| Budget Amount *help |
¥149,890,000 (Direct Cost: ¥115,300,000、Indirect Cost: ¥34,590,000)
Fiscal Year 2019: ¥26,910,000 (Direct Cost: ¥20,700,000、Indirect Cost: ¥6,210,000)
Fiscal Year 2018: ¥26,910,000 (Direct Cost: ¥20,700,000、Indirect Cost: ¥6,210,000)
Fiscal Year 2017: ¥26,910,000 (Direct Cost: ¥20,700,000、Indirect Cost: ¥6,210,000)
Fiscal Year 2016: ¥26,910,000 (Direct Cost: ¥20,700,000、Indirect Cost: ¥6,210,000)
Fiscal Year 2015: ¥42,250,000 (Direct Cost: ¥32,500,000、Indirect Cost: ¥9,750,000)
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| Outline of Final Research Achievements |
To elucidate neural mechanisms underlying oscillatory phenomena in brain function, we have developed optogenetic tools and statistical methods. Specifically, opto-current-clamp induced oscillation reveals intrinsic frequency preferences in the neural circuits by oscillatory resonance. Furthermore, resonance or entrainment to intrinsic frequency is state-dependent. While monkeys perform bimanual motor sequence task, beta and high-gamma activities in the supplementary motor area (SMA) and pre-SMA showed reciprocal changes: Beta power was attenuated during early delay periods of updating trials but was increased during maintenance trials. Oscillatory phenomena in the nervous systems reveal how the neural circuits work in flexible and state dependent manner.I published two books, "learning brain" and "functions of the frontal cortex" as a part of achievement of this project
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