| Budget Amount *help |
¥45,500,000 (Direct Cost: ¥35,000,000、Indirect Cost: ¥10,500,000)
Fiscal Year 2019: ¥8,840,000 (Direct Cost: ¥6,800,000、Indirect Cost: ¥2,040,000)
Fiscal Year 2018: ¥8,840,000 (Direct Cost: ¥6,800,000、Indirect Cost: ¥2,040,000)
Fiscal Year 2017: ¥8,840,000 (Direct Cost: ¥6,800,000、Indirect Cost: ¥2,040,000)
Fiscal Year 2016: ¥8,840,000 (Direct Cost: ¥6,800,000、Indirect Cost: ¥2,040,000)
Fiscal Year 2015: ¥10,140,000 (Direct Cost: ¥7,800,000、Indirect Cost: ¥2,340,000)
|
|---|
| Outline of Final Research Achievements |
To develop a large-scale supply method for middle-molecule functional compounds, such as pharmaceuticals, we researched to create a new method of integrating environmentally friendly catalytic reactions and controling chemoselectivity in a catalytic manner.
After five years of research, we succeeded in developing α-functionalization of carboxylic acid equivalents, chemoselective catalytic conjugate addition reaction, transesterification of t-alcohol, benzylic thiolation reaction under weakly acidic conditions, cross-cross coupling reaction between different enolates, dehydrogenative benzylation of carboxylic acid equivalents, direct catalytic α-functionalization of carboxylic acid, novel synthetic method of sterically large unnatural α-amino acid, amide bond cleavage reaction using flow-microwave system, ene reaction using flow*microwave system, etc., and performed middle molecule synthesis of pharmaceutical compounds.
|
