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Molecular basis of host cell competency in virus infection

Administrative Group

Project AreaMolecular basis of host cell competency in virus infection
Project/Area Number 24115001
Research Category

Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

Allocation TypeSingle-year Grants
Review Section Biological Sciences
Research InstitutionUniversity of Tsukuba

Principal Investigator

NAGATA Kyosuke  筑波大学, 学長 (40180492)

Co-Investigator(Kenkyū-buntansha) 脇田 隆字  国立感染症研究所, ウイルス第二部, 副所長 (40280789)
藤田 尚志  京都大学, ウイルス研究所, 教授 (10156870)
柳 雄介  九州大学, 医学(系)研究科(研究院), 教授 (40182365)
小池 智  公益財団法人東京都医学総合研究所, ゲノム医科学研究分野, プロジェクトリーダー (30195630)
夏目 徹  国立研究開発法人産業技術総合研究所, 創薬分子プロファイリング研究センター, センター長 (00357683)
佐々木 顕  総合研究大学院大学, 先導科学研究科, 教授 (90211937)
Co-Investigator(Renkei-kenkyūsha) Park Sam-Yong  横浜市立大学, 生命医科学研究科, 教授 (20291932)
Takeyasu Kunio  京都大学, 生命科学研究科, 名誉教授 (40135695)
Takaori Akifumi  京都大学, 医学系研究科, 教授 (20324626)
Arase Hisashi  大阪大学, 微生物病研究所, 教授 (10261900)
Iba Hideo  千葉大学, 真菌医学研究センター, 教授 (60111449)
Koyanagi Yoshio  京都大学, ウイルス再生医科学研究所, 教授 (80215417)
Project Period (FY) 2012-06-28 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥53,950,000 (Direct Cost: ¥41,500,000、Indirect Cost: ¥12,450,000)
Fiscal Year 2016: ¥15,600,000 (Direct Cost: ¥12,000,000、Indirect Cost: ¥3,600,000)
Fiscal Year 2015: ¥10,400,000 (Direct Cost: ¥8,000,000、Indirect Cost: ¥2,400,000)
Fiscal Year 2014: ¥12,220,000 (Direct Cost: ¥9,400,000、Indirect Cost: ¥2,820,000)
Fiscal Year 2013: ¥10,400,000 (Direct Cost: ¥8,000,000、Indirect Cost: ¥2,400,000)
Fiscal Year 2012: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Keywordsウイルス / 宿主因子 / コンピテンシー / 自然免疫 / 構造解析 / 数理科学解析 / オミックス解析 / 感染コンピテンシー / 病原性発現 / 宿主特異性 / 許容性 / 共同研究インターンシップ / 感染防御 / 感染症 / 数理科学 / プロテオミクス / ポストゲノム
Outline of Final Research Achievements

In this research, we aimed to promote the research among groups and to support the new research concepts. Along with the collaborative research, we will understand the molecular basis of host-specific viral replication resulting in pathogenecity and antagonism between host defense system and infectious agents. Based on these findings, we aimed to establish general concepts, which determine tolerance / non-tolerance against infectious agents, .

Report

(6 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Annual Research Report
  • 2014 Annual Research Report
  • 2013 Annual Research Report
  • 2012 Annual Research Report
  • Research Products

    (83 results)

All 2017 2016 2015 2014 2013 2012 Other

All Journal Article (45 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 45 results,  Open Access: 14 results,  Acknowledgement Compliant: 7 results) Presentation (33 results) (of which Int'l Joint Research: 13 results,  Invited: 12 results) Remarks (3 results) Funded Workshop (2 results)

  • [Journal Article] Mitotic phosphorylation of CCCTC-binding factor (CTCF) reduces its DNA binding activity.2017

    • Author(s)
      Sekiya T, Murano K, Kato K, Kawaguchi A, Nagata K.
    • Journal Title

      FEBS Open Bio

      Volume: 7 Issue: 3 Pages: 397-404

    • DOI

      10.1002/2211-5463.12189

    • NAID

      120007129136

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Pre-mRNA Processing Factor Prp18 Is a Stimulatory Factor of Influenza Virus RNA Synthesis and Possesses Nucleoprotein Chaperone Activity.2017

    • Author(s)
      Minakuchi M, Sugiyama K, Kato Y, Naito T, Okuwaki M, Kawaguchi A, Nagata K.
    • Journal Title

      Journal of Virology

      Volume: 91 Issue: 3

    • DOI

      10.1128/jvi.01398-16

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Generation of a Genetically Stable High-Fidelity Influenza Vaccine Strain.2017

    • Author(s)
      Naito T, Mori K, Ushirogawa H, Takizawa N, Nobusawa E, Odagiri T, Tashiro M, Ohniwa RL, Nagata K, Saito M.
    • Journal Title

      Journal of Virology

      Volume: 91

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Polycomb repressive complex 2 facilitates the nuclear export of the influenza viral genome through the interaction with M1.2016

    • Author(s)
      Asaka MN, Kawaguchi A, Sakai Y, Mori K, Nagata K.
    • Journal Title

      Scientific Reports

      Volume: 6 Issue: 1 Pages: 33608-33608

    • DOI

      10.1038/srep33608

    • NAID

      120007129419

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Functional characterization and efficient detection of Nucleophosmin/NPM1 oligomers.2016

    • Author(s)
      Lin J, Hisaoka M, Nagata K, Okuwaki M.
    • Journal Title

      Biochemical Biophysical Research Communications

      Volume: 480 Pages: 702-708

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Efficient DNA binding of NF-κB requires the chaperone-like function of NPM1.2016

    • Author(s)
      Lin J, Kato M, Nagata K, Okuwaki M.
    • Journal Title

      Nucleic Acids Research

      Volume: gkw1285 Pages: 3707-3723

    • DOI

      10.1093/nar/gkw1285

    • NAID

      120007129193

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Influenza virus induces cholesterol-enriched endocytic recycling compartments for budozone formation via cell cycle-independent centrosome maturation2015

    • Author(s)
      Kawaguchi A, Hirohama M, Harada Y, Osari S, Nagata K.
    • Journal Title

      PLoS pathogens

      Volume: 11 Issue: 11 Pages: e1005284-e1005284

    • DOI

      10.1371/journal.ppat.1005284

    • NAID

      120007129744

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] pp32 and APRIL are host cell-derived regulators of influenza virus RNA synthesis from cRNA2015

    • Author(s)
      Sugiyama K, Kawaguchi A, Okuwaki M, Nagata K.
    • Journal Title

      eLife

      Volume: 4

    • DOI

      10.7554/elife.08939

    • NAID

      120007135522

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Actin-Modulating Protein Cofilin Is Involved in the Formation of Measles Virus Ribonucleoprotein Complex at the Perinuclear Region2015

    • Author(s)
      Koga R, Sugita Y, Noda T, Yanagi Y, Ohno S.
    • Journal Title

      Journal of Virology

      Volume: 89 Issue: 20 Pages: 10524-10531

    • DOI

      10.1128/jvi.01819-15

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] A Novel Tricyclic Polyketide, Vanitaracin A, Specifically Inhibits the Entry of Hepatitis B and D Viruses by Targeting Sodium Taurocholate Cotransporting Polypeptide2015

    • Author(s)
      Kaneko M, Watashi K, Kamisuki S, Matsunaga H, Iwamoto M, Kawai F, Ohashi H, Tsukuda S, Shimura S, Suzuki R, Aizaki H, Sugiyama M, Park SY, Ito T, Ohtani N, Sugawara F, Tanaka Y, Mizokami M, Sureau C, Wakita T
    • Journal Title

      J Virol

      Volume: 89 Issue: 23 Pages: 11945-11953

    • DOI

      10.1128/jvi.01855-15

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Nedd4-induced mono-ubiquitination of IRS-2 enhances IGF signaling and mitogenic activity.2015

    • Author(s)
      Toshiaki Fukushima, Hidehito Yoshihara, Haruka Furuta, Fumihiko Hakuno, Jing Luan, Cunming Duan, Yasushi Saeki, Keiji Tanaka, Shun-Ichiro Iemura, TohruNatsume, Kazuhiro Chida, Yusuke Nakatsu, Hideaki Kamata, Tomoichiro Asano, and Shin-Ichiro Takahashi
    • Journal Title

      Nature communications

      Volume: 6 Issue: 1 Pages: 6780-6780

    • DOI

      10.1038/ncomms7780

    • NAID

      120006348510

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Oseltamivir Expands Quasispecies of Influenza Virus through Cell-to-cell Transmission2015

    • Author(s)
      Mori K, Murano K, Ohniwa RL, Kawaguchi A, Nagata K.
    • Journal Title

      Scientific Reports

      Volume: 5 Issue: 1 Pages: 9163-9163

    • DOI

      10.1038/srep09163

    • NAID

      120007130320

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Actin-myosin network is required for proper assembly of influenza virus particles2015

    • Author(s)
      Kumakura M, Kawaguchi A, Nagata K.
    • Journal Title

      Virology

      Volume: 476 Pages: 141-150

    • DOI

      10.1016/j.virol.2014.12.016

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Artificial human Met agonists based on macrocycle scaffolds2015

    • Author(s)
      Ito K, Sakai K, Suzuki Y, Ozawa N, Hatta T, Natsume T, Matsumoto K, Suga H.
    • Journal Title

      Nature Communications

      Volume: 6 Issue: 1 Pages: 6373-6373

    • DOI

      10.1038/ncomms7373

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Cyclosporin A and its analogs inhibit hepatitis B virus entry into cultured hepatocytes through targeting a membrane transporter, sodium taurocholate cotransporting polypeptide (NTCP)2014

    • Author(s)
      Watashi K, Sluder A, Daito T, Matsunaga S, Ryo A, Nagamori S, Iwamoto M, Nakajima S, Tsukuda S, Borroto-Esoda K, Sugiyama M, Tanaka Y, Kanai Y, Kusuhara H, Mizokami M, Wakita T
    • Journal Title

      Hepatology

      Volume: 59 Issue: 5 Pages: 1726-1737

    • DOI

      10.1002/hep.26982

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A novel function of human Pumilio proteins in cytoplasmic sensing of viral infection.2014

    • Author(s)
      Narita R, Takahasi K, Murakami E, Hirano E, Yamamoto SP, Yoneyama M, Kato H, Fujita T.
    • Journal Title

      PLoS Pathog.

      Volume: 10 Issue: 10 Pages: 1-11

    • DOI

      10.1371/journal.ppat.1004417

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] ZFP36L1 and ZFP36L2 control LDLR mRNA stability via the ERK-RSK pathway2014

    • Author(s)
      Adachi S, Homoto M, Tanaka R, Hioki Y, Murakami H, Suga H, Matsumoto M, Nakayama KI, Hatta T, Iemura S, Natsume T.
    • Journal Title

      Nucleic Acids Research

      Volume: 42 Issue: 15 Pages: 10037-10049

    • DOI

      10.1093/nar/gku652

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Long Noncoding RNA NEAT1-Dependent SFPQ Relocation from Promoter Region to Paraspeckle Mediates IL8 Expression upon Immune Stimuli2014

    • Author(s)
      Imamura K, Imamachi N, Akizuki G, Kumakura M, Kawaguchi A, Nagata K, Kato A, Kawaguchi Y, Sato H, Yoneda M, Kai C, Yada T, Suzuki Y, Yamada T, Ozawa T, Kaneki K, Inoue T, Kobayashi M, Kodama T, Wada Y, Sekimizu K and Akimitsu N.
    • Journal Title

      Molecular cell

      Volume: 53 Issue: 3 Pages: 393

    • DOI

      10.1016/j.molcel.2014.01.009

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Involvement of the N-terminal portion of influenza virus RNA polymerase subunit PB1 in nucleotide recognition.2014

    • Author(s)
      Binh NT, Wakai C, Kawaguchi A, Nagata K.
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 443 Issue: 3 Pages: 975-979

    • DOI

      10.1016/j.bbrc.2013.12.071

    • NAID

      120007130532

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] DHX36 Enhances RIG-I Signaling by Facilitating PKR-Mediated Antiviral Stress Granule Formation2014

    • Author(s)
      Yoo, J-S., Takahasi, K., Ng, CS., Ouda, R., Onomoto, K., Yoneyama, M., Lai, J-C., Lattmann, S., Nagamine, Y., Matsui, T., Iwabuchi, K., Kato, H. Fujita, T.
    • Journal Title

      PLoS Pathog

      Volume: 10(3) Issue: 3 Pages: 1-18

    • DOI

      10.1371/journal.ppat.1004012

    • NAID

      120005466661

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The N-terminal region of influenza virus polymerase PB1 adjacent to the PA binding site is involved in replication but not transcription of the viral genome.2013

    • Author(s)
      Binh NT, Wakai C, Kawaguchi A, Nagata K.
    • Journal Title

      Frontiers in Microbiology

      Volume: 4 Pages: 398-398

    • NAID

      120007130538

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] DNA replication-dependent binding of CTCF plays a critical role in adenovirus genome functions.2013

    • Author(s)
      Komatsu T, Sekiya T, Nagata K.
    • Journal Title

      Scientific Report

      Volume: 3 Issue: 1 Pages: 2187-2187

    • DOI

      10.1038/srep02187

    • NAID

      120007136881

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Signal peptidase complex subunit 1 participates in the assembly of hepatitis C virus through an interaction with E2 and NS22013

    • Author(s)
      Suzuki R, Matsuda M, Watashi K, Aizaki H, Matsuura Y, Wakita T, Suzuki T
    • Journal Title

      PLoS Pathog

      Volume: 9 Issue: 8 Pages: 1-12

    • DOI

      10.1371/journal.ppat.1003589

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Specific inhibition of hepatitis C virus entry into host hepatocytes by fungi-derived sulochrin and its derivatives2013

    • Author(s)
      Nakajima S, Watashi K, Kamisuki S, Tsukuda S, Takemoto K, Matsuda M, Suzuki R, Aizaki H, Sugawara F, Wakita T
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 440(4) Issue: 4 Pages: 515-20

    • DOI

      10.1016/j.bbrc.2013.09.100

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mitochondrial protein mitofusin 2 is required for NLRP3 inflammasome activation after RNA virus infection.2013

    • Author(s)
      Ichinohe T, Yamazaki T, Koshiba T, Yanagi Y.
    • Journal Title

      Proceeding National Academic Science USA

      Volume: 110(44) Issue: 44 Pages: 17963-17968

    • DOI

      10.1073/pnas.1312571110

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Transgenic mous model for the study of enterovirus 71 pathogenesis2013

    • Author(s)
      Fujii K, Nagata N, SatoY, Ong KC, Wong KT, Yamayoshi S, Shimanuki M, Shitara H, Taya C, Koike S
    • Journal Title

      Proceedings of the National Academy of Science United States of America

      Volume: 110 Issue: 36 Pages: 14753-14758

    • DOI

      10.1073/pnas.1217563110

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Erol-α and PDIs constitute a hierarchical electron transfer network of endoplasmic reticulum oxidoreductases2013

    • Author(s)
      Kazutaka Araki, Shun-ichiro Iemura, Yukiko Kamiya, David Ron, Koichi Kato, Tohru Natsume, and Kazuhiro Nagata
    • Journal Title

      The Journal of Cell Biology

      Volume: 6 Issue: 6 Pages: 861-874

    • DOI

      10.1083/jcb.201303027

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Timing of the emergence of new successful viral strains in seasonal influenza.2013

    • Author(s)
      Omori R, Sasaki A.
    • Journal Title

      Journal of Theoretical Biology

      Volume: 329 Pages: 32-38

    • DOI

      10.1016/j.jtbi.2013.03.027

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Replication of Hepatitis C Virus Genotype 3a in Cultured Cells.2013

    • Author(s)
      Saeed Mohsan
    • Journal Title

      Gastroenterology

      Volume: 144 Issue: 1 Pages: 56-58

    • DOI

      10.1053/j.gastro.2012.09.017

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Functional characterization of domains of IPS-1 using an inducible oligomerization system2013

    • Author(s)
      Takamatsu S,Onoguchi K, Onomoto K, Narita R, Takahasi K, Ishidate F, Fujiwara TK, Yoneyama M, Kato H, Fujita T
    • Journal Title

      PLoS One

      Volume: 8 Issue: 1 Pages: 1-9

    • DOI

      10.1371/journal.pone.0053578

    • NAID

      120005241348

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mutations in the putative dimer-dimer interfaces of the measles virus hemagglutinin head domain affect membrane fusion triggering.2013

    • Author(s)
      Nakashima M.
    • Journal Title

      Journal of Biological Chemistry

      Volume: 288 Issue: 12 Pages: 8085-8091

    • DOI

      10.1074/jbc.m112.427609

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mutant fusion proteins with enhanced fusion activity promote measles virus spread in human neuronal cells and brains of suckling hamsters2013

    • Author(s)
      Watanabe S. Shirogane Y. Suzuki SO, Ikegame S, Koga R, Yanagi Y
    • Journal Title

      Journal of Virology

      Volume: 87(5) Issue: 5 Pages: 2648-2659

    • DOI

      10.1128/jvi.02632-12

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Functional Comparison of SCARB2 and PSGL1 as Receptors for EV712013

    • Author(s)
      Yamayoshi, S., S. Ohka, K. Fujii and S. Koike
    • Journal Title

      Journal of Virology

      Volume: 87 Issue: 6 Pages: 3335-3347

    • DOI

      10.1128/jvi.02070-12

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] YB-1, Y-box binding protein-1, is a porter to lead influenza virus ribonucleoprotein complexes to microtubules.2012

    • Author(s)
      Kawaguchi, A., Matsumoto, K., and Nagata, K.
    • Journal Title

      Journal of Virology

      Volume: 86 Issue: 20 Pages: 11086-11095

    • DOI

      10.1128/jvi.00453-12

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Replication-uncoupled histone deposition during adenovirus DNA replication.2012

    • Author(s)
      Komatsu T.
    • Journal Title

      Journal of Virology

      Volume: 86(12) Issue: 12 Pages: 6701-6711

    • DOI

      10.1128/jvi.00380-12

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Wild-type measles virus with the hemagglutinin protein of the edmonston vaccine strain retains wild-type tropism in macaques2012

    • Author(s)
      Takeuchi K., et al.
    • Journal Title

      J.Virol.

      Volume: 86 Issue: 6 Pages: 3027-3037

    • DOI

      10.1128/jvi.06517-11

    • NAID

      120007137251

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Novel cell culture-adapted genotype 2a hepatitis C virus infectious clone2012

    • Author(s)
      Date T,Tanaka Y.
    • Journal Title

      J Virol.

      Volume: 86(19) Issue: 19 Pages: 10805-10820

    • DOI

      10.1128/jvi.07235-11

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Critical Role of an Antiviral Stress Granule Containing RIG-I and PKR in Viral Detection and Innate Immunity2012

    • Author(s)
      Onomoto K, Jogi M, Yoo J-S, Narita R, Morimoto S, Takemura A, Sambhara S, Kawaguchi A, Osari S, Nagata K, Matsumiya T, Namiki H, Yoneyama M, Fujita T
    • Journal Title

      PLoS One

      Volume: 7 Issue: 8 Pages: 1-15

    • DOI

      10.1371/journal.pone.0043031

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cooperation between different RNA virus genomes produces a new phenotype2012

    • Author(s)
      Shirogane Y, Watanabe S, Yanagi Y
    • Journal Title

      ature Communications

      Volume: 3 Issue: 1 Pages: 1235-1235

    • DOI

      10.1038/ncomms2252

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Encephalomyocarditis virus viroporin 2B activates NLRP3 inflammasome.2012

    • Author(s)
      Ito M.
    • Journal Title

      PLoS Pathogen

      Volume: 8(8) Issue: 8 Pages: e1002857-e1002857

    • DOI

      10.1371/journal.ppat.1002857

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Human SCARB2-Dependent Infection by Coxsackievirus A7, A14, and A16 and Enterovirus 712012

    • Author(s)
      Seiya Yamayoshi
    • Journal Title

      Journal of Virology

      Volume: VOL 86 Issue: 10 Pages: 5686-5696

    • DOI

      10.1128/jvi.00020-12

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The kelch repeat protein KLHDC10 regulates oxidative stress-induced ASK1 activation by suppressing PP52012

    • Author(s)
      Yusuke Sekine, Ryo Hatanaka, Takeshi Watanabe. Naoki Sono, Shun-ichiro Iemura, Tohru Natsume, Erina Kuranaga, Masayuki Miura, Kohsuke Takeda, and Hidenori Ichijo
    • Journal Title

      Molecular Cell

      Volume: 48 Issue: 5 Pages: 1-13

    • DOI

      10.1016/j.molcel.2012.09.018

    • NAID

      120007150217

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] RPA assists HSF1 access to nucleosomal DNA by recruiting histone chaperone FACT.2012

    • Author(s)
      Fujimoto M, Takaki E, Takii R, Tan K, Prakasam R, Hayashida N, Iemura S, Natsume T, Nakai A.
    • Journal Title

      Molecular Cell

      Volume: 48 Issue: 2 Pages: 182-194

    • DOI

      10.1016/j.molcel.2012.07.026

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] U7 small nuclear ribonucleoprotein represses histone gene transcription in cell cycle-arrested cells.2012

    • Author(s)
      Ideue T.
    • Journal Title

      Proc Natl Acad Sci U S A

      Volume: 109(15) Issue: 15 Pages: 5693-5698

    • DOI

      10.1073/pnas.1200523109

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Estimating the risk of re-emergence after stopping polio vaccination2012

    • Author(s)
      Sasaki, A., Haraguchi, Y., Yoshida, H.
    • Journal Title

      Frontiers in Virology

      Volume: 3(Article number:178) Pages: 178-178

    • DOI

      10.3389/fmicb.2012.00178

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Presentation] Viral budozone formation in concert with influenza virus genome transport using recycling endosomes.2016

    • Author(s)
      Kuroki T, Nagata K, Kawaguchi A.
    • Organizer
      The 64th Annual Meeting of the Japanese Society for Virology
    • Place of Presentation
      札幌コンベンションセンター・北海道・札幌
    • Year and Date
      2016-10-23
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] In situ detection of M1-NS2 complex formation essential for nuclear export of the influenza virus genome.2016

    • Author(s)
      Yamashita S, Asaka MN, Nagata K, Kawaguchi A.
    • Organizer
      The 64th Annual Meeting of the Japanese Society for Virology
    • Place of Presentation
      札幌コンベンションセンター・北海道・札幌
    • Year and Date
      2016-10-23
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Influenza A virus infection induces Caspase-1-dependent cell death with pro-inflammatory cytokines in human lung epithelial cells.2016

    • Author(s)
      Lee SJ, Nagata K, Kawaguchi A.
    • Organizer
      The 64th Annual Meeting of the Japanese Society for Virology
    • Place of Presentation
      札幌コンベンションセンター・北海道・札幌
    • Year and Date
      2016-10-23
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Sensing viral RNA and activation of antiviral responses2016

    • Author(s)
      Takashi Fujita
    • Organizer
      Molecular Basis of Virus-Host interactions
    • Place of Presentation
      ACU・北海道・札幌
    • Year and Date
      2016-10-22
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Paramyxovirus entry and receptors2016

    • Author(s)
      Yusuke Yanagi
    • Organizer
      Molecular Basis of Virus-Host interactions
    • Place of Presentation
      ACU・北海道・札幌
    • Year and Date
      2016-10-22
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Influenza virus induces cholesterol-enriched endocytic recycling compartments for budozone formation through centrosome maturation.2015

    • Author(s)
      Kawaguchi A, Hirohama M, Nagata K.
    • Organizer
      The 63rd Annual Meeting of the Japanese Society for Virology
    • Place of Presentation
      福岡国際会議場(福岡)
    • Year and Date
      2015-11-23
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Multimerization of hepatitis B virus core protein regulated by microtubules2015

    • Author(s)
      Iwamoto M, Watashi K, Sugiyama M, Suzuki R, Aizaki H, Tanaka T, Mizokami M, Ohtani N, Koiwai O, Wakita T.
    • Organizer
      The 63rd Annual Meeting of the Japanese Society for Virology
    • Place of Presentation
      福岡国際会議場(福岡)
    • Year and Date
      2015-11-23
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] RNA replicon as proper noun2015

    • Author(s)
      Nagata K.
    • Organizer
      The 63rd Annual Meeting of the Japanese Society for Virology
    • Place of Presentation
      福岡国際会議場(福岡)
    • Year and Date
      2015-11-22
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Development of a new animal model for enterovirus 71 infection2015

    • Author(s)
      Koike S.
    • Organizer
      The 63rd Annual Meeting of the Japanese Society for Virology
    • Place of Presentation
      福岡国際会議場(福岡)
    • Year and Date
      2015-11-22
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] A novel function of human Pumilio proteins in innate immune responses2015

    • Author(s)
      Narita R, Yoneyama M, Kato H, Fujita T.
    • Organizer
      The 63rd Annual Meeting of the Japanese Society for Virology
    • Place of Presentation
      福岡国際会議場(福岡)
    • Year and Date
      2015-11-22
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Identification of a cellular protein contributing to the efficient growth of Murine gammaherpesvirus 682015

    • Author(s)
      Ohno S, Yanagi Y.
    • Organizer
      The 63rd Annual Meeting of the Japanese Society for Virology
    • Place of Presentation
      福岡国際会議場(福岡)
    • Year and Date
      2015-11-22
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Novel host factor-dependent influenza A virus vRNA synthesis from its cRNA.2015

    • Author(s)
      Sugiyama K, Kawaguchi A, Okuwaki M, Nagata K.
    • Organizer
      The 14th Awaji International Forum on Infection and Immunity
    • Place of Presentation
      淡路夢舞台国際会議場(淡路)
    • Year and Date
      2015-09-09
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Intracellular trafficking of influenza virus genome mediated by endocytic recycling compartments located at the centrosome.2015

    • Author(s)
      Kawaguchi A, Hirohama M, Nagata K.
    • Organizer
      The 16th International Negative Strand Virus Meeting
    • Place of Presentation
      シエナ大学(シエナ)
    • Year and Date
      2015-06-15
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 中心体の機能制御を介したインフルエンザウイルスゲノムの細胞内輸送機構2014

    • Author(s)
      川口敦史、広浜美香子、永田恭介
    • Organizer
      第62回日本ウイルス学会学術集会
    • Place of Presentation
      横浜
    • Year and Date
      2014-11-10 – 2014-11-12
    • Related Report
      2014 Annual Research Report
  • [Presentation] Host factor-dependent influenza virus genome replication2014

    • Author(s)
      Nagata K.
    • Organizer
      第62回日本ウイルス学会学術集会
    • Place of Presentation
      横浜
    • Year and Date
      2014-11-10 – 2014-11-12
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] EV71の非神経組織での増殖はI型インターフェロンにより抑制されている2014

    • Author(s)
      藤井健、小池智
    • Organizer
      第62回日本ウイルス学会学術集会
    • Place of Presentation
      横浜
    • Year and Date
      2014-11-10 – 2014-11-12
    • Related Report
      2014 Annual Research Report
  • [Presentation] Aryl hydrocarbon receptorによる脂肪滴形成及びC型肝炎ウイルス粒子構築の制御2014

    • Author(s)
      大橋啓史、渡士幸一、中嶋翔、金ソルイ、鈴木亮介、相崎英樹、紙透伸治、菅原二三男、脇田隆字
    • Organizer
      第62回日本ウイルス学会学術集会
    • Place of Presentation
      横浜
    • Year and Date
      2014-11-10 – 2014-11-12
    • Related Report
      2014 Annual Research Report
  • [Presentation] 麻疹ウイルス増殖におけるCofilinの機能2014

    • Author(s)
      古賀律子、大野真治、柳雄介
    • Organizer
      第62回日本ウイルス学会学術集会
    • Place of Presentation
      横浜
    • Year and Date
      2014-11-10 – 2014-11-12
    • Related Report
      2014 Annual Research Report
  • [Presentation] Pharmacoproteomics: Absolute quantification of protein interactions for drug target identification2013

    • Author(s)
      Natsume T.
    • Organizer
      KHUPO 13th Annual International Proteomics Conference
    • Place of Presentation
      ソウル(韓国)
    • Year and Date
      2013-03-29
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Measles virus entry and fusion.2013

    • Author(s)
      Yanagi Y.
    • Organizer
      The 2nd Meeting on RNA and Biofunctions-ASIA Study “RNA Biofunctions and Viruses”
    • Place of Presentation
      博多
    • Year and Date
      2013-01-10
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Host factor-dependent RNA replication of the influenza virus genome.2013

    • Author(s)
      永田恭介
    • Organizer
      The 12th Awaji International Forum on Infection and Immunity.
    • Place of Presentation
      淡路
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] エンテロウイルス71受容体の解析2013

    • Author(s)
      小池智
    • Organizer
      第61回日本ウイルス学会学術集会
    • Place of Presentation
      神戸
    • Related Report
      2013 Annual Research Report
  • [Presentation] C型肝炎ウイルス遺伝子型3aの培養細胞におけるウイルス感染実験系の確立2013

    • Author(s)
      金ソルイ、伊達朋子、横川寛、河野環、相崎英樹、脇田隆字
    • Organizer
      第61回日本ウイルス学会学術集会
    • Place of Presentation
      神戸
    • Related Report
      2013 Annual Research Report
  • [Presentation] 膜融合能が亢進した麻疹ウイルスはIFN betaを強く誘導する2013

    • Author(s)
      渡辺俊平、白銀勇太、大野真治、柳雄介
    • Organizer
      第61回日本ウイルス学会学術集会
    • Place of Presentation
      神戸
    • Related Report
      2013 Annual Research Report
  • [Presentation] PKR活性化制御を介するシクロフィリン阻害剤の新たな抗C型肝炎ウイルス作用機序2013

    • Author(s)
      大東卓史、渡士幸一、Ann Sluder、中嶋翔、Katyna Borroto-Esoda、藤田尚志、脇田隆字
    • Organizer
      第61回日本ウイルス学会学術集会
    • Place of Presentation
      神戸
    • Related Report
      2013 Annual Research Report
  • [Presentation] 薬剤耐性ウイルスが出現しない抗インフルエンザウイルス薬開発に向けた宿主因子依存性ウイルスRNAゲノムの複製転写機構2012

    • Author(s)
      永田恭介
    • Organizer
      第35回日本分子生物学会年会
    • Place of Presentation
      福岡
    • Year and Date
      2012-12-11
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Scavenger receptor B2-transgenic mouse model for EV71 infection.2012

    • Author(s)
      Koike S.
    • Organizer
      Singapore International Conference on Dengue and Emerging Infection.
    • Place of Presentation
      シンガポール
    • Year and Date
      2012-11-23
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Purmacoproteomics: Target ID and Target Discovery2012

    • Author(s)
      夏目 徹
    • Organizer
      ChemBioChem Symosium
    • Place of Presentation
      京都
    • Year and Date
      2012-10-31
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Paramyxovirus entry and fusion.2012

    • Author(s)
      Yanagi Y.
    • Organizer
      The 34th Naito Conference on “Infection, Immunity and their Control for Health: Mucosal Barrier, Pathogen and Vaccine”
    • Place of Presentation
      札幌
    • Year and Date
      2012-10-17
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Scavenger receptor B2 is a receptor for Enterovirus 71.2012

    • Author(s)
      Koike S.
    • Organizer
      The XIth Awaji International Forum on Infection and Immunity.
    • Place of Presentation
      淡路
    • Year and Date
      2012-09-13
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Cytoplasmic sensing of viral RNA by RIG-I-like receptors.2012

    • Author(s)
      Fujita T.
    • Organizer
      Non-self RNA sensing in virus infected cells and activation of antiviral immunity.
    • Place of Presentation
      トュールーズ(フランス)
    • Year and Date
      2012-08-27
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] ウイルス研究が育んだ現代生命科学2012

    • Author(s)
      永田恭介
    • Organizer
      第9回ウイルス学キャンプin湯河原
    • Place of Presentation
      熱海
    • Year and Date
      2012-07-10
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Adaptive light absorption spectra for protection and photosynthesis in layered plant community.2012

    • Author(s)
      Sasaki A.
    • Organizer
      ASLO Aquatic Sciences Meeting
    • Place of Presentation
      大津
    • Year and Date
      2012-07-08
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Remarks] ウイルス感染現象における宿主細胞コンピテンシーの分子基盤

    • URL

      http://www.md.tsukuba.ac.jp/basic-med/infcompetence/

    • Related Report
      2016 Annual Research Report 2014 Annual Research Report 2012 Annual Research Report
  • [Remarks] ウイルス感染現象における宿主細胞コンピテンシーの分子基盤

    • URL

      http://www.md.tsukuba.ac.jp/basic-med/infcompetence/index.html

    • Related Report
      2015 Annual Research Report
  • [Remarks] ウイルス感染現象における宿主細胞コンピテンシーの分子基盤

    • URL

      http://www.md.tsukuba.ac.jp/basic-med/infcompetence/index.html

    • Related Report
      2013 Annual Research Report
  • [Funded Workshop] Molecular Basis of Virus-Host interactions2016

    • Place of Presentation
      ACU・北海道・札幌
    • Year and Date
      2016-10-22
    • Related Report
      2016 Annual Research Report
  • [Funded Workshop] The 14th Awaji International Forum on Infection and Immunity2015

    • Place of Presentation
      淡路夢舞台国際会議場(淡路)
    • Year and Date
      2015-09-08
    • Related Report
      2015 Annual Research Report

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Published: 2012-11-27   Modified: 2023-03-16  

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