| Budget Amount *help |
¥95,290,000 (Direct Cost: ¥73,300,000、Indirect Cost: ¥21,990,000)
Fiscal Year 2019: ¥18,460,000 (Direct Cost: ¥14,200,000、Indirect Cost: ¥4,260,000)
Fiscal Year 2018: ¥18,590,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥4,290,000)
Fiscal Year 2017: ¥18,590,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥4,290,000)
Fiscal Year 2016: ¥18,590,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥4,290,000)
Fiscal Year 2015: ¥21,060,000 (Direct Cost: ¥16,200,000、Indirect Cost: ¥4,860,000)
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| Outline of Final Research Achievements |
The construction of a 4C, Hi-C and other higher order structure analysis pipeline including the original analysis method was realized. Also, the development of a novel high-precision genome assembly method and the construction of various NGS analysis pipelines such as ChIP-seq analysis was performed. By using these, we have realized various chromosomal structure analyzes from yeast to human and mouse, and succeeded in achieving joint research results with many members. In the analysis of myelodysplastic syndrome, analysis of mouse experimental data led to the discovery of a mechanism of abnormal gene expression regulation. On the other hand, the developed pipeline and various analyzed data are stored together with various public data on the newly constructed chromosome OS platform. By uploading the users own NGS data through WWW service, the user can perform various analysis in the platform, and the result can be browsed and compared with the public data on this platform.
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