| Budget Amount *help |
¥95,290,000 (Direct Cost: ¥73,300,000、Indirect Cost: ¥21,990,000)
Fiscal Year 2019: ¥18,460,000 (Direct Cost: ¥14,200,000、Indirect Cost: ¥4,260,000)
Fiscal Year 2018: ¥18,590,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥4,290,000)
Fiscal Year 2017: ¥18,590,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥4,290,000)
Fiscal Year 2016: ¥18,590,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥4,290,000)
Fiscal Year 2015: ¥21,060,000 (Direct Cost: ¥16,200,000、Indirect Cost: ¥4,860,000)
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| Outline of Final Research Achievements |
Membrane proteins play important roles in signal transduction in many biological events including brain, heart and endocrine system as well as organ development and growth. Such functions depend on intimate interplay between membrane proteins and lipid molecules. Previously, detailed molecular mechanisms how membrane proteins recognize fine biochemical nature of lipid molecules remained unclear. In this research, we studied molecular mechanisms underlying how membrane proteins, mainly ion channels and voltage sensing proteins, recognize detailed chemical nature (which we call lipoquality) of lipid molecules through combination of electrophysiology, mass spectrometry, structure biology, electron microscopic analysis and fluorometry. We found that voltage sensing phosphatase has key region sensing phospholipid in the membrane interface and that sperm has uneven distribution of phosphoinositides playing important role in sperm function.
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