| Budget Amount *help |
¥107,380,000 (Direct Cost: ¥82,600,000、Indirect Cost: ¥24,780,000)
Fiscal Year 2019: ¥19,370,000 (Direct Cost: ¥14,900,000、Indirect Cost: ¥4,470,000)
Fiscal Year 2018: ¥19,500,000 (Direct Cost: ¥15,000,000、Indirect Cost: ¥4,500,000)
Fiscal Year 2017: ¥19,500,000 (Direct Cost: ¥15,000,000、Indirect Cost: ¥4,500,000)
Fiscal Year 2016: ¥19,500,000 (Direct Cost: ¥15,000,000、Indirect Cost: ¥4,500,000)
Fiscal Year 2015: ¥29,510,000 (Direct Cost: ¥22,700,000、Indirect Cost: ¥6,810,000)
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| Outline of Final Research Achievements |
The human brain areas have their own oscillatory activities which may have some physiological roles. One area must have several rhythms showing different physiological state. In this project, we have developed two new methods for human motor cortical (M1) studies. One is an analyzing method and the other is a modulation method.
Triad stimulation (analyzing method): We studied the intrinsic motor cortical rhythms in normal subjects and several neurological disorders. Normal rhythm was absent or the frequency was changed in patients with epilepsy, Parkinson disease, amyotrophic lateral sclerosis and others.
QPS (modulation method): This stimulation induces neuroplasticity or rhythmic modulation in the human M1, SMA, preSMA, sensory cortex and others. We showed functional difference between preSMA and SMA in visuo-motor learning tasks. This modulation may be applied to the treatment of some neurodegenerative disorders by influencing the intrinsic rhythms of cortical areas.
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