| Co-Investigator(Kenkyū-buntansha) |
松本 理器 神戸大学, 医学研究科, 教授 (00378754)
長峯 隆 札幌医科大学, 医学部, 教授 (10231490)
菊池 隆幸 京都大学, 医学研究科, 助教 (40625084)
小林 勝弘 岡山大学, 医歯薬学総合研究科, 教授 (60273984)
國枝 武治 愛媛大学, 医学系研究科, 教授 (60609931)
宇佐美 清英 京都大学, 医学研究科, 特定助教 (20829204)
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| Budget Amount *help |
¥111,150,000 (Direct Cost: ¥85,500,000、Indirect Cost: ¥25,650,000)
Fiscal Year 2019: ¥20,410,000 (Direct Cost: ¥15,700,000、Indirect Cost: ¥4,710,000)
Fiscal Year 2018: ¥20,410,000 (Direct Cost: ¥15,700,000、Indirect Cost: ¥4,710,000)
Fiscal Year 2017: ¥20,410,000 (Direct Cost: ¥15,700,000、Indirect Cost: ¥4,710,000)
Fiscal Year 2016: ¥20,410,000 (Direct Cost: ¥15,700,000、Indirect Cost: ¥4,710,000)
Fiscal Year 2015: ¥29,510,000 (Direct Cost: ¥22,700,000、Indirect Cost: ¥6,810,000)
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| Outline of Final Research Achievements |
We developed the concept of "Active DC shifts" as the Electrocorticogram(ECoG) biomarker of epileptic focus through the application of mathematical model on ECoG, multi-institutional analysis of surgical specimen, or animal model. We revealed the importance of neuron and glial cells in epileptic seizure generation. We clarified that the "red slow", the co-occurrence of slow wave and high frequency oscillation, was observed in the same areas where active DC shifts were recorded. On the other hand, we showed the versatility of these biomarker (active DC shifts and red slow) for the scalp-recorded electroencephalogram.
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