| Budget Amount *help |
¥103,740,000 (Direct Cost: ¥79,800,000、Indirect Cost: ¥23,940,000)
Fiscal Year 2019: ¥18,460,000 (Direct Cost: ¥14,200,000、Indirect Cost: ¥4,260,000)
Fiscal Year 2018: ¥18,590,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥4,290,000)
Fiscal Year 2017: ¥18,590,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥4,290,000)
Fiscal Year 2016: ¥18,590,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥4,290,000)
Fiscal Year 2015: ¥29,510,000 (Direct Cost: ¥22,700,000、Indirect Cost: ¥6,810,000)
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| Outline of Final Research Achievements |
To elucidate the role of the circadian clock mechanism in temperature sensing, temperature response, and body temperature control in animals, we established a simple method of detecting temperature-dependent clock protein variation (Tainaka et al., Chronobiol Int 2018) and identified the G-protein-coupled receptor CALCR in the master circadian pacemaker in the brain as a component required for body temperature attenuation during napping (Doi et al., Nat Commun 2016; Goda & Doi et al., Genes Dev 2018). Furthermore, we developed mutant mice carrying a mutation only at the E′-box cis-element in the promoter region of the core clock gene Per2, and revealed, for the first time, the extent of the impact of the non-coding cis-element in daily maintenance of animal body temperature rhythmicity (Doi et al., Nat Commun 2019).
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