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環境調和反応の集積化

Planned

Project AreaMiddle molecular strategy: Creation of higher bio-functional molecules by integrated synthesis.
Project/Area Number 15H05846
Research Category

Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

Allocation TypeSingle-year Grants
Review Section Science and Engineering
Research InstitutionKyushu University

Principal Investigator

大嶋 孝志  九州大学, 薬学研究院, 教授 (10313123)

Project Period (FY) 2015-06-29 – 2020-03-31
Project Status Granted (Fiscal Year 2019)
Budget Amount *help
¥45,500,000 (Direct Cost: ¥35,000,000、Indirect Cost: ¥10,500,000)
Fiscal Year 2019: ¥8,840,000 (Direct Cost: ¥6,800,000、Indirect Cost: ¥2,040,000)
Fiscal Year 2018: ¥8,840,000 (Direct Cost: ¥6,800,000、Indirect Cost: ¥2,040,000)
Fiscal Year 2017: ¥8,840,000 (Direct Cost: ¥6,800,000、Indirect Cost: ¥2,040,000)
Fiscal Year 2016: ¥8,840,000 (Direct Cost: ¥6,800,000、Indirect Cost: ¥2,040,000)
Fiscal Year 2015: ¥10,140,000 (Direct Cost: ¥7,800,000、Indirect Cost: ¥2,340,000)
Keywords環境調和型触媒反応 / 空間的集積化 / フロー合成 / 中分子化合物 / アカデミア創薬 / マイクロフロー合成 / 生体共役反応 / 化学選択性
Outline of Annual Research Achievements

アンメット・メディカル・ニーズに応える新薬のリードとして中分子化合物が非常に期待されているが、これまで供給の困難さから医薬品としての中分子の使用は極めて限定的であった。そこで、中分子機能性化合物の大量供給法を開発するために、環境調和型触媒反応の空間的集積化(マイクロフロー合成)と、化学選択性の触媒制御法を基盤とする中分子化合物(ハイブリッド医薬品)の直接合成法の開発を行い、最終的にそれらを融合することで中分子化合物の実用的生産法を開発することを目的として研究を行っている。
平成30年度までに実施した研究で、(1)カルボン酸等価体のα-ヒドロキシル化反応によるα-ヒドロキシエステルの新規合成法の開発、(2)ケチミンに対する末端アルキンおよびβ-ジカルボニル化合物の触媒的不斉求核付加反応を利用したキラルα四置換アミンなどの医薬品ビルディングブロック合成への応用、(3)水酸基選択的なアミノアルコールの触媒的共役付加反応の開発、(4)t-アルコールにも適用可能な高活性二核鉄触媒によるエステル交換反応、(5)弱酸性条件で進行するベンジリック位チオール化反応の開発と生体高分子の機能化、(6)チオノカルボニル化合物を用いた1,3-双極子付加反応による含硫黄ヘテロ環の触媒的合成法の開発、(7)異なるエノラート間の鉄触媒交差クロスカップリング反応の開発、(8)鉄触媒による脱水素型酸化的ベンジル化反応の開発、などに成功した。

Current Status of Research Progress
Current Status of Research Progress

1: Research has progressed more than it was originally planned.

Reason

平成30年度の研究によって以下の成果をあげることができた。
・異種エノラートの触媒的酸化的クロスカップリング反応:エノラートの酸化的クロスカップリング反応は、α位の極性変換を伴わず直接的に1,4-ジカルボニル化合物を合成できる有用な反応であるが、二種類の異なるエノラートを用いた場合、クロスカップリング反応を化学選択的に進行させることは困難であった。我々は、通常は問題となるホモカップリング反応を積極的に利用することで、鉄触媒存在下、高化学選択的に1,4-ジカルボニル化合物を得るエノラートの触媒的酸化的クロスカップリング反応の開発に成功した。得られる化合物は、天然物や医薬品・生理活性物質・有機触媒の構成要素である、α,α-二置換アミノ酸誘導体であり、有機合成化学・創薬化学の観点からも有用である。
・カルボン酸等価体と炭化水素とのクロスカップリング反応:カルボン酸等価体のαアルキル化反応として、来法とは異なるラジカル型のメカニズムによるαアルキル化反応の開発に成功した。本手法はカルボン酸等価体の活性化に強塩基を必要とせず、C-H結合を直接活性化するためアルキル化剤の事前調製も必要とせず、さらに、四級炭素や連続四級炭素の構築も可能である。
その他にも、数種の環境調和型反応の開発と、マイクロ波-フローシステムを用いたフロー反応の開発にも成功している。
以上の研究成果より、本研究課題は「当初の計画以上に進展している」と判断した。

Strategy for Future Research Activity

平成29年度までに行った研究を元に、平成31年度は、それらの研究をさらに発展させるとともに、フロー合成と空間的集積化と天然物や医薬、生体高分子などを直接基質として用いた触媒反応の開発を推し進め、新たな化学選択性の制御方の開発と、中分子合成への応用を検討する。フロー合成に関しては、フロー合成機器の開発や触媒カラムの創製で共同研究を実施しており、高付加価値化合物の実用生産に向けた検討を推し進める予定である。

Report

(4 results)
  • 2018 Annual Research Report
  • 2017 Annual Research Report
  • 2016 Annual Research Report
  • 2015 Annual Research Report

Research Products

(243 results)

All 2019 2018 2017 2016 2015 Other

All Int'l Joint Research Journal Article Presentation Book Remarks Patent(Industrial Property Rights)

  • [Int'l Joint Research] 南洋理工大学(シンガポール)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] 南洋理工大学(シンガポール)

    • Related Report
      2016 Annual Research Report
  • [Journal Article] Mechanistic Insight into Catalytic Aerobic Chemoselective α-Oxidation of Acylpyrazoles2019

    • Author(s)
      Taninokuchi, S.; Yazaki, R.; Ohshima, T.
    • Journal Title

      HETEROCYCLES

      Volume: - Pages: 906-906

    • DOI

      10.3987/com-18-s(f)58

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Ammonium Salt-Accelerated Hydrazinolysis of Unactivated Amides: Mechanistic Investigation and Application to a Microwave Flow Process2019

    • Author(s)
      Noshita, M.; Shimizu, Y.; Morimoto, H.; Akai, S.; Hamashima, Y.; Ohneda, N.; Odajima, H.; Ohshima, T.
    • Journal Title

      Org. Process Res. Dev.

      Volume: -

    • DOI

      10.1021/acs.oprd.8b00424

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Thionoesters as 1,2‐Dipolarophiles for [4+2] Cycloaddition with Cyclobutanones2019

    • Author(s)
      Matsumoto, Y.; Tsuji, T.; Nakatake, D.; Yazaki, R.; Ohshima, T.
    • Journal Title

      Asian Journal of Organic Chemistry

      Volume: -

    • DOI

      10.1002/ajoc.201900156

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Strategy for Catalytic Chemoselective Cross-Enolate Coupling Reaction via a Transient Homocoupling Dimer2018

    • Author(s)
      Tanaka, T.; Tanaka, T.; Tsuji, T.; Yazaki, R.; Ohshima, T.
    • Journal Title

      Organic Letters

      Volume: 20 Pages: 3541-3544

    • DOI

      10.1021/acs.orglett.8b01313

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Chemoselective Catalytic Dehydrogenative Cross-Coupling of 2_Acylimidazoles: Mechanistic Investigations and Synthetic Scope.2018

    • Author(s)
      Taninokuchi Seiya、Yazaki Ryo、Ohshima Takashi
    • Journal Title

      ACS Catal.

      Volume: 19 Pages: 3187-3190

    • DOI

      10.1021/acs.orglett.7b01293

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 3‐Mono‐Substituted BINOL Phosphoric Acids as Effective Organocatalysts in Direct Enantioselective Friedel-Crafts‐Type Alkylation of N‐Unprotected α‐Ketiminoester2018

    • Author(s)
      Yonesaki, R.; Kondo, Y.; Akkad, W.; Sawa, M.; Morisaki, K.; Morimoto, H.; Ohshima, T.
    • Journal Title

      Chemistry A European Jounal

      Volume: 24 Pages: 15211-15214

    • DOI

      10.1002/chem.201804078

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Catalytic Enantioselective Decarboxylative Mannich-Type Reaction of N-Unprotected Isatin-Derived Ketimines2018

    • Author(s)
      Sawa, M.; Miyazaki, S.; Yonesaki, R.; Morimoto, H.; Ohshima, T.
    • Journal Title

      Organic Letters

      Volume: 20 Pages: 5393-5397

    • DOI

      10.1021/acs.orglett.8b02306

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Growth Suppression of Human Colorectal Cancer Cells with Mutated KRAS by 3-Deaza-cytarabine in 3D Floating Culture.2018

    • Author(s)
      Luo, H.; Nishi, K.; Ishikura, S.; Swain, A.; Morishige, N.; Yazaki, R.; Ohshima, T.; Shirasawa, S.; Tsunoda, T.
    • Journal Title

      Anticancer Res

      Volume: 38 Pages: 4247-4256

    • DOI

      10.21873/anticanres.12721

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Development of Direct Enantioselective Alkynylation of α-Ketoester and α-Ketiminoesters Catalyzed by Phenylbis(oxazoline)Rh(III) Complexes2018

    • Author(s)
      森崎 一宏、森本 浩之、真島 和志、大嶋 孝志
    • Journal Title

      J. Syn. Org. Chem., Jpn.

      Volume: 76 Issue: 3 Pages: 226-240

    • DOI

      10.5059/yukigoseikyokaishi.76.226

    • NAID

      130006449132

    • ISSN
      0037-9980, 1883-6526
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Bioconjugation with Thiols by Benzylic Substitution2018

    • Author(s)
      Kenji Watanabe and Takashi Oshima
    • Journal Title

      Chemistry - A European Journal

      Volume: 24 Pages: 3959-3964

    • DOI

      10.1002/chem.201706149

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] An Expeditious Route to trans-Configured Tetrahydrothiophenes Enabled by Fe(OTf)3-Catalyzed [3+2] Cycloaddition of Donor-Acceptor Cyclopropanes with Thionoesters2018

    • Author(s)
      Matsumoto Yohei、Nakatake Daiki、Yazaki Ryo、Ohshima Takashi
    • Journal Title

      Chemistry - A European Journal

      Volume: 24 Pages: 6062-6066

    • DOI

      10.1002/chem.201800957

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Direct Access to N-Unprotected Tetrasubstituted Propargylamines via Direct Catalytic Alkynylation of N-Unprotected Trifluoromethyl Ketimines2017

    • Author(s)
      Morisaki Kazuhiro、Morimoto Hiroyuki、Ohshima Takashi
    • Journal Title

      Chem. Commun.

      Volume: 53 Pages: 6319-6322

    • DOI

      10.1039/c7cc02194a

    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Synthesis of 1-Tetrasubstituted 2,2,2-Trifluoroethylamine Derivatives <i>via</i> Palladium-Catalyzed Allylation of <i>sp</i><sup>3</sup> C–H Bonds2017

    • Author(s)
      Morisaki Kazuhiro、Kondo Yuta、Sawa Masanao、Morimoto Hiroyuki、Ohshima Takashi
    • Journal Title

      CHEMICAL & PHARMACEUTICAL BULLETIN

      Volume: 65 Issue: 11 Pages: 1089-1092

    • DOI

      10.1248/cpb.c17-00580

    • NAID

      130006191510

    • ISSN
      0009-2363, 1347-5223
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Direct Access to N-Unprotected α- and/or β-Tetrasubstituted Amino Acid Esters via Direct Catalytic Mannich-Type Reactions to N-Unprotected Trifluoromethyl Ketimines2017

    • Author(s)
      Sawa Masanao、Morisaki Kazuhiro、Kondo Yuta、Morimoto Hiroyuki、Ohshima Takashi
    • Journal Title

      Chemistry ― A European Journal

      Volume: 23 Pages: 1089-1092

    • DOI

      10.1002/chem.201703516

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Boronic Acid Accelerated Three-Component Reaction for the Synthesis of α-Sulfanyl-Substituted Indole-3-acetic Acids2017

    • Author(s)
      Amrita Das, Kenji Watanabe, Hiroyuki Morimoto and Takashi Ohshima
    • Journal Title

      Organic Letters

      Volume: 19 Pages: 5794-5797

    • DOI

      10.1021/acs.orglett.7b02727

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Metabolomic profiling of brain tissues of mice chronically exposed to heroin2017

    • Author(s)
      R. Li, T. Takeda, T. Ohshima, H. Yamada, Y. Ishii
    • Journal Title

      Drug Metabolism and Pharmacokinetics

      Volume: 32 Pages: 108-111

    • DOI

      10.1016/j.dmpk.2016.10.410

    • NAID

      120006382228

    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Direct Catalytic Alcoholysis of Unactivated 8-Aminoquinoline Amides2017

    • Author(s)
      T. Deguchi, H.-L. Xin, H. Morimoto, T. Ohshima
    • Journal Title

      ACS Catal.

      Volume: 7 Pages: 3157-3161

    • DOI

      10.1021/acscatal.7b00442

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Direct Enantioselective Alkynylation of α-Ketoesters and α-Ketiminoesters Catalyzed by [Bis(oxazoline)phenyl]rhodium(III) Complexes2017

    • Author(s)
      Morimoto, K. Mashima, T. Ohshima
    • Journal Title

      Heterocycles

      Volume: 95 Pages: 637-661

    • DOI

      10.3987/rev-16-sr(s)4

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Catalytic Chemoselective Conjugate Addition of Amino Alcohols to α,β-Unsaturated Ester: Hydroxy Group over Amino Group and Conjugate Addition over Transesterification2017

    • Author(s)
      Z. Li, M. Tamura, R. Yazaki, T. Ohshima
    • Journal Title

      CHEMICAL & PHARMACEUTICAL BULLETIN

      Volume: 65 Issue: 1 Pages: 19-21

    • DOI

      10.1248/cpb.c16-00333

    • NAID

      130005187625

    • ISSN
      0009-2363, 1347-5223
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Diethylenetriamine-Mediated Direct Cleavage of Unactivated Carbamates and Ureas2016

    • Author(s)
      M. Noshita, Y. Shimizu, H. Morimoto, T. Ohshima
    • Journal Title

      Org. Lett.

      Volume: 18 Pages: 6062-6065

    • DOI

      10.1021/acs.orglett.6b03016

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Chemo- and Regioselective Direct Functional Groups Installation through Catalytic Hydroxy Group-Selective Conjugate Addition of Amino Alcohols to α,β-Unsaturated Sulfonyl Compounds2016

    • Author(s)
      Z. Li, R. Yazaki, T. Ohshima
    • Journal Title

      Org. Lett.

      Volume: 18 Pages: 3350-3353

    • DOI

      10.1021/acs.orglett.6b01464

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Chemoselective Transesterification of Acrylate Derivatives for Functionalized Monomer Synthesis through Hard Zinc Alkoxide Generation Strategy2016

    • Author(s)
      D. Nakatake, R. Yazaki, T. Ohshima
    • Journal Title

      Eur. J, Org. Chem.

      Volume: - Pages: 3696-3699

    • DOI

      10.1002/ejoc.201600737

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] &#181;-Oxo-Dinuclear-Iron(III)-Catalyzed O-Selective Acylation of Aliphatic and Aromatic Amino Alcohols and Transesterification of Tertiary Alcohols2016

    • Author(s)
      R. Horikawa, C. Fujimoto, R. Yazaki, T. Ohshima
    • Journal Title

      CHEMISTRY A European Journal

      Volume: 22 Pages: 12278-12281

    • DOI

      10.1002/chem.201602801

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Mechanistic Studies and Expansion of the Substrate Scope of Direct Enantioselective Alkynylation of α-Ketiminoesters Catalyzed by Adaptable (Phebox)Rh(III) Complexes.2016

    • Author(s)
      K. Morisaki, M. Sawa, R. Yonesaki, H. Morimoto, K. Mashima, T. Ohshima
    • Journal Title

      Journal of the American Chemical Society

      Volume: 128 Pages: 6194-6203

    • DOI

      10.1021/jacs.6b01590

    • Related Report
      2016 Annual Research Report 2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Transesterification Reaction Catalyzed by Recyclable Heterogeneous Zinc/Imidazole Catalyst2016

    • Author(s)
      D. Nakatake, R. Yazaki, Y. Matsushima, T. Ohshima
    • Journal Title

      Adv. Synth. Catal.

      Volume: 358 Pages: 2569-2574

    • DOI

      10.1002/adsc.201600229

    • Related Report
      2016 Annual Research Report 2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Studies of the Electronic Effects of Zinc Cluster Catalysts and Their Application to the Transesterification of β-Keto Esters2016

    • Author(s)
      K. Agura, Y. Hayashi, M. Wada, D. Nakatake, K. Mashima, T. Ohshima
    • Journal Title

      Chem. Asian J.

      Volume: 11 Pages: 1548-1554

    • Related Report
      2016 Annual Research Report 2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Development of Tetranuclear Zinc Cluster-Catalyzed Environmentally Friendly Reactions and Mechanistic Studies2016

    • Author(s)
      T. Ohshima
    • Journal Title

      CHEMICAL & PHARMACEUTICAL BULLETIN

      Volume: 64 Issue: 6 Pages: 523-539

    • DOI

      10.1248/cpb.c16-00028

    • NAID

      130005154408

    • ISSN
      0009-2363, 1347-5223
    • Related Report
      2016 Annual Research Report 2015 Annual Research Report
    • Acknowledgement Compliant
  • [Journal Article] Isomeric iodinated analogs of nimesulide: Synthesis, physicochemical characterization, cyclooxygenase-2 inhibitory activity, and transport across Caco-2 cells2016

    • Author(s)
      Y. Yamamoto, J. Arai, T. Hisa, Y. Saito, T. Mukai, T. Ohshima, M. Maeda, F. Yamamoto
    • Journal Title

      Bioorganic & Medicinal Chemistry

      Volume: 24 Pages: 3727-3733

    • DOI

      10.1016/j.bmc.2016.06.015

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Synthesis of radioiodinated probes to evaluate the biodistribution of a potent TRPC3 inhibitor.2016

    • Author(s)
      M. Hagimori, T. Murakami, K. Shimizu, M. Nishida, T. Ohshima, T. Mukai
    • Journal Title

      Medicinal Chemical Communications

      Volume: 7 Pages: 1003-1006

    • DOI

      10.1039/c6md00023a

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Direct Catalytic Chemoselective α-Amination of Acylpyrazoles: A Concise Route to Unnaturαal α-Amino Acid Derivatives2016

    • Author(s)
      K. Tokumasu, R. Yazaki, T. Ohshima
    • Journal Title

      J. Am. Chem. Soc.

      Volume: 138 Pages: 2664-2669

    • DOI

      10.1021/jacs.5b11773

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] A Highly Stable but Highly Reactive Zinc Catalyst for Transesterification Supported by Bis(imidazole) Ligand2016

    • Author(s)
      D. Nakatake, Y. Yokote, Y. Matsushima, R. Yazakia, T. Ohshima
    • Journal Title

      Green Chem.

      Volume: 18 Pages: 1524-1530

    • DOI

      10.1039/c5gc02056e

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Isomeric methoxy analogs of nimesulide for development of brain cyclooxygense-2 (COX-2)-targeted imaging agents: Synthesis, in vitro COX-2-inhibitory potency, and cellular transport properties2016

    • Author(s)
      Yamamoto Y., Hisa T., Arai J., Saito Y., Yamamoto F., Mukai T., Ohshima T., Maeda M. and Ohkubo Y
    • Journal Title

      Bioorganic & Medicinal Chemistry

      Volume: 23 Pages: 1524-1530

    • DOI

      10.1016/j.bmc.2015.10.007

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] A novel anti-microtubule agent with carbazole and benzohydrazide structures suppresses tumor cell growth in vivo.2015

    • Author(s)
      M. Ohira, Y. Iwasaki, C. Tanaka, M. Kuroki, N. Matsuo, T. Kitamura, M. Yukuhiro, H. Morimoto, N. Pang, B. Liu, T. Kiyono, M. Amemiya, K. Tanaka, K. Yoshida, N. Sugimoto, T. Ohshima, M. Fujita
    • Journal Title

      Biochim Biophys Acta

      Volume: 1850 Pages: 1676-1684

    • DOI

      10.1016/j.bbagen.2015.04.013

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Presentation] エステル交換反応に利用する高機能亜鉛触媒の開発2019

    • Author(s)
      中武大貴、横手友紀、松嶋義正、矢崎亮、大嶋孝志
    • Organizer
      第21回システム創薬リサーチコア研究会/第20回薬学研究院若手セミナー
    • Related Report
      2018 Annual Research Report
  • [Presentation] 環境調和反応の集積化を目指して2019

    • Author(s)
      大嶋孝志
    • Organizer
      第6回 新学術領域「反応集積化が導く中分子戦略: 高次生物機能分子の創製」若手シンポジウム
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Development of Greener Synthetic Methods of Amines Having Tetrasubstituted Carbon Stereocenters2019

    • Author(s)
      森本浩之
    • Organizer
      日本化学会第99春季年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Uncatalyzed direct C-C Bond Cleavage of 2-Acylimidazoles2019

    • Author(s)
      XIN, Hailong; AKKAD, Walaa; MORIMOTO, Hiroyuki; OHSHIMA, Takashi
    • Organizer
      日本化学会第99春季年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Uncatalyzed direct C-C Bond Cleavage of 2-Acylimidazoles2019

    • Author(s)
      XIN, Hailong; AKKAD, Walaa; MORIMOTO, Hiroyuki; OHSHIMA, Takashi
    • Organizer
      日本薬学会第139年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 窒素上無保護ケチミンの新規触媒的直接合成法の開発2019

    • Author(s)
      近藤優太、森崎一宏、平澤禎将、門田哲弥、森本浩之、大嶋孝志
    • Organizer
      日本薬学会第139年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] チオノエステルとシクロブタノンの[4+2]環化付加反応によるテトラヒドロチオピランの合成2019

    • Author(s)
      松本洋平、中武大貴、辻汰朗、矢崎亮、大嶋孝志
    • Organizer
      日本薬学会第139年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 窒素上無保護のケチミンに対する触媒的脱炭酸的不斉マンニッヒ型反応の進展2019

    • Author(s)
      宮崎翔太郎、澤真尚、森本浩之、大嶋孝志
    • Organizer
      日本薬学会第139年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 低級エステルを原料とした化学反応開発2018

    • Author(s)
      中武大貴、松本洋平、横手友紀、松嶋義正、矢崎亮、大嶋孝志
    • Organizer
      第16回次世代を担う有機化学シンポジウム
    • Related Report
      2018 Annual Research Report
  • [Presentation] チオノエステルを用いた環化付加反応~エステルの新たな可能性を拓く~2018

    • Author(s)
      中武大貴、松本洋平、矢崎亮、大嶋孝志
    • Organizer
      福岡万有福岡シンポジウム第12回三地区若手交歓会
    • Related Report
      2018 Annual Research Report
  • [Presentation] カルボン酸等価体の触媒的酸化的α-ベンジル化反応2018

    • Author(s)
      田中津久志、橋口佳代子、田中尊書、矢崎亮、大嶋孝志
    • Organizer
      第28回万有福岡シンポジウム
    • Related Report
      2018 Annual Research Report
  • [Presentation] Catalytic α-Amination of Acylpyrazoles and Catalytic Addition of Various Nucleophile to N-Unprotected α-Ketiminnoesters for the Synthesis of Unnatural α-Amino Acid Derivatives2018

    • Author(s)
      大嶋孝志
    • Organizer
      名古屋大学Organic Seminar
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 無保護ケチミンへの直接的触媒的求核付加反応の開発2018

    • Author(s)
      大嶋孝志
    • Organizer
      新学術領域研究 「反応集積化が導く中分子戦略:高次生物機能分子の創製」第6回成果報告会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 新規BINOLリン酸触媒による窒素上無保護a-ケチミノエステルへの直接的不斉Friedel-Crafts反応の開発と反応機構解析2018

    • Author(s)
      米嵜 凌平、近藤 優太、Akkad Walaa、澤 真尚、森崎 一宏、森本 浩之、大嶋 孝志
    • Organizer
      第113回有機合成シンポジウム2018年【春】
    • Related Report
      2018 Annual Research Report
  • [Presentation] 窒素上無保護ケチミンの新規触媒的直接合成法の開発2018

    • Author(s)
      近藤 優太, 森崎 一宏, 平澤 禎将, 森本 浩之, 大嶋 孝志
    • Organizer
      第7回 JACI/GSCシンポジウム
    • Related Report
      2018 Annual Research Report
  • [Presentation] β-C-H Amination of α-Amino Acid Derivatives2018

    • Author(s)
      Yuri Tabuchi、Seiya Taninokuchi、Ryo Yazaki、Takashi Ohshima
    • Organizer
      創薬懇話会2018
    • Related Report
      2018 Annual Research Report
  • [Presentation] Mechanistic studies of BINOL-derived phosphoric acid as effective catalysts in direct enantioselective Friedel-Crafts-type alkylation of N-unprotectedα-ketiminoester2018

    • Author(s)
      Walaa Akkad, Masanao Sawa, Kazuhiro Morisaki, Hiroyuki Morimoto, Takashi Ohshima
    • Organizer
      第55回化学関連支部合同九州大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] チオノエステルとDAシクロプロパンの触媒的[3+2]環化付加反応によるテトラヒドロチオフェンの合成2018

    • Author(s)
      松本洋平、中武大貴、矢崎亮、大嶋孝志
    • Organizer
      第55回化学関連支部合同九州大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 窒素上無保護のケチミンに対する触媒的脱炭酸的不斉マンニッヒ型反応の開発2018

    • Author(s)
      宮崎翔太郎、米嵜凌平、森本浩之、大嶋孝志
    • Organizer
      第55回化学関連支部合同九州大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 保護基・活性化基に頼らない直接触媒反応2018

    • Author(s)
      大嶋 孝志
    • Organizer
      万有札幌シンポジウム
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Development of Mild and Selective Oxidative Heck Reaction to Derivatize Complex Molecules and Reactivity Study of Heteroarenes2018

    • Author(s)
      Takashi Ohshima, Das Amrita, Takumi Kimijima, Kenji Watanabe_
    • Organizer
      28th International Conference on Organometallic Chemistry
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 窒素上無保護ケチミンの新規触媒的直接合成法開発2018

    • Author(s)
      近藤 優太, 森崎 一宏, 平澤 禎将, 森本 浩之, 大嶋 孝志
    • Organizer
      日本プロセス化学会2017サマーシンポジウム
    • Related Report
      2018 Annual Research Report
  • [Presentation] Development and Mechanistic Studies of (Phebox)Rh(III)-Catalyzed Direct Enantioselective Alkynylation of α-Ketiminoesters2018

    • Author(s)
      Hiroyuki Morimoto, Kazuhiro Morisaki, Masanao Sawa, Ryohei Yonesaki, Kazushi Mashima, Takashi Ohshima
    • Organizer
      The 43rd International Conference on Coordination Chemistry (ICCC2018)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Development of Direct Catalysis without Using Protecting or Activating Group2018

    • Author(s)
      Takashi Ohshima
    • Organizer
      Asian Core Program Lectureship (Taiwan)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Catalytic Addition of Various Nucleophile to N-Unprotected Ketimines for the Synthesis of Unnatural a-Amino Acid Derivatives2018

    • Author(s)
      Takashi Ohshima
    • Organizer
      The 1st Scripps Korea Society Symposium
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 無保護ケチミンを活用した四置換炭素含有無保護アミノ酸誘導体の触媒的直接合成法の開発2018

    • Author(s)
      森本 浩之
    • Organizer
      第5回新学術領域研究「反応集積化が導く中分子戦略:高次生物機能分子の創製」若手シンポジウム
    • Related Report
      2018 Annual Research Report
  • [Presentation] Efficient use of lower ester compounds: Catalytic transesterification and cycloaddition2018

    • Author(s)
      Daiki Nakatake, Yohei Matsumoto, Ryo Yazaki, Takashi Ohshima
    • Organizer
      256nd American Chemical Society National Meeting & Exposition
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Catalytic Oxidative α-Benzylation of Carboxylic Acid Equivalents2018

    • Author(s)
      Tsukushi Tanaka, Kayoko Hashiguchi, Takafumi Tanaka, Ryo Yazaki, Takashi Ohshima
    • Organizer
      4th International Symposium on C-H Activation (ISCHA-4)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] チオノエステルとDAシクロプロパンの触媒的[3+2]環化付加反応によるテトラヒドロチオフェンの合成2018

    • Author(s)
      松本洋平、中武大貴、矢崎亮、大嶋孝志
    • Organizer
      第30回若手研究者のためのセミナー
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Mechanistic studies of BINOL-derived phosphoric acid as effective catalysts in direct enantioselective Friedel-Crafts-type alkylation of N-unprotected alpha-ketiminoester2018

    • Author(s)
      Walaa Akkad, Ryohei Yonesaki, Yuta Kondo, Masanao Sawa, Kazuhiro Morisaki, Hiroyuki Morimoto and Takashi Ohshima
    • Organizer
      第30回若手研究者のためのセミナー
    • Related Report
      2018 Annual Research Report
  • [Presentation] 地球に優しい薬づくり グリーンファルマのためのグリーンケミストリー2018

    • Author(s)
      大嶋孝志
    • Organizer
      九州大学薬学部 公開講座
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] チオノエステルと DA シクロプロパンの触媒的[3+2]環化付加反応によるテトラヒドロチオフェンの合成2018

    • Author(s)
      松本洋平、中武大貴、矢崎亮、大嶋孝志
    • Organizer
      第48回複素環化学討論会
    • Related Report
      2018 Annual Research Report
  • [Presentation] イサチン由来の窒素上無保護のケチミンに対する触媒的脱炭酸的不斉マンニッヒ型反応の開発2018

    • Author(s)
      澤真尚、宮崎翔太郎、米嵜凌平、森本浩之、大嶋孝志
    • Organizer
      第48回複素環化学討論会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Mechanistic studies of BINOL-derived phosphoric acid as effective catalysts in direct enantioselective Friedel-Crafts-type alkylation of N-unprotected alpha-ketiminoester2018

    • Author(s)
      Walaa Akkad, Ryohei Yonesaki, Yuta Kondo, Masanao Sawa, Kazuhiro Morisaki, Hiroyuki Morimoto and Takashi Ohshima
    • Organizer
      第20回システム創薬リサーチコア研究会/第19回薬学研究院若手セミナー
    • Related Report
      2018 Annual Research Report
  • [Presentation] チオノエステルとDAシクロプロパンの触媒的[3+2]環化付加反応によるテトラヒドロチオフェンの合成2018

    • Author(s)
      松本洋平、中武大貴、矢崎亮、大嶋孝志
    • Organizer
      第35回有機合成化学セミナー
    • Related Report
      2018 Annual Research Report
  • [Presentation] Uncatalyzed C_C bond cleavage of 2-acylimidazoles2018

    • Author(s)
      Hai-Long Xin, Walaa Akkad, Hiroyuki Morimoto, Takashi Ohshima
    • Organizer
      The 35rd organic synthetic chemistry seminar
    • Related Report
      2018 Annual Research Report
  • [Presentation] 窒素上無保護ケチミンへの触媒的求核付加を活用した四置換炭素構築反応の開発2018

    • Author(s)
      森本浩之、森崎一宏、澤真尚、宮崎翔太郎、米嵜凌平、大嶋孝志
    • Organizer
      第65回有機金属化学討論会
    • Related Report
      2018 Annual Research Report
  • [Presentation] アシルピラゾールをカルボン酸等価体プラットフォームとする化学選択的触媒反応2018

    • Author(s)
      矢崎亮、谷之口誠也、徳益圭祐、大嶋孝志
    • Organizer
      第60回天然有機化合物討論会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 化学選択性の精密制御のための触媒反応設計2018

    • Author(s)
      矢崎亮
    • Organizer
      第2回 産総研化学研究シンポジウム
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Catalytic Chemoselective Cross-Enolate Coupling Reaction via a Transient Homo-Coupling Dimer2018

    • Author(s)
      Takashi Ohshima, Takafumi Tanaka, Tsukushi Tanaka, Taro Tsuji, Ryo Yazaki
    • Organizer
      The 13th International Conference on Cutting-Edge Organic Chemistry in Asia (ICCEOCA-13)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 2-アシルイミダゾールの化学選択的な触媒的脱水素型クロスカップリング反応2018

    • Author(s)
      田中津久志,橋口佳代子,田中尊書,矢崎亮,大嶋孝志
    • Organizer
      第44回反応と合成の進歩シンポジウム
    • Related Report
      2018 Annual Research Report
  • [Presentation] 窒素上無保護のケチミンに対する直接的脱炭酸的不斉マンニッヒ型反応の開発2018

    • Author(s)
      宮崎翔太郎、米嵜凌平、森本浩之、大嶋孝志
    • Organizer
      第44回反応と合成の進歩シンポジウム
    • Related Report
      2018 Annual Research Report
  • [Presentation] カルボン酸等価体の触媒的酸化的α-ベンジル化反応2018

    • Author(s)
      田中津久志、橋口佳代子、田中尊書、矢崎亮、大嶋孝志
    • Organizer
      第44回反応と合成の進歩シンポジウム
    • Related Report
      2018 Annual Research Report
  • [Presentation] Catalytic Chemoselective Cross-Enolate Coupling Reaction via a Transient Homo-Coupling Dimer2018

    • Author(s)
      Takashi Ohshima
    • Organizer
      Tateshina Conference on Organic Chemistry
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Uncatalyzed C_C bond cleavage of 2-acylimidazoles2018

    • Author(s)
      Hai-Long Xin, Walaa Akkad, Hiroyuki Morimoto, Takashi Ohshima
    • Organizer
      The 14th International Kyoto Conference on New Aspects of Organic Chemistry (IKCOC-14)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Chemoselective Catalytic Dehydrogenative Cross Coupling of 2-Acylimidazoles2018

    • Author(s)
      Ryo Yazaki, Tsukushi Tanaka, Kayoko Hashiguchi, Takafumi Tanaka, Takashi Ohshima
    • Organizer
      The 14th International Kyoto Conference on New Aspects of Organic Chemistry (IKCOC-14)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 窒素上無保護のケチミンに対する触媒的脱炭酸的不斉Mannich型反応の開発2018

    • Author(s)
      宮崎翔太郎、澤真尚、米嵜凌平、森本浩之、大嶋孝志
    • Organizer
      第35回日本薬学会九州支部大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 触媒的酸化的クロスカップリング反応を用いたα,β-連続四置換炭素含有α-アミノ酸の合成2018

    • Author(s)
      橋口佳代子、田中津久志、矢崎亮、大嶋孝志
    • Organizer
      第35回日本薬学会九州支部大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] α-アミノ酸誘導体のβ位アミノ化反応の開発2018

    • Author(s)
      田渕 友梨、谷之口 誠也、矢崎亮、大嶋孝志
    • Organizer
      第35回日本薬学会九州支部大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 窒素上無保護ケチミンの新規触媒的直接合成法の開発2018

    • Author(s)
      近藤優太、森崎一宏、平澤禎将、門田哲弥、森本浩之、大嶋孝志
    • Organizer
      第35回日本薬学会九州支部大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 地球に優しい薬づくり グリーンファルマのためのグリーンケミストリー2018

    • Author(s)
      大嶋孝志
    • Organizer
      2018年度 よか薬会講演会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 保護基・活性化基に頼らない直接触媒反応2018

    • Author(s)
      大嶋孝志
    • Organizer
      平成30年度(後期)有機合成化学講習会「有機合成の底力 ―新手法・新材料・創薬― 」
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Catalytic Chemoselective Cross-Enolate Coupling Reaction via a Transient Homo-Coupling Dimer2018

    • Author(s)
      Takashi Ohshima
    • Organizer
      The 13th International Symposium on Organic Reactions (ISOR-13)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Construction of Tetrasubstituted Carbon Stereocenters via Catalytic Nucleophilic Additions to N-Unprotected Ketimines2018

    • Author(s)
      Takashi Ohshima
    • Organizer
      6th Japan_UK Symposium on Asymmetric Catalysis
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Catalytic Chemoselective Cross-Enolate Coupling Reaction2018

    • Author(s)
      Takashi Ohshima, Takafumi Tanaka, Tsukushi Tanaka, Taro Tsuji and Ryo Yazaki
    • Organizer
      The 4th International Symposium on Middle Molecular Strategy (ISMMS-4)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 窒素上無保護α-ケチミノエステルに対する有機触媒を用いた直接的不斉求核付加反応の開発2018

    • Author(s)
      森本浩之・米嵜凌平・澤真尚・近藤優太、Walaa Akkad・森崎一宏・大嶋孝志
    • Organizer
      第11回有機触媒シンポジウム
    • Related Report
      2018 Annual Research Report
  • [Presentation] トリフルオロメチル基の特性を活かした触媒反応開発:リガンドとして、基質として2018

    • Author(s)
      大嶋孝志
    • Organizer
      2018 ハロゲン利用ミニシンポジウム(第11回臭素化学懇話会年会)
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 化学選択性の精密制御のための触媒反応設計2018

    • Author(s)
      矢崎亮
    • Organizer
      第14回IoLコロキウム―特別講演会―
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Catalytic a-Amination of Acylpyrazoles and Catalytic Addition of Various Nucleophile to N-Unprotected a-Ketimins for the Synthesis of Unnatural a-Amino Acid Derivatives2018

    • Author(s)
      Takashi Ohshima
    • Organizer
      Asian Core Program Lectureship (Singapore)
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Direct Catalytic Asymmetric Addition of Various Nucleophiles to N-Unprotected Ketimines2018

    • Author(s)
      Takashi Ohshima
    • Organizer
      IRCCS-JST CREST Joint Symposium (IMCE)
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Direct Catalytic Chemoselective Oxidative Cross-Enolate Coupling Reaction Via a Transient Homo-Coupling Dimer2018

    • Author(s)
      Takafumi Tanaka, Tsukushi Tanaka, Ryo Yazaki, Takashi Ohshima
    • Organizer
      IRCCS-JST CREST Joint Symposium (IMCE)
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Catalytic Aerobic Chemoselective α-Oxidation of Acylpyrazoles2018

    • Author(s)
      Seiya Taninokuchi, Ryo Yazaki, Takashi Ohshima
    • Organizer
      IRCCS-JST CREST Joint Symposium (IMCE)
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Ni(II)-Catalyzed Direct Alcoholysis of Unactivated 8-Aminoquinoline Amides2018

    • Author(s)
      Toru Deguchi, Hai-Long Xin, Hiroyuki Morimoto, Takashi Ohshima
    • Organizer
      IRCCS-JST CREST Joint Symposium (IMCE)
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] カルボン酸等価体の触媒的酸化的α-ベンジル化反応2018

    • Author(s)
      田中津久志、橋口佳代子、田中尊書、矢崎亮、大嶋孝志
    • Organizer
      IRCCS-JST CREST Joint Symposium (IMCE)
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Direct Catalytic Asymmetric Addition of Various Nucleophiles to N-Unprotected Ketimines2018

    • Author(s)
      Takashi Ohshima
    • Organizer
      International Congress on Pure & Applied Chemistry (ICPAC) 2018
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Chemoselective Oxidative Cross-Enolate Coupling2018

    • Author(s)
      Yazaki Ryo, Tanaka Takafumi, Tanaka Tsukushi, Ohshima Takashi
    • Organizer
      日本化学会第98春季年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Direct Catalytic Alcoholysis of Unactivated 8 Aminoquinoline Amides2018

    • Author(s)
      DEGUCHI, Toru・XIN, Hailong・MORIMOTO, Hiroyuki・OHSHIMA
    • Organizer
      日本化学会第98春季年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Pd触媒によるアリル化を活用した1位四置換2,2,2-トリフルオロエチルアミン類の合成法の開発2018

    • Author(s)
      森本浩之、森崎一宏、近藤優太、澤真尚、大嶋孝志
    • Organizer
      日本薬学会第138年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 窒素上無保護のケチミンに対する触媒的脱炭酸的不斉マンニッヒ型反応の開発2018

    • Author(s)
      澤真尚、宮崎翔太郎、森本浩之、大嶋孝志
    • Organizer
      日本薬学会第138年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Lewis酸触媒によるチオノエステルとDAシクロプロパンの[3+2]環化付加反応2018

    • Author(s)
      中武大貴、松本洋平、矢崎亮、大嶋孝志
    • Organizer
      日本薬学会第138年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 8-アミノキノリンアミドの直接的触媒的加アルコール分解反応の開発2018

    • Author(s)
      出口亨、辛海龍、森本浩之、大嶋孝志
    • Organizer
      日本薬学会第138年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] ヒドラジドの触媒的ワンポットエステル化反応の開発2018

    • Author(s)
      久保 友梨香、森本 浩之、大嶋 孝志
    • Organizer
      日本薬学会第138年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] カルボン酸等価体の触媒的酸化的α-ベンジル化反応2018

    • Author(s)
      田中津久志、橋口佳代子、田中尊書、矢崎亮、大嶋孝志
    • Organizer
      日本薬学会第138年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 化学選択性の精密制御のための触媒反応の開発2017

    • Author(s)
      矢崎亮
    • Organizer
      日本薬学会第137年会
    • Place of Presentation
      仙台国際センター、東北大学川内キャンパス(宮城)
    • Year and Date
      2017-03-24
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Development of an oxidative Mizoroki-Heck reaction for late-stage C-H functionalization of complex molecules and application to pharmaceutical studies2017

    • Author(s)
      Kenji Watanabe, Amrita Das, Takumi Kimijima, Tomohiro Yamashita, Kazuhide Inoue, Makoto Tsuda, Takashi Ohshima
    • Organizer
      日本薬学会第137年会
    • Place of Presentation
      仙台国際センター、東北大学川内キャンパス(宮城)
    • Year and Date
      2017-03-24
    • Related Report
      2016 Annual Research Report
  • [Presentation] 新規BINOLリン酸触媒を用いた窒素上無保護のα-ケチミノエステルに対する直接的触媒的不斉Friedel-Cra1sアルキル化反応の開発2017

    • Author(s)
      米嵜 凌平、近藤 優太、澤 真尚、森崎 一宏、森本 浩之、大嶋 孝志
    • Organizer
      日本薬学会第137年会
    • Place of Presentation
      仙台国際センター、東北大学川内キャンパス(宮城)
    • Year and Date
      2017-03-24
    • Related Report
      2016 Annual Research Report
  • [Presentation] ジエチレントリアミンを用いたカーバメートおよびウレアの切断反応の開発2017

    • Author(s)
      野下めぐみ、清水悠平、森本浩之、大嶋孝志
    • Organizer
      日本薬学会第137年会
    • Place of Presentation
      仙台国際センター、東北大学川内キャンパス(宮城)
    • Year and Date
      2017-03-24
    • Related Report
      2016 Annual Research Report
  • [Presentation] 窒素上無保護のα-ketiminoesterに対する直接的触媒的不斉Mannich反応の開発2017

    • Author(s)
      澤真尚、森崎一宏、近藤優太、森本浩之、大嶋孝志
    • Organizer
      日本薬学会第137年会
    • Place of Presentation
      仙台国際センター、東北大学川内キャンパス(宮城)
    • Year and Date
      2017-03-24
    • Related Report
      2016 Annual Research Report
  • [Presentation] ホモカップリング体形成を活用したエノラートの触媒的酸化的クロスカップリング反応の開発2017

    • Author(s)
      田中尊書、田中津久志、矢崎亮、大嶋孝志
    • Organizer
      日本薬学会第137年会
    • Place of Presentation
      仙台国際センター、東北大学川内キャンパス(宮城)
    • Year and Date
      2017-03-24
    • Related Report
      2016 Annual Research Report
  • [Presentation] N無保護トリフルオロメチルケチミンに対する直接的触媒的アルキニル化反応2017

    • Author(s)
      森崎一宏、近藤優太、森本浩之、大嶋孝志
    • Organizer
      日本薬学会第137年会
    • Place of Presentation
      仙台国際センター、東北大学川内キャンパス(宮城)
    • Year and Date
      2017-03-24
    • Related Report
      2016 Annual Research Report
  • [Presentation] アシルピラゾールの酸素雰囲気下における触媒的化学選択的α位酸化反応2017

    • Author(s)
      谷之口 誠也、河上 龍馬、矢崎 亮、大嶋 孝志
    • Organizer
      日本薬学会第137年会
    • Place of Presentation
      仙台国際センター、東北大学川内キャンパス(宮城)
    • Year and Date
      2017-03-24
    • Related Report
      2016 Annual Research Report
  • [Presentation] Chemoselective Catalytic Conjugate Addition of Hydroxy Group over Amino Group2017

    • Author(s)
      Zhao Li, Shuhei Uesugi, Masamichi Tamura, Ryo Yazaki, Takashi Ohshima
    • Organizer
      日本化学会第97春季年会
    • Place of Presentation
      慶應義塾大学 日吉キャンパス(横浜)
    • Year and Date
      2017-03-16
    • Related Report
      2016 Annual Research Report
  • [Presentation] Construction of Tetrasubstituted Carbon Stereocenters via Direct Catalytic Nucleophilic Addition to Ketimines2017

    • Author(s)
      Hiroyuki Morimoto, Kazuhiro Morisaki, Masanao Sawa, Ryohei Yonesaki, Yuta Kondo, Kazushi Mashima, Takashi Ohshima
    • Organizer
      日本化学会第97春季年会
    • Place of Presentation
      慶應義塾大学 日吉キャンパス(横浜)
    • Year and Date
      2017-03-16
    • Related Report
      2016 Annual Research Report
  • [Presentation] Direct Catalytic Asymmetric Addition of Various Nucleophiles to N-Unprotected Ketimines2017

    • Author(s)
      Ohshima Takashi
    • Organizer
      International Symposium on Green Chemistry 2017 (ISGC-2017)
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Development of Mild and Selective Oxidative Heck Reaction to Derivatize Complex Molecules and Reactivity Study of Heteroarenes2017

    • Author(s)
      Das Amrita, Takumi Kimijima, Kenji Watanabe, Makoto Tsuda, Takashi Ohshima
    • Organizer
      International Symposium on Green Chemistry 2017 (ISGC-2017)
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 窒素上無保護のケチミンに対する直接的触媒的不斉Mannich反応の開発2017

    • Author(s)
      澤真尚、森崎一宏、近藤優太、森本浩之、大嶋孝志
    • Organizer
      第15回次世代を担う有機化学シンポジウム
    • Related Report
      2017 Annual Research Report
  • [Presentation] 窒素上無保護のケチミンに対する直接的触媒的不斉Mannich反応の開発2017

    • Author(s)
      澤真尚、森崎一宏、近藤優太、森本浩之、大嶋孝志
    • Organizer
      第27回万有福岡シンポジウム
    • Related Report
      2017 Annual Research Report
  • [Presentation] 温和な条件下でのアミド結合切断および形成反応の開発2017

    • Author(s)
      森本浩之、清水悠平、野下めぐみ、藤原理沙、大嶋孝志
    • Organizer
      第111回有機合成シンポジウム2017年【春】
    • Related Report
      2017 Annual Research Report
  • [Presentation] Catalytic Hydroxy Group-selective Conjugate Addition of Unprotected Amino Alcohols2017

    • Author(s)
      Zhao Li, Ryo Yazaki, Takashi Ohshima
    • Organizer
      第111回有機合成シンポジウム2017年【春】
    • Related Report
      2017 Annual Research Report
  • [Presentation] 新規BINOLリン酸触媒を用いた窒素上無保護のα-ケチミノエステルに対する直接的触媒的不斉Friedel-Craftsアルキル化反応の開発2017

    • Author(s)
      米嵜 凌平、近藤 優太、澤 真尚、森崎 一宏、森本 浩之、大嶋 孝志
    • Organizer
      第111回有機合成シンポジウム2017年【春】
    • Related Report
      2017 Annual Research Report
  • [Presentation] Direct Catalytic Asymmetric Addition to N-Unprotected Ketimines2017

    • Author(s)
      Takashi Ohshima
    • Organizer
      International Symposium on Pure & Applied Chemistry (ISPAC) 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Direct Catalytic Asymmetric Addition of Various Nucleophiles to N-Unprotected Ketimines2017

    • Author(s)
      Takashi Ohshima
    • Organizer
      The 19th IUPAC International Symposium on Organometallic Chemistry Directed Towards Organic Synthesis (OMCOS19)
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Chemo- and Regioselective Catalytic Conjugate Addition of Hydroxy Group over Amino Group2017

    • Author(s)
      Zhao Li, Ryo Yazaki, Takashi Ohshima
    • Organizer
      The 19th IUPAC International Symposium on Organometallic Chemistry Directed Towards Organic Synthesis (OMCOS19)
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 窒素上無保護のケチミンに対する直接的触媒的不斉Mannich反応の開発2017

    • Author(s)
      澤真尚、森崎一宏、近藤優太、森本浩之、大嶋孝志
    • Organizer
      第29回万有札幌シンポジウム
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Direct Catalytic Alcoholysis of Unactivated 8-Aminoquinoline Amides2017

    • Author(s)
      Hai-Long Xin, Toru Deguchi, Hiroyuki Morimoto, and Takashi Ohshima
    • Organizer
      第54回化学関連支部合同九州大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 新規BINOL リン酸触媒を用いた窒素上無保護のα-ケチミノエステルに対する直接的触媒的不斉Friedel-Crafts アルキル化反応の開発2017

    • Author(s)
      米嵜凌平、近藤優太、澤真尚、森崎一宏、森本浩之、大嶋孝志
    • Organizer
      第54回化学関連支部合同九州大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] エステル等価体の触媒的酸化的α-ベンジル化反応の開発2017

    • Author(s)
      田中津久志、田中尊書、矢崎亮、大嶋孝志
    • Organizer
      第54回化学関連支部合同九州大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Novel C1-Symmetric BINOL Phosphoric Acid-Catalyzed Direct Catalytic Enantioselective Friedel-Crafts Alkylation to N-Unprotected α-Ketiminoester2017

    • Author(s)
      Ryohei Yonesaki, Yuta Kondo, Masanao Sawa, Kazuhiro Morisaki, Hiroyuki Morimoto, Takashi Ohshima
    • Organizer
      29th The International Symposium on Chirality
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Direct Catalytic Asymmetric Mannich-type Reaction of N-Unprotected Ketimines2017

    • Author(s)
      Masanao Sawa, Kazuhiro Morisaki, Yuta Kondo, Hiroyuki Morimoto, Takashi Ohshima
    • Organizer
      8th International Conference on Green and Sustainable Chemistry
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Environmentally Friendly Ester Synthesis Reactions Catalyzed by Developed Zinc Catalysts2017

    • Author(s)
      Daiki Nakatake,Yuki Yokote,Yoshimasa Matsushima, Ryo Yazaki, Takashi Ohshima
    • Organizer
      8th International Conference on Green and Sustainable Chemistry
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] リサイクル可能な亜鉛担持固相触媒によるエステル交換反応2017

    • Author(s)
      中武大貴, 矢崎亮, 松嶋義正, 大嶋孝志
    • Organizer
      日本プロセス化学会2017サマーシンポジウム
    • Related Report
      2017 Annual Research Report
  • [Presentation] 8-アミノキノリンアミドの直接的触媒的加アルコール分解反応の開発2017

    • Author(s)
      出口亨、辛海龍、森本浩之、大嶋孝志
    • Organizer
      第50回有機金属若手の会夏の学校
    • Related Report
      2017 Annual Research Report
  • [Presentation] エステル等価体の触媒的酸化的α-ベンジル化反応の開発2017

    • Author(s)
      田中 津久志、橋口 佳代子、田中 尊書、矢崎 亮、大嶋 孝志
    • Organizer
      第50回有機金属若手の会夏の学校
    • Related Report
      2017 Annual Research Report
  • [Presentation] エステル等価体の触媒的酸化的α-アルキル化反応の開発2017

    • Author(s)
      田中津久志、橋口佳代子、田中尊書、矢崎亮、大嶋孝志
    • Organizer
      第29回若手研究者のためのセミナー
    • Related Report
      2017 Annual Research Report
  • [Presentation] 新規BINOL リン酸触媒を用いた窒素上無保護のα-ケチミノエステルに対する直接的触媒的不斉Friedel-Crafts アルキル化反応の開発2017

    • Author(s)
      近藤優太、米嵜凌平、澤真尚、森崎一宏、森本浩之、大嶋孝志
    • Organizer
      第29回若手研究者のためのセミナー
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Hydrazine and Diethylenetriamine Mediated Direct Cleavage of Unactivated Amides, Carbamates, and Ureas2017

    • Author(s)
      Megumi Noshita, Yuhei Shimizu, Hiroyuki Morimoto, Takashi Ohshima
    • Organizer
      254nd American Chemical Society National Meeting & Exposition
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] New Zinc and Iron Catalysts for Transesterification2017

    • Author(s)
      Takashi Ohshima
    • Organizer
      World Chemistry Conference & Exhibition
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Catalytic chemoselective oxidative cross-enolate coupling Reaction2017

    • Author(s)
      Ryo Yazaki, Takafumi Tanaka, Tsukushi Tanaka and Takashi Ohshima
    • Organizer
      第64回有機金属化学討論会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 8-アミノキノリンアミドの直接的触媒的加アルコール分解反応の開発2017

    • Author(s)
      出口亨、辛海龍、森本浩之、大嶋孝志
    • Organizer
      第64回有機金属化学討論会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Boronic Acid-Accelerated Multicomponent Reactions for the Synthesis of α- Substituted Indole-3-acetic Acids2017

    • Author(s)
      Amrita Das, Kenji Watanabe, Hiroyuki Morimoto, and Takashi Ohshima
    • Organizer
      第64回有機金属化学討論会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 改良型亜鉛触媒によるエステル交換反応2017

    • Author(s)
      中武大貴、横手友紀、松嶋義正、矢崎亮、大嶋孝志
    • Organizer
      第34回有機合成化学セミナー
    • Related Report
      2017 Annual Research Report
  • [Presentation] 新規BINOL リン酸触媒を用いた窒素上無保護のα-ケチミノエステルに対する直接的触媒的不斉Friedel-Crafts アルキル化反応の開発2017

    • Author(s)
      近藤優太、米嵜凌平、澤真尚、森崎一宏、森本浩之、大嶋孝志
    • Organizer
      第34回有機合成化学セミナー
    • Related Report
      2017 Annual Research Report
  • [Presentation] The Development of Transformation Reactions of Lower Esters2017

    • Author(s)
      Daiki Nakatake
    • Organizer
      第8回大津会議
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] ベンジル位チオール化反応を用いたpH応答性生体共役反応2017

    • Author(s)
      渡辺賢司、大嶋孝志
    • Organizer
      第35回メディシナルケミストリーシンポジウム
    • Related Report
      2017 Annual Research Report
  • [Presentation] 新規キラルリン酸触媒による窒素上無保護α-ケチミノエステルへの直接的不斉Friedel-Crafts反応の開発2017

    • Author(s)
      米嵜 凌平、近藤 優太、Akkad Walaa、澤 真尚、森崎 一宏、森本 浩之、大嶋 孝志
    • Organizer
      第47回複素環化学討論会
    • Related Report
      2017 Annual Research Report
  • [Presentation] ベンジル位チオール化反応を用いたpH応答性生体共役反応2017

    • Author(s)
      渡辺賢司、大嶋孝志
    • Organizer
      第43回反応と合成の進歩シンポジウム
    • Related Report
      2017 Annual Research Report
  • [Presentation] 8-アミノキノリンアミドの直接的触媒的加アルコール分解反応の開発2017

    • Author(s)
      出口亨、辛海龍、森本浩之、大嶋孝志
    • Organizer
      第43回反応と合成の進歩シンポジウム
    • Related Report
      2017 Annual Research Report
  • [Presentation] 酸素雰囲気下におけるアシルピラゾールの触媒的化学選択的α位酸化反応の開発2017

    • Author(s)
      谷之口誠也、矢崎亮、大嶋孝志
    • Organizer
      第43回反応と合成の進歩シンポジウム
    • Related Report
      2017 Annual Research Report
  • [Presentation] Direct Catalytic Alcoholysis of 8-Aminoquinoline Amides2017

    • Author(s)
      Hai-Long Xin, Toru Deguchi, Hiroyuki Morimoto, Takashi Ohshima
    • Organizer
      第34回 日本薬学会九州支部大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] カルボン酸等価体の触媒的酸化的α-ベンジル化反応2017

    • Author(s)
      田中津久志、橋口佳代子、田中尊書、矢崎亮、大嶋孝志
    • Organizer
      第34回 日本薬学会九州支部大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] ホモカップリング体形成を活用したエノラートの触媒的酸化的クロスカップリング反応の開発2017

    • Author(s)
      田中尊書、田中津久志、矢崎亮、大嶋孝志
    • Organizer
      第112回有機合成シンポジウム 2017年【秋】
    • Related Report
      2017 Annual Research Report
  • [Presentation] 新規BINOLリン酸触媒を用いた窒素上無保護のα-ケチミノエステルに対する直接的触媒的不斉Friedel-Craftsアルキル化反応の開発2016

    • Author(s)
      米嵜凌平、近藤優太、澤真尚、森崎一宏、森本浩之、大嶋孝志
    • Organizer
      第33回日本薬学会九州支部大会
    • Place of Presentation
      鹿児島大学(鹿児島)
    • Year and Date
      2016-12-03
    • Related Report
      2016 Annual Research Report
  • [Presentation] アシルピラゾールの酸素雰囲気下における触媒的化学選択的α位酸化反応2016

    • Author(s)
      谷之口誠也、河上龍馬、矢崎亮、大嶋孝志
    • Organizer
      第33回日本薬学会九州支部大会
    • Place of Presentation
      鹿児島大学(鹿児島)
    • Year and Date
      2016-12-03
    • Related Report
      2016 Annual Research Report
  • [Presentation] ホモカップリング体形成を活用したエノラートの触媒的酸化的クロスカップリング反応の開発2016

    • Author(s)
      田中尊書、田中津久志、矢崎亮、大嶋孝志
    • Organizer
      第33回日本薬学会九州支部大会
    • Place of Presentation
      鹿児島大学(鹿児島)
    • Year and Date
      2016-12-03
    • Related Report
      2016 Annual Research Report
  • [Presentation] アミド型配向基の直接的触媒的加アルコール分解反応の開発2016

    • Author(s)
      出口亨、森本浩之、大嶋孝志
    • Organizer
      第33回日本薬学会九州支部大会
    • Place of Presentation
      鹿児島大学(鹿児島)
    • Year and Date
      2016-12-03
    • Related Report
      2016 Annual Research Report
  • [Presentation] Direct Catalytic Chemoselective α-Amination of Acylpyrazoles: A Concise Route to Unnaturαal α-Amino Acid Derivatives2016

    • Author(s)
      Takashi Ohshima, Ryo Yazaki, Keisuke Tokumasu
    • Organizer
      International Symposium on Catalysis and Fine Chemicals (C&FC2016)
    • Place of Presentation
      Howard Civil Service International House (Taipei)
    • Year and Date
      2016-11-10
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] α-ケチミノエステルおよび無保護ケチミンに対する直接的触媒的アルキニル化反応の開発2016

    • Author(s)
      森本浩之、森崎一宏、澤真尚、米嵜凌平、真島和志、大嶋孝志
    • Organizer
      第42回反応と合成の進歩シンポジウム
    • Place of Presentation
      静岡市清水文化会館マリナート(静岡)
    • Year and Date
      2016-11-07
    • Related Report
      2016 Annual Research Report
  • [Presentation] ホモカップリング体形成を経たエノラートの触媒的かつ酸化的クロスカップリング反応の開発2016

    • Author(s)
      田中尊書、田中津久志、矢崎亮、大嶋孝志
    • Organizer
      第42回反応と合成の進歩シンポジウム
    • Place of Presentation
      静岡市清水文化会館マリナート(静岡)
    • Year and Date
      2016-11-07
    • Related Report
      2016 Annual Research Report
  • [Presentation] Zn-Catalyzed Direct Alkynylation of N-Unprotected Trifluoromethyl Ketimine2016

    • Author(s)
      Takashi Ohshima, Kazuhiro Morisaki, Hiroyuki Morimoto
    • Organizer
      The 11th International Conference on Cutting-Edge Organic Chemistry in Asia (ICCEOCA-11) & The 2nd Advanced Research Network on Cutting-Edge Organic Chemistry in Asia (ARNCEOCA-2)
    • Place of Presentation
      KAIST, Daejeon (Korea)
    • Year and Date
      2016-10-27
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Zn-Catalyzed Direct Alkynylation of N-Unprotected Trifluoromethyl Ketimines2016

    • Author(s)
      Kazuhiro Morisaki, Hiroyuki Morimoto, Takashi Ohshima
    • Organizer
      The 6th Junior International Conference on Cutting-edge Organic Chemistry in Asia (6th Junior ICCEOCA)
    • Place of Presentation
      Chikushi campus of Kyushu University, Fukuoka
    • Year and Date
      2016-10-24
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Transesterification Reactions Promoted by Newly Developed Zinc Catalysts2016

    • Author(s)
      Daiki Nakatake, Yuki Yokote, Yoshimasa Matsushima, Ryo Yazaki, Takashi Ohshima
    • Organizer
      The 6th Junior International Conference on Cutting-edge Organic Chemistry in Asia (6th Junior ICCEOCA)
    • Place of Presentation
      Chikushi campus of Kyushu University, Fukuoka
    • Year and Date
      2016-10-24
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] アシルピラゾールの酸素雰囲気下における触媒的化学選択的α位酸化反応2016

    • Author(s)
      谷之口誠也、河上龍馬、矢崎亮、大嶋孝志
    • Organizer
      第46回複素環化学討論会
    • Place of Presentation
      金沢歌劇座(石川)
    • Year and Date
      2016-09-26
    • Related Report
      2016 Annual Research Report
  • [Presentation] 触媒的化学選択的α-アミノ酸及びヒドロキシ酸誘導体合成2016

    • Author(s)
      矢崎亮、谷之口誠也、徳益圭祐、大嶋孝志
    • Organizer
      第63回有機金属化学討論会
    • Place of Presentation
      早稲田大学西早稲田キャンパス(東京)
    • Year and Date
      2016-09-14
    • Related Report
      2016 Annual Research Report
  • [Presentation] 亜鉛触媒によるN無保護トリフルオロメチルケトイミンに対する直接的アルキニル化反応2016

    • Author(s)
      森崎一宏、森本浩之、大嶋孝志
    • Organizer
      第63回有機金属化学討論会
    • Place of Presentation
      早稲田大学西早稲田キャンパス(東京)
    • Year and Date
      2016-09-14
    • Related Report
      2016 Annual Research Report
  • [Presentation] 改良型亜鉛触媒によるエステル交換反応2016

    • Author(s)
      中武大貴・横手友紀・矢崎亮・大嶋孝志
    • Organizer
      第63回有機金属化学討論会
    • Place of Presentation
      早稲田大学西早稲田キャンパス(東京)
    • Year and Date
      2016-09-14
    • Related Report
      2016 Annual Research Report
  • [Presentation] Development of oxidative Heck reaction for derivatizing complex molecules and reactivity study of heteroarenes2016

    • Author(s)
      Das Amrita, Takumi Kimijima, Kenji Watanabe, Makoto Tsuda and Takashi Ohshima
    • Organizer
      第33回有機合成化学セミナー
    • Place of Presentation
      ヒルトンニセコビレッジ(北海道)
    • Year and Date
      2016-09-06
    • Related Report
      2016 Annual Research Report
  • [Presentation] ロジウム触媒を用いたケチミンに対する直接的触媒的不斉アルキニ ル化反応の反応機構解析及びに基質一般性の拡大2016

    • Author(s)
      米嵜凌平、森崎一宏、澤真尚、森本浩之、真島和志、大嶋孝志
    • Organizer
      第33回有機合成化学セミナー
    • Place of Presentation
      ヒルトンニセコビレッジ(北海道)
    • Year and Date
      2016-09-06
    • Related Report
      2016 Annual Research Report
  • [Presentation] Rhodium-Catalyzed Direct Enantioselective Alkynylation of Ketimines: Mechanistic Studies and Expansion of Substrate Generality2016

    • Author(s)
      Takashi Ohshima
    • Organizer
      The 3rd International Conference on Organometallics and Catalysis 2016 (OM&Cat-2016)
    • Place of Presentation
      Hoam Convention Center (Seoul National University) (Korea)
    • Year and Date
      2016-08-28
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Development and mechanistic studies of Rh-catalyzed direct enantioselective alkynylation of α-ketiminoesters2016

    • Author(s)
      Kazuhiro Morisaki, Hiroyuki Morimoto, Takashi Ohshima
    • Organizer
      252nd American Chemical Society National Meeting & Exposition
    • Place of Presentation
      Pennsylvania Convention Center(USA)
    • Year and Date
      2016-08-21
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Direct Catalytic Chemoselective α-Amination of Acylpyrazoles: A Concise Route to Unnatural α-Amino Acid Derivatives2016

    • Author(s)
      Takashi Ohshima
    • Organizer
      International Symposium on Pure & Applied Chemistry (ISPAC2016)
    • Place of Presentation
      Borneo Convention Centre Kuching, Kuching, Sarawak, (Malaysia)
    • Year and Date
      2016-08-16
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 高活性鉄触媒によるエステル交換反応の開発2016

    • Author(s)
      堀河力也、藤本千佳、田中尊書、矢崎亮、大嶋孝志
    • Organizer
      日本プロセス化学会 2016サマーシンポジウム
    • Place of Presentation
      名古屋国際会議場(愛知)
    • Year and Date
      2016-07-28
    • Related Report
      2016 Annual Research Report
  • [Presentation] Direct Catalytic Asymmetric Nucleophilic Addition of Ketimines2016

    • Author(s)
      Sawa Masanao
    • Organizer
      野依フォーラム若手育成塾
    • Place of Presentation
      名古屋大学野依記念館(愛知)
    • Year and Date
      2016-07-21
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Direct Catalytic Chemoselective α-Amination of Acylpyrazoles2016

    • Author(s)
      Takashi Ohshima, Ryo Yazaki, Keisuke Tokumasu
    • Organizer
      The 27th International Conference on Organometallic Chemistry (ICOMC 2016)
    • Place of Presentation
      Melbourne Convention and Exhibition Centre (Australia)
    • Year and Date
      2016-07-17
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Catalytic Hydroxy Group-selective Conjugate Addition of Unprotected Aminoalcohols2016

    • Author(s)
      Zhao Li, Ryo Yazaki, Takashi Ohshima
    • Organizer
      The 27th International Conference on Organometallic Chemistry (ICOMC 2016)
    • Place of Presentation
      Melbourne Convention and Exhibition Centre (Australia)
    • Year and Date
      2016-07-17
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] ホモカップリング体形成を経たエノラートの触媒的かつ酸化的クロスカップリング反応の開発2016

    • Author(s)
      田中尊書、田中津久志、矢崎亮、大嶋孝志
    • Organizer
      第49回 有機金属若手の会 夏の学校
    • Place of Presentation
      東海大学嬬恋高原研修センター(群馬)
    • Year and Date
      2016-07-11
    • Related Report
      2016 Annual Research Report
  • [Presentation] 銅触媒を用いた空気雰囲気下におけるカルボン酸誘導体の化学選択的α位酸化反応2016

    • Author(s)
      谷之口誠也、矢崎亮、大嶋孝志
    • Organizer
      第49回 有機金属若手の会 夏の学校
    • Place of Presentation
      東海大学嬬恋高原研修センター(群馬)
    • Year and Date
      2016-07-11
    • Related Report
      2016 Annual Research Report
  • [Presentation] ロジウム触媒によるα-ケチミノエステルに対する直接的触媒的不斉アルキニル化反応の反応機構解析2016

    • Author(s)
      森崎一宏、澤真尚、米嵜凌平、森本浩之、真島和志、大嶋孝志
    • Organizer
      第49回 有機金属若手の会 夏の学校
    • Place of Presentation
      東海大学嬬恋高原研修センター(群馬)
    • Year and Date
      2016-07-11
    • Related Report
      2016 Annual Research Report
  • [Presentation] Dinuclear Iron(III) Catalyzed O-Selective Acylation of Aliphatic and Aromatic Amino Alcohols and Transesterification of tert-Alcohols2016

    • Author(s)
      Takashi Ohshima
    • Organizer
      The International Symposium on Homogeneous Catalysis (ISHC) 2016
    • Place of Presentation
      Kyoto Terrsa (Kyoto)
    • Year and Date
      2016-07-10
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Synthesis of α-Amino Acid by Catalytic and Chemoselective α-Amination2016

    • Author(s)
      Keisuke Tokumasu, Ryo Yazaki, Takashi Ohshima
    • Organizer
      The International Symposium on Homogeneous Catalysis (ISHC) 2016
    • Place of Presentation
      Kyoto Terrsa (Kyoto)
    • Year and Date
      2016-07-10
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 触媒的化学選択的アミノ化反応によるα-アミノ酸合成2016

    • Author(s)
      矢崎 亮、徳益 圭祐、大嶋 孝志
    • Organizer
      第109回有機合成シンポジウム
    • Place of Presentation
      東京工業大学(東京)
    • Year and Date
      2016-06-08
    • Related Report
      2016 Annual Research Report
  • [Presentation] Environmentally Friendly Ester Synthesis Reactions Catalyzed by Developed Zinc Catalysts2016

    • Author(s)
      中武大貴、松嶋義正、矢崎亮、大嶋孝志
    • Organizer
      5th JACI/GSCシンポジウム
    • Place of Presentation
      ANAクラウンプラザホテル神戸(兵庫)
    • Year and Date
      2016-06-02
    • Related Report
      2016 Annual Research Report
  • [Presentation] Chemoselective Catalytic Conjugate Addition of Hydroxy Group over Amino Group2016

    • Author(s)
      Zhao Li, Shuhei Uesugi, Ryo Yazaki, Takashi Ohshima
    • Organizer
      第14回次世代を担う有機化学シンポジウム
    • Place of Presentation
      日本薬学会長井記念ホール(東京)
    • Year and Date
      2016-05-27
    • Related Report
      2016 Annual Research Report
  • [Presentation] μ-Oxo-Dinuclear Iron(III) Catalyzed O-Selective Acylation of Aliphatic and Aromatic Amino Alcohols and Transesterification of tert-Alcohols2016

    • Author(s)
      Takashi Ohshima, Rikiya Horikawa, Chika Fujimoto, Ryo Yazaki
    • Organizer
      French-Japanese Society of Medicinal and Fine Chemistry (FJS2016)
    • Place of Presentation
      Keio Plaza Hotel Tama(Tokyo)
    • Year and Date
      2016-05-15
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Direct Catalytic Chemoselective α-Amination of Acylpyrazoles: A Concise Route to Unnatuαal α-Amino Acid Derivatives2016

    • Author(s)
      Takashi Ohshima, Ryo Yazaki, Keisuke Tokumasu
    • Organizer
      The 12th International Symposium on Organic Reactions and The 6th German-Japanese Symposium on Electrosynthesis (ISOR-12 and GJSE-6)
    • Place of Presentation
      Kyoto Terrsa(Kyoto)
    • Year and Date
      2016-04-22
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Development of A Highly Active Iron Catalyst for Transesterification2016

    • Author(s)
      Rikiya Horikawa, Chika Fujimoto, Takafumi Tanaka, Ryo Yazaki and Takashi Ohshima
    • Organizer
      The 12th International Symposium on Organic Reactions and The 6th German-Japanese Symposium on Electrosynthesis (ISOR-12 and GJSE-6)
    • Place of Presentation
      Kyoto Terrsa(Kyoto)
    • Year and Date
      2016-04-22
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Direct Catalytic Asymmetric Alkynylation of Ketimines2016

    • Author(s)
      Sawa Masanao、Morisaki Kazuhiro、Yonesaki Ryohei、Morimoto Hiroyuki、Mashima Kazushi、Ohshima Takashi
    • Organizer
      Molecular Chirality Asia 2016
    • Place of Presentation
      Knowledge Capital Congress Convention Center(大阪)
    • Year and Date
      2016-04-20
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] アンモニアとアリルアルコールの触媒的直接返還反応による一級アリルアミンの合成法の開発2016

    • Author(s)
      澁谷亮三、リン ルー、大嶋孝志
    • Organizer
      日本薬学会第136年会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2016-03-26
    • Related Report
      2015 Annual Research Report
  • [Presentation] Catalytic β-amino alcohol selective reaction in the presence of other amino alcohol2016

    • Author(s)
      Zhao Li, Ryo Yazaki, Takashi Ohshima
    • Organizer
      日本薬学会第136年会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2016-03-26
    • Related Report
      2015 Annual Research Report
  • [Presentation] Development of Oxidative Heck Reaction for the Late-Stage C-H Functionalization of Bioactive Compounds2016

    • Author(s)
      Das Amrita, Takumi Kimijima, Kenji Watanabe, Makoto Tsuda, Takashi Ohshima
    • Organizer
      日本薬学会第136年会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2016-03-26
    • Related Report
      2015 Annual Research Report
  • [Presentation] エステル交換反応に用いる新規亜鉛担持固相触媒の開発2016

    • Author(s)
      中武大貴、松嶋義正、矢崎亮、大嶋孝志
    • Organizer
      日本薬学会第136年会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2016-03-26
    • Related Report
      2015 Annual Research Report
  • [Presentation] 銅触媒を用いたカルボン酸等価体の直接的化学選択的α位アミノ化によるαアミノ酸合成2016

    • Author(s)
      徳益圭祐、矢崎亮、大嶋孝志
    • Organizer
      日本薬学会第136年会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2016-03-26
    • Related Report
      2015 Annual Research Report
  • [Presentation] Development of Oxidative Coupling Reaction for Late-Stage Functionalization of Complex Molecules2016

    • Author(s)
      Kenji Watanabe, Takumi Kimijima, Amrita DAS, Makoto Tsuda, Takashi Ohshima
    • Organizer
      日本化学会第96春季年会(2016)
    • Place of Presentation
      同志社大学 京田辺キャンパス
    • Year and Date
      2016-03-24
    • Related Report
      2015 Annual Research Report
  • [Presentation] Catalytic Chemoselective Designed Reactions2016

    • Author(s)
      矢崎 亮
    • Organizer
      新学術領域研究「反応集積化が導く中分子戦略:高次生物機能分子の創製」第一回若手の会
    • Place of Presentation
      神戸市国民宿舎須磨荘シーパル須磨
    • Year and Date
      2016-03-11
    • Related Report
      2015 Annual Research Report
  • [Presentation] 工業応用を志向した改良型亜鉛触媒によるエステル交換反応2016

    • Author(s)
      中武大貴、横手友紀、松嶋義正、矢崎亮、大嶋孝志
    • Organizer
      第26回万有福岡シンポジウム
    • Place of Presentation
      九州大学医学部百年講堂(福岡)
    • Related Report
      2016 Annual Research Report
  • [Presentation] 工業応用を志向した改良型亜鉛触媒によるエステル交換反応2016

    • Author(s)
      中武大貴、横手友紀、松嶋義正、矢崎亮、大嶋孝志
    • Organizer
      第28回 万有札幌シンポジウム
    • Place of Presentation
      北海道大学工学部(北海道)
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] New Zinc and Iron Catalysts for Transesterification2016

    • Author(s)
      Takashi Ohshima
    • Organizer
      The 2nd International Symposium on Middle Molecular Strategy(ISMMS-2)
    • Place of Presentation
      千里ライフサイエンスセンター(大阪)
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] アミド型配向基の直接的触媒的加アルコール分解反応の開発2016

    • Author(s)
      出口亨、森本浩之、大嶋孝志
    • Organizer
      第53回化学関連支部合同九州大会
    • Place of Presentation
      北九州国際会議場(福岡)
    • Related Report
      2016 Annual Research Report
  • [Presentation] ホモカップリング体形成を経たエノラートの触媒的かつ酸化的クロスカップリング反応の開発2016

    • Author(s)
      田中尊書、田中津久志、矢崎亮、大嶋孝志
    • Organizer
      第53回化学関連支部合同九州大会
    • Place of Presentation
      北九州国際会議場(福岡)
    • Related Report
      2016 Annual Research Report
  • [Presentation] アシルピラゾールの酸素雰囲気下における触媒的化学選択的α位酸化反応2016

    • Author(s)
      谷之口誠也、矢崎亮、大嶋孝志
    • Organizer
      第53回化学関連支部合同九州大会
    • Place of Presentation
      北九州国際会議場(福岡)
    • Related Report
      2016 Annual Research Report
  • [Presentation] アミド型配向基の直接的触媒的加アルコール分解反応の開発2016

    • Author(s)
      出口亨、森本浩之、大嶋孝志
    • Organizer
      第28回若手研究者のためのセミナー
    • Place of Presentation
      九州大学伊都キャンパス(福岡)
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] ホモカップリング体形成を経たエノラートの触媒的かつ酸化的クロスカップリング反応の開発2016

    • Author(s)
      田中尊書、田中津久志、矢崎亮、大嶋孝志
    • Organizer
      第28回若手研究者のためのセミナー
    • Place of Presentation
      九州大学伊都キャンパス(福岡)
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Catalytic Chemoselective Conjugate Addition of Alcohol over Amine2016

    • Author(s)
      Takashi Ohshima
    • Organizer
      The 2nd HU-TMU-KU Joint Symposium for Pharmaceutical Sciences
    • Place of Presentation
      Taipei Medical University (Taiwan)
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 高活性鉄触媒によるエステル交換反応の開発2016

    • Author(s)
      堀河力也、藤本千佳、田中尊書、矢崎亮、大嶋孝志
    • Organizer
      日本プロセス化学会2016ウインターシンポジウム
    • Place of Presentation
      タワーホール船堀(東京)
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 触媒機能を研ぐ反応機構解析2016

    • Author(s)
      大嶋孝志
    • Organizer
      第二回魚住触媒研究会
    • Place of Presentation
      分子科学研究所山手キャンパス(岡崎)
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Dinuclear iron complex-catalyzed transesterification: Synthesis of tert-butyl esters and unprecedented chemoselectivity2015

    • Author(s)
      T. Ohshima, R. Horikawa, C. Fujimoto, R. Yazaki
    • Organizer
      The 2015 International Chemical Congress of Pacific Basin Societies (Pacifichem)
    • Place of Presentation
      Hilton Hawaiian Village (Hawaii, USA)
    • Year and Date
      2015-12-15
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Rhodium-Catalyzed Direct Enantioselective Alkynylation of Ketimines: Mechanistic Studies and Expansion of Substrate Generality2015

    • Author(s)
      T. Ohshima, K. Morisaki, M. Sawa, R. Yonesaki, H. Morimoto
    • Organizer
      The 2015 International Chemical Congress of Pacific Basin Societies (Pacifichem)
    • Place of Presentation
      Hilton Hawaiian Village (Hawaii, USA)
    • Year and Date
      2015-12-15
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Catalytic chemoselective conjugate addition of alcohols over amines2015

    • Author(s)
      Ryo Yazaki, Shuhei Uesugi, Zhao Li, Takashi Ohshima
    • Organizer
      The 2015 International Chemical Congress of Pacific Basin Societies (Pacifichem)
    • Place of Presentation
      Hawaii Convention Center (Hawaii, USA)
    • Year and Date
      2015-12-15
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Cleavage of Unactivated Amide Bonds by Ammonium Salt-Accelerated Hydrazinolysis2015

    • Author(s)
      Yuhei Shimizu, Megumi Noshita, Yuri Mukai, Hiroyuki Morimoto, Takashi Ohshima
    • Organizer
      The 2015 International Chemical Congress of Pacific Basin Societies (Pacifichem)
    • Place of Presentation
      Hawaii Convention Center (Hawaii, USA)
    • Year and Date
      2015-12-15
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Direct catalytic conversion of ammonia and allylic alcohols to primary allylamines at room temperature2015

    • Author(s)
      Ryozo Shibuya, Lu Lin, Takashi Ohshima
    • Organizer
      The 2015 International Chemical Congress of Pacific Basin Societies (Pacifichem)
    • Place of Presentation
      Hawaii Convention Center (Hawaii, USA)
    • Year and Date
      2015-12-15
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 官能基の活性化および保護化フリーのプロセスを可能とする直接的触媒反応の開発2015

    • Author(s)
      大嶋孝志
    • Organizer
      第75回白鷺セミナー
    • Place of Presentation
      大阪府立大学(理学部サイエンスホール)
    • Year and Date
      2015-12-02
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 遷移金属触媒によるアリルアルコールとアリルアミンの化学選択的置換反応の開発2015

    • Author(s)
      LIN Lu、澁谷亮三、大嶋孝志
    • Organizer
      第32回日本薬学会九州支部大会
    • Place of Presentation
      九州保健福祉大学
    • Year and Date
      2015-11-28
    • Related Report
      2015 Annual Research Report
  • [Presentation] アンモニウム塩加速効果を活用したアミド切断反応の開発とフロー系への適用2015

    • Author(s)
      野下めぐみ, 清水悠平, 森本浩之, 赤井周司, 大根田訓之, 小田島博道, 村松賢, 大嶋孝志
    • Organizer
      第32回日本薬学会九州支部大会
    • Place of Presentation
      九州保健福祉大学
    • Year and Date
      2015-11-28
    • Related Report
      2015 Annual Research Report
  • [Presentation] 触媒的化学選択的αアミノ化反応によるαアミノ酸合成2015

    • Author(s)
      徳益圭祐、矢崎亮、大嶋孝志
    • Organizer
      第32回日本薬学会九州支部大会
    • Place of Presentation
      九州保健福祉大学
    • Year and Date
      2015-11-28
    • Related Report
      2015 Annual Research Report
  • [Presentation] 複雑な生理活性化合物のlate-stage functionalizationを指向した酸化的カップリング反応の開発と創薬研究への応用2015

    • Author(s)
      渡辺賢司、君島匠、Das Amrita、津田誠、大嶋孝志
    • Organizer
      第33回メディシナルケミストリーシンポジウム
    • Place of Presentation
      千葉幕張国際研修センター
    • Year and Date
      2015-11-25
    • Related Report
      2015 Annual Research Report
  • [Presentation] Catalytic hydroxyl group-selective conjugate addition of unprotected amino alcohols2015

    • Author(s)
      Zhao Li・Ryo Yazaki・Takashi Ohshima
    • Organizer
      第45回複素環化学討論会
    • Place of Presentation
      早稲田大学国際会議場
    • Year and Date
      2015-11-19
    • Related Report
      2015 Annual Research Report
  • [Presentation] 官能基の活性化および保護化フリーのプロセスを可能とする直接的触媒反応の開発2015

    • Author(s)
      大嶋孝志
    • Organizer
      第30回農薬デザイン研究会 ~環境調和を志向した農薬デザイン~
    • Place of Presentation
      メルパルク京都
    • Year and Date
      2015-11-12
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 高活性鉄触媒によるエステル交換反応の開発2015

    • Author(s)
      堀河力也、田中尊書、藤本千佳、矢崎亮、大嶋孝志
    • Organizer
      第108回有機合成シンポジウム2015年【秋】
    • Place of Presentation
      早稲田大学国際会議場
    • Year and Date
      2015-11-05
    • Related Report
      2015 Annual Research Report
  • [Presentation] Direct Catalytic Chemoselective Amination: A Concise Route to α-Amino Acid Derivatives2015

    • Author(s)
      Takashi Ohshima
    • Organizer
      第10回アジア最先端有機化学国際会議 The 10th International Conference on Cutting-edge Organic Chemistry in Asia (ICCEOCA-10)
    • Place of Presentation
      SKY TOWER HOTEL in Kaohsiung (Taiwan)
    • Year and Date
      2015-11-02
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Direct Catalytic Enantioselective Alkynylation of Ketimines2015

    • Author(s)
      Kazuhiro Morisaki, Masanao Sawa, Ryohei Yonesaki, Jun-ya Nomaguchi, Yousuke Takeuchi, Hiroyuki Morimoto, Kazushi Mashima, Takashi Ohshima
    • Organizer
      第5回ジュニア国際有機化学シンポジウムThe 5th Junior International Conference on Cutting-edge Organic Chemistry in Asia (5th Junior ICCEOCA)
    • Place of Presentation
      85 Sky Tower Hotel (Taiwan)
    • Year and Date
      2015-10-30
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 含窒素複素環配位子を用いた新規亜鉛触媒の開発2015

    • Author(s)
      中武大貴、横手友紀、矢崎亮、大嶋孝志
    • Organizer
      第41回反応と合成の進歩シンポジウム
    • Place of Presentation
      近畿大学 11月ホール
    • Year and Date
      2015-10-26
    • Related Report
      2015 Annual Research Report
  • [Presentation] Late-Stage C-H Functionalizationを基盤とする環境調和型創薬研究2015

    • Author(s)
      渡辺賢司、君島匠、Das Amrita、津田誠、大嶋孝志
    • Organizer
      第41回反応と合成の進歩シンポジウム
    • Place of Presentation
      近畿大学 11月ホール
    • Year and Date
      2015-10-26
    • Related Report
      2015 Annual Research Report
  • [Presentation] イミノヨージナンを用いた触媒的化学選択的アミノ化反応によるα-アミノ酸合成2015

    • Author(s)
      矢崎亮、徳益圭祐、大嶋孝志
    • Organizer
      第18回ヨウ素学会シンポジウム
    • Place of Presentation
      千葉大学西千葉キャンパス総合校舎
    • Year and Date
      2015-09-16
    • Related Report
      2015 Annual Research Report
  • [Presentation] 天然物及び医薬品化合物のlate-stage C-H functionalizationを指向した反応開発2015

    • Author(s)
      渡辺賢司、君島匠、Das Amrita、津田誠、大嶋孝志
    • Organizer
      第57回天然有機化合物討論会
    • Place of Presentation
      神奈川県民ホール
    • Year and Date
      2015-09-09
    • Related Report
      2015 Annual Research Report
  • [Presentation] 触媒的化学選択的アミノ化反応によるα-アミノ酸合成2015

    • Author(s)
      矢崎亮、徳益圭介、大嶋孝志
    • Organizer
      第62回有機金属化学討論会
    • Place of Presentation
      関西大学千里山キャンパス
    • Year and Date
      2015-09-07
    • Related Report
      2015 Annual Research Report
  • [Presentation] Catalytic Hydroxyl Group Selective Conjugate Addition of Unprotected Amino Alcohols2015

    • Author(s)
      Zhao Li, Ryo Yazaki, Takashi Ohshima
    • Organizer
      第62回有機金属化学討論会
    • Place of Presentation
      関西大学千里山キャンパス
    • Year and Date
      2015-09-07
    • Related Report
      2015 Annual Research Report
  • [Presentation] Late-stage C-H functionalizationを指向した酸化的Heck反応の開発及び複雑な基質への適応2015

    • Author(s)
      君島匠、Das Amrita、渡辺賢司、津田誠、大嶋孝志
    • Organizer
      第62回有機金属化学討論会
    • Place of Presentation
      関西大学千里山キャンパス
    • Year and Date
      2015-09-07
    • Related Report
      2015 Annual Research Report
  • [Presentation] Development of A Highly Active Iron Catalyst for Transesterification2015

    • Author(s)
      Rikiya Horikawa, Chika Fujimoto, Ryo Yazaki, Takashi Ohshima
    • Organizer
      The 3rd International Symposium on Process Chemistry ( ISPC 2015)
    • Place of Presentation
      Kyoto International Conference Center
    • Year and Date
      2015-07-13
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Direct Catalytic Asymmetric Alkynylation of Ketimines2015

    • Author(s)
      Sawa Masanao, Morisaki Kazuhiro, Yonesaki Ryohei, Morimoto Hiroyuki, Mashima Kazushi, Ohshima Takashi
    • Organizer
      7th International Conference on Green and Sustainable Chemistry - 4th JACI-GSC Symposium(第4回 JACI/GSCシンポジウム)
    • Place of Presentation
      一橋大学
    • Year and Date
      2015-07-05
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Catalytic Chemoselective Conjugate Addition of Alcohol over Amine2015

    • Author(s)
      Takashi Ohshima
    • Organizer
      the 18th IUPAC International Symposium on Organometallic Chemistry Directed Towards Organic Synthesis (OMCOS 18)
    • Place of Presentation
      Hotel Melia Sitges(Barcelona, Spain)
    • Year and Date
      2015-07-02
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Book] New Horizons of Process Chemistry2017

    • Author(s)
      Ohshima, Takashi
    • Publisher
      Springer, Singapore
    • Related Report
      2017 Annual Research Report
  • [Book] 銅触媒によるカルボン酸等価体のα位官能基化反応の開発2017

    • Author(s)
      11.大嶋孝志
    • Publisher
      JETI
    • Related Report
      2017 Annual Research Report
  • [Remarks] 九州大学大学院薬学研究院 環境調和創薬化学分野

    • URL

      http://green.phar.kyushu-u.ac.jp

    • Related Report
      2018 Annual Research Report
  • [Remarks] 九州大学先生の森

    • URL

      https://www.kyushu-u.ac.jp/ja/university/professor/oshima.html

    • Related Report
      2018 Annual Research Report
  • [Remarks] 九州大学大学院薬学研究院 環境調和創薬化学分野

    • URL

      http://green.phar.kyushu-u.ac.jp/

    • Related Report
      2017 Annual Research Report
  • [Remarks] 九州大学大学院薬学研究院 環境調和創薬化学分野

    • URL

      http://green.phar.kyushu-u.ac.jp/index.html

    • Related Report
      2016 Annual Research Report
  • [Remarks] 九州大学大学院薬学研究院 環境調和創薬化学分野

    • URL

      http://green.phar.kyushu-u.ac.jp/index.html

    • Related Report
      2015 Annual Research Report
  • [Patent(Industrial Property Rights)] 窒素上無保護イミン化合物の製造方法2019

    • Inventor(s)
      大嶋孝志、森本浩 之、森崎一宏、近藤 優太
    • Industrial Property Rights Holder
      大嶋孝志、森本浩 之、森崎一宏、近藤 優太
    • Industrial Property Rights Type
      特許
    • Filing Date
      2019
    • Related Report
      2018 Annual Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] 窒素上無保護イミン化合物の合成方法2018

    • Inventor(s)
      大嶋孝志、森本浩之、森崎一宏、近藤優太
    • Industrial Property Rights Holder
      大嶋孝志、森本浩之、森崎一宏、近藤優太
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2018-082703
    • Filing Date
      2018
    • Related Report
      2017 Annual Research Report

URL: 

Published: 2015-07-02   Modified: 2019-12-27  

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