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Integrated understanding of plastic alteration of vestibular system and countermeasures for adaptive disorder

Planned Research

Project Area"LIVING IN SPACE" - Integral Understanding of life-regulation mechanism from "SPACE"
Project/Area Number 15H05940
Research Category

Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

Allocation TypeSingle-year Grants
Review Section Complex systems
Research InstitutionGifu University

Principal Investigator

Morita Hironobu  岐阜大学, 大学院医学系研究科, 教授 (80145044)

Co-Investigator(Kenkyū-buntansha) 梶 博史  近畿大学, 医学部, 教授 (90346255)
上田 陽一  産業医科大学, 医学部, 教授 (10232745)
岩崎 真一  東京大学, 医学部附属病院, 准教授 (10359606)
村谷 匡史  筑波大学, 医学医療系, 教授 (50730199)
Project Period (FY) 2015-06-29 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥95,030,000 (Direct Cost: ¥73,100,000、Indirect Cost: ¥21,930,000)
Fiscal Year 2019: ¥16,640,000 (Direct Cost: ¥12,800,000、Indirect Cost: ¥3,840,000)
Fiscal Year 2018: ¥16,640,000 (Direct Cost: ¥12,800,000、Indirect Cost: ¥3,840,000)
Fiscal Year 2017: ¥16,640,000 (Direct Cost: ¥12,800,000、Indirect Cost: ¥3,840,000)
Fiscal Year 2016: ¥16,640,000 (Direct Cost: ¥12,800,000、Indirect Cost: ¥3,840,000)
Fiscal Year 2015: ¥28,470,000 (Direct Cost: ¥21,900,000、Indirect Cost: ¥6,570,000)
Keywords耳石前庭系 / 可塑的変化 / 筋-骨連関 / 球形嚢 / 前庭神経核 / 前庭電気刺激 / 平衡機能障害 / 起立性低血圧 / 前庭系 / 過重力 / 微小重力 / ノイズGVS / 筋・骨連関 / 糖・エネルギー代謝 / 自律神経 / 平衡機能 / 尾懸垂 / 糖代謝 / 重力環境 / 前庭系可塑性 / 前庭系適応障害 / 筋・骨連携 / 摂食関連ペプチド / noise-GVS / 前庭-血圧反射 / 宇宙飛行士 / 可塑性 / 適応障害 / 前庭系の可塑性 / ストレス反応 / 筋萎縮 / 骨量減少 / 宇宙医学 / 重力生理学 / 環境生理学 / 分子遺伝学
Outline of Final Research Achievements

Under the hypothesis that plastic changes in the otolith vestibular system, which is a sensing organ of gravity, are involved in the causes of various medical problems associated with microgravity, we investigated the changes in otolith sensory cells and vestibular nuclei, which are primary neurons, caused by the microgravity environment, and obtained the following results.
In addition to previously known functions, the vestibular system is involved in various body function regulation such as feeding, glucose metabolism, body temperature, blood pressure, regulation of muscle mass/bone mass. These functions change when exposed to different gravitational environments with strong plasticity. This plastic change involves changes in gene expression in the saccule and vestibular nuclei. It was suggested that the method of electrically stimulating the vestibular system might be useful as a countermeasure against plastic changes.

Academic Significance and Societal Importance of the Research Achievements

「宇宙は老化のアクセラレータである」と言われるように,宇宙飛行に伴う医学的問題―平衡機能障害,起立性低血圧,筋量・骨量減少―は高齢者にもみられる症状であり,高齢者において活動量減少に伴う前庭への入力減少により,前庭機能が低下して,これらの症状を引き起こしている可能性がある。実際,高齢者では,前庭-血圧反射の調節力が大きく損なわれており,それが起立性低血圧の原因となっている。本研究成果は,重力変化に対する生体適応を理解し,それによって引き起こされる医学的問題の発症機序解明に貢献し,宇宙飛行士の健康増進法を提案したのみならず,この方法を高齢者に適応し,QOL改善につなげる可能性が示唆された。

Report

(6 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Annual Research Report
  • 2017 Annual Research Report
  • 2016 Annual Research Report
  • 2015 Annual Research Report
  • Research Products

    (76 results)

All 2020 2019 2018 2017 2016 2015 Other

All Int'l Joint Research (1 results) Journal Article (37 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 37 results,  Open Access: 26 results,  Acknowledgement Compliant: 6 results) Presentation (35 results) (of which Int'l Joint Research: 23 results,  Invited: 7 results) Remarks (3 results)

  • [Int'l Joint Research] Virginia State University/Florida State University(米国)

    • Related Report
      2016 Annual Research Report
  • [Journal Article] Roles of olfactomedin 1 in muscle and bone alterations induced by gravity change in mice2020

    • Author(s)
      Shimode T, Kawao N, Morita H, Ishida M, Takafuji Y, Kaji H
    • Journal Title

      Calcified Tissue International

      Volume: 27 Issue: 2 Pages: 180-190

    • DOI

      10.1007/s00223-020-00710-6

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] VGLUT2-expressing neurons in the vestibular nuclear complex mediate gravitational stress-induced hypothermia in mice2020

    • Author(s)
      Abe C, Yamaoka Y, Maejima Y, Mikami T, Yokota S, Yamanaka A, Morita H
    • Journal Title

      Communications Biology

      Volume: 227 Issue: 1 Pages: 1-13

    • DOI

      10.1038/s42003-020-0950-0

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Roles of Dkk2 in the linkage from muscle to bone during mechanical unloading in mice2020

    • Author(s)
      Kawao N, Morita H, Iemura S, Ishida M, Kaji H
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 21 Issue: 7 Pages: 2547-2547

    • DOI

      10.3390/ijms21072547

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Understanding vestibular-related physiological functions could provide clues on adapting to a new gravitational environment2020

    • Author(s)
      Morita H, Kaji H, Ueta Y, Abe C
    • Journal Title

      Journal of Physiological Sciences

      Volume: 70 Issue: 1 Pages: 17-17

    • DOI

      10.1186/s12576-020-00744-3

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Role of irisin in androgen-deficient muscle wasting and osteopenia in mice.2020

    • Author(s)
      Iemura S, Kawao N, Okumoto K, Akagi M, Kaji H.
    • Journal Title

      J Bone Miner Metab

      Volume: 38 Issue: 2 Pages: 161-171

    • DOI

      10.1007/s00774-019-01043-7

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hypergravity-induced plastic alteration of the vestibulo-sympathetic reflex involves decrease in responsiveness of CAMK2-expressing neurons in the vestibular nuclear complex2019

    • Author(s)
      Abe C, Yamaoka Y, Maejima Y, Mikami T, Morita H
    • Journal Title

      Journal of Physiological Sciences

      Volume: 69 Issue: 6 Pages: 903-917

    • DOI

      10.1007/s12576-019-00705-5

    • NAID

      40022093973

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Noisy galvanic vestibular stimulation has a greater ameliorating effect on posture in unstable subjects: a feasibility study2019

    • Author(s)
      Fujimoto Chisato、Kinoshita Makoto、Kamogashira Teru、Egami Naoya、Kawahara Takuya、Uemura Yukari、Yamamoto Yoshiharu、Yamasoba Tatsuya、Iwasaki Shinichi
    • Journal Title

      Scientific Reports

      Volume: 9 Issue: 1 Pages: 7-7

    • DOI

      10.1038/s41598-019-53834-7

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Alteration of Musashi1 Intra-cellular Distribution During Regeneration Following Gentamicin-Induced Hair Cell Loss in the Guinea Pig Crista Ampullaris2019

    • Author(s)
      Kinoshita Makoto、Fujimoto Chisato、Iwasaki Shinichi、Kashio Akinori、Kikkawa Yayoi S.、Kondo Kenji、Okano Hideyuki、Yamasoba Tatsuya
    • Journal Title

      Frontiers in Cellular Neuroscience

      Volume: 13 Pages: 481-481

    • DOI

      10.3389/fncel.2019.00481

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Roles of leptin in the recovery of muscle and bone by reloading after mechanical unloading in high fat diet-fed obese mice.2019

    • Author(s)
      Kawao N, Ishida M, Kaji H.
    • Journal Title

      PLoS One

      Volume: 14 Issue: 10 Pages: e0224403-e0224403

    • DOI

      10.1371/journal.pone.0224403

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Expression of the genes encoding hypothalamic feeding-related neuropeptides in the streptozotocin-induced diabetic rats with variable hyperglycemia and hyperphagia2019

    • Author(s)
      Sonoda Satomi、Yoshimura Mitsuhiro、Ueno Hiromichi、Nishimura Haruki、Nishimura Kazuaki、Tanaka Kentaro、Motojima Yasuhito、Saito Reiko、Maruyama Takashi、Hashimoto Hirofumi、Okada Yosuke、Tanaka Yoshiya、Ueta Yoichi
    • Journal Title

      Neuropeptides

      Volume: 印刷中 Pages: 34-40

    • DOI

      10.1016/j.npep.2019.03.003

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Progression of Peripheral Vestibular Dysfunctions in Patients With a Mitochondrial A3243G Mutation2019

    • Author(s)
      Inoue Aki、Iwasaki Shinichi、Fujimoto Chisato、Kinoshita Makoto、Yamasoba Tatsuya
    • Journal Title

      Otology & Neurotology

      Volume: 40 Issue: 3 Pages: 359-364

    • DOI

      10.1097/mao.0000000000002091

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Advanced genetic and viral methods for labelling and manipulation of oxytocin and vasopressin neurones in rats2018

    • Author(s)
      Yoshimura Mitsuhiro、Ueta Yoichi
    • Journal Title

      Cell and Tissue Research

      Volume: 375 Issue: 1 Pages: 311-327

    • DOI

      10.1007/s00441-018-2932-9

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of hypergravity on the gene expression of the hypothalamic feeding-related neuropeptides in mice via vestibular inputs.2018

    • Author(s)
      Sonoda S, Yoshimura M, Abe C, Morita H, Ueno H, Motojima Y, Saito R, Maruyama T, Hashimoto H, Tanaka Y, Ueta Y.
    • Journal Title

      Peptides

      Volume: 105 Pages: 14-20

    • DOI

      10.1016/j.peptides.2018.05.004

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Plasminogen activator inhibitor‐1 deficiency suppresses osteoblastic differentiation of mesenchymal stem cells in mice2018

    • Author(s)
      Takafuji Yoshimasa、Tatsumi Kohei、Ishida Masayoshi、Kawao Naoyuki、Okada Kiyotaka、Matsuo Osamu、Kaji Hiroshi
    • Journal Title

      Journal of Cellular Physiology

      Volume: 234 Issue: 6 Pages: 9687-9697

    • DOI

      10.1002/jcp.27655

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Serpina3n, dominantly expressed in female osteoblasts, suppresses the phenotypes of differentiated osteoblasts in mice.2018

    • Author(s)
      Ishida M, Kawao N, Okada K, Tatsumi K, Sakai K, Nishio K, Kaji H.
    • Journal Title

      Endocrinology

      Volume: 159 Pages: 3775-3790

    • DOI

      10.1210/en.2018-00639

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Plasminogen activator inhibitor-1 is involved in interleukin-1β-induced matrix metalloproteinase expression in murine chondrocytes.2018

    • Author(s)
      Moritake A, Kawao N, Okada K, Ishida M, Tatsumi K, Matsuo O, Akagi M, Kaji H.
    • Journal Title

      Mod Rheumatol

      Volume: 28 Issue: 6 Pages: 1-5

    • DOI

      10.1080/14397595.2018.1525018

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Noisy Galvanic Vestibular Stimulation Sustainably Improves Posture in Bilateral Vestibulopathy2018

    • Author(s)
      Fujimoto Chisato、Egami Naoya、Kawahara Takuya、Uemura Yukari、Yamamoto Yoshiharu、Yamasoba Tatsuya、Iwasaki Shinichi
    • Journal Title

      Frontiers in Neurology

      Volume: 9 Pages: 900-900

    • DOI

      10.3389/fneur.2018.00900

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Noisy vestibular stimulation increases gait speed in normals and in bilateral vestibulopathy2018

    • Author(s)
      Iwasaki Shinichi、Fujimoto Chisato、Egami Naoya、Kinoshita Makoto、Togo Fumiharu、Yamamoto Yoshiharu、Yamasoba Tatsuya
    • Journal Title

      Brain Stimulation

      Volume: - Issue: 4 Pages: 709-715

    • DOI

      10.1016/j.brs.2018.03.005

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Aging Is a Risk Factor for Utricular Dysfunction in Idiopathic Benign Paroxysmal Positional Vertigo2018

    • Author(s)
      Fujimoto Chisato、Kawahara Takuya、Kinoshita Makoto、Kikkawa Yayoi S.、Sugasawa Keiko、Yagi Masato、Yamasoba Tatsuya、Iwasaki Shinichi、Murofushi Toshihisa
    • Journal Title

      Frontiers in Neurology

      Volume: 9 Pages: 1049-1049

    • DOI

      10.3389/fneur.2018.01049

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Role of follistatin in muscle and bone alterations induced by gravity change in mice.2018

    • Author(s)
      Kawao N, Morita H, Obata K, Tatsumi K, Kaji H.
    • Journal Title

      J Cell Physiol.

      Volume: 233 Issue: 2 Pages: 1191-1201

    • DOI

      10.1002/jcp.25986

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Clinical features of otolith organ-specific vestibular dysfunction2018

    • Author(s)
      Fujimoto C, Suzuki S, Kinoshita M, Egami N, Sugasawa K, Iwasaki S
    • Journal Title

      Clinical Neurophysiology

      Volume: 129 Issue: 1 Pages: 238-245

    • DOI

      10.1016/j.clinph.2017.11.006

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Roles of irisin in the linkage from muscle to bone during mechanical unloading in mice2018

    • Author(s)
      Kawao N, Moritake A, Tatsumi K, Kaji H
    • Journal Title

      Calcified Tissue International

      Volume: - Issue: 1 Pages: 24-34

    • DOI

      10.1007/s00223-018-0387-3

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Role of Macrophages and Plasminogen Activator Inhibitor-1 in Delayed Bone Repair in Diabetic Female Mice2018

    • Author(s)
      Shimoide Takeshi、Kawao Naoyuki、Tamura Yukinori、Okada Kiyotaka、Horiuchi Yoshitaka、Okumoto Katsumi、Kurashimo Shinji、Ishida Masayoshi、Tatsumi Kohei、Matsuo Osamu、Kaji Hiroshi
    • Journal Title

      Endocrinology

      Volume: 159 Issue: 4 Pages: 1875-1885

    • DOI

      10.1210/en.2018-00085

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effects of hypergravity on gene levels in anti-gravity muscle and bone through the vestibular system in mice.2017

    • Author(s)
      Kawao N, Morita H, Nishida K, Obata K, Tatsumi K, Kaji H.
    • Journal Title

      J Physiol Sci.

      Volume: - Issue: 5 Pages: 609-616

    • DOI

      10.1007/s12576-017-0566-4

    • NAID

      40021645358

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Impact of a simulated gravity load for atmospheric reentry, 10 g for 2 min, on conscious mice2017

    • Author(s)
      Morita H, Yamaguchi A, Shiba D, Shirakawa M and Takahashi S
    • Journal Title

      Journal of Physiological Sciences

      Volume: Epub ahead of print Issue: 4 Pages: 531-537

    • DOI

      10.1007/s12576-017-0526-z

    • NAID

      40021238561

    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Increased oxytocin-monomeric red fluorescent protein 1 fluorescent intensity with urocortin-like immunoreactivity in the hypothalamo-neurohypophysial system of aged transgenic rats2017

    • Author(s)
      Ohno S, Hashimoto H, Fujihara H, Fujiki N, Yoshimura M, Maruyama T, Motojima Y, Saito R, Ueno H, Sonoda S, Ohno M, Umezu Y, Hamamura A, Saeki S, Ueta Y
    • Journal Title

      Neuroscience Research

      Volume: 128 Pages: 40-49

    • DOI

      10.1016/j.neures.2017.08.001

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Activation of endogenous arginine vasopressin neurons inhibit food intake: by using a novel transgenic rat line with DREADDs system2017

    • Author(s)
      Yoshimura Mitsuhiro、Nishimura Kazuaki、Nishimura Haruki、Sonoda Satomi、Ueno Hiromichi、Motojima Yasuhito、Saito Reiko、Maruyama Takashi、Nonaka Yuki、Ueta Yoichi
    • Journal Title

      Scientific Reports

      Volume: 7 Issue: 1 Pages: 15728-15728

    • DOI

      10.1038/s41598-017-16049-2

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effect of Noisy Galvanic Vestibular Stimulation on Ocular Vestibular-Evoked Myogenic Potentials to Bone-Conducted Vibration2017

    • Author(s)
      Iwasaki S, Karino S, Kamogashira T, Togo F, Fujimoto C, Yamamoto Y, Yamasoba T
    • Journal Title

      Front Neurol

      Volume: 8 Pages: 26-26

    • DOI

      10.3389/fneur.2017.00026

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effects of peripheral vestibular dysfunction on dynamic postural stability measured by the functional reach test and timed up and go test2017

    • Author(s)
      Nishi T, Kamogashira T, Fujimoto C, Kinoshita M, Egami N, Sugasawa K, Yamasoba T, Iwasaki S
    • Journal Title

      Annals of Otology, Rhinology & Laryngology

      Volume: 126 Issue: 6 Pages: 438-444

    • DOI

      10.1177/0003489417700439

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Comparison among ultrasonic, electrical apparatus, and toxic chemicals for vestibular lesion in mice2017

    • Author(s)
      Yamaoka Y, Abe C, Morita H
    • Journal Title

      Journal of Neuroscience Methods

      Volume: 295 Pages: 58-67

    • DOI

      10.1016/j.jneumeth.2017.11.021

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Novel roles of FKBP5 in muscle alteration induced by gravity change in mice2016

    • Author(s)
      Shimode T, Kawao N, Tamura Y, Morita H and Kaji H
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 479 Issue: 3 Pages: 602-606

    • DOI

      10.1016/j.bbrc.2016.09.126

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] The vestibular system is critical for the changes in muscle and bone induced by hypergravity2016

    • Author(s)
      Kawao N, Morita H, Obata K, Tamura Y, Okumoto K and Kaji H
    • Journal Title

      Physiological Reports

      Volume: 4(19) Issue: 19 Pages: 12979-12979

    • DOI

      10.14814/phy2.12979

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Long-term exposure to microgravity impairs vestibulo-cardiovascular reflex2016

    • Author(s)
      Morita H, Abe C and Tanaka K
    • Journal Title

      Scientific Reports

      Volume: 6 Issue: 1 Pages: 33405-33405

    • DOI

      10.1038/srep33405

    • NAID

      120007017301

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Ground-based assessment of JAXA mouse habitat cage unit by mouse phenotypic studies2016

    • Author(s)
      Shimbo M, Kudo T, Akiyama T, Akiyama N, Sasanuma H, Yoshida N, Zhou R, Wang YY, Ito T, Kokubu Y, Noguchi TA, Ishimine H, Kurisaki A, Shiba D, Mizuno H, Shirakawa M, Ito N, Takeda S, Takahashi S.(他22名25番目)
    • Journal Title

      Experimental Animals

      Volume: 65 Issue: 2 Pages: 175-187

    • DOI

      10.1538/expanim.15-0077

    • NAID

      130005152402

    • ISSN
      0007-5124, 1341-1357, 1881-7122
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Hypergravity provokes a temporary reduction in CD4+CD8+ thymocyte number and a persistent decrease in medullary thymic epithelial cell frequency in mice.2015

    • Author(s)
      Tateishi R, Akiyama N, Miyauchi M, Yoshinaga R, Sasanuma H, Kudo T, Shimbo M, Shinohara M, Obata K, Inoue J, Shirakawa M, Shiba D, Asahara H, Yoshida N, Takahashi S, Morita H, Akiyama T
    • Journal Title

      PLOS ONE

      Volume: 10 Issue: 10 Pages: 1-17

    • DOI

      10.1371/journal.pone.0141650

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Role of osteoclasts in the heterotopic ossification enhanced by fibrodysplasia ossificans progressiva-related activin-like kinase 2 mutation in mice.2015

    • Author(s)
      Kawao N, Kaji H, et al.
    • Journal Title

      J Bone Miner Metab

      Volume: Epub ahead of print Issue: 5 Pages: 1-9

    • DOI

      10.1007/s00774-015-0701-3

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Feasibility of a short-arm centrifuge for mouse hypergravity experiments2015

    • Author(s)
      Morita H, et al.
    • Journal Title

      PLOS ONE

      Volume: 10(7): e133981 Issue: 7 Pages: 1-14

    • DOI

      10.1371/journal.pone.0133981

    • NAID

      120007136296

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] Effects of the gene expression of hypothalamic feeding-regulating neuropeptides after being exposed to different gravity in mice via vestibular inputs2019

    • Author(s)
      Sonoda S, Yoshimura M, Baba K, Sanada K, Nishimura K, Nishimura H, Tanaka K, Maruyama T, Abe C, Morita H, Ueta Y
    • Organizer
      Neuroscience of Energy Balance
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Ameliorating effect of noisy galvanic vestibular stimulation on postural stability is greater in originally more unstable subjects2019

    • Author(s)
      Iwasaki S
    • Organizer
      Annual CORLAS Meeting
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 長期宇宙滞在による耳石器の可塑的変化2019

    • Author(s)
      森田啓之,安部力,村谷匡史
    • Organizer
      第33回日本宇宙生物科学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 重力生理学:動物実験から被験者実験へ2019

    • Author(s)
      森田啓之
    • Organizer
      第53回日本実験動物技術者協会総会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] Gravity change and muscle/bone relationship2019

    • Author(s)
      梶博史
    • Organizer
      第37回日本骨代謝学会学術集会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 重力変化に伴うマウス視床下部摂食関連ペプチド遺伝子発現の変化2019

    • Author(s)
      園田里美, 吉村充弘, 橋本弘史, 丸山崇, 安部力, 森田啓之, 上田陽一
    • Organizer
      第37回日本骨代謝学会学術集会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 宇宙で快適に生きるために:前庭系の可塑的変化2019

    • Author(s)
      森田啓之
    • Organizer
      第72回日本自律神経学会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] ラバー負荷検査による前庭障害の診断とノイズ前庭電気刺激による治療2019

    • Author(s)
      岩﨑真一
    • Organizer
      大阪ExcellENT2019
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] Roles of macrophages and PAI-1 in diabetic delayed bone repair in female mice2019

    • Author(s)
      Kawao N
    • Organizer
      9th Federation of the Asian and Oceanian Physiological Societies
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Dominantly expressed Serpina3n suppresses the phenotypes of osteoblasts of female mice2019

    • Author(s)
      Ishida M
    • Organizer
      9th Federation of the Asian and Oceanian Physiological Societies
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] PAI-1 is crucial in osteoblastic differentiation of mesenchymal stem cells2019

    • Author(s)
      Takafuji Y
    • Organizer
      9th Federation of the Asian and Oceanian Physiological Societies
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] The hypothalamic feeding-related neuropeptides in the streptozotocin-induced diabetic rat2019

    • Author(s)
      Sonoda S
    • Organizer
      9th Federation of the Asian and Oceanian Physiological Societies
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Fos expression in the hypothalamic nuclei after changes from hypergravity to normal gravity in mice2019

    • Author(s)
      Ueta Y
    • Organizer
      9th Federation of the Asian and Oceanian Physiological Societies
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Impact of long-term stay in micro-gravity on vestibular function2019

    • Author(s)
      Morita H
    • Organizer
      9th Federation of the Asian and Oceanian Physiological Societies
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Chemogenetic activation of endogenous vasopressin neurons inhibit food intake2018

    • Author(s)
      Yoshimura M
    • Organizer
      9th International Congress of Neuroendocrinology
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] The hypothalamic feeding-regulating neuropeptides in the streptozotocin-induced diabetic rat2018

    • Author(s)
      Sonoda S
    • Organizer
      9th International Congress of Neuroendocrinology
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Effects of hypergravity on the gene expression of the hypothalamic feedingrelated neuropeptides in mice via vestibular inputs2018

    • Author(s)
      Ueta Y
    • Organizer
      9th International Congress of Neuroendocrinology
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Frequency characteristics of somatoform vertigo and dizziness, bilateral vestibulopathy, and spinocerebellar degeneration2018

    • Author(s)
      Iwasaki S
    • Organizer
      Annual CORLAS Meeting
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Effects of long-term noisy vestibular stimulation on body balance in bilateral vestibulopathy2018

    • Author(s)
      Iwasaki S
    • Organizer
      XXX Barany Society Meeting
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 60周年記念シンポジウム「前庭刺激検査の過去と未来」Video head impulse testの原理と実際2018

    • Author(s)
      岩﨑真一
    • Organizer
      第77回日本めまい平衡医学会総会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Video head impulse test (vHIT) のコツとピットフォール2018

    • Author(s)
      岩﨑真一
    • Organizer
      第28回日本耳科学会総会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Long term effects of noisy galvanic vestibular stimulation on postural stability in elderly adult2017

    • Author(s)
      Iwasaki S
    • Organizer
      IFOS ENT World Congress
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Fos expression in the hypothalamus and brainstem after tail suspension in rats2017

    • Author(s)
      Maruyama T
    • Organizer
      International Behavioral Neuroscience Society
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Effect of vestibular lesion on hypothalamic feeding-regulating neuropeptides after being exposed to hyper gravity in mice2017

    • Author(s)
      Sonoda S
    • Organizer
      International Behavioral Neuroscience Society
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Transgenic approaches to regulate the neuronal activity in rat vasopressin neuron2017

    • Author(s)
      Yoshimura M
    • Organizer
      International Behavioral Neuroscience Society
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Transgenic approaches to regulate the neuronal activity in rat vasopressin neuron by using Optogenetics and DREADDs technology2017

    • Author(s)
      Yoshimura M
    • Organizer
      12th World Congress on Neurohypophysial Hormones
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Novel transgenic rat lines regulating the neuronal activity in rat vasopressin neuron by using Optogenetics and DREADDs technology2017

    • Author(s)
      Yoshimura M
    • Organizer
      International Society for Autonomic Neuroscience
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] C1 neurons mediate a stress-induced protection of renal ischemia/reperfusion injury2017

    • Author(s)
      Abe C
    • Organizer
      International Society for Autonomic Neuroscience
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Long-term exposure to microgravity impairs head-up tilt-induced vestibulo- cardiovascular reflex2017

    • Author(s)
      Morita H
    • Organizer
      International Society for Autonomic Neuroscience
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Muscle-derived factor affecting bone metabolism2016

    • Author(s)
      Kaji H
    • Organizer
      The 4th Seoul International Congress of Endocrinology and Metabolism
    • Place of Presentation
      Seoul, South Korea
    • Year and Date
      2016-04-28
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Hypergravity affects muscle and bone through the vestibular system in mice.2016

    • Author(s)
      Kawao N, Morita H, Obata K, Tamura Y, Okumoto K, Kaji H
    • Organizer
      第93回日本生理学会大会
    • Place of Presentation
      札幌
    • Year and Date
      2016-03-22
    • Related Report
      2015 Annual Research Report
  • [Presentation] Impact of long term spaceflight on arterial pressure regulation upon head-up tilt.2016

    • Author(s)
      Morita H, Abe C, Tanaka K
    • Organizer
      第93回日本生理学会大会
    • Place of Presentation
      札幌
    • Year and Date
      2016-03-22
    • Related Report
      2015 Annual Research Report
  • [Presentation] 重力変化に対する前庭系の可塑性2015

    • Author(s)
      森田啓之
    • Organizer
      第74回めまい平衡学会総会
    • Place of Presentation
      岐阜
    • Year and Date
      2015-11-25
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Vestibular system is involved in changes of muscle and bone induced by hypergravity in mice.2015

    • Author(s)
      Kawao N, Morita H, Obata K, Tamura Y, Okumoto K, Kaji H
    • Organizer
      37th Annual Meeting of American Society for Bone and Mineral Research
    • Place of Presentation
      Seattle Washington, USA
    • Year and Date
      2015-10-09
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] きぼうマウス実験:短腕遠心機内でのマウス飼育2015

    • Author(s)
      森田啓之,芝大,白川正輝,工藤崇,高橋智
    • Organizer
      第29回宇宙生物学会大会
    • Place of Presentation
      東京
    • Year and Date
      2015-09-26
    • Related Report
      2015 Annual Research Report
  • [Remarks]

    • URL

      http://living-in-space.jp/

    • Related Report
      2018 Annual Research Report
  • [Remarks] 宇宙に生きる:宇宙からひも解く新たな生命制御機構の統合的理解

    • URL

      http://living-in-space.jp/

    • Related Report
      2017 Annual Research Report
  • [Remarks] A02-2 前庭系可塑性応答の統合的理解と適応障害対策

    • URL

      http://living-in-space.jp/planning-study/A02-2/

    • Related Report
      2015 Annual Research Report

URL: 

Published: 2015-07-02   Modified: 2022-11-04  

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