| Co-Investigator(Kenkyū-buntansha) |
白川 正輝 国立研究開発法人宇宙航空研究開発機構, 有人宇宙技術部門, 主幹研究開発員 (30624522)
内田 智子 一般財団法人日本宇宙フォーラム, 宇宙利用事業部, 研究員 (90724964)
佐藤 文規 京都大学, 健康長寿社会の総合医療開発ユニット, 特定助教 (10588263)
飯田 敦夫 京都大学, 再生医科学研究所, 助教 (90437278)
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| Budget Amount *help |
¥95,030,000 (Direct Cost: ¥73,100,000、Indirect Cost: ¥21,930,000)
Fiscal Year 2019: ¥16,640,000 (Direct Cost: ¥12,800,000、Indirect Cost: ¥3,840,000)
Fiscal Year 2018: ¥16,640,000 (Direct Cost: ¥12,800,000、Indirect Cost: ¥3,840,000)
Fiscal Year 2017: ¥16,640,000 (Direct Cost: ¥12,800,000、Indirect Cost: ¥3,840,000)
Fiscal Year 2016: ¥16,640,000 (Direct Cost: ¥12,800,000、Indirect Cost: ¥3,840,000)
Fiscal Year 2015: ¥28,470,000 (Direct Cost: ¥21,900,000、Indirect Cost: ¥6,570,000)
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| Outline of Final Research Achievements |
Questions what causes muscle atrophy in space and how skeletal muscles achieve adaptation to the gravitational changes remain unknown. While comparison of animal samples before and after space stays are essential to understand mechanisms of muscle atrophy in space and its recovery after the return, difficulty in fresh muscle sampling of higher vertebrates in ISS has hampered acquisition of accurate information from those animals. In this study, we found that space stay causes skeletal muscle atrophy also in zebrafish, aquatic vertebrate and that they quickly learn how to swim in the microgravity. Comparison of transcriptome profiles with RNA-seq obtained from individual zebrafish during space stay and those after return to the earth uncovers clusters of genes that are regulated in location-sensitive manners.
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