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New aspect of the ubiquitin system : its enormous roles in protein regulation

Organizer

Project AreaNew aspect of the ubiquitin system : its enormous roles in protein regulation
Project/Area Number 24112001
Research Category

Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

Allocation TypeSingle-year Grants
Review Section Biological Sciences
Research InstitutionKyoto University

Principal Investigator

IWAI Kazuhiro  京都大学, 医学研究科, 教授 (60252459)

Co-Investigator(Kenkyū-buntansha) 駒田 雅之  東京工業大学, 生命理工学研究科, 教授 (10225568)
嘉村 巧  名古屋大学, 理学(系)研究科(研究院), 教授 (40333455)
佐伯 泰  公益財団法人東京都医学総合研究所, その他部局等, その他 (80462779)
Project Period (FY) 2012-06-28 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥47,970,000 (Direct Cost: ¥36,900,000、Indirect Cost: ¥11,070,000)
Fiscal Year 2016: ¥9,360,000 (Direct Cost: ¥7,200,000、Indirect Cost: ¥2,160,000)
Fiscal Year 2015: ¥9,360,000 (Direct Cost: ¥7,200,000、Indirect Cost: ¥2,160,000)
Fiscal Year 2014: ¥13,130,000 (Direct Cost: ¥10,100,000、Indirect Cost: ¥3,030,000)
Fiscal Year 2013: ¥9,360,000 (Direct Cost: ¥7,200,000、Indirect Cost: ¥2,160,000)
Fiscal Year 2012: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000)
Keywords領域内研究者交流 / 情報交換 / 若手支援 / 国際化推進 / 研究技法共有 / 生体分子 / ユビキチン / タンパク質 / 翻訳後修飾
Outline of Final Research Achievements

Ubiquitin, a proteinous post-translational modifier, has been studied as a part of protein degradation system. However, it is now widely recognized that the ubiquitin system is involved in the regulation of a wide variety of biological phenomena by modulating protein functions in many ways. Since dissection methods of the ubiquitin system become diversified and highly developed, it is almost impossible to do all the dissections in one laboratory. “New aspect of the ubiquitin system : its enormous roles in protein regulation”, an research area of Grant-in-Aid for Scientific Research on Innovative Areas was organized to develop cutting-edge technologies to dissect the ubiquitin system and tried to identify new roles of the ubiquitin system in the regulation of biological phenomena. This research project is a headquarter of the research area and handled advertisement, organizing conference for young as well as foreign researchers and promoting collaborations within research areas.

Report

(6 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Annual Research Report
  • 2014 Annual Research Report
  • 2013 Annual Research Report
  • 2012 Annual Research Report

Research Products

(41 results)

All 2016 2015 2014 2013 2012 Other

All Journal Article (22 results) (of which Acknowledgement Compliant: 8 results,  Peer Reviewed: 19 results,  Open Access: 6 results) Presentation (14 results) (of which Int'l Joint Research: 2 results,  Invited: 12 results) Remarks (4 results) Funded Workshop (1 results)

  • [Journal Article] Roles of the NF-κB pathway in B-lymphocyte biology.2016

    • Author(s)
      Sasaki, Y. and Iwai, K.
    • Journal Title

      Curr. Top. Microbiol. Immunol.

      Volume: 393 Pages: 177-209

    • DOI

      10.1007/82_2015_479

    • Related Report
      2016 Annual Research Report
  • [Journal Article] Immunoblot Analysis of Linear Polyubiquitination of NEMO.2015

    • Author(s)
      Sasaki, Y., Fujita, H., Nakai, M., and Iwai, K.
    • Journal Title

      Methods. Mol. Biol.

      Volume: 1280 Pages: 297-309

    • DOI

      10.1007/978-1-4939-2422-6_17

    • Related Report
      2015 Annual Research Report
    • Acknowledgement Compliant
  • [Journal Article] Roles of linear ubiquitinylation, a crucial regulator of NF-κB and cell death, in the immune system.2015

    • Author(s)
      Sasaki, K. and Iwai, K.
    • Journal Title

      Immunol. Rev.

      Volume: 266 Pages: 175-189

    • DOI

      10.1111/imr.12308

    • NAID

      120005672572

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The unexpected role of polyubiquitin chains in the formation of fibrillar aggregates2015

    • Author(s)
      Morimoto, D., Walinda, E. Fukada, H., Sou, Y. S., Kageyama, S., Hoshino, M., Fujii, T., Tsuchiya, H., Saeki, Y., Arita, K., Ariyoshi, M., Tochio, H., Iwai, K., Namba, K., Komatsu, M., Tanaka, K., and Shirakawa M.
    • Journal Title

      Nat Commun.

      Volume: 6 Pages: 000-000

    • DOI

      10.1038/ncomms7116

    • NAID

      120005528125

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Gliotoxin Suppresses NF-kappaB Activation by Selectively Inhibiting Linear Ubiquitin Chain Assembly Complex (LUBAC)2015

    • Author(s)
      Hiroki Sakamoto, Shinichiro Egashira, Nae Saito, Takayoshi Kirisako, Simon Miller, Yoshiteru Sasaki, Tadahiko Matsumoto, Manabu Shimonishi, Toru Komatsu, Takuya Terai, Tasuku Ueno, Kenjiro Hanaoka, Hirotatsu Kojima, Takayoshi Okabe, Soichi Wakatsuki, Kazuhiro Iwai, Tetsuo Nagano
    • Journal Title

      ACS Chem. Biol.

      Volume: 10 Pages: 675-681

    • DOI

      10.1021/cb500653y

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Phenotypic complementation of genetic immunodeficiency by chronic herpesvirus infection.2015

    • Author(s)
      MacDuff, D. A., Reese, T. A,, Kimmey, J. M., Weiss, L. A., Song, C., Zhang, X., Kambal, A., Duan, E., Carrero, J. A., Boisson, B., Laplantine, E., Israel, A., Picard, C., Colonna, M., Edelson, B. T., Sibley, L. D., Stallings, C. L., Casanova, J. L., Iwai, K., Virgin, H. W.
    • Journal Title

      eLife

      Volume: 4

    • DOI

      10.7554/elife.04494

    • NAID

      120005997705

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] IFN-γ or IFN-α ameliorates chronic proliferative dermatitis by inducing expression of linear ubiquitin chain assembly complex.2014

    • Author(s)
      Tamiya H, Terao M, Takiuchi T, Nakahara M, Sasaki Y, Katayama I, Yoshikawa H, and Iwai K.
    • Journal Title

      Journal of Immunology.

      Volume: 192 Pages: 3793-3804

    • DOI

      10.4049/jimmunol.1302308

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] The linear ubiquitin assembly complex (LUBAC) is essential for NLRP3 inflammasome activation.2014

    • Author(s)
      Rodgers, M. A., Bowman, J., Fujita, H., Orazio, N., Shi, M., Liang, Q., Amatya, R., Kelly, T. J., Iwai, K., Ting, J., and Jung, J. U.
    • Journal Title

      J. Exp. Med.

      Volume: 211 Pages: 1333-1347

    • DOI

      10.1084/jem.20132486

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] HOIL-1L Functions as the PKCζ Ubiquitin Ligase to Promote Lung Tumor Growth.2014

    • Author(s)
      Queisser, M. A., Dada, L. A., Deiss-Yehiely, N., Angulo, M., Zhou, G., Kouri, F. M., Knab, L. M., Liu, J., Stegh, A. H., DeCamp, M. M., Budinger, G. R., Chandel, N. S., Ciechanover, A., Iwai, K., and Sznajder, J. I.
    • Journal Title

      Am. J. Respir. Crit. Care Med.

      Volume: 190 Pages: 688-698

    • DOI

      10.1164/rccm.201403-0463oc

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Linear ubiquitin chains: NF-κB signalling, cell death, and beyond.2014

    • Author(s)
      Iwai, K., Fujita, H., and Sasaki, Y.
    • Journal Title

      Nat. Rev. Mol. Cell Biol.

      Volume: 15 Pages: 503-508

    • DOI

      10.1038/nrm3836

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Ubiquitin chain elongation: An intriguing strategy.2014

    • Author(s)
      Iwai, K. and Tanaka, K.
    • Journal Title

      Molecular Cell

      Volume: 56

    • DOI

      10.1016/j.molcel.2014.10.009

    • Related Report
      2014 Annual Research Report
  • [Journal Article] Suppression of LUBAC-mediated linear ubiquitination by a specific interaction between LUBAC and the deubiquitinases CYLD and OTULIN.2014

    • Author(s)
      Takiuchi, T., Nakagawa, T., Tamiya, H., Fujita, H., Sasaki, Y., Saeki, Y., Takeda, H., Sawasaki, T., Buchberger, A., Kimura, T., and Iwai. K.
    • Journal Title

      Genes Cells

      Volume: 19 Pages: 254-272

    • DOI

      10.1111/gtc.12128

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Mechanism underlying IKK activation mediated by the linear ubiquitin chain assembly complex (LUBAC).2014

    • Author(s)
      Fujita, H., Rahighi, S., Akita, M., Kato, R., Sasaki, Y., Wakatsuki, S., and Iwai, K.
    • Journal Title

      Mol Cell Biol.

      Volume: 34 Pages: 1322-1335

    • DOI

      10.1128/mcb.01538-13

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Essential role of the linear ubiquitin chain assembly complex in lymphoma revealed by rare germline polymorphisms.2014

    • Author(s)
      Yang, Y., Schmitz, R., et al.
    • Journal Title

      Cancer Discov.

      Volume: 4 Pages: 480-493

    • DOI

      10.1158/2159-8290.cd-13-0915

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Defective immune responses in mice lacking LUBAC-mediated linear ubiquitination in B cells2013

    • Author(s)
      Sasaki, Y., Sano, S., Nakahara, M., Murata, S., Kometani, K., Aiba, Y., Sakamoto, S., Watanabe, Y., Tanaka, K., Kurosaki, T., and lwai, K.
    • Journal Title

      EMBO J

      Volume: 32 Pages: 2463-2476

    • DOI

      10.1038/emboj.2013.184

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Recruitment of the autophagic machinery to endosomes during infection is mediated by ubiquitin2013

    • Author(s)
      Naonobu Fujita et al.
    • Journal Title

      J Cell Biol

      Volume: 203 Pages: 115-128

    • DOI

      10.1083/jcb.201304188

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Two coordinated mechanisms underlie TNFα-induced immediate and delayed IKK activation.2013

    • Author(s)
      Blackwell, K., Zhang, L., Workman, L.M., Ting, A.T., Iwai, K., Habelhah, H.
    • Journal Title

      Mol. Cell. Biol.

      Volume: 33 Pages: 1901-1915

    • DOI

      10.1128/mcb.01416-12

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] IOP1 protein is an external component of the human cytosolic iron-sulfur cluster assembly (CIA) machinery and functions in the MMS19 protein-dependent CIA pathway2013

    • Author(s)
      Mineaki Seki, Yukiko Takeda, Kazuhiro Iwai and Kiyoji Tanaka
    • Journal Title

      J. Biol. Chem.

      Volume: 288 Pages: 16680-16689

    • DOI

      10.1074/jbc.m112.416602

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Specific recognition of linear polyubiquitin by A20 zinc finger 7 is involved in NF-κB regulation2012

    • Author(s)
      Tokunaga F, Nishimasu H, Ishitani R, Goto E, Noguchi T, Mio K, Kamei K, Ma A, Iwai K, Nureki O
    • Journal Title

      EMBO J

      Volume: 31 Pages: 3856-3856

    • DOI

      10.1038/emboj.2012.241

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Linear ubiquitination of NEMO negatively regulates the interferon antiviral response through disruption of the MAVS-TRAF3 complex.2012

    • Author(s)
      Belgnaoui, SM.
    • Journal Title

      Cell Host Microbe.

      Volume: 12 Pages: 211-222

    • DOI

      10.1016/j.chom.2012.06.009

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Analysis of nuclear factor-κB (NF-κB) essential modulator (NEMO) binding to linear and lysine-linked ubiquitin chains and its role in the activation of NF-κB.2012

    • Author(s)
      Kensche, T.
    • Journal Title

      J. Biol. Chem

      Volume: 287 Pages: 23626-23634

    • DOI

      10.1074/jbc.m112.347195

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Diverse ubiquitin signaling in NF-κB activation.2012

    • Author(s)
      Iwai, K.
    • Journal Title

      Trends Cell Biol.

      Volume: 22 Pages: 355-364

    • DOI

      10.1016/j.tcb.2012.04.001

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Presentation] Pathophysiology of the atypical linear ubiquitin chain2016

    • Author(s)
      Iwai, K
    • Organizer
      Diverse functions of Ubiquitin : Degradation, Signaling, and Beyond
    • Place of Presentation
      Kyoto Japan
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Patho-physiological functions of a new type of ubiquitin modification, linear ubiquitination.2015

    • Author(s)
      Iwai, K.
    • Organizer
      LLS Lecture, Northwestern University, Feinberg School of Medicine.
    • Place of Presentation
      Chicago, IL, USA.
    • Year and Date
      2015-10-13
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Linear ubiquitin chains: a new regulator of NF-κB activation and cell death signaling.2015

    • Author(s)
      Iwai, K.
    • Organizer
      1st SPS International Symposium Xiamen University
    • Place of Presentation
      Xiamen, China
    • Year and Date
      2015-06-13
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Phenotypical difference between mice lacking subunits of LUBAC ubiquitin ligase.2014

    • Author(s)
      Iwai, K.
    • Organizer
      1st International Symposium for New Aspects of the Ubiquitin Research
    • Place of Presentation
      Kyoto, Japan
    • Year and Date
      2014-11-10
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Mechanism underlying linear ubiquitin-mediated NF-κB activation.2014

    • Author(s)
      Iwai, K.
    • Organizer
      Benzon Symposium Nuclear regulation by ubiquitin
    • Place of Presentation
      Copenhagen, Denmark
    • Year and Date
      2014-08-18 – 2014-08-21
    • Related Report
      2014 Annual Research Report
  • [Presentation] Linear ubiquitination : a new regulator of NF-κB and cell death signaling.2014

    • Author(s)
      Iwai, K.
    • Organizer
      2014 International Conference on Protein Metabolism & Diseases
    • Place of Presentation
      Yangyang, Korea
    • Year and Date
      2014-07-09 – 2014-07-11
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Molecular mechanism and regulation of linear chain-mediated NF-κB activation.2014

    • Author(s)
      Fujita, H., Takiuchi, T., and Iwai, K.
    • Organizer
      Cold Spring Harbor Asia Conference “ Protein Modifications & Homeostasis”
    • Place of Presentation
      Suzhou, China
    • Year and Date
      2014-06-16 – 2014-06-20
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Linear Polyubiquitination: a Crucial Regulator of NF-κB Activation.2014

    • Author(s)
      Iwai, K.
    • Organizer
      THE UEHARA MEMORIAL FOUNDATION SYMPOSIUM 2014, Innovative Medicine : Basic Research and Development.
    • Place of Presentation
      Tokyo, Japan
    • Year and Date
      2014-06-14 – 2014-06-17
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Differential requirement of LUBAC-mediated linear polyubiquitination in CD40- or BCR-mediated canonical NF-κB activation in B cells2013

    • Author(s)
      Sasaki, Y., Fujita, H., and Iwai, K.
    • Organizer
      The EMBO Conference “Ubiquitin and Ubiquitin-like Proteins: From structure to function”
    • Place of Presentation
      Riva del Garda, Italy
    • Year and Date
      2013-10-01 – 2013-10-05
    • Related Report
      2013 Annual Research Report
  • [Presentation] Linear polyubiquitination: a new regulator of NF-κB activation.2013

    • Author(s)
      Iwai, K.
    • Organizer
      The 35th Naito Conference “The Ubiquitin-Proteasome System: From Basic Mechanisms to Pathophysiological Roles”
    • Place of Presentation
      Sapporo, Japan
    • Year and Date
      2013-07-09 – 2013-07-12
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Linear polyubiquitination: a new regulator of NF-κB activation.2013

    • Author(s)
      Iwai, K.
    • Organizer
      The 38th FEBS congress symposium “Regulation of biological processes by ubiquitin and ubiquitin-like proteins in health and disease: proteolysis, autophagy and apoptosis”
    • Place of Presentation
      St. Petersburg, Russia
    • Year and Date
      2013-07-06 – 2013-07-12
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Linear polyubiquitination : A crucial regulator of NF-kB signaling2012

    • Author(s)
      Iwai, K.
    • Organizer
      The 3rd International Symposium "Signaling and Regulation in the Immune and Nervous Systems
    • Place of Presentation
      Magdeburg, Germany
    • Year and Date
      2012-11-22
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Linear polyubiquitination: A crucial regulator of NF-κB signalling2012

    • Author(s)
      Fujita, H.
    • Organizer
      ZOMESVII conference
    • Place of Presentation
      Munich Germany
    • Year and Date
      2012-09-18
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Mechanism underlying generation of linear polyubiquitin chains2012

    • Author(s)
      Iwai, K
    • Organizer
      4th Annual Ubiquitin Drug Discovery Diagnostics Conference 2012
    • Place of Presentation
      Philadelphia, USA
    • Year and Date
      2012-07-23
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Remarks] 新学術領域 「ユビキチンネオバイオロジー:拡大するタンパク質制御システム」

    • URL

      http://ubiquitin.jp/

    • Related Report
      2016 Annual Research Report
  • [Remarks] 新学術領域【ユビキチンネオバイオロジー」拡大するタンパク質制御システム

    • URL

      http://ubiquitin.jp/

    • Related Report
      2015 Annual Research Report
  • [Remarks] 新学術領域研究 ユビキチンネオバイオロジー:拡大するタンパク質制御システム

    • URL

      http://ubiquitin.jp/

    • Related Report
      2014 Annual Research Report
  • [Remarks] 新学術領域「ユビキチンネオバイオロジー:拡大するタンパク質制御システム」

    • URL

      http://ubiquitin.jp/

    • Related Report
      2012 Annual Research Report
  • [Funded Workshop] Diverse functions of Ubiquitin : Degradation, Signaling, and Beyond2016

    • Place of Presentation
      京都大学
    • Related Report
      2016 Annual Research Report

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Published: 2012-11-27   Modified: 2018-03-28  

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