| Budget Amount *help |
¥119,210,000 (Direct Cost: ¥91,700,000、Indirect Cost: ¥27,510,000)
Fiscal Year 2019: ¥23,140,000 (Direct Cost: ¥17,800,000、Indirect Cost: ¥5,340,000)
Fiscal Year 2018: ¥23,270,000 (Direct Cost: ¥17,900,000、Indirect Cost: ¥5,370,000)
Fiscal Year 2017: ¥23,270,000 (Direct Cost: ¥17,900,000、Indirect Cost: ¥5,370,000)
Fiscal Year 2016: ¥23,140,000 (Direct Cost: ¥17,800,000、Indirect Cost: ¥5,340,000)
Fiscal Year 2015: ¥26,390,000 (Direct Cost: ¥20,300,000、Indirect Cost: ¥6,090,000)
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| Outline of Final Research Achievements |
3D tissue morphogenesis in animals accompanies massive cell proliferation, cell migration and compartmentalization of a cell population. To understand these processes, we examined cellular and molecular mechanisms underlying 3D morphogenesis of somites using medaka and zebrafish as models, focusing dorsoventral patterning and elongation along the dorso-ventral axis. We identified a subgroup of dermomyotomal cells called horizontal boundary cells (HBCs) as crucial players for compartmentalization of dorsal and ventral cells. Embryological and genetic analyses demonstrated that HBCs play crucial roles in
the two major events of the process, i.e., refinement and maintenance. Furthermore, by tracking cell behavior of all cells in a somite, we elucidated a logic for somite tissue elongation, in which the regional difference in the speed of migrating cells in a somite facilitates cell rearrangement and promote elongation.
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