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Development for the functional middle size molecules to the high ordered nucleic acidsstructure

Planned

Project AreaMiddle molecular strategy: Creation of higher bio-functional molecules by integrated synthesis.
Project/Area Number 15H05838
Research Category

Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

Allocation TypeSingle-year Grants
Review Section Science and Engineering
Research InstitutionTohoku University

Principal Investigator

Nagatsugi Fumi  東北大学, 多元物質科学研究所, 教授 (90208025)

Co-Investigator(Kenkyū-buntansha) 鬼塚 和光  東北大学, 多元物質科学研究所, 准教授 (00707961)
Project Period (FY) 2015-06-29 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥45,500,000 (Direct Cost: ¥35,000,000、Indirect Cost: ¥10,500,000)
Fiscal Year 2019: ¥8,840,000 (Direct Cost: ¥6,800,000、Indirect Cost: ¥2,040,000)
Fiscal Year 2018: ¥8,840,000 (Direct Cost: ¥6,800,000、Indirect Cost: ¥2,040,000)
Fiscal Year 2017: ¥8,840,000 (Direct Cost: ¥6,800,000、Indirect Cost: ¥2,040,000)
Fiscal Year 2016: ¥8,840,000 (Direct Cost: ¥6,800,000、Indirect Cost: ¥2,040,000)
Fiscal Year 2015: ¥10,140,000 (Direct Cost: ¥7,800,000、Indirect Cost: ¥2,340,000)
Keywords核酸高次構造 / アルキル化 / 中分子 / RNA高次構造 / グアニン4重鎖 / ノンコーディングRNA / 機能性中分子 / RNA結合分子 / アルキル化反応 / グアニン4重鎖 / G-カルテット構造 / 反応性プローブ / RNA 高次構造 / RNA 結合分子
Outline of Final Research Achievements

DNA and RNA can also adopt great varieties of stable higher-order structure motifs, such as the G-quadruplex (G4s), mismatch and bulge. Many of these secondary structures were found to be closely related to the control of the gene expression. Therefore, the higher-order structure of nucleic acids is one of the candidates for therapeutic targets. Due to the therapeutic potentials, efforts on the development of small molecule binders to specifically target the higher-order structures of nucleic acids have been intensely carried out. With the aim to augment the stabilization effect, selective alkylation using small molecules targeting the higher-order structures of nucleic acids have also been pursued. In this research we developed the new middle-size molecules with the binding group to target nucleic acids and the alkylating moiety, for alkylation to higher-order structures of nucleic acids.

Academic Significance and Societal Importance of the Research Achievements

核酸の高次構造は、最近、特に種々の機能性RNAにおいてその機能を担うモチーフとして、重要であることがわかってきている。現在、世界を震撼させているコロナウイルスはRNAウイルスであり、構造内には高次構造を持つ。すなわちこれらのRNAの構造に結合する中分子は、RNAウイルスのRNAに結合し、ウイルスの増殖阻害に繋がる可能性がある。今回、申請者らが開発したアルキル化プローブは、特定の高次構造に結合し、反応性がONになるという非常に興味深い性質を持っており学術的意義は高い。さらに、RNAの高次構造に結合する分子も見出しており、社会的意義も非常に高いと考えている。

Report

(6 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Annual Research Report
  • 2017 Annual Research Report
  • 2016 Annual Research Report
  • 2015 Annual Research Report

Research Products

(157 results)

All 2020 2019 2018 2017 2016 2015 Other

All Int'l Joint Research (3 results) Journal Article (20 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 18 results,  Open Access: 8 results,  Acknowledgement Compliant: 6 results) Presentation (130 results) (of which Int'l Joint Research: 56 results,  Invited: 19 results) Remarks (4 results)

  • [Int'l Joint Research] ジュネーブ大学(スイス)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] Department of Chemistry, UC Davis(アメリカ)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] Depertment of Chemistry/University of California(アメリカ)

    • Related Report
      2016 Annual Research Report
  • [Journal Article] Liquid-like droplet formation by tumor suppressor p53 induced by multivalent electrostatic interactions between two disordered domains2020

    • Author(s)
      Kamagata Kiyoto、Kanbayashi Saori、Honda Masaya、Itoh Yuji、Takahashi Hiroto、Kameda Tomoshi、Nagatsugi Fumi、Takahashi Satoshi
    • Journal Title

      Scientific Reports

      Volume: 10 Pages: 580-580

    • DOI

      10.1038/s41598-020-57521-w

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] DNAの狙った構造だけを化学修飾する!2020

    • Author(s)
      永次 史、鬼塚 和光
    • Journal Title

      化学

      Volume: 75 Pages: 52-56

    • Related Report
      2019 Annual Research Report
    • Open Access
  • [Journal Article] Development of the binding molecules for the RNA higher-order structures based on the guanine-recognition by the G-clamp2019

    • Author(s)
      Murase Hirotaka、Nagatsugi Fumi
    • Journal Title

      Bioorganic & Medicinal Chemistry Letters

      Volume: 29 Pages: 1320-1324

    • DOI

      10.1016/j.bmcl.2019.03.052

    • Related Report
      2019 Annual Research Report 2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Reactive OFF-ON type alkylating agents for higher-ordered structures of nucleic acids2019

    • Author(s)
      Onizuka Kazumitsu、Hazemi Madoka E、Sato Norihiro、Tsuji Gen-ichiro、Ishikawa Shunya、Ozawa Mamiko、Tanno Kousuke、Yamada Ken、Nagatsugi Fumi
    • Journal Title

      Nucleic Acids Research

      Volume: 47 Pages: 6578-6589

    • DOI

      10.1093/nar/gkz512

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Alkyne-Alkyne Photo-cross-linking on the Flipping-out Field2019

    • Author(s)
      Onizuka Kazumitsu、Ishida Kei、Mano Eriko、Nagatsugi Fumi
    • Journal Title

      Organic Letters

      Volume: 21 Pages: 2833-2837

    • DOI

      10.1021/acs.orglett.9b00817

    • Related Report
      2019 Annual Research Report 2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Synthesis of RNA Crosslinking Oligonucleotides Modified with 2‐Amino‐7‐Deaza‐7‐Propynyl‐6‐Vinylpurine2019

    • Author(s)
      Yamada Ken、Abe Yusuke、Nagatsugi Fumi
    • Journal Title

      Current Protocols in Nucleic Acid Chemistry

      Volume: 77

    • DOI

      10.1002/cpnc.79

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Synthesis and Properties of 2′-OMe-RNAs Modified with Cross-Linkable 7-Deazaguanosine Derivatives2018

    • Author(s)
      Yamada Ken、Abe Yusuke、Murase Hirotaka、Ida Yuta、Hagihara Shinya、Nagatsugi Fumi
    • Journal Title

      The Journal of Organic Chemistry

      Volume: 83 Pages: 8851-8862

    • DOI

      10.1021/acs.joc.8b01002

    • Related Report
      2018 Annual Research Report
  • [Journal Article] Alkylating probes for the G-quadruplex structure and evaluation of the properties of the alkylated G-quadruplex DNA2018

    • Author(s)
      Sato Norihiro、Takahashi Shuntaro、Tateishi-Karimata Hisae、Hazemi Madoka E.、Chikuni Tomoko、Onizuka Kazumitsu、Sugimoto Naoki、Nagatsugi Fumi
    • Journal Title

      Organic & Biomolecular Chemistry

      Volume: 16 Pages: 1436-1441

    • DOI

      10.1039/c7ob03179c

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Selective alkylation of T-T mismatched DNA using vinyldiaminotriazine-acridine conjugate2018

    • Author(s)
      Onizuka Kazumitsu、Usami Akira、Yamaoki Yudai、Kobayashi Tomohito、Hazemi Madoka E、Chikuni Tomoko、Sato Norihiro、Sasaki Kaname、Katahira Masato、Nagatsugi Fumi
    • Journal Title

      Nucleic Acids Research

      Volume: 46 Pages: 1059-1068

    • DOI

      10.1093/nar/gkx1278

    • NAID

      120006466620

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Structural optimization of pseudorotaxane-forming oligonucleotides for efficient and stable complex formation2018

    • Author(s)
      Onizuka Kazumitsu、Miyashita Takuya、Chikuni Tomoko、Ozawa Mamiko、Abe Hiroshi、Nagatsugi Fumi
    • Journal Title

      Nucleic Acids Research

      Volume: 46 Pages: 8710-8719

    • DOI

      10.1093/nar/gky744

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Vinyldiaminotriazine-acridine conjugate as G-quadruplex alkylating agent2018

    • Author(s)
      Hazemi Madoka E.、Onizuka Kazumitsu、Kobayashi Tomohito、Usami Akira、Sato Norihiro、Nagatsugi Fumi
    • Journal Title

      Bioorganic & Medicinal Chemistry

      Volume: 26 Pages: 3551-3558

    • DOI

      10.1016/j.bmc.2018.05.030

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Synthesis and properties of Cross-linkable DNA duplex using 4-Amino-2-Oxo-6-vinyl-1,3,5-Triazine2017

    • Author(s)
      Yamada,K.; Ishiyama,S.; Onizuka,K.; Nagatsugi,F.
    • Journal Title

      Tetrahedron

      Volume: 73 Pages: 1424-1435

    • DOI

      10.1016/j.tet.2017.01.043

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Synthesis of native-like crosslinked duplex RNA and study of its properties2017

    • Author(s)
      Kazumitsu Onizuka, Madoka E. Hazemi, Justin M. Thomas, Leanna R. Monteleone, Ken Yamada, Shuhei Imoto, Peter Beal, Fumi Nagatsugi
    • Journal Title

      Bioorganic & Medicinal Chemistry

      Volume: 25 Pages: 2191-2191

    • DOI

      10.1016/j.bmc.2017.02.034

    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Pseudorotaxane formation via the slippage process with chemically-cyclized oligonucleotides2017

    • Author(s)
      Kazumitsu Onizuka, Tomoko Chikuni, Takuya Amemiya, Takuya Miyashita, Kyoko Onizuka, Hiroshi Abe, Fumi Nagatsugi
    • Journal Title

      Nucleic Acids Research

      Volume: 印刷中 Pages: 5036-5047

    • DOI

      10.1093/nar/gkx265

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Synthesis of Water-Soluble Triazinophanes and Evaluation of Their Molecular Recognition Properties2017

    • Author(s)
      Kusano Shuhei、Konishi Sae、Ishikawa Ryuta、Sato Norihiro、Kawata Satoshi、Nagatsugi Fumi、Hayashida Osamu
    • Journal Title

      European Journal of Organic Chemistry

      Volume: 2017 Pages: 1618-1623

    • DOI

      10.1002/ejoc.201601663

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Synthesis of peptide nucleic acids (PNA) with a crosslinking agent to RNA and effective inhibition of dicer2016

    • Author(s)
      Akisawa Takuya, Yamada Ken, Nagatsugi Fumi
    • Journal Title

      Bioorganic & Medicinal Chemistry Letters

      Volume: 26 Pages: 5902-5906

    • DOI

      10.1016/j.bmcl.2016.11.002

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Crosslinking reactions of 4-amino-6-oxo-2-vinylpyrimidine with guanine derivatives and structural analysis of the adducts2015

    • Author(s)
      S.Kusano, S. Ishiyama,Sik Lok Lam, T. Mashima, M. Katahira, K. Miyamoto, M. Aida, F. Nagatsugi
    • Journal Title

      Nucleic Acids Res.

      Volume: 43 Pages: 7717-7730

    • DOI

      10.1093/nar/gkv797

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] A New Strategy for Site-Specific Alkylation of DNA using Oligonucleotides Containing an Abasic site and Alkylating Probes2015

    • Author(s)
      N. Sato, G. Tsuji, Y. Sasaki, A. Usami, T. Moki, K. Onizuka, K. Yamada and F. Nagatsugi
    • Journal Title

      Chem.Commun.

      Volume: 51 Pages: 14885-14888

    • DOI

      10.1039/c5cc03915k

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Stabilization of the i-motif structure by the intra-strand cross-link formation.2015

    • Author(s)
      K. Kikuta, H. Piao, J. Brazier, ,Y. Taniguchi, K.Onizuka, F. Nagatsugi, S. Sasaki
    • Journal Title

      Bioorg. Med. Chem. Lett.

      Volume: 25 Pages: 3307-3310

    • DOI

      10.1016/j.bmcl.2015.05.064

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Synthesis of Peptide Nucleic Acids Containing a Crosslinking Agent and Evaluation of Their Reactivities.2015

    • Author(s)
      T. Akisawa, Y. Ishizawa, F. Nagatsugi
    • Journal Title

      Molecules

      Volume: 20 Pages: 4708-4719

    • DOI

      10.3390/molecules20034708

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] 化学修飾アプタマーの探索を指向した新規人工ヌクレオシドの創製2020

    • Author(s)
      伊藤 理奈・岡村 秀紀・永次 史
    • Organizer
      日本化学会 第100春季年会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 付加的な水素結合部位を付与したヌクレオシド類縁体による直行型塩基対形成2020

    • Author(s)
      岡村 秀紀・Trinh Hoang Giang・永次 史
    • Organizer
      日本化学会 第100春季年会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Development of the novel artificial nucleic acids to induce the base flipping out2020

    • Author(s)
      YAJIMA, Sayaka; ONIZUKA, Kazumitsu; ISHIDA, Kei; NAGATSUGI, Fumi
    • Organizer
      日本化学会 第100春季年会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 核酸塩基フリップアウト場における特異な化学反応2020

    • Author(s)
      鬼塚 和光、石田 圭、矢島 さやか、間野 絵梨子、永次 史
    • Organizer
      日本薬学会 第140年会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Reactive OFF-ON type alkylating agents for higher-ordered structures of nucleic acids2019

    • Author(s)
      F. Nagatsugi, M. HAZEMI, E. Ganbold, K. Onizuka
    • Organizer
      The 4th A3 Roundtable Meeting on Chemical Probe Research Hub, Sendai, Japan
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 遺伝子発現制御を目指した核酸の特殊反応場における選択的化学反応の開発2019

    • Author(s)
      永次 史
    • Organizer
      有機合成夏季セミナー 明日の有機合成化学
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] Development of the effective alkylating probes for the higher-ordered structure of nucleic acids, Development of the effective alkylating probes for G-Quadruplex2019

    • Author(s)
      K.Onizuka, M.E. Hazemi, N. Sato, G. Tsuji, S. Ishikawa, F.Nagatsugi
    • Organizer
      27th FJS Symposium
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Development of the alkylation reactions to the higher-ordered structures of nucleic acids2019

    • Author(s)
      K.Onizuka, M.E. Hazemi, N. Sato, G. Tsuji , S. Ishikawa, F. Nagatsugi
    • Organizer
      CISNAC 2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Base flip-inducing oligo DNA and photo-crosslinking2019

    • Author(s)
      K.Onizuka, K. Ishida, E. Mano, F. Nagatsugi,
    • Organizer
      CISNAC 2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Development of the functional molecules for alkylating G-quadruplex2019

    • Author(s)
      S. Ishikawa, M. E. Hazemi, K.Onizuka, F.Nagatsugi
    • Organizer
      Tohoku University Campus Asia Program Summer School 2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Base-flip-inducing oligo DNA and photo-crosslinking on the flipping-out field2019

    • Author(s)
      K. Onizuka, K. Ishida, S. Yajima, E. Mano, F. Nagatsugi
    • Organizer
      ISNAC 2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Orthogonal base pair formation by nucleoside analogs bearing additional hydrogen-bonding units2019

    • Author(s)
      H. Okamura, G. H. Trinh, F. Nagatsugi
    • Organizer
      ISNAC 2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 遺伝子発現を制御する機能性中分子の創製2019

    • Author(s)
      永次 史
    • Organizer
      新学術領域成果報告会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 反応性OFF-ON型核酸高次構造選択的アルキル化剤の開発2019

    • Author(s)
      鬼塚和光、Madoka E. Hazemi、石川竣也、永次 史
    • Organizer
      第115回有機合成化学シンポジウム
    • Related Report
      2019 Annual Research Report
  • [Presentation] 核酸高次構造選択的アルキル化のための反応性OFF-ON型反応素子の開発2019

    • Author(s)
      鬼塚和光、Madoka E. Hazemi、石川竣也、永次 史
    • Organizer
      日本ケミカルバイオロジー学会 第14回年会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 核酸高次構造選択的アルキル化反応は遺伝子発現を制御する2019

    • Author(s)
      鬼塚和光、ハゼミ・マドカ、石川俊也、永次 史、
    • Organizer
      第22回生命化学研究会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 効率的遺伝子制御を目指した配座固定型架橋反応性オリゴヌクレオチドの開発2019

    • Author(s)
      8.永次 史、福間清乃、阿部友亮、山田 研、村瀬裕貴、岡村秀紀
    • Organizer
      第5回日本核酸医薬学会年会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 核酸塩基フリップアウト場における特異な光反応2019

    • Author(s)
      鬼塚 和光、石田 圭、間野 江梨子、永次 史
    • Organizer
      第13回バイオ関連化学シンポジウム
    • Related Report
      2019 Annual Research Report
  • [Presentation] 付加的な水素結合ユニットを有するデュアルヘッド型人工塩基対の開発2019

    • Author(s)
      岡村秀紀、Trinh Hoang Giang、永次 史
    • Organizer
      第13回バイオ関連化学シンポジウム
    • Related Report
      2019 Annual Research Report
  • [Presentation] 高機能化遺伝子発現システムの構築を指向した新規人工塩基対の創製2019

    • Author(s)
      岡村秀紀、Trinh Hoang Giang、永次 史
    • Organizer
      第19回多元物質科学研究所研究発表会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Light-up型蛍光小分子に結合する核酸配列の最適化技術の確立と応用2019

    • Author(s)
      遠藤玉樹、村瀬裕貴、鬼塚和光、永次 史、杉本直己
    • Organizer
      第19回多元物質科学研究所研究発表会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Selective Binding Molecules to Nucleic Acids in the Higher-Ordered Structures2019

    • Author(s)
      Fumi Nagatsugi, Hirotaka Murase, Kazumitsu Onizuka
    • Organizer
      Asian Chemical Biology Initiative 2019
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] G4重鎖をアルキル化する機能性分子の開発2019

    • Author(s)
      石川俊也、Hazemi Eurika Madoka、鬼塚和光、永次 史
    • Organizer
      日本化学会第99春季年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 標的核酸塩基のフリップアウトを誘起する人工核酸の開発と特異な光反応2019

    • Author(s)
      鬼塚 和光、石田 圭、間野絵梨子、永次 史
    • Organizer
      日本化学会第99春季年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] G-clampによるグアニン認識を基本としたRNA高次構造結合性低分子リガンドの開発2019

    • Author(s)
      村瀬裕貴、永次 史
    • Organizer
      日本薬学会第139年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Selective Binding Molecules to Nucleic Acids in the Higher-Ordered Structures2018

    • Author(s)
      Fumi Nagatsugi, HAZEMI, Madoka Eurika, Akira Usami, Norihiro Sato, Kazumitsu Onizuka
    • Organizer
      The 3rd A3 Roundtable Meeting on Chemical Probe Research Hub
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 疾患関連核酸高次構造を標的とした反応性プローブの開発2018

    • Author(s)
      永次 史
    • Organizer
      平成30年度化学系学協会東北大会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Development of the effective alkylating probes for G-Quadruplex2018

    • Author(s)
      Fumi Nagatsugi, Norihiro Sato, Madoka Hazemi Eurika,Kazumitsu Onizuka
    • Organizer
      XXIII Round Table on Nucleosides, Nucleotides and Nucleic Acids Chemical Biology of Nucleic Acids
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Development of fluorescent probe for RNA higher-order structure2018

    • Author(s)
      Hirotaka Murase, Fumi Nagatsugi
    • Organizer
      XXIII Round Table on Nucleosides, Nucleotides and Nucleic Acids Chemical Biology of Nucleic Acids
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Spontaneous pseudorotaxane formation targeting nucleic acids2018

    • Author(s)
      Kazumitsu Onizuka, Jumpei Matsuyama Takuya Miyashita, Yuuya Kawasaki, Kazunobu Igawa, Katsuhiko Tomooka, Fumi Nagatsugi
    • Organizer
      XXIII Round Table on Nucleosides, Nucleotides and Nucleic Acids Chemical Biology of Nucleic Acids
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Development of fluorescence OFF/ON type pseudorotaxane-forming nucleic acids for noncovalent labeling of RNA2018

    • Author(s)
      Jumpei Matsuyama, Kazumitsu Onizuka, Takuya Miyashita, Yuuya Kawasaki, Kazunobu Igawa, Katsuhiko Tomooka, Fumi Nagatsugi
    • Organizer
      Tohoku University Campus Asia Program Summer School 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Development of the acyclic linked 7-deaza-6-vinyl guanine derivatives and Evaluation of the crosslinking reactivity2018

    • Author(s)
      Kiyono Fukuma, Hirotaka Murase, Yusuke Abe, Ken Yamada, Kazumitsu Onizuka, Fumi Nagatsugi
    • Organizer
      Tohoku University Campus Asia Program Summer School 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Development of artificial nucleic acids to induce the base flipping out2018

    • Author(s)
      Kei Ishida, Kazumitsu Onizuka, and Fumi Nagatsugi
    • Organizer
      Tohoku University Campus Asia Program Summer School 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Synthesis of a new reactive base targeting for RNA binding proteins2018

    • Author(s)
      Sato Misaki, Hirotaka Murase, Takuya Akisawa, Fumi Nagatsug
    • Organizer
      Tohoku University Campus Asia Program Summer School 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Targeting RNA G-Quadruplex and KRas Protein-Protein Interaction Using Click chemistry2018

    • Author(s)
      Toan Khanh Le, Kazumitsu Onizuka, Junko Ohkanda, Fumi Nagatsugi
    • Organizer
      Tohoku University Campus Asia Program Summer School 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Synthesis of biotinylated nucleic acids binding molecules for the analysis of their binding RNA sequences2018

    • Author(s)
      Kanna Ojima, Kazumitsu Onizuka, Kousuke Tanno, Fumi Nagatsugi
    • Organizer
      Tohoku University Campus Asia Program Summer School 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Development of small molecular G-clamp derivatives binding to RNA higher-order structure2018

    • Author(s)
      Hirotaka Murase, Fumi Nagatsugi
    • Organizer
      The 45th International Symposium on Nucleic Acids Chemistry
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Spontaneous pseudorotaxane formation targeting nucleic acids and fluorogenic click chemistry2018

    • Author(s)
      K.Onizuka, J. Matsuyama, T.Miyashita, Y. Kawasaki, K. Igawa, K.Tomooka, F. Nagatsugi
    • Organizer
      The 45th International Symposium on Nucleic Acids Chemistry
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Development of the Cross-linkable Oligonucleotides for the Control of Gene Expression2018

    • Author(s)
      Fumi Nagatsugi, Ken Yamada, Yusuke Abe, Kiyono Fukuma, Hirotaka Murase
    • Organizer
      IKCOC-14
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 1,3-ジアザフェノキサジン環によるグアニン認識を利用したRNA高次構造検出プローブの開発2018

    • Author(s)
      村瀬裕貴、永次 史
    • Organizer
      日本ケミカルバイオロジー学会 第13回年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] ビオチンを修飾した核酸結合性分子の合成と結合RNA配列解析への展開2018

    • Author(s)
      小嶋かんな、鬼塚和光、丹野宏亮、永次 史
    • Organizer
      日本ケミカルバイオロジー学会 第13回年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 擬ロタキサン形成核酸の開発とその応用研究2018

    • Author(s)
      鬼塚 和光、松山 潤炳、宮下 卓也、河崎 悠也、井川 和宣、友岡 克彦、永次 史
    • Organizer
      第4回日本核酸医薬学会年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 効率的遺伝子制御に向けた架橋反応性7-デアザ-6-ビニルグアニン誘導体の開発2018

    • Author(s)
      村瀬裕貴、福間清乃、阿部友亮、山田研、鬼塚和光、永次 史
    • Organizer
      第4回日本核酸医薬学会年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 核酸高次構造アルキル化のための新規反応剤の開発2018

    • Author(s)
      鬼塚 和光、Hazemi E.Madoka, 丹野宏亮、石川俊也、佐藤憲大、永次 史
    • Organizer
      第12回バイオ関連化学シンポジウム
    • Related Report
      2018 Annual Research Report
  • [Presentation] 標的核酸塩基をフリップアウトさせる機能性核酸の開発2018

    • Author(s)
      石田 圭、鬼塚 和光、永次 史
    • Organizer
      第12回バイオ関連化学シンポジウム
    • Related Report
      2018 Annual Research Report
  • [Presentation] フリップアウト能を持つ人工核酸の開発と特異な化学反応の検討2018

    • Author(s)
      石田 圭、鬼塚 和光、間野絵梨子、永次 史
    • Organizer
      第18回多元物質科学研究所研究発表会
    • Related Report
      2018 Annual Research Report
  • [Presentation] RNAの非共有結合性蛍光ラベル化を可能にする蛍光ON型擬ロタキサン形成核酸の開発2018

    • Author(s)
      鬼塚和光、松山潤平、小澤眞美子、宮下卓也、河崎悠也、井川和亘、友岡克彦、吉田優、細谷孝充、永次 史
    • Organizer
      第18回多元物質科学研究所研究発表会
    • Related Report
      2018 Annual Research Report
  • [Presentation] RNA切断能を持つ機能性核酸の開発2018

    • Author(s)
      鬼塚 和光・田口 晃史・永次 史
    • Organizer
      日本化学会第98春季年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] RNAの非共有結合性蛍光ラベル化を可能にする蛍光OFF/ON型擬ロタキサン形成核酸の開発2018

    • Author(s)
      松山 潤炳1・鬼塚 和光・宮下 卓也・河崎 悠也・井川 和宣・友岡 克彦・永次 史
    • Organizer
      日本化学会第98春季年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 相補塩基のフリップアウトを誘起する人工核酸の開発2018

    • Author(s)
      石田 圭・鬼塚 和光・永次 史
    • Organizer
      日本化学会第98春季年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] ビオチンをコンジュゲートした核酸結合性小分子の合成と結合RNA配列解析への展開2018

    • Author(s)
      小嶋 かんな・鬼塚 和光・丹野 宏亮・永次 史
    • Organizer
      日本化学会第98春季年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 高い架橋反応性を持つ7-デアザ-6-ビニルグアニン誘導体の開発2018

    • Author(s)
      福間 清乃 ・ 阿部 友亮 ・ 山田 研 ・鬼塚 和光・ 村瀬 裕貴・ 永次 史
    • Organizer
      日本薬学会第138年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 標的RNAを化学的に切断する機能性核酸の開発2018

    • Author(s)
      鬼塚 和光 ・ 田口 晃史 ・ 永次 史
    • Organizer
      日本薬学会第138年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] ヘアピンRNAに結合する1,3-ジアザフェノキサジン誘導体の開発2018

    • Author(s)
      村瀬 裕貴 ・ 永次 史
    • Organizer
      日本薬学会第138年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] ビニルキナゾリノン誘導体によるG-四重鎖構造のアルキル化2018

    • Author(s)
      Madoka Eurika HAZEMI・ Kazumitsu ONIZUKA・Norihiro SATO ・Fumi NAGATSUGI
    • Organizer
      日本薬学会第138年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 核酸高次構造をアルキル化する中分子の開発2017

    • Author(s)
      永次 史
    • Organizer
      日本薬学会第137年会(仙台)
    • Place of Presentation
      仙台国際センター(宮城県仙台市)
    • Year and Date
      2017-03-24
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 環状化核酸を用いたスリッピングによる擬ロタキサン構造形成のメカニズム研究2017

    • Author(s)
      鬼塚和光、千国友子、宮下卓也、永次 史
    • Organizer
      日本薬学会第137年会(仙台)
    • Place of Presentation
      東北大学川内キャンパス(宮城県仙台市)
    • Year and Date
      2017-03-24
    • Related Report
      2016 Annual Research Report
  • [Presentation] 脱塩基部位を持つ2本鎖DNAを標的とした効率的アルキル化プローブの開発2017

    • Author(s)
      丹野 宏亮・山田 研・佐々木 欣宏・佐藤 憲大・鬼塚 和光・永次 史
    • Organizer
      日本化学会第97春季年会
    • Place of Presentation
      慶應義塾大学 日吉キャンパス(神奈川県横浜市)
    • Year and Date
      2017-03-14
    • Related Report
      2016 Annual Research Report
  • [Presentation] Mechanistic study of pseudorotaxane formation via the slipping process targeting on nucleic acids2017

    • Author(s)
      ONIZUKA, Kazumitsu; CHIKUNI, Tomoko; MIYASHITA, Takuya; NAGATSUGI, Fumi
    • Organizer
      日本化学会第97春季年会
    • Place of Presentation
      慶應義塾大学 日吉キャンパス(神奈川県横浜市)
    • Year and Date
      2017-03-14
    • Related Report
      2016 Annual Research Report
  • [Presentation] Investigation of linker structures to functionalize pseudorotaxane-forming oligo nucleic acids2017

    • Author(s)
      TAGUCHI, Akifumi; ONIDUKA, Kazumitu; MIYASHITA, Takuya; NAGATSUGI, Fumi
    • Organizer
      日本化学会第97春季年会
    • Place of Presentation
      慶應義塾大学 日吉キャンパス(神奈川県横浜市)
    • Year and Date
      2017-03-14
    • Related Report
      2016 Annual Research Report
  • [Presentation] Selective G-quadruplex alkylation by vinyl triazine derivatives2017

    • Author(s)
      HAZEMI, Madoka Eurika; USAMI, Akira; KOBAYASHI, Tomohito; SATO, Norihiro; ONIZUKA, Kazumitsu; NAGATSUGI, Fumi
    • Organizer
      日本化学会第97春季年会
    • Place of Presentation
      慶應義塾大学 日吉キャンパス(神奈川県横浜市)
    • Year and Date
      2017-03-14
    • Related Report
      2016 Annual Research Report
  • [Presentation] Development of the Chemical Tools for the Alkylation to Nucleic Acid Binding Protein2017

    • Author(s)
      F. Nagatsugi, K. Odaira, K. Yamada
    • Organizer
      Asian Chemical Biology Initiative (ACBI) 2017
    • Place of Presentation
      Ho-chi-minh, Vietnam
    • Year and Date
      2017-01-20
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] トリアジン型シクロファンの開発と分子認識2017

    • Author(s)
      草野修平、小西紗枝、永次 史、林田 修
    • Organizer
      第17回多元物質科学研究所研究発表会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 動的分子認識を指向した蛍光性ベンゾオキサボロールの合成及びcis-1,2ジオール認識能評価2017

    • Author(s)
      小西紗枝、永次 史、林田 修、草野修平
    • Organizer
      第17回多元物質科学研究所研究発表会
    • Related Report
      2017 Annual Research Report
  • [Presentation] RNAの非共有結合性蛍光ラベル化を可能にする蛍光ON型擬ロタキサン形成核酸の開発2017

    • Author(s)
      松山潤平、鬼塚和光、宮下卓也、河崎悠也、井川和宣、友岡克彦、永次 史
    • Organizer
      第17回多元物質科学研究所研究発表会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Spontaneous pseudorotaxane formation targeting RNA2017

    • Author(s)
      K. Onizuka, J. Matsuyama, T. Miyashita, Y. Kawasaki, K. Igawa, K. Tomooka, F. Nagatsugi
    • Organizer
      ISBC2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] The development of small molecules binding to the hairpin RNA structur2017

    • Author(s)
      H. Murase, F.Nagatsugi
    • Organizer
      ISBC2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Development of novel G-quadruplex alkylating agents2017

    • Author(s)
      M. E. Hazemi, K. Onizuka, T. Kobayashi, A. Usami, N. Sato, F. Nagatsugi
    • Organizer
      ISBC2017
    • Related Report
      2017 Annual Research Report
  • [Presentation] Selective alkylation of T-T mismatched bases in DNA2017

    • Author(s)
      K. Onizuka, A. Usami, Y. Yamaoki, T. Kobayashi, M. E. Hazemi, T. Chikuni, M. Katahira, F. Nagatsug
    • Organizer
      The 44th International Symposium on Nucleic Acids Chemistry
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Development of G-quadruplex Alkylating Small Molecules2017

    • Author(s)
      M. E. Hazemi, K. Onizuka, T. Kobayashi, A. Usami, N. Sato, F. Nagatsugi
    • Organizer
      The 44th International Symposium on Nucleic Acids Chemistry
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 核酸高次構造をアルキル化する中分子の開発2017

    • Author(s)
      永次 史
    • Organizer
      アライアンス医療材料・デバイス・システムグループG3 分科会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 高効率遺伝子発現制御を指向した、架橋反応性7-デアザ-6-ビニルグアニン誘導体の開発2017

    • Author(s)
      福間清乃、阿部友亮、山田研、鬼塚和光、村瀬裕貴、永次 史
    • Organizer
      第11回バイオ関連化学シンポジウム
    • Related Report
      2017 Annual Research Report
  • [Presentation] DNA中のT-Tミスマッチ構造を選択的にアルキル化する小分子の開発2017

    • Author(s)
      鬼塚 和光、宇佐美 彬、山置佑大、小林倫仁、Madoka Eurika Hazemi、千国友子、片平 正人、永次 史
    • Organizer
      第11回バイオ関連化学シンポジウム
    • Related Report
      2017 Annual Research Report
  • [Presentation] Development of the Reactive Oligonucleotides for the Control of Gene Expression2017

    • Author(s)
      F. Nagatsugi, K. Yamada, Y. Abe, S. Kusano
    • Organizer
      26th FJS symposium
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Development of the Reactive Probes for Selective Alkylation to G4 Structure2017

    • Author(s)
      F. Nagatsugi
    • Organizer
      Asian Chemical Biology Initiative
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 核酸高次構造をアルキル化する中分子の開発~生体分子に対する選択的化学反応の開発~2017

    • Author(s)
      永次 史
    • Organizer
      第4回 新学術領域研究 反応集積化が導く中分子戦略:高次生物機能分子の創製、若手シンポジウム
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Development of artificial oligonucleotides with the RNA- cleaving ability2017

    • Author(s)
      A. Taguchi, K. Onizuka, F. Nagatsugi
    • Organizer
      Tohoku University Campus Asia Program Summer School 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Development of new efficient alkylating probes targeting double stranded DNA containing an abasic-site2017

    • Author(s)
      K. Tanno, K. Yamada, Y. Sasaki, N. Sato, K. Onizuka F. Nagatsugi
    • Organizer
      Tohoku University Campus Asia Program Summer School 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 遺伝子発現を制御する機能性中分子の創製2017

    • Author(s)
      永次 史
    • Organizer
      第4回 新学術領域研究 反応集積化が導く中分子戦略:高次生物機能分子の創製 成果報告会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 効率的遺伝子発現制御を目指した核酸をテンプレートにした選択的化学反応の開発2017

    • Author(s)
      永次 史
    • Organizer
      第29回万有札幌シンポジウム
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 核酸結合蛋白質に対する新規架橋反応性核酸の開発2017

    • Author(s)
      永次 史,小平 健太, 山田 研
    • Organizer
      第3回日本核酸医薬学会年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Spontaneous pseudorotaxane formation methods targeting on RNA2017

    • Author(s)
      K. Onizuka, T. Miyashita, T. Chikuni, F. Nagatsugi
    • Organizer
      The 43rd Naito conference on noncoding RNA: biology, chemistry, and diseases
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] T-Tミスマッチ構造を選択的にアルキル化する小分子の開発2017

    • Author(s)
      鬼塚 和光、宇佐美 彬、小林倫仁、Madoka Eurika Hazemi、永次 史
    • Organizer
      日本ケミカルバイオロジー学会 第12回年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 核酸医薬の修飾技術動向2017

    • Author(s)
      永次 史
    • Organizer
      技術情報協会セミナー
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Development of the Chemical Tools for the Alkylation to Nucleic Acid Binding Protein2016

    • Author(s)
      F. Nagatsugi, K. Odaira, K. Yamada
    • Organizer
      The Fourth Asian Chemical Biology Conference (ACBC2016)
    • Place of Presentation
      85 Sky Tower Hotel, Kaohsiung, TAIWAN
    • Year and Date
      2016-11-28
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Synthesis of Middle Molecular Probes for theSelective Chemical Modification to Higher-Order Structures in RNA2016

    • Author(s)
      A. Usami, T. Kobayashi, M. E. Hazemi, N. Sato, K. Onizuka, F. Nagatsugi
    • Organizer
      ISONIS 10
    • Place of Presentation
      Awajishima Hyogo,Yumebutai, International Conference center
    • Year and Date
      2016-11-18
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 翻訳制御を指向した擬ロタキサン形成オリゴ核酸の開発2016

    • Author(s)
      鬼塚 和光、宮下 卓也、永次 史
    • Organizer
      第2回日本核酸医薬学会年会
    • Place of Presentation
      東京理科大学葛飾キャンパス図書館(東京都葛飾区)大ホール
    • Year and Date
      2016-11-15
    • Related Report
      2016 Annual Research Report
  • [Presentation] Structural optimization of pseudorotaxane-forming oligoDNA targeting on nucleic acids2016

    • Author(s)
      K. Onizuka, Miyashita, T., F. Nagatsugi
    • Organizer
      The 43th International Symposium on Nucleic Acids Chemistry
    • Place of Presentation
      Kumamoto Univ., Kumamoto, Japan
    • Year and Date
      2016-09-27
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Synthesis of natural-like cross-linked duplex RNA and its properties2016

    • Author(s)
      M.E. Hazemi, K. Onizuka, K. Yamada, F. Nagatsugi
    • Organizer
      The 43th International Symposium on Nucleic Acids Chemistry
    • Place of Presentation
      Kumamoto Univ., Kumamoto, Japan
    • Year and Date
      2016-09-27
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Preparation of “Cross-Linkable duplex” using the Oligonucleotide Containing 4-amino-2-oxo-6-vinyl-1,3,5-triazine2016

    • Author(s)
      F. Nagatsugi, K. Odaira, K. Yamada
    • Organizer
      The First A3 Roundtable Meeting on Chemical Probe Research Hub
    • Place of Presentation
      Hotel LEOPALACE Hakata, Fukuoka Japan
    • Year and Date
      2016-09-22
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 標的核酸に対して自発的に擬ロタキサン構造を形成する人工核酸の開発2016

    • Author(s)
      鬼塚 和光、宮下 卓也、永次 史
    • Organizer
      第10回バイオ関連化学シンポジウム
    • Place of Presentation
      石川県立音楽堂もてなしドーム(石川県金沢市)
    • Year and Date
      2016-09-07
    • Related Report
      2016 Annual Research Report
  • [Presentation] U-Uミスマッチ構造選択的な化学修飾を目指した中分しプローブの開発2016

    • Author(s)
      宇佐美 彬、小林 倫仁、Hazemi Eurika Madoka、鬼塚 和光、永次 史
    • Organizer
      第10回バイオ関連化学シンポジウム
    • Place of Presentation
      石川県立音楽堂もてなしドーム(石川県金沢市)
    • Year and Date
      2016-09-07
    • Related Report
      2016 Annual Research Report
  • [Presentation] Development of Middle Molecular Probes for the Selective Chemical Modification to Higher-Order Structures in RNA2016

    • Author(s)
      A. Usami, T. Kobayashi, M. E. Hazemi, N. Sato, K. Onizuka, F. Nagatsugi
    • Organizer
      Tohoku University Campus Asia Program Summer School
    • Place of Presentation
      Tohoku Univ. Sendai, Japan
    • Year and Date
      2016-08-17
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Deveropment of psedorotaxane-forming oligonucleotides aiming at translational regulation2016

    • Author(s)
      T. Miyashita, K. Onizuka, F. Nagatsugi
    • Organizer
      Tohoku University Campus Asia Program Summer School
    • Place of Presentation
      Tohoku Univ. Sendai, Japan
    • Year and Date
      2016-08-17
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Synthesis of a new cross-linkable nucleic acid derivative targeting nucleic acid binding protein2016

    • Author(s)
      K. Odaira, S. Ishiyama, K. Yamada, F. Nagatsugi
    • Organizer
      Tohoku University Campus Asia Program Summer School
    • Place of Presentation
      Tohoku Univ. Sendai, Japan
    • Year and Date
      2016-08-17
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Synthesis of Natural-like Cross-linked duplex RNA for Biochemical Studies2016

    • Author(s)
      M. H. Eurika, K. Onizuka, K. Yamada, F. Nagatsugi
    • Organizer
      Tohoku University Campus Asia Program Summer School
    • Place of Presentation
      Tohoku Univ. Sendai, Japan
    • Year and Date
      2016-08-17
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Synthesis of the middle-size molecules for alkylation to highly ordered structures of nucleic acids2016

    • Author(s)
      N. Sato, Y. Sasaki, G.Tsuji, A.Usami, K. Onizuka, K.Yamada and F. Nagatsugi
    • Organizer
      XXII Round Table on Nucleosides, Nucleotides and Nucleic Acids Chemical Biology of Nucleic Acids
    • Place of Presentation
      Paris, France
    • Year and Date
      2016-07-16
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Synthesis of a New Cross-Linkable Oligonucleotides having 4-Amino-6-Oxo-2-Vinyl-Triazine2016

    • Author(s)
      K. Yamada, K. Odaira, S. Ishiyama, F. Nagatsugi
    • Organizer
      XXII Round Table on Nucleosides, Nucleotides and Nucleic Acids Chemical Biology of Nucleic Acids
    • Place of Presentation
      Paris, France
    • Year and Date
      2016-07-16
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 核酸結合性蛋白質との架橋反応を目指したビニルトリアジン誘導体の開発2016

    • Author(s)
      山田 研、小平 健太、石山 翔午、鬼塚和光、永次 史
    • Organizer
      日本ケミカルバイオロジー学会 第11回年会
    • Place of Presentation
      京都テルサ(京都府京都市)
    • Year and Date
      2016-06-10
    • Related Report
      2016 Annual Research Report
  • [Presentation] DNA/RNAを標的とした擬ロタキサン形成オリゴDNAの構造最適化2016

    • Author(s)
      宮下 卓也、鬼塚 和光、永次 史
    • Organizer
      日本ケミカルバイオロジー学会 第11回年会
    • Place of Presentation
      京都テルサ(京都府京都市)
    • Year and Date
      2016-06-10
    • Related Report
      2016 Annual Research Report
  • [Presentation] Selective Reactions to Nucleic Acids with Higher Ordered Structure2016

    • Author(s)
      F. Nagatsugi, N. Sato, Kobayashi, Y. Sasaki, K.Onizuka, K. Yamada
    • Organizer
      12 th International, Symposium on Organic Reactions
    • Place of Presentation
      Kyoto Terrsa, Kyoto, Japan
    • Year and Date
      2016-04-21
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 核酸を標的とした擬ロタキサン形成オリゴ核酸の構造最適化2016

    • Author(s)
      鬼塚和光、宮下卓也、雨宮拓哉、永次 史
    • Organizer
      日本薬学会136年会
    • Place of Presentation
      パシフィコ横浜、神奈川
    • Year and Date
      2016-03-26
    • Related Report
      2015 Annual Research Report
  • [Presentation] 核酸結合性蛋白質を標的とした新規架橋反応性核酸誘導体の合成2016

    • Author(s)
      小平健太、石山 翔午、山田 研、永次 史
    • Organizer
      日本化学会第96春季年会
    • Place of Presentation
      同志社大学、京都
    • Year and Date
      2016-03-24
    • Related Report
      2015 Annual Research Report
  • [Presentation] 核酸標的擬ロタキサン形成オリゴDNAの構造最適化2016

    • Author(s)
      宮下卓也、鬼塚和光、永次 史
    • Organizer
      日本化学会第96春季年会
    • Place of Presentation
      同志社大学、京都
    • Year and Date
      2016-03-24
    • Related Report
      2015 Annual Research Report
  • [Presentation] U-Uミスマッチ構造を選択的に化学修飾する小分子プローブの開発2016

    • Author(s)
      宇佐美 彬、小林倫仁、佐藤憲大、鬼塚和光、永次 史
    • Organizer
      日本化学会第96春季年会
    • Place of Presentation
      同志社大学、京都
    • Year and Date
      2016-03-24
    • Related Report
      2015 Annual Research Report
  • [Presentation] Development of the New Probes for the Selective Chemical Modification to Higher Ordered Structured Nucleic Acids2016

    • Author(s)
      Fumi Nagatsugi
    • Organizer
      Asian Chemical Biology Initiative 2016
    • Place of Presentation
      Jakarta, Indonesia
    • Year and Date
      2016-01-30
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 核酸結合性タンパク質を標的とした新規架橋反応性塩基の合成と評価2016

    • Author(s)
      小平 健太、石山 翔午、山田 研、永次 史
    • Organizer
      第27回万有シンポジウム
    • Place of Presentation
      仙台国際センター(宮城県仙台市)
    • Related Report
      2016 Annual Research Report
  • [Presentation] 脱塩基部位を持つ2本鎖DNA選択的アルキル化プローブの開発2016

    • Author(s)
      丹野宏亮、山田 研、佐々木欣宏、佐藤憲大、永次 史
    • Organizer
      第16回多元物質科学研究所研究発表会
    • Place of Presentation
      東北大学片平キャンパス・さくらホール(宮城県仙台市)
    • Related Report
      2016 Annual Research Report
  • [Presentation] Development of the Middle-size Molecules for Alkylation to Highly Ordered Structures of Nucleic Acids2016

    • Author(s)
      F. Nagatsugi
    • Organizer
      The 2nd International Symposium on Middle Molecular Strategy
    • Place of Presentation
      Senri Life Science Center, Osaka, Japan
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] RNAを標的とした擬ロタキサン形成オリゴDNAの構造最適化2015

    • Author(s)
      宮下 卓也, 鬼塚 和光, 永次 史
    • Organizer
      第15回多元物質科学研究所研究発表会
    • Place of Presentation
      東北大学片平キャンパス・さくらホール、仙台
    • Year and Date
      2015-12-22
    • Related Report
      2015 Annual Research Report
  • [Presentation] Development of pseudorotaxane formation methods targeting on nucleic acids2015

    • Author(s)
      Kazumitsu Onizuka, Yoshihiro Ito, Hiroshi Abe, Fumi Nagatsugi
    • Organizer
      Pacifichem 2015
    • Place of Presentation
      Hawaii, USA.
    • Year and Date
      2015-12-15
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Development of the strategy for the selective chemical modification in a hydrophobic site in DNA or RNA2015

    • Author(s)
      Norihiro Sato, Tomohito Kobayashi, Yoshihiro Sasaki, Kazumitsu Onizuka, Ken Yamada, Fumi Nagatsugi
    • Organizer
      Pacifichem 2015
    • Place of Presentation
      Hawaii, USA.
    • Year and Date
      2015-12-15
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 架橋反応性塩基を持つ擬相補的PNAの合成と2本鎖DNAに対する反応性評価2015

    • Author(s)
      永次 史,秋澤拓也
    • Organizer
      第1回日本核酸医薬学会年会
    • Place of Presentation
      京都テルサ、京都
    • Year and Date
      2015-11-30
    • Related Report
      2015 Annual Research Report
  • [Presentation] Development of the crosslinking reactions to RNA for application in cells2015

    • Author(s)
      Fumi Nagatsugi
    • Organizer
      Pharmaceutical Science Symposium
    • Place of Presentation
      Sakura hall, Sendai, Japan
    • Year and Date
      2015-10-16
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Development of the Effective Chemical Strategy for Regulation of Gene Expression.2015

    • Author(s)
      Nagatsugi F., Hagihara S., Kusano S
    • Organizer
      Pharmaceutical Science Symposium 2015
    • Place of Presentation
      Sakura hall, Sendai, Japan
    • Year and Date
      2015-10-16
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 核酸結合性タンパク質との架橋反応を目指したビニルトリアジン誘導体の合成2015

    • Author(s)
      小平健太、石山翔午、山田研、 鬼塚和光、永次史
    • Organizer
      第4回CSJ化学フェスタ2015
    • Place of Presentation
      タワーホール船堀、東京
    • Year and Date
      2015-10-14
    • Related Report
      2015 Annual Research Report
  • [Presentation] The effect of intra-strand cross-link formation on the stability of DNA i-motif2015

    • Author(s)
      Kenji Kikuta, Piao Haishun, John Brazir, Kazumitsu Onizuka, Fumi Nagatsugi, Yosuke Taniguchi, Shigeki Sasaki
    • Organizer
      The 42th International Symposium on Nucleic Acids Chemistry
    • Place of Presentation
      Egret Himeji, Himeji Japan
    • Year and Date
      2015-09-23
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Pseudorotaxane formation via slipping process targeting on nucleic acids2015

    • Author(s)
      Kazumitsu Onizuka, Takuya Miyashita , Fumi Nagatsugi
    • Organizer
      The 42th International Symposium on Nucleic Acids Chemistry
    • Place of Presentation
      Egret Himeji, Himeji Japan
    • Year and Date
      2015-09-23
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Development of the selective crosslinking reactions to 8-oxoguanine2015

    • Author(s)
      Fumi Nagatsugi, Shuhei Kusano, Shogo Ishiyama, Sik Lok Lam, Tsukasa Mashima, Masato Katahira, Fumi Nagatsugi
    • Organizer
      The 42th International Symposium on Nucleic Acids Chemistry
    • Place of Presentation
      Egret Himeji, Himeji Japan
    • Year and Date
      2015-09-23
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 効率的遺伝子発現制御を目指した選択的化学反応の開発2015

    • Author(s)
      永次 史
    • Organizer
      第32回有機合成セミナ
    • Place of Presentation
      ニューウェルシティ湯河原 湯河原, 神奈川県
    • Year and Date
      2015-09-15
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] DNA高次構造選択的にアルキル化する小分子の開発2015

    • Author(s)
      佐々木欣宏、佐藤憲大、辻厳一郎、山田 研、永次 史、佐藤 憲大、辻 厳一郎、茂木 琢真、鬼塚 和光、永次 史、、
    • Organizer
      第9回バイオ関連化学シンポジウム
    • Place of Presentation
      熊本大学工学部、熊本
    • Year and Date
      2015-09-10
    • Related Report
      2015 Annual Research Report
  • [Presentation] 生化学ツールのための架橋形成した天然擬似2本鎖RNAの合成2015

    • Author(s)
      鬼塚和光、Hazemi Madoka Eurika、永次 史
    • Organizer
      第9回バイオ関連化学シンポジウム
    • Place of Presentation
      熊本大学工学部、熊本
    • Year and Date
      2015-09-10
    • Related Report
      2015 Annual Research Report
  • [Presentation] 核酸を標的とした擬ロタキサン形成オリゴDNAの構造最適化2015

    • Author(s)
      宮下 卓也、鬼塚和光、永次 史、
    • Organizer
      第9回バイオ関連化学シンポジウム
    • Place of Presentation
      熊本大学工学部、熊本
    • Year and Date
      2015-09-10
    • Related Report
      2015 Annual Research Report
  • [Presentation] 鎖内クロスリンク形成によるi-motifの安定化2015

    • Author(s)
      菊田健司、朴 海順、John Brazier、鬼塚和光、永次 史、谷口陽祐、佐々木茂貴、
    • Organizer
      第9回バイオ関連化学シンポジウム
    • Place of Presentation
      熊本大学工学部、熊本
    • Year and Date
      2015-09-10
    • Related Report
      2015 Annual Research Report
  • [Presentation] RNAを高次構造選択的に化学修飾する小分子プローブの開発2015

    • Author(s)
      宇佐美 彬、佐藤憲大、鬼塚和光、永次 史、
    • Organizer
      第9回バイオ関連化学シンポジウム
    • Place of Presentation
      熊本大学工学部、熊本
    • Year and Date
      2015-09-10
    • Related Report
      2015 Annual Research Report
  • [Presentation] 核酸結合性蛋白質との反応を目指したビニルトリアジンを有する核酸誘導体の開発2015

    • Author(s)
      山田 研、石山 翔午、鬼塚 和光、永次 史
    • Organizer
      第9回バイオ関連化学シンポジウム
    • Place of Presentation
      熊本大学工学部、熊本
    • Year and Date
      2015-09-10
    • Related Report
      2015 Annual Research Report
  • [Presentation] Synthesis and Evaluation of the Reactivity of 7-Deaza-6-vinylguanosine Derivatives2015

    • Author(s)
      Yusuke Abe, Ken Yamada, Yuta Ida, and Fumi Nagatsugi
    • Organizer
      Tohoku University Campus Asia Program Summer School
    • Place of Presentation
      Tohoku University,Sendai, Japan
    • Year and Date
      2015-08-28
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Synthesis of vinyltriazine derivatives aiming at alkylation to U‒U mismatch structure in RNA2015

    • Author(s)
      Tomohito Kobayashi, Kazumitsu Onizuka, Fumi Nagatsugi
    • Organizer
      Tohoku University Campus Asia Program Summer School
    • Place of Presentation
      Tohoku University, Sendai, Japan
    • Year and Date
      2015-08-28
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Development of small molecular probes for selective alkylation of the higher-order structure of nucleic acid2015

    • Author(s)
      Yoshihiro Sasaki, Norihiro Sato, Genichiro Tsuji, Ken Yamada, Fumi Nagatsugi, s
    • Organizer
      Tohoku University Campus Asia Program Summer School
    • Place of Presentation
      Tohoku University, Sendai, Japan
    • Year and Date
      2015-08-28
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Development of the interlocked structure formation method targeted RNA2015

    • Author(s)
      Takuya Amemiya, Kazumitsu Onizuka, Fumi Nagatsugi
    • Organizer
      Tohoku University Campus Asia Program Summer School
    • Place of Presentation
      Tohoku University, Sendai, Japan
    • Year and Date
      2015-08-28
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Remarks]

    • URL

      http://www2.tagen.tohoku.ac.jp/lab/nagatsugi/html/

    • Related Report
      2019 Annual Research Report
  • [Remarks]

    • URL

      http://www.tagen.tohoku.ac.jp/labo/nagatsugi/index.html

    • Related Report
      2018 Annual Research Report
  • [Remarks] 永次研

    • URL

      http://www.tagen.tohoku.ac.jp/labo/nagatsugi/index.html

    • Related Report
      2017 Annual Research Report
  • [Remarks]

    • URL

      http://www.tagen.tohoku.ac.jp/labo/nagatsugi/index.html

    • Related Report
      2015 Annual Research Report

URL: 

Published: 2015-07-02   Modified: 2021-02-19  

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