| Budget Amount *help |
¥157,950,000 (Direct Cost: ¥121,500,000、Indirect Cost: ¥36,450,000)
Fiscal Year 2019: ¥29,640,000 (Direct Cost: ¥22,800,000、Indirect Cost: ¥6,840,000)
Fiscal Year 2018: ¥29,770,000 (Direct Cost: ¥22,900,000、Indirect Cost: ¥6,870,000)
Fiscal Year 2017: ¥29,770,000 (Direct Cost: ¥22,900,000、Indirect Cost: ¥6,870,000)
Fiscal Year 2016: ¥29,640,000 (Direct Cost: ¥22,800,000、Indirect Cost: ¥6,840,000)
Fiscal Year 2015: ¥39,130,000 (Direct Cost: ¥30,100,000、Indirect Cost: ¥9,030,000)
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| Outline of Final Research Achievements |
Aneuploidy is a widespread feature of malignancies which is caused by persistent chromosome segregation defects in mitosis through a mechanism called chromosomal instability, or CIN. The goal of this study is to elucidate the alterations of chromosome orchestration system overtime underlying CIN. In cells recapitulating malignant transformation, we found that the structure of centromeres and the coordination of mitotic progression with chromosome dynamics on chromosomal platform are impaired, and thus cells continually undergo chromosome missegregation. Remarkably we found that cancer stem cells reveal high levels of CIN, implying its pathological relevance that these cells evolved resistance to chromosomal stress caused by aneuploidy.
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