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スーパーコンピューティングと革新的情報技術によるがんシステムの新次元探索

Planned

Project AreaConquering cancer through neo-dimensional systems understanding
Project/Area Number 15H05912
Research Category

Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

Allocation TypeSingle-year Grants
Review Section Complex systems
Research InstitutionThe University of Tokyo

Principal Investigator

宮野 悟  東京大学, 医科学研究所, 教授 (50128104)

Co-Investigator(Kenkyū-buntansha) 島村 徹平  名古屋大学, 医学系研究科, 特任准教授 (00623943)
白石 友一  国立研究開発法人国立がん研究センター, 研究所, ユニット長 (70516880)
PARK HEEWON  山口大学, 国際総合科学部, 助教 (70756642)
山口 類  愛知県がんセンター(研究所), システム解析学分野, 分野長 (90380675)
新井田 厚司  東京大学, 医科学研究所, 助教 (00772493)
片山 琴絵  東京大学, 医科学研究所, 助教 (40581195)
張 耀中  東京大学, 医科学研究所, 助教 (60817138)
井元 清哉  東京大学, 医科学研究所, 教授 (10345027) [Withdrawn]
玉田 嘉紀  東京大学, 情報理工学(系)研究科, 助教 (80435495)
Project Period (FY) 2015-06-29 – 2020-03-31
Project Status Granted (Fiscal Year 2019)
Budget Amount *help
¥180,310,000 (Direct Cost: ¥138,700,000、Indirect Cost: ¥41,610,000)
Fiscal Year 2019: ¥37,050,000 (Direct Cost: ¥28,500,000、Indirect Cost: ¥8,550,000)
Fiscal Year 2018: ¥37,180,000 (Direct Cost: ¥28,600,000、Indirect Cost: ¥8,580,000)
Fiscal Year 2017: ¥37,180,000 (Direct Cost: ¥28,600,000、Indirect Cost: ¥8,580,000)
Fiscal Year 2016: ¥37,180,000 (Direct Cost: ¥28,600,000、Indirect Cost: ¥8,580,000)
Fiscal Year 2015: ¥31,720,000 (Direct Cost: ¥24,400,000、Indirect Cost: ¥7,320,000)
Keywordsがん / システム生物学 / 統計的モデリング / バイオインフォマティクス / 人工知能
Outline of Annual Research Achievements

1.ヒトゲノム解析センタースパコン上に実装したゲノムデータ解析パイプラインGenomonに加え、「京」コンピュータ用にVirtual Grid Engineを開発し、さらに大規模なGenomon解析を実施できる体制を整備し、国内外での共同研究で多くの成果に貢献した。新規方法論としては、SAVs (splicing-associated variants)を検出する数理統計的手法を開発し、31のがん腫にわたる8,976サンプルのWES及びRNA シークエンスデータを用い、14,438のSAVsを検出した。検出されたSAVsの約50%が非GT-AG dinucleotidesを破壊するもので、ドナーサイトのイントロン部分の3番目及び5番目を含むものか新たなスプライス部位を作っているものであることが判明した。喫煙がSAVsと強く関連しており、一方で紫外線の影響は少ないことなどの知見が得られた。さらに、変異コールの新たな方法として、与えられた情報ソースに基づいたペアエンドリードに対する分割を導入し、複数の情報ソースを用いて既存の生成モデルを統合し新たなベイズ階層モデル法を構築方法OHVarfinDerを開発した。
2.大規模遺伝子ネットワークの解釈と知識発見のための情報方式の開発を富士通研究所と行い、Deep Tensorの技術を基に、「説明可能なAI」の開発に成功した。これにより、これまで開発してきたNetworkProfilerを始めとした大規模な遺伝子ネットワーク推定結果から、EMTや薬剤耐性に寄与しているメカニズムを一挙に浮かび上がらせる技術が実現する見込みである。研究の詳細は未発表である。これは、ネットワークバイオロジーの観点から他の生命科学研究へ大きな波及効果があると考えている。
3.Watson for Genomicsをゲノムの構造異常情報から評価を行い、現システムの限界を明らかにした。全ゲノムシークエンスが不可欠である症例も判明した。

Current Status of Research Progress
Current Status of Research Progress

1: Research has progressed more than it was originally planned.

Reason

ゲノムシークエンスのコストが大幅に下がり、同時に、スーパーコンピュータについても発展があり、これまでコスト的に困難であった研究が進展した。本新学術領域では、計算システム生物学とスーパーコンピュータをがん研究に融合することに加え、人工知能システム(IBM Watson for GenomicsやFujitsu Deep Tensorなど)を導入することで、がんのシステム異常の研究、さらには、生命科学研究をこれまでのスケールと次元を超えたところで実現することが特色としている。これまで、その導入により、新たな情報技術の構築と画期的な成果がでている。特に、計画研究・小川誠司教授とはシームレスな研究システムができており、がんの発生や進展過程について、国際共同研究も含め本年度もNatureやNature Microbiology誌をはじめ多くの重要な成果を発表した。人工知能システムWatson for Genomicsについては、研究現場の意見を反映させて方向を明らかにして改良が行われ、その有効性の範囲が明確になった。計画研究・高橋隆教授との共同研究では遺伝子発現データに基づいて推定されたネットワークからの知識発見のために、がん研究では初めてDeepTensorの応用のチャレンジが結実しつつある。ニューラルネットなどをベースとしたAIは、予測制度は高いものの、なぜそのような予測ができているかが隠れておりこれまでブラックボックスと言われていた。本研究では、富士通研究所との共同研究により、グラフ構造データを対象とした「説明可能なAI」の技術ができ、その有効性をがんバイオロジーの分野で検証している。これはWatson for Genomicsは対象とはしておらず、大きな飛躍があったと考えている。このようにシステム癌新次元の方式を探りながら、そしてシステム癌の方法論を昇華させながら多くの成果がえられるとともに、方法論に革新が起こっている。

Strategy for Future Research Activity

ゲノムの一次元地図から、時間軸・空間軸に広がるがんのシステム異常の複雑さの本態を捉え、システムがん研究が新たに直面している挑戦的課題に解決法を与え、がん研究を新次元へ転送するためのプラットフォームと方法論をまとめる。
1.がんゲノミクス研究に用いてきたWatson for Genomicsの有効性と限界が確認され、そこから得られた知見に基づき、ゲノムシークエンスデータだけでなく、RNAシークエンス、構造異常、エピゲノムへと発展させていく。また、全ゲノムシークエンス解析が、がんを理解するための第一歩であるというメッセージをアウトリーチ活動により示していく。
2.がんのシステム異常をネットワークの観点から捉える研究を推し進める。このために、遺伝子発現データからソフトウェアアップリケ―ションSiGNによって推定した大規模遺伝子ネットワークの解釈及び知識発見のための情報方式の開発を継続してすすめる。同時に、Watson for Genomicsに加えDeep Tensorのがん研究への様々な応用を合わせて進め、がんの全体象を把握した上で、その細部へと自在にシャトルする術を獲得する。これは、がん研究だけでなくネットワークバイオロジーの観点から他の生命科学研究へ大きな波及効果がある。
3.人工知能技術、とくにディープラーニングをシークエンスデータ解析へ活用する技術開発にチャレンジし、成果をだす。
4.小川教授らの研究(Nature 2019)により、食道がんにおいて、遺伝子変異が乳児期から獲得され、加齢とともに増加して70歳以上では全食道面積の40%~80%が、がん遺伝子の変異をもった細胞で置き換わっていること、がんがなぜ高齢者に生じ、飲酒や喫煙によって促進されるのかなど、がんが生ずる初期のメカニズムの解明と進展を理解するための突破口が創つくられた。こうした発見に基づき、今後ELSI研究との連携をさらに深める。

Report

(4 results)
  • 2018 Annual Research Report
  • 2017 Annual Research Report
  • 2016 Annual Research Report
  • 2015 Annual Research Report

Research Products

(171 results)

All 2019 2018 2017 2016 2015 Other

All Int'l Joint Research Journal Article Presentation Remarks

  • [Int'l Joint Research] University of Pavia/University of Verona(イタリア)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] University of Groningen/Radboud University Medical Center(オランダ)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] Necker Hospital/INSERM/Paris Cite University(フランス)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] Chulalongkorn University(タイ)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] Australian National University/James Cook University(オーストラリア)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research]

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] University of Chicago/Cleaveland Clinic(USA)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] Radboud University Medical Cente(The Netherlands)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] MLL Munich Leukemia Laboratory(Germany)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] University of Chicago/Cleveland Clinic/Case Western Reserve University(USA)

    • Related Report
      2016 Annual Research Report
  • [Int'l Joint Research] Chang Gung University(Taiwan)

    • Related Report
      2016 Annual Research Report
  • [Int'l Joint Research] The University of Chicago(USA)

    • Related Report
      2015 Annual Research Report
  • [Int'l Joint Research] Queen Mary University of London(UK)

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Robust sample-specific stability selection with effective reror control2019

    • Author(s)
      Park H, Yamada M, Imoto S, Miyano S
    • Journal Title

      J Comput Biol

      Volume: 26(3) Pages: 202-217

    • DOI

      10.1089/cmb.2018.0180

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A Bayesian model integration for mutation calling through data partitioning2019

    • Author(s)
      Moriyama T, Imoto S, Hayashi S, Shiraishi Y, Miyano S, Yamaguchi R
    • Journal Title

      Bioinformatics

      Volume: 印刷中

    • DOI

      10.1093/bioinformatics/btz233

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] GIMLET: Identifying biological modulators in context-specific gene regulation using local energy statistics2019

    • Author(s)
      Shimamura Teppei、Matsui Yusuke、Kajino Taisuke、Ito Satoshi、Takahashi Takashi、Miyano Satoru
    • Journal Title

      LNBI

      Volume: 10834 Pages: 124-137

    • DOI

      10.1007/978-3-030-14160-8_13

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Virtual Grid Engine: Accelerating thousands of omics sample analyses using large-scale supercomputers2019

    • Author(s)
      Ito S, Yadome M, Nishiki T, Ishiduki S, Inoue H, Yamaguchi R, Miyano S
    • Journal Title

      IEEE BIBM 2018

      Volume: 印刷中

    • DOI

      10.1109/bibm.2018.8621285

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Tumor subclonal progression model for cancer hallmark acquisition2019

    • Author(s)
      Matsui Yusuke、Miyano Satoru、Shimamura Teppei
    • Journal Title

      LNBI

      Volume: 10834 Pages: 115-123

    • DOI

      10.1007/978-3-030-14160-8_12

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Sensitivity analysis of agent-based simulation utilizing massively parallel computation and interactive data visualization2019

    • Author(s)
      Niida A, Hasegawa T, Miyano S
    • Journal Title

      PLoS One

      Volume: 14(3)

    • DOI

      10.1371/journal.pone.0210678

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Age-related remodelling of oesophageal epithelia by mutated cancer drivers2019

    • Author(s)
      Yokoyama A, Ogawa S., et al.
    • Journal Title

      Nature.

      Volume: 565 Pages: 312-317

    • DOI

      10.1038/s41586-018-0811-x

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Defective Epstein-Barr virus (EBV) in chronic active EBV infection and EBV-related hematological malignancy.2019

    • Author(s)
      Okuno Y, Murata T, Sato Y,Yoshida K, Sawada A, Inoue M, Kawa K, Seto M, Ohshima K, Shiraishi Y, Chiba K, Tanaka H, Miyano S, Nishida T, Kiyoi H, Kato S, Nakamura S, Morishima S, Yoshikawa T, Fujiwara S, Shimizu N, Isobe Y, Noguchi M, Kikuta A, Iwatsuki K, Takahashi Y, Kojima S, Ogawa S, Kimura H.
    • Journal Title

      Nature Microbiology

      Volume: 4 Pages: 404-413

    • DOI

      10.1038/s41564-018-0334-0

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Frequent structural variations involving programmed death ligands in Epstein-Barr virus-associated lymphomas.2019

    • Author(s)
      Kataoka Keisuke, Miyoshi Hiroaki, Sakata Seiji, Dobashi Akito, Couronne Lucile, Kogure Yasunori, Sato Yasuharu, Nishida Kenji, Gion Yuka, Shiraishi Yuichi, Tanaka Hiroko, et al
    • Journal Title

      Leukemia.

      Volume: Epub ahead of print

    • DOI

      10.1038/s41375-019-0380-5

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Frequent germline mutations of HAVCR2 in sporadic subcutaneous panniculitis-like T-cell lymphoma.2019

    • Author(s)
      Polprasert C, Takeuchi Y, Kakiuchi N, Yoshida K, Assanasen T, Sitthi W, Bunworasate U, Pirunsarn A, Wudhikarn K, Lawasut P, Uaprasert N, Kongkiatkamon S, Moonla C, Sanada M, Akita N, Takeda J, Fujii Y, Suzuki H, Nannya Y, Shiraishi Y, Chiba K, Tanaka H, Miyano S, Rojnuckarin P, Ogawa S, Makishima H
    • Journal Title

      Blood Adv

      Volume: 3 Pages: 588-595

    • DOI

      10.1182/bloodadvances.2018028340

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] A comprehensive characterization of cis-acting splicing-associated variants in human cancer2018

    • Author(s)
      Shiraishi Y, Kataoka K, Chiba K, Okada A, Kogure Y, Tanaka H, Ogawa S, Miyano S.
    • Journal Title

      Genome Research

      Volume: 28 Pages: 1111-1125

    • DOI

      10.1101/gr.231951.117

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Cancer evolution and heterogeneity.2018

    • Author(s)
      Mimori K, Saito T, Niida A, Miyano S
    • Journal Title

      Ann Gastroenterol Surg.

      Volume: 2(5) Pages: 332-338

    • DOI

      10.1002/ags3.12182

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] ALPHLARD: a Bayesian method for analyzing HLA genes from whole genome sequence data2018

    • Author(s)
      Hayashi S, Yamaguchi R, Mizuno S, Komura M, Miyano S, Nakagawa H, Imoto S
    • Journal Title

      BMC Genomics

      Volume: 19(1) Pages: 790-790

    • DOI

      10.1186/s12864-018-5169-9

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Understanding intratumor heterogeneity by combining genome analysis and mathematical modeling.2018

    • Author(s)
      Niida Atsushi、Nagayama Satoshi、Miyano Satoru、Mimori Koshi
    • Journal Title

      Cancer Sci.

      Volume: 109 Pages: 884-892

    • DOI

      10.1111/cas.13510

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A temporal shift of the evolutionary principle shaping intratumor heterogeneity in colorectal cancer.2018

    • Author(s)
      Saito T, Niida A, Uchi R, Hirata H, Kodama M, Okimoto T, Murakami K, Suzuki Y, Ogawa S, Miyano S, Mimori K, et al.
    • Journal Title

      Nat Commun

      Volume: 9 Pages: 1-10

    • DOI

      10.1038/s41467-018-05226-0

    • NAID

      120006551763

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Aberrant splicing and defective mRNA production induced by somatic spliceosome mutations in myelodysplasia2018

    • Author(s)
      Shiozawa Y, Malcovati L, Gall A, Sato-Otsubo A, Kataoka K, Sato Y, Watatani Y, Suzuki H, Yoshizato T, Yoshida K, Sanada M, Makishima H, Shiraishi Y, Chiba K, Hellstrom-Lindberg E, Miyano S, Ogawa S, Cazzola M
    • Journal Title

      Nat Commun.

      Volume: 9 Pages: 2642-2653

    • DOI

      10.1038/s41467-018-06063-x

    • NAID

      120006537149

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Hematopoietic lineage distribution and evolutionary dynamics of clonal hematopoiesis.2018

    • Author(s)
      Berger G,Ogawa S., et al.
    • Journal Title

      Leukemia.

      Volume: 131 Pages: 1846-1857

    • DOI

      10.1182/blood-2017-09-805879

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Gain-of-function IKBKB mutation causes human combined immune deficiency.2018

    • Author(s)
      Cardinez C, Miraghazadeh B, Tanita K, da Silva E, Hoshino A, Okada S, Chand R, Asano T, Tsumura M, Yoshida K, Ohnishi H, Kato Z, Yamazaki M, Okuno Y, Miyano S, Kojima S, Ogawa S, Andrews TD, Field MA, Burgio G,et al.
    • Journal Title

      J Exp Med.

      Volume: 215 Pages: 2715-2724

    • DOI

      10.1084/jem.20180639

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Cell-lineage level-targeted sequencing to identify acute myeloid leukemia with myelodysplasia-related changes2018

    • Author(s)
      Yokoyama K, Shimizu E, Yokoyama N, Nakamura S, Kasajima R, Ogawa M, Takei T,Ito M, Kobayashi A, Yamaguchi R, Imoto S, Miyano S, Tojo A
    • Journal Title

      Blood Adv

      Volume: 2(19) Pages: 2513-2521

    • DOI

      10.1182/bloodadvances.2017010744

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Circulating tumor DNA dynamically predicts response and/or relapse in patients with hematological malignancies2018

    • Author(s)
      Nakamura S, Yokoyama K, Yusa N, Ogawa M, Takei T, Kobayashi A, Ito M, Shimizu E, Kasajima R, Wada Y, Yamaguchi R, Imoto S, Nagamura-Inoue T, Miyano S, Tojo A
    • Journal Title

      International Journal of Hematology

      Volume: 108(4) Pages: 402-410

    • DOI

      10.1007/s12185-018-2487-2

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Azacitidine effectively reduces TP53-mutant leukemic cell burden in sccondary acute myeloid leukemia after cord blood transplantation2018

    • Author(s)
      Takei T, Yokoyama K, Nakamura S, Yusa N, Shimizu E, Kasajima R, Ogawa M, Tanoue S, Konuma T, Takahashi S, Kobayashi A, Yamazaki M, Yamaguchi R, Imoto S, Miyano S, Tojo A
    • Journal Title

      Leuk Lymphoma

      Volume: In press Pages: 1-2

    • DOI

      10.1080/10428194.2018.1443335

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Genomic characterization of biliary tract cancers identifies driver genes and predisposing mutations2018

    • Author(s)
      Wardell CP, Fujita M, Yamada T, Simbolo M, Fassan M, Karlic R, Polak P, Kim J, Hatanaka Y, Maejima K, Lawlor RT, Nakanishi Y, Mitsuhashi T et al
    • Journal Title

      J Hepatol.

      Volume: - Pages: 959-969

    • DOI

      10.1016/j.jhep.2018.01.009

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Different clonal dynamics of chronic myeloid leukaemia betwecn bone marrow and the central nervous system2018

    • Author(s)
      Ogawa M, Yokoyama K, Hirano M, Jimbo K, Ochi K, Kawamata T, Ohno N, Shimizu E, Yokoyama N, Yamaguchi R, Imoto S, Uchimaru K, Takahashi N, Miyano S, Imai Y, Tojo A
    • Journal Title

      Br J Haematol

      Volume: - Pages: 842-845

    • DOI

      10.1111/bjh.15065

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Targeting tyro3 ameliorates a model of PGRN-mutant FTLD-TDP via tau-mediated synaptic pathology.2018

    • Author(s)
      Fujita K, Chen X, Homma H, Tagawa K, Amano M, Saito A, Imoto S, Akatsu H, Hashizume Y, Kaibuchi K, Miyano S, Okazawa H.
    • Journal Title

      Nat Commun.

      Volume: 9 Issue: 1 Pages: 433-433

    • DOI

      10.1038/s41467-018-02821-z

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Adaptive NetworkProfiler for Identifying Cancer Characteristic-Specific Gene Regulatory Networks.2018

    • Author(s)
      Park H, Shimamura T, Imoto S, Miyano S
    • Journal Title

      Journal of Computational Biology

      Volume: 25(2) Pages: 130-145

    • DOI

      10.1089/cmb.2017.0120

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Prognostic relevance of genetic alterations in diffuse lower-grade gliomas.2018

    • Author(s)
      Aoki Kosuke、Nakamura Hideo、Suzuki Hiromichi et al.
    • Journal Title

      Neuro Oncol.

      Volume: 20 Pages: 66-67

    • DOI

      10.1093/neuonc/nox132

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Genomic Heterogeneity Within Individual Prostate Cancer Foci Impacts Predictive Biomarkers of Targeted Therapy2018

    • Author(s)
      VanderWeele DJ, Finney R, Katayama K, Gillard M, Paner G, Imoto S, Yamaguchi R, Wheeler D, Lack J, Cam M, Pontier A, Nguyen YTM, Maejima K, Sasaki-Oku A, Nakano K, Tanaka H, Vander Griend D, Kubo M, Ratain MJ, Miyano S, Nakagawa H
    • Journal Title

      Eur Urol Focus

      Volume: pii: S2405-4569(18) Pages: 30007-5

    • DOI

      10.1016/j.euf.2018.01.006

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Integrated molecular characterization of the lethal pediatric cancer pancreatoblastoma.2018

    • Author(s)
      Isobe T, Seki M, Yoshida K, Sekiguchi M, Shiozawa Y, Shiraishi Y,..., Kataoka K, Sato Y, Kawai T, Chiba K, Tanaka H, Shimamura T, Kato M, Iguchi A, Hama A, Taguchi T, Akiyama M, Fujimura J, Inoue A, Ito T, Deguchi T, Kiyotani C, Iehara T, Hosoi H, Oka A, Sanada M, Tanaka Y, Hata K, Miyano S, Ogawa S, Takita J
    • Journal Title

      Cancer Research

      Volume: 78(4) Pages: 865-876

    • DOI

      10.1158/0008-5472.can-17-2581

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Characterization of the B-cell receptor repertoires in peanut allergic subjects undergoing oral immunotherapy2018

    • Author(s)
      Kiyotani K, Mai TH, Yamaguchi R, Yew PY, Kulis M, Orgel K, Imoto S, Miyano S, Burks AW, Nakamura Y
    • Journal Title

      Journal of Human Genetics

      Volume: 63(2) Pages: 239-248

    • DOI

      10.1038/s10038-017-0364-0

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] A novel genetic and morphologic phenotype of ARID2-mediated myelodysplasia.2018

    • Author(s)
      Sakai H, Hosono N, Nakazawa H, Przychodzen B, Polprasert C, Carraway HE, Sekeres MA, Radivoyevitch T, Yoshida K, Sanada M, Yoshizato T, Kataoka K, Nakagawa MM, Ueno H, Nannya Y, Kon A, Shiozawa Y, Takeda J, Shiraishi Y, Chiba K, Miyano S, Singh J, Padgett RA, Ogawa S, Maciejewski JP, Makishima H
    • Journal Title

      Leukemia.

      Volume: 32(3) Pages: 839-843

    • DOI

      10.1038/leu.2017.319

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Prognostic relevance of integrated genetic profiling in adult T-cell leukemia/lymphoma2018

    • Author(s)
      Kataoka K, Iwanaga M, Yasunaga J, Watanabe T, Ogawa S and et al.
    • Journal Title

      Blood.

      Volume: 131 Pages: 215-225

    • DOI

      10.1182/blood-2017-01-761874

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Phenotype-Based Gene Analysis Allowed Successful Diagnosis of X-Linked Neutropenia Associated with a Novel Wasp Mutation. 2018 ; 97(2) : 367-69.2018

    • Author(s)
      Kobayashi M, Yokoyama K, Shimizu E, Yusa N, Ito M, Yamaguchi R, Imoto S, Miyano S, and Tojo A.
    • Journal Title

      Annals of Hematology

      Volume: 97 Issue: 2 Pages: 367-369

    • DOI

      10.1007/s00277-017-3134-3

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Clonal evolution in myelodysplastic syndromes2017

    • Author(s)
      da Silva-Coelho P, Kroeze LI, Yoshida K, Koorenhof-Scheele TN, Knops R, van de Locht LT, de Graaf AO, Massop M, Sandmann S, Dugas M, Stevens-Kroef MJ, Cermak J, Shiraishi Y, Chiba K, Tanaka H, Miyano S, de Witte T, Blijlevens NMA, Muus P, Huls G, van der Reijden BA, Ogawa S, Jansen JH.
    • Journal Title

      Nature communications

      Volume: 印刷中 Pages: 15099-15099

    • DOI

      10.1038/ncomms15099

    • NAID

      130005163316

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Recurrent SPI1 (PU.1) Fusions in High-risk Pediatric T Cell Acute Lymphoblastic Leukemia2017

    • Author(s)
      Seki M, Kimura S, Isobe T, Yoshida K, (13 authors), Masuda K, Kawamoto H, Ohki K, Kato M, Arakawa Y, Koh K, Hanada R, Moritake H, Akiyama M, Kobayashi R, Deguchi T, Hashii Y, Imamura T, Sato A, Kiyokawa N, Oka A, Hayashi Y, Takagi M, Manabe A, Ohara A, Horibe K, Sanada M, Iwama A, Mano H, Miyano S, Ogawa S, Takita J
    • Journal Title

      Nature genetis

      Volume: 49 Pages: 1274-1281

    • DOI

      10.1038/ng.3900

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] phyC: Clustering cancer evolutionary trees2017

    • Author(s)
      Matsui Y, Niida A, Uchi R, Mimori K, Miyano S, Shimamura T:
    • Journal Title

      PLoS Comput Biol

      Volume: 13(5) Pages: 1005509-1005509

    • DOI

      10.1371/journal.pcbi.1005509

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Large-scale DNA Barcode Library Generation for Biomolecule Identification in High-throughput Screens2017

    • Author(s)
      Lyons E, Sheridan P, Tremmel G, Miyano S, Sugano S
    • Journal Title

      Sci Rep

      Volume: 7(1) Pages: 13899-13899

    • DOI

      10.1038/s41598-017-12825-2

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Circulating exosomal microRNA-203 is associated with metastasis possibly via inducing tumor-associated macrophages in colorectal cancer.2017

    • Author(s)
      Takano Y, Masuda T, Iinuma H, Yamaguchi R, Sato K, Tobo T, Hirata H, Kuroda Y, Nambara S, Hayashi N, Iguchi T, Ito S, Eguchi H, Ochiya T, Yanaga K, Miyano S, Mimori K
    • Journal Title

      Oncotarget.

      Volume: 8(45) Pages: 78598-78613

    • DOI

      10.18632/oncotarget.20009

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Gene expression and risk of leukemic transformation in myelodysplasia2017

    • Author(s)
      Shiozawa Y, Malcovati L, Galli A, Pellagatti A, Karimi M, Sato-Otsubo A, Sato Y, Suzuki H, Yoshizato T, Yoshida K, Shiraishi Y, Chiba K, Makishima H, Boultwood J, Hellstroem-Lindberg E, Miyano S, Cazzola M, Ogawa S
    • Journal Title

      Blood

      Volume: 130(24) Pages: 2642-2653

    • DOI

      10.1182/blood-2017-05-783050

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Identification of a p53-repressed gene module in breast cancer cells2017

    • Author(s)
      Miyamoto T, Tanikawa C, Yodsurang V, Zhang YZ, Imoto S, Yamaguchi R, Miyano S, Nakagawa H, Matsuda K
    • Journal Title

      Oncotarget

      Volume: 8(34) Pages: 55821-55836

    • DOI

      10.18632/oncotarget.19608

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Identification of a p53 target, CD137L, that mediates growth suppression and immune response of osteosarcoma cells2017

    • Author(s)
      Yusuke Tsuda, Chizu Tanikawa, Takafumi Miyamoto, Makoto Hirata, Varalee Yodsurang, Yao-zhong Zhang, Seiya Imoto, Rui Yamaguchi, Satoru Miyano, Hiroshi Takayanagi, Hirotaka Kawano, Hidewaki Nakagawa, Sakae Tanaka, and Koichi Matsuda
    • Journal Title

      Scientific Reports

      Volume: 7(1) Pages: 10739-10739

    • DOI

      10.1038/s41598-017-11208-x

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Japanese genome-wide association study identifies a significant colorectal cancer susceptibility locus at chromosome 10p142017

    • Author(s)
      Takahashi Y, Sugimachi K, Yamamoto K, Niida A, Shimamura T, Sato T, Watanabe M, Tanaka J, Kudo S, Sugihara K, Hase K, Kusunoki M, Yamada K, Shimada Y, Moriya Y, Suzuki Y, Miyano S, Mori M, Mimori K
    • Journal Title

      Cancer Sci

      Volume: 108(11) Pages: 2239-2247

    • DOI

      10.1111/cas.13391

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] The Transcriptional Landscape of p53 Signalling Pathway2017

    • Author(s)
      Tanikawa C, Zhang YZ, Yamamoto R, Tsuda Y, Tanaka M, Funauchi Y, Mori J, Imoto S, Yamaguchi R, Nakamura Y, Miyano S, Nakagawa H, Matsuda K
    • Journal Title

      EBioMedicine

      Volume: 20 Pages: 109-119

    • DOI

      10.1016/j.ebiom.2017.05.017

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Abnormal hematopoiesis and autoimmunity in human subjects with germline IKZF1 mutations2017

    • Author(s)
      Hoshino A, Okada S, Yoshida K, Nishida N, Okuno Y, Ueno H, Yamashita M, Okano T, Tsumura M, Nishimura S, Sakata S, Kobayashi M, Nakamura H, Kamizono J, Mitsui-Sekinaka K, Ichimura T, Ohga S, Nakazawa Y, Takagi M, Imai K, Shiraishi Y, Chiba K, Tanaka H, Miyano S, Ogawa S, Kojima S, Nonoyama S, Morio T, Kanegane H.
    • Journal Title

      Journal of Allergy and Clinical Immunology

      Volume: - Pages: 223-231

    • DOI

      10.1016/j.jaci.2016.09.029

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Genome-wide screening of DNA methylation associated with lymph node metastasis in esophageal squamous cell carcinoma2017

    • Author(s)
      Nagata Hiroaki、Kozaki Ken-Ichi、Muramatsu Tomoki、Hiramoto Hidekazu、Tanimoto Kousuke、Fujiwara Naoto、Imoto Seiya、Ichikawa Daisuke、Otsuji Eigo、Miyano Satoru、Kawano Tatsuyuki、Inazawa Johji
    • Journal Title

      Oncotarget

      Volume: 8 Pages: 37740-37750

    • DOI

      10.18632/oncotarget.17147

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Haploinsufficiency of TNFAIP3 (A20) by germline mutation is involved in autoimmune lymphoproliferative syndrome2017

    • Author(s)
      Takagi M, Ogata S, Ueno H, Yoshida K, Yeh T, Hoshino A, Piao J, Yamashita M, Nanya M, Okano T, Kajiwara M, Kanegane H, Muramatsu H, Okuno Y, Shiraishi Y, Chiba K, Tanaka H, Bando Y, Kato M, Hayashi Y, Miyano S, Imai K, Ogawa S, Kojima S, Morio T.
    • Journal Title

      J Allergy Clin Immuno

      Volume: - Pages: 1914-1922

    • DOI

      10.1016/j.jaci.2016.09.038

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Hypoxic adaptation of leukemic cells infiltrating the CNS affords a therapeutic strategy targeting VEGFA.2017

    • Author(s)
      Kato Itaru、Nishinaka Yoko、Nakamura Masahiro、et al.
    • Journal Title

      Blood

      Volume: 129 Pages: 3126-3129

    • DOI

      10.1182/blood-2016-06-721712

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Clinical significance of T cell clonality and expression levels of immune-related genes in endometrial cancer2017

    • Author(s)
      Ikeda Y, Kiyotani K, Yew PY, Sato S, Imai Y, Yamaguchi R, Miyano S, Fujiwara K, Hasegawa K, Nakamura Y
    • Journal Title

      Oncology Reports

      Volume: 37(5) Pages: 2603-2610

    • DOI

      10.3892/or.2017.5536

    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Genetic abnormalities in myelodysplasia and secondary acute myeloid leukemia: impact on outcome of stem cell transplantation2017

    • Author(s)
      Yoshizato T et al., Makishima H, Ogawa S.
    • Journal Title

      Blood

      Volume: 印刷中 Pages: 2347-2358

    • DOI

      10.1182/blood-2016-12-754796

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Whole genome sequencing discriminate hepatocellular carcinoma with intrahepatic metastasis from multicentric tumors.2017

    • Author(s)
      Furuta M, Ueno M, Fujimoto A, Hayami S, Yasukawa S, Kojima F, Arihiro K, Kawakami Y, Wardell CP, Shiraishi Y, Tanaka H, Nakano K, Maejima K, Sasaki-Oku A, Tokunaga N, Boroevich KA, Abe T, Aikata H, Ohdan H, Gotoh K, Kubo M, Tsunoda T, Miyano S, Chayama K, Yamaue H, Nakagawa H
    • Journal Title

      J Hepatic.

      Volume: 66(2) Pages: 363-373

    • DOI

      10.1016/j.jhep.2016.09.021

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Dynamics of clonal evolution in myelodysplastic syndromes2017

    • Author(s)
      Makishima H, et al.
    • Journal Title

      Nature genetics

      Volume: 49 Pages: 204-204

    • DOI

      10.1038/ng.3742

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] OVarCall: Bayesian Mutation Calling Method Utilizing Overlapping Paired-End Reads2017

    • Author(s)
      Moriyama T, Shiraishi Y, Chiba K, Yamaguchi R, Imoto S, Miyano S
    • Journal Title

      IEEE Transactions on NanoBioscience

      Volume: 14 Pages: 116-122

    • DOI

      10.1109/tnb.2017.2670601

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A novel adaptive penalized logistic regression for uncovering biomarker associated with anti-cancer drug sensitivity2017

    • Author(s)
      Park H, Shiraishi Y, Imoto S, Miyano S
    • Journal Title

      EEE/ACM Trans Comput Biol Bioinform

      Volume: -

    • DOI

      10.1109/tcbb.2016.2561937

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Interaction-based feature selection for uncovering cancer driver genes through copy number-driven expression level2017

    • Author(s)
      Park H, Niida A, Imoto S, Miyano S
    • Journal Title

      J Comput Biol

      Volume: 24(2) Pages: 138-152

    • DOI

      10.1089/cmb.2016.0140

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Addiction to the IGF2-ID1-IGF2 circuit for maintenance of the breast cancer stem-like cells.2017

    • Author(s)
      Tominaga K, Shimamura T, Kimura N, Murayama T, Matsubara D, Kanauchi H, Niida A, Shimizu S, Nishioka K, Tsuji EI, Yano M, Sugano S, Shimono Y, Ishii H, Saya H, Mori M, Akashi K, Tada KI, Ogawa T, Tojo A, Miyano S, Gotoh N
    • Journal Title

      Oncogene.

      Volume: 36(9) Pages: 1276-1286

    • DOI

      10.1038/onc.2016.293

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Sequence-specific bias correction for RNA-seq data using recurrent neural networks2017

    • Author(s)
      Zhang Y-Z, Yamaguchi R, Imoto S, Miyano S
    • Journal Title

      BMC Genomics

      Volume: 18(Suppl 1) Pages: 1044-1044

    • DOI

      10.1186/s12864-016-3262-5

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Characterization of T-cell Receptor Repertoire in Inflamed Tissues of Patients with Crohn's Disease Through Deep Sequencing2016

    • Author(s)
      Chapman CG, Yamaguchi R, Tamura K, Weidner J, Imoto S, Kwon J, Fang H, Yew PY, Marino SR, Miyano S, Nakamura Y, Kiyotani K
    • Journal Title

      Inflamm Bowel Dis.

      Volume: 22(6) Pages: 1275-1285

    • DOI

      10.1097/mib.0000000000000752

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Whole-genome mutational landscape and characterization of noncoding and structural mutations in liver cancer2016

    • Author(s)
      Fujimoto A et al.
    • Journal Title

      Nat Genet.

      Volume: 48 Pages: 500-509

    • DOI

      10.1038/ng.3547

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Aberrant PD-L1 expression via 3'-UTR disruption in multiple cancers.2016

    • Author(s)
      Kataoka K, et al.
    • Journal Title

      Nature

      Volume: 534 Issue: 7607 Pages: 402-406

    • DOI

      10.1038/nature18294

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Identification of RNA-binding protein LARP4B as a tumor suppressor in glioma2016

    • Author(s)
      Koso H, Yi H, Sheridan P, Miyano S, Ino Y, Todo T, Watanabe S.
    • Journal Title

      Cancer Res

      Volume: 76 Pages: 2254-2264

    • DOI

      10.1158/0008-5472.can-15-2308

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Characterization of the T cell repertoire by deep T cell receptor sequencing in tissues and blood from patients with advanced colorectal cancer2016

    • Author(s)
      Muramatsu T, Kozaki KI, Imoto S, Yamaguchi R, Tsuda H, Kawano T, Fujiwara N, Morishita M, Miyano S, Inazawa J.
    • Journal Title

      Oncol Lett

      Volume: - Pages: 3643-3649

    • DOI

      10.1038/onc.2016.71

    • Related Report
      2016 Annual Research Report 2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] 8q24 Polymorphisms and Diabetes Mellitus Regulate Apolipoprotein A-IV in Colorectal Carcinogenesis.2016

    • Author(s)
      Sugimachi K, Yamaguchi R, Eguchi H, Ueda M, Niida A, Sakimura S, Hirata H, Uchi R, Shinden Y, Iguchi T, Morita K, Yamamoto K, Miyano S, Mori M, Maehara Y, Mimori K
    • Journal Title

      Ann Surg Oncol.

      Volume: 23(Suppl 4) Pages: 546-551

    • DOI

      10.1245/s10434-016-5374-1

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Somatic mutations in plasma cell-free DNA are diagnostic markers for esophageal squamous cell carcinoma recurrence.2016

    • Author(s)
      Ueda M, Iguchi T, Masuda T, Nakahara Y, Hirata H, Uchi R, Niida A, Momose K, Sakimura S, Chiba K, Eguchi H, Ito S, Sugimachi K, Yamasaki M, Suzuki Y, Miyano S, Doki Y, Mori M, Mimori K
    • Journal Title

      Oncotarget.

      Volume: 7(38) Pages: 62280-62291

    • DOI

      10.18632/oncotarget.11409

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Reduced expression of APC-1B but not APC-1A by the deletion of promoter 1B is responsible for familial adenomatous polyposis2016

    • Author(s)
      Yamaguchi K, Nagayama S, Shimizu E, Komura M, Yamaguchi R, Shibuya T, Arai M, Hatakeyama S, Ikenoue T, Ueno M, Miyano S, Imoto S, Furukawa Y
    • Journal Title

      Scientific Report

      Volume: 6 Pages: 26011-26011

    • DOI

      10.1038/srep26011

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A likelihood-free filtering method via approximate Bayesian computation in evaluating biological simulation models2016

    • Author(s)
      Hasegawa T, Niida A, Mori T, Shimamura T, Yamaguchi R, Miyano S, Akutsu T, Imoto S
    • Journal Title

      Computational Statistics and Data Analysis

      Volume: 94 Pages: 63-74

    • DOI

      10.1016/j.csda.2015.08.003

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Gene set differential analysis of time course expression profiles via sparse estimation in functional logistic model2016

    • Author(s)
      Kayano M, Matsui H, Yamaguchi R, Imoto S, Miyano S
    • Journal Title

      Biostat

      Volume: 17 Pages: 235-248

    • DOI

      10.1093/biostatistics/kxv037

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Integrated molecular profiling of human gastric cancer identifies DDR2 as a potential regulator of peritoneal dissemination2016

    • Author(s)
      Kurashige J, Hasegawa T, Niida A, Sugimachi K, Deng N, Mima K, Uchi R, Sawada G, Takahashi Y, Eguchi H, Inomata M, Kitano S, Fukagawa T, Sasako M, Sasaki H, Sasaki S, Mori M, Yanagihara K, Baba H, Miyano S, Tan P, Mimori K.
    • Journal Title

      Sci Rep

      Volume: 6 Pages: 22371-22371

    • DOI

      10.1038/srep22371

    • NAID

      120006352400

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] D3M: detection of differential distributions of methylation levels2016

    • Author(s)
      Matsui Y, Mizuta M, Miyano S, Shimamura T
    • Journal Title

      Bioinformatics

      Volume: 印刷中 Pages: 2248-2255

    • DOI

      10.1093/bioinformatics/btw138

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Genomic landscape of esophageal squamous cell carcinoma a Japanese population2016

    • Author(s)
      Sawada G, Niida A, Uchi R, Hirata H, Shimamura T, (38 authors), Mimori K
    • Journal Title

      Gastroenterology.

      Volume: 150(5) Pages: 1049-1051

    • DOI

      10.1053/j.gastro.2016.01.035

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] A simple model-based approach to inferring and visualizing cancer mutation signatures2016

    • Author(s)
      Yuichi Shiraishi , Georg Tremmel, Satoru Miyano, Matthew Stephens
    • Journal Title

      PLoS Genetics

      Volume: 11(12)

    • DOI

      10.1371/journal.pgen.1005657

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Integrated multiregional analysis proposing a new model of colorectal cancer evolution2016

    • Author(s)
      R. Uchi (他40名, 山本36番目)
    • Journal Title

      PLoS Genet

      Volume: 12 Pages: 1005778-1005778

    • DOI

      10.1371/journal.pgen.1005778

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Oncogenic roles of TOPK and MELK, and effective growth suppression by small molecular inhibitors in kidney cancer cells2016

    • Author(s)
      T. Kato, H. Inoue, S. Imoto, Y. Tamada, T. Miyamoto, Y. Matsuo, Y. Nakamura and J.H. Park
    • Journal Title

      Oncotarget

      Volume: 7 Pages: 17652-17664

    • DOI

      10.18632/oncotarget.7755

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Variegated RHOA mutations in adult T-cell leukemia/lymphoma.2016

    • Author(s)
      Nagata Y, Kontani K, Enami T, Kataoka K, Ishii R, Totoki Y, Kataoka TR, Hirata M, Aoki K, Nakano K, Kitanaka A, Sakata-Yanagimoto M, Egami S, Shiraishi Y, Chiba K, Tanaka H, Shiozawa Y, Yoshizato T, (9名), Miyano S, Nureki O, Shibata T, Haga H, Shimoda K, Katada T, Chiba S, Watanabe T, Ogawa S
    • Journal Title

      Blood.

      Volume: 127 Pages: 596-604

    • DOI

      10.1182/blood-2015-06-644948

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] High performance computing of a fusion gene detection pipeline on the K computer2015

    • Author(s)
      Ito S, Shiraishi Y, Shimamura T, Chiba K, Miyano S
    • Journal Title

      BIBM

      Volume: 2015 Pages: 1441-1447

    • DOI

      10.1109/bibm.2015.7359888

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Elevated beta-catenin pathway as a novel target for patients with resistance to EGF receptor targeting drugs.2015

    • Author(s)
      Nakata A, Yoshida R, Yamaguchi R, Yamauchi M, Tamada Y, Fujita A, Shimamura T, Imoto S, Higuchi T, Nomura M, Kimura T, Nokihara H, Higashiyama M, Kondoh K, Nishihara H, Tojo A, Yano S, Miyano S, Gotoh N
    • Journal Title

      Scientific Reports

      Volume: 5 Pages: 13076-13076

    • DOI

      10.1038/srep13076

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Recursive Random Lasso (RRLasso) for Identifying Anti-Cancer Drug Targets2015

    • Author(s)
      Park H, Imoto S, Miyano S
    • Journal Title

      PLOS ONE

      Volume: 10 Pages: 147-152

    • DOI

      10.1371/journal.pone.0141869

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] An Integrative Analysis to Identify Driver Genes in Esophageal Squamous Cell Carcinoma.2015

    • Author(s)
      Sawada G, Niida A, Hirata H, Komatsu H, Uchi R, Shimamura T, Takahashi Y, Kurashige J, Matsumura T, Ueo H, Takano Y, Ueda M, Sakimura S, Shinden Y, Eguchi H, Sudo T, Sugimachi K, Yamasaki M, Tanaka F, Tachimori Y, Kajiyama Y, Natsugoe S, Fujita H, Tanaka Y, Calin G, Miyano S, Doki Y, Mori M, Mimori K
    • Journal Title

      PLoS One.

      Volume: 10(10)

    • DOI

      10.1371/journal.pone.0139808

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Quantitative characterization of T-cell repertoire in allogeneic hematopoietic stem cell transplant recipients2015

    • Author(s)
      Yew PY, Alachkar H, Yamaguchi R, Kiyotani K, Fang H, Yap KL, Liu HT, Wickrema A, Artz A, van Besien K, Imoto S, Miyano S, Bishop MR, Stock W, Nakamura Y
    • Journal Title

      Bone Marrow Transplantation

      Volume: 50 Pages: 1227-1234

    • DOI

      10.1038/bmt.2015.133

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Integrated molecular analysis of adult T-cell leukemia/lymphoma.2015

    • Author(s)
      Kataoka K, Nagata Y, Kitanaka A, Shiraishi Y, Shimamura T, Yasunaga J, Totoki Y, Chiba K, Sato-Otsubo A, Nagae G, et al.
    • Journal Title

      Nat Genet

      Volume: 47(11) Pages: 1304-1315

    • DOI

      10.1038/ng.3415

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Binary Contingency Table Method for Analyzing Gene Mutation in Cancer Genome2015

    • Author(s)
      Ayada E, Niida A, Hasegawa T, Miyano S, Imoto S
    • Journal Title

      Lecture Notes in Computer Science

      Volume: 9096 Pages: 12-23

    • DOI

      10.1007/978-3-319-19048-8_2

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Presentation] ゲノム医療におけるAI技術活用の課題2019

    • Author(s)
      宮野 悟
    • Organizer
      第154回日本医学会シンポジウム
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] がんビッグデータ 解析の現状と未来2019

    • Author(s)
      宮野 悟
    • Organizer
      第1回日本メディカルAI学会学術集会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] システム生物学による薬物標的遺伝子の探索2019

    • Author(s)
      宮野 悟
    • Organizer
      京都大学大学院医学研究科創薬医学講座
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 未来のがんゲノム研究を支えるコンピュータ資源と人工知能2019

    • Author(s)
      宮野 悟
    • Organizer
      West Japan Hematology Forum In Osaka
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 世界のトップのがんゲノム研究が生まれるスーパーコンピュータとその運用2019

    • Author(s)
      宮野 悟
    • Organizer
      第11回トップセミナー
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Challenges to Cancer Big Data by Artificial Intelligence and Supercomputers2019

    • Author(s)
      Satoru Miyano
    • Organizer
      The 8th Global Reverse Phase Protein Array Workshop
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 人工知能によるがんの臨床シークエンス支援研究の現場から2018

    • Author(s)
      宮野 悟
    • Organizer
      福島県立医大臨床腫瘍セミナー
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 人工知能とスパコンでがんのシステム異常を暴き出し患者さんへ2018

    • Author(s)
      宮野 悟
    • Organizer
      第2回Co-stimulators’Assembly
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] ゲノム解析の最前線と次世代のゲノム診療2018

    • Author(s)
      宮野 悟
    • Organizer
      第28回がん臨床研究フォーラム
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Watsonを用いたがんゲノム医療支援最前線2018

    • Author(s)
      宮野 悟
    • Organizer
      オミックス医療学会大会 ~AI創薬フォーラム~
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 人工知能のパワースーツを着たオンコロジストの登場2018

    • Author(s)
      宮野 悟
    • Organizer
      第25回外科フォーラム
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 『AIとスパコンによる最先端のがん治療』~がん患者は待てない~2018

    • Author(s)
      宮野 悟
    • Organizer
      みどり会講演会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 人工知能と医療・研究の現在・将来2018

    • Author(s)
      宮野 悟
    • Organizer
      「21世紀を考える会」第30回天城合宿研究会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] AI がもたらすこれからの生命科学2018

    • Author(s)
      宮野 悟
    • Organizer
      第58回 生命科学 夏の学校
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 人工知能とスパコンで拓くがん臨床シークエンス2018

    • Author(s)
      宮野 悟
    • Organizer
      第28回 DM club meeting
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 統合計算生命科学のもたらす ゲノム医療の展望2018

    • Author(s)
      宮野 悟
    • Organizer
      第15回DIA日本年会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Revolutionizing Cancer Genomic Medicine by AI2018

    • Author(s)
      宮野 悟
    • Organizer
      東大工学系電気系工学専攻融合情報学特別講義Ⅳ
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Arrival of Oncologists Armed with AI-Powered Exoskeletons2018

    • Author(s)
      Satoru Miyano
    • Organizer
      ICBET2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Accelerating Cancer Clinical Sequence by Artificial Intelligence and Supercomputer2018

    • Author(s)
      Satoru Miyano
    • Organizer
      Seminar Precision Medicine in the 21st Century in Mexico
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Accelerating Cancer Genomics by Supercomputer and AI2018

    • Author(s)
      Satoru Miyano
    • Organizer
      AI and Precision Forum
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Revolutionizing Cancer Clinical Sequencing by IBM Watson and Supercomputer with Big Data2018

    • Author(s)
      Satoru Miyano
    • Organizer
      The 1st Baodi Forum on Medical Innovations in Health and Disease
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Cancer Genomics and Clinical Sequencing2018

    • Author(s)
      Satoru Miyano
    • Organizer
      Genesort Conference in Precision Medicine in Cancer Genomics
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Unraveling Cancer Systems Disorders from Big Data by Supercomputers2018

    • Author(s)
      Satoru Miyano
    • Organizer
      2018 8th International Conference on Bioscience, Biochemistry and Bioinformatics
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] AIによるがんの臨床シークエンス支援研究の現場から2018

    • Author(s)
      宮野 悟
    • Organizer
      第41回日本眼科手術学会学術総会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 人工知能とスパコンで実現するがんの全遺伝子臨床シークエンス2018

    • Author(s)
      宮野 悟
    • Organizer
      平成29年度広島大学医学部小児科学教室同門会総会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Cancer Big Data Analysis with Supercomputers2018

    • Author(s)
      Satoru Miyano
    • Organizer
      シカゴ大学合同フォーラム
    • Related Report
      2017 Annual Research Report
  • [Presentation] Watsonとスパコンで実現したがんOne-Week全ゲノム臨床シークエンス2018

    • Author(s)
      宮野 悟
    • Organizer
      第26回バイオフィジオロジー研究会シンポジウム
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Why AI is indispensable for biomedical research? -From a viewpoint of cancer genomic medicine2017

    • Author(s)
      Satoru Miyano
    • Organizer
      The Inaugural Academia Sinica Data Science Frontiers Workshop in Taipei
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 先端ゲノミクスによる癌の分子基盤の解明2017

    • Author(s)
      宮野 悟
    • Organizer
      第226回生命科学フォーラム
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 人工知能で拓く未来の医療2017

    • Author(s)
      宮野 悟
    • Organizer
      第17回日本抗加齢医学会総会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Supercomputer Challenges for Cancer Genomics and TCR Data Analysis2017

    • Author(s)
      Satoru Miyano
    • Organizer
      Precision Cancer Biology: From Targeted to Immune Therapies
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] がんの医療と研究を進化させる人工知能とスパコン ~不可能に直面したとき人は進化する~2017

    • Author(s)
      宮野 悟
    • Organizer
      読売テクノ・フォーラム
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Cancer Clinical Sequence with Genomon and Watson for Genomics Using Supercomputers2017

    • Author(s)
      Satoru Miyano
    • Organizer
      International Conference on Precision Cancer Medicine
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 人知の増強(AI)とがんのゲノム医療2017

    • Author(s)
      宮野 悟
    • Organizer
      TM研究会2017 年度第4 回研究交流会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] スパコンと人工知能でがんの臨床シークエンス支援を新ステージへ2017

    • Author(s)
      宮野 悟
    • Organizer
      京都大学大学院薬学研究科医薬創成情報科学専攻10周年記念シンポジウム
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] ゲノムデータ解析パイプラインGenomonとがん臨床シークエンス研究2017

    • Author(s)
      宮野 悟
    • Organizer
      第6回生命医薬情報学連合大会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] AIとスパコンでが拓く新生命科学2017

    • Author(s)
      宮野 悟
    • Organizer
      京都バイオ計測センターシンポジウム
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] スパコンとAIでがんのシステム異常を暴き出す -ゲノムからネットワークまで-2017

    • Author(s)
      宮野 悟
    • Organizer
      第21回 薬物動態談話会セミナー
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Challenging Big Cancer Sequence Data by Supercomputer and Artificial Intelligence2017

    • Author(s)
      Satoru Miyano
    • Organizer
      DNA sequencing technologies and their application in practice
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] CHALLENGES FOR COMPLEXIY OF CANCER BY SUPERCOMPUTER -FROM GENOME TO NETWORK2017

    • Author(s)
      Satoru Miyano
    • Organizer
      第48回高松宮妃癌研究基金国際シンポジウム
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] AIによるがんの臨床シークエンス支援研究 -できること、できないこと、できそうなこと-2017

    • Author(s)
      宮野 悟
    • Organizer
      第15回医療機器フォーラム
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Breaking Cancer Big Data with Supercomputer and Artificial Intelligence2017

    • Author(s)
      宮野 悟
    • Organizer
      創立125周年・改組50周年記念国際シンポジウム
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 人工知能がもたらす新時代の医療診断支援2017

    • Author(s)
      宮野 悟
    • Organizer
      第17回抗加齢医学の実際2017
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] スーパーコンピュータと人工知能で加速するがんゲノミクスと臨床シークエンス研究2017

    • Author(s)
      宮野 悟
    • Organizer
      愛知県がんセンター特別招聘セミナー
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Challenging Cancer Omics Big Data with Supercomputers2017

    • Author(s)
      Satoru Miyano
    • Organizer
      2017年度生命科学系学会合同年次大会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Analyzing and Interpreting Cancer Big Data2017

    • Author(s)
      Miyano S
    • Organizer
      NSF Big Data PI Meeting
    • Place of Presentation
      Omni Shoreham Hotel, Washington DC, USA
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Challenging Cancer Omics Big Data with Supercomputers2017

    • Author(s)
      Miyano S
    • Organizer
      Computational Biology for Big Data: New Opportunities and Challenges
    • Place of Presentation
      Shanghai Information Center for Life Sciences, Shanghai, China
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Mining Gene Networks in Cancer by Supercomputers2016

    • Author(s)
      Satoru Miyano
    • Organizer
      Symposium of Biodynamical Systems
    • Place of Presentation
      South University of Science and Technology of China, Shenzhen, China
    • Year and Date
      2016-03-06
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Cancer Big Data Challenges with Supercomputers2016

    • Author(s)
      Miyano S
    • Organizer
      ISC 2016
    • Place of Presentation
      Frankfurt am, Germany
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Cancer Clinical Sequence Research with IBM Watson2016

    • Author(s)
      Miyano S
    • Organizer
      The 19th Annual Meeting of Korean Urogynecology Society
    • Place of Presentation
      Seoul, Korea
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Next-Generation Cancer Research with Artificial Intelligence2016

    • Author(s)
      Miyano S
    • Organizer
      The 3rd Meeting of the International Ovarian Cancer Consortium in conjunction with the International Symposium on Tumor Microenvironment and Therapeutic Resistance
    • Place of Presentation
      Oklahoma City, USA
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Understanding and Interpreting Cancer Big Data by Supercomputer and Artificial Intelligence2016

    • Author(s)
      Miyano S
    • Organizer
      The 16th IEEE International Conference on Bioinformatics and Bioengineering
    • Place of Presentation
      Taichung, Taiwan
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Boosting Systems Understanding of Cancer in New Dimension by Supercomputers2015

    • Author(s)
      Satoru Miyano
    • Organizer
      The 2015 CSHA/AACR Joint Conference “Big Data, Computation and Systems Biology in Cancer”
    • Place of Presentation
      Cold Spring Harbor Asia, Suzhou, China
    • Year and Date
      2015-12-03
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Cancer Genomes and Clinical Sequence2015

    • Author(s)
      Satoru Miyano
    • Organizer
      Princess Al Jawhara Center for Molecular Medicine: The 9th Scientific Conference
    • Place of Presentation
      The Arabic Gulf University, Manama, Bahrain
    • Year and Date
      2015-11-28
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] ゲノム個別化医療は医療費を削減できるか2015

    • Author(s)
      宮野 悟
    • Organizer
      日本癌治療学会学術総会
    • Place of Presentation
      国立京都国際会館(京都府京都市)
    • Year and Date
      2015-10-30
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 「京」、及びポスト「京」がブーストするがんビッグデータ解析2015

    • Author(s)
      宮野 悟
    • Organizer
      生命医薬情報学連合大会 2015 年大会
    • Place of Presentation
      京都大学宇治キャンパスおうばくプラザ(京都府宇治市)
    • Year and Date
      2015-10-30
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] スーパーコンピュータが暴き出したがんのシステム異常2015

    • Author(s)
      宮野 悟
    • Organizer
      日本癌治療学会学術総会
    • Place of Presentation
      国立京都国際会館(京都府京都市)
    • Year and Date
      2015-10-29
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Unraveling cancer heterogeneity with supercomputer2015

    • Author(s)
      Satoru Miyano
    • Organizer
      The 53rd Annual Meeting of the Biophysical Society of Japan
    • Place of Presentation
      Kanazawa University, Kanazawa, Ishikawa, Japan
    • Year and Date
      2015-09-13
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Boosting Systems Understanding of Cancer into Another Dimension2015

    • Author(s)
      Satoru Miyano
    • Organizer
      QBiC Symposium 2015: High-Dimensional Data for the Design Principles of Life
    • Place of Presentation
      RIKEN Quantitative Biology Center (QBiC), Osaka, Japan
    • Year and Date
      2015-08-25
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Analyzing Cancer Gene Networks with Supercomputers2015

    • Author(s)
      Satoru Miyano
    • Organizer
      The 2nd Annual Meeting of the International Ovarian Cancer Consortium and the Symposium on Tumor Microenvironment and Therapy Resistance
    • Place of Presentation
      Stephenson Cancer Center, Oklahoma City, USA
    • Year and Date
      2015-08-17
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Supercomputers for Cancer Research and Cancer Big Data2015

    • Author(s)
      Satoru Miyano
    • Organizer
      The 4th IIAI International Congress on Advanced Applied Informatics
    • Place of Presentation
      Okayama Convention Center, Okayama, Japan
    • Year and Date
      2015-07-13
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Remarks]

    • URL

      http://neosystemscancer.hgc.jp/

    • Related Report
      2018 Annual Research Report
  • [Remarks]

    • URL

      http://genomon-project.github.io/GenomonPages/

    • Related Report
      2018 Annual Research Report
  • [Remarks]

    • URL

      https://github.com/Genomon-Project/paplot/

    • Related Report
      2018 Annual Research Report
  • [Remarks]

    • URL

      https://github.com/tshimam/gimlet/

    • Related Report
      2018 Annual Research Report
  • [Remarks]

    • URL

      http://sign.hgc.jp/signbn/index_ja.html

    • Related Report
      2018 Annual Research Report
  • [Remarks] 新学術領域「システム癌新次元」

    • URL

      http://neosystemscancer.hgc.jp/

    • Related Report
      2017 Annual Research Report
  • [Remarks] Genomon Project

    • URL

      http://genomon-project.github.io/GenomonPages/

    • Related Report
      2017 Annual Research Report
  • [Remarks] PAPLOT

    • URL

      https://github.com/Genomon-Project/paplot/

    • Related Report
      2017 Annual Research Report
  • [Remarks] GIMLET

    • URL

      https://github.com/tshimam/gimlet/

    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
  • [Remarks] SiGN-BN

    • URL

      http://sign.hgc.jp/signbn/index_ja.html

    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
  • [Remarks] Genomon

    • Related Report
      2016 Annual Research Report
  • [Remarks] D3M

    • URL

      https://github.com/ymatts/D3M

    • Related Report
      2016 Annual Research Report
  • [Remarks] SiGN-L1

    • URL

      http://sign.hgc.jp/signl1/

    • Related Report
      2016 Annual Research Report
  • [Remarks] GenomonPipeline

    • URL

      https://github.com/Genomon-Project/GenomonPipeline

    • Related Report
      2015 Annual Research Report
  • [Remarks] Genomon

    • URL

      http://genomon.hgc.jp/exome/index.html

    • Related Report
      2015 Annual Research Report
  • [Remarks] Genomon-fusion

    • URL

      http://genomon.hgc.jp/rna/

    • Related Report
      2015 Annual Research Report
  • [Remarks] GenomonMutationFilter

    • URL

      https://github.com/Genomon-Project/GenomonMutationFilter

    • Related Report
      2015 Annual Research Report
  • [Remarks] GenomonSV

    • URL

      https://github.com/Genomon-Project/GenomonSV

    • Related Report
      2015 Annual Research Report

URL: 

Published: 2015-07-02   Modified: 2019-12-27  

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