| Budget Amount *help |
¥84,110,000 (Direct Cost: ¥64,700,000、Indirect Cost: ¥19,410,000)
Fiscal Year 2019: ¥13,910,000 (Direct Cost: ¥10,700,000、Indirect Cost: ¥3,210,000)
Fiscal Year 2018: ¥13,910,000 (Direct Cost: ¥10,700,000、Indirect Cost: ¥3,210,000)
Fiscal Year 2017: ¥13,910,000 (Direct Cost: ¥10,700,000、Indirect Cost: ¥3,210,000)
Fiscal Year 2016: ¥13,910,000 (Direct Cost: ¥10,700,000、Indirect Cost: ¥3,210,000)
Fiscal Year 2015: ¥28,470,000 (Direct Cost: ¥21,900,000、Indirect Cost: ¥6,570,000)
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| Outline of Final Research Achievements |
The purpose of this study is to investigate the mechanism by which the C. elegans mechanosensor molecule/neuronal system adapts to changes in muscle and metabolism under space experiments and various culture conditions on the ground. As a result, in C. elegans grown under space microgravity, both gene and protein expression levels for muscular thick filaments, cytoskeletal elements, and mitochondrial metabolic enzymes decreased relative to parallel cultures on the 1G centrifuge. In addition, a growth factor BMP released from motor nerves and sensory nerve dopamine are reduced in the spaceflown C. elegans. Furthermore, the mechanism from mitochondrial damage to muscle atrophy has been demonstrated that Ca2+ overaccumulation in the muscular cells, activation of furin and MMPs, and ECM degradation are the major processes of muscle collapse.
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