| Budget Amount *help |
¥124,540,000 (Direct Cost: ¥95,800,000、Indirect Cost: ¥28,740,000)
Fiscal Year 2019: ¥23,140,000 (Direct Cost: ¥17,800,000、Indirect Cost: ¥5,340,000)
Fiscal Year 2018: ¥23,270,000 (Direct Cost: ¥17,900,000、Indirect Cost: ¥5,370,000)
Fiscal Year 2017: ¥23,270,000 (Direct Cost: ¥17,900,000、Indirect Cost: ¥5,370,000)
Fiscal Year 2016: ¥23,140,000 (Direct Cost: ¥17,800,000、Indirect Cost: ¥5,340,000)
Fiscal Year 2015: ¥31,720,000 (Direct Cost: ¥24,400,000、Indirect Cost: ¥7,320,000)
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| Outline of Final Research Achievements |
Sister chromatid cohesion (SCC) is essential for proper chromosome segregation in mitosis and meiosis. During meiosis, a meiosis-specific cohesin promotes not only the segregation of chromosomes at both meiosis I and II but also chromosome dynamics in prophase I. In budding yeast meiosis, it is known that the removal of cohesin from chromosome arms by the cleavage of Rec8, a meiosis-specific α-kleisin subunit, triggers the segregation of homologous chromosomes during meiosis I. We found that large amounts of Rec8, thus meiosis-specific cohesion, is removed from chromosomes, particularly from chromosome arms in the late prophase I of the yeast. This removal of Rec8 is cleavage-independent. This meiosis-specific prophase pathway requires the phosphorylation of cohesin components, Rec8 and Rad61/Wpl1(Wapl) by PLK and DDK kinases. We will discuss the biological significance for the removal of cohesin from chromosome arms in late prophase I.
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