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Multidisciplinary research on autophagy: from molecular mechanisms to disease states

Administrative Group

Project AreaMultidisciplinary research on autophagy: from molecular mechanisms to disease states
Project/Area Number 25111001
Research Category

Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

Allocation TypeSingle-year Grants
Review Section Biological Sciences
Research InstitutionThe University of Tokyo

Principal Investigator

Mizushima Noboru  東京大学, 大学院医学系研究科(医学部), 教授 (10353434)

Co-Investigator(Kenkyū-buntansha) 斉木 臣二  順天堂大学, 医学部, 准教授 (00339996)
野田 展生  公益財団法人微生物化学研究会, 微生物化学研究所, 主席研究員 (40396297)
吉森 保  大阪大学, 生命機能研究科, 教授 (60191649)
小松 雅明  新潟大学, 医歯学系, 教授 (90356254)
中戸川 仁  東京工業大学, 生命理工学院, 准教授 (90414010)
Co-Investigator(Renkei-kenkyūsha) IWAI Kazuhiro  京都大学, 大学院医学研究科, 教授 (60252459)
UCHIYAMA Yasuo  順天堂大学, 老人性疾患病態・治療研究センター, センター長 (10049091)
OHSUMI Yoshinori  東京工業大学, 科学技術創成研究院, 栄誉教授 (30114416)
OHNO Hiroshi  理化学研究所, 総合生命医科学研究センター, グループディレクター (50233226)
KOMINAMI Eiki  順天堂大学, 学長特別補佐 (10035496)
TANAKA Keiji  東京都医学総合研究所, 理事長 (10108871)
SATO Shigeto  順天堂大学, 医学部, 准教授 (00445537)
Research Collaborator SUGAWARA Hideaki  国立遺伝学研究所, 特任教授 (80231372)
Project Period (FY) 2013-06-28 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥115,050,000 (Direct Cost: ¥88,500,000、Indirect Cost: ¥26,550,000)
Fiscal Year 2017: ¥10,270,000 (Direct Cost: ¥7,900,000、Indirect Cost: ¥2,370,000)
Fiscal Year 2016: ¥14,690,000 (Direct Cost: ¥11,300,000、Indirect Cost: ¥3,390,000)
Fiscal Year 2015: ¥9,230,000 (Direct Cost: ¥7,100,000、Indirect Cost: ¥2,130,000)
Fiscal Year 2014: ¥9,230,000 (Direct Cost: ¥7,100,000、Indirect Cost: ¥2,130,000)
Fiscal Year 2013: ¥71,630,000 (Direct Cost: ¥55,100,000、Indirect Cost: ¥16,530,000)
Keywordsオートファジー / 細胞内分解 / リソソーム / 蛋白質 / 細胞・組織 / 生理学 / 遺伝子 / 脳神経疾患 / 神経変性疾患
Outline of Final Research Achievements

This Grant-in-Aid for Scientific Research on Innovative Areas was established to promote multidisciplinary research on autophagy by coordinating in vitro reconstitution biology, structural biology, cell biology, genetics of model organisms, and human pathophysiology. This "Administrative Group" multilaterally supported and coordinated our studies in this Innovative Area; supporting our annual meetings and international symposium. On our website, we opened the Autophagy Forum, which is a discussion forum for our research outcomes. Autophagy protocols have also become available on the website.

Report

(6 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Annual Research Report
  • 2015 Annual Research Report
  • 2014 Annual Research Report
  • 2013 Annual Research Report
  • Research Products

    (200 results)

All 2018 2017 2016 2015 2014 2013 Other

All Journal Article (74 results) (of which Int'l Joint Research: 4 results,  Peer Reviewed: 40 results,  Open Access: 17 results,  Acknowledgement Compliant: 9 results) Presentation (113 results) (of which Int'l Joint Research: 35 results,  Invited: 102 results) Book (5 results) Remarks (6 results) Patent(Industrial Property Rights) (1 results) Funded Workshop (1 results)

  • [Journal Article] A brief history of autophagy from cell biology to physiology and disease.2018

    • Author(s)
      Mizushima Noboru
    • Journal Title

      Nat. Cell Biol.

      Volume: 印刷中

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Monitoring and Measuring Autophagy2017

    • Author(s)
      Yoshii Saori R.、Mizushima Noboru
    • Journal Title

      Int. J. Mol. Sci.

      Volume: 18 Issue: 9 Pages: 1865-1865

    • DOI

      10.3390/ijms18091865

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Autophagy-monitoring and autophagy-deficient mice.2017

    • Author(s)
      Kuma A, Komatsu M, Mizushima N.
    • Journal Title

      Autophagy

      Volume: 13 Issue: 10 Pages: 1619-1628

    • DOI

      10.1080/15548627.2017.1343770

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The ULK complex initiates autophagosome formation at phosphatidylinositol synthase-enriched ER subdomains2017

    • Author(s)
      Nishimura Taki、Mizushima Noboru
    • Journal Title

      Autophagy

      Volume: 13 Issue: 10 Pages: 1795-1796

    • DOI

      10.1080/15548627.2017.1358344

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ATG conjugation-dependent degradation of the inner autophagosomal membrane is a key step for autophagosome maturation2017

    • Author(s)
      Koyama-Honda Ikuko、Tsuboyama Kotaro、Mizushima Noboru
    • Journal Title

      Autophagy

      Volume: 13 Issue: 7 Pages: 1252-1253

    • DOI

      10.1080/15548627.2017.1319041

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Transgenic rescue of Atg5-null mice from neonatal lethality with neuron-specific expression of ATG5: Systemic analysis of adult Atg5-deficient mice.2017

    • Author(s)
      Yoshii SR, Kuma A, Mizushima N.
    • Journal Title

      Autophagy

      Volume: 13 Issue: 4 Pages: 763-764

    • DOI

      10.1080/15548627.2017.1280221

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A new probe to measure autophagic flux in vitro and in vivo.2017

    • Author(s)
      Morishita H, Kaizuka T, Hama Y, Mizushima N.
    • Journal Title

      Autophagy

      Volume: 13 Issue: 4 Pages: 757-758

    • DOI

      10.1080/15548627.2016.1278094

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] オートファジー総説のメタレビュー2017

    • Author(s)
      水島昇
    • Journal Title

      実験医学

      Volume: 35 Pages: 2466-2475

    • Related Report
      2017 Annual Research Report
  • [Journal Article] オートファジー関連の国内外研究会2017

    • Author(s)
      水島昇、吉森保
    • Journal Title

      実験医学

      Volume: 35 Pages: 2476-2482

    • Related Report
      2017 Annual Research Report
  • [Journal Article] オートファジー創薬と課題2017

    • Author(s)
      水島昇
    • Journal Title

      実験医学

      Volume: 35 Pages: 2656-2661

    • Related Report
      2017 Annual Research Report
  • [Journal Article] The exponential growth of autophagy-related research: from the humble yeast to the Nobel Prize.2017

    • Author(s)
      Mizushima, N.
    • Journal Title

      FEBS Lett.

      Volume: 591 Issue: 5 Pages: 681-689

    • DOI

      10.1002/1873-3468.12594

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Autophagy in the liver: functions in health and disease.2017

    • Author(s)
      Ueno T, Komatsu M
    • Journal Title

      Nat Rev Gastroenterol Hepatol.

      Volume: 14 Issue: 3 Pages: 170-184

    • DOI

      10.1038/nrgastro.2016.185

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] New insights into autophagosome-lysosome fusion.2017

    • Author(s)
      Nakamura S, Yoshimori T.
    • Journal Title

      J Cell Science. 130. 2017. p1209-1216

      Volume: 130 Issue: 7 Pages: 1209-1216

    • DOI

      10.1242/jcs.196352

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Structural biology of the Cvt pathway2017

    • Author(s)
      Yamasaki A, Noda NN
    • Journal Title

      Journal of Molecular Biology

      Volume: 429 Issue: 4 Pages: 531-542

    • DOI

      10.1016/j.jmb.2017.01.003

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] オートファジー研究の課題2017

    • Author(s)
      久万亜紀子、水島昇
    • Journal Title

      メディカルサイエンスダイジェスト

      Volume: 43 Pages: 2-4

    • Related Report
      2016 Annual Research Report
  • [Journal Article] オートファジーの分子機構と生理的意義2017

    • Author(s)
      守田啓悟、水島昇
    • Journal Title

      シェネラー

      Volume: 101 Pages: 17-22

    • NAID

      130007770905

    • Related Report
      2016 Annual Research Report
  • [Journal Article] LAP (LC3-associated phagocytosis):オートファジー因子を用いる特殊なファーゴサイトーシス2017

    • Author(s)
      吉井紗織、水島昇
    • Journal Title

      最新医学

      Volume: 72 Pages: 256-260

    • Related Report
      2016 Annual Research Report
  • [Journal Article] オートファジー関連神経変性の分子基盤とモデル動物2017

    • Author(s)
      森下英晃、水島昇
    • Journal Title

      最新医学

      Volume: 72 Pages: 184-192

    • Related Report
      2016 Annual Research Report
  • [Journal Article] オートファジーの分子機構とその破綻2017

    • Author(s)
      川端剛、吉森保
    • Journal Title

      再生医療

      Volume: 68 Pages: 6-21

    • NAID

      40021152386

    • Related Report
      2016 Annual Research Report
  • [Journal Article] オートファジー研究の現状と問題点2017

    • Author(s)
      吉森保、服部信孝、水島昇
    • Journal Title

      最新醫學

      Volume: 920 Pages: 163-176

    • Related Report
      2016 Annual Research Report
  • [Journal Article] オートファジー研究の意義と発展2017

    • Author(s)
      吉森保
    • Journal Title

      科学

      Volume: 87 Pages: 61-67

    • Related Report
      2016 Annual Research Report
  • [Journal Article] Regulation of lysosomal phosphoinositide balance by INPP5E is essential for autophagosome-lysosome fusion.2016

    • Author(s)
      Nakamura S, Hasegawa J, Yoshimori T.
    • Journal Title

      Autophagy

      Volume: 12 Issue: 12 Pages: 2500-2501

    • DOI

      10.1080/15548627.2016.1234568

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Phospholipids in Autophagosome Formation and Fusion.2016

    • Author(s)
      Martens S, Nakamura S, Yoshimori T.
    • Journal Title

      J Mol Biol.

      Volume: 428 Issue: 24 Pages: 4819-4827

    • DOI

      10.1016/j.jmb.2016.10.029

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)2016

    • Author(s)
      Klionsky DJ., Abdelmohsen K., Abe A., Abedin MJ.,Inomata M., et al.
    • Journal Title

      Autophagy

      Volume: 12(1) Issue: 1 Pages: 1-222

    • DOI

      10.1080/15548627.2015.1100356

    • Related Report
      2016 Annual Research Report 2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Eating the ER and the nucleus for survival under starvation conditions.2016

    • Author(s)
      Nakatogawa H.
    • Journal Title

      Molecular & Cellular Oncology

      Volume: 3 Issue: 2 Pages: e1073416-e1073416

    • DOI

      10.1080/23723556.2015.1073416

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] オートファジーと老化2016

    • Author(s)
      森下英晃、水島昇
    • Journal Title

      日本臨床(特集「老化制御と疾患」)

      Volume: 74 Pages: 1461-1468

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] オートファジーと発生2016

    • Author(s)
      吉井紗織、水島昇
    • Journal Title

      臨床免疫・アレルギー

      Volume: 66 Pages: 309-313

    • Related Report
      2016 Annual Research Report
  • [Journal Article] オートファジーの分子機構解明―2016年ノーベル生理学・医学賞によせて2016

    • Author(s)
      吉森保
    • Journal Title

      医学のあゆみ

      Volume: 259 Pages: 1241-1244

    • Related Report
      2016 Annual Research Report
  • [Journal Article] 2016年ノーベル賞記念フォーラム 発見の喜びをともにした仲間が語る 大隅博士とオートファジー2016

    • Author(s)
      吉森保
    • Journal Title

      実験医学

      Volume: 34 Pages: 3163-3165

    • Related Report
      2016 Annual Research Report
  • [Journal Article] 解説:2016年ノーベル生理学・医学賞 大隅良典先生のノーベル賞受賞を祝って2016

    • Author(s)
      吉森保
    • Journal Title

      現代化学

      Volume: 549 Pages: 26-28

    • Related Report
      2016 Annual Research Report
  • [Journal Article] 発癌とオートファジー(Interpretation of paradoxical role for autophagy in tumorigenesis). . 73(2). 2016. p169-1742016

    • Author(s)
      川端剛、吉森保
    • Journal Title

      肝胆膵

      Volume: 73 Pages: 169-174

    • Related Report
      2016 Annual Research Report
  • [Journal Article] オートファジーの分子メカニズム2016

    • Author(s)
      小谷哲也、中戸川仁
    • Journal Title

      臨床免疫・アレルギー科

      Volume: 66 Pages: 301-308

    • Related Report
      2016 Annual Research Report
  • [Journal Article] オートファジー関連遺伝子の発見2016

    • Author(s)
      中戸川仁
    • Journal Title

      Medical Science Digest

      Volume: 42 Pages: 558-560

    • Related Report
      2016 Annual Research Report
  • [Journal Article] Atg101: Not Just an Accessory Subunit in the Autophagy-initiation Complex2016

    • Author(s)
      Noda, N.N., Mizushima, N.
    • Journal Title

      Cell Structure and Function

      Volume: 41 Issue: 1 Pages: 13-20

    • DOI

      10.1247/csf.15013

    • NAID

      130005126756

    • ISSN
      0386-7196, 1347-3700
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Nbr1, a Receptor for ESCRT-Dependent Endosomal Microautophagy in Fission Yeast.2015

    • Author(s)
      Mizushima, N.
    • Journal Title

      Mol. Cell

      Volume: 59 Issue: 6 Pages: 887-889

    • DOI

      10.1016/j.molcel.2015.09.004

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Beyond starvation: An update on the autophagic machinery and its functions.2015

    • Author(s)
      Kawabata T, Yoshimori T
    • Journal Title

      J. Mol. Cell Cardiol.

      Volume: - Pages: 2-10

    • DOI

      10.1016/j.yjmcc.2015.12.005

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Autophagy and autophagy-related proteins in the immune system.2015

    • Author(s)
      Shibutani ST, Saitoh T, Nowag H, Munz C, Yoshimori T
    • Journal Title

      Nat Immunol

      Volume: 16 Issue: 10 Pages: 1014-1024

    • DOI

      10.1038/ni.3273

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Hyperuricemia-induced inflammasome and kidney diseases.2015

    • Author(s)
      Isaka Y, Takabatake Y, Takahashi A, Saitoh T, Yoshimori T.
    • Journal Title

      Nephrol. Dial. Transplant.

      Volume: - Issue: 6 Pages: 890-896

    • DOI

      10.1093/ndt/gfv024

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Selective autophagy: Lysophagy2015

    • Author(s)
      Hasegawa J, Maejima I, Iwamoto R, Yoshimori T
    • Journal Title

      Methods

      Volume: 75 Pages: 128-132

    • DOI

      10.1016/j.ymeth.2014.12.014

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Open and closed HORMAs regulate autophagy initiation.2015

    • Author(s)
      Suzuki, H., Kaizuka, T., Mizushima, N., Noda, N.N.
    • Journal Title

      Autophagy

      Volume: 11 Issue: 11 Pages: 2123-2124

    • DOI

      10.1080/15548627.2015.1091144

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Reticulophagy and nucleophagy: New findings and unsolved issues2015

    • Author(s)
      Nakatogawa H., Mochida K.
    • Journal Title

      Autophagy

      Volume: 11 Issue: 12 Pages: 2377-2378

    • DOI

      10.1080/15548627.2015.1106665

    • Related Report
      2015 Annual Research Report
    • Acknowledgement Compliant
  • [Journal Article] Appetite for ER/nucleus destruction.2015

    • Author(s)
      Mochida K., Nakatogawa H.
    • Journal Title

      Cell Cycle

      Volume: 14 Issue: 20 Pages: 3209-3210

    • DOI

      10.1080/15384101.2015.1084206

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Regulated degradation: controlling the stability of autophagy gene transcripts.2015

    • Author(s)
      Nakatogawa H.
    • Journal Title

      Dev. Cell

      Volume: 34 Issue: 2 Pages: 132-134

    • DOI

      10.1016/j.devcel.2015.07.002

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] オートファジーの分子基盤2015

    • Author(s)
      松井貴英、水島昇
    • Journal Title

      内分泌・糖尿病・代謝内科

      Volume: 40 Pages: 477-482

    • NAID

      40020529498

    • Related Report
      2015 Annual Research Report
  • [Journal Article] オートファジーによる細胞内分解2015

    • Author(s)
      水島昇
    • Journal Title

      Therapeutic Research

      Volume: 36 Pages: 633-636

    • Related Report
      2015 Annual Research Report
  • [Journal Article] オートファジーの膜動態分子機構と病態への関与.2015

    • Author(s)
      川端剛、吉森保
    • Journal Title

      The Lung

      Volume: 23 Pages: 172-177

    • Related Report
      2015 Annual Research Report
    • Open Access
  • [Journal Article] Autophagy: Mechanisms and Membrane Origins2015

    • Author(s)
      渋谷周作、吉森保
    • Journal Title

      MEMBRANE

      Volume: 40 Issue: 1 Pages: 9-20

    • DOI

      10.5360/membrane.40.9

    • NAID

      130005069461

    • ISSN
      0385-1036, 1884-6440
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Structure and Function of Atg101-Atg13 HORMA Heterodimer: Insight into Mammalian Autophagy Initiation2015

    • Author(s)
      鈴木浩典、野田展生
    • Journal Title

      Nihon Kessho Gakkaishi

      Volume: 57 Issue: 6 Pages: 324-330

    • DOI

      10.5940/jcrsj.57.324

    • NAID

      130005115747

    • ISSN
      0369-4585, 1884-5576
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Structural Basis of Starvation-induced Assembly of the Autophagy Initiation Complex2015

    • Author(s)
      藤岡優子、野田展生
    • Journal Title

      Nihon Kessho Gakkaishi

      Volume: 57 Issue: 3 Pages: 191-197

    • DOI

      10.5940/jcrsj.57.191

    • NAID

      130005085906

    • ISSN
      0369-4585, 1884-5576
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] LC3- and p62-based biochemical methods for the analysis of autophagy progression in mammalian cells2015

    • Author(s)
      Jiang, P., Mizushima, N.
    • Journal Title

      Methods

      Volume: 75 Pages: 13-18

    • DOI

      10.1016/j.ymeth.2014.11.021

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Autophagy machinery in the context of mammalian mitophagy2015

    • Author(s)
      Saori R. Yoshii, Noboru Mizushima
    • Journal Title

      Biochemica et Biophysica Acta - Molecular Cell Research

      Volume: 未定 Issue: 10 Pages: 2797-2801

    • DOI

      10.1016/j.bbamcr.2015.01.013

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] mTOR複合体・AMPKとオートファジー2015

    • Author(s)
      栗川義峻、水島昇
    • Journal Title

      The Lipid

      Volume: 26 Pages: 40-47

    • Related Report
      2014 Annual Research Report
  • [Journal Article] Identification of novel biomarkers for Parkinson's disease by metabolomic technologies.2015

    • Author(s)
      Hatano T, Saiki S, Okuzumi A, Mohney RP, Hattori N.
    • Journal Title

      J Neurol Neurosurg Psychiatry.

      Volume: jnnp-2014 Issue: 3 Pages: 2014-309676

    • DOI

      10.1136/jnnp-2014-309676

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] High frequency of beta-propeller protein-associated neurodegeneration (BPAN) among patients with intellectual disability and young-onset parkinsonism.2015

    • Author(s)
      Nishioka K, Oyama G, Yoshino H, Li Y, Matsushima T, Takeuchi C, Mochizuki Y, Mori-Yoshimura M, Murata M, Yamasita C, Nakamura N, Konishi Y, Ohi K, Ichikawa K, Terada T, Obi T, Funayama M, Saiki S, Hattori N.
    • Journal Title

      Neurobiol Aging.

      Volume: S0197 Issue: 5 Pages: 54-58

    • DOI

      10.1016/j.neurobiolaging.2015.01.020

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] CHCHD2 mutations in autosomal dominant late-onset Parkinson’s disease: a genome-wide linkage and sequencing study.2015

    • Author(s)
      Funayama M, Ohe K, Amo T, Furuya N, Yamaguchi J, Saiki S, Yuanzhe L, Ogaki K, Ando M, Yoshinon H, Tomiyama H, Nishioka K, Hasegawa K, Saiki H, Satake W, Mogushi K, Sasaki R, Kokubo Y, Kuzuhara S, Toda T, Mizuno Y, Uchiyama Y, Ohno K, Hattori N.
    • Journal Title

      Lancet Neurol

      Volume: 14 Issue: 3 Pages: 274-282

    • DOI

      10.1016/s1474-4422(14)70266-2

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] ATG8 localization in apicomplexan parasites: Apicoplast and more?2014

    • Author(s)
      Mizushima, N., Sahani, M.H.
    • Journal Title

      Autophagy

      Volume: 10 Issue: 9 Pages: 1487-1494

    • DOI

      10.4161/auto.32183

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Sugar modification inhibits autophagosome-lysosome fusion.2014

    • Author(s)
      Mizushima, N.
    • Journal Title

      Nat. Cell Biol.

      Volume: 16 Issue: 12 Pages: 1132-1133

    • DOI

      10.1038/ncb3078

    • Related Report
      2014 Annual Research Report
  • [Journal Article] 栄養代謝とオートファジー2014

    • Author(s)
      久万亜紀子、水島昇
    • Journal Title

      生体の科学

      Volume: 65 Pages: 339-343

    • Related Report
      2014 Annual Research Report
  • [Journal Article] パーキン依存的ミトコンドリア外膜タンパク質分解2014

    • Author(s)
      吉井紗織、水島昇
    • Journal Title

      医学のあゆみ

      Volume: 250 Pages: 473-478

    • Related Report
      2014 Annual Research Report
  • [Journal Article] イトファゴソーム形成と不良ミトコンドリアの取り込み ~マイトファジーの二段階認識説~2014

    • Author(s)
      板倉英祐、水島昇
    • Journal Title

      医学のあゆみ

      Volume: 250 Pages: 495-499

    • Related Report
      2014 Annual Research Report
  • [Journal Article] 水晶体におけるオートファジーの生理的意義と白内障との関連2014

    • Author(s)
      森下英晃、水島昇
    • Journal Title

      白内障学会誌

      Volume: 26 Pages: 30-32

    • NAID

      130004708178

    • Related Report
      2014 Annual Research Report
  • [Journal Article] オートファジーと疾患2014

    • Author(s)
      吉森保
    • Journal Title

      プログレッシブ 生命科学(第1版)南山堂

      Volume: 1 Pages: 70-78

    • Related Report
      2014 Annual Research Report
  • [Journal Article] Autophagy: close contact keeps out the uninvited2014

    • Author(s)
      Nakatogawa H, Ohsumi Y
    • Journal Title

      Curr. Biol.

      Volume: 24 Issue: 12 Pages: 560-562

    • DOI

      10.1016/j.cub.2014.05.013

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] オートファジーにおける二つのユビキチン様結合システムの役割と作動機構2014

    • Author(s)
      中戸川仁
    • Journal Title

      生化学

      Volume: 86 Pages: 441-451

    • NAID

      40020200933

    • Related Report
      2014 Annual Research Report
  • [Journal Article] P150glued-associated disorders are caused by activation of intrinsic apoptotic pathway.2014

    • Author(s)
      Ishikawa K, Saiki S, Furuya N, Yamada D, Imamichi Y, Li Y, Kawajiri S, Sasaki H, Koike M, Tsuboi Y, Hattori N.
    • Journal Title

      PLoS One.

      Volume: 9 Issue: 4 Pages: e94645-e94645

    • DOI

      10.1371/journal.pone.0094645

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Structure and molecular function of autophagosome-forming factors2014

    • Author(s)
      野田展生、稲垣冬彦
    • Journal Title

      Leading Author's

      Volume: 3 Pages: e012

    • DOI

      10.7875/leading.author.3.e012

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] At the end of the autophagic road: an emerging understanding of lysosomal functions in autophagy.2014

    • Author(s)
      Shen, H.M., Mizushima, N.
    • Journal Title

      Trends Biochem. Sci.

      Volume: 39 Issue: 2 Pages: 61-71

    • DOI

      10.1016/j.tibs.2013.12.001

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Autophagy and human diseases.2014

    • Author(s)
      Jiang, P., Mizushima, N.
    • Journal Title

      Cell Res.

      Volume: 24 Issue: 1 Pages: 69-79

    • DOI

      10.1038/cr.2013.161

    • NAID

      40016082506

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A current perspective of autophagosome biogenesis.2014

    • Author(s)
      Shibutani ST, Yoshimori T
    • Journal Title

      Cell Res.

      Volume: 24 Issue: 1 Pages: 58-68

    • DOI

      10.1038/cr.2013.159

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 糖尿病とオートファジー2013

    • Author(s)
      久万亜紀子、水島昇
    • Journal Title

      Diabetes Frontier

      Volume: 25 Pages: 493-500

    • Related Report
      2013 Annual Research Report
  • [Journal Article] オートファジー制御と老化2013

    • Author(s)
      内藤貴子、水島昇
    • Journal Title

      内分泌・糖尿病・代謝内科

      Volume: 37 Pages: 191-197

    • NAID

      40019798210

    • Related Report
      2013 Annual Research Report
  • [Journal Article] オートファジーと老化・寿命(増刊号「老化・寿命研究の最前線」)2013

    • Author(s)
      森下英晃、水島昇
    • Journal Title

      実験医学

      Volume: 31 Pages: 3225-3231

    • Related Report
      2013 Annual Research Report
  • [Journal Article] The autophagosome: origins unknown, biogenesis complex2013

    • Author(s)
      Lamb CA, Yoshimori T, Tooze SA.
    • Journal Title

      Nat Rev Mol Cell Biol.

      Volume: 14 Issue: 12 Pages: 759-774

    • DOI

      10.1038/nrm3696

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Functions of autophagy in normal and diseased liver.2013

    • Author(s)
      Czaja MJ, Ding WX, Donohue TM Jr, Friedman SL, Kim JS, Komatsu M, Lemasters JJ, Lemoine A, Lin JD, Ou JH, Perlmutter DH, Randall G, Ray RB, Tsung A, Yin XM
    • Journal Title

      Autophagy

      Volume: 9 Issue: 8 Pages: 1131-1158

    • DOI

      10.4161/auto.25063

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Presentation] Physiological roles and molecular mechanisms of autophagy2018

    • Author(s)
      Noboru Mizushima
    • Organizer
      The 1st JCS Council Forum on Basic CadioVascular Research
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] The life of the autophagosome: Formation and maturation2018

    • Author(s)
      Noboru Mizushima
    • Organizer
      The 6th Bioscience and Biotechnology International Symposium
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Autophagy: From Yeast to Nobel Prize2018

    • Author(s)
      Noboru Mizushima
    • Organizer
      Gordon Research Seminar: Autophagy in Stress, Development & Disease
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Novel Roles of Autophagy in Vertebrate Development2018

    • Author(s)
      Noboru Mizushima
    • Organizer
      Gordon Research Conference: Autophagy in Stress, Development & Disease
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 構造生物学から迫るオートファジーの分子機構2017

    • Author(s)
      野田展生
    • Organizer
      2016年度量子ビームサイエンスフェスタ
    • Place of Presentation
      つくば国際会議場(茨城県・つくば市)
    • Year and Date
      2017-03-14
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] オートファジーを標的としたパーキンソン病治療薬開発2017

    • Author(s)
      斉木臣二
    • Organizer
      日経バイオテクプロフェッショナルセミナー
    • Place of Presentation
      Learning Square新橋(東京都・港区)
    • Year and Date
      2017-03-06
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Novel Methods for Monitoring Autophagosome Maturation and Autophagic Flux2017

    • Author(s)
      Noboru Mizushima
    • Organizer
      Keystone Symposium: Autophagy Network Integration in Health and Disease
    • Place of Presentation
      Copper Mountain (USA)
    • Year and Date
      2017-02-12
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Autophagy in intracellular quality control2017

    • Author(s)
      Noboru Mizushima
    • Organizer
      Keystone Symposia on Aging and Mechanisms of Aging-Related Disease
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Physiological roles and molecular mechanisms of autophagy2017

    • Author(s)
      Noboru Mizushima
    • Organizer
      The 14th Bone Biology Forum
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Maturation of the autophagosome2017

    • Author(s)
      Noboru Mizushima
    • Organizer
      EMBO Conference "Autophagy - from molecular principles to human diseases"
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Autophagosomal closure is mediated by the ESCRT machinery2017

    • Author(s)
      Keigo Morita, Ikuko Koyama-Honda, Yoshihiro Yamashita, Toshihide Ueno, Eiji Morita, Hiroyuki Mano, Noboru Mizushima
    • Organizer
      The American Society of Cell Biology 57th Annual Meeting
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Autophagy research: recent progresses and future directions2017

    • Author(s)
      Noboru Mizushima
    • Organizer
      The 42nd Annual Meeting of the Japan Society for Investigative Dermatology
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 細胞の守護者オートファジー:疾患に対抗する細胞内自己分解システム2016

    • Author(s)
      吉森保
    • Organizer
      第68回日本皮膚科学会 西部支部学術大会
    • Place of Presentation
      米子コンベンションセンター(鳥取県・米子市)
    • Year and Date
      2016-11-19
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Autophagy and mitophagy regulation by small chemicals2016

    • Author(s)
      Shinji Saiki
    • Organizer
      The 13th Conference of Asian Society for Mitochondrial Research and Medicine
    • Place of Presentation
      TKP Garden City Shinagawa(東京都・港区)
    • Year and Date
      2016-10-30
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Autophagy: Its molecular machinery and implications in diseases.2016

    • Author(s)
      Tamotsu Yoshimori
    • Organizer
      HCV2016 “23rd International Symposium on Hepatitis C Virus and Related Viruses”
    • Place of Presentation
      Kyoto International Conference Center (京都府・京都市)
    • Year and Date
      2016-10-11
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] オートファジー調節による神経変性疾患の治療戦略2016

    • Author(s)
      斉木臣二
    • Organizer
      AMED難治性疾患実用化研究事業『筋萎縮性側索硬化症の新規治療法開発を目指した病態解明』平成28年度ワークショップ
    • Place of Presentation
      都市センターホテル(東京都・千代田区)
    • Year and Date
      2016-09-30
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Live imaging and molecular dissection of organelle degradation in the lens2016

    • Author(s)
      Noboru Mizushima
    • Organizer
      The XXII Biennial Meeting of the International Society for Eye Research
    • Place of Presentation
      京王プラザホテル(東京都・新宿区)
    • Year and Date
      2016-09-28
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] オートファジーによる核と小胞体の分解の分子基盤2016

    • Author(s)
      中戸川仁
    • Organizer
      第89回日本生化学会大会
    • Place of Presentation
      東北大学川内北キャンパス(宮城県・仙台市)
    • Year and Date
      2016-09-25
    • Related Report
      2016 Annual Research Report
  • [Presentation] The role of microglia in the pathogenesis of Parkinson’s disease2016

    • Author(s)
      斉木臣二
    • Organizer
      第41回日本微小循環学会
    • Place of Presentation
      コクヨホール(東京都・港区)
    • Year and Date
      2016-09-23
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Molecular mechanisms of autophagic degradation of the nucleus and the endoplasmic reticulum in yeast2016

    • Author(s)
      中戸川仁
    • Organizer
      14th International Congress on Yeast
    • Place of Presentation
      淡路夢舞台国際会議場(兵庫県・淡路市)
    • Year and Date
      2016-09-11
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Autophagy: Its Membrane Dynamics and Implications in Diseases2016

    • Author(s)
      Tamotsu Yoshimori
    • Organizer
      12th International Congress of Cell Biology “Exploring Cellular Structure and Function”.
    • Place of Presentation
      Prague (Czech Republic)
    • Year and Date
      2016-07-21
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] オートファジーによる細胞内分解の意義2016

    • Author(s)
      水島昇
    • Organizer
      第48回日本動脈硬化学会
    • Place of Presentation
      京王プラザホテル(東京都・新宿区)
    • Year and Date
      2016-07-14
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 細胞の守護者オートファジー:疾患に対抗する細胞内大規模分解システム2016

    • Author(s)
      吉森保
    • Organizer
      第11回トランスポーター研究会年会 第316回生存圏シンポジウム「多様性が切り拓く膜輸送研究の新時代」
    • Place of Presentation
      京都大学(京都府・京都市)
    • Year and Date
      2016-07-02
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] オートファジーによる核と小胞体の選択的分解の分子機構2016

    • Author(s)
      中戸川仁
    • Organizer
      第68回日本細胞生物学会
    • Place of Presentation
      京都テルサ(京都府・京都市)
    • Year and Date
      2016-06-15
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] The Life of the Autophagosome2016

    • Author(s)
      Noboru Mizushima
    • Organizer
      Keystone Symposia Autophagy: Molecular and Physiological Mechanisms
    • Place of Presentation
      Whistler (Canada)
    • Year and Date
      2016-06-06
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Blood biomarkers for Parkinson’s disease2016

    • Author(s)
      斉木臣二
    • Organizer
      第57回日本神経学会 Neuroscience Frontier Symposium
    • Place of Presentation
      神戸国際会議場(兵庫県・神戸市)
    • Year and Date
      2016-05-18
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Drug development for Parkinson’s disease and autophagy2016

    • Author(s)
      Shinji Saiki
    • Organizer
      The 4th Sino-Japan Symposium on Autophagy
    • Place of Presentation
      Beijing (China)
    • Year and Date
      2016-04-23
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Mammalian Autophagy: Molecular Machinery and Anti-Disease Function.2016

    • Author(s)
      Tamotsu Yoshimori
    • Organizer
      Special Seminar at Institute of Biophysics, Chinese Academy of Sciences and “The 4th Sino-Japan Symposium on Autophagy, 2016”
    • Place of Presentation
      Beijing (China)
    • Year and Date
      2016-04-22
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Mechanisms that drive nucleophagy and ER-phagy2016

    • Author(s)
      Hitoshi Nakatogawa
    • Organizer
      4th Sino-Japan Symposium on Autophagy
    • Place of Presentation
      Beijing (China)
    • Year and Date
      2016-04-22
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 20 Years of autophagy - Towards understanding the intracellular self-degradation system fighting against diseases.2016

    • Author(s)
      Tamotsu Yoshimori
    • Organizer
      The 1st Cold Spring Harbor Asia Conference on Ubiquitin Family, Autophagy and Diseases.
    • Place of Presentation
      Suzhou (China)
    • Year and Date
      2016-04-18
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Yeast cells eat the ER and nucleus to survive starvation conditions2016

    • Author(s)
      Hitoshi Nakatogawa
    • Organizer
      The 2016 Minisymposium on Autophagy
    • Place of Presentation
      Taipei (Taiwan)
    • Year and Date
      2016-04-15
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Molecular Mechanisms of ER-Phagy and Nucleophagy in Yeast2016

    • Author(s)
      中戸川仁
    • Organizer
      Gordon Research Conference
    • Place of Presentation
      Ventura, USA
    • Year and Date
      2016-03-21
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Selective Autophagy and Diseases.2016

    • Author(s)
      Tamotsu Yoshimori
    • Organizer
      Gordon Research Conference on Autophagy in Stress, Development & Disease.
    • Place of Presentation
      Ventura, USA
    • Year and Date
      2016-03-20
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] オートファジー入門2016

    • Author(s)
      野田展生
    • Organizer
      第89回日本薬理学会年会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2016-03-11
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 20 years of Autophagy: towards Understanding the Intracellular Self-Degradation System Fighting against Diseases.2016

    • Author(s)
      Tamotsu Yoshimori
    • Organizer
      2016 International A3 Foresight Symposium on Autophagy.
    • Place of Presentation
      Daejeon, Korea
    • Year and Date
      2016-02-25
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Mechanistic Insights into Membrane Dynamics in Autophagy.2016

    • Author(s)
      Tamotsu Yoshimori
    • Organizer
      FRIAS Black Forrest Winter Conference on Autophagic Membrane Trafficking and Dynamics in Ageing and Disease
    • Place of Presentation
      Freiburg, Germany.
    • Year and Date
      2016-01-29
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Autophagy: The Intracellular Self-Degradation System Fighting against Disease.2016

    • Author(s)
      Tamotsu Yoshimori
    • Organizer
      The 5th NIF Winter School on Advanced Immunology.
    • Place of Presentation
      淡路夢舞台国際会議場(兵庫県淡路市).
    • Year and Date
      2016-01-17
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Plasma Biomarkers for Parkinson’s disease.2015

    • Author(s)
      Shinji Saiki
    • Organizer
      XXI World Congress on Parkinson’s disease and related disorders.
    • Place of Presentation
      Milan, Italy
    • Year and Date
      2015-12-09
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] New Insights into Autophagy in Disease.2015

    • Author(s)
      Tamotsu Yoshimori
    • Organizer
      第38回日本分子生物学会年会・第88回日本生化学会大会合同大会
    • Place of Presentation
      神戸国際会議場(兵庫県神戸市)
    • Year and Date
      2015-12-01
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] オートファジーによる細胞内分解2015

    • Author(s)
      水島昇
    • Organizer
      第18回抗加齢歯科医学研究会
    • Place of Presentation
      東京コンファレンスセンター・品川(東京都港区)
    • Year and Date
      2015-11-29
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] オートファジーの謎に迫る2015

    • Author(s)
      水島昇
    • Organizer
      第25回日本医療薬学会年会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2015-11-21
    • Related Report
      2015 Annual Research Report
  • [Presentation] Autophagy: its molecular machinery and roles in Suppression of diseases.2015

    • Author(s)
      Tamotsu Yoshimori
    • Organizer
      Cell Biology Seminar at Hospital for Sick Children
    • Place of Presentation
      Toronto, Canada
    • Year and Date
      2015-10-28
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Autophagy: Molecular Machinery and Role in Suppression of Diseases.2015

    • Author(s)
      Tamotsu Yoshimori
    • Organizer
      The 14th CRG symposium: Cellular Machineries
    • Place of Presentation
      Barcelona, Spain
    • Year and Date
      2015-10-22
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] New Insights into Membrane Biogenesis and Targeting in Autophagy,2015

    • Author(s)
      Tamotsu Yoshimori
    • Organizer
      EMBO Conference on Autophagy: Autophagy signaling and progression in health and disease
    • Place of Presentation
      Chia, Italy
    • Year and Date
      2015-09-09
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] オートファジーその異常とがん代謝2015

    • Author(s)
      小松雅明
    • Organizer
      第39回日本鉄バイオサイエンス学会 特別講演
    • Place of Presentation
      岡山コンベンションセンター(岡山県岡山市)
    • Year and Date
      2015-08-29
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] プライマリケア医のための基礎医学講座~オートファジー研究の基礎と最新知識2015

    • Author(s)
      水島昇
    • Organizer
      第4回清水医師会学術講演会
    • Place of Presentation
      清水医師会館(静岡県静岡市)
    • Year and Date
      2015-08-07
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] オートファジーの分子機構2015

    • Author(s)
      水島昇
    • Organizer
      第45回新潟神経学夏期セミナー
    • Place of Presentation
      新潟大学(新潟県新潟市)
    • Year and Date
      2015-07-24
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Autophagy: The Intracellular Self-Degradation System Fighting against Diseases,2015

    • Author(s)
      Tamotsu Yoshimori
    • Organizer
      第21回日本遺伝子治療学会学術集会
    • Place of Presentation
      大阪国際会議場(大阪府大阪市)
    • Year and Date
      2015-07-24
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] オートファジーによる細胞内分解2015

    • Author(s)
      水島昇
    • Organizer
      札幌リウマチヤングアカデミー
    • Place of Presentation
      札幌北広島クラッセホテル(北海道北広島市)
    • Year and Date
      2015-07-18
    • Related Report
      2015 Annual Research Report
  • [Presentation] Insights into Membrane Dynamics in Autophagy,2015

    • Author(s)
      Tamotsu Yoshimori
    • Organizer
      The Gordon Research Conference on Molecular Membrane Biology.
    • Place of Presentation
      Andover, USA
    • Year and Date
      2015-07-12
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 細胞の守護者オートファジー:疾患に対抗する細胞内自己分解システム2015

    • Author(s)
      吉森保
    • Organizer
      第24回日本Cell Death学会学術集会
    • Place of Presentation
      大阪大学会館 (大阪府豊中市)
    • Year and Date
      2015-07-11
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] オートファジーによる細胞内分解2015

    • Author(s)
      水島昇
    • Organizer
      第5回大阪内分泌代謝カンファレンス
    • Place of Presentation
      銀杏会館(大阪府吹田市)
    • Year and Date
      2015-07-03
    • Related Report
      2015 Annual Research Report
  • [Presentation] Autophagy: the cellular Guardian Sustaining Life2015

    • Author(s)
      吉森保
    • Organizer
      第67回日本細胞生物学会大会
    • Place of Presentation
      タワーホール船堀 (東京都江戸川区)
    • Year and Date
      2015-06-30
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] New Insights into Membrane Dynamics and Role of Autophagy,2015

    • Author(s)
      Tamotsu Yoshimori
    • Organizer
      Keystone Symposia on Molecular and Cellular Biology “Autophagy (E6)”
    • Place of Presentation
      Breckenridge、USA
    • Year and Date
      2015-06-19
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] オートファジーの分子機構と生理的および病態生理的意義2015

    • Author(s)
      水島昇
    • Organizer
      第15回日本抗加齢医学会総会
    • Place of Presentation
      福岡国際会議場(福岡県福岡市)
    • Year and Date
      2015-05-30
    • Related Report
      2015 Annual Research Report
  • [Presentation] The Intracellular Self-Degradation System Sustaining Life,2015

    • Author(s)
      Tamotsu Yoshimori
    • Organizer
      Seminar Series at Medical Biochemistry and Biophysics.
    • Place of Presentation
      Umea, Sweden
    • Year and Date
      2015-05-26
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] オートファジー欠損マウスから見えてきたがん代謝2015

    • Author(s)
      小松雅明
    • Organizer
      日本肝臓学会 サテライト 第51回肝形態学研究会 特別講演
    • Place of Presentation
      ホテル日航熊本(熊本県熊本市)
    • Year and Date
      2015-05-19
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 細胞の守護者オートファジー:分子機構と病態生理2015

    • Author(s)
      吉森保
    • Organizer
      第118回日本小児科学会学術集会
    • Place of Presentation
      大阪国際会議場/リーガロイヤルホテル大阪 (大阪府大阪市)
    • Year and Date
      2015-04-17
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Autophagy: Its Membrane Dynamics and Role in Suppression of Diseases2015

    • Author(s)
      Tamotsu Yoshimori
    • Organizer
      British Society for Cell Biology & British Society for Developmental Biology Joint Spring Meeting.
    • Place of Presentation
      Coventry, UK.
    • Year and Date
      2015-04-12
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] オートファジーによる細胞内分解の生理意義と分子機構2015

    • Author(s)
      水島昇
    • Organizer
      第9回春風セミナー
    • Place of Presentation
      山の上ホテル(東京都千代田区)
    • Year and Date
      2015-04-09
    • Related Report
      2015 Annual Research Report
  • [Presentation] New Insights into Membrane Biogenesis and Targeting in Autophagy2015

    • Author(s)
      Yoshimori, Tamotsu
    • Organizer
      The 7th International Symposium on Autophagy
    • Place of Presentation
      Huangshan, China
    • Year and Date
      2015-03-23
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Quality control and organelle degradation in the lens2015

    • Author(s)
      Hideaki Morishita, Noboru Mizushima
    • Organizer
      The 7th International Symposium on Autophagy 2012
    • Place of Presentation
      Huangshan, China
    • Year and Date
      2015-03-19 – 2015-03-23
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Lysophagy: Damaged Lysosomes Are Selectively Eliminated by Autophagy2015

    • Author(s)
      Yoshimori, Tamotsu
    • Organizer
      Gordon Research Conference on Lysosomal Diseases
    • Place of Presentation
      Galveston, USA
    • Year and Date
      2015-03-17
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Autophagy: An intracellular degradation system2015

    • Author(s)
      Noboru Mizushima
    • Organizer
      2015 Asia ARVO
    • Place of Presentation
      Yokohama
    • Year and Date
      2015-02-19
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Autophagy: The Intracellular Self-Degradation System Fighting against Diseases2015

    • Author(s)
      Yoshimori, Tamotsu
    • Organizer
      Lorne Infection & Immunity Conference 2015
    • Place of Presentation
      Lorne, Australia
    • Year and Date
      2015-02-19
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] New Insights into Membrane Biogenesis and Targeting in Autophagy2014

    • Author(s)
      Yoshimori, Tamotsu
    • Organizer
      2014 Northeastern Asian Symposium on Autophagy
    • Place of Presentation
      Busan, Korea
    • Year and Date
      2014-12-19
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Ultrastructural analysis of autophagosome organization2014

    • Author(s)
      Noboru Mizushima
    • Organizer
      2014 Northeastern Asian Symposium on Autophagy
    • Place of Presentation
      Busan, Korea
    • Year and Date
      2014-12-18 – 2014-12-21
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] PINK1/parkin-mediated mitophagy and apoptosis2014

    • Author(s)
      Shinji Saiki
    • Organizer
      第16回北東アジアシンポジウム
    • Place of Presentation
      Busan, Korea
    • Year and Date
      2014-12-18 – 2014-12-20
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 細胞の守護者オートファジー:分子機構と疾患との関わり2014

    • Author(s)
      吉森保
    • Organizer
      脳心血管抗加齢研究会2014 併催:第4回 運動器抗加齢医学研究会/アンチエイジングフェスタ2014
    • Place of Presentation
      大阪
    • Year and Date
      2014-12-07
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Autophagy: An intracellular degradation system2014

    • Author(s)
      Noboru Mizushima
    • Organizer
      The 20th Annual Meeting of the Kyoto Cornea Club
    • Place of Presentation
      Kyoto
    • Year and Date
      2014-12-05
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 細胞の守護者オートファジー:分子機構と疾患との関わり2014

    • Author(s)
      吉森保
    • Organizer
      第41回日本臓器保存生物医学会学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2014-11-28
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] オートファジー(自食作用):その破綻とがん2014

    • Author(s)
      小松雅明
    • Organizer
      日本消化器病学会甲信越支部例会 教育講演
    • Place of Presentation
      新潟
    • Year and Date
      2014-11-22
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] パーキンソン病とオートファジー2014

    • Author(s)
      斉木臣二
    • Organizer
      第87回日本生化学会大会
    • Place of Presentation
      京都
    • Year and Date
      2014-10-15 – 2014-10-18
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 細胞の守護者オートファジー:分子機構と疾患との関わり2014

    • Author(s)
      吉森保
    • Organizer
      第3回 川島腎カンファレンス
    • Place of Presentation
      岐阜
    • Year and Date
      2014-10-11
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Insights into membrane dynamics and role of mammalian autophagy2014

    • Author(s)
      Yoshimori, Tamotsu
    • Organizer
      The 38th Naito Conference on Molecule-based biological systems
    • Place of Presentation
      Sapporo
    • Year and Date
      2014-10-09
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Molecular mechanisms of autophagy2014

    • Author(s)
      Noboru Mizushima
    • Organizer
      The 3rd International Symposium: Ptorein trafficking in helth and disease
    • Place of Presentation
      Hamburg, Germany
    • Year and Date
      2014-09-10 – 2014-09-12
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 細胞の守護者オートファジー:分子機構と疾患との関わり2014

    • Author(s)
      吉森保
    • Organizer
      第5回 Molecular Cardiovascular Conference Ⅱ
    • Place of Presentation
      神戸
    • Year and Date
      2014-09-06
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Physiological roles and molecular mechanisms of autophagy2014

    • Author(s)
      Noboru Mizushima
    • Organizer
      Nobel Dialogue Symposium
    • Place of Presentation
      Tokyo
    • Year and Date
      2014-09-04
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 細胞の守護者オートファジー:分子機構と疾患との関わり2014

    • Author(s)
      吉森保
    • Organizer
      平成26年度 がん若手研究者ワークショップ
    • Place of Presentation
      長野
    • Year and Date
      2014-09-04
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] オートファジーと疾患2014

    • Author(s)
      吉森保
    • Organizer
      第19回 日本病態プロテアーゼ学会学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2014-08-08
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 18 years of Autophagy: 生命を支える細胞内大規模分解系の理解を目指して2014

    • Author(s)
      吉森保
    • Organizer
      第10回近畿先天代謝異常症研究会
    • Place of Presentation
      大阪
    • Year and Date
      2014-07-13
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 18 years of Autophagy: towards Understanding the Intracellular Self-degradation System2014

    • Author(s)
      Yoshimori, Tamotsu
    • Organizer
      Special Seminar at College of Life Sciences
    • Place of Presentation
      Hualien, Taiwan
    • Year and Date
      2014-07-08
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 18 years of Autophagy: towards Understanding The Intracellular Self-Degradation System Sustaining Life2014

    • Author(s)
      Yoshimori, Tamotsu
    • Organizer
      2014 NIG Retreat
    • Place of Presentation
      Shizuoka
    • Year and Date
      2014-07-03
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Novel Insights into Autophagy Function2014

    • Author(s)
      Noboru Mizushima
    • Organizer
      Keystone Symposium "Autophagy: Fundamentals to Disease"
    • Place of Presentation
      Austin, USA
    • Year and Date
      2014-05-23 – 2014-05-28
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] パーキンソン病と慢性炎症2014

    • Author(s)
      斉木臣二
    • Organizer
      第55回日本神経学会総会
    • Place of Presentation
      福岡
    • Year and Date
      2014-05-21 – 2014-05-24
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] ペリー症候群の分子病態とアポトーシスの関係2014

    • Author(s)
      石川景一, 斉木臣二, 古屋徳彦, 山田大介, 今道洋子, 李元哲, 河尻澄宏, 佐々木寛典, 小池正人, 坪井義夫,服部信孝
    • Organizer
      カテコールアミンと神経疾患研究会 2014
    • Place of Presentation
      東京
    • Year and Date
      2014-04-19
    • Related Report
      2014 Annual Research Report
  • [Presentation] オートファジーの生理機能と病態との関わり2014

    • Author(s)
      水島昇
    • Organizer
      大阪大学蛋白質研究所セミナー:オートファジーと疾患
    • Place of Presentation
      大阪
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Autophagosome Biogenesis: Players and Substrates2014

    • Author(s)
      Noboru Mizushima
    • Organizer
      Gordon Research Conference on Autophagy in Stress, Development & Disease
    • Place of Presentation
      Barga, Italy
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] New insights into membrane dynamics in autophagy,2014

    • Author(s)
      Tamotsu Yoshimori
    • Organizer
      APOCB Congress and ASCB Workshops
    • Place of Presentation
      Singapore
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] オートファジーの膜の起源と選択性2014

    • Author(s)
      吉森保
    • Organizer
      大阪大学 蛋白質研究所セミナー:オートファジーと疾患
    • Place of Presentation
      大阪
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Fusion between the autophagosome and lysosome2013

    • Author(s)
      Noboru Mizushima
    • Organizer
      第86回日本生化学会大会
    • Place of Presentation
      横浜
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Organelle degradation in the lens2013

    • Author(s)
      Noboru Mizushima
    • Organizer
      The 3rd China-Japan Symposium on Autophagy
    • Place of Presentation
      Dunhuang, China
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Autophagosome formation and maturation2013

    • Author(s)
      Noboru Mizushima
    • Organizer
      Buenos Aires Conferences 2013 Autophagy: Molecular Mechanisms in Biology and Diseases
    • Place of Presentation
      Buenos Aires, Argentina
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] オートファゴソームとリソソームの融合機構2013

    • Author(s)
      水島昇
    • Organizer
      第7回オートファジー研究会
    • Place of Presentation
      掛川
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Mechanistic insights into membrane dynamics in autophagy,2013

    • Author(s)
      Tamotsu Yoshimori
    • Organizer
      The 2013 Cold Spring Harbor Asia Conference
    • Place of Presentation
      Suzhou, China
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] オートファジー:疾患に対抗する細胞内自己分解システム2013

    • Author(s)
      吉森保
    • Organizer
      第25回日本色素細胞学会学術大会
    • Place of Presentation
      大阪
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Mammalian autophagy: its machinery, membrane dynamics, and role in diseases2013

    • Author(s)
      Tamotsu Yoshimori
    • Organizer
      Argentine Society for Biochemistry and Molecular Biology scientific meeting (SAIB 2013)
    • Place of Presentation
      Buenos Aires, Argentina
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Insights into membrane dynamics in mammalian autophagy2013

    • Author(s)
      Tamotsu Yoshimori
    • Organizer
      Buenos Aires Conference 2013
    • Place of Presentation
      Buenos Aires, Argentina
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] オートファジーの膜動態制御機構2013

    • Author(s)
      吉森保
    • Organizer
      第72回日本癌学会学術総会・シンポジウムS10“がんとオートファジー”
    • Place of Presentation
      横浜
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 細胞の守護者オートファジー:分子機構、膜動態、疾患との関わり2013

    • Author(s)
      吉森保
    • Organizer
      第60回毒素シンポジウム
    • Place of Presentation
      兵庫県宍粟市
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 細胞内タンパク質分解システムの異常と病態発症2013

    • Author(s)
      小松雅明
    • Organizer
      第22回日本形成外科学会基礎学術集会
    • Place of Presentation
      新潟
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] パーキンソン病病態とオートファジーの関連について2013

    • Author(s)
      斉木臣二
    • Organizer
      細胞内ロジスティクス・シンポジウム
    • Place of Presentation
      兵庫県淡路市
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] オートファジーを標的としたパーキンソン病治療について2013

    • Author(s)
      斉木臣二
    • Organizer
      第7回オートファジー研究会
    • Place of Presentation
      静岡県掛川市
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] オートファジー

    • Author(s)
      水島昇
    • Organizer
      第23回遺伝医学セミナー
    • Place of Presentation
      千葉
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Fusion between the autophagosome and lysosome

    • Author(s)
      Noboru Mizushima
    • Organizer
      The 5th IGAKUKEN International Symposium on "Autophagy; from molecular mechanism to diseases states"
    • Place of Presentation
      東京
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] オートファジーの分子機構と生理的意義

    • Author(s)
      水島昇
    • Organizer
      第14回運動器科学研究会
    • Place of Presentation
      東京
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 哺乳類個体で見るオートファジーの意義

    • Author(s)
      水島昇
    • Organizer
      第36回日本分子生物学会年会
    • Place of Presentation
      神戸
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] オートファジーの生理的意義と分子機構

    • Author(s)
      水島昇
    • Organizer
      第28回日本糖尿病・肥満動物学会
    • Place of Presentation
      宮崎
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] New Insights into Selective Autophagy

    • Author(s)
      Tamotsu Yoshimori
    • Organizer
      The 3rd Sino-Japan Symposium on Autophagy
    • Place of Presentation
      Dunhuang, China
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Lysosome homeostasis: damaged lysosomes are selectively eliminated by autophagy

    • Author(s)
      吉森保
    • Organizer
      第86回日本生化学会大会
    • Place of Presentation
      横浜
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] New Insights into Membrane Biogenesis and Selectivity in Autophagy、

    • Author(s)
      吉森保
    • Organizer
      第5回都医学研国際シンポジウム
    • Place of Presentation
      東京
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] オートファジー:分子機構と疾患における役割

    • Author(s)
      吉森保
    • Organizer
      第8回大阪消化器フォーラム
    • Place of Presentation
      大阪
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] パーキンソン病の臨床と創薬 -オートファジーとの関連を中心に-

    • Author(s)
      斉木臣二
    • Organizer
      第33回ゲノム創薬フォーラム
    • Place of Presentation
      東京
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Book] オートファジー 分子メカニズムの理解から病態の解明まで2017

    • Author(s)
      大隅良典、吉森保、水島昇、中戸川仁
    • Total Pages
      241
    • Publisher
      南山堂
    • ISBN
      9784525134815
    • Related Report
      2017 Annual Research Report
  • [Book] メンブレントラフィック 膜・小胞による細胞内輸送ネットワーク (第1版)2016

    • Author(s)
      福田光則・吉森保 編)
    • Total Pages
      262
    • Publisher
      化学同人
    • Related Report
      2016 Annual Research Report
  • [Book] プログレッシブ 生命科学 (第一版)2014

    • Author(s)
      吉森 保、岡正啓、米田悦啓、田中亀代次、西條將文、岩井一宏、菊池章、松本真司、岡村康司、 山本浩靖、木原進士、松岡達、高木都、犬束歩、山中章弘、金井好克、磯谷綾子、伊川正人 古川貴久、戸田達史、他
    • Total Pages
      312
    • Publisher
      南山堂
    • Related Report
      2014 Annual Research Report
  • [Book] Autopahgy: Caner, Other Pathologies, Inflammation, Immunity, Infection and Aging Vol.32014

    • Author(s)
      Nobuo N. Noda, Fuyuhiko Inagaki (編集者M.A. Hayat)
    • Total Pages
      395
    • Publisher
      ELSEVIER
    • Related Report
      2013 Annual Research Report
  • [Book] Autopahgy: Caner, Other Pathologies, Inflammation, Immunity, Infection and Aging Vol.22013

    • Author(s)
      Nobuo N. Noda, Fuyuhiko Inagaki (編集者M.A. Hayat)
    • Total Pages
      398
    • Publisher
      ELSEVIER
    • Related Report
      2013 Annual Research Report
  • [Remarks] 研究室HP

    • URL

      http://square.umin.ac.jp/molbiol/

    • Related Report
      2017 Annual Research Report
  • [Remarks] 領域HP

    • URL

      http://www.proteolysis.jp/autophagy/

    • Related Report
      2017 Annual Research Report
  • [Remarks] 領域ホームページ

    • URL

      http://www.proteolysis.jp/autophagy/

    • Related Report
      2016 Annual Research Report 2015 Annual Research Report
  • [Remarks] 東京大学医学系研究科分子生物学分野ホームページ

    • URL

      http://www.cellcycle.m.u-tokyo.ac.jp/

    • Related Report
      2015 Annual Research Report
  • [Remarks] 新学術領域「オートファジー」ホームページ

    • URL

      http://www.proteolysis.jp/autophagy/

    • Related Report
      2014 Annual Research Report
  • [Remarks] オートファジーの集学的研究 分子基盤から疾患まで

    • URL

      http://www.proteolysis.jp/autophagy/

    • Related Report
      2013 Annual Research Report
  • [Patent(Industrial Property Rights)] パーキンソン病診断指標2016

    • Inventor(s)
      服部信孝、斉木臣二、波田野琢、山城一雄、石川景一、他3名
    • Industrial Property Rights Holder
      学校法人順天堂
    • Industrial Property Rights Type
      特許
    • Filing Date
      2016-02-02
    • Related Report
      2015 Annual Research Report
  • [Funded Workshop] 第8回オートファジーに関する国際会議2017

    • Related Report
      2017 Annual Research Report

URL: 

Published: 2013-07-10   Modified: 2019-07-29  

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