| Budget Amount *help |
¥45,500,000 (Direct Cost: ¥35,000,000、Indirect Cost: ¥10,500,000)
Fiscal Year 2019: ¥8,840,000 (Direct Cost: ¥6,800,000、Indirect Cost: ¥2,040,000)
Fiscal Year 2018: ¥8,840,000 (Direct Cost: ¥6,800,000、Indirect Cost: ¥2,040,000)
Fiscal Year 2017: ¥8,840,000 (Direct Cost: ¥6,800,000、Indirect Cost: ¥2,040,000)
Fiscal Year 2016: ¥8,840,000 (Direct Cost: ¥6,800,000、Indirect Cost: ¥2,040,000)
Fiscal Year 2015: ¥10,140,000 (Direct Cost: ¥7,800,000、Indirect Cost: ¥2,340,000)
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| Outline of Final Research Achievements |
DNA and RNA can also adopt great varieties of stable higher-order structure motifs, such as the G-quadruplex (G4s), mismatch and bulge. Many of these secondary structures were found to be closely related to the control of the gene expression. Therefore, the higher-order structure of nucleic acids is one of the candidates for therapeutic targets. Due to the therapeutic potentials, efforts on the development of small molecule binders to specifically target the higher-order structures of nucleic acids have been intensely carried out. With the aim to augment the stabilization effect, selective alkylation using small molecules targeting the higher-order structures of nucleic acids have also been pursued. In this research we developed the new middle-size molecules with the binding group to target nucleic acids and the alkylating moiety, for alkylation to higher-order structures of nucleic acids.
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