| Budget Amount *help |
¥180,960,000 (Direct Cost: ¥139,200,000、Indirect Cost: ¥41,760,000)
Fiscal Year 2019: ¥37,960,000 (Direct Cost: ¥29,200,000、Indirect Cost: ¥8,760,000)
Fiscal Year 2018: ¥33,410,000 (Direct Cost: ¥25,700,000、Indirect Cost: ¥7,710,000)
Fiscal Year 2017: ¥38,090,000 (Direct Cost: ¥29,300,000、Indirect Cost: ¥8,790,000)
Fiscal Year 2016: ¥33,410,000 (Direct Cost: ¥25,700,000、Indirect Cost: ¥7,710,000)
Fiscal Year 2015: ¥38,090,000 (Direct Cost: ¥29,300,000、Indirect Cost: ¥8,790,000)
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| Outline of Final Research Achievements |
This study aims to clarify the linkage between chromosome 3D and 4D structures and chromosome functions by utilizing genomics, genetics and biochemical techniques. As studying materials, I focused on the process of cell differentiation and rare disease. Notable achievements include: 1) the elucidation of precise mechanisms of cohesin acetylation by two different pathways; 2) the clarification of role of cohesin in cerebral cortical differentiation; 3) biochemical identification of cohesin in the transcriptional machinery; and 4) biochemical clarification of the role of cohesin in transcription. In addition, I introduced genome-wide chromosome structure analysis technologies such as Hi-C, Pore-C, quantitative ChIP-seq, and ChIA-drop, and provided them to the researchers worldwide.
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