| Budget Amount *help |
¥95,290,000 (Direct Cost: ¥73,300,000、Indirect Cost: ¥21,990,000)
Fiscal Year 2019: ¥18,460,000 (Direct Cost: ¥14,200,000、Indirect Cost: ¥4,260,000)
Fiscal Year 2018: ¥18,590,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥4,290,000)
Fiscal Year 2017: ¥18,590,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥4,290,000)
Fiscal Year 2016: ¥18,590,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥4,290,000)
Fiscal Year 2015: ¥21,060,000 (Direct Cost: ¥16,200,000、Indirect Cost: ¥4,860,000)
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| Outline of Final Research Achievements |
Adult external appendages of insects are generated from “folded” epithelial sheets called as imaginal discs. In this study, we found that down-regulation of type IV Collagen, a main component of the basal membrane on epithelial sheets, triggers deformation of the wing imaginal disc to the wing structure during development. Histochemical analyses revealed that downregulation of type IV Collagen alters the pattern of myosin II activation and Integrin after initiating the deformation of the wing disc. Our data suggest that remodeling of extracellular matrix could triggers autonomous deformation of the folded structure by regulating epithelial dynamics.
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