| Budget Amount *help |
¥157,950,000 (Direct Cost: ¥121,500,000、Indirect Cost: ¥36,450,000)
Fiscal Year 2019: ¥29,640,000 (Direct Cost: ¥22,800,000、Indirect Cost: ¥6,840,000)
Fiscal Year 2018: ¥29,770,000 (Direct Cost: ¥22,900,000、Indirect Cost: ¥6,870,000)
Fiscal Year 2017: ¥29,770,000 (Direct Cost: ¥22,900,000、Indirect Cost: ¥6,870,000)
Fiscal Year 2016: ¥29,640,000 (Direct Cost: ¥22,800,000、Indirect Cost: ¥6,840,000)
Fiscal Year 2015: ¥39,130,000 (Direct Cost: ¥30,100,000、Indirect Cost: ¥9,030,000)
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| Outline of Final Research Achievements |
We established a novel in-vitro system for studying mitotic chromosome assembly, in which mouse sperm nuclei were incubated with frog egg extracts. By taking full advantage of this unique system, it was discovered that mitotic chromosome-like structures can be constructed, in a manner dependent of condensins I and II, even under the condition where nucleosome assembly in completely blocked. Moreover, we uncovered a molecular mechanism that helps delay pronuclei formation in mouse eggs after fertilization.
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