentation] 抗がん剤耐性機構の解明とその克服(がん研究入門コース) (2010)
  • Author(s): 藤田直也
  • Organizer: 第69回日本癌学会学術総会
  • Place of Presentation: 大阪国際コンベンションセンター(大阪府大阪市)
  • Year and Date: 2010-09-22
• [Presentation] 膠芽腫幹細胞におけるcyclin D2の重要な役割(English workshop) (2010)
  • Author(s): 那須亮、秋山徹, ほか
  • Organizer: 第69回日本癌学会学術総会
  • Place of Presentation: 大阪国際コンベンションセンター(大阪府大阪市)
  • Year and Date: 2010-09-22
• [Remarks] がん微小環境ネットワークの統合的研究
  • URL: http://cancer-microenvironment.jp/index.html
• [Remarks] 文部科学省科学研究費補助金「新学術領域研究（研究領域提案型）」がん微小環境ネットワークの統合的研究
  • URL: http://cancer-microenvironment.jp/index.html
• [Remarks] 東京大学大学院医学系研究科病因・病理学専攻分子病理学分野
  • URL: http://beta-lab.umin.ac.jp/
• [Remarks] 文部科学省科学研究費補助金「新学術領域研究（研究領域提案型）」がん微小環境ネットワークの統合的研究
  • URL: http://cancer-microenvironment.jp/index.html
• [Remarks]
  • URL: http://cancer-microenvironment.jp/index.html
• [Remarks]
  • URL: http://cancer-microenvironment.jp/
• [Funded Workshop] International Symposium: Integrative Research on Cancer Microenvironment Network (2015)
  • Place of Presentation: 東京大学小柴ホール（東京都・文京区）
  • Year and Date: 2015-09-11 – 2015-09-11