| Budget Amount *help |
¥95,030,000 (Direct Cost: ¥73,100,000、Indirect Cost: ¥21,930,000)
Fiscal Year 2019: ¥16,640,000 (Direct Cost: ¥12,800,000、Indirect Cost: ¥3,840,000)
Fiscal Year 2018: ¥16,640,000 (Direct Cost: ¥12,800,000、Indirect Cost: ¥3,840,000)
Fiscal Year 2017: ¥16,640,000 (Direct Cost: ¥12,800,000、Indirect Cost: ¥3,840,000)
Fiscal Year 2016: ¥16,640,000 (Direct Cost: ¥12,800,000、Indirect Cost: ¥3,840,000)
Fiscal Year 2015: ¥28,470,000 (Direct Cost: ¥21,900,000、Indirect Cost: ¥6,570,000)
|
|---|
| Outline of Final Research Achievements |
We developed the system of simultaneous irradiation (ultraviolet-light, X-rays, C-ions, and neutron) in simulated-microgravity and partial gravity using a clinostat. Using these simulator, we reported reduced expression of cell-cycle-suppressing genes and enhanced expression of cell-cycle promoting ones in human fibroblast cells after C ion irradiation under simulated-microgravity. Supporting this result, we have also reported a higher rate of chromosomal aberrations and abnormalities in the same combined conditions. Furthermore, we clarified that autophagy is important for overcoming ultraviolet-light and microgravity obstacles. We also reported that hindlimb suspension significantly increased tumor growth and metastasis to the lung, and caused greater thymic and splenocyte atrophy compared with mice in constant orthostatic suspension or unmanipulated mice under standard housing conditions.
|
