| Budget Amount *help |
¥152,230,000 (Direct Cost: ¥117,100,000、Indirect Cost: ¥35,130,000)
Fiscal Year 2019: ¥28,210,000 (Direct Cost: ¥21,700,000、Indirect Cost: ¥6,510,000)
Fiscal Year 2018: ¥30,160,000 (Direct Cost: ¥23,200,000、Indirect Cost: ¥6,960,000)
Fiscal Year 2017: ¥28,730,000 (Direct Cost: ¥22,100,000、Indirect Cost: ¥6,630,000)
Fiscal Year 2016: ¥33,410,000 (Direct Cost: ¥25,700,000、Indirect Cost: ¥7,710,000)
Fiscal Year 2015: ¥31,720,000 (Direct Cost: ¥24,400,000、Indirect Cost: ¥7,320,000)
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| Outline of Final Research Achievements |
Precise and global determination of each molecular species of lipid is a prerequisite for understanding their functions in physiology and disease, and for discovering novel bioactive lipids that may hold key to understand biology. In this study, we successfully established a non-targeted lipidomics platform that covers more than 8000 species of lipids. This system, when combined with targeted analysis, enabled us to capture lipid profiles more comprehensively, accurately and unbiasedly. This platform is powerful for visualizing lipid networks unbiasedly, and opened up a new avenue for discovering novel links between lipid metabolism and biological phenotypes. As for lipid imaging, we could successfully image fatty acid localization within single cells at a resolution of 200 nm.
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