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Integrative Research on Cancer Microenvironment Network

Administrative Group

Project AreaIntegrative Research on Cancer Microenvironment Network
Project/Area Number 22112001
Research Category

Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

Allocation TypeSingle-year Grants
Review Section Biological Sciences
Research InstitutionThe University of Tokyo

Principal Investigator

MIYAZONO Kohei  東京大学, 医学(系)研究科(研究院), 教授 (90209908)

Co-Investigator(Kenkyū-buntansha) AKIYAMA Tetsu  東京大学, 分子細胞生物学研究所, 教授 (70150745)
FUJITA Naoya  公益財団法人がん研究会, がん化学療法センター, 所長 (20280951)
Co-Investigator(Renkei-kenkyūsha) TAKAKURA Nobuyuki  大阪大学, 微生物病研究所, 教授 (80291954)
SATO Yasufumi  東北大学, 加齢医学研究所, 教授 (50178779)
YANO Seiji  金沢大学, がん進展制御研究所, 教授 (30294672)
KONDOH Shinae  東京工業大学, 大学院生命理工学研究科, 教授 (40314182)
MINAMI Takashi  東京大学, 先端科学技術研究センター, 特任教授 (00345141)
HEISSIG Beate  東京大学, 医科学研究所, 特任准教授 (30372931)
TABATA Yasuhiko  京都大学, 再生医科学研究所, 教授 (50211371)
ABURATANI Hiroyuki  東京大学, 先端科学技術研究センター, 教授 (10202657)
MANO Hiroyuki  東京大学, 大学院医学系研究科, 教授 (90240704)
NAKA Kazuhito  金沢大学, がん進展制御研究所, 准教授 (70372688)
HARA Eiji  公益財団法人がん研究会, がん研究所, 部長 (80263268)
Project Period (FY) 2010-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥21,320,000 (Direct Cost: ¥16,400,000、Indirect Cost: ¥4,920,000)
Fiscal Year 2015: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2014: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2013: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2012: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2011: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2010: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Keywords微小環境 / シグナル伝達 / 生体材料 / 生体イメージング / ゲノム科学 / がん微小環境 / がん浸潤 / 転移 / 血管新生 / リンパ管新生 / ゲノム医学
Outline of Annual Research Achievements

1) 国際シンポジウムの開催:平成27年9月11日に東京大学小柴ホール(東京)でInternational Symposium: Integrative Research on Cancer Microenvironmentと題して国際シンポジウムを行った。海外からはDr. Naoki Oshimori (Rockfeller Univ.)とDr. Rik Derynck (Univ. of California, San Francisco)を招聘し、講演をお願いした。Oshimori博士はマウス皮膚における扁平上皮がんの薬剤耐性機構について、TGF-βがp21の発現上昇を通じてNRF2の作用を亢進させることの重要性とがん細胞の多様性について紹介した。Derynck博士はTGF-βによる上皮間葉移行(EMT)について研究し、インスリンシグナルがTGF-β受容体の細胞表面での発現を誘導することを通じてEMTを誘導すること、TGF-β受容体の誘導にはインスリン受容体の下流でAktのシグナルが重要であることを示した。これらの特別講演に加えて、近藤科江(東工大)、Beate Heissig(東大)、佐藤靖史(東北大)、高倉伸幸(大阪大)、藤田直也(がん研究所)、原英二(大阪大)、川崎善博・秋山徹(東大)が、微小環境の生体イメージング、微小環境とマトリクス・炎症の関連、血管新生とがん幹細胞ニッチ、血小板とがん転移、細胞老化とがん、非コーディングRNAの新たな機能とがん、などをテーマに講演・討論を行った。
2) 研究成果のまとめ:新学術領域研究「がん微小環境ネットワークの統合的研究」に関する成果の取りまとめを行ない、報告書を作成した。平成22~26年度までに計画研究ではNature Reviews Cancer、Nature Communications、Developmental Cell、Cell Reports、PNAS、EMBO Jなど国際一流誌に英文論文296編を発表、国際交流や共同研究、若手育成の成果をまとめて報告した。

Research Progress Status

27年度が最終年度であるため、記入しない。

Strategy for Future Research Activity

27年度が最終年度であるため、記入しない。

Report

(7 results)
  • 2015 Annual Research Report
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Annual Research Report
  • 2012 Annual Research Report
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (95 results)

All 2016 2015 2014 2013 2012 2011 2010 Other

All Journal Article (46 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 46 results,  Open Access: 13 results,  Acknowledgement Compliant: 2 results) Presentation (41 results) (of which Int'l Joint Research: 2 results,  Invited: 18 results) Remarks (7 results) Funded Workshop (1 results)

  • [Journal Article] Integrated nanotechnology platform for tumor-targeted multimodal imaging and therapeutic cargo release2016

    • Author(s)
      Hosoya H, Dobroff AS, Driessen WH, Cristini V, Brinker LM, Staquicini FI, Cardo-Vila M, D'Angelo S, Ferrara F, Proneth B, Lin YS, Dunphy DR, Dogra P, Melancon MP, Stafford RJ, Miyazono K, Gelovani JG, Kataoka K, Brinker CJ, Sidman RL, Arap W, Pasqualini R.
    • Journal Title

      Proc Natl Acad Sci U S A.

      Volume: 113 Issue: 7 Pages: 1877-1882

    • DOI

      10.1073/pnas.1525796113

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Mechanisms of action of bone morphogenetic proteins in cancer2016

    • Author(s)
      Davis H, Raja E, Miyazono K, Tsubakihara Y, Moustakas A.
    • Journal Title

      Cytokine Growth Factor Rev.

      Volume: 27 Pages: 81-92

    • DOI

      10.1016/j.cytogfr.2015.11.009

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] The Arkadia-ESRP2 axis suppresses tumor progression: analyses in clear-cell renal cell carcinoma2016

    • Author(s)
      Mizutani A, Koinuma D, Seimiya H, Miyazono K.
    • Journal Title

      Oncogene

      Volume: - Issue: 27 Pages: 3514-3523

    • DOI

      10.1038/onc.2015.412

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] RNA-binding motif protein 47 inhibits Nrf2 activity to suppress tumor growth in lung adenocarcinoma2016

    • Author(s)
      Sakurai T, Isogaya K, Sakai S, Morikawa M, Morishita Y, Ehata S, Miyazono K, Koinuma D
    • Journal Title

      Oncogene

      Volume: 35 Issue: 38 Pages: 5000

    • DOI

      10.1038/onc.2016.35

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Smad4 Decreases the Population of Pancreatic Cancer-Initiating Cells through Transcriptional Repression of ALDH1A12015

    • Author(s)
      Hoshino Y, Nishida J, Katsuno Y, Koinuma D, Aoki T, Kokudo N, Miyazono K, Ehata S.
    • Journal Title

      American Journal of Pathology

      Volume: 印刷中 Issue: 5 Pages: 1457-1470

    • DOI

      10.1016/j.ajpath.2015.01.011

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] MicroRNA regulons in tumor microenvironment2015

    • Author(s)
      Suzuki HI, Katsura A, Matsuyama H, Miyazono K.
    • Journal Title

      Oncogene

      Volume: 印刷中 Issue: 24 Pages: 3085-3094

    • DOI

      10.1038/onc.2014.254

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A Smad3 and TTF-1/NKX2-1 complex regulates Smad4-independent gene expression2014

    • Author(s)
      Isogaya K, Koinuma D, Tsutsumi S, Saito RA, Miyazawa K, Aburatani H, Miyazono K.
    • Journal Title

      Cell Research

      Volume: 24 Issue: 8 Pages: 994-1008

    • DOI

      10.1038/cr.2014.97

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Expression of platelet-derived growth factor receptor β is maintained by Prox1 in lymphatic endothelial cells and is required for tumor lymphangiogenesis2014

    • Author(s)
      Miyazaki H, Yoshimatsu Y, Akatsu Y, Mishima K, Fukayama M, Watabe T, Miyazono K.
    • Journal Title

      Cancer Science

      Volume: 105 Issue: 9 Pages: 1116-1123

    • DOI

      10.1111/cas.12476

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Roles of TGF-β family signals in the fate determination of pluripotent stem cells.2014

    • Author(s)
      Itoh F, Watabe T, Miyazono K.
    • Journal Title

      Seminars in Cell and Developmental Biology

      Volume: 32 Pages: 98-106

    • DOI

      10.1016/j.semcdb.2014.05.017

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Transforming growth factor-β-induced lncRNA-Smad7 inhibits apoptosis of mouse breast cancer JygMC(A) cells2014

    • Author(s)
      Arase M, Horiguchi K, Ehata S, Morikawa M, Tsutsumi S, Aburatani H, Miyazono K, Koinuma D.
    • Journal Title

      Cancer Science

      Volume: 105 Issue: 8 Pages: 974

    • DOI

      10.1111/cas.12454

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] 5-Hydroxymethylcytosine plays a critical role in glioblastomagenesis by recruiting the CHTOP-Methylosome complex2014

    • Author(s)
      Hiroki Takai, Tetsu Akiyama et al.
    • Journal Title

      Cell Reports

      Volume: 9 Issue: 1 Pages: 48

    • DOI

      10.1016/j.celrep.2014.08.071

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Expression of Aggrus/podoplanin in bladder cancer and its role in pulmonary metastasis2014

    • Author(s)
      Takagi S, Oh-hara T, Sato S, Gong B, Takami M, Fujita N.
    • Journal Title

      International Journal of Cancer

      Volume: 134 Issue: 11 Pages: 2605-2614

    • DOI

      10.1002/ijc.28602

    • Related Report
      2014 Annual Research Report 2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The miR-363-GATA6-Lgr5 pathway is critical for colorectal tumorigenesis2014

    • Author(s)
      Tsuji S
    • Journal Title

      Nat. Commun.

      Volume: 5 Issue: 1 Pages: 3150-3150

    • DOI

      10.1038/ncomms4150

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Bone morphogenetic protein-9 inhibits lymphatic vessel formation via activin receptor-like kinase 1 during development and cancer progression2013

    • Author(s)
      Yoshimatsu Y
    • Journal Title

      Proc. Natl. Acad. Sci. U. S. A.

      Volume: 10 Issue: 47 Pages: 18940-18945

    • DOI

      10.1073/pnas.1310479110

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Computational dissection of distinct microRNA activity signatures associated with peripheral T cell lymphoma subtypes2013

    • Author(s)
      Suzuki HI
    • Journal Title

      Leukemia

      Volume: 27 Issue: 10 Pages: 2107-2111

    • DOI

      10.1038/leu.2013.121

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Widespread inference of weighted microRNA-mediated gene regulation in cancer transcriptome analysis2013

    • Author(s)
      Suzuki HI
    • Journal Title

      Nucleic Acids Res

      Volume: 41 Issue: 5 Pages: e62-e62

    • DOI

      10.1093/nar/gks1439

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Genome-wide mechanisms of Smad binding2013

    • Author(s)
      Morikawa M
    • Journal Title

      Oncogene

      Volume: 32 Issue: 13 Pages: 1609

    • DOI

      10.1038/onc.2012.191

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ASBEL, an ANA/BTG3 antisense transcript required for tumorigenicity of ovarian carcinoma2013

    • Author(s)
      Yanagida S, Taniue K, Yamamoto T. (9名)
    • Journal Title

      Sci Rep

      Volume: Vol.3 Issue: 1 Pages: 1305-1305

    • DOI

      10.1038/srep01305

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cytotoxic activity of Tivantinib (ARQ 197) is not due solely to c-MET inhibition2013

    • Author(s)
      Katayama R
    • Journal Title

      Cancer Res

      Volume: 印刷中

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] EGFR-TKI resistance due to BIM polymorphism can be circumvented in combination with HDAC inhibition.2013

    • Author(s)
      Nakagawa T, Yano S, et al.
    • Journal Title

      Cancer Res

      Volume: 73 Issue: 8 Pages: 2428-34

    • DOI

      10.1158/0008-5472.can-12-3479

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] microRNA-125b inhibits tube formation of blood vessels through translational suppression of VE-cadherin2012

    • Author(s)
      Muramatsu F.
    • Journal Title

      Oncogene

      Volume: (In press) Issue: 4 Pages: 414-421

    • DOI

      10.1038/onc.2012.68

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Vasohibin-2 expressed in human serous ovarian adenocarcinoma accelerates tumor growth by promoting angiogenesis2012

    • Author(s)
      Takahashi Y
    • Journal Title

      Mol. Cancer Res

      Volume: 710 Issue: 9 Pages: 1135-1146

    • DOI

      10.1158/1541-7786.mcr-12-0098-t

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Inhibition of PAI-1 induces neutrophil-driven neoangiogenesis and promotes tissue regeneration via production of angiocrine factors in mice2012

    • Author(s)
      Yoshihiko Tashiro, Chiemi Nishida, Kaori Sato-Kusubata, Makiko Ohki-Koizumi, Makoto Ishihara, Aki Sato, Ismael Gritli, Hiromitsu Komiyama, Yayoi Sato, Takashi Dan, Toshio Miyata, Ko Okumura, Yuichi Tomiki, Kazuhiro Sakamoto, Hiromitsu Nakauchi, Beate Heissig, and Koichi Hattori.
    • Journal Title

      Blood

      Volume: 119 Issue: 26 Pages: 6382-6393

    • DOI

      10.1182/blood-2011-12-399659

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] In vivo imaging of brain ischemia using an oxygen-dependent degradative fusion prote in probe2012

    • Author(s)
      Fujita Y, Kuchimaru T、Kadonosono T, Tanaka S, Hase Y, Tomimoto H, Hiraoka M, Kizaka-Kondoh S, Ihara M, Takahashi R
    • Journal Title

      PLoS ONE

      Volume: 7 Issue: 10 Pages: e48051-e48051

    • DOI

      10.1371/journal.pone.0048051

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Protein Kinase A Determines Timing of Early Differentiation through Epigenetic Regulation with G9a2012

    • Author(s)
      Yamamizu K, Fujihara M, Tachibana M, Katayama S, Takahashi A, Hara E, Imai H, Shinkai Y, and Yamashita JK
    • Journal Title

      Cell Stem Cell

      Volume: 10 Issue: 6 Pages: 759-770

    • DOI

      10.1016/j.stem.2012.02.022

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Therapeutic effect of local administration of low-dose simvastatin-conjugated gelatin hydrogel for fracture healing2012

    • Author(s)
      Fukui T
    • Journal Title

      J Bone Miner Res

      Volume: 27 Issue: 5 Pages: 1118-1131

    • DOI

      10.1002/jbmr.1558

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Plasminogen deficiency attenuates postnatal erythropoiesis in male C57BL/6 mice through decreased activity of the LH-testosterone axis2012

    • Author(s)
      Okaji Y, Tashiro Y, Gritli I, Nishida C, Sato A, Ueno Y, Del Canto Gonzalez S, Ohki-Koizumi M, Akiyama H, Nakauchi H
    • Journal Title

      Experimental hematology

      Volume: 40 Issue: 2 Pages: 143-154

    • DOI

      10.1016/j.exphem.2011.10.008

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] DNA damage signaling triggers degradation of histone methyltransferases through APC/C(Cdh1) in senescent cells2012

    • Author(s)
      Akiko Takahashi
    • Journal Title

      Molecular Cell

      Volume: 45 Issue: 1 Pages: 123-131

    • DOI

      10.1016/j.molcel.2011.10.018

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] TGF-β derives epithelial-mesenchymal transition through δEF1-mediated downregulation of ESRP2011

    • Author(s)
      堀口華奈
    • Journal Title

      Oncogene

      Volume: (掲載確定)(印刷中) Issue: 26 Pages: 3190-3201

    • DOI

      10.1038/onc.2011.493

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A member of the ETS family, EHF, and the ATPase RUVBL1 inhibit p53-mediated apoptosis.2011

    • Author(s)
      Taniue K. et al.
    • Journal Title

      EMBO Rep.

      Volume: 12 Issue: 7 Pages: 682-689

    • DOI

      10.1038/embor.2011.81

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prevention of hematogenous metastasis by neutralizing mice and its chimeric anti-Aggrus/podoplanin antibodies2011

    • Author(s)
      Nakazawa Y, Fujita N, et al
    • Journal Title

      Cancer Science

      Volume: 102 Issue: 11 Pages: 2051

    • DOI

      10.1111/j.1349-7006.2011.02058.x

    • NAID

      10030245233

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification and characterization of a resident vascular stem/ progenitor cell population in preexisting blood vessels2011

    • Author(s)
      Naito H, Kidoya H, Sakimoto S, Wakabayashi T, Takakura N
    • Journal Title

      EMBO J.

      Volume: 31 Issue: 4 Pages: 842-855

    • DOI

      10.1038/emboj.2011.465

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The EGFR ligands amphiregulin and heparin-binding EGF-like growth factor promote peritoneal carcinomatosis in CXCR4-expressing gastric cancer2011

    • Author(s)
      Yasumoto K, Yamada T, Kawashima A, Wang W, Li Q, Donev IS, Takeuchi S, Mouri H, Yamashita K, Ohtsubo K, Yano S.
    • Journal Title

      Clin Cancer Res

      Volume: 17 Issue: 11 Pages: 3619-30

    • DOI

      10.1158/1078-0432.ccr-10-2475

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Detection of the onset of ischemia and carcinogenesis by hypoxia-inducible transcription factor-based in vivo bioluminescence imaging2011

    • Author(s)
      Kadonosono T, Kuchimaru T, Yamada S, Takahashi Y. Murakami A, Watanabe H, Tani T, Inoue M, Tsukamoto T, Toyoda T, Tanaka T, Hirota K, Urano K, Machida K, Eto T, Ogura T, Tsutsumi H, Ito M, Hiraoka M, Kondoh G, Kizaka-Kondoh S
    • Journal Title

      PLoS ONE

      Volume: 6(11) Issue: 11 Pages: e26640-e26640

    • DOI

      10.1371/journal.pone.0026640

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Enhancement of ectopic osteoid formation following the dual release of bone morphogenetic protein-2 and Wnt1 inducible signaling pathway protein 1 from gelatin sponges2011

    • Author(s)
      Kohara, H., Tabata, Y.
    • Journal Title

      Biomaterials

      Volume: 32 Issue: 24 Pages: 5726-5732

    • DOI

      10.1016/j.biomaterials.2011.04.035

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Activation of Bmp2-Smad1 signal and its regulation by coordinated alteration of H3K27 trimethylation in Ras-induced senescence2011

    • Author(s)
      Kaneda A, Fujita T, Anai M, Yamamoto S,Nagae G, Morikawa M, Tsuji S, Oshima M,Miyazono K, Aburatani H
    • Journal Title

      PLoS Genetics

      Volume: 7 Issue: 11 Pages: e1002359-e1002359

    • DOI

      10.1371/journal.pgen.1002359

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Epigenetically coordinated GATAT2 binding is necessary for endothelium-specific endomucin expression2011

    • Author(s)
      Kanki Y, Kohro T, Jiang S, Tsutsumi S, Mimura I, Suehiro J, Wada Y, Ohta Y, Ihara S, Iwanari H, Naito M, Hamakubo T, Aburatani H, Kodama T, Minami T
    • Journal Title

      EMBO J

      Volume: 30 Issue: 13 Pages: 2582-95

    • DOI

      10.1038/emboj.2011.173

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] TGF-β regulates isoform switching of FGF receptors and epithelial-mesenchymal transition.2011

    • Author(s)
      Shirakihara T, Miyazono K, et al.
    • Journal Title

      EMBO Journal

      Volume: 30 Pages: 783-795

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Genome-wide approaches reveal functional IL-4 inducible STAT6 binding to the vascular cell adhesion molecule-1 promoter.2011

    • Author(s)
      Tozawa H, Minami T, et al.
    • Journal Title

      Molecular and Cellular Biology

      Volume: (掲載確定(印刷中))

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The novel metastasis promoter Merm1/Wbscr22 enhances tumor cell survival in the vasculature by suppressing Zac1/p53-dependent apoptosis.2011

    • Author(s)
      Nakazawa Y, Fujita N, et al.
    • Journal Title

      Cancer Research

      Volume: 71 Pages: 1146-1155

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Transient PI3K inhibition induces apoptosis and overcomes HGF-mediated resistance to EGFR-TKIs in EGFR mutant lung cancer.2011

    • Author(s)
      Donev IS, Yano S, et al.
    • Journal Title

      Clinical Cancer Research

      Volume: (掲載確定(印刷中))

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Sunspot, a link between Wingless signaling and endoreplication in Drosophila.2010

    • Author(s)
      Taniue K, Akiyama T, et al.
    • Journal Title

      Development

      Volume: 137 Pages: 1755-1764

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Apelin induces enlarged and nonleaky blood vessels for functional recovery from ischemia.2010

    • Author(s)
      Kidoya H, Takakura N, et al.
    • Journal Title

      Blood

      Volume: 115 Pages: 3166-3174

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Isolation of a small vasohibin-binding protein (SVBP) and its role in vasohibin secretion.2010

    • Author(s)
      Suzuki Y, Sato Y, et al.
    • Journal Title

      Journal of Cell Science

      Volume: 123 Pages: 3094-4101

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Adipocyte-derived microvesicles are associated with multiple angiogenic factors and induce angiogenesis in vivo and in vitro.2010

    • Author(s)
      Aoki N, Heissig, B, et al.
    • Journal Title

      Endocrinology

      Volume: 151 Pages: 2567-2576

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] In vivo imaging of HIF-active rumors by an oxygen-dependent degradation protein probe with an interchangeable labeling system.2010

    • Author(s)
      Kuchimaru T, Kizaka-Kondoh S, et al.
    • Journal Title

      PLoS One

      Volume: 5

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] Regulation of the progression of lung cancer by TGF-beta2015

    • Author(s)
      Miyazono K.
    • Organizer
      FASEB Scientific Research Conference: The TGF-Beta Superfamily: Signaling in Development and Disease
    • Place of Presentation
      Base Village Conference Center (Snowmass, CO, USA)
    • Year and Date
      2015-07-12
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] The Arkadia-ESRP2 axis suppresses tumor progression: Analyses in clear cell renal cell carcinoma2015

    • Author(s)
      Mizutani A, Koinuma D, Seimiya H, Miyazono K
    • Organizer
      AACR Annual Meeting 2015
    • Place of Presentation
      Pennsylvania Convention Center (Philadelphia, PA, USA)
    • Year and Date
      2015-04-18
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] リンパ管形成におけるTGF-βファミリーシグナルの役割2015

    • Author(s)
      吉松康裕、Yulia G Lee、赤津裕一、田口瑠奈、鈴木洋、Sara I Cunha、鈴木夕佳、山崎智子、桂彰宏、森下保幸、S Paul Oh、Teresa A Zimmers、Se-Jin Lee、Kristian Pietras、Gou Young Koh、渡部徹郎、宮園浩平
    • Organizer
      がん研究分野の特性等を踏まえた支援活動・公開シンポジウム
    • Place of Presentation
      学術総合センター(東京都千代田区)
    • Year and Date
      2015-01-27 – 2015-01-28
    • Related Report
      2014 Annual Research Report
  • [Presentation] TGF-β signaling inhibitor eradicates chronic myelogenous leukemia stem cells2015

    • Author(s)
      仲 一仁、石原薫理、定免由枝
    • Organizer
      がん研究分野の特性等を踏まえた支援活動・公開シンポジウム
    • Place of Presentation
      学術総合センター(東京都千代田区)
    • Year and Date
      2015-01-27 – 2015-01-28
    • Related Report
      2014 Annual Research Report
  • [Presentation] Roles of the protein tyrosine phosphatase VE-PTP in endothelial cells of tumor vessels and normal their counterparts2015

    • Author(s)
      村田陽二、Kemala Isnainiasih Mantilidewi、森宗昌、小谷武徳、草苅伸也、大西浩史、的崎尚
    • Organizer
      がん研究分野の特性等を踏まえた支援活動・公開シンポジウム
    • Place of Presentation
      学術総合センター(東京都千代田区)
    • Year and Date
      2015-01-27 – 2015-01-28
    • Related Report
      2014 Annual Research Report
  • [Presentation] CMLに対するIFNαの作用における転写因子C/EBPβの関与2015

    • Author(s)
      横田明日美、平位秀世、林嘉宏、田村彰広、佐藤淳至、岩佐磨佐紀、藤城綾、庄司月美、三浦康生、前川平
    • Organizer
      がん研究分野の特性等を踏まえた支援活動・公開シンポジウム
    • Place of Presentation
      学術総合センター(東京都千代田区)
    • Year and Date
      2015-01-27 – 2015-01-28
    • Related Report
      2014 Annual Research Report
  • [Presentation] TGF-βファミリーのがん微小環境に及ぼす作用とがん治療戦略2015

    • Author(s)
      宮園 浩平
    • Organizer
      がん研究分野の特性等を踏まえた支援活動・公開シンポジウム
    • Place of Presentation
      学術総合センター(東京都千代田区)
    • Year and Date
      2015-01-27 – 2015-01-28
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Effect of Hsp90 inhibitor 17-DMAG on ligand-triggered resistance to alectinib in EML4-ALK NSCLC cells2014

    • Author(s)
      Azusa Tanimoto
    • Organizer
      Third AACR-IASLC Joint Conference on the Molecular Origins of Lung Cancer
    • Place of Presentation
      Hard Rock Hotel (San Diego, USA)
    • Related Report
      2013 Annual Research Report
  • [Presentation] DNA damage response and cellular senescence in cancer2013

    • Author(s)
      Eiji Hara
    • Organizer
      9th AACR-JCA joint conference
    • Place of Presentation
      Hyatt Regency Maui (米国、ハワイ)
    • Year and Date
      2013-02-21
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Hypoxia-inducible factor activity is an excellent marker for tumorigenesis and cancer progression2013

    • Author(s)
      Shinae Kizaka-Kondoh
    • Organizer
      9th AACR-JCA joint conference
    • Place of Presentation
      Hyatt Regency Maui (米国、ハワイ)
    • Year and Date
      2013-02-21
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Keynote Presentation: EMT and EndMT induced by TGF-beta2013

    • Author(s)
      Kohei Miyazono
    • Organizer
      UCSF Symposium: Transforming Growth Factor Signaling
    • Place of Presentation
      UCSF (San Francisco, U.S.A.)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] TGF-beta signals in tumor microenvironment and treatment of cancer2013

    • Author(s)
      Kohei Miyazono
    • Organizer
      第72回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜(神奈川)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Obesity-induced gut microbial metabolite promotes liver cancer through senescence secretome2013

    • Author(s)
      Eiji Hara
    • Organizer
      17th International Symposium on Cells of the Hepatic Sinusoid
    • Place of Presentation
      大阪国際会議場(大阪)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Elucidation of the hypoxia-inducible factor involvement in tumorigenesis and metastasis by using mouse models2013

    • Author(s)
      Shinae Kondoh
    • Organizer
      第72回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜(神奈川)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Development of anti-Aggrus/podoplanin antibodies suppressing hematogenous metastasis and tumor growth in vivo2013

    • Author(s)
      Naoya Fujita
    • Organizer
      第72回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜(神奈川)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Vascular niche and stem cell regulation2013

    • Author(s)
      Nobuyuki Takakura
    • Organizer
      第72回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜(神奈川)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Resistance to EGFR TKIs2013

    • Author(s)
      Seiji Yano
    • Organizer
      IASLC 15th World Conference on Lung Cancer
    • Place of Presentation
      Convention & Exhibition Centre (Sydney, Australia)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Role of 5-hydroxymethylcytosine in the tumorigenicity of glioblastoma cells2013

    • Author(s)
      Hiroki Takai, Tetsu Akiyama
    • Organizer
      第72回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜(神奈川)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 大腸がんの造腫瘍性に関与する新規long ncRNAの機能解析2012

    • Author(s)
      谷上 賢瑞
    • Organizer
      日本分子生物学会
    • Place of Presentation
      福岡国際会議場(福岡)
    • Year and Date
      2012-12-12
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Tumor promotive and suppressive function of TGF-beta2012

    • Author(s)
      Kohei Miyazono
    • Organizer
      The 43rd International Symposium of the Princess Takamatsu Cancer Research Fund
    • Place of Presentation
      ホテルグランドパレス(東京)
    • Year and Date
      2012-11-14
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Targeting tumor-host interaction for developing anti-metastatic therapies2012

    • Author(s)
      Naoya Fujita
    • Organizer
      JST CREST/SICP/ERATO Joint Symposium on " Microfluidics for Tissue and Cell Applications
    • Place of Presentation
      東京大学生産技術研究所(東京)
    • Year and Date
      2012-11-05
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] The role of vasohibin family in cancers2012

    • Author(s)
      Yasufumi Sato
    • Organizer
      第71回日本癌学会学術総会 (English Session)
    • Place of Presentation
      ロイトン札幌(札幌)
    • Year and Date
      2012-09-19
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Ligand-stimulated receptor activation as novel targets to overcome resistance to molecular targeted drugs in lung cancer2012

    • Author(s)
      矢野聖二
    • Organizer
      第71回日本癌学会学術集会
    • Place of Presentation
      ロイトン札幌(札幌)
    • Year and Date
      2012-09-19
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Requirement of endothelial stem-like cells and Tie2-APJ axis for mature blood vessel formation2012

    • Author(s)
      Nobuyuki Takakura
    • Organizer
      The International Vascular Biology Meeting (IVBM)2012
    • Place of Presentation
      Rhein-Main-Hallen(ドイツ)
    • Year and Date
      2012-06-02
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 腫瘍血管新生制御の分子基盤2012

    • Author(s)
      佐藤靖史
    • Organizer
      千里ライフサイエンスセミナー「がんの転移・浸潤と微小環境」
    • Place of Presentation
      千里ライフサイエンスセンタービル(大阪府豊中市)(招待講演)
    • Year and Date
      2012-02-24
    • Related Report
      2011 Annual Research Report
  • [Presentation] がん幹細胞とそれを支持する血管ニッチ2012

    • Author(s)
      高倉伸幸
    • Organizer
      千里ライフサイエンスセミナー「がんの転移・浸潤と微小環境」
    • Place of Presentation
      千里ライフサイエンスセンタービル(大阪府豊中市)(招待講演)
    • Year and Date
      2012-02-24
    • Related Report
      2011 Annual Research Report
  • [Presentation] 腫瘍の低酸素環境応答とその可視化2012

    • Author(s)
      近藤科江
    • Organizer
      千里ライフサイエンスセミナー「がんの転移・浸潤と微小環境」
    • Place of Presentation
      千里ライフサイエンスセンタービル(大阪府豊中市)(招待講演)
    • Year and Date
      2012-02-24
    • Related Report
      2011 Annual Research Report
  • [Presentation] 腫瘍微小循環の機能的破綻2012

    • Author(s)
      宮園浩平
    • Organizer
      千里ライフサイエンスセミナー「がんの転移・浸潤と微小環境」
    • Place of Presentation
      千里ライフサイエンスセンタービル(大阪府豊中市)(招待講演)
    • Year and Date
      2012-02-24
    • Related Report
      2011 Annual Research Report
  • [Presentation] がん細胞の環境応答-臨床的立場から2012

    • Author(s)
      矢野聖二
    • Organizer
      千里ライブサイエンスセミナー「がんの転移・浸潤と微小環境」
    • Place of Presentation
      千里ライフサイエンスセンタービル(大阪府豊中市)(招待講演)
    • Year and Date
      2012-02-24
    • Related Report
      2011 Annual Research Report
  • [Presentation] TGF-beta, EMT, and TGF-beta signaling inhibitors in cancer progression2011

    • Author(s)
      Kohei Miyazono
    • Organizer
      Keystone symposia : Epithelial plasticity and epithelial to mesenchymal transition
    • Place of Presentation
      Fairmont Waterfront(カナダ、バンクーバー)
    • Year and Date
      2011-01-25
    • Related Report
      2010 Annual Research Report
  • [Presentation] がん細胞とこれを取り巻く細胞・新しいがん治療の試み(市民公開講座)2010

    • Author(s)
      宮園浩平
    • Organizer
      第33回日本分子生物学会年会・第83回日本生化学会大会・合同年会
    • Place of Presentation
      東京大学安田講堂(東京都文京区)
    • Year and Date
      2010-12-11
    • Related Report
      2010 Annual Research Report
  • [Presentation] Roles of TGF-beta signaling in cancer(大会長企画シンポジウム)2010

    • Author(s)
      Kohei Miyazono
    • Organizer
      第33回日本分子生物学会年会・第83回日本生化学会大会・合同年会
    • Place of Presentation
      神戸ポートアイランド(兵庫県神戸市)
    • Year and Date
      2010-12-09
    • Related Report
      2010 Annual Research Report
  • [Presentation] Tissue specific gene expression, insights from the genome-wide and epigenetical analysis in vitro and in vivo(シンポジウム)2010

    • Author(s)
      南敬
    • Organizer
      第18回日本血管生物医学会学術集会
    • Place of Presentation
      梅田スカイビル(大阪府大阪市)
    • Year and Date
      2010-12-01
    • Related Report
      2010 Annual Research Report
  • [Presentation] がんハイポキシアの生体イメージング(モーニングレクチャー)2010

    • Author(s)
      近藤科江
    • Organizer
      第69回日本癌学会学術総会
    • Place of Presentation
      大阪国際コンベンションセンター(大阪府大阪市)
    • Year and Date
      2010-09-24
    • Related Report
      2010 Annual Research Report
  • [Presentation] がん幹細胞と血管ニッチ(モーニングレクチャー)2010

    • Author(s)
      高倉伸幸
    • Organizer
      第69回日本癌学会学術総会
    • Place of Presentation
      大阪国際コンベンションセンター(大阪府大阪市)
    • Year and Date
      2010-09-24
    • Related Report
      2010 Annual Research Report
  • [Presentation] 癌増殖における線維素溶解系因子の役割と新規治療法の開発2010

    • Author(s)
      石原誠人、Beate Heissig, ほか
    • Organizer
      第69回日本癌学会学術総会
    • Place of Presentation
      大阪国際コンベンションセンター(大阪府大阪市)
    • Year and Date
      2010-09-24
    • Related Report
      2010 Annual Research Report
  • [Presentation] EGFR変異肺がんのチロシンキナーゼ阻害薬耐性と治療戦略(シンポジウム)2010

    • Author(s)
      矢野聖二
    • Organizer
      第69回日本癌学会学術総会
    • Place of Presentation
      大阪国際コンベンションセンター(大阪府大阪市)
    • Year and Date
      2010-09-23
    • Related Report
      2010 Annual Research Report
  • [Presentation] 血管新生抑制とがん(モーニングレクチャー)2010

    • Author(s)
      佐藤靖史
    • Organizer
      第69回日本癌学会学術総会
    • Place of Presentation
      大阪国際コンベンションセンター(大阪府大阪市)
    • Year and Date
      2010-09-23
    • Related Report
      2010 Annual Research Report
  • [Presentation] TGF-βシグナルのがん幹細胞と微小環境における役割(日本癌学会-アメリカ癌学会合同シンポジウム)2010

    • Author(s)
      宮園浩平
    • Organizer
      第69回日本癌学会学術総会
    • Place of Presentation
      大阪国際コンベンションセンター(大阪府大阪市)
    • Year and Date
      2010-09-22
    • Related Report
      2010 Annual Research Report
  • [Presentation] 抗がん剤耐性機構の解明とその克服(がん研究入門コース)2010

    • Author(s)
      藤田直也
    • Organizer
      第69回日本癌学会学術総会
    • Place of Presentation
      大阪国際コンベンションセンター(大阪府大阪市)
    • Year and Date
      2010-09-22
    • Related Report
      2010 Annual Research Report
  • [Presentation] 膠芽腫幹細胞におけるcyclin D2の重要な役割(English workshop)2010

    • Author(s)
      那須亮、秋山徹, ほか
    • Organizer
      第69回日本癌学会学術総会
    • Place of Presentation
      大阪国際コンベンションセンター(大阪府大阪市)
    • Year and Date
      2010-09-22
    • Related Report
      2010 Annual Research Report
  • [Remarks] がん微小環境ネットワークの統合的研究

    • URL

      http://cancer-microenvironment.jp/index.html

    • Related Report
      2015 Annual Research Report
  • [Remarks] 文部科学省科学研究費補助金「新学術領域研究(研究領域提案型)」がん微小環境ネットワークの統合的研究

    • URL

      http://cancer-microenvironment.jp/index.html

    • Related Report
      2014 Annual Research Report
  • [Remarks] 東京大学大学院医学系研究科病因・病理学専攻分子病理学分野

    • URL

      http://beta-lab.umin.ac.jp/

    • Related Report
      2014 Annual Research Report
  • [Remarks] 文部科学省科学研究費補助金「新学術領域研究(研究領域提案型)」がん微小環境ネットワークの統合的研究

    • URL

      http://cancer-microenvironment.jp/index.html

    • Related Report
      2013 Annual Research Report
  • [Remarks] 文部科学省科学研究費補助金「新学術領域研究(研究領域提案型)」がん微小環境ネットワークの統合的研究

    • URL

      http://cancer-microenvironment.jp/

    • Related Report
      2012 Annual Research Report
  • [Remarks]

    • URL

      http://cancer-microenvironment.jp/index.html

    • Related Report
      2011 Annual Research Report
  • [Remarks]

    • URL

      http://cancer-microenvironment.jp/

    • Related Report
      2010 Annual Research Report
  • [Funded Workshop] International Symposium: Integrative Research on Cancer Microenvironment Network2015

    • Place of Presentation
      東京大学小柴ホール(東京都・文京区)
    • Year and Date
      2015-09-11
    • Related Report
      2015 Annual Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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