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Creation of Glycoconjugated Meddle Molecules for Realizing Glyco-medicine

Planned Research

Project AreaMiddle molecular strategy: Creation of higher bio-functional molecules by integrated synthesis.
Project/Area Number 15H05836
Research Category

Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

Allocation TypeSingle-year Grants
Review Section Science and Engineering
Research InstitutionOsaka University

Principal Investigator

Fukase Koichi  大阪大学, 理学研究科, 教授 (80192722)

Co-Investigator(Kenkyū-buntansha) 下山 敦史  大阪大学, 理学研究科, 助教 (90625055)
真鍋 良幸  大阪大学, 理学研究科, 助教 (00632093)
Project Period (FY) 2015-06-29 – 2020-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥85,540,000 (Direct Cost: ¥65,800,000、Indirect Cost: ¥19,740,000)
Fiscal Year 2019: ¥16,640,000 (Direct Cost: ¥12,800,000、Indirect Cost: ¥3,840,000)
Fiscal Year 2018: ¥16,640,000 (Direct Cost: ¥12,800,000、Indirect Cost: ¥3,840,000)
Fiscal Year 2017: ¥16,640,000 (Direct Cost: ¥12,800,000、Indirect Cost: ¥3,840,000)
Fiscal Year 2016: ¥16,640,000 (Direct Cost: ¥12,800,000、Indirect Cost: ¥3,840,000)
Fiscal Year 2015: ¥18,980,000 (Direct Cost: ¥14,600,000、Indirect Cost: ¥4,380,000)
Keywords中分子 / 糖鎖 / 反応集積 / 複合化 / 糖鎖合成 / ワクチン / リピドA / がんワクチン / アジュバント / 免疫 / イメージング / N-グリカン / ケミカルバイオロジー / 反応集積化 / 生物機能制御
Outline of Final Research Achievements

We have synthesized many glycans and glycoconjugates. We also evaluate their biological functions. In this study, we developed a highly efficient method for the synthesis of useful glycans and glycoconjugates using integrated synthesis to achieve a quantitative supply of these compounds. Immunological function of synthesized compounds was also evaluated. In addition, we created various glycoconjugates, including cancer vaccines. These functional-integrated middle molecules have emergent functions. These compounds are expected to be the seeds of next-generation drugs. These studies were carried out in collaboration with a number of researchers.

Academic Significance and Societal Importance of the Research Achievements

糖鎖は,感染,炎症,生体防御,がんなどの重要な生命現象に関与するが,構造が複雑でかつ多くの場合不均一であるために,分子構造に基づいた生物機能解明が大きな研究課題である.また近年,糖鎖は医薬品のターゲットとして重要視されているが,合成による量的供給が困難であるため,糖鎖医薬はほとんど実現されていない.本研究で,糖鎖合成の基盤技術を発展させたことで,糖鎖合成を大きく効率化することができた.加えて,糖鎖による免疫制御を積極的に検討し,糖鎖医薬のシーズとなる化合物の創製にも成功した.これらの成果は,糖鎖科学の発展のみならず,有機合成化学から,生物学,免疫学に及ぶ幅広い分野に大きなインパクトを与えた.

Report

(6 results)
  • 2020 Final Research Report ( PDF )
  • 2019 Annual Research Report
  • 2018 Annual Research Report
  • 2017 Annual Research Report
  • 2016 Annual Research Report
  • 2015 Annual Research Report

Research Products

(331 results)

All 2021 2020 2019 2018 2017 2016 2015 Other

All Int'l Joint Research (10 results) Journal Article (63 results) (of which Int'l Joint Research: 28 results,  Peer Reviewed: 63 results,  Open Access: 22 results,  Acknowledgement Compliant: 5 results) Presentation (248 results) (of which Int'l Joint Research: 113 results,  Invited: 39 results) Book (3 results) Remarks (2 results) Patent(Industrial Property Rights) (5 results)

  • [Int'l Joint Research] The University of Naples Federico II/University of Milano-Bicocca(イタリア)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] Spanish National Research Council(スペイン)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] Academia Sinica/精華大学(中国)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] University of Napoli Federico II(イタリア)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] University of Napoli Federico II(イタリア)

    • Related Report
      2016 Annual Research Report
  • [Int'l Joint Research] Academia Sinica(台湾)

    • Related Report
      2016 Annual Research Report
  • [Int'l Joint Research] 精華大学(台湾)

    • Related Report
      2016 Annual Research Report
  • [Int'l Joint Research] University of Napoli Federico II(イタリア)

    • Related Report
      2015 Annual Research Report
  • [Int'l Joint Research] Academia Sinica(台湾)

    • Related Report
      2015 Annual Research Report
  • [Int'l Joint Research] University of Michigan(米国)

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Lipopolysaccharide from Gut‐Associated Lymphoid‐Tissue‐Resident Alcaligenes faecalis : Complete Structure Determination and Chemical Synthesis of Its Lipid?A2021

    • Author(s)
      Shimoyama A、Di Lorenzo F、Yamaura H、Mizote K、Palmigiano A、Pither MD.、Speciale I、Uto T、Masui S、Sturiale L、Garozzo D、Hosomi K、Shibata N、Kabayama K、Fujimoto Y、Silipo A、Kunisawa Jun、Kiyono H、Molinaro A、Fukase K
    • Journal Title

      Angewandte Chemie International Edition

      Volume: 60 Issue: 18 Pages: 10023-10031

    • DOI

      10.1002/anie.202012374

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] α‐Emitting cancer therapy using 211 At‐AAMT targeting LAT12021

    • Author(s)
      Kaneda‐Nakashima Kazuko、Zhang ZiJian、Manabe Yoshiyuki、Shimoyama Atsushi、Kabayama Kazuya、Watabe Tadashi、Kanai Yoshikatsu、Ooe Kazuhiro、Toyoshima Atsushi、Shirakami Yoshifumi、Yoshimura Takashi、Fukuda Mitsuhiro、Hatazawa Jun、Nakano Takashi、Fukase Koichi、Shinohara Atsushi
    • Journal Title

      Cancer Science

      Volume: 112 Issue: 3 Pages: 1132-1140

    • DOI

      10.1111/cas.14761

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Recent Advances in the Chemical Biology of N-Glycans2021

    • Author(s)
      Shirakawa Asuka、Manabe Yoshiyuki、Fukase Koichi
    • Journal Title

      Molecules

      Volume: 26 Issue: 4 Pages: 1040-1040

    • DOI

      10.3390/molecules26041040

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Behavior of glycolylated sialoglycans in the binding pockets of murine and human CD222021

    • Author(s)
      Di Carluccio Cristina、Forgione Rosa Ester、Montefiori Marco、Civera Monica、Sattin Sara、Smaldone Giovanni、Fukase K.、Manabe Y.、Crocker Paul R.、Molinaro Antonio、Marchetti Roberta、Silipo Alba
    • Journal Title

      iScience

      Volume: 24 Issue: 1 Pages: 101998-101998

    • DOI

      10.1016/j.isci.2020.101998

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Lymphoid Tissue Resident Alcaligenes Establish an Intracellular Symbiotic Environment by Creating a Unique Energy Shift in Dendritic Cells2020

    • Author(s)
      Hosomi Koji、Shibata Naoko、Shimoyama Atsushi、Uto Tomoya、Nagatake Takahiro、Tojima Yoko、Nishino Tomomi、Takeyama Haruko、Fukase Koichi、Kiyono Hiroshi、Kunisawa Jun
    • Journal Title

      Frontiers in Microbiology

      Volume: 11 Pages: 561005-561005

    • DOI

      10.3389/fmicb.2020.561005

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Chemically Synthesized Alcaligenes Lipid A Shows a Potent and Safe Nasal Vaccine Adjuvant Activity for the Induction of Streptococcus pneumoniae-Specific IgA and Th17 Mediated Protective Immunity2020

    • Author(s)
      Yoshii Ken、Hosomi Koji、Shimoyama Atsushi、Wang Yunru、Yamaura Haruki、Nagatake Takahiro、Suzuki Hidehiko、Lan Huangwenxian、Kiyono Hiroshi、Fukase Koichi、Kunisawa Jun
    • Journal Title

      Microorganisms

      Volume: 8 Issue: 8 Pages: 1102-1102

    • DOI

      10.3390/microorganisms8081102

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Adjuvant Activity of Synthetic Lipid A of Alcaligenes, a Gut-Associated Lymphoid Tissue-Resident Commensal Bacterium, to Augment Antigen-Specific IgG and Th17 Responses in Systemic Vaccine2020

    • Author(s)
      Wang Yunru、Hosomi Koji、Shimoyama Atsushi、Yoshii Ken、Yamaura Haruki、Nagatake Takahiro、Nishino Tomomi、Kiyono Hiroshi、Fukase Koichi、Kunisawa Jun
    • Journal Title

      Vaccines

      Volume: 8 Issue: 3 Pages: 395-395

    • DOI

      10.3390/vaccines8030395

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Homeostatic and pathogenic roles of GM3 ganglioside molecular species in TLR4 signaling in obesity2020

    • Author(s)
      Kanoh Hirotaka、Nitta Takahiro、Go Shinji、Inamori Kei‐ichiro、Veillon Lucas、Nihei Wataru、Fujii Mayu、Kabayama Kazuya、Shimoyama Atsushi、Fukase Koichi、Zonca Asia、Cattaneo Anna、Letizia Marilena、Ciampa Maria、Mauri Laura、Prinetti Alessandro、Sonnino Sandro、Suzuki Akemi、Inokuchi Jin‐ichi et. al.
    • Journal Title

      The EMBO Journal

      Volume: - Issue: 12 Pages: 1-20

    • DOI

      10.15252/embj.2019101732

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Synthesis of ABO blood group antigens and functional glycan display on the cell surface2020

    • Author(s)
      Tsutsui Masato、Manabe Yoshiyuki、Kabayama Kazuya、Fukase Koichi
    • Journal Title

      Arkivoc

      Volume: 2021 Issue: 4 Pages: 168-185

    • DOI

      10.24820/ark.5550190.p011.362

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Recent advances in self-adjuvanting glycoconjugate vaccines2020

    • Author(s)
      Manabe Yoshiyuki、Chang Tsung-Che、Fukase Koichi
    • Journal Title

      Drug Discovery Today: Technologies

      Volume: 2020 Pages: 1-1

    • DOI

      10.1016/j.ddtec.2020.11.006

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Concise and Reliable Syntheses of Glycodendrimers via Self-Activating Click Chemistry: A Robust Strategy for Mimicking Multivalent Glycan?Pathogen Interactions2020

    • Author(s)
      Farabi K, Manabe Y, Ichikawa H, Miyake S, Tsutsui M, Kabayama K, Yamaji T, Tanaka K, Hung S-C, Fukase K.
    • Journal Title

      J Org Chem

      Volume: 85 Issue: 24 Pages: 16014-16023

    • DOI

      10.1021/acs.joc.0c01547

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Total Syntheses of C60- and C100-Dolichols2020

    • Author(s)
      Hirao Kohtaro、Ono Risako、Manabe Yoshiyuki、Masui Seiji、Atomi Haruyuki、Fukase Koichi
    • Journal Title

      The Journal of Organic Chemistry

      Volume: 85 Issue: 17 Pages: 11549-11559

    • DOI

      10.1021/acs.joc.0c01327

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Unveiling Molecular Recognition of Sialoglycans by Human Siglec-102020

    • Author(s)
      Forgione Rosa Ester、Di Carluccio Cristina、Guzman-Caldentey Juan、Gaglione Rosa、Battista Filomena、Chiodo Fabrizio、Manabe Yoshiyuki、Arciello Angela、Del Vecchio Pompea、Fukase Koichi、Molinaro Antonio、Martin-Santamaria Sonsoles、Crocker Paul R.、Marchetti Roberta、Silipo Alba
    • Journal Title

      iScience

      Volume: 23 Issue: 6 Pages: 101231-101231

    • DOI

      10.1016/j.isci.2020.101231

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Middle Molecular and Conjugation Strategies for Development of Bioactive Middle Molecules2020

    • Author(s)
      Manabe Yoshiyuki、Shimoyama Atushi、Kabayama Kazuya、Fukase Koichi
    • Journal Title

      Journal of Synthetic Organic Chemistry, Japan

      Volume: 78 Issue: 5 Pages: 527-537

    • DOI

      10.5059/yukigoseikyokaishi.78.527

    • NAID

      130007841845

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Immunological Evaluation of Co‐Assembling a Lipidated Peptide Antigen and Lipophilic Adjuvants: Self‐Adjuvanting Anti‐Breast‐Cancer Vaccine Candidates2020

    • Author(s)
      Aiga Taku、Manabe Yoshiyuki、Ito Keita、Chang Tsung‐Che、Kabayama Kazuya、Ohshima Shino、Kametani Yoshie、Miura Ayane、Furukawa Hiroto、Inaba Hiroshi、Matsuura Kazunori、Fukase Koichi
    • Journal Title

      Angewandte Chemie International Edition

      Volume: 59 Issue: 40 Pages: 17705-17711

    • DOI

      10.1002/anie.202007999

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Chemically Synthesized TLR4 Ligands, Their Immunological Functions, and Potential as Vaccine Adjuvant2020

    • Author(s)
      Shimoyama Atsushi、Fukase Koichi
    • Journal Title

      Progress in Inflammation Research

      Volume: 87 Pages: 1-19

    • DOI

      10.1007/978-3-030-56319-6_1

    • ISBN
      9783030563189, 9783030563196
    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Development of α-Gal-Antibody Conjugates to Increase Immune Response by Recruiting Natural Antibodies2019

    • Author(s)
      Sianturi Julinton、Manabe Yoshiyuki、Li Hao-Sheng、Chiu Li-Ting、Chang Tsung-Che、Tokunaga Kento、Kabayama Kazuya、Tanemura Masahiro、Takamatsu Shinji、Miyoshi Eiji、Hung Shang-Cheng、Fukase Koichi
    • Journal Title

      Angewandte Chemie International Edition

      Volume: 58 Issue: 14 Pages: 4526-4530

    • DOI

      10.1002/anie.201812914

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Kinetically Controlled Fischer Glycosidation under Flow Conditions: A New Method for Preparing Furanosides2019

    • Author(s)
      Fukase Koichi、Masui Seiji、Manabe Yoshiyuki、Hirao Kohtaro、Shimoyama Atsushi、Fukuyama Takahide、Ryu Ilhyong
    • Journal Title

      Synlett

      Volume: 30 Issue: 04 Pages: 397-400

    • DOI

      10.1055/s-0037-1611643

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Synthesis And Immunological Evaluation of Self-adjuvanting Anticancer Vaccine Candidate.2019

    • Author(s)
      Manabe, Y., Chang, T-C., Feng, Q., Fujimoto, Y., Ohshima, S., Kametani, Y., Kabayama, K., Nimura, Y., Lin, C-C., Fukase, K.
    • Journal Title

      Peptide Science

      Volume: 2019

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Synthesis of Helicobacter pylori peptidoglycan fragments.2019

    • Author(s)
      Hu, R., Shimoyama, A., Fukase, K.
    • Journal Title

      Peptide Science

      Volume: 2019

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Single-Step Per-O-Sulfonation of Sugar Oligomers with Concomitant 1,6-Anhydro Bridge Formation for Binding Fibroblast Growth Factors2018

    • Author(s)
      Yeh Che-Jui、Ku Chiao-Chu、Lin Wei-Chen、Fan Chiao-Yuan、Zulueta Medel Manuel L.、Manabe Yoshiyuki、Fukase Koichi、Li Yaw-Kuen、Hung Shang-Cheng
    • Journal Title

      ChemBioChem

      Volume: 20 Issue: 2 Pages: 237-240

    • DOI

      10.1002/cbic.201800464

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Branched Sialylated <i>N</i>-glycans Are Accumulated in Brain Synaptosomes and Interact with Siglec-H2018

    • Author(s)
      M. Handa-Narumi, T. Yoshimura, H. Konishi, Y. Fukata, Y. Manabe, K. Tanaka, G.-m. Bao, H. Kiyama, K. Fukase, K. Ikenaka
    • Journal Title

      Cell Structure and Function

      Volume: 43 Issue: 2 Pages: 141-152

    • DOI

      10.1247/csf.18009

    • NAID

      130007439439

    • ISSN
      0386-7196, 1347-3700
    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Convergent synthesis of a bisecting GlcNAc-containing N-glycan2018

    • Author(s)
      Manabe Yoshiyuki、Shomura Hiroki、Minamoto Naoya、Nagasaki Masahiro、Takakura Yohei、Tanaka Katsunori、Silipo Alba、Molinaro Antonio、Fukase Koichi
    • Journal Title

      Chemistry - An Asian Journal

      Volume: 印刷中 Issue: 12 Pages: 1544-1551

    • DOI

      10.1002/asia.201800367

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Syntheses and Immunological Evaluation of Self-Adjuvanting Clustered N-Acetyl and N-Propionyl Sialyl-Tn Combined with a T-helper Cell Epitope as Antitumor Vaccine Candidates2018

    • Author(s)
      Chang Tsung-Che、Manabe Yoshiyuki、Fujimoto Yukari、Ohshima Shino、Kametani Yoshie、Kabayama Kazuya、Nimura Yuka、Lin Chun-Cheng、Fukase Koichi
    • Journal Title

      Angewandte Chemie International Edition

      Volume: 57 Issue: 27 Pages: 8219-8224

    • DOI

      10.1002/anie.201804437

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Narrower HOMO-LUMO gap attained by conformational switching through peripheral polyarylation in 1,4,5,8-tetraaza-9,10-anthraquinodimethanes2018

    • Author(s)
      Suzuki Takanori、Ishigaki Yusuke、Sugawara Kazuma、Umezawa Yu、Katoono Ryo、Shimoyama Atsushi、Manabe Yoshiyuki、Fukase Koichi、Fukushima Takanori
    • Journal Title

      Tetrahedron

      Volume: 74 Issue: 18 Pages: 2239-2244

    • DOI

      10.1016/j.tet.2018.03.041

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Highly Efficient Coupling of Unstable Bicyclic Pyrimidines and Pyrazoles under Basic Conditions, and its Application to the Synthesis of Pharmaceutical Compounds2018

    • Author(s)
      Goi Takashi、Fukase Koichi
    • Journal Title

      Synlett

      Volume: 29 Issue: 14 Pages: 1867-1870

    • DOI

      10.1055/s-0037-1609906

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The NLRP6 Inflammasome Recognizes Lipoteichoic Acid and Regulates Gram-Positive Pathogen Infection2018

    • Author(s)
      Hara Hideki、Seregin Sergey S.、Yang Dahai、Fukase Koichi、Chamaillard Mathias、Alnemri Emad S.、Inohara Naohiro、Chen Grace Y.、N??ez Gabriel
    • Journal Title

      Cell

      Volume: 175 Issue: 6 Pages: 1651-1664.e14

    • DOI

      10.1016/j.cell.2018.09.047

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Synthesis of Cyclopropane Fatty Acids by C(sp 3)?C(sp 3) Cross-Coupling Reaction and Formal Synthesis of α-Mycolic Acid2018

    • Author(s)
      Iwasaki Takanori、Terahigashi Shohei、Wang Yufei、Tanaka Arisa、Zhao Hanqing、Fujimoto Yukari、Fukase Koichi、Kambe Nobuaki
    • Journal Title

      Advanced Synthesis & Catalysis

      Volume: 360 Issue: 19 Pages: 3810-3817

    • DOI

      10.1002/adsc.201800901

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Introduction of 4-Chlorophenyl: A Protecting Group for the Hydroxy Function2018

    • Author(s)
      Fukase Koichi、Otsuka Yuji、Yamamoto Toshihiro
    • Journal Title

      Synlett

      Volume: 29 Issue: 11 Pages: 1510-1516

    • DOI

      10.1055/s-0036-1591984

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The second and third amino acids of Pam2 lipopeptides are key for the proliferation of cytotoxic T cells2018

    • Author(s)
      Takeda Yohei、Azuma Masahiro、Hatsugai Ryoko、Fujimoto Yukari、Hashimoto Masahito、Fukase Koichi、Matsumoto Misako、Seya Tsukasa
    • Journal Title

      Innate Immunity

      Volume: 24 Issue: 5 Pages: 323-331

    • DOI

      10.1177/1753425918777598

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Time-lapse Monitoring of TLR2 Ligand Internalization with Newly Developed Fluorescence Probes.2018

    • Author(s)
      Y. Arai, K. Yokoyama, Y. Kawahara, Q. Feng, I. Ohta, A. Shimoyama, S. Inuki, K. Fukase, K. Kabayama, Y. Fujimoto
    • Journal Title

      Org. Biomol. Chem.

      Volume: 印刷中 Issue: 20 Pages: 3824-3830

    • DOI

      10.1039/c7ob03205f

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Bradyrhizobium Lipid A: Immunological Properties and Molecular Basis of Its Binding to the Myeloid Differentiation Protein-2/Toll-Like Receptor 4 Complex2018

    • Author(s)
      Lembo-Fazio Luigi、Billod Jean-Marc、Di Lorenzo Flaviana、Paciello Ida、Pallach Mateusz、Vaz-Francisco Sara、Holgado Aurora、Beyaert Rudi、Fresno Manuel、Shimoyama Atsushi、Lanzetta Rosa、Fukase Koichi、Gully Djamel、Giraud Eric、Martin-Santamaria Sonsoles、Bernardini Maria-Lina、Silipo Alba
    • Journal Title

      Frontiers in Immunology

      Volume: 9 Pages: 1888-1888

    • DOI

      10.3389/fimmu.2018.01888

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Lymphoid tissue-resident Alcaligenes LPS induces IgA production without excessive inflammatory responses via weak TLR4 agonist activity2018

    • Author(s)
      N. Shibata, J. Kunisawa, K. Hosomi, Y. Fujimoto, K. Mizote, N. Kitayama, A. Shimoyama, H. Mimuro, S. Sato, N. 5 Kishishita, K. J. Ishii, K. Fukase, and H. Kiyono
    • Journal Title

      Mucosal Immunology

      Volume: - Issue: 3 Pages: 693-702

    • DOI

      10.1038/mi.2017.103

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Synthesis and Functional Studies of Self-Adjuvanting Cancer Vaccine Containing B Cell Epitope Derived from HER2.2017

    • Author(s)
      Feng, Q., Kabayama, K., Manabe, Y., Miyamoto, A., Kametani, Y., Fukase, K.
    • Journal Title

      Peptide Science

      Volume: 2017 Pages: 56-57

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Development of alpha1,6-fucosyltransferase inhibitors through the diversity-oriented syntheses of GDP-fucose mimics using the coupling between alkyne and sulfonyl azide.2017

    • Author(s)
      Manabe, Y., Kasahara, S., Takakura, Y., Yang, X., Takamatsu, S., Kamada Y., Miyoshi, M., Yoshidome, D., Fukasea, K.
    • Journal Title

      Bioorg. Med. Chem.

      Volume: in press Issue: 11 Pages: 2844-2850

    • DOI

      10.1016/j.bmc.2017.02.036

    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Flow Dehydration and Hydrogenation of Allylic Alcohols: Application to the Waste-Free Synthesis of Pristane2017

    • Author(s)
      Furuta, A.; Hirobe, Y.; Fukuyama, T.; Ryu, I.
    • Journal Title

      Eur. J. Org. Chem.

      Volume: 2017 Issue: 10 Pages: 1365-1368

    • DOI

      10.1002/ejoc.201700072

    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Funiculosin variants and phosphorylated derivatives promote innate immune responses via the Toll-like receptor 4/myeloid differentiation factor-2 complex2017

    • Author(s)
      Okamoto N, Mizote K, Honda H, Saeki A, Watanabe Y, Yamaguchi-Miyamoto T, Fukui R, Tanimura N, Motoi Y, Akashi-Takamura S, Kato T, Fujishita S, Kimura T, Ohto U, Shimizu T, Hirokawa T, Miyake K, Fukase K, Fujimoto Y, Nagai Y, Takatsu K
    • Journal Title

      Journal of Biological Chemistry

      Volume: 292 Issue: 37 Pages: 15378-15394

    • DOI

      10.1074/jbc.m117.791780

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] A Comprehensive Study of the Interaction between Peptidoglycan Fragments and the Extracellular Domain of Mycobacterium tuberculosis Ser/Thr Kinase PknB.2017

    • Author(s)
      Wang, Q.; Marchetti, R.; Prisic, S.; Ishii, K.; Arai, Y.; Ohta, I.; Inuki, S.; Uchiyama, S.; Silipo, A.; Molinaro, A.; Husson, R.N.; Fukase, K.; Fujimoto, Y.
    • Journal Title

      ChemBioChem

      Volume: 18 Issue: 21 Pages: 2094-2098

    • DOI

      10.1002/cbic.201700385

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Syntheses of N-aryl-protected glucosamines and their stereoselectivity in chemical glycosylations.2017

    • Author(s)
      Otsuka, Y.; Yamamoto, T.; Fukase, K.
    • Journal Title

      Tetrahedron Lett.

      Volume: 58 Issue: 31 Pages: 3019-3023

    • DOI

      10.1016/j.tetlet.2017.06.037

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Synthetic analogs of an Entamoeba histolytica glycolipid designed to combat intracellular Leishmania infection.2017

    • Author(s)
      Choy, S.L.; Bernin, H.; Aiba, T.; Bifeld, E.; Lender, S.C.; Muhlenpfordt, M.; Noll, J.; Eick, J.; Marggraff, C.; Niss, H.; Roldan, N.G.; Tanaka, S.; Kitamura, M.; Fukase, K.; Clos, J.; Tannich, E.; Fujimoto, Y.; Lotter, H.
    • Journal Title

      Sci. Rep.

      Volume: 7 Issue: 1 Pages: 1-14

    • DOI

      10.1038/s41598-017-09894-8

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Total Synthesis of Cardiolipins Containing Chiral Cyclopropane Fatty Acids.2017

    • Author(s)
      Inuki, S.; Ohta, I.; Ishibashi, S.; Takamatsu, M.; Fukase, K.; Fujimoto, Y.
    • Journal Title

      J. Org. Chem.

      Volume: 82 Issue: 15 Pages: 7832-7838

    • DOI

      10.1021/acs.joc.7b00945

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Bio-inspired Domino Reduction of Nitroarenes by Acrolein–Amine Conjugates in One-pot Operation2017

    • Author(s)
      M. Takamatsu, K. Fukase, K. Tanaka
    • Journal Title

      Chemistry Letters

      Volume: 46 Issue: 6 Pages: 811-813

    • DOI

      10.1246/cl.170175

    • NAID

      130005689313

    • ISSN
      0366-7022, 1348-0715
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Calcineurin inhibitors exacerbate coronary arteritis via the MyD88 signalling pathway in a murine model of Kawasaki disease2017

    • Author(s)
      Murata K.、Motomura Y.、Tanaka T.、Kanno S.、Yano T.、Onimaru M.、Shimoyama A.、Nishio H.、Sakai Y.、Oh-Hora M.、Hara H.、Fukase K.、Takada H.、Masuda S.、Ohga S.、Yamasaki S.、Hara T.
    • Journal Title

      Clinical & Experimental Immunology

      Volume: 190 Issue: 1 Pages: 54-67

    • DOI

      10.1111/cei.13002

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Employing BINOL-phosphoroselenoyl chloride for selective inositol phosphorylation and chemical synthesis of glycosyl inositol phospholipid from Entamoeba histolytica.2017

    • Author(s)
      Aiba, T., Suehara, S., Choy, SL., Maekawa, Y., Lotter, H., Murai, T., Inuki, S., Fukase, K., Fujimoto, Y.
    • Journal Title

      Chem. Eur. J.

      Volume: 23 Issue: 34 Pages: 8304-8308

    • DOI

      10.1002/chem.201701298

    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Product Selectivity of Esterification of L-Aspartic Acid and L-Glutamic Acid Using Chlorotrimethylsilane.2017

    • Author(s)
      Takaishi, T., Izumi, M., Ota, R., Inoue, C., Kiyota, H., Fukase, K.
    • Journal Title

      Natural Product Commun.

      Volume: 12 Pages: 247-249

    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Synthesis of Peptidoglycan Fragments from Enterococcus faecalis with Fmoc-Strategy for Glycan Elongation.2017

    • Author(s)
      Wang, N., Hasegawa, H., Huang, C. Y., Fukase, K., Fujimoto, Y.
    • Journal Title

      Chem Asian J.

      Volume: 12 Issue: 1 Pages: 27-30

    • DOI

      10.1002/asia.201601357

    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Preparation of the Pseudo Membrane Glycoprotein Using Halo Tag Technology: Novel Approach for the Functional Analysis of the Glycan on Cell Surface.2016

    • Author(s)
      Miyake, S.; Manabe, Y.; Shomura, H.; Kabayama, K.; Yamaji, T.; Hanada, K.; Fukase, K.
    • Journal Title

      Peptide Science

      Volume: 2016 Pages: 216-216

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Chemical Synthesis of a Complex-Type N-Glycan Containing a Core Fucose.2016

    • Author(s)
      Nagasaki, M.; Manabe, Y.; Minamoto, N.; Tanaka, K.; Silipo, A.; Molinaro, A.; Fukase, K.
    • Journal Title

      J. Org. Chem.

      Volume: 81 Issue: 22 Pages: 10600-10616

    • DOI

      10.1021/acs.joc.6b02106

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Development of a simple assay system for protein-stabilizing efficiency based on hemoglobin protection against denaturation and measurement of the cooperative effect of mixing protein stabilizers.2016

    • Author(s)
      Chen, S.; Manabe, Y.; Minamoto, Y.; Saiki, N.; Fukase, K.
    • Journal Title

      Bioscience, Biotechnology, and Biochemistry

      Volume: 80 Issue: 10 Pages: 1874-1878

    • DOI

      10.1080/09168451.2016.1189317

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Discovery of a Novel Scaffold as an Indoleamine 2,3-Dioxygenase 1 (IDO1) Inhibitor Based on the Pyrrolopiperazinone Alkaloid, Longamide B.2016

    • Author(s)
      Shiokawa, Z., Kashiwabara, E., Yoshidome, D., Fukase, K., Inuki, S., Fujimoto, Y.
    • Journal Title

      ChemMedChem

      Volume: 11 Issue: 24 Pages: 2682-2689

    • DOI

      10.1002/cmdc.201600446

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A Reduction-Based Sensor for Acrolein Conjugates with the Inexpensive Nitrobenzene as an Alternative to Monoclonal Antibody.2016

    • Author(s)
      Takamatsu, M., Fukase, K., Oka R., Kitazume S., Taniguchi N., Tanaka, K.
    • Journal Title

      Sci. Rep.

      Volume: 6 Issue: 1 Pages: 35872-35872

    • DOI

      10.1038/srep35872

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Isolated Polar Amino Acid Residues Modulate Lipid Binding in the Large Hydrophobic Cavity of CD1d.2016

    • Author(s)
      Inuki, S., Aiba, T., Hirata, N., Ichihara, O., Yoshidome, D., Kita, S., Maenaka, K., Fukase, K., Fujimoto, Y.
    • Journal Title

      ACS Chem. Biol.

      Volume: 11 Issue: 11 Pages: 3132-3139

    • DOI

      10.1021/acschembio.6b00674

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] One-Pot Evolution of Ageladine A through a Bio-Inspired Cascade towards Selective Modulators of Neuronal Differentiation.2016

    • Author(s)
      Iwata, T., Otsuka, S., Tsubokura, K., Kurbangalieva, A., Arai, D., Fukase, K., Nakao, Y., Tanaka, K.
    • Journal Title

      Chem. Eur. J.

      Volume: 22 Issue: 41 Pages: 14707-14716

    • DOI

      10.1002/chem.201602651

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Characterization of a Novel d-Glycero-d-talo-oct-2-ulosonic acid-substituted Lipid A Moiety in the Lipopolysaccharide Produced by the Acetic Acid Bacterium Acetobacter pasteurianus NBRC 3283.2016

    • Author(s)
      Hashimoto, M., Ozono, M., Furuyashiki, M., Baba, R., Hashiguchi, S., Suda, Y., Fukase, K., Fujimoto, Y.
    • Journal Title

      J. Biol. Chem.

      Volume: 291 Issue: 40 Pages: 21184-21194

    • DOI

      10.1074/jbc.m116.751271

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Regioselective phosphorylation of myo-inositol with BINOL-derived phosphoramidites and its application for protozoan lysophosphatidylinositol.2016

    • Author(s)
      Aiba, T., Sato, M., Umegaki, D., Iwasaki, T., Kambe, N., Fukase, K., Fujimoto, Y.
    • Journal Title

      Org. Biomol. Chem.

      Volume: 14 Issue: 28 Pages: 6672-6675

    • DOI

      10.1039/c6ob01062h

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Efficient synthesis of the disialylated tetrasaccharide motif in N-glycan via an amide protection strategy.2016

    • Author(s)
      Zhou, J.; Manabe, Y.; Tanaka, K.; Fukase, K.
    • Journal Title

      Chem. Asian. J.

      Volume: 11 Issue: 9 Pages: 1436-1440

    • DOI

      10.1002/asia.201600139

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Peptidoglycan Microarray as A Novel Tool to Explore Protein-Ligand Recognition.2016

    • Author(s)
      Wang, N.; Hirata, A.; Nokihara, K.; Fukase, K.; Fujimoto, Y.
    • Journal Title

      Biopolymers

      Volume: 未定 Issue: 4 Pages: 00-00

    • DOI

      10.1002/bip.22807

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Synthesis of characteristic Mycobacterium peptidoglycan (PGN) fragments utilizing with chemoenzymatic preparation of meso-diaminopimelic acid (DAP), and their modulation of innate immune responses.2016

    • Author(s)
      Wang, Q.; Matsuo, Y.; Pradipta, A.R.; Inohara, N.; Fujimoto, Y.; Fukase, K.
    • Journal Title

      Org. Biomol. Chem.

      Volume: 14 Issue: 3 Pages: 1013-1023

    • DOI

      10.1039/c5ob02145f

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Synthesis of the Conjugates of Tumor Antigens with Adjuvants for the Efficient Cancer Immunotherapy.2015

    • Author(s)
      Manabe, Y.; Chang, T-C.; Li, H-S.; Terao, N.; Takamatsu, S.; Tanemura, M.; Miyoshi, E.; Fukase, K.
    • Journal Title

      Peptide Science

      Volume: 2015 Pages: 77-78

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effective Synthesis of Oligosaccharide under Microfluidic Conditions2015

    • Author(s)
      Fukase, K.; Shimoyama, A.; Manabe, Y.
    • Journal Title

      Journal of Synthetic Organic Chemistry, Japan

      Volume: 73 Issue: 5 Pages: 452-459

    • DOI

      10.5059/yukigoseikyokaishi.73.452

    • NAID

      130005077685

    • ISSN
      0037-9980, 1883-6526
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Chemical Approach to a Whole Body Imaging of Sialo-N-Linked Glycans.2015

    • Author(s)
      Tanaka, K.; Fukase, K.
    • Journal Title

      Top. Curr. Chem.

      Volume: 367 Pages: 201-230

    • DOI

      10.1007/128_2014_603

    • ISBN
      9783319213163, 9783319213170
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 分子イメージングによる糖鎖複合体の動態解析2015

    • Author(s)
      深瀬浩一, 田中克典, 下山敦史
    • Journal Title

      日本分子イメージング学会機関誌JSMI report

      Volume: 8 Pages: 18-25

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 効率的α-シアリル化反応の開発と生物活性分子の創製2015

    • Author(s)
      真鍋良幸, 深瀬浩一
    • Journal Title

      化学

      Volume: 70 Pages: 66-67

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Presentation] Synthetic Biology Approach for Elucidating the N-Glycan Functions2021

    • Author(s)
      Yoshiyuki Manabe
    • Organizer
      4th A3 Young Scientist Meeting
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Siglecとの相互作用解析のためのシアル酸含有N-グリカンの合成2021

    • Author(s)
      白川明日香、真鍋良幸、出村健太、増井誠二、深瀬浩一
    • Organizer
      第101回日本化学会春季年会
    • Related Report
      2019 Annual Research Report
  • [Presentation] カゴ型ホウ素錯体によるフッ化糖を用いたグリコシル化反応の開発2021

    • Author(s)
      生長優香、笹谷祥大、真鍋良幸、角永悠一郎、小西彬仁、安田誠、深瀬浩一
    • Organizer
      第101回日本化学会春季年会
    • Related Report
      2019 Annual Research Report
  • [Presentation] ドリコールの全合成および合成プローブを用いたドリコールの機能解析2021

    • Author(s)
      小野莉紗子,平尾宏太郎,真鍋良幸,梅川雄一,村田道雄,深瀬浩一
    • Organizer
      第101回日本化学会春季年会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 共会合型セルフアジュバンティング乳がんワクチンの合成と免疫機能評価2021

    • Author(s)
      伊藤啓太,真鍋良幸,相賀拓,樺山一哉,大島志乃,亀谷美恵,古川寛人,稲葉央,松浦和則,深瀬浩一
    • Organizer
      第101回日本化学会春季年会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Synthetic study of N-glycan from hyperthermophilic archaeon Thermococcus kodakarensis2021

    • Author(s)
      K. Hirao, Y. Manabe, I. Speciale, H. Atomi, A. Molinaro, C. De, Castro. K. Fukase
    • Organizer
      第101回日本化学会春季年会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Analysis of Membrane Protein Dynamics by Glycan-galectin Interaction Using Synthetic Glycan-displaying Cells2021

    • Author(s)
      三浦彩音 ・樺山一哉 ・真鍋良幸・三宅秀斗・白川明日香・初村洋紀・山地俊之・鈴木健一・深瀬浩一
    • Organizer
      東海大学マイクロ・ナノ啓発会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Development of astatine-211 labeled gold nanoparticles for alpha nano-brachytherapy2021

    • Author(s)
      Xuhao Huang, Hiroki Kato, Yuichiro Kadonaga, Atsushi Shimoyama, Kazuya Kabayama, Daisuke Katayama, Kazuhiro Ooe, Atsushi Toyoshima, Atsushi Shinohara, Koichi Fukase
    • Organizer
      CAMPUS Asia 2021 International Symposium
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Synthesis and evaluation of astatine-211 labeled gold nanoparticles for alpha nano-brachytherapy2021

    • Author(s)
      Xuhao Huang, Hiroki Kato, Yuichiro Kadonaga, Atsushi Shimoyama, Kazuya Kabayama, Daisuke Katayama, Kazuhiro Ooe, Atsushi Toyoshima, Atsushi Shinohara, Koichi Fukase
    • Organizer
      第101回日本化学会春季年会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 共生菌Alcaligenes faecalis由来リピドAライブラリーの合成およびその免疫調節機能2021

    • Author(s)
      山浦遼生、下山敦史、溝手啓介、細見晃司、國澤純、深瀬浩一
    • Organizer
      第101回日本化学会春季年会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 核医学治療を志向したα線放出核種標識抗体の創製と機能評価2021

    • Author(s)
      山本 竜駒、樺山 一哉、兼田 加珠子、世良田 聡、仲 哲治、篠原 厚、深瀬 浩一
    • Organizer
      第101回日本化学会春季年会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Synthesis and functions of monophosphoryl Alcaligenes faecalis lipid As2021

    • Author(s)
      Davie Kenneth, Haruki Yamaura, Atsushi Shimoyama, Koichi Fukase
    • Organizer
      第101回日本化学会春季年会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Development of highly functionalized lipid A for self-adjuvanting vaccines2021

    • Author(s)
      Yusuke Yamanaka, Atsushi Shimoyama, Koichi Fukase
    • Organizer
      第101回日本化学会春季年会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 細菌特有構造に着目したコアオリゴ糖部分構造の化学合成と機能評価2021

    • Author(s)
      松田彩那,宇戸智哉,下山敦史,深瀬浩一
    • Organizer
      第101回日本化学会春季年会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Analysis of Membrane Protein Dynamics by Glycan-galectin Interaction Using Synthetic Glycan-displaying Cells2020

    • Author(s)
      Ayane Miura, Syuto Miyake, Kazuya Kabayama, Yoshiyuki Manabe, Asuka Shirakawa, Hiroki Syomura, Toshiyuki Yamaji, Kenichi Suzuki, Koichi Fukase
    • Organizer
      Academia Sinica-Osaka University Symposium 2020
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Immunological Evaluation of Conjugate/Co-Assembly of Peptide Antigen and Adjuvant as Self-adjuvanting Anti-breast Cancer Candidates2020

    • Author(s)
      Keita Ito, Yoshiyuki Manabe, Taku Aiga, Tsung-Che Chang, Kazuya Kabayama, Shino Ohshima, Yoshie Kametani, Hiroto Furukawa, Hiroshi Inaba, Kazunori Matsuura, and Koichi Fukase
    • Organizer
      第57回ペプチド討論会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Siglecとの相互作用解明を目指した重水素標識シアル酸含有N-グリカンの合成研究2020

    • Author(s)
      白川明日香、真鍋良幸、出村健太、増井誠二、深瀬浩一
    • Organizer
      第10回CSJ化学フェスタ
    • Related Report
      2019 Annual Research Report
  • [Presentation] コアフコースの機能制御を目指したFUT8阻害剤の開発2020

    • Author(s)
      柳原 茉由、高倉 陽平、真鍋 良幸、深瀬 浩一
    • Organizer
      第10回CSJ化学フェスタ
    • Related Report
      2019 Annual Research Report
  • [Presentation] コアフコース含有N-グリカンの機能解明・制御を目指したケミカルバイオロジー2020

    • Author(s)
      真鍋 良幸,Roberta Marchetti,武部 智之,笠原 里実,高倉 陽平,二瓶 渉,田中 克典,樺山 一哉, Fabrizio Chiodo,花島 慎弥,鎌田 佳宏,三善 英知, Hari Prasad Dulal,山口 芳樹,安達 禎之,大野 尚仁,田中 浩士, Alba Silipo, Antonio Molinaro,深瀬 浩一
    • Organizer
      第62回天然有機化合物討論会
    • Related Report
      2019 Annual Research Report
  • [Presentation] アジュバント-抗原複合体の創製を目指した高次機能化リピドAの開発2020

    • Author(s)
      山中優介、下山敦史 、深瀬浩一
    • Organizer
      第10回CSJ化学フェスタ
    • Related Report
      2019 Annual Research Report
  • [Presentation] Campylobacter jejuni 由来リピドAの系統的合成と機能解析2020

    • Author(s)
      藤江駿成・中川翔・松浦良史・下山敦史・深瀬浩一
    • Organizer
      第10回CSJ化学フェスタ
    • Related Report
      2019 Annual Research Report
  • [Presentation] 腸管免疫組織共生菌リピドAライブラリーの合成とTLR4-MD2受容体機能制御2020

    • Author(s)
      山浦遼生、下山敦史、溝手啓介、深瀬浩一
    • Organizer
      第10回CSJ化学フェスタ
    • Related Report
      2019 Annual Research Report
  • [Presentation] α線核種標識抗体の創製と機能評価2020

    • Author(s)
      東 茉由、樺山 一哉、角永 悠一郎、後藤 浩太朗、月村 亘、松田 昭生、水野 真盛、深瀬 浩一
    • Organizer
      第10回CSJ化学フェスタ
    • Related Report
      2019 Annual Research Report
  • [Presentation] 寄生・共生箘由来リポ多糖部分構造の化学合成と免疫調節機能の解明2020

    • Author(s)
      下山敦史、山浦遼生、宇戸智哉、細見晃司、Di Lorenzo Flaviana, 藤本ゆかり、Molinaro Antonio、清野 宏、國澤 純、深瀬浩一
    • Organizer
      第14回バイオ関連化学シンポジウム
    • Related Report
      2019 Annual Research Report
  • [Presentation] Synthesis and function study of glycoconjugate vaccine for efficient cancer2019

    • Author(s)
      Yoshiyuki Manabe
    • Organizer
      日本化学会 第99春季年会 (2019)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] ハイスループットスクリーニングによるα1,6-フコシルトランスフェラーゼ (FUT8) 阻害剤の探索と構造展開2019

    • Author(s)
      武部智之、真鍋良幸、笠原里美、Yang XiaoXiao、高松真二、三善英知、樺山一哉、深瀬浩一
    • Organizer
      第99回日本化学会年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 多分枝N-結合型糖鎖の網羅的合成を可能とする多様性指向型合成戦略の検討2019

    • Author(s)
      白川明日香、真鍋良幸、出村健太、増井誠二、深瀬浩一
    • Organizer
      第99回日本化学会年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 超好熱性アーキアのN-グリカン担体脂質ドリコールの合成研究2019

    • Author(s)
      平尾宏太郎、真鍋良幸、小野莉紗子、深瀬浩一
    • Organizer
      第99回日本化学会年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Targeted alpha therapy project using 211At in Osaka University2019

    • Author(s)
      Koichi Fukase
    • Organizer
      Interdisciplinary approach of applying cutting-edge technologies at the frontier of cancer research
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Synthesis of bio-functional molecules by middle molecular strategy2019

    • Author(s)
      深瀬浩一
    • Organizer
      第99回日本化学会年会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Systematic synthesis and function of Campylobacter jejuni lipid As2019

    • Author(s)
      Sho Nakagawa, Yoshifumi Matsura, Atsushi Shimoyama, Koichi Fukase
    • Organizer
      第99回日本化学会年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 相乗的作用により受容体機能制御を行うTLR4/MD-2リガンドの合成と機能2019

    • Author(s)
      松浦良史、下山敦史、深瀬浩一
    • Organizer
      第99回日本化学会年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 共生菌由来リポオリゴ糖の機能解析とコアオリゴ糖の合成研究2019

    • Author(s)
      宇戸智哉、溝手啓介、下山 敦史、深瀬 浩一
    • Organizer
      第99回日本化学会年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 膜貫通ペプチドを用いたインスリン受容体とガングリオシドGM3の静電的相互作用解析2019

    • Author(s)
      二村友香、樺山一哉、朝比奈雄也、花島慎弥、北條裕信、村田道雄、深瀬浩一
    • Organizer
      第99回日本化学会年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] TLR4-MD-2の内在性リガンドとしてのガングリオシドGM32019

    • Author(s)
      藤居真優、樺山一哉、下山敦史、狩野裕考、井ノ口仁一、大戸梅治、清水敏之、深瀬浩一
    • Organizer
      第99回日本化学会年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Synthesis and function of Helicobacter pylori peptidoglycan fragments2019

    • Author(s)
      Ruofang Hu, Atsushi Shimoyama, Koichi Fukase
    • Organizer
      第99回日本化学会年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Synthesis and immunological evaluation of self-adjuvanting anticancer vaccine candidate2018

    • Author(s)
      Yoshiyuki Manabe, Tsung-Che Chang, Qi Feng, Yukari Fujimoto, Shino Ohshima, Yoshie Kametani, Kazuya Kabayama, Yuka Nimura, Chun-Cheng Lin, Koichi Fukase
    • Organizer
      10th International Peptide Symposium
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Syntheses of complex type N-glycans and live cell imaging of their protein conjugates2018

    • Author(s)
      Yoshiyuki Manabe, Masahiro Nagasaki, Hiroki Shomura, Naoya Minamoto, Soichiro Okamura, Shuto Miyake, Kanae Hatano, Kazuya Kabayama and Koichi Fukase
    • Organizer
      the 14th International Kyoto Conference on New Aspects of Organic Chemistry (IKCOC-14)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Efficient syntheses of ABO blood type antigens and its immune evaluation2018

    • Author(s)
      Masato Tsutsui, Yoshiyuki Manabe, Koichi Fukase
    • Organizer
      the 14th International Kyoto Conference on New Aspects of Organic Chemistry (IKCOC-14)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Synthesis and Anti-tumor Evaluation of At-211 Labeled Amino Acid Derivative for Targeted Alpha-particle Therapy2018

    • Author(s)
      Z. Zhang, K. Kaneda, A. Toyoshima, Y. Manabe, K. Kabayama, A. Shimoyama, A. Shinohara, K. Fukase
    • Organizer
      the 14th International Kyoto Conference on New Aspects of Organic Chemistry (IKCOC-14)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Chemical syntheses of ABO blood type antigens using diacetyl strategy and investigation of their immune response2018

    • Author(s)
      The 3rd A3 Roundtable Meeting on Chemical Probe Research Hub
    • Organizer
      Masato Tsutsui, Yoshiyuki Manabe, Koichi Fukase
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Preparation of novel anticancer drugs using At-2112018

    • Author(s)
      K. Kabayama, K. Kaneda-Nakashima, Y. Manabe, A. Shimoyama, A. Toyoshima, A. Shinohara, K. Fukase
    • Organizer
      5th Asian Chemical Biology Conference (ACBC-5)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Reconstruction of glycan environments2018

    • Author(s)
      K. Fukase, Y. Manabe, K. Kabayama, H. Ichikawa, S. Miyake, H. Shomura, T. Yamaji, K. Hanada, S.-C. Hung
    • Organizer
      5th Asian Chemical Biology Conference (ACBC-5)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] SYNTHESIS OF COMPLEX TYPE N-GLYCANS2018

    • Author(s)
      Yoshiyuki Manabe, Masahiro Nagasaki, Hiroki Shomura, Naoya Minamoto, Soichiro Okamura and Koichi Fukase
    • Organizer
      29th International Carbohydrate Symposium (ICS 2018)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] N-結合型糖鎖の効率合成とそれを用いた合成生物学的研究2018

    • Author(s)
      真鍋良幸
    • Organizer
      日本化学会新領域研究グループ「有機合成化学を起点とするものづくり戦略」最終研究成果発表シンポジウム
    • Related Report
      2018 Annual Research Report
  • [Presentation] Z選択的Wittig反応を鍵とするドリコールの合成研究2018

    • Author(s)
      平尾宏太郎、真鍋良幸、小野莉紗子、深瀬浩一
    • Organizer
      第8回CSJ化学フェスタ2018
    • Related Report
      2018 Annual Research Report
  • [Presentation] N-結合型糖鎖の効率合成とその機能解明を目指したライブセルイメージング2018

    • Author(s)
      真鍋良幸、長崎政裕、初村洋紀、 源 直也、岡村壮一郎、三宅秀斗、波多野佳奈枝、樺山一哉、田中克典、深瀬浩一
    • Organizer
      第60回天然有機化合物討論会
    • Related Report
      2018 Annual Research Report
  • [Presentation] マイクロフロー系でのグリコシル化反応の開発:速度論支配のグリコシル化と不安定グリコシルドナー体の利用2018

    • Author(s)
      増井誠二、真鍋良幸、福山高英、柳 日馨、深瀬浩一
    • Organizer
      第7回 JACI/GSC シンポジウム
    • Related Report
      2018 Annual Research Report
  • [Presentation] マイクロフロー系を用いた α-gal エピトープの効率合成とがん免疫療法への適用2018

    • Author(s)
      Julinton Sianturi、真鍋良幸、樺山一哉、深瀬浩一
    • Organizer
      第7回 JACI/GSC シンポジウム
    • Related Report
      2018 Annual Research Report
  • [Presentation] Synthetic Studies of Immunostimulating Glycoconjugates: Development of New Adjuvants and Application to New Cancer Immunotherapies2018

    • Author(s)
      Koichi Fukase
    • Organizer
      3th International Symposium on Organic Reactions (ISOR-13)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Synthetic Studies of Immunostimulating Glycoconjugates toward Cancer Immunotherapies2018

    • Author(s)
      Koichi Fukase
    • Organizer
      The Ninth International Forum on Chemistry of Functional Organic Chemicals (IFOC-9)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Synthetic Studies of Glycans for Functional Analysis: Identification of Active Principle and Construction of Conjugated System2018

    • Author(s)
      Koichi Fukase
    • Organizer
      2018 Frontiers in Chemical Biology
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Synthesis and functional studies of self-adjuvanting cancer vaccine containing B cell epitope derived from HER22018

    • Author(s)
      K. Kabayama, Q. Feng, Y. Manabe, A. Miyamoto, Y. Kametani, K. Fukase
    • Organizer
      The 10th Meeting of Tokai University Micro/Nano Enlightenment (Tμne10)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Synthetic Studies of Immunostimulating Peptide-Glycan Conjugates: Development of New Adjuvants and Application to New Cancer Immunotherapies2018

    • Author(s)
      K. Fukase, Y. Manabe, K. Kabayama, T.C. Chang, F. Qi, Y. Nimura, Y. Fujimoto, Y. Kametani, S. Ohshima, A. Miyamoto, C.C. Lin
    • Organizer
      10th International Peptide Symposium
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Synthesis of Helicobacter pylori peptidoglycan fragments2018

    • Author(s)
      R. Hu, A. Shimoyama, K. Fukase
    • Organizer
      10th International Peptide Symposium
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Analysis of Electrostatic Interaction of Transmembrane Peptide of Insulin Receptor with Ganglioside GM32018

    • Author(s)
      Y. Nimura, K. Kabayama, Y. Asahina, S. Hanashima, H. Hojo, M. Murata, K. Fukase
    • Organizer
      10th International Peptide Symposium
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Synthesis and immunological function of symbiotic bacterial lipopolysaccharide partial structures.2018

    • Author(s)
      A. Shimoyama, K. Mizote, T. Uto, F. D. Lorenzo, N. Shibata, Y. Fujimoto, J. Kunisawa, H. Kiyono, A. Molinaro, K. Fukase
    • Organizer
      the 14th International Kyoto Conference on New Aspects of Organic Chemistry (IKCOC-14)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Chemical synthesis and function of Campylobacter jejuni lipid A2018

    • Author(s)
      S. Nakagawa, A. Shimoyama, K. Fukase
    • Organizer
      the 14th International Kyoto Conference on New Aspects of Organic Chemistry (IKCOC-14)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Synthesis and function of symbiotic bacterial lipopolysaccharide partial structures2018

    • Author(s)
      A. Shimoyama, K. Mizote, T. Uto, F. D. Lorenzo, N. Shibata, Y. Fujimoto, J. Kunisawa, H. Kiyono, A. Molinaro, K. Fukase
    • Organizer
      MicrobiotaMi 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Synthesis and Function of Symbiotic Bacterial Lipopolysaccharide Partial Structures, Joint Meeting of the Society for Leukocyte Biology2018

    • Author(s)
      A. Shimoyama, K. Mizote, T. Uto, N. Shibata, F. D. Lorenzo, A. Molinaro, J. Kunisawa, H. Kiyono, Y. Fujimoto, K. Fukase
    • Organizer
      (SLB) & the International Endotoxin and Innate Immunity Society(IEIIS)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Synthesis and immunological evaluation of self-adjuvanting anticancer vaccine candidates conjugated with TLR2 ligand2018

    • Author(s)
      Koichi Fukase, Tsung-che Chang, Qi Feng, Yoshiyuki Manabe, Yukari Fujimoto, Shino Ohshima, Asuka Miyamoto, Yoshie Kametani, Kazuya Kabayama
    • Organizer
      (SLB) & the International Endotoxin and Innate Immunity Society(IEIIS)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Synthesis and function of symbiotic bacterial lipopolysaccharide partial structures2018

    • Author(s)
      A. Shimoyama, K. Mizote, T. Uto, N. Shibata, F. D. Lorenzo, A. Molinaro, Y. Fujimoto, J. Kunisawa, H. Kiyono, K. Fukase
    • Organizer
      5th Asian Chemical Biology Conference (ACBC-5)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Characterization of Novel Lipooligosaccharide from Gut Symbiotic Bacteria and Chemical Synthesis of Its Active Principle Lipid A.2018

    • Author(s)
      A. Shimoyama, K. Mizote, N. Shibata, F. D. Lorenzo, Y. Fujimoto, A. Molinaro, J. Kunisawa, H. Kiyono, K. Fukase
    • Organizer
      29th International Carbohydrate Symposium (ICS 2018)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Analysis of electrostatic interaction of ganglioside GM3 with transmembrane peptide of insulin receptor.2018

    • Author(s)
      Y. Nimura, K. Kabayama, Y. Asahina, S. Hanashima, H. Hojo, M. Murata, K. Fukase
    • Organizer
      29th International Carbohydrate Symposium (ICS 2018)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Synthesis and immunological evaluation of self-adjuvanting anticancer vaccine candidates using N-modified tri sialyl-Tn antigen.2018

    • Author(s)
      K. Fukase, T.-C. Chang, Y. Manabe, Y. Fujimoto, S. Ohshima, Y. Kametani, K. Kabayama
    • Organizer
      29th International Carbohydrate Symposium (ICS 2018)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Live cell imaging analysis with BODIPY labeled lactosylceramide2018

    • Author(s)
      K. Arai, K. Kabayama, Y. Kanie, O. Kanie, K. Fukase
    • Organizer
      29th International Carbohydrate Symposium (ICS 2018)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] SYNTHESIS AND IMMUNE FUNCTION OF CAMPYLOBACTER JEJUNI LIPID A2018

    • Author(s)
      K. Arai, K. Kabayama, Y. Kanie, O. Kanie, K. Fukase
    • Organizer
      29th International Carbohydrate Symposium (ICS 2018)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Campylobacter jejuni由来リピドAの化学合成とその機能2018

    • Author(s)
      下山敦史、中川翔、深瀬浩一
    • Organizer
      第24回日本エンドトキシン・自然免疫研究会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Campylobacter jejuni由来リピドAの合成と機能2018

    • Author(s)
      中川 翔、下山敦史、深瀬浩一
    • Organizer
      第8回CSJ化学フェスタ2018
    • Related Report
      2018 Annual Research Report
  • [Presentation] 蛍光標識ラクトシルセラミトを用いたライフセルイメーシング解析2018

    • Author(s)
      新井健太・樺山一哉・蟹江善美・蟹江治・深瀬浩一
    • Organizer
      第8回CSJ化学フェスタ2018
    • Related Report
      2018 Annual Research Report
  • [Presentation] LPSと内在性糖脂質GM3による相乗的な免疫応答2018

    • Author(s)
      藤居真優、樺山一哉、下山敦史、狩野裕考、井ノ口仁一、大戸梅治、清水敏之、深瀬浩一
    • Organizer
      第12回バイオ関連シンポジウム
    • Related Report
      2018 Annual Research Report
  • [Presentation] 寄生・共生菌由来リポ多糖部分構造の合成と免疫調節機能の解明2018

    • Author(s)
      下山敦史、溝手啓介、宇戸智哉、柴田納央子、Flaviana Di Lorenzo、Antonio Molinaro、國澤純、清野宏、藤本ゆかり、深瀬浩一
    • Organizer
      第37回日本糖質学会年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Campylobacter jejuni由来リピドAの合成と機能2018

    • Author(s)
      中川翔、下山敦史、深瀬浩一
    • Organizer
      第37回日本糖質学会年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] TLR4リガンドのライブセルイメージング2018

    • Author(s)
      内藤ひかり、樺山一哉、新井 健太、下山 敦史、深瀬 浩一
    • Organizer
      日本ケミカルバイオロジー学会 第13回年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Efficient Glycosylations Using Micro Fluidic System2018

    • Author(s)
      Seiji Masui, Yoshiyuki Manabe, Kento Tokunaga, Atsushi Shimoyama, Takahide Fukuyama, Koichi Fukase.
    • Organizer
      The First International Conference on Automated Flow and Microreactor Synthesis(ICAMS-1)
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Efficient Synthesis of α-Gal Using One-Pot and Microfluidic Approaches for Development of a Novel Cancer Immunotherapy2018

    • Author(s)
      Julinton Sianturi, Yoshiyuki Manabe, Kazuya Kabayama, Koichi Fukase
    • Organizer
      The First International Conference on Automated Flow and Microreactor Synthesis(ICAMS-1)
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 膜タンパク質の合成糖鎖による修飾および生細胞における機能解析2018

    • Author(s)
      三宅秀斗、樺山一哉、初村洋紀、山地俊之、花田賢太郎、真鍋良幸、深瀬浩一
    • Organizer
      第98回日本化学年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] アルキンとスルホンアジドのカップリング反応を利用したFrgment-Based Drug Discovery2018

    • Author(s)
      高倉陽平、真鍋良幸、深瀬浩一
    • Organizer
      第98回日本化学年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 酵素反応による糖鎖伸長を鍵とするポリラクトサミン含有多分枝N-結合型糖鎖の合成2018

    • Author(s)
      岡村壮一郎,真鍋良幸,初村洋紀,Hsin-Ru Wu,Chun-Cheng Lin,深瀬浩一
    • Organizer
      第98回日本化学年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Synthesis of Biofucntional Glycans Using Integrated Reaction Systems2018

    • Author(s)
      Koichi Fukase
    • Organizer
      The First International Conference on Automated Flow and Microreactor Synthesis(ICAMS-1)
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Development of tumor vaccine candidates using self-adjuvating strategy2018

    • Author(s)
      Koichi FUKASE
    • Organizer
      9th Asian Community of Glycoscience and Glycotechnology
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 共役イミンの[4+4]型二量化反応を用いた新規アクロレイン定量法の開発2018

    • Author(s)
      土田紘也、下山敦史、樺山一哉、田中克典、深瀬浩一
    • Organizer
      第98回日本化学年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Characterization of Novel Lipooligosaccharide from Symbiotic Bacteria and Synthesis of Its Active Principle Lipid A2018

    • Author(s)
      Keisuke Mizote, Atsushi Shimoyama, Naoko Shibata, Flaviana Di Lorenzo, Yukari Fujimoto, Antonio Molinaro, Jun Kunisawa, Hiroshi Kiyono , Koichi Fukase
    • Organizer
      第98回日本化学年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] TLR4リガンドのライブセルイメージングおよびその機能評価2018

    • Author(s)
      内藤ひかり、樺山一哉、下山敦史、深瀬浩一
    • Organizer
      第98回日本化学年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Chemical synthesis and immune function of Campylobacter jejuni lipid A2018

    • Author(s)
      中川翔、下山敦史、深瀬浩一
    • Organizer
      第98回日本化学年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Efficient Synthesis of alpha-gal Epitope and Development of Novel Immunoteraphy Using the Conjugate of Anti-cancer Antibody with a-gal Epitope2017

    • Author(s)
      Julinton Sianturi, Yoshiyuki Manabe, Kento Tokunaga, Kazuya Kabayama, Koichi Fukase
    • Organizer
      日本化学会第97春季年会
    • Place of Presentation
      横浜
    • Year and Date
      2017-03-16
    • Related Report
      2016 Annual Research Report
  • [Presentation] 多様性志向型合成戦略を用いた FUT8 阻害剤の開発2017

    • Author(s)
      髙倉陽平、真鍋良幸、笠原里実,深瀬 浩一
    • Organizer
      日本化学会第97春季年会
    • Place of Presentation
      横浜
    • Year and Date
      2017-03-16
    • Related Report
      2016 Annual Research Report
  • [Presentation] 効率的α-マンノシル化を可能とする保護基パターンの探索と複合型N-グリカンの合成2017

    • Author(s)
      初村洋紀、真鍋良幸、岡村壮一郎、深瀬浩一
    • Organizer
      日本化学会第97春季年会
    • Place of Presentation
      横浜
    • Year and Date
      2017-03-16
    • Related Report
      2016 Annual Research Report
  • [Presentation] ポリラクトサミン鎖含有多分枝N-グリカンの化学酵素合成研究2017

    • Author(s)
      岡村 壮一郎、初村 洋紀、真鍋 良幸、深瀬 浩一、呉 心如、林 俊成
    • Organizer
      日本化学会第97春季年会
    • Place of Presentation
      横浜
    • Year and Date
      2017-03-16
    • Related Report
      2016 Annual Research Report
  • [Presentation] Synthesis and Immunological Evaluation of Self-Adjuvanting N-Modified Clustered Sialyl-Tn Conjugate Vaccine Candidate2017

    • Author(s)
      Tsung-che Chang, Yoshiyuki Manabe, Yukari Fujimoto, Yoshie Kametani, Kazuya Kabayama, Koichi Fukase
    • Organizer
      日本化学会第97春季年会
    • Place of Presentation
      横浜
    • Year and Date
      2017-03-16
    • Related Report
      2016 Annual Research Report
  • [Presentation] Detection of In Vivo Oxidative Stress Based on Reduction Potential of Acrolein Biomarker, FDP2017

    • Author(s)
      髙松正之、深瀬浩一、岡 律子、北爪しのぶ、谷口直之、田中克典
    • Organizer
      日本化学会第97春季年会
    • Place of Presentation
      横浜
    • Year and Date
      2017-03-16
    • Related Report
      2016 Annual Research Report
  • [Presentation] Synthesis and biological activity of glycosyl inositol phospholipid from Entamoeba histolytica2017

    • Author(s)
      Toshihiko Aiba, Sae Suehara, Hannah Bernin, Hannelore Lotter, Shinsuke Inuki, Kochi Fukase, Yukari Fujimoto
    • Organizer
      日本化学会第97春季年会
    • Place of Presentation
      横浜
    • Year and Date
      2017-03-16
    • Related Report
      2016 Annual Research Report
  • [Presentation] Toll様受容体リガンドのライブセルイメージング解析2017

    • Author(s)
      横山康平、Qi Feng、荒井洋平、井貫晋輔、藤本ゆかり、下山敦史、樺山一哉、深瀬浩一
    • Organizer
      日本化学会第97春季年会
    • Place of Presentation
      横浜
    • Year and Date
      2017-03-16
    • Related Report
      2016 Annual Research Report
  • [Presentation] Comparative study of fully synthetic self-adjuvanting cancer vaccine candidates containing tandem repeats of B cell epitope from HER22017

    • Author(s)
      FENG, Qi; KABAYAMA, Kazuya; MANABE, Yoshiyuki; KAMETANI, Yoshie; FUKASE, Koichi
    • Organizer
      日本化学会第97春季年会
    • Place of Presentation
      横浜
    • Year and Date
      2017-03-16
    • Related Report
      2016 Annual Research Report
  • [Presentation] 分子間水素結合による多量体の形成阻害を鍵としたABO式血液型糖鎖の合成研究2017

    • Author(s)
      筒井 正斗・真鍋 良幸・深瀬 浩一
    • Organizer
      日本化学会第97春季年会
    • Place of Presentation
      横浜
    • Year and Date
      2017-03-16
    • Related Report
      2016 Annual Research Report
  • [Presentation] Investigation of Concerted Modulators of TLR4/MD-22017

    • Author(s)
      Keisuke Mizote, Atsushi Shimoyama, Yoshifumi Matsuura, Mayu Fujii, Hirotaka Kanoh, Kazuya Kabayama, Jin-ichi Inokuchi, Koichi Fukase
    • Organizer
      日本化学会第97春季年会
    • Place of Presentation
      横浜
    • Year and Date
      2017-03-16
    • Related Report
      2016 Annual Research Report
  • [Presentation] 反応集積化と中分子合成:アイデアの源泉と実現2017

    • Author(s)
      深瀬浩一
    • Organizer
      第3回新学術領域研究「中分戦略」若手シンポジウム
    • Place of Presentation
      京都
    • Year and Date
      2017-03-07
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Synthesis and immunological evaluation of self-adjuvanting N-acetyl and N-propionyl clustered Sialyl-Tn conjugate as anticancer vaccine candidate2017

    • Author(s)
      Tsung-Che Chang, Yoshiyuki Manabe, Yukari Fujimoto, Shino Ohshima, Yoshie Kametani, Kazuya Kabayama, Yuka Nimura, Chun-Cheng Lin, Koichi Fukase
    • Organizer
      2nd ISBC symposium
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Chemoenzymatic synthesis of multi-antennary N-glycans containing polylactosamine2017

    • Author(s)
      Soichiro Okamura, Yoshiyuki Manabe, Hiroki Shomura, Hsin-Ru Wu, Chun-Cheng Lin, Koichi Fukase
    • Organizer
      11th International Symposium on Integrated Synthesis (ISONIS-11)&3rd International Symposium on Middle Molecular Strategy (ISMMS-3)
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Development of FUT8 inhibitors based on diversity-oriented synthesis2017

    • Author(s)
      Yohei Takakura, Yoshiyuki Manabe, Satomi Kasahara, Koichi Fukase
    • Organizer
      11th International Symposium on Integrated Synthesis (ISONIS-11)&3rd International Symposium on Middle Molecular Strategy (ISMMS-3)
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Reconstructing glycan environments using synthesized glycans2017

    • Author(s)
      Yoshiyuki Manabe, Shuto Miyake, Hiroaki Shomura, Masahiro Nagasaki, Hiroki Ichikawa, Kazuya Kabayama, Koichi Fukase
    • Organizer
      6th Gratama Workshop Groningen
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Chemical syntheses of N-glycans for their functional analysis2017

    • Author(s)
      Yoshiyuki Manabe, Koichi Fukase
    • Organizer
      Naposaka workshop
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Novel approaches for cancer immunotherapy using α-gal epitope2017

    • Author(s)
      Yoshiyuki Manabe, Hao-Sheng Li, Julinton Sianturi, Naoko Terao, Shinji Takamatsu, Masahiro Tanemura, Eiji, Miyoshi, Koichi Fukase
    • Organizer
      Eurocarb19
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Synthesis and immunological evaluation of self-adjuvanting N-modified clustered sialyl-Tn conjugate as anticancer vaccine candidate2017

    • Author(s)
      Tsung-che Chang, Yoshiyuki Manabe, Yukari Fujimoto, Yoshie Kametani, Kazuya Kabayama, Koichi Fukase
    • Organizer
      Eurocarb19
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 糖鎖機能解析に向けた細胞膜への合成糖鎖提示システムの開発2017

    • Author(s)
      三宅秀斗・真鍋良幸・初村洋紀・山地俊之・花田賢太郎・樺山一哉・深瀬浩一
    • Organizer
      第7回CSJ化学フェスタ2017
    • Related Report
      2017 Annual Research Report
  • [Presentation] 化学酵素合成法によるポリラクトサミン鎖含有多分枝N-グリカンの効率的合成研究2017

    • Author(s)
      岡村壮一郎,真鍋良幸,初村洋紀,Hsin-Ru Wu,Chun-Cheng Lin,深瀬浩一
    • Organizer
      第7回CSJ化学フェスタ2017
    • Related Report
      2017 Annual Research Report
  • [Presentation] FUT8 阻害剤の多様性指向型合成2017

    • Author(s)
      髙倉陽平・真鍋良幸・笠原里実・深瀬浩一
    • Organizer
      第7回CSJ化学フェスタ2017
    • Related Report
      2017 Annual Research Report
  • [Presentation] 分子間水素結合の形成阻害に着目したABO式血液型糖鎖の合成2017

    • Author(s)
      筒井正斗,真鍋良幸,深瀬浩一
    • Organizer
      第34回有機合成化学セミナー
    • Related Report
      2017 Annual Research Report
  • [Presentation] 多様性指向型合成戦略による FUT8 阻害剤の創製2017

    • Author(s)
      髙倉陽平・真鍋良幸・笠原里実・深瀬浩一
    • Organizer
      第11回 バイオ関連化学シンポジウム
    • Related Report
      2017 Annual Research Report
  • [Presentation] 糖鎖機能解析を目指した生細胞表面への合成糖鎖修飾法の開発2017

    • Author(s)
      三宅秀斗、真鍋良幸、初村洋紀、山地俊之、花田賢太郎、樺山一哉、深瀬浩一
    • Organizer
      第九回光塾
    • Related Report
      2017 Annual Research Report
  • [Presentation] Development of quantitative detection method for acrolein based on [4+4]cycloaddition reaction of conjugated imine2017

    • Author(s)
      Hiroya Tsuchida, Atsushi Shimoyama, Kazuya Kabayama, Katsunori Tanaka, Koichi Fukase
    • Organizer
      2nd ISBC symposium
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Development of tumor vaccine candidates using self-adjuvanting strategy2017

    • Author(s)
      Koichi Fukase
    • Organizer
      JSPS A3 Foresight Program: Asian Chemical Probe Research Hub Symposium
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Isolation and Structural Elucidation of Novel Lipooligosaccharide from Symbiotic Bacteria, and Synthesis of Its Active Principle Lipid A2017

    • Author(s)
      Atsushi Shimoyama, Keisuke Mizote, Naoko Shibata, Flaviana Di Lorenzo, Yukari Fujimoto, Antonio Molinaro, Jun Kunisawa, Hiroshi Kiyono, Koichi Fukase
    • Organizer
      11th International Symposium on Integrated Synthesis (ISONIS-11)&3rd International Symposium on Middle Molecular Strategy (ISMMS-3)
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Chemical synthesis of C. jejuni lipid A for the elucidation of its immune functionsv2017

    • Author(s)
      Sho Nakagawa, Atsushi Shimoyama, Koichi Fukase
    • Organizer
      11th International Symposium on Integrated Synthesis (ISONIS-11)&3rd International Symposium on Middle Molecular Strategy (ISMMS-3)
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Spatial-temporal analysis by BODIPY-labeled lactose ceramide2017

    • Author(s)
      Kenta ARAI, Yoshimi KANIE, Osamu KANIE, Kazuya KABAYAMA, and Koichi FUKASE
    • Organizer
      Bilateral Symposium Genomics Research Center, Academia Sinica & School of Science, Osaka University
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Chemical synthesis of immunologically relevant prokaryotic and eukaryotic glycoconjugates2017

    • Author(s)
      Koichi Fukase
    • Organizer
      International Seminar on Chemistry (ISC-2017)
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Live cell imaging analysis of floating cells using ultra-thin polymer film2017

    • Author(s)
      Kanae HATANO, Kazuya KABAYAMA, Yosuke OKAMURA, Koichi FUKASE
    • Organizer
      MNTC International Symposium 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Behavior analysis of cell membrane lipid using BODIPY-labeled lactosyl ceramide2017

    • Author(s)
      Kenta ARAI, Yoshimi KANIE, Osamu KANIE, Kazuya KABAYAMA, and Koichi FUKASE
    • Organizer
      Kanae HATANO, Kazuya KABAYAMA, Yosuke OKAMURA, Koichi FUKASE
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Challenges in Cancer Vaccine Development by Regulating Immune Responses2017

    • Author(s)
      Koichi Fukase
    • Organizer
      TOLLerant Workshop: Glycoscience at the interface between Chemistry and Biology
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Synthesis and Function of Bacterial Glycoconjugates for Regulation of Immune System2017

    • Author(s)
      A. Shimoyama, K. Fukase
    • Organizer
      TOLLerant Workshop: Glycoscience at the interface between Chemistry and Biology
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Investigation of Parasitic Bacterial and Endogenous TLR4/MD-2 Modulators2017

    • Author(s)
      A. Shimoyama, K. Mizote, Y. Matsuura, M. Fujii, H. Kanoh, K. Kabayama, J. Inokuchi, K. Fukase
    • Organizer
      Naposaka workshop
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Functional studies of Novel Lipooligosaccharide from Alcaligenes faecalis and Synthesis of Its Active Principle Lipid A2017

    • Author(s)
      Keisuke Mizote, Atsushi Shimoyama, Naoko Shibata, Flaviana Di Lorenzo, Yukari Fujimoto, Antonio Molinaro, Jun Kunisawa, Hiroshi Kiyono, Koichi Fukase
    • Organizer
      Naposaka workshop
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Concerted Mechanism of TLR4/MD-2 Modulators2017

    • Author(s)
      A. Shimoyama, K. Mizote, Y. Matsuura, M. Fujii, H. Kanoh, K. Kabayama, J. Inokuchi, K. Fukase
    • Organizer
      Eurocarb19
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Characterization of LPS/lipid A from Symbiotic Bacteria2017

    • Author(s)
      Keisuke Mizote, Atsushi Shimoyama, Naoko Shibata, Flaviana Di Lorenzo, Yukari Fujimoto, Antonio Molinaro, Jun Kunisawa, Hiroshi Kiyono, Koichi Fukase
    • Organizer
      Eurocarb19
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Chemical synthesis of immunologically relevant prokaryotic and eukaryotic glycoconjugates2017

    • Author(s)
      Koichi Fukase
    • Organizer
      “Molecular Aspects Of Host/Microbe dialogue” Joint workshop MSCA-ETN networks TOLLerant and IMMUNOSHAPE
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 共役イミンの[4+4]型二量化反応を用いた新規アクロレイン検出法の開発2017

    • Author(s)
      土田紘也、下山敦史、田中克典、深瀬浩一
    • Organizer
      第7回CSJ化学フェスタ2017
    • Related Report
      2017 Annual Research Report
  • [Presentation] 共生菌由来リポオリゴ糖の単離・構造決定及びそのリピドAの合成と機能2017

    • Author(s)
      溝手啓介、下山敦史、柴田納央子、Flaviana Di Lorenzoc、藤本ゆかり、Antonio Molinaro、國澤純、清野宏、深瀬浩一
    • Organizer
      第59回天然有機化合物討論会
    • Related Report
      2017 Annual Research Report
  • [Presentation] ガングリオシドGM3はTLR4-MD-2の多量体形成に関与する2017

    • Author(s)
      藤居真優、樺山一哉、下山敦史、狩野裕考、井ノ口仁一、大戸梅治、清水敏之、深瀬浩一
    • Organizer
      第36回日本糖質学会年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 有機合成を基盤とした糖鎖の機能解析と免疫調節への応用2017

    • Author(s)
      深瀬浩一
    • Organizer
      住友化学株式会社 健康・農業関連事業研究所講演会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] LacCerBODIPYを用いた細胞膜動態の解析2017

    • Author(s)
      新井健太、蟹江治、樺山一哉、深瀬浩一
    • Organizer
      第18回関西グライコサイエンスフォーラム
    • Related Report
      2017 Annual Research Report
  • [Presentation] Chemical syntheses of N-glycans2017

    • Author(s)
      Yoshiyuki Manabe, Koichi Fukase
    • Organizer
      Academia Sinica & Osaka University Bilateral Workshop
    • Place of Presentation
      Taipei, Taiwan
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Development of the Novel Cancer Immunotherapy Utilizing & alpha-Gal2017

    • Author(s)
      Yoshiyuki Manabe, Koichi Fukase
    • Organizer
      第7回 日中若手化学者フォーラム 7th CCS-CSJ Joint Forum on Frontier in Organic Synthesis toward Middle Molecular Strategy
    • Place of Presentation
      横浜
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Development of new immunotherapy using the conjugates of anti-cancer antibody with alpha-gal epitope2017

    • Author(s)
      Julinton Sianturi, Yoshiyuki Manabe, Kazuya Kabayama, Koichi Fukase
    • Organizer
      Workshop for Glycoscience: Biological Function of Glycans and Lipids
    • Place of Presentation
      豊中
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] マイクロフロー系を利用した糖鎖合成2017

    • Author(s)
      真鍋良幸,深瀬浩一
    • Organizer
      コンソーシアム講演会「マイクロフロー合成システムの新展開(糖鎖合成、光触媒、電場と磁場)」
    • Place of Presentation
      京都
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Synthetic study of immunoadjuvants & adjuvant-antigen conjugates toward cancer vaccines2017

    • Author(s)
      Koichi Fukase
    • Organizer
      Academia Sinica & Osaka University Bilateral Workshop
    • Place of Presentation
      Taipei, Taiwan
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 合成糖鎖を用いて免疫応答を調節する2017

    • Author(s)
      深瀬浩一
    • Organizer
      FIBER未来大学 第2回研究成果報告会
    • Place of Presentation
      神戸
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 自己と非自己の認識に関わる糖鎖と複合糖質の機能解析と免疫調節への利用2016

    • Author(s)
      深瀬浩一
    • Organizer
      第22 回日本エンドトキシン・自然免疫研究会
    • Place of Presentation
      鹿児島
    • Year and Date
      2016-12-02
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 協奏的に作用するTLR4/MD-2制御因子の機能~免疫調節作用を有する寄生菌由来LPS部分構造を中心に~2016

    • Author(s)
      下山敦史、溝手啓介、松浦良史、藤居真優、狩野裕考、樺山一哉、藤本ゆかり、井ノ口仁一、深瀬 浩一
    • Organizer
      第22 回日本エンドトキシン・自然免疫研究会
    • Place of Presentation
      鹿児島
    • Year and Date
      2016-12-02
    • Related Report
      2016 Annual Research Report
  • [Presentation] Novel tumor immunotherapy using alpha-gal antibody conjugates2016

    • Author(s)
      Julinton Sianturi, Yoshiyuki Manabe, Kento Tokunaga, Hao-Sheng Li, Kazuya Kabayama, Koichi Fukase
    • Organizer
      4th Asian Chemical Biology Conference (ACBC4)
    • Place of Presentation
      Kaohsiung, Taiwan
    • Year and Date
      2016-11-28
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Synthetic Study of Immunoconjugates for Cancer Immunotherapy2016

    • Author(s)
      Koichi Fukase
    • Organizer
      4th Asian Chemical Biology Conference (ACBC4)
    • Place of Presentation
      Kaohsiung,Taiwan
    • Year and Date
      2016-11-28
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Development of the quantitative method for acrolein detection based on [4+4] cycloaddition reaction of conjugated imine2016

    • Author(s)
      A. Shimoyama, H. Tsuchida, K. Tanaka, K. Fukase
    • Organizer
      4th Asian Chemical Biology Conference (ACBC4)
    • Place of Presentation
      Kaohsiung,Taiwan
    • Year and Date
      2016-11-28
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Concerted Mechanism of TLR4/MD-2 Modulators2016

    • Author(s)
      Keisuke Mizote, Atsushi Shimoyama, Yoshifumi Matsuura, Mayu Fujii, Kazuya Kabayama, Jin-ichi Inokuchi, Koichi Fukase
    • Organizer
      4th Asian Chemical Biology Conference (ACBC4)
    • Place of Presentation
      Kaohsiung,Taiwan
    • Year and Date
      2016-11-28
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Synthesis of Glycodendrimers as the Inhibitors of Pathogen's Infection2016

    • Author(s)
      Shuto Miyake, Yoshiyuki Manabe, Hiroaki Ichikawa, Kazuya Kabayama, Toshiyuki Yamaji, Kentaro Hanada, Koichi Fukase
    • Organizer
      The 10th International Symposium on Integrated Synthesis (ISONIS-10)
    • Place of Presentation
      淡路
    • Year and Date
      2016-11-18
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Synthesis of N-glycans containing bisecting GlcNAc or polylactosamine2016

    • Author(s)
      初村洋紀、岡村壮一郎、真鍋良幸、源直也、長崎政裕、深瀬浩一
    • Organizer
      The 10th International Symposium on Integrated Synthesis (ISONIS-10)
    • Place of Presentation
      淡路
    • Year and Date
      2016-11-18
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Development of novel tumor immunoteraphy using the conjugate of antibody with alpha-gal epitope2016

    • Author(s)
      Julinton Sianturi, Yoshiyuki Manabe, Kazuya Kabayama, Koichi Fukase
    • Organizer
      The 10th International Symposium on Integrated Synthesis (ISONIS-10)
    • Place of Presentation
      淡路
    • Year and Date
      2016-11-18
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Synthesis of Self-Adjuvanting N-modified TriSTn Antigens as Anticancer Vaccine and Evaluation of Immunogenicity2016

    • Author(s)
      Tsung-che Chang, Yoshiyuki Manabe, Yukari Fujimoto, Yoshie Kametani, Kazuya Kabayama, Koichi Fukase
    • Organizer
      The 10th International Symposium on Integrated Synthesis (ISONIS-10)
    • Place of Presentation
      Awaji
    • Year and Date
      2016-11-18
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Development of quantitative detection method of acrolein based on [4+4] cycloaddition reaction of conjugated imine2016

    • Author(s)
      Hiroya Tsuchida, Atsushi Shimoyama, Katsunori, Tanaka, Koichi Fukase
    • Organizer
      The 10th International Symposium on Integrated Synthesis (ISONIS-10)
    • Place of Presentation
      Awaji
    • Year and Date
      2016-11-18
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Synthesis of phosphatidylinositol for the elucidation of endogenous CD1d ligand2016

    • Author(s)
      中川翔、下山敦史、相羽俊彦、藤本ゆかり、深瀬浩一
    • Organizer
      The 10th International Symposium on Integrated Synthesis (ISONIS-10)
    • Place of Presentation
      Awaji
    • Year and Date
      2016-11-18
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Functional analysis of glycolipid and glycoprotein using synthetic glycans2016

    • Author(s)
      Kazuya Kabayama, Shuto Miyake, Yoshiyuki Manabe, Hiroki Shomura, Toshiyuki Yamaji, Kentaro Hanada, Koichi Fukase
    • Organizer
      Sialoglyco 2016
    • Place of Presentation
      Santa Barbara, USA
    • Year and Date
      2016-11-14
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] FUT8阻害剤の細胞における機能評価2016

    • Author(s)
      武部智之・真鍋良幸・笠原里美・Yang Xiaoxiao・樺山一哉・深瀬浩一
    • Organizer
      第6回CSJ化学フェスタ2016
    • Place of Presentation
      船堀
    • Year and Date
      2016-11-14
    • Related Report
      2016 Annual Research Report
  • [Presentation] Efficient Synthesis of a-gal Epitope and Development of Novel Immunoteraphy Using the Conjugate of Anti-cancer Antibody with alpha-gal Epitope2016

    • Author(s)
      Julinton Sianturi, Yoshiyuki Manabe, Kazuya Kabayama, Koichi Fukase
    • Organizer
      第6回CSJ化学フェスタ2016
    • Place of Presentation
      船堀
    • Year and Date
      2016-11-14
    • Related Report
      2016 Annual Research Report
  • [Presentation] Toll様受容体リガンドのライブセルイメージング解析2016

    • Author(s)
      横山康平、Qi Feng、荒井洋平、井貫晋輔、藤本ゆかり、樺山一哉、深瀬浩一
    • Organizer
      第6回CSJ化学フェスタ2016
    • Place of Presentation
      船堀
    • Year and Date
      2016-11-14
    • Related Report
      2016 Annual Research Report
  • [Presentation] 溝手啓介、下山敦史、松浦良史、藤居真優、井ノ口仁一、樺山一哉、深瀬浩一2016

    • Author(s)
      協奏的に作用するTLR4/MD-2制御因子の機能
    • Organizer
      第6回CSJ化学フェスタ2016
    • Place of Presentation
      船堀
    • Year and Date
      2016-11-14
    • Related Report
      2016 Annual Research Report
  • [Presentation] Preparation of the Pseudo Membrane Glycoprotein Using HaloTag Technology: Novel Approach for the Functional Analysis of the Glycan on Cel Surface.2016

    • Author(s)
      Shuto Miyake, Yoshiyuki Manabe, Hiroki Shomura, Kazuya Kabayama, Toshiyuki Yamaji, Kentaro Hanada, Koichi Fukase
    • Organizer
      第53回ペプチド討論会
    • Place of Presentation
      京都
    • Year and Date
      2016-10-26
    • Related Report
      2016 Annual Research Report
  • [Presentation] Synthesis of Clustered TriSTn Antigens as Anticancer Vaccine via Self-Adjuvanting Strategy and Evaluation of Immunogenicity2016

    • Author(s)
      Tsung-che Chang, Yoshiyuki Manabe, Yukari Fujimoto, Yoshie Kametani, Kazuya Kabayama, Koichi Fukase
    • Organizer
      8th Asian Community of Glycoscience and Glycotechology (ACGG) Annual Conference
    • Place of Presentation
      Wuxi, Chaina
    • Year and Date
      2016-10-13
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Syntheses and biological activities of immunomodulating glycoconjugates2016

    • Author(s)
      Koichi Fukase
    • Organizer
      Bilateral Symposium of Genomics Research Center, Academia Sinica and Graduate School of Science, Osaka University
    • Place of Presentation
      Toyonaka
    • Year and Date
      2016-10-05
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Synthesis and biological activity of Mycobacterium peptidoglycan fragments2016

    • Author(s)
      Koichi Fukase
    • Organizer
      14th Biennial Meeting International Endotoxin and Innate Immunity Society (14th IEIIS)
    • Place of Presentation
      Hamburg, Germany
    • Year and Date
      2016-09-22
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Synthesis and bio-functional studies of phosphatidylinositol for the elucidation of NKT cell pre-activation mechanism2016

    • Author(s)
      A. Shimoyama, S. Nakagawa, T. Aiba, Y. Fujimoto, K. Fukase
    • Organizer
      14th Biennial Meeting International Endotoxin and Innate Immunity Society (14th IEIIS)
    • Place of Presentation
      Hamburg, Germany
    • Year and Date
      2016-09-22
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Synthesis and Immunostimuratory Activity of Inositol Phospholipid as NKT Cell Modulator2016

    • Author(s)
      Toshihiko Aiba, Sae Suehara, Hannah Bernin, Hanna Lotter, Shinsuke Inuki, Koichi Fukase, Yukari Fujimoto
    • Organizer
      14th Biennial Meeting International Endotoxin and Innate Immunity Society (14th IEIIS)
    • Place of Presentation
      Hamburg, Germany
    • Year and Date
      2016-09-22
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Synthesis Study of Clustered Type of Mucin-Related N-modified STn Antigen as Anticancer Vaccine Candidate via Fully Synthetic Self-Adjuvanting Strategy2016

    • Author(s)
      Tsung-che Chang, Yoshiyuki Manabe, Yukari Fujimoto, Koichi Fukase
    • Organizer
      14th Biennial Meeting International Endotoxin and Innate Immunity Society (14th IEIIS)
    • Place of Presentation
      Hamburg, Germany
    • Year and Date
      2016-09-22
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Reaction-based sensor for oxidative stress markers2016

    • Author(s)
      Masayuki Takamatsu, Koichi Fukase, Ritsuko Oka, Shinobu Kitazume, Naoyuki Taniguchi, Katsunori Tanaka
    • Organizer
      3rd RIKEN-KFU workshop: From international joint chemistry laboratory to new stage of interdisciplinary research
    • Place of Presentation
      Kazan, Russia
    • Year and Date
      2016-09-21
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] alpha-galエピトープを利用した効果的がん免疫療法の開発2016

    • Author(s)
      真鍋良幸,李昊晟,徳永健斗,Julinton Sianturi,寺尾尚子,高松真二,種村匡 弘,三善英知,深瀬浩一
    • Organizer
      第58回天然有機化合物討論会
    • Place of Presentation
      仙台
    • Year and Date
      2016-09-14
    • Related Report
      2016 Annual Research Report
  • [Presentation] ライブセルイメージングによる蛍光標識抗体の動態解析2016

    • Author(s)
      波多野佳奈枝・樺山一哉・真鍋良幸・岡村陽介・深瀬浩一
    • Organizer
      バイオ関連化学シンポジウム学会
    • Place of Presentation
      金沢
    • Year and Date
      2016-09-07
    • Related Report
      2016 Annual Research Report
  • [Presentation] 共役イミンの[4+4]二量化反応を用いたアクロレイン定量法の開発2016

    • Author(s)
      土田紘也、下山敦史、田中克典、深瀬浩一
    • Organizer
      バイオ関連化学シンポジウム学会
    • Place of Presentation
      金沢
    • Year and Date
      2016-09-07
    • Related Report
      2016 Annual Research Report
  • [Presentation] Toll様受容体リガンドのライブセルイメージング解析2016

    • Author(s)
      横山康平、Qi Feng、荒井洋平、井貫晋輔、藤本ゆかり、樺山一哉、深瀬浩一
    • Organizer
      バイオ関連化学シンポジウム学会
    • Place of Presentation
      金沢
    • Year and Date
      2016-09-07
    • Related Report
      2016 Annual Research Report
  • [Presentation] マイクロフローシステムを用いたグリコシル化反応とマイクロフローシステムの小スケール化2016

    • Author(s)
      増井誠二,真鍋良幸,ジュリントン シアンツリ,徳永健斗,下山敦史,福山高英,柳 日馨,深瀬浩一
    • Organizer
      第35回日本糖質学会年会
    • Place of Presentation
      高知
    • Year and Date
      2016-09-01
    • Related Report
      2016 Annual Research Report
  • [Presentation] HaloTagテクノロジーによる生細胞への糖鎖提示とそれを用いた機能解析2016

    • Author(s)
      三宅秀斗、初村洋紀、樺山一哉、真鍋良幸、山地俊之、花田賢太郎、深瀬浩一
    • Organizer
      第35回日本糖質学会年会
    • Place of Presentation
      高知
    • Year and Date
      2016-09-01
    • Related Report
      2016 Annual Research Report
  • [Presentation] Entamoeba histolytica由来糖イノシトールリン脂質の合成と構造活性相関2016

    • Author(s)
      相羽俊彦、末原紗英、Bernin Hannah、 Lotter Hanna、井貫晋輔、深瀬浩一、藤本ゆかり
    • Organizer
      第35回日本糖質学会年会
    • Place of Presentation
      高知
    • Year and Date
      2016-09-01
    • Related Report
      2016 Annual Research Report
  • [Presentation] Synthesis of Clustered N-Modified STn Antigen as Anticancer Vaccine via Self-Adjuvanting Strategy2016

    • Author(s)
      張宗哲、真鍋良幸、藤本ゆかり、深瀬浩一
    • Organizer
      第35回日本糖質学会年会
    • Place of Presentation
      高知
    • Year and Date
      2016-09-01
    • Related Report
      2016 Annual Research Report
  • [Presentation] 蛍光標識化 lactosyl sphingosine による細胞膜脂質の動態解析2016

    • Author(s)
      新井健太、蟹江善美、蟹江 治、樺山一哉、深瀬浩一
    • Organizer
      第35回日本糖質学会年会
    • Place of Presentation
      高知
    • Year and Date
      2016-09-01
    • Related Report
      2016 Annual Research Report
  • [Presentation] 反応集積化と中分子合成:生物活性複合糖質を中心に2016

    • Author(s)
      深瀬浩一
    • Organizer
      第2回新学術領域研究「中分子戦略」若手シンポジウム
    • Place of Presentation
      鳥取
    • Year and Date
      2016-08-19
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] タンパク質翻訳後修飾糖鎖の合成研究:3分枝N-グリカン骨格の効率的構築の検討2016

    • Author(s)
      岡村壮一郎、真鍋良幸、深瀬浩一
    • Organizer
      ペプチド夏の若手勉強会
    • Place of Presentation
      八王子
    • Year and Date
      2016-07-31
    • Related Report
      2016 Annual Research Report
  • [Presentation] Chemical synthesis and immunomodulatory activity of inositol phospholipid from Entamoeba histolytica2016

    • Author(s)
      Toshihiko Aiba, Shou Nakagawa, Sae Suehara, Hannah Bernin, Hanna Lotter, Shinji Tanaka, Masato Kitamura, Toshiaki Murai, Shinsuke Inuki, Koichi Fukase, Yukari Fujimoto
    • Organizer
      第二回野依フォーラム若手育成塾研究発表会
    • Place of Presentation
      名古屋
    • Year and Date
      2016-07-21
    • Related Report
      2016 Annual Research Report
  • [Presentation] Efficient synthesis of N-glycans containing core fucose or bisecting GlcNAc2016

    • Author(s)
      Yoshiyuki Manabe, Nasahiro Nagasaki, Hiroki Syomura, Naoya Minamoto, Koichi Fukase
    • Organizer
      XXVIII International Carbohydrate Symposium (ICS2016)
    • Place of Presentation
      New Orleans, USA
    • Year and Date
      2016-07-17
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Functional evaluation of membrane glycolipids using HaloTag system.2016

    • Author(s)
      K. Kabayama, S. Miyake, T. Yamaji, K. Hanada, Y. Manabe, K. Fukase
    • Organizer
      XXVIII International Carbohydrate Symposium (ICS2016)
    • Place of Presentation
      New Orleans, USA
    • Year and Date
      2016-07-17
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Development of the novel tumor immunotherapy using alpha-gal epitope as an adjuvant.2016

    • Author(s)
      Koichi Fukase, Hao Sheng Li, Yoshiyuki Manabe, Kento Tokunaga, Naoko Terao, Shinji Takamatsu, Masahiro Tanemura, Eiji MIyoshi
    • Organizer
      XXVIII International Carbohydrate Symposium (ICS2016)
    • Place of Presentation
      New Orleans, USA
    • Year and Date
      2016-07-17
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Synthesis and immunomodulatory functions of mycobacterium peptidoglycan fragments.2016

    • Author(s)
      Q. Wang, Y. Matsuo, K. Fukase, Y. Fujimoto
    • Organizer
      XXVIII International Carbohydrate Symposium (ICS2016)
    • Place of Presentation
      Kazan, Russia
    • Year and Date
      2016-07-17
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Immunomodulating Activity of Chemically Synthesized Lipopolysaccharide Partial Structures2016

    • Author(s)
      A. Shimoyama, Y. Fujimoto, K. Fukase
    • Organizer
      XXVIII International Carbohydrate Symposium (ICS2016)
    • Place of Presentation
      New Orleans, USA
    • Year and Date
      2016-07-17
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Synthesis and immunomodulatory activities of natural and designed glycoconjugates for understanding of NKT-cell activation.2016

    • Author(s)
      T. Aiba, S. Inuki, N. Hirata, S. Suehara, E. Kashiwabara, S. Nakagawa, A. Shimoyama, K. Fukase, Yukari Fujimoto
    • Organizer
      XXVIII International Carbohydrate Symposium (ICS2016)
    • Place of Presentation
      New Orleans, USA
    • Year and Date
      2016-07-17
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] コアフコース機能調節分子の開発とそれを用いたTGF‐βシグナル制御と繊維化抑制2016

    • Author(s)
      武部智之, 真鍋良幸, 笠原里美, Yang Xiaoxiao, 樺山一哉, 深瀬浩一
    • Organizer
      第51回天然物化学談話会
    • Place of Presentation
      新潟
    • Year and Date
      2016-07-06
    • Related Report
      2016 Annual Research Report
  • [Presentation] 酸化ストレス条件下で産生する不飽和アルデヒドの反応性開拓2016

    • Author(s)
      髙松正之、深瀬浩一、田中克典
    • Organizer
      第51回天然物化学談話会
    • Place of Presentation
      新潟
    • Year and Date
      2016-07-06
    • Related Report
      2016 Annual Research Report
  • [Presentation] 細胞膜への合成糖鎖提示システムを用いたカレクチンの機能解析2016

    • Author(s)
      新井健太、樺山一哉、岡崎 俊朗、深瀬浩一
    • Organizer
      第51回天然物化学談話会
    • Place of Presentation
      新潟
    • Year and Date
      2016-07-06
    • Related Report
      2016 Annual Research Report
  • [Presentation] Synthetic and biofunctional studies of microbial and animal glycans2016

    • Author(s)
      K. Kabayama, S. Miyake, Y. Manabe, T. Yamaji, K. Hanada, K. Fukase
    • Organizer
      The 10th International Symposium on Glycosyltransferases (GlycoT2016)
    • Place of Presentation
      Toronto, Canada
    • Year and Date
      2016-06-19
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Synthetic and biofunctional studies of microbial and animal glycans2016

    • Author(s)
      Koichi Fukase
    • Organizer
      The XV Meeting-School on Carbohydrate Chemistry
    • Place of Presentation
      Siena, Italy
    • Year and Date
      2016-06-19
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 細胞表面における糖鎖機能解明を指向した合成糖鎖の細胞膜提示システムの開発2016

    • Author(s)
      三宅秀斗、樺山一哉、真鍋良幸、陳思宇、山地俊之、花田賢太郎、深瀬浩一
    • Organizer
      日本ケミカルバイオロジー学会
    • Place of Presentation
      京都
    • Year and Date
      2016-06-15
    • Related Report
      2016 Annual Research Report
  • [Presentation] 浮遊細胞のライブセルイメージング解析2016

    • Author(s)
      波多野佳奈枝・樺山一哉・岡村陽介・深瀬浩一
    • Organizer
      日本ケミカルバイオロジー学会
    • Place of Presentation
      京都
    • Year and Date
      2016-06-15
    • Related Report
      2016 Annual Research Report
  • [Presentation] 共役イミンの[4+4]環化付加反応を用いた不飽和アルデヒド検出法の開発2016

    • Author(s)
      土田紘也、下山敦史、田中克典、深瀬浩一
    • Organizer
      日本ケミカルバイオロジー学会
    • Place of Presentation
      京都
    • Year and Date
      2016-06-15
    • Related Report
      2016 Annual Research Report
  • [Presentation] ホスファチジルイノシトールの合成とそのNKT細胞刺激活性2016

    • Author(s)
      中川翔、下山敦史、相羽俊彦、藤本ゆかり、深瀬浩一
    • Organizer
      日本ケミカルバイオロジー学会
    • Place of Presentation
      京都
    • Year and Date
      2016-06-15
    • Related Report
      2016 Annual Research Report
  • [Presentation] 合成糖鎖の細胞膜提示システムによる糖脂質機能の解明2016

    • Author(s)
      樺山一哉、三宅秀斗、真鍋良幸、山地俊之、花田賢太郎、深瀬浩一
    • Organizer
      第 58 回 日本脂質生化学会
    • Place of Presentation
      秋田
    • Year and Date
      2016-06-09
    • Related Report
      2016 Annual Research Report
  • [Presentation] Synthetic Study of Immunoconjugates Composed of Tumor Antigens and Adjuvants.2016

    • Author(s)
      Koichi Fukase, Yoshiyuki Manabe, Tsung-Che Chang, Hao Sheng Li, Yukari Fujimoto, Naoko Terao, Shinji Takamatsu, Masahiro Tanemura, Eiji Miyoshi
    • Organizer
      The 16th Akabori Conference 2016 (Japanese-German Symposium on Peptide Science)
    • Place of Presentation
      Kobe
    • Year and Date
      2016-05-22
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Functional evaluation of membrane glycolipids using synthetic glycans2016

    • Author(s)
      K. Kabayama, S. Miyake, Y. Manabe, T. Yamaji, K. Hanada, K. Fukase
    • Organizer
      The 1st Korea-Japan Lipid Biology symposium
    • Place of Presentation
      Jeju, Korea
    • Year and Date
      2016-05-11
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Functional analysis of synthetic glycans on the cell membrane by input control2016

    • Author(s)
      K. Kabayama, S. Miyake, Y. Manabe, T. Yamaji, K. Hanada, K. Fukase
    • Organizer
      Frontiers in Sialic acid Research Conference
    • Place of Presentation
      Bad Lauterberg, Germany
    • Year and Date
      2016-04-23
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Glycosylation via Short Time Intermediate Using Small Scale Microfluidic System.2016

    • Author(s)
      Seiji Masui, Yoshiyuki Manabe, Sianturi Julinton, Kento Tokunaga, Koichi Fukase
    • Organizer
      The 12th International Symposium on Organic Reactions(ISOR-12)
    • Place of Presentation
      Kyoto
    • Year and Date
      2016-04-22
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Synthetic and Bio-functional Study of Glycans2016

    • Author(s)
      Koichi Fukase
    • Organizer
      The 12th International Symposium on Organic Reactions(ISOR-12)
    • Place of Presentation
      Kyoto
    • Year and Date
      2016-04-22
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Chemical Synthesis of Immunomodulative Lipopolysaccharide Partial Structures2016

    • Author(s)
      Atsushi Shimoyama, Yukari Fujimoto, Koichi Fukase
    • Organizer
      The 12th International Symposium on Organic Reactions(ISOR-12)
    • Place of Presentation
      Kyoto
    • Year and Date
      2016-04-22
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Synthesis of Clustered Type of Mucin-Related N-Modified STn Antigen as AnticancerVaccine Candidate via Fully Synthetic Self-Adjuvanting Strategy.2016

    • Author(s)
      Tsung-che Chang, Yoshiyuki Manabe, Yukari Fujimoto, Koichi Fukase
    • Organizer
      The 12th International Symposium on Organic Reactions(ISOR-12)
    • Place of Presentation
      Kyoto
    • Year and Date
      2016-04-22
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] PETならびに蛍光イメージングで探る糖鎖機能2016

    • Author(s)
      深瀬浩一
    • Organizer
      日本化学会第96回春季年会
    • Place of Presentation
      京都
    • Year and Date
      2016-03-24
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 糖鎖抗原 α-gal エピトープの効率合成と新規がん療法への適用2016

    • Author(s)
      徳永健斗、真鍋良幸、樺山一哉、深瀬浩一
    • Organizer
      日本化学会第96回春季年会
    • Place of Presentation
      京都
    • Year and Date
      2016-03-24
    • Related Report
      2015 Annual Research Report
  • [Presentation] インフルエンザ感染阻害剤開発を目指した糖鎖クラスターの合成研究2016

    • Author(s)
      市川浩章、真鍋良幸、深瀬浩一
    • Organizer
      日本化学会第96回春季年会
    • Place of Presentation
      京都
    • Year and Date
      2016-03-24
    • Related Report
      2015 Annual Research Report
  • [Presentation] 効率的分枝構造形成を鍵とするバイセクティング型糖鎖の合成2016

    • Author(s)
      初村 洋紀・真鍋 良幸・源 直也・長崎 政裕・深瀬 浩一
    • Organizer
      日本化学会第96回春季年会
    • Place of Presentation
      京都
    • Year and Date
      2016-03-24
    • Related Report
      2015 Annual Research Report
  • [Presentation] 水素結合ネットワークの形成阻害による反応性向上を鍵としたABO式血液型糖鎖の合成研究2016

    • Author(s)
      筒井正斗・真鍋良幸・深瀬浩一
    • Organizer
      日本化学会第96回春季年会
    • Place of Presentation
      京都
    • Year and Date
      2016-03-24
    • Related Report
      2015 Annual Research Report
  • [Presentation] フロー系の小スケール化とそれを用いた糖トリフラート体経由のグリコシル化反応2016

    • Author(s)
      増井誠二、真鍋良幸、徳永健斗、深瀬浩一
    • Organizer
      日本化学会第96回春季年会
    • Place of Presentation
      京都
    • Year and Date
      2016-03-24
    • Related Report
      2015 Annual Research Report
  • [Presentation] 内因性CD1dリガンドとしてのホスファチジルイノシトールの合成とその生理活性2016

    • Author(s)
      中川 翔、下山敦史、相羽俊彦、藤本ゆかり、深瀬浩一
    • Organizer
      日本化学会第96回春季年会
    • Place of Presentation
      京都
    • Year and Date
      2016-03-24
    • Related Report
      2015 Annual Research Report
  • [Presentation] 光親和性標識化ペプチドグリカンフラグメントの合成と機能2016

    • Author(s)
      富澤一美、下山敦史、王 倩倩、藤本ゆかり、深瀬浩一
    • Organizer
      日本化学会第96回春季年会
    • Place of Presentation
      京都
    • Year and Date
      2016-03-24
    • Related Report
      2015 Annual Research Report
  • [Presentation] 機能集積中分子の創製を目指して:反応集積による合成的アプローチ2016

    • Author(s)
      深瀬浩一
    • Organizer
      生命分子機能研究会セミナー2016「生命分子・ペプチド科学に基づく創薬:医療への貢献」
    • Place of Presentation
      滋賀
    • Year and Date
      2016-03-18
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Synthesis and Bio-functional Studies of Immunomodulating Lipopolysaccharide Partial Structures2016

    • Author(s)
      Atsushi Shimoyama, Yukari Fujimoto, Koichi Fukase
    • Organizer
      The 8th Takeda Science Foundation Symposium on PharmaScience
    • Place of Presentation
      Osaka
    • Year and Date
      2016-01-21
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Synthesis and immunomodulatory activity of unique protozoal inositol phospholipids containing long fatty acids2016

    • Author(s)
      Toshihiko Aiba, Sae Suehara, Hannah Bernin, Hanna Lotter, Shinsuke Inuki, Koichi Fukase, Yukari Fujimoto
    • Organizer
      The 8th Takeda Science Foundation Symposium on PharmaSciences
    • Place of Presentation
      Osaka
    • Year and Date
      2016-01-21
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Development of New Generation Cancer Vaccines: Conjugation of Antigens with Adjuvants2016

    • Author(s)
      Yoshiyuki Manabe, HaoSheng Li, Kento Tokunaga, Naoko Terao, Shinji Takamatsu, Masahiro Tanemura, Eiji Miyoshi, Koichi Fukase
    • Organizer
      The 8th Takeda Science Foundation Symposium on PharmaScience
    • Place of Presentation
      Osaka
    • Year and Date
      2016-01-21
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 中分子戦略と医理連携2016

    • Author(s)
      深瀬浩一
    • Organizer
      日本化学会フロンティア生命化学研究会
    • Place of Presentation
      長崎
    • Year and Date
      2016-01-08
    • Related Report
      2015 Annual Research Report
  • [Presentation] Development of the small-scale microfluidic system and investigation of efficient glycosylations under microfluidic condition2016

    • Author(s)
      Seiji Masui, Yoshiyuki Manabe, Sianturi Julinton, Kento Tokunaga, Atsushi Shimoyama, Takahide Fukuyama, Ilhyong Ryu and Koichi Fukase
    • Organizer
      Shanghai Institute of Organic Chemistry - Osaka University Workshop on Glycoscience
    • Place of Presentation
      豊中
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Middle Molecular Strategy for Efficient Tumor Immunotherapy: Conjugation of Antigens with Adjuvants2016

    • Author(s)
      Yoshiyuki Manabe, Koichi Fukase
    • Organizer
      The 2nd International Symposium on Middle Molecular Strategy (ISMMS-2)
    • Place of Presentation
      豊中
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Development of the novel tumor immunotherapy: conjugation of tumor antigens with adjuvants.2016

    • Author(s)
      Yoshiyuki Manabe, Koichi Fukase
    • Organizer
      タンパク研セミナー:Frontiers of peptide and glycoscience
    • Place of Presentation
      Suita
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] FUT8阻害剤の創製-多様性指向型合成法の開拓High Throughput Screeningによる探索2016

    • Author(s)
      真鍋良幸、笠原里実、高倉陽平、深瀬浩一
    • Organizer
      第3回FCCAシンポジウム FCCAグライコサイエンス若手フォーラム2016
    • Place of Presentation
      湘南
    • Related Report
      2016 Annual Research Report
  • [Presentation] コアフコースの機能制御分子の創製:コアフコース認識ペプチドとFUT8阻害剤の探索2016

    • Author(s)
      髙倉陽平,真鍋良幸,笠原里美,Yang Xiaoxiao,奥村江里香,深瀬浩一
    • Organizer
      第3回FCCAシンポジウム FCCAグライコサイエンス若手フォーラム2016
    • Place of Presentation
      湘南
    • Related Report
      2016 Annual Research Report
  • [Presentation] 収束的ルートによる分枝構造形成を鍵とするバイセクティング型糖鎖の合成2016

    • Author(s)
      初村洋紀、真鍋良幸、源直也、長崎政裕、深瀬浩一
    • Organizer
      第36回有機合成若手セミナー
    • Place of Presentation
      京都
    • Related Report
      2016 Annual Research Report
  • [Presentation] HloTagを用いた細胞表層糖鎖提示システムの開発と機能解析2016

    • Author(s)
      三宅秀斗、初村洋紀、樺山一哉、真鍋良幸、山地俊之、花田賢太郎、深瀬浩一
    • Organizer
      第36回有機合成若手セミナー
    • Place of Presentation
      京都
    • Related Report
      2016 Annual Research Report
  • [Presentation] 収束的ルートによる3分枝N-グリカンの合成研究2016

    • Author(s)
      岡村壮一郎、真鍋良幸、深瀬浩一
    • Organizer
      第36回有機合成若手セミナー
    • Place of Presentation
      京都
    • Related Report
      2016 Annual Research Report
  • [Presentation] 反応集積化と中分子複合糖質合成2016

    • Author(s)
      深瀬浩一
    • Organizer
      有機合成化学協会東海支部総合講演会
    • Place of Presentation
      岐阜
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 水素結合の形成阻害を鍵としたABO式血液型糖鎖の合成研究2016

    • Author(s)
      筒井正斗・真鍋良幸・深瀬浩一
    • Organizer
      第3回FCCAシンポジウム FCCAグライコサイエンス若手フォーラム2016
    • Place of Presentation
      湘南
    • Related Report
      2016 Annual Research Report
  • [Presentation] 生物活性中分子の合成を目指して:複合糖質を中心に2016

    • Author(s)
      深瀬浩一
    • Organizer
      フィッシャー祭
    • Place of Presentation
      吹田
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 化学合成ワクチンの開発を目指して2016

    • Author(s)
      深瀬浩一
    • Organizer
      第3回次世代の有機化学・広島シンポジウム
    • Place of Presentation
      東広島
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 糖鎖を介した自己と非自己の認識と免疫制御への展開2016

    • Author(s)
      深瀬浩一
    • Organizer
      第96 回未来医療セミナー
    • Place of Presentation
      吹田
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 共役イミンの環化付加反応を用いた不飽和アルデヒド検出法の開発2016

    • Author(s)
      土田紘也、下山敦史、田中克典、深瀬浩一
    • Organizer
      ペプチド夏の若手勉強会
    • Place of Presentation
      八王子
    • Related Report
      2016 Annual Research Report
  • [Presentation] 自己と非自己の認識に関わる糖鎖の機能解析と免疫調節への利用2016

    • Author(s)
      深瀬浩一
    • Organizer
      公益財団法人サントリー生命科学財団創立70周年記念 中西重忠シンポジウム
    • Place of Presentation
      相楽郡
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Kinetically controlled Fischer glycosylation using acidic silica-gel under fluidic conditions2015

    • Author(s)
      Seiji Masui, Yoshiyuki Manabe, Atsushi Shimoyama, Takahide Fukuyama, Ilhyong Ryu, Koichi Fukase
    • Organizer
      PACIFICHEM2015
    • Place of Presentation
      Hawaii
    • Year and Date
      2015-12-15
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] In vivo production of eight-membered heterocycles from acrolein and transformation to 3-formyl-3,4-dehydropiperidine (FDP)2015

    • Author(s)
      Masayuki Takamatsu, Koichi Fukase, Katsunori Tanaka
    • Organizer
      PACIFICHEM2015
    • Place of Presentation
      Hawaii
    • Year and Date
      2015-12-15
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Synthesis and biological activity of phosphatidylinositol for the elucidation of NKT cell pre-activation mechanism2015

    • Author(s)
      Nakagawa, Sho; Shimoyama, Atsushi; Aiba, Toshihiko; Fujimoto, Yukari; Koichi, Fukase
    • Organizer
      PACIFICHEM2015
    • Place of Presentation
      Hawaii
    • Year and Date
      2015-12-15
    • Related Report
      2015 Annual Research Report
  • [Presentation] A Novel Approach in Cancer Immunotherapy: Using Synthetic α-gal Epitope to Increase the Immunogenicity of Tumor Antigens2015

    • Author(s)
      HaoSheng Li, Yoshiyuki Manabe, Kento Tokunaga, Naoko Terao, Shinji Takamatsu, Masahiro Tanemura, Eiji Miyoshi, Koichi Fukase
    • Organizer
      PACIFICHEM2015
    • Place of Presentation
      Hawaii
    • Year and Date
      2015-12-15
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Dehydration of Alcohols in a Flow System Using Acid-Functionalized Silica Gel: Application to the Synthesis of Pristane2015

    • Author(s)
      Furuta Akihiro, Hirobe Yuki, Fukuyama Takahide, Ryu Ilhyong, Manabe Yoshiyuki, Fukase Koichi
    • Organizer
      PACIFICHEM2015
    • Place of Presentation
      Hawaii
    • Year and Date
      2015-12-15
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] フローマイクロ合成を利用した複合糖質の合成とその免疫制御機能2015

    • Author(s)
      深瀬浩一
    • Organizer
      有機合成化学講習会
    • Place of Presentation
      東京
    • Year and Date
      2015-11-16
    • Related Report
      2015 Annual Research Report
  • [Presentation] SYNTHESIS OF THE CONJUGATES OF TUMOR ANTIGENS WITH ADJUVANTS FOR THE EFFICIENT CANCER IMMUNOTHERAPY2015

    • Author(s)
      Yoshiyuki Manabe, Tsung-Che Chang, HaoSheng Li, Naoko Terao, Shinji Takamatsu, Masahiro Tanemura, Eiji Miyoshi, Koichi Fukase
    • Organizer
      第52回ペプチド討論会
    • Place of Presentation
      神奈川
    • Year and Date
      2015-11-16
    • Related Report
      2015 Annual Research Report
  • [Presentation] Characterization of LPS/lipid A from Alcaligenes sp.2015

    • Author(s)
      Keisuke Mizote, Atsushi Shimoyama, Naoko Shibata, Flanviana D. Lorenzo, Yukari Fujimoto, Antonio Molinaro, Jun Kunisawa, Hiroshi Kiyono, Koichi Fukase
    • Organizer
      7th Asian Community of Glycoscience and Glycotechnology Conference
    • Place of Presentation
      Miyagi
    • Year and Date
      2015-11-12
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Synthesis and Bio-functional Studies of Immunomodulating LPS Partial Structures2015

    • Author(s)
      Atsushi Shimoyama, Keisuke Mizote, Yuakri Fujimoto, Koichi Fukase
    • Organizer
      the 13th International Kyoto Conference on New Aspects of Organic Chemistry (IKCOC-13)
    • Place of Presentation
      Kyoto
    • Year and Date
      2015-11-09
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Fully synthetic self-adjuvanting antitumor vaccine candidate consisting of N-modified TriSTn antigen combined with lipopeptide and T-helper-cell-epitope2015

    • Author(s)
      CHANG, Tsung-che; MANABE, Yoshiyuki; FUJIMOTO, Yukari; FUKASE, Koichi
    • Organizer
      the 13th International Kyoto Conference on New Aspects of Organic Chemistry (IKCOC-13)
    • Place of Presentation
      Kyoto
    • Year and Date
      2015-11-09
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Development of Novel Tumor Vaccine Using Synthetic α-Gal as an Adjuvant2015

    • Author(s)
      Yoshiyuki Manabe, HaoSheng Li, Kento Tokunaga, Naoko Terao, Shinji Takamatsu, Masahiro Tanemura, Eiji Miyoshi, Koichi Fukase
    • Organizer
      the 13th International Kyoto Conference on New Aspects of Organic Chemistry (IKCOC-13)
    • Place of Presentation
      Kyoto
    • Year and Date
      2015-11-09
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Efficient Synthesis of Complex-Type N-Glycans2015

    • Author(s)
      Masahiro Nagasaki, Naoya Minamoto, Hiroki Shomura, Yoshiyuki Manabe, Katsunori Tanaka, Koichi Fukase
    • Organizer
      the 13th International Kyoto Conference on New Aspects of Organic Chemistry (IKCOC-13)
    • Place of Presentation
      Kyoto
    • Year and Date
      2015-11-09
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 内因性CD1dリガンドの探索を目指したホスファチジルイノシトールの合成とその生理活性2015

    • Author(s)
      中川 翔、下山敦史、相羽俊彦、藤本ゆかり、深瀬浩一
    • Organizer
      第5回CSJ化学フェスタ2015
    • Place of Presentation
      東京
    • Year and Date
      2015-10-13
    • Related Report
      2015 Annual Research Report
  • [Presentation] アミド基のイミド保護による反応性向上を鍵としたABO式血液型糖鎖の合成研究2015

    • Author(s)
      筒井正斗・真鍋良幸・深瀬浩一
    • Organizer
      第5回CSJ化学フェスタ2015
    • Place of Presentation
      東京
    • Year and Date
      2015-10-13
    • Related Report
      2015 Annual Research Report
  • [Presentation] 収束的ルートによるバイセクティング型糖鎖の効率合成2015

    • Author(s)
      初村洋紀、真鍋良幸、源 直也、長崎政裕、深瀬浩一
    • Organizer
      第5回CSJ化学フェスタ2015
    • Place of Presentation
      東京
    • Year and Date
      2015-10-13
    • Related Report
      2015 Annual Research Report
  • [Presentation] Synthesis and Biofunctional Study of Immunomodulative Lipopolysaccharide Partial Structures2015

    • Author(s)
      Atsushi Shimoyama, Keisuke Mizote, Yukari Fujimoto, Koichi Fukase
    • Organizer
      23rd International Symposium on Glycoconjugates (Glyco23)
    • Place of Presentation
      Split, Croatia
    • Year and Date
      2015-09-15
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Synthesis and Biological Activity of Inositol Phospholipid as NKT Cell Modulator2015

    • Author(s)
      Toshihiko Aiba, Sae Suehara, Hannah Bernin, Hanna Lotter, Shinsuke Inuki, Koichi Fukase, Yukari Fujimoto
    • Organizer
      23rd International Symposium on Glycoconjugates (Glyco23)
    • Place of Presentation
      Split, Croatia
    • Year and Date
      2015-09-15
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] α1,6‐フコシルトランスフェラーゼ阻害剤の細胞における機能評価2015

    • Author(s)
      武部智之、真鍋良幸、笠原里美、Yang Xiaoxiao、樺山一哉、深瀬浩一
    • Organizer
      第9回バイオ関連化学シンポジウム
    • Place of Presentation
      熊本
    • Year and Date
      2015-09-10
    • Related Report
      2015 Annual Research Report
  • [Presentation] α-galエピトープをアジュバントとして利用する革新的がんワクチン療法の開発2015

    • Author(s)
      真鍋良幸,李 昊晟,寺尾尚子,高松真二,種村匡弘,三善英知,深瀬浩一
    • Organizer
      第9回バイオ関連化学シンポジウム
    • Place of Presentation
      熊本
    • Year and Date
      2015-09-10
    • Related Report
      2015 Annual Research Report
  • [Presentation] Synthetic and biofunctional studies of glycoconjugates toward immunoregulation2015

    • Author(s)
      Fukase, K.
    • Organizer
      18th European Carbohydrate Symposium (Eurocarb18)
    • Place of Presentation
      Moscow, Russia
    • Year and Date
      2015-08-02
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] α1,6‐フコシルトランスフェラーゼ阻害剤の細胞毒性および機能評価2015

    • Author(s)
      武部智之, 真鍋良幸, 笠原里美, Yang Xiaoxiao, 樺山一哉, 深瀬浩一
    • Organizer
      第35回有機合成若手セミナー「明日の有機合成を担う人のために」
    • Place of Presentation
      京都
    • Year and Date
      2015-08-01
    • Related Report
      2015 Annual Research Report
  • [Presentation] Entamoeba histolytica由来GPI アンカー部分構造の合成と生物活性2015

    • Author(s)
      相羽俊彦、末原紗英、Bernin Hannah、 Lotter Hanna、井貫晋輔、深瀬浩一、藤本ゆかり
    • Organizer
      第34回日本糖質学会年会
    • Place of Presentation
      東京
    • Year and Date
      2015-07-31
    • Related Report
      2015 Annual Research Report
  • [Presentation] NKT細胞の活性化機構解明を目指した_ホスファチジルイノシトールの合成とその生理活性2015

    • Author(s)
      中川翔、下山敦史、相羽俊彦、藤本ゆかり、深瀬浩一
    • Organizer
      第34回日本糖質学会年会
    • Place of Presentation
      東京
    • Year and Date
      2015-07-31
    • Related Report
      2015 Annual Research Report
  • [Presentation] Synthetic and biofunctional studies of microbial and animal glycan2015

    • Author(s)
      Fukase, K.
    • Organizer
      Centro de Investigaciones Biologicas, CIB-CSIC
    • Place of Presentation
      Madrid, Spain
    • Year and Date
      2015-06-29
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Book] [1]ペプチド医薬品のスクリーニング・安定化・製剤化技術 第10章6節 セルフアジュバンティングストラテジーによる合成ワクチン開発2017

    • Author(s)
      下山敦史,真鍋良幸,深瀬浩一
    • Total Pages
      8
    • Publisher
      技術情報協会
    • ISBN
      4861046874
    • Related Report
      2017 Annual Research Report
  • [Book] [4]アジュバントとしてのリピドA、次世代アジュバント開発のためのメカニズム解明と安全性評価2017

    • Author(s)
      下山敦史, 深瀬浩一
    • Total Pages
      12
    • Publisher
      シーエムシー出版
    • ISBN
      9784781312385
    • Related Report
      2017 Annual Research Report
  • [Book] アジュバントとしてのリピドA、次世代アジュバント開発のためのメカニズム解明と安全性評価2017

    • Author(s)
      下山敦史, 深瀬浩一
    • Publisher
      シーエムシー出版
    • Related Report
      2016 Annual Research Report
  • [Remarks] 深瀬研究室ホームページ

    • URL

      http://www.chem.sci.osaka-u.ac.jp/lab/fukase/

    • Related Report
      2019 Annual Research Report
  • [Remarks] 反応集積化が導く中分子戦略:高次生物機能分子の創製

    • URL

      http://www.middle-molecule.jp/

    • Related Report
      2015 Annual Research Report
  • [Patent(Industrial Property Rights)] At-211アスタチン標識金ナノ粒子の局所投与による悪性腫瘍増殖抑制2021

    • Inventor(s)
      加藤弘樹、深瀬浩一、樺山一哉、下山敦史、角永悠一郎ら
    • Industrial Property Rights Holder
      加藤弘樹、深瀬浩一、樺山一哉、下山敦史、角永悠一郎ら
    • Industrial Property Rights Type
      特許
    • Filing Date
      2021
    • Related Report
      2019 Annual Research Report
  • [Patent(Industrial Property Rights)] 金ナノ粒子含有医薬2020

    • Inventor(s)
      加藤弘樹、深瀬浩一、樺山一哉、下山敦史、角永悠一郎ら
    • Industrial Property Rights Holder
      加藤弘樹、深瀬浩一、樺山一哉、下山敦史、角永悠一郎ら
    • Industrial Property Rights Type
      特許
    • Filing Date
      2020
    • Related Report
      2019 Annual Research Report
  • [Patent(Industrial Property Rights)] がん細胞型大型中性アミノ酸トランスポーターLAT1に親和性を有するアミノ酸誘導体を211Atラベル化した抗がん剤とアスコルビン酸による211Atラベル化化合物の安定化法2018

    • Inventor(s)
      深瀬浩一
    • Industrial Property Rights Holder
      深瀬浩一
    • Industrial Property Rights Type
      特許
    • Filing Date
      2018
    • Related Report
      2017 Annual Research Report
  • [Patent(Industrial Property Rights)] ホウ素クラスター脂質へのヨウ素ならびにアスタチン標識化法と標識化ホウ素クラスター脂質のウイルス様粒子への導入法2018

    • Inventor(s)
      深瀬浩一
    • Industrial Property Rights Holder
      深瀬浩一
    • Industrial Property Rights Type
      特許
    • Filing Date
      2018
    • Related Report
      2017 Annual Research Report
  • [Patent(Industrial Property Rights)] リピドA2017

    • Inventor(s)
      國澤 純、深瀬 浩一、清野 宏
    • Industrial Property Rights Holder
      國澤 純、深瀬 浩一、清野 宏
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2017-030179
    • Filing Date
      2017-02-21
    • Related Report
      2016 Annual Research Report

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Published: 2015-07-02   Modified: 2022-11-04  

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