| Budget Amount *help |
¥45,500,000 (Direct Cost: ¥35,000,000、Indirect Cost: ¥10,500,000)
Fiscal Year 2019: ¥8,840,000 (Direct Cost: ¥6,800,000、Indirect Cost: ¥2,040,000)
Fiscal Year 2018: ¥8,840,000 (Direct Cost: ¥6,800,000、Indirect Cost: ¥2,040,000)
Fiscal Year 2017: ¥8,840,000 (Direct Cost: ¥6,800,000、Indirect Cost: ¥2,040,000)
Fiscal Year 2016: ¥8,840,000 (Direct Cost: ¥6,800,000、Indirect Cost: ¥2,040,000)
Fiscal Year 2015: ¥10,140,000 (Direct Cost: ¥7,800,000、Indirect Cost: ¥2,340,000)
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| Outline of Final Research Achievements |
The aim of this work is the development of powerful methods for the synthesis of middle molecular compounds such as solanoeclepin A. Solanoeclepin A has been considered as the key material for exterminating potato cyst nematode, a pest which gives destructive damage to the production of potatoes. We found a practical method for providing a key intermediate of the total synthesis of solanoeclepin A by the use of a flow chemistry. Another important achievement in this work is the total synthesis of brasilicardins. The middle molecular natural compound, which exhibits a potent immunosuppressive activity, consisting of a terpenoid skeleton with an amino acid moiety and sugar units.
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