| Budget Amount *help |
¥246,480,000 (Direct Cost: ¥189,600,000、Indirect Cost: ¥56,880,000)
Fiscal Year 2019: ¥44,330,000 (Direct Cost: ¥34,100,000、Indirect Cost: ¥10,230,000)
Fiscal Year 2018: ¥44,200,000 (Direct Cost: ¥34,000,000、Indirect Cost: ¥10,200,000)
Fiscal Year 2017: ¥42,510,000 (Direct Cost: ¥32,700,000、Indirect Cost: ¥9,810,000)
Fiscal Year 2016: ¥42,900,000 (Direct Cost: ¥33,000,000、Indirect Cost: ¥9,900,000)
Fiscal Year 2015: ¥72,540,000 (Direct Cost: ¥55,800,000、Indirect Cost: ¥16,740,000)
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| Outline of Final Research Achievements |
We cloned the thermosensitive TRP channel genes from different species and analyzed their functions. This contributed to the understanding how we animals adapted the changes in environment temperature by changing the expression and function of thermosensitive TRP channels in the evolutional process. And we identified the domains of the thermosensitive TRP channels involved in the temperature sensation. In addition, we clarified the physiological significance of thermosensitive TRP channels using TRP channel-deficient mice (Tominaga). We also clarified the mechanisms for localization of receptor proteins on the plasma membrane, and the effects of temperature and membrane fluidity (Takagi). We clarified the mechanisms for thermosensation in C. Elegans and identified a novel trimer G-protein-coupled receptor involved in thermosensation (Kuhara). We analyzed the functions of purified thermosensitive TRP channel proteins incorporated into a planar lipid bilayer (Uchida).
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