| Co-Investigator(Kenkyū-buntansha) |
浅川 明弘 鹿児島大学, 医歯学域医学系, 教授 (10452947)
須藤 信行 九州大学, 医学研究院, 教授 (60304812)
佐久間 英輔 名古屋市立大学, 医薬学総合研究院(医学), 講師 (90295585)
井上 浩一 名古屋市立大学, 大学院医学研究科, 准教授 (80345818)
|
|---|
| Budget Amount *help |
¥164,190,000 (Direct Cost: ¥126,300,000、Indirect Cost: ¥37,890,000)
Fiscal Year 2020: ¥34,580,000 (Direct Cost: ¥26,600,000、Indirect Cost: ¥7,980,000)
Fiscal Year 2019: ¥34,580,000 (Direct Cost: ¥26,600,000、Indirect Cost: ¥7,980,000)
Fiscal Year 2018: ¥34,580,000 (Direct Cost: ¥26,600,000、Indirect Cost: ¥7,980,000)
Fiscal Year 2017: ¥34,580,000 (Direct Cost: ¥26,600,000、Indirect Cost: ¥7,980,000)
Fiscal Year 2016: ¥25,870,000 (Direct Cost: ¥19,900,000、Indirect Cost: ¥5,970,000)
|
|---|
| Outline of Final Research Achievements |
In order to elucidate the mechanisms of the disturbed social-brain-body interactions that hinder psychological development and motivation, we focused on the elucidation of molecular and neural bases of the brain-gut interactions controlled by the digestive system. In an anorexia model mouse, artificial flora mice transplanted with the patient's intestinal flora had poor weight gain and were vulnerable to stress, mice with reduced amino acid levels in the blood became overactive, and some gastrointestinal peptides suppressed the brain inflammatory responses with toxic transformation of microglia and amplified adult cranial neurogenesis, It was also found that the fractalkine-CX3CR1 signaling, the green leaf protein-derived peptides, and the vacuolating cytotoxin A produced by helicobacter pylori were involved in emotion. Behavioral model systems for zebrafish were also established.
|
