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Cilium-centrosome system regulating biosignal flows

Organizer

Project AreaCilium-centrosome system regulating biosignal flows
Project/Area Number 24113001
Research Category

Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

Allocation TypeSingle-year Grants
Review Section Biological Sciences
Research InstitutionInstitute of Physical and Chemical Research (2016)
Osaka University (2012-2015)

Principal Investigator

Hamada Hiroshi  国立研究開発法人理化学研究所, 多細胞システム形成研究センター, チームリーダー (00208589)

Co-Investigator(Kenkyū-buntansha) 月田 早智子  大阪大学, 生命機能研究科, 教授 (00188517)
松崎 文雄  国立研究開発法人理化学研究所, 多細胞システム形成研究センター, チームリーダー (10173824)
稲垣 昌樹  愛知県がんセンター(研究所), 腫瘍医化学部, 部長 (30183007)
五島 直樹  国立研究開発法人産業技術総合研究所, 創薬分子プロファイリング研究センター, 研究チーム部長 (70215482)
広野 雅文  法政大学, 生命科学部, 教授 (10212177)
岸本 健雄  お茶の水女子大学, サイエンスエデュケーションセンター, 客員教授 (00124222)
Co-Investigator(Renkei-kenkyūsha) KITAGAWA Daiju  国立遺伝学研究所, 分子遺伝研究系, 教授 (80605725)
HIROTSUNE Shinji  大阪市立大学, 医学研究科, 教授 (80337526)
Research Collaborator KIKKAWA Masahide  
SUGIMOTO Asako  
TOYOSHIMA Fumiko  
Project Period (FY) 2012-06-28 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥105,430,000 (Direct Cost: ¥81,100,000、Indirect Cost: ¥24,330,000)
Fiscal Year 2016: ¥22,490,000 (Direct Cost: ¥17,300,000、Indirect Cost: ¥5,190,000)
Fiscal Year 2015: ¥18,720,000 (Direct Cost: ¥14,400,000、Indirect Cost: ¥4,320,000)
Fiscal Year 2014: ¥22,620,000 (Direct Cost: ¥17,400,000、Indirect Cost: ¥5,220,000)
Fiscal Year 2013: ¥18,720,000 (Direct Cost: ¥14,400,000、Indirect Cost: ¥4,320,000)
Fiscal Year 2012: ¥22,880,000 (Direct Cost: ¥17,600,000、Indirect Cost: ¥5,280,000)
Keywords繊毛 / 中心体 / シグナル因子 / 細胞・組織 / 発生制御 / 発生・分化 / 発現制御
Outline of Final Research Achievements

We have performed following activities.
1) International symposium (Cilia and Centrosome: Current Advances and Future Directions) was held in RIKEN CDB (Kobe) on Nov. 27~Nov. 29. About 120 scientists including 6 invited speakers from oversea participated in this symposium, and we actively exchanged updated information on cilia and centrosome. 2) We had a symposium on cilia in the 39th Annual Meeting of Japanese Society of Molecular Biology, where we introduced the physiological role of cilia and on human genetic disorders due to ciliary dysfunction.

Report

(6 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Annual Research Report
  • 2014 Annual Research Report
  • 2013 Annual Research Report
  • 2012 Annual Research Report

Research Products

(74 results)

All 2017 2016 2015 2014 2013 2012 Other

All Int'l Joint Research (10 results) Journal Article (37 results) (of which Int'l Joint Research: 4 results,  Peer Reviewed: 36 results,  Open Access: 9 results,  Acknowledgement Compliant: 23 results) Presentation (18 results) (of which Int'l Joint Research: 6 results,  Invited: 18 results) Remarks (8 results) Funded Workshop (1 results)

  • [Int'l Joint Research] University of Munster(ドイツ)

    • Related Report
      2016 Annual Research Report
  • [Int'l Joint Research] Institute of Molecular and Cell Biology(シンガポール)

    • Related Report
      2016 Annual Research Report
  • [Int'l Joint Research] Yale University/John's Hopkins University(米国)

    • Related Report
      2016 Annual Research Report
  • [Int'l Joint Research] MRC/University of Edinburgh(英国)

    • Related Report
      2016 Annual Research Report
  • [Int'l Joint Research] Oxford University/University of Birmingham/Cambridge University(英国)

    • Related Report
      2015 Annual Research Report
  • [Int'l Joint Research] University Medical Center Hamburg/University of Munster/Hohenheim University(ドイツ)

    • Related Report
      2015 Annual Research Report
  • [Int'l Joint Research] New York University/Emory University(米国)

    • Related Report
      2015 Annual Research Report
  • [Int'l Joint Research] Tel Aviv University(イスラエル)

    • Related Report
      2015 Annual Research Report
  • [Int'l Joint Research] 北京工科大学(中国)

    • Related Report
      2015 Annual Research Report
  • [Int'l Joint Research]

    • Related Report
      2015 Annual Research Report
  • [Journal Article] A Wnt5 Activity Asymmetry and Intercellular Signaling via PCP Proteins Polarize Node Cells for Left-Right Symmetry Breaking.2017

    • Author(s)
      Minegishi, K., Hashimoto, M., Ajima, R., Takaoka, K., Shinohara, K., Ikawa, Y., Nishimura, H., McMahon, AP., Willert, K., Okada, Y., Sasaki, H., Shi, D., Fujimori, T., Ohtsuka, T., Igarashi, Y., Yamaguchi, TP., Shimono, A., Shiratori, H., Hamada, H.
    • Journal Title

      Developmental Cell

      Volume: 40 Pages: 439-452

    • DOI

      10.1016/j.devcel.2017.02.010

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Transport of outer dynein proteins to ciliary axoneme requires a cytoplasmic protein Lrrc6.2016

    • Author(s)
      Inaba Y., Shinohara, K., Botilde, Y., Nabeshima, R., Takaoka, K., Ajima, R., Lamri, L., Takeda, H., Saga, Y., Nakamura, T. and Hamada, H.
    • Journal Title

      Genes to Cells

      Volume: 21 Pages: 728-739

    • DOI

      10.1111/gtc.12380

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Multiciliated cell basal bodies align in stereotypical patterns coordinated by the apical cytoskeleton.2016

    • Author(s)
      Herawati E, Taniguchi D, Kanoh H, Tateishi K, Ishihara S, Tsukita S.
    • Journal Title

      The Journal of Cell Biology

      Volume: 214 Pages: 571-586

    • DOI

      10.1083/jcb.201601023

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Cell-cycle-independent transitions in temporal identity of mammalian neural progenitor cells2016

    • Author(s)
      Okamoto M, Miyata T, Konno D, Ueda HR, Kasukawa T, Hashimoto M, Matsuzaki F, Kawaguchi A
    • Journal Title

      Nature Commun.

      Volume: 7 Pages: 11349-11349

    • DOI

      10.1038/ncomms11349

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] SAS-6 engineering reveals interdependence between cartwheel and microtubules in determining centriole architecture2016

    • Author(s)
      Hilbert M*, Noga A*, Frey D*, Hamel V*, Guichard P, Kraatz SH, Pfreundschuh M, Hosner S, Flückiger I, Jaussi R, Wieser MM, Thieltges KM, Deupi X, Müller DJ, Kammerer RA, Gönczy P**, Hirono M**, Steinmetz MO**(**Corresponding authors)
    • Journal Title

      Nat Cell Biol.

      Volume: 18 Pages: 393-403

    • DOI

      10.1038/ncb3329

    • Related Report
      2016 Annual Research Report 2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Cell cycle-independent transitions in temporal identity of mammalian neural progenitor cells2016

    • Author(s)
      Okamoto M, Miyata T, Konno D, Ueda HR, Kasukawa T, Hashimoto M, Matsuzaki F*, and Kawaguchi A* (corresponding authors)
    • Journal Title

      Nat Commun.

      Volume: 印刷中

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Tanaka H, Yamamoto Y, Kashihara H, Yamazaki Y, Tani K, Fujiyoshi Y, Mineta K, Takeuchi K, Tamura A, Tsukita S.2016

    • Author(s)
      Claudin-21 Has a Paracellular Channel Role at Tight Junctions.
    • Journal Title

      Mol. Cell Biol.

      Volume: 4;36(6) Pages: 1-10

    • DOI

      10.1128/mcb.00758-15

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Ndel1 suppresses ciliogenesis in proliferating cells by regulating the trichoplein-Aurora A pathway.2016

    • Author(s)
      Inaba H, Goto H, Kasahara K, Kumamoto K, Yonemura S, Inoko A, Yamano S, Wanibuchi H, He D, Goshima N, Kiyono T, Hirotsune S, Inagaki M.
    • Journal Title

      The Journal of Cell Biology

      Volume: 212 Pages: 409-23

    • DOI

      10.1083/jcb.201507046

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Absence of radial spokes in mouse node cilia is required for rotational movement but confers ultrastructural instability as a trade-off.2015

    • Author(s)
      Shinohara, K., Chen, D., Nishida, T., Misaki, K., Yonemura, S. and Hamada, H.
    • Journal Title

      Dev Cell

      Volume: 35 Pages: 236-246

    • DOI

      10.1016/j.devcel.2015.10.001

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] RBM14 prevents assembly of centriolar protein complexes and maintains mitotic spindle integrity.2015

    • Author(s)
      Shiratsuchi, G., Takaoka, K., Ashikawa, T., Hamada H. and Kitagawa, D
    • Journal Title

      EMBO J.

      Volume: 34 Pages: 97-114

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Intestinal deletion of Claudin-7 enhances paracellular organic solute flux and initiates colonic inflammation in mice2015

    • Author(s)
      Tanaka H, Takechi M, Kiyonari H, Shioi G, Tamura A, Tsukita S.
    • Journal Title

      Gut

      Volume: 印刷中 Pages: 1529-38

    • DOI

      10.1136/gutjnl-2014-308419

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Structural insight into tight junction disassembly by Clostridium perfringens enterotoxin.2015

    • Author(s)
      Y. Saitoh, H. Suzuki, K. Tani, K. Nishikawa, K. Irie, Y. Ogura, A. Tamura, S. Tsukita, and Y. Fujiyoshi
    • Journal Title

      Science

      Volume: 347 Pages: 775-778

    • DOI

      10.1126/science.1261833

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Self-regulated left-right asymmetric expression of Pitx2c in the developing limb2014

    • Author(s)
      Shiratori, H., Yashiro, Iwai, N., Oki, S., Ikawa, Y., Kanata, K., and Hamada, H.
    • Journal Title

      Developmental Biology

      Volume: 395 Pages: 331-341

    • DOI

      10.1016/j.ydbio.2014.09.002

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Direct interaction of Plk4 with STIL ensures formation of a single procentriole per parental centriole, Nature Communications2014

    • Author(s)
      Midori Ohta, Tomoko Ashikawa, Yuka Nozaki, Hiroko Kozuka-Hata, Hidemasa Goto, Masaki Inagaki, Masaaki Oyama and Daiju Kitagawa
    • Journal Title

      Nature Communications

      Volume: 5:5267 Pages: 1-12

    • DOI

      10.1038/ncomms6267

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Ubiquitin-proteasome system controls ciliogenesis at the initial step of axoneme extension2014

    • Author(s)
      Kasahara K, Kawakami Y, Kiyono T, Yonemura S, Kawamura Y, Era S, Matsuzaki F, Goshima N, Inagaki M.
    • Journal Title

      Nature Communications

      Volume: 5 Pages: 5081-5081

    • DOI

      10.1038/ncomms6081

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Cdk1 Coordinates Timely Activation of MKlp2 Kinesin with Relocation of the Chromosome Passenger Complex for Cytokinesis.2014

    • Author(s)
      Kitagawa, M.
    • Journal Title

      Cell Rep.

      Volume: 7 Pages: 166-179

    • DOI

      10.1016/j.celrep.2014.02.034

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Pih1d3 is required for cytoplasmic preassembly of axonemal dynein in mouse sperm.2014

    • Author(s)
      Dong, F., Shinohara, K., Nabeshima, R., Botilde, Y., Asai, Y., Fukumoto, A., Hasegawa, T., Matsuo, M., Takeda, H., Shiratori, H., Nakamura T., and Hamada, H.
    • Journal Title

      Journal of Cell Biology

      Volume: 204 Pages: 203-213

    • DOI

      10.1083/jcb.201304076

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Hydrodynamic phase synchronization in mouse node cilia2013

    • Author(s)
      Takamatsu, A.*, Shinohara, K., Ishikawa, T. and Hamada, H.
    • Journal Title

      Physical Review Letters.

      Volume: 110 Pages: 248107-248107

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Cluap1 localizes preferentially to the base and tip of cilia and is required for ciliogenesis in the mouse embryo2013

    • Author(s)
      Botilde, Y., Yoshiba, S., Shinohara, K., Hasegawa, T., Nishimura, H., Shiratori, H. and Hamada, H.
    • Journal Title

      Dev. Biol.

      Volume: 381 Pages: 203-212

    • DOI

      10.1016/j.ydbio.2013.05.024

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Asymmetric rotational stroke in mouse node cilia during left-right determination.2013

    • Author(s)
      Takamatsu, A., Ishikawa, T., Shinohara, K., and Hamada, H.
    • Journal Title

      Physical Review E.

      Volume: 87 Pages: 050701-050701

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] The association of microtubules with tight junctions is promoted by cingulin phosphorylation by AMPK.2013

    • Author(s)
      Yano T, Matsui T, Tamura A, Uji M, Tsukita S.
    • Journal Title

      J Cell Biol

      Volume: 25 Pages: 605-614

    • DOI

      10.1083/jcb.201304194

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Two appendages homologous between basal bodies and centrioles are formed using distinct Odf2 domains2013

    • Author(s)
      Tateishi K, Yamazaki Y, Nishida T, Watanabe S, Kunimoto K, Ishikawa H, Tsukita S.
    • Journal Title

      J Cell Biol.

      Volume: 203 Pages: 417-425

    • DOI

      10.1083/jcb.201303071

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] PI 3-kinase-dependent phosphorylation of Plk1-Ser99 promotes association with 14-3-3γ and is required for metaphase-anaphase transition2013

    • Author(s)
      Kasahara, K., Goto, H., Izawa, I., Kiyono, T., Watanabe, N., Elowe, S., Nigg, E.A. and Inagaki, M.
    • Journal Title

      Nature Communications

      Volume: 4 Pages: 1882-1882

    • DOI

      10.1038/ncomms2879

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Loss of claudins 2 and 15 from mice causes defects in paracellular Na+ flow and nutrient transport in lumen and leads to death from malnutrition2013

    • Author(s)
      Wada M, Tamura A, Takahashi N, Tsukita S
    • Journal Title

      Gastroenterology.

      Volume: 144 Pages: 369-380

    • DOI

      10.1053/j.gastro.2012.10.035

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] PI 3-kinase-dependent phosphorylation of Plk1-Ser99 promotes its association with 14-3-3γ and is required for metaphase-anaphase transition.2013

    • Author(s)
      Kasahara, K.
    • Journal Title

      Nat. Commun.

      Volume: ---

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cell division modes and cleavage planes of neural progenitors during mammalian cortical development.2013

    • Author(s)
      Matsuzaki, F.
    • Journal Title

      Cold Spring Harb Perspect Biol. Mammalian Develop.

      Volume: ---

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Activation of Aurora-A is Essential for Neuronal Migration via Modulation of Microtubule Organization.2013

    • Author(s)
      Takitoh, T.
    • Journal Title

      J. Neuroscience

      Volume: ---

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Fluid flow and interlinked feedback loops establish left-right asymmetric decay of Cerl2 mRNA in the mouse embryo2012

    • Author(s)
      Nakamura, T., Saito, D., Kawasumi, A., Shinohara, K., Asai, Y., Takaoka, K., Dong, F., Takamatsu, A., Belo, J.A., Mochizuki, A., and Hamada, H.
    • Journal Title

      Nat. Commun.

      Volume: 3 Pages: 1322-1322

    • DOI

      10.1038/ncomms2319

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] EpCAM contributes to formation of functional tight junction in the intestinal epithelium by recruiting claudin proteins.2012

    • Author(s)
      Lei Z., et al
    • Journal Title

      Dev. Biol.

      Volume: 15 Pages: 136-145

    • DOI

      10.1016/j.ydbio.2012.07.005

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cilia at the Node of Mouse Embryos Sense Fluid Flow for Left-Right Determination via Pkd22012

    • Author(s)
      Yoshiba S, Shiratori H, Kuo IY, Kawasumi A, Shinohara K, Nonaka S, Asai Y, Sasaki G, Belo JA, Sasaki H, Nakai J, Dworniczak B, Ehrlich BE, Pennekamp P, Hamada H
    • Journal Title

      Science

      Volume: 338(6104):226-3 Pages: 226-231

    • DOI

      10.1126/science.1222538

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Lefty-right asymmetry: conserved or diverged2012

    • Author(s)
      Nakamura, T.
    • Journal Title

      Development

      Volume: 139 Pages: 3257-3262

    • DOI

      10.1242/dev.061606

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] In search of Turing in vivo : understanding Nodal and Lefty behavior.2012

    • Author(s)
      Hamada, H.
    • Journal Title

      Dev. Cell

      Volume: 22 Pages: 911-912

    • DOI

      10.1016/j.devcel.2012.05.003

    • Related Report
      2012 Annual Research Report
  • [Journal Article] Claudin-based paracellular proton barrier in the stomach.2012

    • Author(s)
      Tamura A., et al
    • Journal Title

      Annals of The New York Academy of Sciences

      Volume: 1,258 Pages: 108-114

    • DOI

      10.1111/j.1749-6632.2012.06570.x

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Trichoplein and Aurora A block aberrant primary cilia assembly in proliferating cells.2012

    • Author(s)
      Inoko, A., …., Inagaki, M.
    • Journal Title

      J Cell Biol.

      Volume: 197 Pages: 391-405

    • DOI

      10.1083/jcb.201106101

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The mammalian DM domain transcription factor Dmrta2 is required for early embryonic development of the cerebral cortex.2012

    • Author(s)
      Konno, D.
    • Journal Title

      PLoS One

      Volume: 7

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prox1 postmitotically defines dentate gyrus cells by specifying the granule cell identity over the CA3 pyramidal cell fate in the hippocampus.2012

    • Author(s)
      Iwano, T.
    • Journal Title

      Development

      Volume: 139 Pages: 3051-3062

    • DOI

      10.1242/dev.080002

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Control of asymmetric cell division of mammalian neural progenitors2012

    • Author(s)
      Atsunori Shitamukai, Fumio Matsuzaki
    • Journal Title

      Dev Growth Differ.

      Volume: 54 Pages: 277-286

    • DOI

      10.1111/j.1440-169x.2012.01345.x

    • NAID

      10031136901

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Presentation] Immotile cilia in left-right symmetry breaking in the mouse embryo2017

    • Author(s)
      Hiroshi Hamada
    • Organizer
      Gordon Research Conference (CILIA, MUCUS & MUCOCILIARY INTERACTIONS)
    • Place of Presentation
      Galveston, TX, USA
    • Year and Date
      2017-02-12
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Role of cilia in left-right asymmetry2016

    • Author(s)
      Hiroshi Hamada
    • Organizer
      CDB-KAIST-IGDB Joint Symposium
    • Place of Presentation
      Daejun, South Korea
    • Year and Date
      2016-10-26
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Role of cilia in left-right symmetry breaking2016

    • Author(s)
      Hiroshi Hamada
    • Organizer
      Cilia 2016
    • Place of Presentation
      The Royal Tropical Institute, Amsterdam
    • Year and Date
      2016-10-04
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Role of cilia and fluid flow in left-right symmetry breaking2016

    • Author(s)
      Hiroshi Hamada
    • Organizer
      The 2016 Santa Cruz Developmental Biology Meeting
    • Place of Presentation
      UC-Santa Cruz, Santa Cruz, USA
    • Year and Date
      2016-08-13
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Cortical expansion during the development of mammalian complex brains2015

    • Author(s)
      Matsuzaki, F.
    • Organizer
      第38回分子生物学会年会
    • Place of Presentation
      神戸国際会議場(兵庫県神戸市)
    • Year and Date
      2015-12-01
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Role of maternal Nodal signaling in pre-mplantation development2015

    • Author(s)
      Hamada H.
    • Organizer
      Mouse Molecular Genetics
    • Place of Presentation
      Hinxton, UK
    • Year and Date
      2015-09-16
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Role of tight junctions in biological systems2015

    • Author(s)
      Tsukita,S.
    • Organizer
      Singapore Gastric Cancer Consortium 8th Annual Scientific Meeting
    • Place of Presentation
      Tower Block, Singapore
    • Year and Date
      2015-07-22
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Role of motile and immotile cilia in left-right asymmetry2015

    • Author(s)
      Hamada, H.
    • Organizer
      Keystone Symposia (Heart Disease and Regeneration: Insights from Development)
    • Place of Presentation
      Copper Mountain, Colorado, USA
    • Year and Date
      2015-03-01 – 2015-03-06
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Role of motile and immotile cilia in left-right symmetry breaking2015

    • Author(s)
      Hamada, H.
    • Organizer
      Gordon Research Conference (CILIA, MUCUS & MUCOCILIARY INTERACTIONS)
    • Place of Presentation
      Galveston, Texas, USA
    • Year and Date
      2015-02-08 – 2015-02-12
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Polarization of node cells by asymmetric Wnt5 distribution2013

    • Author(s)
      Hamada, H.
    • Organizer
      OIST Conference (Gradients and Signaling)
    • Place of Presentation
      Okinawa, Japan
    • Year and Date
      2013-11-11 – 2013-11-15
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Generating and sensing the flow signal for establishing left-right asymmetry2013

    • Author(s)
      Hamada, H.
    • Organizer
      Annual Meeting of Korean Physiology Society
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      2013-10-23 – 2013-10-25
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Multiple roles of cilia in left-right symmetry breaking2013

    • Author(s)
      Hamada, H.
    • Organizer
      The 7th TAKAO Symposium
    • Place of Presentation
      Tokyo, Japan
    • Year and Date
      2013-07-13 – 2013-07-15
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Generating and sensing fluid flow by cilia2013

    • Author(s)
      Hamada, H.
    • Organizer
      Joint International Meeting of the German Society for Cell Biology (DGZ) and the German Society for Developmental Biology (GfE)
    • Place of Presentation
      Heidelberg,Germany
    • Year and Date
      2013-03-20
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Establishing left-right asymmetry2013

    • Author(s)
      Hamada, H.
    • Organizer
      InStem Mouse Embryology Workshop
    • Place of Presentation
      Bangalore, India
    • Year and Date
      2013-03-11
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] The origin of anterior-posterior polarity and first cell specification in the mouse embryo2013

    • Author(s)
      Hamada, H.
    • Organizer
      The 11th Annual CDB Symposium: The making of a vertebrate
    • Place of Presentation
      CDB, Kobe
    • Year and Date
      2013-03-04
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Generating and sensing fluid flow by cilia2012

    • Author(s)
      Hamada, H.
    • Organizer
      Hong Kong Society for Developmental Biology Symposium :From Embryology to Disease Mechanisms.
    • Place of Presentation
      Hong Kong,China
    • Year and Date
      2012-11-26
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Role of cilia in generating and sensing fluid flow2012

    • Author(s)
      Hamada, H.
    • Organizer
      RIKEN Quantitative Biology Center Inaugural Symposium.
    • Place of Presentation
      Kobe International Conference Center
    • Year and Date
      2012-11-05
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Origin of the distal visceral endoderm origin of the first cell specification in the mouse embryo2012

    • Author(s)
      Hamada, H.
    • Organizer
      EMBO Workshop on Cell Biology of Early Mouse Development
    • Place of Presentation
      Oxford University, Cambridge,United Kingdom
    • Year and Date
      2012-09-09
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Remarks] 新学術領域研究『シリア・中心体系による生体情報フローの制御』

    • URL

      https://www.nig.ac.jp/labs/NigPrjct/cilia-centrosome/index.html

    • Related Report
      2016 Annual Research Report
  • [Remarks] 個体パターニング研究チーム

    • URL

      http://www.cdb.riken.jp/research/laboratory/hamada.html

    • Related Report
      2015 Annual Research Report
  • [Remarks] 月田研究室

    • URL

      http://www.fbs.osaka-u.ac.jp/labs/tsukita/

    • Related Report
      2015 Annual Research Report
  • [Remarks] Cold Spring Harbor Perspectives in Biology

    • URL

      http://cshperspectives.cshlp.org/search?fulltext=fumio+Matsuzaki&submit=yes&x=10&y=11

    • Related Report
      2015 Annual Research Report
  • [Remarks] 非対称細胞分裂研究チーム

    • URL

      http://www.cdb.riken.jp/cas/

    • Related Report
      2015 Annual Research Report
  • [Remarks] 新学術領域研究、シリア・中心体系による生体情報フローの制御

    • URL

      http://www.nig.ac.jp/labs/NigPrjct/cilia-centrosome/index.html

    • Related Report
      2014 Annual Research Report
  • [Remarks] 新学術領域研究、シリア・中心体による生体情報フローの制御

    • URL

      http://www.nig.ac.jp/labs/NigPrjct/cilia-centrosome/index.html

    • Related Report
      2013 Annual Research Report
  • [Remarks] 文部科学省科学研究費補助金「新学術領域研究」 シリア・中心体系による生体情報フローの制御

    • URL

      http://www.nig.ac.jp/labs/NigPrjct/cilia-centrosome/index.html

    • Related Report
      2012 Annual Research Report
  • [Funded Workshop] The 28th CDB Meeting "Cilia an Centrosomes: Current Advances and Future Directions"2016

    • Place of Presentation
      兵庫県神戸市、理研・多細胞システム形成研究センター
    • Year and Date
      2016-11-27
    • Related Report
      2016 Annual Research Report

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Published: 2012-11-27   Modified: 2022-02-07  

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