| Budget Amount *help |
¥71,110,000 (Direct Cost: ¥54,700,000、Indirect Cost: ¥16,410,000)
Fiscal Year 2019: ¥14,820,000 (Direct Cost: ¥11,400,000、Indirect Cost: ¥3,420,000)
Fiscal Year 2018: ¥14,820,000 (Direct Cost: ¥11,400,000、Indirect Cost: ¥3,420,000)
Fiscal Year 2017: ¥14,820,000 (Direct Cost: ¥11,400,000、Indirect Cost: ¥3,420,000)
Fiscal Year 2016: ¥13,000,000 (Direct Cost: ¥10,000,000、Indirect Cost: ¥3,000,000)
Fiscal Year 2015: ¥13,650,000 (Direct Cost: ¥10,500,000、Indirect Cost: ¥3,150,000)
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| Outline of Final Research Achievements |
In tissue morphogenesis, individual cells generate forces that exert on other cells. Tissue deformations are driven by those forces. In this study, to understand the dynamics of epithelial morphogenesis, we developed a mathematical model (3D vertex model) that captures cell mechanical behaviors and applied it to the analysis of the morphogenesis. We reveal that there is a mechanical role to proceed morphogenesis robustly in response to mechanical perturbations, a mechanism by which 3D formation of epithelial tissue arises from spatial pattern of gene expression at multicellular level, and a mechanism by which epithelial tissue folds spontaneously. Through these studies, we proposed the importance of understanding mechanics at the cellular level, and greatly developed mechanics on morphogenesis as an academic discipline.
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