• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Oxygen biology: a new criterion for integrated understanding of life

Administrative Group

Project AreaOxygen biology: a new criterion for integrated understanding of life
Project/Area Number 26111001
Research Category

Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

Allocation TypeSingle-year Grants
Review Section Biological Sciences
Research InstitutionKyoto University

Principal Investigator

Mori Yasuo  京都大学, 工学研究科, 教授 (80212265)

Co-Investigator(Kenkyū-buntansha) 赤池 孝章  東北大学, 医学系研究科, 教授 (20231798)
浦野 泰照  東京大学, 大学院薬学系研究科(薬学部), 教授 (20292956)
飛田 成史  群馬大学, 大学院理工学府, 教授 (30164007)
山本 雅之  東北大学, 医学系研究科, 教授 (50166823)
中川 秀彦  名古屋市立大学, 大学院薬学研究科, 教授 (80281674)
三木 裕明  大阪大学, 微生物病研究所, 教授 (80302602)
南学 正臣  東京大学, 医学部附属病院, 教授 (90311620)
Research Collaborator INOUE masahiro  
MIURA kyoko  
SUMIMOTO hideki  
ITOH ken  
UCHIDA kouji  
SUEMATSU makoto  
SOGA tomoyoshi  
TANIGUCHI naoyuki  
Project Period (FY) 2014-07-10 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥145,860,000 (Direct Cost: ¥112,200,000、Indirect Cost: ¥33,660,000)
Fiscal Year 2018: ¥7,540,000 (Direct Cost: ¥5,800,000、Indirect Cost: ¥1,740,000)
Fiscal Year 2017: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
Fiscal Year 2016: ¥7,540,000 (Direct Cost: ¥5,800,000、Indirect Cost: ¥1,740,000)
Fiscal Year 2015: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
Fiscal Year 2014: ¥117,130,000 (Direct Cost: ¥90,100,000、Indirect Cost: ¥27,030,000)
Keywords酸素 / 活性酸素種 / 細胞シグナル / イメージング / 酸素生物学 / 低酸素 / 生体イメージング / ハイポキシア
Outline of Final Research Achievements

In order to demonstrate oxygen environment as molecular entities in living organisms, technical cores which give technique supports to area members were formed. In the area meetings, scientific achievements of area members were reported annually, and the direction of area managements, the strategy to foster young researchers, and the evaluation standard to call for area members were discussed. Many domestic and international symposia and workshops were organized along with annual meetings of different societies were held by our area. Aiming at enhancing networks among young scientists, meetings were arranged twice in collaboration with the innovative area "Dying Codes". Moreover, a special issue entitled "Oxygen Biology", to which area members contributed chapters, was arranged by our area and published in the Japanese scientific magazine "Cell".

Academic Significance and Societal Importance of the Research Achievements

当該領域は大きく変化、拡大しており、有機的に組織化しなければ、研究者間の相互連携が取りにくい分散的状況にあった。しかし、本領域の活動により、この解決に向けた大きな一歩を踏み出すことができた。また、総括班を介した本領域での異分野の世界的な統合・再構築は、日本の学術レベルと世界におけるプレゼンスの向上・強化に貢献した。本領域は基礎生物学、医科学、薬学、農学を含めた幅広い分野に関係し、臨床医学、医工学、食品・発酵化、環境科学やケミカルバイオロジーといった学際・応用分野の発展にも結び付く。さらに、共通のプラットフォームである酸素生物学に多様な世代が本領域に集結することは、人材育成に結びついた。

Report

(6 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Annual Research Report
  • 2016 Annual Research Report
  • 2015 Annual Research Report
  • 2014 Annual Research Report

Research Products

(32 results)

All 2018 2017 2016 2015 2014 Other

All Journal Article (25 results) (of which Int'l Joint Research: 8 results,  Peer Reviewed: 24 results,  Open Access: 15 results,  Acknowledgement Compliant: 17 results) Presentation (2 results) Remarks (4 results) Funded Workshop (1 results)

  • [Journal Article] 総論 新たな酸素生物学へ2018

    • Author(s)
      森泰生
    • Journal Title

      細胞(特集:酸素生物学 Oxygen Biology、森泰生 編)

      Volume: 50 Pages: 170-171

    • Related Report
      2018 Annual Research Report
  • [Journal Article] Redox regulation of electrophilic signaling by reactive persulfides in cardiac cells2017

    • Author(s)
      Nishida M, Nishimura A, Matsunaga T, Motohashi H, Kasamatsu S, Akaike T.
    • Journal Title

      Free radical biology & medicine

      Volume: 印刷中 Pages: 132-140

    • DOI

      10.1016/j.freeradbiomed.2017.01.024

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Cysteinyl-tRNA synthetase governs cysteine polysulfidation and mitochondrial bioenergetics2017

    • Author(s)
      Akaike Takaaki、、、Nishida Motohiro(4)、、、、、、Fujii Shigemoto(20)、、、Motohashi Hozumi(26)
    • Journal Title

      Nature Commun

      Volume: 8 Pages: 1-10

    • DOI

      10.1038/s41467-017-01311-y

    • NAID

      120007134656

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] A yellowish-green-light-controllable nitric oxide donor based on N-nitrosoaminophenol applicable for photocontrolled vasolidation2017

    • Author(s)
      Okuno H, Ieda N, Hotta Y, Kawaguchi M, Kimura K, Nakagawa H.
    • Journal Title

      Organic & Biomolecular Chemistry

      Volume: 15 Pages: 2791-2796

    • DOI

      10.1039/c7ob00245a

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Reactive sulfur species regulate tRNA methylthiolation and contribute to insulin secretion.2017

    • Author(s)
      Takahashi N, Wei FY, Watanabe S, Hirayama M, Ohuchi Y, Fujimura A, Kaitsuka T, Ishii I, Sawa T, Nakayama H, Akaike T, Tomizawa K.
    • Journal Title

      Nucleic Acids Research

      Volume: 45 Pages: 435-445

    • DOI

      10.1093/nar/gkw745

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Fluorescence Probe for Imaging Sirtuin Activity in Living Cells, Based on One-Step Cleavage of Dabcyl Quencher2016

    • Author(s)
      Kawaguchi M, Ikegawa S, Ieda N, Nakagawa H.
    • Journal Title

      Chembiochem

      Volume: 17 Pages: 1961-1967

    • DOI

      10.1002/cbic.201600374

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] The chemicall biology of protein hydropersulfides: Studies of a possible protective function of biological hydropersulfide generateon.2016

    • Author(s)
      Millikin R, Bianco CL, White C, Saund SS, Henriquez S, Sosa V, Akaike T, Kumagai Y, Soeda S, Toscano JP, Lin J, Fukuto JM.
    • Journal Title

      Free Radic Biol Med.

      Volume: 97 Pages: 136-147

    • DOI

      10.1016/j.freeradbiomed.2016.05.013

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Modification of tau by 8-nitro-cGMP: effects of nitric oxide-linked chemical modification on tau aggregation2016

    • Author(s)
      Yoshitake J, Soeda Y, Ida T, Sumioka A, Yoshikawa M, Matsushita K, Akaike T, Takashima A.
    • Journal Title

      Journal of Biological Chemistry

      Volume: 291 Pages: 22714-22720

    • DOI

      10.1074/jbc.m116.734350

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Drug screening and grouping by sensitivity with a panel of primary cultured cancer spheroids derived from endometrial cancer2016

    • Author(s)
      Kiyohara Y, Yoshino K, Kubota S, Okuyama H, Endo H, Ueda Y, Kimura T, Kimura T, Kamiura S, Inoue M.
    • Journal Title

      Cancer Sci

      Volume: 107 Pages: 452-460

    • DOI

      10.1111/cas.12898

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] アダクトーム解析法を用いた疾患バイオマーカーの探索2016

    • Author(s)
      柴田貴広、内田浩二
    • Journal Title

      バイオサイエンスとインダストリー

      Volume: 74 Pages: 26-29

    • NAID

      40020705853

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Redox-sensitive transient receptor potential channels in oxygen sensing and adaptation.2016

    • Author(s)
      Mori Y, Takahashi N, Polat OK, Kuroakwa T, Takeda N, Inoue M
    • Journal Title

      Pflugers Arch-Eur J Physiol

      Volume: 468 Pages: 85-97

    • DOI

      10.1007/s00424-015-1716-2

    • NAID

      120005980858

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Oxygen physiology: sensors and ion channels2016

    • Author(s)
      Mori Y, Takahashi N, Ogawa N, Gudermann T
    • Journal Title

      Pflugers Arch. Eur. J. Physiol.

      Volume: 468 Pages: 1-2

    • DOI

      10.1007/s00424-015-1762-9

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Aldehyde adducts generated during lipid peroxidation modification of proteins.2015

    • Author(s)
      Uchida K
    • Journal Title

      Free Radic Res.

      Volume: 49 Pages: 896-904

    • DOI

      10.3109/10715762.2015.1036052

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Special issue on "Recent progress in lipid peroxidation based on novel approaches2015

    • Author(s)
      Yin H, Niki E, Uchida K.
    • Journal Title

      Free Radic. Res.

      Volume: 49 Pages: 813-815

    • DOI

      10.3109/10715762.2015.1021697

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] In vivo regulation of erythropoiesis by chemically inducible dimerization of the erythropoietin receptor intracellular domain2015

    • Author(s)
      Suzuki N, Mukai HY, and Yamamoto M.
    • Journal Title

      PLoS One

      Volume: 10

    • DOI

      10.1371/journal.pone.0119442

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Hypoxia as a key player in the AKI-to-CKD transition.2014

    • Author(s)
      Tanaka S, Tanaka T, Nangaku M.
    • Journal Title

      Am J Physiol Renal Physiol

      Volume: 307

    • DOI

      10.1152/ajprenal.00425.2014

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] TRPV4 channel activity is modulated by direct interaction of the ankyrin domain to PI(4,5)P22014

    • Author(s)
      Nobuaki Takahashi, Sayaka Hamada-Nakahara, Yuzuru Itoh, Kazuhiro Takemura, Atsushi Shimada,Yoshifumi Ueda, Manabu Kitamata, Rei Matsuoka, Kyoko Hanawa-Suetsugu, Yosuke Senju, Masayuki X. Mori, Shigeki Kiyonaka, Daisuke Kohda, Akio Kitao, Yasuo Mori and Shiro Suetsugu
    • Journal Title

      Nature Communications

      Volume: 5 Pages: 4994-4994

    • DOI

      10.1038/ncomms5994

    • NAID

      130005100825

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Moderate hypoxia induces beta-cell dysfunction with HIF-1alpha independent gene expression changes2014

    • Author(s)
      Sato Y
    • Journal Title

      PLoS One

      Volume: 9

    • DOI

      10.1371/journal.pone.0114868

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] 1枚の写真館『ハダカデバネズミ』2014

    • Author(s)
      三浦恭子
    • Journal Title

      細胞工学

      Volume: 33 Pages: 1115-1115

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Membrane Protein CNNM4-Dependent Mg2+ Efflux Suppresses Tumor Progression2014

    • Author(s)
      Yosuke Funato, Daisuke Yamazaki, Shin Mizukami, Lisa Du, Kazuya Kikuchi, Hiroaki Miki
    • Journal Title

      J Clin Invest

      Volume: 124 Pages: 5398-5410

    • DOI

      10.1172/jci76614

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Reactive cysteine persulfides and S-polythiolation regulate oxidative stress and redox signaling.2014

    • Author(s)
      Ida T, Sawa T, Ihara H, Tsucr iya Y, Watanabe Y, Kumagai Y, Suematsu M, Motohashi H, Fujii S. Matsunaga T, Yamamoto M, Ono K, Devarie-Baez N O, Xian M, Fukuto J M, Akaike T.
    • Journal Title

      Proc Natl Acad Sci U S A.

      Volume: (印刷中) Pages: 1-6

    • DOI

      10.1073/pnas.1321232111

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Arachidonic acid induces direct interaction of the p67phox-Rac complex with the phagocyte oxidase Nox2, leading to superoxide production.2014

    • Author(s)
      Matono R, Miyano K, Kiyohara T, Sumimoto H.
    • Journal Title

      J. Biol. Chem.

      Volume: 289 Pages: 24874-24884

    • DOI

      10.1074/jbc.m114.581785

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Non-coding RNA derived from the region adjacent to the human HO-1 E2 enhancer selectively regulates HO-1 gene induction by modulating Pol II binding.2014

    • Author(s)
      Maruyama A, Mimura J, Itoh K.
    • Journal Title

      Nucleic Acids Res.

      Volume: 42 Pages: 13599-13614

    • DOI

      10.1093/nar/gku1169

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Lysine pyrrolation is a naturally-occurring covalent modification involved in the production of DNA mimic proteins.2014

    • Author(s)
      Miyashita H, Chikazawa M, Otaki N, Hioki Y, Shimozu Y, Nakashima F, Shibata T, Hagihara Y, Maruyama S, Matsumi N, Uchida K.
    • Journal Title

      Sci. Rep.

      Volume: 4 Pages: 5343-5343

    • DOI

      10.1038/srep05343

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A spontaneously blinking fluorophore based on intramolecular spirocyclization for live-cell super-resolution imaging2014

    • Author(s)
      Shin-nosuke Uno, Mako Kamiya, Toshitada Yoshihara, Ko Sugawara, Kohki Okabe, Mehmet C. Tarhan, Hiroyuki Fujita, Takashi Funatsu, Yasushi Okada, Seiji Tobita, Yasuteru Urano
    • Journal Title

      Nature Chem.

      Volume: 6 Pages: 681-689

    • DOI

      10.1038/nchem.2002

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] 新規クマリン型光制御HNOドナーの設計・合成と細胞応用2016

    • Author(s)
      谷卓磨, 川口充康, 家田直弥, 中川秀彦
    • Organizer
      日本薬学会第136年会
    • Place of Presentation
      パシフィコ横浜(神奈川県・横浜市)
    • Year and Date
      2016-03-25
    • Related Report
      2015 Annual Research Report
  • [Presentation] 可視光制御型HNOドナーの開発と細胞系への応用2016

    • Author(s)
      谷卓磨、川口充康、家田直弥、中川秀彦
    • Organizer
      日本酸化ストレス学会東海支部 第4回学術集会
    • Place of Presentation
      鈴鹿医療科学大学(三重県・鈴鹿市)
    • Year and Date
      2016-02-06
    • Related Report
      2015 Annual Research Report
  • [Remarks]

    • URL

      http://www.oxygenbiology.net/125071254012512.html

    • Related Report
      2017 Annual Research Report
  • [Remarks] 新学術領域研究「酸素生物学」

    • URL

      http://www.oxygenbiology.net

    • Related Report
      2016 Annual Research Report
  • [Remarks] 新学術領域研究「酸素生物学」

    • URL

      http://www.oxygenbiology.net/

    • Related Report
      2015 Annual Research Report
  • [Remarks] 新学術領域研究「酸素生物学」ホームページ

    • URL

      http://www.oxygenbiology.net/

    • Related Report
      2014 Annual Research Report
  • [Funded Workshop] An International Symposium on Oxygen Biology2015

    • Place of Presentation
      Center for Advanced Biomedical Sciences, Waseda University
    • Year and Date
      2015-07-26
    • Related Report
      2015 Annual Research Report

URL: 

Published: 2014-11-20   Modified: 2020-03-30  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi