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Integration of Ionic Reactions

Planned Research

Project AreaMiddle molecular strategy: Creation of higher bio-functional molecules by integrated synthesis.
Project/Area Number 15H05849
Research Category

Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

Allocation TypeSingle-year Grants
Review Section Science and Engineering
Research InstitutionKyoto University

Principal Investigator

NAGAKI AIICHIRO  京都大学, 工学研究科, 准教授 (80452275)

Co-Investigator(Kenkyū-buntansha) 吉田 潤一  京都大学, 工学研究科, 教授 (30127170)
Project Period (FY) 2015-06-29 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥45,500,000 (Direct Cost: ¥35,000,000、Indirect Cost: ¥10,500,000)
Fiscal Year 2019: ¥8,840,000 (Direct Cost: ¥6,800,000、Indirect Cost: ¥2,040,000)
Fiscal Year 2018: ¥8,840,000 (Direct Cost: ¥6,800,000、Indirect Cost: ¥2,040,000)
Fiscal Year 2017: ¥8,840,000 (Direct Cost: ¥6,800,000、Indirect Cost: ¥2,040,000)
Fiscal Year 2016: ¥8,840,000 (Direct Cost: ¥6,800,000、Indirect Cost: ¥2,040,000)
Fiscal Year 2015: ¥10,140,000 (Direct Cost: ¥7,800,000、Indirect Cost: ¥2,340,000)
Keywordsマイクロリアクター / アニオン反応 / カチオン反応 / アニオン活性種 / 反応集積化 / アニオン重合
Outline of Final Research Achievements

An integration of chemical reactions which assembled a new direct and efficient molecular conversion method was done aiming to synthesize various useful molecules precisely and quickly. Not only can organic synthesis via short-life active species such as anionic intermediates and cationic intermediates be dramatically accelerated, but also utilized the features of reaction integration. For this purpose, we have created a new method for reaction integration by classifying the reaction integration into linear integrated synthesis and convergent integrated synthesis types using flow microreactor. Therefore, we have established a high-efficiency synthesis method for middle molecules.

Academic Significance and Societal Importance of the Research Achievements

複数のフローマイクロリアクターを連続的に配置する空間的反応集積化により、「反応集積化の合成化学」という手法は、複数の化学反応を時間的・空間的に結合させることにより、直截的かつ効率的な分子変換法を確立できた。フローマイクロリアクターは、活性種制御のための「時間を空間で制御する合成化学」を達成し、また、空間的反応集積化による「反応集積化の合成化学」、を実現する上で必須のツールであり、機能中分子の実用的な合成の極めて効果的である。今後、合成化学の学術水準の飛躍的向上・強化に繋がるだけでなく、新物質創成を通じて医学・薬学・材料科学等の広範な分野に大きく貢献できると期待される。

Report

(6 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Annual Research Report
  • 2017 Annual Research Report
  • 2016 Annual Research Report
  • 2015 Annual Research Report
  • Research Products

    (99 results)

All 2020 2019 2018 2017 2016 2015 Other

All Journal Article (43 results) (of which Int'l Joint Research: 5 results,  Peer Reviewed: 38 results,  Open Access: 23 results,  Acknowledgement Compliant: 6 results) Presentation (46 results) (of which Int'l Joint Research: 18 results,  Invited: 35 results) Book (8 results) Remarks (2 results)

  • [Journal Article] Continuous Production Using a T-Shaped Micro/Milli-Reactor for RUCY-Catalyzed Asymmetric Hydrogenation of Acetophenone2020

    • Author(s)
      Yamamoto Tetsuya、Tonomura Osamu、Nagaki Aichiro
    • Journal Title

      JOURNAL OF CHEMICAL ENGINEERING OF JAPAN

      Volume: 53 Issue: 2 Pages: 73-77

    • DOI

      10.1252/jcej.19we083

    • NAID

      130007800544

    • ISSN
      0021-9592, 1881-1299
    • Year and Date
      2020-02-20
    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Synthesis of Biaryls Having a Piperidylmethyl Group Based on Space Integration of Lithiation, Borylation, and Suzuki-Miyaura Coupling2020

    • Author(s)
      Takahashi Yusuke、Ashikari Yosuke、Takumi Masahiro、Shimizu Yutaka、Jiang Yiyuan、Higuma Ryosuke、Ishikawa Susumu、Sakaue Hodaka、Shite Ibuki、Maekawa Kei、Aizawa Yoko、Yamashita Hiroki、Yonekura Yuya、Colella Marco、Luisi Renzo、Takegawa Toshihiro、Fujita Chiemi、Nagaki Aiichiro
    • Journal Title

      European Journal of Organic Chemistry

      Volume: 2020 Issue: 5 Pages: 618-622

    • DOI

      10.1002/ejoc.201901729

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Tf2O-mediated Reaction of Alkenyl Sulfoxides with Unprotected Anilines in Flow Microreactors2020

    • Author(s)
      Baralle Alexandre、Inukai Tomoaki、Yanagi Tomoyuki、Nogi Keisuke、Osuka Atsuhiro、Nagaki Aiichiro、Yoshida Jun-ichi、Yorimitsu Hideki
    • Journal Title

      Chemistry Letters

      Volume: 49 Issue: 2 Pages: 160-163

    • DOI

      10.1246/cl.190831

    • NAID

      130007795212

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] A Novel Approach to Functionalization of Aryl Azides through the Generation and Reaction of Organolithium Species Bearing Masked Azides in Flow Microreactors2020

    • Author(s)
      Ichinari Daisuke、Ashikari Yosuke、Mandai Kyoko、Aizawa Yoko、Yoshida Jun‐ichi、Nagaki Aiichiro
    • Journal Title

      Angewandte Chemie International Edition

      Volume: 59 Issue: 4 Pages: 1567-1571

    • DOI

      10.1002/anie.201912419

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 18O-Labeled chiral compounds enable the facile determination of enantioselectivity by mass spectroscopy2020

    • Author(s)
      Mandai Kyoko、Tsuchihashi Yuta、Ashikari Yosuke、Yoshida Jun-ichi、Nagaki Aiichiro
    • Journal Title

      Tetrahedron Letters

      Volume: 61 Issue: 2 Pages: 151367-151367

    • DOI

      10.1016/j.tetlet.2019.151367

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Flow Technology for the Genesis and Use of (Highly) Reactive Organometallic Reagents2019

    • Author(s)
      Colella Marco、Nagaki Aichiiro、Luisi Renzo
    • Journal Title

      Chemistry A European Journal

      Volume: 26 Issue: 1 Pages: 19-32

    • DOI

      10.1002/chem.201903353

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Oxo‐Thiolation of Cationically Polymerizable Alkenes Using Flow Microreactors2019

    • Author(s)
      Ashikari Yosuke、Saito Kodai、Nokami Toshiki、Yoshida Jun‐ichi、Nagaki Aiichiro
    • Journal Title

      Chemistry A European Journal

      Volume: 25 Issue: 67 Pages: 15239-15243

    • DOI

      10.1002/chem.201903426

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Generation and Reaction of Functional Alkyllithiums by Using Microreactors and Their Application to Heterotelechelic Polymer Synthesis2019

    • Author(s)
      Nagaki Aiichiro、Yamashita Hiroki、Tsuchihashi Yuta、Hirose Katsuyuki、Takumi Masahiro、Yoshida Jun‐ichi
    • Journal Title

      Chemistry A European Journal

      Volume: 25 Issue: 60 Pages: 13719-13727

    • DOI

      10.1002/chem.201902867

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Recent topics of functionalized organolithiums using flow microreactor chemistry2019

    • Author(s)
      Nagaki Aiichiro
    • Journal Title

      Tetrahedron Letters

      Volume: 60 Issue: 32 Pages: 150923-150923

    • DOI

      10.1016/j.tetlet.2019.07.014

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Practical Continuous‐Flow Controlled/Living Anionic Polymerization2019

    • Author(s)
      Nakahara Yuichi、Furusawa Mai、Endo Yuta、Shimazaki Toshiya、Ohtsuka Keita、Takahashi Yusuke、Jiang Yiyuan、Nagaki Aiichiro
    • Journal Title

      Chemical Engineering & Technology

      Volume: 42 Issue: 10 Pages: 2154-2163

    • DOI

      10.1002/ceat.201900160

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Anionic Polymerization Using Flow Microreactors2019

    • Author(s)
      Takahashi Yusuke、Nagaki Aiichiro
    • Journal Title

      Molecules

      Volume: 24 Issue: 8 Pages: 1532-1532

    • DOI

      10.3390/molecules24081532

    • NAID

      120006624112

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Monolithiation of 5,5′‐Dibromo‐2,2′‐bithiophene Using Flow Microreactors: Mechanistic Implications and Synthetic Applications2019

    • Author(s)
      Nagaki Aiichiro、Jiang Yiyuan、Yamashita Hiroki、Takabayashi Naoshi、Takahashi Yusuke、Yoshida Jun-ichi
    • Journal Title

      Chemical Engineering & Technology

      Volume: 42 Issue: 10 Pages: 2113-2118

    • DOI

      10.1002/ceat.201900057

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Annulative Synthesis of Thiazoles and Oxazoles from Alkenyl Sulfoxides and Nitriles via Additive Pummerer Reaction2019

    • Author(s)
      Hori Mitsuki、Nogi Keisuke、Nagaki Aiichiro、Yorimitsu Hideki
    • Journal Title

      Asian Journal of Organic Chemistry

      Volume: 8 Issue: 7 Pages: 1084-1087

    • DOI

      10.1002/ajoc.201900169

    • NAID

      120006709414

    • Related Report
      2019 Annual Research Report 2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Blockage Detection and Diagnosis of Externally Parallelized Monolithic Microreactors2019

    • Author(s)
      Osamu Tonomura, Satoshi Taniguchi, Kazuki Nishi, Aiichiro Nagaki, Jun-ichi Yoshida, Katsuyuki Hirose, Norio Ishizuka and Shinji Hasebe
    • Journal Title

      Catalysts

      Volume: 9 Issue: 4 Pages: 308-319

    • DOI

      10.3390/catal9040308

    • Related Report
      2019 Annual Research Report 2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Suzuki-Miyaura Coupling Using Monolithic Pd Reactors and Scaling-Up by Series Connection of the Reactors2019

    • Author(s)
      Nagaki Aiichiro、Hirose Katsuyuki、Moriwaki Yuya、Takumi Masahiro、Takahashi Yusuke、Mitamura Koji、Matsukawa Kimihiro、Ishizuka Norio、Yoshida Jun-ichi
    • Journal Title

      Catalysts

      Volume: 9 Issue: 3 Pages: 300-300

    • DOI

      10.3390/catal9030300

    • Related Report
      2019 Annual Research Report 2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 1.Alkyllithiums Bearing Electrophilic Functional Groups: A Flash Chemistry Approach.2019

    • Author(s)
      Nagaki, A.; Yamashita, H.; Hirose, K.; Tsuchihashi, Y.; Yoshida, J.
    • Journal Title

      Angew. Chem. Int. Ed.

      Volume: 58 Issue: 12 Pages: 40274030-40274030

    • DOI

      10.1002/anie.201814088

    • Related Report
      2019 Annual Research Report 2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Synthesis of Functionalized Ketones from Acid Chlorides and Organolithiums by Extremely Fast Micromixing2019

    • Author(s)
      Nagaki Aiichiro、Sasatsuki Kengo、Ishiuchi Satoshi、Miuchi Nobuyuki、Takumi Masahiro、Yoshida Jun‐ichi
    • Journal Title

      Chemistry ? A European Journal

      Volume: 25 Issue: 19 Pages: 4946-4950

    • DOI

      10.1002/chem.201900743

    • Related Report
      2019 Annual Research Report 2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Modeling and Design of a Flow-Microreactor-Based Process for Synthesizing Ionic Liquids2019

    • Author(s)
      Nakahara Yuichi、Metten Bert、Tonomura Osamu、Nagaki Aiichiro、Hasebe Shinji、Yoshida Jun-ichi
    • Journal Title

      Organic Process Research & Development

      Volume: 23 Issue: 4 Pages: 641-647

    • DOI

      10.1021/acs.oprd.8b00436

    • Related Report
      2019 Annual Research Report 2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Molecular Weight Distribution of Polymers Produced by Anionic Polymerization Enables Mixability Evaluation2019

    • Author(s)
      Endo Yuta、Furusawa Mai、Shimazaki Toshiya、Takahashi Yusuke、Nakahara Yuichi、Nagaki Aiichiro
    • Journal Title

      Organic Process Research & Development

      Volume: 23 Issue: 4 Pages: 635-640

    • DOI

      10.1021/acs.oprd.8b00403

    • Related Report
      2019 Annual Research Report 2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] フローマイクロリアクターを用いた有機合成反応の選択性制御2019

    • Author(s)
      Takahashi, Y.; Nagaki, A.*
    • Journal Title

      化学プロセスの設計とスケールアップ、連続化技術、技術情報協会

    • Related Report
      2018 Annual Research Report
  • [Journal Article] フローマイクロリアクターを用いた高分子合成反応とその連続運転2019

    • Author(s)
      Nagaki, A.*; Nakahara, Y.; Endo, Y.
    • Journal Title

      化学プロセスの設計とスケールアップ、連続化技術、技術情報協会

    • Related Report
      2018 Annual Research Report
  • [Journal Article] フローマイクロリアクターを用いた有機合成反応の選択性制御2019

    • Author(s)
      Nagaki, A.*; Takumi, M.
    • Journal Title

      フローマイクロ合成の最新動向、ファインケミカル

    • Related Report
      2018 Annual Research Report
  • [Journal Article] マイクロリアクターの研究開発状況とその展望2019

    • Author(s)
      Takumi, M.; Nagaki, A.*
    • Journal Title

      化学装置、工業通信

    • Related Report
      2018 Annual Research Report
  • [Journal Article] Fast Micromixing Enables Selective Reactions with One of Several Same Functional Groups.2018

    • Author(s)
      Nagaki, A.; Yamashita, H.; Ishiuchi, S.; Takahashi, Y.; Imai, K.; Toshinari, K; Furusawa, M.; Yoshida, J.
    • Journal Title

      Chem. Lett

      Volume: 47 Issue: 1 Pages: 71-73

    • DOI

      10.1246/cl.170899

    • NAID

      130006302083

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Flash Generation and Borylation of 1-(trifluoromethyl)vinyllithium toward Synthesis of α-(trifluoromethyl)styrenes.2018

    • Author(s)
      Fujita, T.; Konno, N.; Watabe, Y.; Ichitsuka, T.; Nagaki, A.; Yoshida, J.; Ichikawa, J.
    • Journal Title

      J. Fluorine Chem.

      Volume: 207 Pages: 72-76

    • DOI

      10.1016/j.jfluchem.2018.01.004

    • NAID

      120007134197

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Transmission of Point Chirality to Axial Chirality for Strong Circular Dichroism in Triarylmethylium-o,o-dimers2018

    • Author(s)
      Suzuki Takanori、Ishigaki Yusuke、Iwai Tomohiro、Hayashi Yuki、Nagaki Aiichiro、Katoono Ryo、Fujiwara Kenshu、Yoshida Jun-ichi
    • Journal Title

      Synlett

      Volume: 29 Issue: 16 Pages: 2147-2154

    • DOI

      10.1055/s-0037-1610190

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Efficient Preparation of Cyclic α-Alkylidene β-Oxo Imides by Using a Flow Microreactor System2018

    • Author(s)
      Komuro, K.; Nagaki, A.; Shimoda, H.; Uwamori, M.; Yoshida, J.-i.; Nakada, M.
    • Journal Title

      Synlett

      Volume: 29 Issue: 15 Pages: 1989-1994

    • DOI

      10.1055/s-0037-1610228

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] フローマイクロリアクターの化学業界の動向2017

    • Author(s)
      Kim, H.; Nagaki, A.; Yoshida, J.
    • Journal Title

      「フローマイクロ合成の実用化への展望」シーエムシー出版

      Pages: 206-210

    • Related Report
      2017 Annual Research Report
  • [Journal Article] Generation of hazardous methyl azide and its application to synthesis of a key-intermediate of picarbutrazox, a new potent pesticide in flow2017

    • Author(s)
      Ichinari Daisuke、Nagaki Aiichiro、Yoshida Jun-ichi
    • Journal Title

      Bioorganic & Medicinal Chemistry

      Volume: 25 Issue: 23 Pages: 6224-6228

    • DOI

      10.1016/j.bmc.2017.07.005

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Micromixing Enables Chemoselective Reactions of Difunctional Electrophiles with Functional Aryllithiums.2017

    • Author(s)
      Nagaki, A.; Ishiuchi, S.; Imai, K.; Sasatsuki, K.; Nakahara, Y.; Yoshida, J.
    • Journal Title

      React. Chem. Eng.

      Volume: 2 Issue: 6 Pages: 862-870

    • DOI

      10.1039/c7re00142h

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] "Impossible" Chemistries Based on Flow and Micro.2017

    • Author(s)
      Yoshida, J.; Kim, H.; Nagaki, A.
    • Journal Title

      J. Flow Chem

      Volume: 7 Issue: 3-4 Pages: 60-64

    • DOI

      10.1556/1846.2017.00017

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Flow microreactor synthesis of 2,2-disubstituted oxetanes via 2-phenyloxetan-2-yl lithium2016

    • Author(s)
      Degennaro, L.; Nagaki, A.; Moriwaki, Y.; Romanazzi, G.; Dell’Anna, M. M.; Yoshida, J.; Luisi, R
    • Journal Title

      Flow microreactor synthesis of 2,2-disubs Open Chem.

      Volume: 14 Issue: 1 Pages: 377-382

    • DOI

      10.1515/chem-2016-0041

    • NAID

      120006305900

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] マイクロ流路を利用した空間的反応集積化2016

    • Author(s)
      Yoshida, J.*; Kim, H.; Nagaki, A.
    • Journal Title

      化学と工業

      Volume: 69 Pages: 117-119

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Flash cationic polymerization followed by bis-end-functionalization. A new approach to linear-dendritic hybrid polymers.2016

    • Author(s)
      Tani, Y.; Takumi, M.; Moronaga, S.; Nagaki, A.; Yoshida, J.-i.
    • Journal Title

      European Polymer Journal

      Volume: 79 Pages: 227-233

    • DOI

      10.1016/j.eurpolymj.2016.02.021

    • Related Report
      2016 Annual Research Report 2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Design of a Numbering-up System of Monolithic Microreactors and Its Application to Synthesis of a Key Intermediate of Valsaltan2016

    • Author(s)
      Aiichiro Nagaki, Katsuyuki Hirose, Osamu Tonomura, Satoshi Taniguchi, Toshiki Taga, Shinji Hasebe, Norio Ishizuka, and Jun-ichi Yoshida
    • Journal Title

      Org. Process Res. Dev.

      Volume: 20 Issue: 3 Pages: 687-691

    • DOI

      10.1021/acs.oprd.5b00414

    • Related Report
      2016 Annual Research Report 2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Generation and Reaction of Carbamoyl Anions in Flow: Applications in the Three-Component Synthesis of Functionalized -Ketoamides2016

    • Author(s)
      Aiichiro Nagaki, Yusuke Takahashi, and Jun-ichi Yoshida
    • Journal Title

      Angew. Chem., Int. Ed.

      Volume: 55 Issue: 17 Pages: 5327-5331

    • DOI

      10.1002/anie.201601386

    • Related Report
      2016 Annual Research Report 2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Integration of borylation of aryllithiums and Suzuki–Miyaura coupling using monolithic Pd catalyst2016

    • Author(s)
      Aiichiro Nagaki, Katsuyuki Hirose, Yuya Moriwaki, Koji Mitamura, Kimihiro Matsukawa, Norio Ishizuka, Jun-ichi Yoshida, J.
    • Journal Title

      Catal. Sci. Tech

      Volume: in press Issue: 13 Pages: 0-0

    • DOI

      10.1039/c5cy02098k

    • Related Report
      2016 Annual Research Report 2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Feasibility Study on Continuous Flow Controlled/Living Anionic Polymerization Processes2016

    • Author(s)
      Nagaki, A.*; Nakahara, Y.; Furusawa, M.; Sawaki, T.; Yamamoto, T.; Toukairin, H.; Tadokoro, S.; Shimazaki, T.; Ito, T.; Otake, M.; Arai, H.; Higashida, N.; Takahashi, Y.; Moriwaki, Y.; Tsuchihashi, Y.; Hirose, K.; Yoshida, J.*
    • Journal Title

      Org. Process Res. Dev.

      Volume: 20 Issue: 7 Pages: 1377-1382

    • DOI

      10.1021/acs.oprd.6b00158

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Switching Between Intermolecular and Intramolecular Reactions Using Flow Microreactors. Lithiation of 2-Bromo-2'-Silylbiphenyls2016

    • Author(s)
      Nagaki, A.*; Kim, S.; Miuchi, N.; Yamashita, H.; Hirose, K.; Yoshida, J.*
    • Journal Title

      Org. Chem. Front.

      Volume: 3 Issue: 10 Pages: 1250-1253

    • DOI

      10.1039/c6qo00257a

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Flow Microreactor Polymerization2016

    • Author(s)
      Nagaki, A.*
    • Journal Title

      Chemical Engineering

      Volume: 61 Pages: 51-60

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] マイクロ流路を利用した空間的反応集積化2016

    • Author(s)
      Jun-ichi Yoshida, Hejin Kim, Aiichiro Nagaki
    • Journal Title

      Chemistry & chemical industry

      Volume: 69 Pages: 117-119

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Polymerization of Vinyl Ethers Initiated by Dendritic Cations Using Flow Microreactors2015

    • Author(s)
      Aiichiro Nagaki, Masahiro Takumi, Yosuke Tani, and Jun-ichi Yoshida
    • Journal Title

      Tetrahedron

      Volume: 71 Issue: 35 Pages: 5973-5978

    • DOI

      10.1016/j.tet.2015.05.096

    • NAID

      120005674615

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Organolithiums Bearing Aldehyde Carbonyl Groups. A Flash Chemistry Approach2015

    • Author(s)
      Aiichiro Nagaki, Yuta Tsuchihashi, Suguru Haraki and Jun-ichi Yoshida
    • Journal Title

      Org. Biomol. Chem

      Volume: 13 Issue: 26 Pages: 7140-7145

    • DOI

      10.1039/c5ob00958h

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] 「Organolithium Chemistry Using Flow Microreactors and Its Applications to Palladium Catalyzed Crosscoupling」2020

    • Author(s)
      Aiichiro Nagaki
    • Organizer
      International conference and exhibition on Catalysis and Chemical science Madrid
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 「フロー合成による精密合成化学の革新」2020

    • Author(s)
      永木 愛一郎
    • Organizer
      京大テックフォーラム
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 「フローマイクロリアクターを用いた精密合成」2020

    • Author(s)
      永木 愛一郎
    • Organizer
      情報機構
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 「マイクロリアクターを用いた超高速反応による精密有機合成化学」2020

    • Author(s)
      永木 愛一郎
    • Organizer
      フロー精密合成コンソーシアム(FlowST)ワークショップ
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 「令和1年度のマイクロ化学研究の取り組みと今後の展望」2020

    • Author(s)
      永木 愛一郎
    • Organizer
      京都大学マイクロ化学生産研究コンソーシアム、2019 年度マイクロコンソーシアム講演会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 「マイクロリアクターを用いた超高速反応による精密有機合成化学」2020

    • Author(s)
      永木 愛一郎
    • Organizer
      住友化学特別講演会、住友化学(株)
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 「Organolithium Chemistry Using Flow Microreactors and Its Applications to Palladium Catalyzed Crosscoupling」2020

    • Author(s)
      Aiichiro Nagaki
    • Organizer
      5rd International Conference on Catalysis and Chemical Engineering (CCE-2020)
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 「"Impossible" Flask Chemistry Based on Flow Microreactor」2020

    • Author(s)
      Aiichiro Nagaki
    • Organizer
      Bari University
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 「マイクロリアクターを用いた超高速反応による精密有機合成化学」2019

    • Author(s)
      永木 愛一郎
    • Organizer
      奈良高専講演会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 「吉田潤一先生とともに築き上げたマイクロ高速合成化学分野とその後の展開について」2019

    • Author(s)
      永木 愛一郎
    • Organizer
      2019 年度京都大学マイクロコンソーシアム講演会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 「Reaction Selectivity Control by Extremely Fast Micromixing. Synthesis of Functionalized Ketones from Acid Chlorides and Organolithiums」2019

    • Author(s)
      Aiichiro Nagaki
    • Organizer
      3rd International Caparica Christmas Conference on Translational Chemistry (IC3TC2019)
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 「フローマイクロリアクターを用いた精密合成」2019

    • Author(s)
      永木 愛一郎
    • Organizer
      情報機構
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 「マイクロリアクターを用いた超高速合成化学」2019

    • Author(s)
      永木 愛一郎
    • Organizer
      環境&資源エネルギー研究会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 「マイクロリアクターを用いた超高速反応による精密有機合成化学」2019

    • Author(s)
      永木 愛一郎
    • Organizer
      有機合成化学協会有機合成夏期セミナー
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 「Anionic polymerization using flow microreactor systems and its applications to syntheses of structurally well-defined polymers」2019

    • Author(s)
      Aiichiro Nagaki
    • Organizer
      258th ACS National Meeting
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 「フローマイクロリアクターを用いた超高速反応による精密有機合成」2019

    • Author(s)
      永木 愛一郎
    • Organizer
      第51回構造有機化学若手の会夏の学校
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 「Organolithium Chemistry Using Flow Microreactors」2019

    • Author(s)
      Aiichiro Nagaki
    • Organizer
      The 5th Int'l Conference on Organic Chemistry (COC 2019)
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 「マイクロ合成化学」2019

    • Author(s)
      永木 愛一郎
    • Organizer
      東邦化学工業株式会社講演会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 「有機リチウム反応の高次制御によるクロスカップリング反応プロセスの高度化」2019

    • Author(s)
      永木 愛一郎
    • Organizer
      日本PDA製薬学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Organolithium Chemistry Using Flow Microreactors and Its Applications to Palladium Catalyzed Crosscoupling2019

    • Author(s)
      Aiichiro Nagaki
    • Organizer
      3rd International Conference on Catalysis and Chemical Engineering
    • Related Report
      2018 Annual Research Report
  • [Presentation] TBA2019

    • Author(s)
      永木 愛一郎
    • Organizer
      2018 年度マイクロコンソーシアム講演会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 超高速合成化学 ?マイクロリアクターの最前線2019

    • Author(s)
      永木 愛一郎
    • Organizer
      京大テックフォーラム
    • Related Report
      2018 Annual Research Report
  • [Presentation] マイクロリアクターを用いた超高速合成化学2019

    • Author(s)
      永木 愛一郎
    • Organizer
      第10回マイクロリアクターシステム研究所シンポジウム
    • Related Report
      2018 Annual Research Report
  • [Presentation] フローマイクロリアクターを用いた精密合成2019

    • Author(s)
      永木 愛一郎
    • Organizer
      情報機構
    • Related Report
      2018 Annual Research Report
  • [Presentation] Organolithium Chemistry Using Flow Microreactors2018

    • Author(s)
      Aiichiro Nagaki
    • Organizer
      International Pharma Conference and Expo,
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] フローマイクロリアクターを用いた超高速反応による精密合成2018

    • Author(s)
      永木 愛一郎
    • Organizer
      有機合成化学講習会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] フローマイクロリアクターを用いた精密合成2018

    • Author(s)
      永木 愛一郎
    • Organizer
      情報機構
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Organolithium Chemistry Using Flow Microreactors2018

    • Author(s)
      Aiichiro Nagaki
    • Organizer
      16th Annual Congress of International Drug Discovery Science and Technology
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Organolithium Chemistry Using Flow Microreactors2018

    • Author(s)
      Aiichiro Nagaki
    • Organizer
      The 4th Int'l Conference on Organic Chemistry (COC 2018)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Organolithium Chemistry Using Flow Microreactors and Its Applications to Palladium Catalyzed Crosscoupling2017

    • Author(s)
      aiichiro nagaki
    • Organizer
      International Conference on Catalysis and Chemical Engineering
    • Place of Presentation
      Baltimore, USA
    • Year and Date
      2017-02-14
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Pd触媒担持モノリシスリアクターを用いた鈴木-宮浦カップリング. 直列化および並列化によるスケールアップ2017

    • Author(s)
      永木 愛一郎
    • Organizer
      日本プロセス化学会2017サマーシンポジウム
    • Related Report
      2017 Annual Research Report
  • [Presentation] フローマイクロリアクターによる反応の選択性制御2017

    • Author(s)
      永木 愛一郎
    • Organizer
      化学工学会第49秋季大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Anionic Polymerizations Using Flow Microreactors2016

    • Author(s)
      aiichiro nagaki
    • Organizer
      Polymer Chemistry 2016 International Conference,
    • Place of Presentation
      Atlanta, USA
    • Year and Date
      2016-11-14
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Synthesis of Organofluorine Compounds Using Flow Microreactors2016

    • Author(s)
      aiichiro nagaki
    • Organizer
      2nd World Chemistry Conference,
    • Place of Presentation
      Toronto, Canada
    • Year and Date
      2016-08-08
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Organolithium Chemistry Using Flow Microreactors to Green Chemistry2016

    • Author(s)
      aiichiro nagaki
    • Organizer
      7th Annual Global Congress of Catalysis 2016
    • Place of Presentation
      Seoul, South Korea
    • Year and Date
      2016-06-30
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Remarkable Chemoselectivity by Flash Chemistry2016

    • Author(s)
      aiichiro nagaki
    • Organizer
      The 12th International Symposium on Organic Reactions
    • Place of Presentation
      Kyoto, Japan
    • Year and Date
      2016-04-22
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Organolithium Chemistry Using Flow Microreactors2016

    • Author(s)
      aiichiro nagaki
    • Organizer
      International Nanotechnology Conference & Expo
    • Place of Presentation
      Baltimore, USA
    • Year and Date
      2016-04-04
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] フローマイクロリアクターを用いたアニオン重合の連続運転2016

    • Author(s)
      永木愛一郎、中原祐一、古澤真維、沢木智也、山本哲也、東海林英明、田所真介、島崎寿也、伊藤 寿英、大竹正兼、荒井秀紀、東田直也、大塚啓太、高橋裕輔、森脇佑也、土橋祐太、廣瀬勝幸、吉田潤一
    • Organizer
      日本化学会第96春季年会
    • Place of Presentation
      京都
    • Year and Date
      2016-03-24
    • Related Report
      2015 Annual Research Report
  • [Presentation] フロー・マイクロ合成:均一系反応2016

    • Author(s)
      永木 愛一郎
    • Organizer
      第一回 新学術領域研究「反応集積化が導く中分子戦略:高次生物機能分子の創製」若手シンポジウム
    • Place of Presentation
      神戸
    • Year and Date
      2016-03-11
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] フッ素置換有機リチウム種の高次制御に基づく反応集積化2016

    • Author(s)
      永木 愛一郎
    • Organizer
      第一回 新学術領域研究「反応集積化が導く中分子戦略:高次生物機能分子の創製」若手シンポジウム
    • Place of Presentation
      神戸
    • Year and Date
      2016-03-11
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Organolithium Chemistry Using Flow Microreactors2016

    • Author(s)
      aiichiro nagaki
    • Organizer
      The 2nd Annual World Congress of Smart Materials-2016
    • Place of Presentation
      Havelock Road, Singapore
    • Year and Date
      2016-03-04
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] イオン反応の反応集積化2016

    • Author(s)
      永木 愛一郎
    • Organizer
      第一回 新学術領域研究「反応集積化が導く中分子戦略:高次生物機能分子の創製」平成27 年度第1 回成果報告会
    • Place of Presentation
      大阪
    • Year and Date
      2016-02-07
    • Related Report
      2015 Annual Research Report
  • [Presentation] Flash Chemistry Enables Chemoselective Reactions of Difunctional Electrophiles with Functionalized Aryllithiums2015

    • Author(s)
      Aiichiro Nagaki, Satoshi Ishiuchi, Keita Imai, and Jun-ichi Yoshida
    • Organizer
      The 2015 International Chemical Congress of Pacific Basin Societies
    • Place of Presentation
      Hawaii,USA
    • Year and Date
      2015-12-07
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Organolithium Chemistry Using Flow Microreactors2015

    • Author(s)
      aiichiro nagaki
    • Organizer
      4th Asia-Pacific Chemical and Biological Microfluidics Conferences
    • Place of Presentation
      Pharma, Vietnam
    • Year and Date
      2015-11-02
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Organolithium Chemistry Using Flow Microreactors to Green Chemistry2015

    • Author(s)
      aiichiro nagaki
    • Organizer
      2nd International Conference on Past and Present Research Systems of Green Chemistry
    • Place of Presentation
      Orlando, USA
    • Year and Date
      2015-09-14
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] フローマイクロリアクターを用いた精密カチオン重合2015

    • Author(s)
      永木愛一郎、宅見 正浩、谷 洋介、吉田潤一
    • Organizer
      化学工学会第47秋季大会
    • Place of Presentation
      北海道
    • Year and Date
      2015-09-09
    • Related Report
      2015 Annual Research Report
  • [Book] マイクロチャネル:マイクロ混合・反応 「マイクロ・ナノ熱工学の進展」2020

    • Author(s)
      Ashikari, Y.; Nagaki, A.*
    • Total Pages
      696
    • Publisher
      株式会社エヌ・ティー・エス
    • Related Report
      2019 Annual Research Report
  • [Book] マイクロリアクターの研究開発状況とその展望 「化学装置」2019

    • Author(s)
      Takumi, M.; Nagaki, A.*
    • Total Pages
      112
    • Publisher
      工業通信
    • Related Report
      2019 Annual Research Report
  • [Book] フローマイクロリアクターを用いた有機合成反応の選択性制御 「化学プロセスの設計とスケールアップ、連続化技術」2019

    • Author(s)
      Takahashi, Y.; Nagaki, A.*
    • Total Pages
      696
    • Publisher
      技術情報協会
    • Related Report
      2019 Annual Research Report
  • [Book] フローマイクロリアクターを用いた高分子合成反応とその連続運転「化学プロセスの設計とスケールアップ、連続化技術2019

    • Author(s)
      Nagaki, A.*; Nakahara, Y.; Endo, Y.
    • Total Pages
      696
    • Publisher
      技術情報協会
    • Related Report
      2019 Annual Research Report
  • [Book] フローマイクロリアクターを用いた有機合成反応の選択性制御「フローマイクロ合成の最新動向」2019

    • Author(s)
      Nagaki, A.*; Takumi, M.
    • Total Pages
      111
    • Publisher
      ファインケミカル
    • Related Report
      2019 Annual Research Report
  • [Book] フローマイクロ合成の実用化への展望2016

    • Author(s)
      Kim, H.; Nagaki, A.; Yoshida, J.
    • Total Pages
      211
    • Publisher
      シーエムシー出版
    • Related Report
      2016 Annual Research Report
  • [Book] Organometallic Flow Chemistry2016

    • Author(s)
      Nagaki, A.; Yoshida, J.
    • Total Pages
      38
    • Publisher
      Springer Nature
    • Related Report
      2016 Annual Research Report
  • [Book] Topics in Organometallic Chemistry2016

    • Author(s)
      Nagaki, A.; Yoshida, J.
    • Publisher
      Springer
    • Related Report
      2015 Annual Research Report
  • [Remarks] Publications 2019

    • URL

      http://www.sbchem.kyoto-u.ac.jp/orgsyn-lab/

    • Related Report
      2019 Annual Research Report
  • [Remarks] 京都大学 大学院工学研究科合成・生物化学専攻 有機合成化学研究室

    • URL

      http://www.sbchem.kyoto-u.ac.jp/yoshida-lab/index.php?yoshida-lab

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report

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Published: 2015-07-02   Modified: 2022-11-04  

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